Search

Your search keyword '"Brenda Heron"' showing total 1 results
Start Over Author "Brenda Heron"
1 results on '"Brenda Heron"'

1. A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

Author

Monica Florio, Kannan Gunasekaran, Marina Stolina, Xiaodong Li, Ling Liu, Barbara Tipton, Hossein Salimi-Moosavi, Franklin J. Asuncion, Chaoyang Li, Banghua Sun, Hong Lin Tan, Li Zhang, Chun-Ya Han, Ryan Case, Amy N. Duguay, Mario Grisanti, Jennitte Stevens, James K. Pretorius, Efrain Pacheco, Heidi Jones, Qing Chen, Brian D. Soriano, Jie Wen, Brenda Heron, Frederick W. Jacobsen, Emil Brisan, William G. Richards, Hua Zhu Ke, and Michael S. Ominsky

Subjects
Science
Abstract

Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture repair in rodents and bone formation in primates.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results