120 results on '"Brereton RJ"'
Search Results
2. Intussusception and Duodenal Stenosis: An Infrequent But Expected Association
- Author
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Brereton Rj and Ward Hc
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,Duodenal stenosis ,Gastroenterology ,Postoperative Complications ,Internal medicine ,Intussusception (medical disorder) ,Duodenostomy ,medicine ,Humans ,Ileal Diseases ,business.industry ,Infant ,Invagination ,medicine.disease ,Surgery ,Stenosis ,medicine.anatomical_structure ,El Niño ,Intestinal malrotation ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Duodenum ,Duodenal Obstruction ,business ,Intussusception - Abstract
Two boys with intussusception, intestinal malrotation and duodenal stenosis are reported. Because intussusception is associated with malrotation, which is in turn associated with duodenal stenosis, this combination of abnormalities may be expected in up to 3% of children with intussusception.
- Published
- 1992
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3. Peno-Scrotal Transposition and the Caudal Regression Syndrome
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Turnock Rr and Brereton Rj
- Subjects
Male ,endocrine system ,medicine.medical_specialty ,Variable severity ,endocrine system diseases ,Anal Canal ,urologic and male genital diseases ,Scrotal transposition ,Thoracic hemivertebrae ,Transposition (music) ,Scrotum ,medicine ,Humans ,Abnormalities, Multiple ,Vesico-Ureteral Reflux ,Caudal regression syndrome ,urogenital system ,business.industry ,Infant, Newborn ,Rectum ,Reflux ,Syndrome ,Anatomy ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,business ,Penis - Abstract
Peno-scrotal transposition is a rare condition of variable severity, often associated with the Caudal Regression Syndrome. A case of incomplete peno-scrotal transposition, with a perineal anorectal duplication, vesico-ureteric reflux and thoracic hemivertebrae is presented. The literature is reviewed.
- Published
- 1991
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4. [Untitled]
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Brereton Rj
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medicine.medical_specialty ,Midgut malrotation ,business.industry ,Internal medicine ,Concomitant ,Pediatrics, Perinatology and Child Health ,medicine ,Surgery ,General Medicine ,business ,Gastroenterology ,Hypertrophic Pyloric Stenosis ,Short bowel - Published
- 1992
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5. [Untitled]
- Author
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Brereton Rj
- Subjects
medicine.medical_specialty ,business.industry ,Pain relief ,General Medicine ,Psychology child ,Pain management ,Infant newborn ,Surgery ,Pediatrics, Perinatology and Child Health ,Physical therapy ,medicine ,Descriptive research ,business - Published
- 1991
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6. Necrotising Enterocolitis in Small Bowel Atresia
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Brereton Rj, Wright Vm, and Lafferty K
- Subjects
medicine.medical_specialty ,business.industry ,Significant difference ,Intestinal atresia ,Infant, Newborn ,Intestinal Atresia ,Infant ,Peritonitis ,Retrospective cohort study ,medicine.disease ,Surgery ,Necrotising enterocolitis ,England ,Atresia ,Intestine, Small ,Pediatrics, Perinatology and Child Health ,medicine ,Overall survival ,Humans ,business ,Enterocolitis, Pseudomembranous ,Retrospective Studies ,Neonatal necrotising enterocolitis - Abstract
A retrospective study of 76 infants with small bowel atresia treated in two neonatal surgical units between 1970 and 1979 is presented. The overall survival rate was 75% and there was no significant difference between the two centres. The mortality rose according to the number of atresias and the distance of the first atresia from the ileo-caecal valve. The 19 deaths were classified as inevitable or avoidable. Of the latter group, 5 out of 14 deaths were due to neonatal necrotising enterocolitis, and the remainder to respiratory problems associated with prematurity or to surgical complications producing peritonitis and septicaemia.
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- 1983
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7. Simple Old Surgery for Juvenile Embedded Toenails
- Author
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Brereton Rj
- Subjects
Wound Healing ,medicine.medical_specialty ,integumentary system ,business.industry ,Nails, Ingrown ,Granulation tissue ,Nail fold ,Surgery ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Wound Infection ,medicine ,Humans ,Juvenile ,Child ,business ,Follow-Up Studies - Abstract
During a period of 3 1/2 years, 42 consecutive children with severely infected embedded toenails were treated by excision of the nail fold and granulation tissue. Of the 49 toes so treated, 43 (88%) were cured within an average time of 5 weeks. The cosmetic results were excellent, and there have been no recurrences during the period of review (mean of 82 weeks).
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- 1980
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8. Percutaneous coronary intervention versus coronary-artery bypass grafting.
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Brereton RJ, Misfeld M, and Ross DE
- Published
- 2009
9. Post-Dissection Single-Stage Arch and Descending Aorta Replacement via Clamshell Incision.
- Author
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Cullen P, Brereton RJ, and Mathur MN
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- Aorta, Thoracic diagnostic imaging, Aorta, Thoracic surgery, Dissection, Humans, Thoracotomy, Aortic Dissection surgery, Blood Vessel Prosthesis Implantation
- Abstract
Residual dissections after type A repairs are common and can result in aneurysm formation. Surgery is complex and considered high risk, particularly if there is arch involvement. A single-stage "arch-first" technique via clamshell incision is an excellent option in certain circumstances and herein we detail a variation of this approach using a trifurcated graft., (Copyright © 2021. Published by Elsevier B.V.)
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- 2021
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10. Long Term Outcomes Following Freestyle Stentless Aortic Bioprosthesis Implantation: An Australian Experience.
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Sherrah AG, Jeremy RW, Puranik R, Bannon PG, Hendel PN, Bayfield MS, Wilson MK, Brady PW, Marshman D, Mathur MN, Brereton RJ, Edwards JR, Stuklis RG, Worthington M, and Vallely MP
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- Aged, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate, Ultrasonography, Aortic Diseases diagnostic imaging, Aortic Diseases mortality, Aortic Diseases surgery, Bioprosthesis, Blood Vessel Prosthesis
- Abstract
Background: The Freestyle stentless bioprosthesis (FSB) has been demonstrated to be a durable prosthesis in the aortic position. We present data following Freestyle implantation for up to 10 years post-operatively and compare this with previously published results., Methods: A retrospective cohort analysis of 237 patients following FSB implantation occurred at five Australian hospitals. Follow-up data included clinical and echocardiographic outcomes., Results: The cohort was 81.4% male with age 63.2±13.0 years and was followed for a mean of 2.4±2.3 years (range 0-10.9 years, total 569 patient-years). The FSB was implanted as a full aortic root replacement in 87.8% patients. The 30-day all cause mortality was 4.2% (2.0% for elective surgery). Cumulative survival at one, five and 10 years was 91.7±1.9%, 82.8±3.8% and 56.5±10.5%, respectively. Freedom from re-intervention at one, five and 10 years was 99.5±0.5%, 91.6±3.7% and 72.3±10.5%, respectively. At latest echocardiographic review (mean 2.3±2.1 years post-operatively), 92.6% had trivial or no aortic regurgitation. Predictors of post-operative mortality included active endocarditis, acute aortic dissection and peripheral vascular disease., Conclusions: We report acceptable short and long term outcomes following FSB implantation in a cohort of comparatively younger patients with thoracic aortic disease. The durability of this bioprosthesis in the younger population remains to be confirmed., (Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2016
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11. Intraoperative coronary angiography: a novel method.
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Brereton RJ, Fong LS, and Fabrin A
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- Aged, Humans, Male, Coronary Angiography, Coronary Artery Bypass, Off-Pump, Intraoperative Care methods
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- 2014
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12. Surgical aortic valve replacement in very elderly patients aged 80 years and over: evaluation of early clinical outcomes.
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Ho E, Mathur MN, Brady PW, Marshman D, Brereton RJ, Ross DE, Bhindi R, and Hansen PS
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- Aged, 80 and over, Aortic Valve Stenosis mortality, Female, Follow-Up Studies, Heart Valve Prosthesis Implantation adverse effects, Humans, Male, Renal Insufficiency etiology, Renal Insufficiency mortality, Retrospective Studies, Risk Factors, Stroke etiology, Stroke mortality, Time Factors, Aortic Valve Stenosis surgery, Health Services for the Aged, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation methods
- Abstract
Background: An increasing number of very elderly patients aged ≥80 years will require aortic valve replacement (AVR) for severe aortic stenosis (AS). Many are classified as high-risk surgical candidates. Transcatheter aortic valve implantation (TAVI) has been proposed as an alternative to surgical AVR (SAVR) for high-risk patients. We evaluated early clinical outcomes of very elderly patients undergoing SAVR to optimise TAVI candidate selection., Methods: We conducted a retrospective case review of 132 consecutive patients aged ≥80 years undergoing isolated SAVR (49 patients) or combined SAVR/CABG (83 patients) during February 2002-January 2010 at a single tertiary referral hospital. Risk for cardiac surgery was calculated using the logistic EuroSCORE (ES(log)). Mortality and morbidity data were collected for the 30-day postoperative period., Results: Thirty-day mortality rate was 8.3% for patients undergoing SAVR (6.1% for isolated SAVR and 9.6% for SAVR/CABG). Permanent stroke occurred in 3.8% and renal insufficiency in 7.6% of the cohort. Thirty-five percent of patients had left ventricular ejection fraction <50%, 67% had advanced symptoms (NYHA class III or IV), and 42% of patients were stratified as high-risk (ES(log)≥20%)., Conclusions: SAVR can be performed in very elderly patients with acceptable operative morbidity and mortality. The outcomes at our institution are comparable to contemporary SAVR and TAVI outcomes., (Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.)
- Published
- 2014
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13. Anaortic off-pump coronary artery bypass grafting in the elderly and very elderly.
- Author
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Cooper EA, Edelman JJ, Black D, Brereton RJ, Ross DE, Bannon PG, Wilson MK, and Vallely MP
- Subjects
- Aged, Aged, 80 and over, Disease-Free Survival, Female, Humans, Male, Perioperative Period, Prospective Studies, Stroke etiology, Stroke mortality, Survival Rate, Coronary Artery Bypass, Off-Pump, Health Services for the Aged
- Abstract
Background: Elderly patients undergoing surgical revascularisation may disproportionately benefit from avoiding manipulation of the ascending aorta and cardiopulmonary bypass. In this multi-centre observational study, we sought to determine the 30-day outcomes of anaortic off-pump coronary artery bypass (OPCAB) in an elderly and very-elderly population., Methods: Data were prospectively collected for all patients aged >70 years old (y) undergoing anaortic OPCAB at three hospitals between January 2002 and October 2011. Analysis was carried out on two age sub-groups (70-79 y vs. ≥80 y). Multiple logistic regression was used to identify predictors of post-operative 30-day mortality., Results: In total, 1135 patients >70 years underwent anaortic OPCAB - 817 (72%) patients were aged 70-79 y while 318 (28%) were aged ≥80 y. The rate of mortality and morbidity for both groups was low: 30-day mortality (70-79 y: 1.8%; ≥80 y: 2.8%) or permanent stroke (70-79 y: 0.2%; ≥80 y: 0.9%). Chronic lung disease, a history of previous myocardial infarction and left main disease were independent predictors of 30-day mortality., Conclusions: OPCAB is associated with low rates of 30-day mortality and peri-operative stroke in this elderly and very elderly patient cohort. Anaortic OPCAB can provide excellent short-term post-operative outcomes and may give the elderly and very elderly population the opportunity to benefit from surgical coronary revascularisation., (Copyright © 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2013
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14. Anaortic, total-arterial, off-pump coronary artery bypass surgery: why bother?
- Author
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Edelman JJ, Sherrah AG, Wilson MK, Bannon PG, Brereton RJ, Ross DE, and Vallely MP
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- Aorta surgery, Humans, Mammary Arteries transplantation, Radial Artery transplantation, Vascular Patency, Coronary Artery Bypass, Off-Pump adverse effects, Coronary Artery Bypass, Off-Pump methods, Stroke etiology
- Abstract
Coronary artery bypass grafting (CABG) remains the standard of care for multi-vessel coronary disease. However, the increased rate of peri-operative stroke reported after surgery compared to percutaneous coronary intervention (PCI) remains of concern. Anaortic, total-arterial, off-pump coronary artery bypass (OPCAB) grafting is a technique that offers the main advantages of surgical revascularisation with a rate of stroke that is equivalent to that of PCI. Some recent trials comparing conventional on-pump CABG with OPCAB have questioned the efficacy of the off-pump technique - these are most often performed with manipulation of the ascending aorta. We review the potential benefits of the anaortic, total-arterial OPCAB technique to explain why it is being employed by an increasing number of surgeons., (Copyright © 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2013
- Full Text
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15. Neurologic complications after off-pump coronary artery bypass grafting with and without aortic manipulation: meta-analysis of 11,398 cases from 8 studies.
- Author
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Misfeld M, Brereton RJ, Sweetman EA, and Doig GS
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- Humans, Ischemic Attack, Transient prevention & control, Postoperative Complications prevention & control, Stroke prevention & control, Aorta surgery, Coronary Artery Bypass, Off-Pump methods, Ischemic Attack, Transient etiology, Stroke etiology
- Abstract
Objective: Neurologic complications after coronary artery bypass grafting remain a concern. Off-pump coronary artery bypass grafting is a surgical strategy proposed to decrease this risk. Use of an off-pump anaortic technique, which leaves the ascending aorta untouched, may result in further reductions. This systematic review of all published evidence compares neurologic complications after anaortic off-pump coronary artery bypass grafting versus that with aortic manipulation., Methods: PubMed and Embase were searched up to August 2008. Experts were contacted, and reference lists of retrieved articles were hand searched. The search process was not limited to English-language sources. Observational studies comparing standard off-pump coronary artery bypass grafting technique with anaortic technique were eligible for inclusion if they reported neurologic complications (stroke and transient ischemic attack). Meta-analysis was conducted to assess differences between groups with regard to neurologic complications., Results: Electronic search identified 1428 abstracts, which resulted in retrieval and detailed review of 331 full-text articles. Eight observational studies reported neurologic complications in 5619 anaortic off-pump coronary artery bypass grafting cases and 5779 cases with aortic manipulation. Postsurgical neurologic complications were significantly lower in anaortic off-pump coronary artery bypass grafting cases (odds ratio, 0.46; 95% confidence interval, 0.29-0.72; I(2) = 0.8%; P = .0008)., Conclusions: Avoidance of aortic manipulation during off-pump coronary artery bypass grafting decreases neurologic complications relative to standard technique in which the ascending aorta is manipulated. In patients at high risk for stroke or transient ischemic attack, we recommend avoidance of aortic manipulation during off-pump coronary artery bypass grafting., (Copyright © 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.)
- Published
- 2011
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16. Anaortic, total-arterial, off-pump coronary artery bypass surgery: how to do it.
- Author
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Vallely MP, Yan TD, Edelman JJ, Hayman M, Brereton RJ, and Ross DE
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- Anastomosis, Surgical methods, Anesthesia methods, Humans, Perioperative Period, Coronary Artery Bypass, Off-Pump methods, Mammary Arteries transplantation, Postoperative Complications prevention & control, Radial Artery transplantation, Stroke prevention & control
- Abstract
Several large series have demonstrated that performing off-pump coronary artery bypass surgery without manipulating the ascending aorta (anaortic) utilising all-arterial grafts provides superior protection against neurological injury. Recent series comparing percutaneous coronary intervention (PCI) with surgical revascularisation have demonstrated superior results for surgery over PCI. However, a significant criticism of coronary artery surgery remains the higher incidence of neurological injury when compared to PCI. We present a simple and reproducible technique for anaortic, total-arterial off-pump coronary artery revascularisation., (Copyright (c) 2010 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All rights reserved.)
- Published
- 2010
- Full Text
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17. Anaortic techniques reduce neurological morbidity after off-pump coronary artery bypass surgery.
- Author
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Vallely MP, Potger K, McMillan D, Hemli JM, Brady PW, Brereton RJ, Marshman D, Mathur MN, and Ross DE
- Subjects
- Adult, Aged, Aged, 80 and over, Aorta surgery, Case-Control Studies, Coronary Artery Bypass, Off-Pump adverse effects, Female, Humans, Male, Middle Aged, Odds Ratio, Retrospective Studies, Stroke etiology, Survival Analysis, Coronary Artery Bypass, Off-Pump methods, Stroke prevention & control
- Abstract
Background: Stroke remains one of the most devastating complications of cardiac surgery. Advocates of off-pump coronary revascularisation (OPCAB) maintain that post-operative neurologic morbidity is reduced by avoiding aortic cannulation and cross-clamping, and by eliminating the systemic effects of cardiopulmonary bypass. We sought to determine whether completing off-pump coronary surgery without any aortic manipulation ("anaortic" technique) afforded any additional neurological protection, as compared to off-pump grafting in which the aorta was utilised for graft inflow., Methods: A comprehensive review of prospectively collected data was undertaken of all patients undergoing OPCAB in our institution between January 2002 and December 2006. Cases requiring intra-operative conversion to cardiopulmonary bypass were excluded from further analysis. Patients having OPCAB surgery with aortic manipulation were compared to those having OPCAB surgery without aortic manipulation. Multiple logistic regression was used to identify possible predictors of post-operative neurologic morbidity, with particular focus on the role of aortic manipulation., Results: During the period of review, 1758 patients underwent OPCAB, of which 1201 (68.3%) were completed without aortic manipulation, constituting the "anaortic" cohort. This group was compared with the remaining 557 patients, which included fashioning at least one aorto-conduit anastomosis, utilising either a side-biting aortic clamp or a no-clamp proximal anastomotic device. The two groups of patients were well-matched with respect to risk factors for adverse neurologic outcomes. Nine patients sustained focal neurological deficits (transient or permanent) in the peri-operative period, constituting a stroke rate of 0.51% for the entire series. The incidence of peri-operative neurological deficit in the anaortic group was 0.25% compared with 1.1% in the aortic manipulation group (odds ratio (OR) 0.23, 95% confidence interval (CI) 0.06-0.92, p=0.037). Advanced age was also associated with peri-operative neurological injury (OR 1.1, 95% CI 1.01-1.20, p=0.017)., Conclusions: Off-pump coronary artery surgery is associated with a low incidence of peri-operative stroke. Completing the surgical procedure without manipulating the ascending aorta in any way ("anaortic" technique) offers additional neurological protection and should be the goal in all suitable off-pump coronary cases.
- Published
- 2008
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18. Simple incision: a safe and definitive procedure for congenital duodenal diaphragm.
- Author
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Zia-ul-Miraj M, Madden NP, and Brereton RJ
- Subjects
- Child, Preschool, Digestive System Surgical Procedures methods, Humans, Infant, Infant, Newborn, Intestinal Obstruction etiology, Intestinal Perforation etiology, Retrospective Studies, Duodenum abnormalities, Intestinal Obstruction surgery, Intestinal Perforation surgery
- Abstract
Background: Duodenal diaphragms generally are treated by either a duodeno-duodenostomy or excision. The former is a bypass procedure that involves a major anastomosis with its inherent postoperative problems, whereas the latter may result in inadvertent damage to the biliary and pancreatic ducts. To circumvent these problems, the authors used the technique of incision of the diaphragm on its lateral aspect., Methods: Medical records of five children who underwent surgery for a perforate duodenal diaphragm during the period of 1992 through 1994 were reviewed retrospectively. All patients underwent a similar procedure. A longitudinal duodenotomy was made and the diaphragm incised on its anterolateral aspect. The cut edges of the diaphragm were oversewn, and the duodenotomy closed in "Heineke-Mikulicz" fashion., Results: At a follow-up ranging from 1 to 3 years, all patients are growing normally and remain free of any obstructive symptoms., Conclusions: This simplified approach is a safe and physiological way of restoring the duodenal continuity and is associated with a highly satisfactory outcome.
- Published
- 1999
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19. Currarino's triad: an unusual cause of constipation in children.
- Author
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Zia-ul-Miraj M and Brereton RJ
- Subjects
- Anal Canal abnormalities, Colostomy, Constipation diagnostic imaging, Constipation surgery, Constriction, Pathologic complications, Constriction, Pathologic congenital, Constriction, Pathologic diagnostic imaging, Female, Follow-Up Studies, Humans, Infant, Newborn, Meningocele diagnostic imaging, Sacrum diagnostic imaging, Tomography, X-Ray Computed, Abnormalities, Multiple, Constipation etiology, Meningocele complications, Rectum abnormalities, Sacrum abnormalities
- Abstract
A 6-year-old girl presented with intractable constipation. On investigation, she was found to have an association of anorectal stenosis, anterior sacral defect, and anterior meningocoele (Currarino's triad). The meningocoele was excised and a Duhamel pull-through procedure performed after resection of a massively distended rectosigmoid. Post-operatively, she started having spontaneous bowel action. Early diagnosis and management is recommended to avoid the high mortality and morbidity associated with this condition.
- Published
- 1998
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20. Rectal ectasia associated with anorectal anomalies.
- Author
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Zia-ul-Miraj M and Brereton RJ
- Subjects
- Anal Canal surgery, Congenital Abnormalities surgery, Constipation etiology, Dilatation, Pathologic, Humans, Infant, Newborn, Male, Rectum pathology, Rectum surgery, Anal Canal abnormalities, Rectum abnormalities
- Abstract
Rectal ectasia may be associated with anorectal anomalies. If not recognized at the time of surgical reconstruction it may lead to megarectosigmoid, resulting in severe constipation and overflow incontinence postoperatively. The authors treated four patients presenting with this condition. One patient born with a low anorectal anomaly and two with high anorectal anomalies experienced intractable constipation caused by megarectum despite otherwise adequate primary reconstructive procedures. A fourth patient had rectal stenosis in association with megarectosigmoid. The ectatic megarectum had to be resected in all the patients to achieve normal bowel actions. The authors feel that resection or tailoring of the ectatic segment should be an integral part of the primary reconstructive procedure.
- Published
- 1997
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21. Acute scrotum: an unusual presentation of Henoch-Schönlein purpura in children.
- Author
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Zia-ul-Miraj M and Brereton RJ
- Subjects
- Child, Genital Diseases, Male diagnosis, Humans, Male, IgA Vasculitis diagnosis, Scrotum
- Published
- 1996
22. Neural cell adhesion molecule (NCAM) expression in nerves and muscle of developing human large bowel.
- Author
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Romanska HM, Bishop AE, Moscoso G, Walsh FS, Spitz L, Brereton RJ, and Polak JM
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- Actins analysis, Aging, Desmin analysis, Female, Gestational Age, Humans, Immunohistochemistry, Infant, Intestinal Mucosa chemistry, Intestine, Large embryology, Intestine, Large growth & development, Male, Muscle Development, Muscle, Smooth growth & development, Nerve Fibers chemistry, Neurons chemistry, Pregnancy, Tissue Distribution, Intestine, Large chemistry, Muscle, Smooth chemistry, Muscle, Smooth innervation, Neural Cell Adhesion Molecules analysis
- Abstract
Most studies of neural cell adhesion molecule (NCAM) in human musculature are devoted to either developing or adult skeletal and cardiac muscle. The aim of this study was to determine the pattern of NCAM expression in the intestinal musculature of the developing human large bowel. In specimens of large bowel from foetuses (gestational age 8-20 weeks), we examined the immunohistochemical localisation of NCAM in parallel to those of alpha-smooth muscle actin and desmin. Within the developing neural complex, NCAM was expressed at all stages investigated. In intestinal muscle at 8 weeks, immunoreactivity for all antisera was restricted to the muscularis propria. The differentiating muscularis mucosae was demonstrated first at 15 weeks by immunostaining for alpha-smooth muscle actin, and this expression was followed by that of NCAM and desmin at 17 and 19 weeks, respectively. At 20 weeks, NCAM immunoreactivity in the external muscle was intense at the inner border of the circular muscle, with its concentration decreasing towards the outer margin of the muscular wall, whereas alpha-smooth muscle actin and desmin were uniformly distributed in all muscle layers. NCAM is expressed by nerves and muscle of developing human large intestine. Its appearance follows a predetermined pattern, which implies its relevance to the differentiation of intestinal muscle layers.
- Published
- 1996
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23. Oronasopharyngeal teratomas.
- Author
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Zia-Ul-Miraj Ahmad M, Brereton RJ, and Madden NP
- Abstract
Oronasopharyngeal teratomas are rare tumours that usually present in the neonatal period with airway obstruction. Management should include prompt establishment of the airway and early excision. Complete excision is recommended, which may require more than one operation, but multilating surgery should be avoided as the malignant potential of these tumours is extremely low. We describe our experience with three patients along with a literature review.
- Published
- 1996
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24. Rectal atresia and stenosis.
- Author
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Zia-w-Miraj Ahmad M, Brereton RJ, and Huskisson L
- Subjects
- Colectomy methods, Colostomy adverse effects, Dilatation adverse effects, Embryonic and Fetal Development, Female, Humans, Infant, Infant, Newborn, Intestinal Obstruction complications, Intestinal Obstruction diagnosis, Intestinal Obstruction surgery, Male, Rectal Diseases complications, Rectal Diseases diagnosis, Rectal Diseases surgery, Rectum embryology, Intestinal Obstruction congenital, Rectal Diseases congenital, Rectum abnormalities
- Abstract
Rectal atresia and stenosis are rare and peculiar anorectal malformations for which many and varied surgical procedures have been described, ranging from simple perforation of the atresia to extensive sacro-abdomino-perineal pull-through operations. The results of the operations have been generally unsatisfactory, chronic constipation being a common postoperative feature. In the authors' experience, the Duhamel pull-through is the operation of choice for this problem.
- Published
- 1995
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25. Scattered radiation in a neonatal surgical unit.
- Author
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Iyer KR, Spitz L, Kiely E, Drake DP, Dykes E, Evans K, Wallace M, and Brereton RJ
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- Humans, Infant, Newborn, Radiometry, Scattering, Radiation, Intensive Care Units, Neonatal, Radiography adverse effects
- Abstract
We studied the doses of "scattered" received by neonates in a Neonatal Surgical Unit by placing thermoluminescent dosemeters in various positions expect the direct beam. Doses of "scattered" radiation received by neonates as a results of exposure of their neighbours to X-ray examinations were found to be negligible. Sick neonates need not be moved from their neighbours undergoing exposure to X-rays.
- Published
- 1995
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26. Colonic stricture in a boy with cystic fibrosis.
- Author
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Ong PS, Oades PJ, Bush A, and Brereton RJ
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- Child, Preschool, Colonic Diseases pathology, Cystic Fibrosis pathology, Humans, Intestinal Obstruction pathology, Intestines pathology, Male, Microspheres, Colonic Diseases etiology, Cystic Fibrosis complications, Intestinal Obstruction etiology, Pancreatic Hormones administration & dosage, Tablets, Enteric-Coated adverse effects
- Abstract
Many problems may arise within the gastrointestinal tract of patients with cystic fibrosis. We report a new cause of subacute intestinal obstruction due to a fibrotic stricture of the ascending colon in a child with cystic fibrosis. Treatment was with a right hemicolectomy. There has been no recurrence after nine months follow-up. Recent similar cases suggest that this new pathology is linked to the use of enteric-coated high-strength pancreatin microspheres.
- Published
- 1995
- Full Text
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27. Management of alimentary tract duplication in children.
- Author
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Stringer MD, Spitz L, Abel R, Kiely E, Drake DP, Agrawal M, Stark Y, and Brereton RJ
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- Adolescent, Child, Child, Preschool, Colon abnormalities, Colon surgery, Duodenum abnormalities, Esophagus abnormalities, Esophagus surgery, Female, Humans, Infant, Infant, Newborn, Intestine, Small abnormalities, Intestine, Small surgery, Male, Mediastinal Cyst etiology, Rectum abnormalities, Rectum surgery, Stomach abnormalities, Stomach surgery, Thoracotomy, Digestive System Abnormalities
- Abstract
Duplication of the alimentary tract is rare but potentially dangerous. Five of 72 children with alimentary tract duplication treated between 1973 and 1992 died from postoperative complications; a further ten required more than one operation. Ileal duplications were the commonest, occurring in 16 patients (22 per cent). Thoracoabdominal duplications were the most complicated and responsible for much of the overall morbidity and mortality. Surgical complications were related to the size and location of the duplication, communication with the gastrointestinal tract or vertebral canal, presence of heterotopic gastric mucosa and involvement of mesenteric vessels. Complete excision of the duplication should be possible in most cases.
- Published
- 1995
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28. Meconium ileus due to extensive intestinal aganglionosis.
- Author
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Stringer MD, Brereton RJ, Drake DP, Kiely EM, Agrawal M, Mouriquand PD, and Tam PK
- Subjects
- Biopsy, Needle, Female, Hirschsprung Disease pathology, Humans, Infant, Newborn, Intestine, Small pathology, Male, Rectum pathology, Hirschsprung Disease complications, Intestinal Obstruction etiology, Meconium
- Abstract
Seven full-term infants with aganglionosis extending into the small bowel presented with clinical, radiological, and operative features of meconium ileus. Misdiagnosis resulted in inappropriate treatment. The correct diagnosis was eventually established by rectal suction biopsy, mostly after either recurrent intestinal obstruction or stomal dysfunction, and after cystic fibrosis had been excluded. For two patients, the results of rectal suction biopsies were initially misleading. Two infants died. Extensive intestinal aganglionosis should be considered a rare possibility in all infants with meconium ileus. In such cases, histological examination of the appendix may avoid this potential pitfall.
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- 1994
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29. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis.
- Author
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Oades PJ, Bush A, Ong PS, and Brereton RJ
- Subjects
- Cecum pathology, Child, Preschool, Colon pathology, Constriction, Pathologic chemically induced, Drug Combinations, Fibrosis chemically induced, Humans, Male, Amylases adverse effects, Bromelains adverse effects, Cystic Fibrosis complications, Intestinal Obstruction etiology, Lipase adverse effects, Trypsin adverse effects
- Published
- 1994
30. Postoperative elective ventilation in babies with "marked anastomotic tension" after repair of esophageal atresia.
- Author
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Chittmittrapap S, Spitz L, Brereton RJ, and Kiely EM
- Subjects
- Anastomosis, Surgical, Humans, Infant, Postoperative Care, Retrospective Studies, Esophageal Atresia surgery, Esophagus surgery, Respiration, Artificial
- Abstract
The repair of esophageal atresia, preserving the patient's own esophagus is the surgical procedure of choice. In "long-gap" type or in "tension anastomosis" cases, anastomotic complications were known to be higher than in usual cases. From this report, postoperative elective ventilation for 5 days together with neck flexion position reduced such complications with minimal subsequent complications related to the mechanical ventilation.
- Published
- 1993
31. Aortopexy for tracheomalacia in oesophageal anomalies.
- Author
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Corbally MT, Spitz L, Kiely E, Brereton RJ, and Drake DP
- Subjects
- Airway Obstruction congenital, Airway Obstruction mortality, Cause of Death, Child, Child, Preschool, Esophageal Atresia mortality, Female, Follow-Up Studies, Humans, Infant, Male, Postoperative Complications mortality, Sternum surgery, Tracheal Stenosis congenital, Tracheal Stenosis mortality, Tracheoesophageal Fistula congenital, Tracheoesophageal Fistula mortality, Treatment Outcome, Airway Obstruction surgery, Aorta, Thoracic surgery, Esophageal Atresia surgery, Tracheal Stenosis surgery, Tracheoesophageal Fistula surgery
- Abstract
Forty-eight patients with repaired congenital oesophageal anomaly underwent aortopexy for significant tracheomalacia between 1980 and 1990. Indications for aortopexy included recurrent apnoea/cyanosis in 31, near fatal episodes in 16, recurrent respiratory distress and infection in 20 and worsening stridor in 15. Gastro-oesophageal reflux was noted in 30 patients, recurrent fistula in 6 and oesophageal stricture in 14. Aortopexy cured near fatal episodes in all patients and resulted in improvement of airway obstruction in 95%. The procedure failed in 2 patients due to unrecognised bronchomalacia and phrenic nerve palsy respectively. Aortopexy is the primary procedure of choice for significant tracheomalacia when associated with near fatal episodes and significant airway obstruction.
- Published
- 1993
- Full Text
- View/download PDF
32. Increased expression of muscular neural cell adhesion molecule in congenital aganglionosis.
- Author
-
Romanska HM, Bishop AE, Brereton RJ, Spitz L, and Polak JM
- Subjects
- Child, Child, Preschool, Female, Ganglia chemistry, Ganglia pathology, Histocytochemistry, Humans, Infant, Intestines pathology, Male, Muscle, Smooth chemistry, Muscle, Smooth pathology, Muscles pathology, Nerve Fibers chemistry, Nerve Fibers pathology, Thiolester Hydrolases analysis, Ubiquitin Thiolesterase, Cell Adhesion Molecules, Neuronal analysis, Hirschsprung Disease pathology, Intestines chemistry, Muscles chemistry
- Abstract
Background: Neural cell adhesion molecule (NCAM) is down regulated during morphogenesis and innervation of cardiac and skeletal muscle. In mature muscle, its reexpression over the entire sarcolemma occurs in response to denervation or paralysis of muscle and in some myopathies. No information is available regarding NCAM expression in human enteric muscle either in health or in disease. Our aim was to test whether NCAM is present in nerves and muscle of normal infant bowel and to determine how its expression is altered in congenital aganglionosis., Methods: Using immunocytochemistry for light microscopy, we compared the pattern of distribution of NCAM in congenitally aganglionic colon with that in colon from age-matched controls., Results: In normal colon, NCAM immunoreactivity was seen in ganglion cells and nerve fibers throughout the gut wall and, more weakly, on the inner border of the circular muscle. In aganglionic bowel, there was a marked increase in NCAM expression in muscle, particularly that of the muscularis mucosac and characteristic hypertrophied nerve bundles of the intermuscular zone and submucosa displayed immunoreactivity for NCAM., Conclusions: Abnormal expression of NCAM is, thus, a feature of congenital aganglionosis and is likely to be associated with neuromuscular dysfunction within the affected colon.
- Published
- 1993
- Full Text
- View/download PDF
33. Appendicectomy in children.
- Author
-
Brereton RJ
- Subjects
- Child, Child, Preschool, Emergencies, Humans, Professional Practice, Time Factors, Appendectomy
- Published
- 1993
- Full Text
- View/download PDF
34. Recurrent necrotizing enterocolitis.
- Author
-
Stringer MD, Brereton RJ, Drake DP, Kiely EM, Capps SN, and Spitz L
- Subjects
- Child, Child, Preschool, Enterocolitis, Pseudomembranous etiology, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Diseases etiology, Intestinal Perforation etiology, Intestinal Perforation surgery, Male, Postoperative Complications etiology, Recurrence, Retrospective Studies, Enterocolitis, Pseudomembranous surgery, Infant, Premature, Diseases surgery, Postoperative Complications surgery
- Abstract
In the decade 1981 to 1991, 16 infants developed recurrent necrotizing enterocolitis (NEC). They comprised 12 (6%) of 196 neonates referred for further management of NEC and four others referred with major congenital anomalies. Their median gestational age was 32 weeks (range, 27 to 40), median birth weight was 1,260 g (range, 790 to 3,230), and the sex distribution was equal. Recurrent NEC occurred after a median interval of 37 days (range, 11 to 163) from the onset of the initial episode. All but one of the 16 infants were either premature (n = 10) or mature with major congenital anomalies (n = 5). Nine patients had previously undergone surgery for NEC. Medical treatment was successful in 11 patients with recurrent NEC. Two infants died, both of liver failure related to parenteral nutrition; one of whom had suffered four separate episodes of NEC and was found to have a superior mesenteric artery occlusion. There was no consistent association between recurrent NEC and the type or timing of enteral feeds or the anatomical site or method of management of the original attack. The mortality of 12.5% was similar to that for primary NEC.
- Published
- 1993
- Full Text
- View/download PDF
35. Immunocytochemistry for neuronal markers shows deficiencies in conventional histology in the treatment of Hirschsprung's disease.
- Author
-
Romanska HM, Bishop AE, Brereton RJ, Spitz L, and Polak JM
- Subjects
- Calcitonin Gene-Related Peptide analysis, Child, Child, Preschool, Colon pathology, Colostomy, Enkephalin, Methionine analysis, Female, Galanin, Hirschsprung Disease surgery, Humans, Immunoenzyme Techniques, Infant, Male, Nerve Fibers pathology, Neuropeptide Y analysis, Peptides analysis, Submucous Plexus pathology, Substance P analysis, Vasoactive Intestinal Peptide analysis, Colon innervation, Hirschsprung Disease pathology, Neuropeptides analysis
- Abstract
Despite technically satisfactory operations, at least 20% of children with Hirschsprung's disease have an unsatisfactory postoperative result. A possible explanation for their symptoms is the retention of ganglionic intestine which has demonstrable abnormalities of the enteric nervous system. The distribution of intestinal neural proteins and peptides in resected colons from patients with Hirschsprung's disease (n = 10) was compared with that in normal controls (n = 5). Immunocytochemistry was performed using antisera against general markers of the enteric nervous system (PGP 9.5, NSE, NFILs, and S-100 protein) and colonic neuropeptides (VIP, GAL, SP, NPY, CGRP, and Met-ENK). The distribution and density of peptide-containing nerve fibers varied greatly from one patient to another and no consistent pattern of neural disturbances could be discerned in aganglionic colon. At the proximal limit of resection, abnormalities of enteric innervation were detected in 8 of 10 studied specimens. Although ganglion cells staining positively for general neuronal markers were present in all cases, normal populations of neural cell bodies immunoreactive for neuropeptides could be found in only 2 specimens. Enlarged submucosal nerve trunks found in the most proximal area of most specimens, displayed immunoreactivity for general nerve markers and VIP, GAL, NPY, and CGRP. The widely practised conventional histopathological assessment of the proximal limit of colonic neural abnormalities may be inadequate.
- Published
- 1993
- Full Text
- View/download PDF
36. Problems with intestinal lengthening.
- Author
-
Huskisson LJ, Brereton RJ, Kiely EM, and Spitz L
- Subjects
- Female, Humans, Infant, Newborn, Male, Postoperative Care, Postoperative Complications, Short Bowel Syndrome etiology, Intestines abnormalities, Intestines surgery
- Abstract
The surgical problems encountered in treating three infants with short-bowel syndrome are reported. The two survivors demonstrate many of the problems associated with the very short-bowel syndrome and both are dependent on parenteral nutrition despite undergoing intestinal lengthening.
- Published
- 1993
- Full Text
- View/download PDF
37. Management of esophageal atresia.
- Author
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Spitz L, Kiely E, Brereton RJ, and Drake D
- Subjects
- Anastomosis, Surgical adverse effects, Anastomosis, Surgical methods, Birth Weight, Esophageal Atresia complications, Esophageal Stenosis etiology, Female, Gastroesophageal Reflux etiology, Heart Defects, Congenital complications, Humans, Infant, Male, Recurrence, Risk Factors, Survival Rate, Tracheoesophageal Fistula complications, Esophageal Atresia surgery, Tracheoesophageal Fistula surgery
- Abstract
A total of 303 infants with esophageal atresia and/or tracheoesophageal fistula were treated over 10 years (1980-1989). The overall survival rate was 86.5%. Associated anomalies were identified in 51.8% of patients, the most common being cardiac malformations which affected 24.4% of infants and was responsible for the majority of deaths. The dramatic increase in survival of infants with esophageal atresia in the past half century is due to improvements in pre- and postoperative management, meticulous operative technique to reduce anastomotic complications, and aggressive treatment of associated congenital anomalies.
- Published
- 1993
- Full Text
- View/download PDF
38. Operation for gastro-oesophageal reflux associated with severe mental retardation.
- Author
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Spitz L, Roth K, Kiely EM, Brereton RJ, Drake DP, and Milla PJ
- Subjects
- Age Factors, Child, Child, Preschool, Female, Follow-Up Studies, Gastric Fundus surgery, Gastroesophageal Reflux complications, Humans, Male, Quality of Life, Reoperation, Retrospective Studies, Treatment Outcome, Gastroesophageal Reflux surgery, Intellectual Disability complications, Postoperative Complications
- Abstract
One hundred and seventy six children with severe mental retardation underwent a fundoplication for considerable gastro-oesophageal reflux. There were six 'early' (3%) deaths and five 'late' deaths. Major complications developed in 17 (10%) children whereas 86 (49%) had 'minor' complications. A revision operation was required in 27 patients. Overall 142 (81%) children achieved a good result. In spite of the high complication rate and the need for a secondary operation in 15% of the patients, the quality of life for these children and their parents and carers is greatly improved by antireflux surgery.
- Published
- 1993
- Full Text
- View/download PDF
39. Muscle-sparing lateral thoracotomy has much to recommend it in neonates.
- Author
-
Brereton RJ and Goh DW
- Subjects
- Humans, Infant, Newborn, Thoracotomy methods
- Published
- 1992
- Full Text
- View/download PDF
40. Paediatric intussusception.
- Author
-
Stringer MD, Pablot SM, and Brereton RJ
- Subjects
- Acute Disease, Chronic Disease, Humans, Infant, Infant, Newborn, Intestinal Obstruction etiology, Intussusception complications, Intussusception diagnosis, Intussusception etiology, Intussusception mortality, Intussusception pathology, Recurrence, Intussusception therapy
- Abstract
Intussusception is one of the commonest causes of intestinal obstruction in infants and accounts for about 700 hospital admissions each year in England and Wales. Improved results of treatment have followed recent technological developments, which include ultrasonographic imaging and pneumatic reduction techniques. Most intussusceptions can be reduced successfully without the need for operation but close cooperation between surgeon and radiologist is essential. Mortality and morbidity rates from the condition have progressively declined in recent decades but avoidable deaths still occur.
- Published
- 1992
- Full Text
- View/download PDF
41. Preschool screening for cryptorchidism.
- Author
-
Morecroft JA and Brereton RJ
- Subjects
- Child, Preschool, Humans, Male, Mass Screening, Risk Factors, Testicular Neoplasms prevention & control, Cryptorchidism diagnosis
- Published
- 1992
- Full Text
- View/download PDF
42. Intussusception and duodenal stenosis: an infrequent but expected association.
- Author
-
Ward HC and Brereton RJ
- Subjects
- Child, Preschool, Duodenal Obstruction surgery, Duodenostomy, Humans, Ileal Diseases surgery, Infant, Intussusception surgery, Male, Postoperative Complications surgery, Reoperation, Duodenal Obstruction congenital, Ileal Diseases congenital, Intussusception congenital
- Abstract
Two boys with intussusception, intestinal malrotation and duodenal stenosis are reported. Because intussusception is associated with malrotation, which is in turn associated with duodenal stenosis, this combination of abnormalities may be expected in up to 3% of children with intussusception.
- Published
- 1992
- Full Text
- View/download PDF
43. Delayed surgery for congenital diaphragmatic hernia.
- Author
-
Goh DW, Drake DP, Brereton RJ, Kiely EM, and Spitz L
- Subjects
- Female, Hernia, Diaphragmatic mortality, Hernias, Diaphragmatic, Congenital, Humans, Infant, Newborn, Infant, Premature, Male, Postoperative Period, Respiration, Artificial, Time Factors, Treatment Outcome, Hernia, Diaphragmatic surgery
- Abstract
Between January 1987 and December 1990, 67 neonates were treated for congenital diaphragmatic hernia, symptomatic within 6 h of birth. The mortality rate was 33 per cent. Preoperative stabilization was achieved in 47 patients, all of whom survived initial treatment, although two died later. Stabilization could not be achieved in 20 neonates, all of whom died within 3 days of birth, 18 without undergoing operation and two after early repair. Intensive resuscitation with controlled, delayed operation for congenital diaphragmatic hernia gives long-term results similar to those of urgent operative repair. This approach avoids operation in the majority of those who subsequently die.
- Published
- 1992
- Full Text
- View/download PDF
44. Congenital esophageal stenosis due to tracheobronchial remnants: a rare but important association with esophageal atresia.
- Author
-
Yeung CK, Spitz L, Brereton RJ, Kiely EM, and Leake J
- Subjects
- Adolescent, Child, Child, Preschool, Esophageal Stenosis etiology, Female, Humans, Infant, Male, Bronchial Diseases complications, Esophageal Atresia complications, Esophageal Diseases complications, Esophageal Stenosis congenital, Tracheal Diseases complications, Tracheoesophageal Fistula complications
- Abstract
Congenital esophageal stenosis caused by tracheobronchial remnants occurred in eight children, six of whom had associated esophageal atresia and/or tracheoesophageal fistula. Symptoms usually began in early infancy but delayed diagnosis was a common feature. The mean lag period between presentation and definitive operation was 4.6 years (range, 1 month to 16 years). Errors in diagnosis were common. Six were initially diagnosed as having inflammatory strictures secondary to reflux esophagitis. Seven children were subjected to repeated esophagoscopy and bouginage of the "stricture" (mean no. = 3.4), with invariable failure to ameliorate dysphagia. Antireflux procedures were performed in three patients. In all children, symptoms were dramatically relieved following resection of the stenotic segment or esophageal replacement. Although a rare entity, congenital esophageal stenosis due to tracheobronchial remnants should be considered a possibility in patients with esophageal stricture, presumed to be inflammatory in nature, which fails to respond to standard therapy.
- Published
- 1992
- Full Text
- View/download PDF
45. Midgut malrotation associated with hypertrophic pyloric stenosis had concomitant congenital short bowel.
- Author
-
Brereton RJ
- Subjects
- Humans, Hypertrophy, Infant, Newborn, Intestinal Obstruction complications, Pyloric Stenosis complications, Short Bowel Syndrome complications
- Published
- 1992
- Full Text
- View/download PDF
46. Double duodenal atresia/stenosis: a report of four cases.
- Author
-
Stringer MD, Brereton RJ, Drake DP, and Wright VM
- Subjects
- Abnormalities, Multiple surgery, Anastomosis, Surgical methods, Duodenal Obstruction diagnosis, Duodenal Obstruction etiology, Duodenal Obstruction surgery, Duodenostomy, Duodenum surgery, Female, Humans, Infant, Newborn, Intestinal Atresia complications, Intestinal Atresia surgery, Jejunum surgery, Male, Abnormalities, Multiple diagnosis, Duodenal Obstruction congenital, Duodenum abnormalities, Intestinal Atresia diagnosis
- Abstract
Four neonates with double duodenal atresia/stenosis are described. Preoperative plain radiographs in two patients demonstrated atypical appearances suggestive of complex pathology. Cystic dilatation of the second part of the duodenum was observed at laparotomy in two patients and in one of these the "cyst" was palpable preoperatively, causing diagnostic confusion. All four patients underwent successful surgery but one infant with Down's syndrome subsequently died of congenital heart disease.
- Published
- 1992
- Full Text
- View/download PDF
47. CHARGE and esophageal atresia.
- Author
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Kutiyanawala M, Wyse RK, Brereton RJ, Spitz L, Kiely EM, Drake D, and Blake K
- Subjects
- Choanal Atresia diagnosis, Coloboma diagnosis, Deafness diagnosis, Esophageal Atresia diagnosis, Female, Growth Disorders diagnosis, Heart Defects, Congenital diagnosis, Humans, Hypogonadism diagnosis, Infant, Infant, Newborn, Male, Tracheoesophageal Fistula diagnosis, Abnormalities, Multiple diagnosis, Choanal Atresia complications, Coloboma complications, Deafness complications, Ear, External abnormalities, Esophageal Atresia complications, Growth Disorders complications, Heart Defects, Congenital complications, Hypogonadism complications, Tracheoesophageal Fistula complications
- Abstract
CHARGE association was diagnosed in 61 infants, 20 of whom died, mainly during the first 2 years of life. Esophageal atresia and/or tracheoesophageal fistula were present in 10 neonates. Axial skeletal anomalies occurred in 7 of the 10, but none had preaxial limb defects typical of the VATER association. All had major cardiac anomalies, predominantly tetralogy of Fallot. The majority of patients had primary repair of the esophagus. The postoperative course was stormy in all patients, with a high incidence of complications and 70% died. The recognition of features of the CHARGE association is important because it has major prognostic and therapeutic implications.
- Published
- 1992
- Full Text
- View/download PDF
48. Morphine for pain in infants.
- Author
-
Brereton RJ
- Subjects
- Humans, Infant, Newborn, Respiratory Insufficiency chemically induced, Narcotics adverse effects
- Published
- 1992
- Full Text
- View/download PDF
49. Anastomotic leakage following surgery for esophageal atresia.
- Author
-
Chittmittrapap S, Spitz L, Kiely EM, and Brereton RJ
- Subjects
- Anastomosis, Surgical, Esophageal Stenosis epidemiology, Humans, Infant, Newborn, Proteins, Reoperation, Risk Factors, Silk, Sutures, Esophageal Atresia surgery, Esophagus surgery, Insect Proteins, Postoperative Complications epidemiology
- Abstract
Of 199 neonates undergoing primary or delayed primary repair of esophageal atresia, 34 (17%) developed anastomotic leakage, 7 of which (3.5%) were major anastomotic disruptions. Infants with major leaks developed signs within 5 days and all required early reoperation, necessitating abandonment of the esophagus in 6. The remaining 27 were minor leaks demonstrated by water-soluble contrast studies and were successfully treated nonoperatively. Gastroesophageal reflux was unassociated with this complication but the use of braided silk sutures was associated with a significantly increased risk of anastomotic leakage when compared with polyglycolic acid (relative risk, 3.2) or polypropylene (relative risk, 2.6) sutures. Following anastomotic leakage there was a significantly increased risk (relative risk, 2.04) of subsequent esophageal stricture formation.
- Published
- 1992
- Full Text
- View/download PDF
50. Triangle of auscultation thoracotomy for esophageal atresia.
- Author
-
Goh DW and Brereton RJ
- Subjects
- Humans, Infant, Newborn, Esophageal Atresia surgery, Thoracotomy methods
- Abstract
A technique of thoracotomy via the triangle of auscultation is described. It avoids the division of latissimus dorsi, serratus anterior, and trapezius muscles, with its consequent morbidity, and provides excellent access to the thoracic cavity and the posterior aspect of the mediastinum.
- Published
- 1992
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