2,854 results on '"Brewer, J."'
Search Results
2. IL-10 constrains sphingolipid metabolism to limit inflammation.
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Flavell, Richard, York, Autumn, Skadow, Mathias, Oh, Joonseok, Qu, Rihao, Zhou, Quan, Hsieh, Wei-Yuan, Mowel, Walter, Brewer, J, Kaffe, Eleanna, Williams, Kevin, Kluger, Yuval, Smale, Stephen, Crawford, Jason, and Bensinger, Steven
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Animals ,Humans ,Mice ,Ceramides ,Fatty Acids ,Unsaturated ,Homeostasis ,Immunity ,Innate ,Inflammation ,Interleukin-10 ,Proto-Oncogene Proteins c-rel ,Sphingolipids - Abstract
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell activation and cytokine production in innate immune cell types1. Loss of IL-10 signalling results in life-threatening inflammatory bowel disease in humans and mice-however, the exact mechanism by which IL-10 signalling subdues inflammation remains unclear2-5. Here we find that increased saturated very long chain (VLC) ceramides are critical for the heightened inflammatory gene expression that is a hallmark of IL-10 deficiency. Accordingly, genetic deletion of ceramide synthase 2 (encoded by Cers2), the enzyme responsible for VLC ceramide production, limited the exacerbated inflammatory gene expression programme associated with IL-10 deficiency both in vitro and in vivo. The accumulation of saturated VLC ceramides was regulated by a decrease in metabolic flux through the de novo mono-unsaturated fatty acid synthesis pathway. Restoring mono-unsaturated fatty acid availability to cells deficient in IL-10 signalling limited saturated VLC ceramide production and the associated inflammation. Mechanistically, we find that persistent inflammation mediated by VLC ceramides is largely dependent on sustained activity of REL, an immuno-modulatory transcription factor. Together, these data indicate that an IL-10-driven fatty acid desaturation programme rewires VLC ceramide accumulation and aberrant activation of REL. These studies support the idea that fatty acid homeostasis in innate immune cells serves as a key regulatory node to control pathologic inflammation and suggests that metabolic correction of VLC homeostasis could be an important strategy to normalize dysregulated inflammation caused by the absence of IL-10.
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- 2024
3. Effects of Oak Woodland Restoration Treatments on Sapling Survival and Tree Recruitment of Oaks in an Upland Mesic Oak-dominated Forest
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Brewer, J. Stephen
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- 2014
4. Using the Socioecological Model to Understand Medical Staff and Older Adult Patients’ Experience with Chronic Pain: A Qualitative Study in an Underserved Community Setting
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McDermott K, Presciutti AM, Levey N, Brewer J, Rush CL, Giraldo-Santiago N, Pham TV, Pasinski R, Yousif N, Gholston M, Raju V, Greenberg J, Ritchie CS, and Vranceanu AM
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community clinic ,pain ,health disparities ,Medicine (General) ,R5-920 - Abstract
Katherine McDermott,1,2 Alexander Mattia Presciutti,1,2 Nadine Levey,1 Julie Brewer,1 Christina L Rush,1,2 Natalia Giraldo-Santiago,1,3 Tony V Pham,1,2 Roger Pasinski,4 Neda Yousif,4 Milton Gholston,4 Vidya Raju,4 Jonathan Greenberg,1,3 Christine S Ritchie,2,3 Ana-Maria Vranceanu1,2 1Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA; 3Center for Aging and Serious Illness, Massachusetts General Hospital, Boston, MA, USA; 4MGH Revere HealthCare Center, Revere, MA, USACorrespondence: Ana-Maria Vranceanu, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, One Bowdoin Square, 1st Floor, Suite 100, Boston, MA, 02114, USA, Email avranceanu@mgh.harvard.eduPurpose: Chronic pain is highly prevalent and disabling for older adults, particularly those from underserved communities. However, there is an absence of research on how contextual (eg, community/societal) factors interact with pain for these patients. Informed by the socio-ecological model, this study aimed to elucidate the individual, interpersonal, community, and societal factors associated with chronic pain from the perceptions of older adult patients and medical staff in a community clinic.Patients and Methods: In this qualitative study, we conducted four focus groups and two interviews with medical staff (n=25) and three focus groups and seven individual interviews with older adult patients with chronic pain (n=18). Participants were recruited using purposive sampling from an ethnically and economically diverse primary care clinic in the greater Boston community. We transcribed assessments and thematically analyzed data using a hybrid deductive-inductive approach.Results: At the individual level, we identified three themes: (1) older adults with complex care needs, (2) impact of pain (including on physical, emotional, work, and identity functioning), and (3) coping with pain. At the interpersonal level, complex relationships with (1) social supports and (2) medical staff emerged as themes. The need for (1) resources and (2) culturally informed care was identified at the community level, and socioeconomic status impacting the availability of resources for managing chronic pain emerged for the societal domain.Conclusion: Findings underscore the intersection of factors contributing to the experience of pain among older adults from underserved communities. Our findings highlight the need to develop and implement treatments that fully address the experience of older adults with chronic pain at the individual, interpersonal, community, and societal levels.Keywords: community clinic, pain, health disparities
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- 2024
5. IL-10 constrains sphingolipid metabolism to limit inflammation
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York, Autumn G., Skadow, Mathias H., Oh, Joonseok, Qu, Rihao, Zhou, Quan D., Hsieh, Wei-Yuan, Mowel, Walter K., Brewer, J. Richard, Kaffe, Eleanna, Williams, Kevin J., Kluger, Yuval, Smale, Stephen T., Crawford, Jason M., Bensinger, Steven J., and Flavell, Richard A.
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- 2024
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6. The Duel of Magnetic Interactions & Structural Instabilities: Itinerant Frustration in the Triangular Lattice Compound LiCrSe$_2$
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Nocerino, E., Kobayashi, S., Witteveen, C., Forslund, O. K., Matsubara, N., Tang, C., Matsukawa, T., Hoshikawa, A., Koda, A., Yoshimura, K., Umegaki, I., Sassa, Y., von Rohr, F. O., Pomjakushin, V., Brewer, J. H., Sugiyama, J., and Månsson, M.
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Condensed Matter - Strongly Correlated Electrons - Abstract
The recent synthesis of the chromium selenide compound LiCrSe$_2$ constitutes a valuable addition to the ensemble of two-dimensional triangular lattice antiferromagnets (2D-TLA). In this work we present the very first comprehensive study of the combined low temperature nuclear and magnetic structure established in this material. Details on the connection between Li-ion dynamics and structural changes are also presented along with a direct link between atomic structure and spin order via a strong magnetoelastic coupling. LiCrSe$_2$ was found to undergo a first order structural transition from a trigonal crystal system with space group $P\bar{3}m1$ to a monoclinic one with space group $C2/m$ at $T_{\rm s}=30$~K. Such restructuring of the lattice is accompanied by a magnetic transition at $T_{\rm N}=30$~K, with the formation of a complex spin arrangement for the Cr$^{3+}$ moments. Refinement of the magnetic structure with neutron diffraction data and complementary muon spin rotation analysis reveal the presence of two incommensurate magnetic domains with a up-up-down-down arrangement of the spins with ferromagnetic (FM) double chains coupled antiferromagnetically (AFM). In addition to this unusual arrangement, the spin axial vector is modulated both in direction and modulus, resulting in a spin density wave-like order with periodic suppression of the Cr moment along the chains. This behavior is believed to appear as a result of strong competition between direct exchange AFM and superexchange FM couplings established between both nearest neighbor and next nearest neighbor Cr$^{3+}$ ions. We finally conjecture that the resulting magnetic order is stabilized via subtle vacancy/charge order within the Li layers, potentially causing a mix of two different magnetic phases within the sample.
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- 2022
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7. Technique for Weaning From Peripheral Venopulmonary Extracorporeal Membrane Oxygenation in Combined Cardiopulmonary Failure
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Brewer, J. Michael and Maybauer, Marc O.
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- 2024
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8. Venopulmonary Extracorporeal Membrane Oxygenation and the Importance of Nomenclature Adherence for an Emerging Mode
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Saha, Biplab K., Brewer, J. Michael, and Maybauer, Marc O.
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- 2024
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9. Study of muonium emission from laser-ablated silica aerogel
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Beare, J., Beer, G., Brewer, J. H., Iijima, T., Ishida, K., Iwasaki, M., Kamal, S., Kanamori, K., Kawamura, N., Kitamura, R., Li, S., Luke, G. M., Marshall, G. M., Mibe, T., Miyake, Y., Oishi, Y., Olchanski, K., Olin, A., Otani, M., Rehman, M. A., Saito, N., Sato, Y., Shimomura, K., Suzuki, K., Tabata, M., and Yasuda, H.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The emission of muonium ($\mu^+e^-$) atoms into vacuum from silica aerogel with laser ablation on its surface was studied with various ablation structures at room temperature using the subsurface muon beams at TRIUMF and Japan Proton Accelerator Research Complex (J-PARC). Laser ablation was applied to produce holes or grooves with typical dimensions of a few hundred $\mu$m to a few mm, except for some extreme conditions. The measured emission rate tends to be higher for larger fractions of ablation opening and for shallower depths. More than a few ablation structures reach the emission rates similar to the highest achieved in the past measurements. The emission rate is found to be stable at least for a couple of days. Measurements of spin precession amplitudes for the produced muonium atoms and remaining muons in a magnetic field determine a muonium formation fraction of $(65.5 \pm 1.8)$%. The precession of the polarized muonium atoms is also observed clearly in vacuum. A projection of the emission rates measured at TRIUMF to the corresponding rates at J-PARC is demonstrated taking the different beam condition into account reasonably., Comment: 34 pages, 13 figures, submitted to PTEP
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- 2020
10. Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer’s Disease
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Kellar, D, Lockhart, SN, Aisen, P, Raman, R, Rissman, RA, Brewer, J, and Craft, Suzanne
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Alzheimer's Disease ,Brain Disorders ,Clinical Research ,Dementia ,Neurodegenerative ,Aging ,Behavioral and Social Science ,Acquired Cognitive Impairment ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurosciences ,Clinical Trials and Supportive Activities ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Neurological ,Activities of Daily Living ,Administration ,Intranasal ,Aged ,Alzheimer Disease ,Biomarkers ,Brain ,Cognition ,Cognitive Dysfunction ,Female ,Humans ,Hypoglycemic Agents ,Image Processing ,Computer-Assisted ,Insulin ,Insulin ,Regular ,Human ,Magnetic Resonance Imaging ,Male ,Neuropsychological Tests ,White Matter ,Alzheimer’ ,s disease ,clinical trial ,intranasal insulin ,white matter ,CSF ,Alzheimer’s disease - Abstract
BackgroundIntranasally administered insulin has shown promise in both rodent and human studies in Alzheimer's disease; however, both effects and mechanisms require elucidation.ObjectiveWe assessed the effects of intranasally administered insulin on white matter health and its association with cognition and cerebral spinal fluid biomarker profiles in adults with mild cognitive impairment or Alzheimer's disease in secondary analyses from a prior phase 2 clinical trial (NCT01767909).DesignA randomized (1:1) double-blind clinical trial.SettingTwelve sites across the United States.ParticipantsAdults with mild cognitive impairment or Alzheimer's disease.InterventionParticipants received either twice daily placebo or insulin (20 IU Humulin R U-100 b.i.d.) intranasally for 12 months. Seventy-eight participants were screened, of whom 49 (32 men) were enrolled.MeasurementsChanges from baseline in global and regional white matter hyperintensity volume and gray matter volume were analyzed and related to changes in cerebral spinal fluid biomarkers, Alzheimer's Disease Assessment Scale-Cognition, Clinical Disease Rating-Sum of Boxes, Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale, and a memory composite.ResultsThe insulin-treated group demonstrated significantly reduced changes in white matter hyperintensity volume in deep and frontal regions after 12 months, with a similar trend for global volume. White matter hyperintensity volume progression correlated with worsened Alzheimer's disease cerebral spinal fluid biomarker profile and cognitive function; however, patterns of correlations differed by treatment group.ConclusionIntranasal insulin treatment for 12 months reduced white matter hyperintensity volume progression and supports insulin's potential as a therapeutic option for Alzheimer's disease.
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- 2021
11. Transmission Spectroscopy for the Warm Sub-Neptune HD 3167c: Evidence for Molecular Absorption and a Possible High-metallicity Atmosphere
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Mikal-Evans, T, Crossfield, IJM, Benneke, B, Kreidberg, L, Moses, J, Morley, CV, Thorngren, D, Molli re, P, Hardegree-Ullman, KK, Brewer, J, Christiansen, JL, Ciardi, DR, Dragomir, D, Dressing, C, Fortney, JJ, Gorjian, V, Greene, TP, Hirsch, LA, Howard, AW, Howell, SB, Isaacson, H, Kosiarek, MR, Krick, J, Livingston, JH, Lothringer, JD, Morales, FY, Petigura, EA, Schlieder, JE, and Werner, M
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Exoplanet astronomy ,Exoplanets ,Exoplanet atmospheres ,astro-ph.EP ,Astronomy & Astrophysics ,Astronomical and Space Sciences - Abstract
We present a transmission spectrum for the warm (500-600 K) sub-Neptune HD 3167c obtained using the Hubble Space Telescope Wide Field Camera 3 infrared spectrograph. We combine these data, which span the 1.125-1.643 μm wavelength range, with broadband transit measurements made using Kepler/K2 (0.6-0.9 μm) and Spitzer/IRAC (4-5 μm). We find evidence for absorption by at least one of H2O, HCN, CO2, and CH4 (Bayes factor 7.4; 2.5σ significance), although the data precision does not allow us to unambiguously discriminate between these molecules. The transmission spectrum rules out cloud-free hydrogen-dominated atmospheres with metallicities ≤100 solar at >5.8σ confidence. In contrast, good agreement with the data is obtained for cloud-free models assuming metallicities >700 solar. However, for retrieval analyses that include the effect of clouds, a much broader range of metallicities (including subsolar) is consistent with the data, due to the degeneracy with cloud-top pressure. Self-consistent chemistry models that account for photochemistry and vertical mixing are presented for the atmosphere of HD 3167c. The predictions of these models are broadly consistent with our abundance constraints, although this is primarily due to the large uncertainties on the latter. Interior structure models suggest that the core mass fraction is >40%, independent of a rock or water core composition, and independent of atmospheric envelope metallicity up to 1000 solar. We also report abundance measurements for 15 elements in the host star, showing that it has a very nearly solar composition.
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- 2021
12. K2 rotation periods for low-mass Hyads and a quantitative comparison of the distribution of slow rotators in the Hyades and Praesepe
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Douglas, S. T., Curtis, J. L., Agüeros, M. A., Cargile, P. A., Brewer, J. M., Meibom, S., and Jansen, T.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We analyze K2 light curves for 132 low-mass ($1\ \gtrsim\ M_*\ \gtrsim\ 0.1$~${M_{\odot}}$) members of the 600--800~Myr-old Hyades cluster and measure rotation periods ($P_{rot}$) for 116 of these stars. These include 93 stars with no prior $P_{rot}$ measurement; the total number of Hyads with known $P_{rot}$ is now 232. We then combine literature binary data with Gaia DR2 photometry and astrometry to select single star sequences in the Hyades and its roughly coeval Praesepe open cluster, and derive a new reddening value of $A_V = 0.035$$\pm$$0.011$ for Praesepe. Comparing the effective temperature--$P_{rot}$ distributions for the Hyades and Praesepe, we find that solar-type Hyads rotate, on average, 0.4~d slower than their Praesepe counterparts. This $P_{rot}$ difference indicates that the Hyades is slightly older than Praesepe: we apply a new gyrochronology model tuned with Praesepe and the Sun, and find an age difference between the two clusters of 57~Myr. However, this $P_{rot}$ difference decreases and eventually disappears for lower-mass stars. This provides further evidence for stalling in the rotational evolution of these stars, and highlights the need for more detailed analysis of angular-momentum evolution for stars of different masses and ages., Comment: Accepted for publication in ApJ. 20 pages, 10 figures, 5 tables. CSV versions of tables 2, 3, and 4 available by request
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- 2019
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13. Use of Formal and Informal Food Resources by Food Insecure Families in Lima, Peru : A Mixed-Methods Analysis
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Brewer, J. D., Santos, M. P., Lopez, M. A., Paz-Soldan, V. A., and Chaparro, M. P.
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- 2021
14. Plant behavior and coexistence : stem elongation of the carnivorous subshrub Drosophyllum lusitanicum within xerophytic shrub canopies
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Brewer, J. Stephen, Paniw, Maria, and Ojeda, Fernando
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- 2021
15. Inflammasome activation in infected macrophages drives COVID-19 pathology
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Sefik, Esen, Qu, Rihao, Junqueira, Caroline, Kaffe, Eleanna, Mirza, Haris, Zhao, Jun, Brewer, J. Richard, Han, Ailin, Steach, Holly R., Israelow, Benjamin, Blackburn, Holly N., Velazquez, Sofia E., Chen, Y. Grace, Halene, Stephanie, Iwasaki, Akiko, Meffre, Eric, Nussenzweig, Michel, Lieberman, Judy, Wilen, Craig B., Kluger, Yuval, and Flavell, Richard A.
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- 2022
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16. Technique for Weaning From Peripheral Venopulmonary Extracorporeal Membrane Oxygenation in Combined Cardiopulmonary Failure.
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Brewer, J. Michael and Maybauer, Marc O.
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- 2025
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17. Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials.
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Long, Micah T., Krause, Bryan M., de Jong, Audrey, Dollerschell, John T., Brewer, J. Michael, Casey, Jonathan D., Gaillard, John P., Gandotra, Sheetal, Ghamande, Shekhar A., Gibbs, Kevin W., Ginde, Adit A., Hughes, Christopher G., Janz, David R., Khan, Akram, Latimer, Andrew, Mitchell, Steven, Page, David B., Russell, Derek W., Self, Wesley H., and Semler, Matthew W.
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- 2025
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18. The Yale-Potsdam Stellar Isochrones (YaPSI)
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Spada, F., Demarque, P., Kim, Y. -C., Boyajian, T. S., and Brewer, J. M.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We introduce the Yale-Potsdam Stellar Isochrones (YaPSI), a new grid of stellar evolution tracks and isochrones of solar-scaled composition. In an effort to improve the Yonsei-Yale database, special emphasis is placed on the construction of accurate low-mass models (Mstar < 0.6 Msun), and in particular of their mass-luminosity and mass-radius relations, both crucial in characterizing exoplanet-host stars and, in turn, their planetary systems. The YaPSI models cover the mass range 0.15 to 5.0 Msun, densely enough to permit detailed interpolation in mass, and the metallicity and helium abundance ranges [Fe/H] = -1.5 to +0.3, and Y = 0.25 to 0.37, specified independently of each other (i.e., no fixed Delta Y/Delta Z relation is assumed). The evolutionary tracks are calculated from the pre-main sequence up to the tip of the red giant branch. The isochrones, with ages between 1 Myr and 20 Gyr, provide UBVRI colors in the Johnson-Cousins system, and JHK colors in the homogeneized Bessell & Brett system, derived from two different semi-empirical Teff-color calibrations from the literature. We also provide utility codes, such as an isochrone interpolator in age, metallicity, and helium content, and an interface of the tracks with an open-source Monte Carlo Markov-Chain tool for the analysis of individual stars. Finally, we present comparisons of the YaPSI models with the best empirical mass- luminosity and mass-radius relations available to date, as well as isochrone fitting of well-studied ste, Comment: 17 pages, 14 figures; accepted for publication in the Astrophysical Journal
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- 2017
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19. Mesophication of Oak Landscapes : Evidence, Knowledge Gaps, and Future Research
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ALEXANDER, HEATHER D., SIEGERT, COURTNEY, BREWER, J. STEPHEN, KREYE, JESSE, LASHLEY, MARCUS A., MCDANIEL, JENNIFER K., PAULSON, ALISON K., RENNINGER, HEIDI J., and VARNER, J. MORGAN
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- 2021
20. Fire Ecology and Fire Management of Southeastern Coastal Plain Pine Ecosystems
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Glitzenstein, Jeff S., Brewer, J. Stephen, Masters, Ronald E., Varner, J. Morgan, Hiers, J. Kevin, Tomé, Margarida, Series Editor, Seifert, Thomas, Series Editor, Kurttila, Mikko, Series Editor, Greenberg, Cathryn H., editor, and Collins, Beverly, editor
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- 2021
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21. The POCUS Consult: How Point of Care Ultrasound Helps Guide Medical Decision Making
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Rice JA, Brewer J, Speaks T, Choi C, Lahsaei P, and Romito BT
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hemodynamics ,trauma ,respiratory failure ,hypotension ,Medicine (General) ,R5-920 - Abstract
Jake A Rice,1,2 Jonathan Brewer,2 Tyler Speaks,1 Christopher Choi,1 Peiman Lahsaei,1 Bryan T Romito1 1Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USACorrespondence: Bryan T RomitoDepartment of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9068, USATel +1 214 648 7674Fax +1 214 648 5461Email Bryan.Romito@UTSouthwestern.eduAbstract: Point of care ultrasound (POCUS) allows for rapid, real-time evaluation of cardiovascular and respiratory pathology. The advent of portable, handheld devices and increased recognition by accrediting bodies of the importance of POCUS in guiding clinical decision making has expanded its use across the hospital setting and within medical training programs. POCUS allows clinicians to begin immediate investigation into their differential diagnoses without waiting for a formal imaging study, enhancing the speed of clinical interpretation. In addition to its diagnostic utility, POCUS can also inform clinicians of patients’ response to interventions when serial exams are obtained. This review examines the role of POCUS in the context of frequently encountered patients and highlights the key clinical questions that can be readily answered by POCUS.Keywords: hemodynamics, trauma, respiratory failure, hypotension
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- 2021
22. String-Theory-Based Predictions for Nonhydrodynamic Collective Modes in Strongly Interacting Fermi Gases
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Bantilan, H., Brewer, J. T., Ishii, T., Lewis, W. E., and Romatschke, P.
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Condensed Matter - Quantum Gases ,High Energy Physics - Theory ,Nuclear Theory - Abstract
Very different strongly interacting quantum systems such as Fermi gases, quark-gluon plasmas formed in high energy ion collisions and black holes studied theoretically in string theory are known to exhibit quantitatively similar damping of hydrodynamic modes. It is not known if such similarities extend beyond the hydrodynamic limit. Do non-hydrodynamic collective modes in Fermi gases with strong interactions also match those from string theory calculations? In order to answer this question, we use calculations based on string theory to make predictions for novel types of modes outside the hydrodynamic regime in trapped Fermi gases. These predictions are amenable to direct testing with current state-of-the-art cold atom experiments., Comment: 8 pages, 2 figures, 2 tables; v2: matches published version
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- 2016
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23. Planet Hunters X. KIC 8462852 - Where's the Flux?
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Boyajian, T. S., LaCourse, D. M., Rappaport, S. A., Fabrycky, D., Fischer, D. A., Gandolfi, D., Kennedy, G. M., Korhonen, H., Liu, M. C., Moor, A., Olah, K., Vida, K., Wyatt, M. C., Best, W. M. J., Brewer, J., Ciesla, F., Csak, B., Deeg, H. J., Dupuy, T. J., Handler, G., Heng, K., Howell, S. B., Ishikawa, S. T., Kovacs, J., Kozakis, T., Kriskovics, L., Lehtinen, J., Lintott, C., Lynn, S., Nespral, D., Nikbakhsh, S., Schawinski, K., Schmitt, J. R., Smith, A. M., Szabo, Gy., Szabo, R., Viuho, J., Wang, J., Weiksnar, A., Bosch, M., Connors, J. L., Goodman, S., Green, G., Hoekstra, A. J., Jebson, T., Jek, K. J., Omohundro, M. R., Schwengeler, H. M., and Szewczyk, A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Over the duration of the Kepler mission, KIC8462852 was observed to undergo irregularly shaped, aperiodic dips in flux of up to $\sim 20$\%. The dipping activity can last for between 5 and 80 days. We characterize the object with high-resolution spectroscopy, spectral energy distribution fitting, radial velocity measurements, high-resolution imaging, and Fourier analyses of the Kepler light curve. We determine that KIC8462852 is a typical main-sequence F3 V star that exhibits no significant IR excess, and has no very close interacting companions. In this paper, we describe various scenarios to explain the dipping events observed in the Kepler light curve. We confirm that the dipping signals in the data are not caused by any instrumental or data processing artifact, and thus are astrophysical in origin. We construct scenario-independent constraints on the size and location of a body in the system that is needed to reproduce the observations. We deliberate over several assorted stellar and circumstellar astrophysical scenarios, most of which have problems explaining the data in hand. By considering the observational constraints on dust clumps in orbit around a normal main-sequence star, we conclude that the scenario most consistent with the data in hand is the passage of a family of exocomet or planetesimal fragments, all of which are associated with a single previous break-up event, possibly caused by tidal disruption or thermal processing. The minimum total mass associated with these fragments likely exceeds $10^{-6}$~\mearth, corresponding to an original rocky body of $>100$~km in diameter. We discuss the necessity of future observations to help interpret the system., Comment: Accepted for publication in MNRAS. 17 pages, 13 figures
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- 2015
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24. Standardized nomenclature for peripheral percutaneous cannulation of the pulmonary artery in extracorporeal membrane oxygenation: Current uptake and recommendations for improvement.
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Brewer, J Michael, Broman, L Mikael, Swol, Justyna, Lorusso, Roberto, Conrad, Steven A, and Maybauer, Marc O
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MEDICAL protocols , *EXTRACORPOREAL membrane oxygenation , *TERMS & phrases , *PULMONARY artery , *INTRAVENOUS catheterization , *LIFE support systems in critical care - Abstract
The rising application of extracorporeal membrane oxygenation (ECMO) has emphasized the need for consistent and standardized terminology, especially concerning peripheral percutaneous cannulation of the pulmonary artery (PPC-PA). The Extracorporeal Life Support Organization (ELSO) Nomenclature Task Force produced the ELSO Maastricht Treaty for extracorporeal life support (ECLS) Nomenclature to address this challenge. However, adherence to nomenclature recommendations has been poor in publications describing PPC-PA. We aim to describe common nomenclature errors and provide a user-guide for abbreviations that can be used by authors, reviewers, and journal staff to ensure properadherence to standardized nomenclature in publications describing PPC-PA. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Central Venopulmonary Extracorporeal Membrane Oxygenation: Background and Standardized Nomenclature.
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BREWER, J. MICHAEL, LORUSSO, ROBERTO, BROMAN, L. MIKAEL, CONRAD, STEVEN A., SWOL, JUSTYNA, and MAYBAUER, MARC O.
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- 2024
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26. KOI-3158: The oldest known system of terrestrial-size planets
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Campante, T. L., Barclay, T., Swift, J. J., Huber, D., Adibekyan, V. Zh., Cochran, W., Burke, C. J., Isaacson, H., Quintana, E. V., Davies, G. R., Aguirre, V. Silva, Ragozzine, D., Riddle, R., Baranec, C., Basu, S., Chaplin, W. J., Christensen-Dalsgaard, J., Metcalfe, T. S., Bedding, T. R., Handberg, R., Stello, D., Brewer, J. M., Hekker, S., Karoff, C., Kolbl, R., Law, N. M., Lundkvist, M., Miglio, A., Rowe, J. F., Santos, N. C., Van Laerhoven, C., Arentoft, T., Elsworth, Y. P., Fischer, D. A., Kawaler, S. D., Kjeldsen, H., Lund, M. N., Marcy, G. W., Sousa, S. G., Sozzetti, A., and White, T. R.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The first discoveries of exoplanets around Sun-like stars have fueled efforts to find ever smaller worlds evocative of Earth and other terrestrial planets in the Solar System. While gas-giant planets appear to form preferentially around metal-rich stars, small planets (with radii less than four Earth radii) can form under a wide range of metallicities. This implies that small, including Earth-size, planets may have readily formed at earlier epochs in the Universe's history when metals were far less abundant. We report Kepler spacecraft observations of KOI-3158, a metal-poor Sun-like star from the old population of the Galactic thick disk, which hosts five planets with sizes between Mercury and Venus. We used asteroseismology to directly measure a precise age of 11.2+/-1.0 Gyr for the host star, indicating that KOI-3158 formed when the Universe was less than 20% of its current age and making it the oldest known system of terrestrial-size planets. We thus show that Earth-size planets have formed throughout most of the Universe's 13.8-billion-year history, providing scope for the existence of ancient life in the Galaxy., Comment: Submitted to EPJ Web of Conferences, to appear in the Proceedings of the 3rd CoRoT Symposium, Kepler KASC7 joint meeting; 4 pages, 1 figure
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- 2015
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27. An ancient extrasolar system with five sub-Earth-size planets
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Campante, T. L., Barclay, T., Swift, J. J., Huber, D., Adibekyan, V. Zh., Cochran, W., Burke, C. J., Isaacson, H., Quintana, E. V., Davies, G. R., Aguirre, V. Silva, Ragozzine, D., Riddle, R., Baranec, C., Basu, S., Chaplin, W. J., Christensen-Dalsgaard, J., Metcalfe, T. S., Bedding, T. R., Handberg, R., Stello, D., Brewer, J. M., Hekker, S., Karoff, C., Kolbl, R., Law, N. M., Lundkvist, M., Miglio, A., Rowe, J. F., Santos, N. C., Van Laerhoven, C., Arentoft, T., Elsworth, Y. P., Fischer, D. A., Kawaler, S. D., Kjeldsen, H., Lund, M. N., Marcy, G. W., Sousa, S. G., Sozzetti, A., and White, T. R.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The chemical composition of stars hosting small exoplanets (with radii less than four Earth radii) appears to be more diverse than that of gas-giant hosts, which tend to be metal-rich. This implies that small, including Earth-size, planets may have readily formed at earlier epochs in the Universe's history when metals were more scarce. We report Kepler spacecraft observations of Kepler-444, a metal-poor Sun-like star from the old population of the Galactic thick disk and the host to a compact system of five transiting planets with sizes between those of Mercury and Venus. We validate this system as a true five-planet system orbiting the target star and provide a detailed characterization of its planetary and orbital parameters based on an analysis of the transit photometry. Kepler-444 is the densest star with detected solar-like oscillations. We use asteroseismology to directly measure a precise age of 11.2+/-1.0 Gyr for the host star, indicating that Kepler-444 formed when the Universe was less than 20% of its current age and making it the oldest known system of terrestrial-size planets. We thus show that Earth-size planets have formed throughout most of the Universe's 13.8-billion-year history, leaving open the possibility for the existence of ancient life in the Galaxy. The age of Kepler-444 not only suggests that thick-disk stars were among the hosts to the first Galactic planets, but may also help to pinpoint the beginning of the era of planet formation., Comment: Accepted for publication in ApJ; 42 pages, 10 figures, 4 tables
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- 2015
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28. THE CLINICAL EFFECTIVENESS OF A TEACHING COURSE ON THE USE OF TOTALLY EXTRAPERITONEAL APPROACH FOR INGUINAL HERNIA REPAIRS
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Mackenzie, A, primary, Chidambaram, S, additional, Howell, A M R, additional, Muirhead, L, additional, Brewer, J O L, additional, Fakih-Gomez, N, additional, Smellie, J W B, additional, and Warren, O J, additional
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- 2024
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29. Magnetic phase diagram of Sr$_{1-x}$Ca$_x$Co$_2$P$_2$
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Sugiyama, J., Nozaki, H., Umegaki, I., Harada, M., Higuchi, Y., Ansaldo, E. J., Brewer, J. H., Imai, M., Michioka, C., Yoshimura, K., and Månsson, M
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Condensed Matter - Strongly Correlated Electrons - Abstract
In order to study the phase diagram from a microscopic viewpoint, we have measured wTF- and ZF-$\mu^+$SR spectra for the Sr$_{1-x}$Ca$_x$Co$_2$P$_2$ powder samples with $x=0$, 0.2, 0.4, 0.5, 0.6, 0.8, and 1. Due to a characteristic time window and spatial resolution of $\mu^+$SR, the obtained phase diagram was found to be rather different from that determined by magnetization measurements. That is, as $x$ increases from 0, a Pauli-paramagnetic phase is observed even at the lowest $T$ measured (1.8~K) until $x=0.4$, then, a spin-glass like phase appears at $0.5\leq x\leq0.6$, and then, a phase with wide field distribution probably due to incommensurate AF order is detected for $x=0.8$, and finally, a commensurate $A$-type AF ordered phase (for $x=1$) is stabilized below $T_{\rm N}\sim80~$K. Such change is most likely reasonable and connected to the shrink of the $c$-axis length with $x$, which naturally enhances the magnetic interaction between the two adjacent Co planes., Comment: 5 pages, 5 figures, conference paper of muSR2014 (accepted for publication)
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- 2014
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30. Psychosocial Impact and Disease Management in Patients with Congenital Factor VII Deficiency
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Peltier S, Kellum A, Brewer J, Duncan A, Cooper DL, and Saad H
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bleeding disorder ,psychosocial impact ,recombinant activated factor vii ,survey ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Skye Peltier,1 Angela Kellum,2 Janet Brewer,3 Alexander Duncan,4 David L Cooper,5 Hossam Saad5 1Center for Bleeding and Clotting Disorders, University of Minnesota Medical Center - Fairview, Minneapolis, MN, USA; 2Louisiana Center for Bleeding and Clotting Disorders, Tulane University, New Orleans, LA, USA; 3Comprehensive Health Education Services, Hanson, MA, USA; 4Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; 5Novo Nordisk Inc., Plainsboro, NJ, USACorrespondence: Skye PeltierCenter for Bleeding and Clotting Disorders, University of Minnesota Medical Center – Fairview, Minneapolis, MN, USATel +1 612-273-5047Fax +1 612-273-5018Email speltie1@fairview.orgPurpose: Congenital factor VII (FVII) deficiency is a rare bleeding disorder of variable phenotype with predominantly mucocutaneous bleeding. The aim of this study was to identify the burden of FVII deficiency on patients and caregivers through a better understanding of the management and psychosocial impact of this disease.Materials and Methods: A rare disease specialty recruiter from Comprehensive Health Education Services recruited participants for this online survey, which was conducted from January 31 to March 12, 2019. A moderator-assisted questionnaire was used to collect data on demographics, diagnosis, treatment, and psychosocial impact.Results: Of the 45 respondents (25 patients and 20 caregivers), the majority were female (56%). Respondents reported a wide variety of initial bleeding symptoms, including bruising (58%), epistaxis (56%), and menorrhagia (36% of females). Because symptoms varied between individuals and were not always severe, diagnosis was often delayed. Mean time to obtain a diagnosis was 6.5 years and mean age at first diagnosis was 12.9 years. One-quarter (24%) of the respondents reported more than 100 bleeds of any severity over the previous year. When treating bleeds, 44% of patients reported using antifibrinolytics, and 42% reported using recombinant activated factor VII. Almost 31% of respondents reported missing schooldays as children, and 16% reported losing or resigning from a job in adulthood as a direct result of their disease. Notably, 29% of caregivers and 10% of their partners had also experienced issues with employment. Forty percent of respondents reported not participating in contact sports during childhood, and 22% continued to avoid contact sports in adulthood.Conclusion: Overall, FVII deficiency has a substantial psychosocial impact, but most patients are satisfied with their disease management and are optimistic about their future. Patients desire additional educational, social, and financial support.Keywords: bleeding disorder, psychosocial impact, recombinant activated factor VII, survey
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- 2020
31. The potential role of reproductive interference in the decline of native green treefrogs following Cuban treefrog invasions
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Kennedy, Joseph G. C., Johnson, Steve A., Brewer, J. Stephen, and Leary, Christopher J.
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- 2021
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32. Shrinking Magnetic Vortices in V3Si Due to Delocalized Quasiparticle Core States: Confirmation of the Microscopic Theory for Interacting Vortices
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Sonier, J. E., Callaghan, F. D., Miller, R. I., Boaknin, E., Taillefer, L., Kiefl, R. F., Brewer, J. H., Poon, K. F., and Brewer, J. D.
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Condensed Matter - Superconductivity - Abstract
We report muon spin rotation measurements on the conventional type-II superconductor V3Si that provide clear evidence for changes to the inner structure of a vortex due to the delocalization of bound quasiparticle core states. The experimental findings described here confirm a key prediction of recent microscopic theories describing interacting vortices. The effects of vortex-vortex interactions on the magnetic and electronic structure of the vortex state are of crucial importance to the interpretation of experiments on both conventional and exotic superconductors in an applied magnetic field., Comment: 5 pages, 3 figures. Some textual changes for increased clarity. Updated figure. Updated references
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- 2004
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33. Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
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Roulis, Manolis, Kaklamanos, Aimilios, Schernthanner, Marina, Bielecki, Piotr, Zhao, Jun, Kaffe, Eleanna, Frommelt, Laura-Sophie, Qu, Rihao, Knapp, Marlene S., Henriques, Ana, Chalkidi, Niki, Koliaraki, Vasiliki, Jiao, Jing, Brewer, J. Richard, Bacher, Maren, Blackburn, Holly N., Zhao, Xiaoyun, Breyer, Richard M., Aidinis, Vassilis, Jain, Dhanpat, Su, Bing, Herschman, Harvey R., Kluger, Yuval, Kollias, George, and Flavell, Richard A.
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- 2020
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34. Adapting the Law of Fish and Wildlife to the Science of Climate Change
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Brewer, J, Wandesforde-Smith, G, and Watts, NSJ
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climate change ,climate science ,fish and wildlife law ,Ecology ,Law - Published
- 2015
35. Longitudinal muon spin relaxation in high purity aluminum and silver
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Bueno, J. F., Arseneau, D. J., Bayes, R., Brewer, J. H., Faszer, W., Hasinoff, M. D., Marshall, G. M., Mathie, E. L., Mischke, R. E., Morris, G. D., Olchanski, K., Selivanov, V., and Tacik, R.
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Condensed Matter - Materials Science - Abstract
The time dependence of muon spin relaxation has been measured in high purity aluminum and silver samples in a longitudinal 2 T magnetic field at room temperature, using time-differential \musr. For times greater than 10 ns, the shape fits well to a single exponential with relaxation rates of $\lambda_{\textrm{Al}} = 1.3 \pm 0.2\,(\textrm{stat.}) \pm 0.3\,(\textrm{syst.})\,\pms$ and $\lambda_{\textrm{Ag}} = 1.0 \pm 0.2\,(\textrm{stat.}) \pm 0.2\,(\textrm{syst.})\,\pms$.
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- 2011
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36. Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment
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Tuena, C, Maestri, S, Serino, S, Pedroli, E, Stramba-Badiale, M, Riva, G, Silbert, L, Lind, B, Crissey, R, Kaye, J, Carter, R, Dolen, S, Quinn, J, Schneider, L, Pawluczyk, S, Becerra, M, Teodoro, L, Dagerman, K, Spann, B, Brewer, J, Fleisher, A, Vanderswag, H, Ziolkowski, J, Heidebrink, J, Zbizek-Nulph, L, Lord, J, Albers, C, Petersen, R, Mason, S, Knopman, D, Johnson, K, Villanueva-Meyer, J, Pavlik, V, Pacini, N, Lamb, A, Kass, J, Doody, R, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Mintz, A, Ances, B, Morris, J, Winkfield, D, Carroll, M, Stobbs-Cucchi, G, Oliver, A, Creech, M, Mintun, M, Schneider, S, Geldmacher, D, Love, M, Griffith, R, Clark, D, Brockington, J, Marson, D, Grossman, H, Goldstein, M, Greenberg, J, Mitsis, E, Shah, R, Lamar, M, Samuels, P, Duara, R, Greig-Custo, M, Rodriguez, R, Albert, M, Onyike, C, Farrington, L, Rudow, S, Brichko, R, Kielb, S, Smith, A, Raj, B, Fargher, K, Sadowski, M, Wisniewski, T, Shulman, M, Faustin, A, Rao, J, Castro, K, Ulysse, A, Chen, S, Doraiswamy, P, Petrella, J, James, O, Wong, T, Borges-Neto, S, Karlawish, J, Wolk, D, Vaishnavi, S, Clark, C, Arnold, S, Smith, C, Jicha, G, Khouli, R, Raslau, F, Lopez, O, Oakley, M, Simpson, D, Porsteinsson, A, Martin, K, Kowalski, N, Keltz, M, Goldstein, B, Makino, K, Ismail, M, Brand, C, Thai, G, Pierce, A, Yanez, B, Sosa, E, Witbracht, M, Kelley, B, Nguyen, T, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Hajjar, I, Burns, J, Swerdlow, R, Brooks, W, Silverman, D, Kremen, S, Apostolova, L, Tingus, K, Lu, P, Bartzokis, G, Woo, E, Teng, E, Graff-Radford, N, Parfitt, F, Poki-Walker, K, Farlow, M, Hake, A, Matthews, B, Brosch, J, Herring, S, van Dyck, C, Mecca, A, Good, S, Macavoy, M, Carson, R, Varma, P, Chertkow, H, Vaitekunas, S, Hosein, C, Black, S, Stefanovic, B, Heyn, C, Hsiung, G, Kim, E, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternak, S, Rachinsky, I, Kertesz, A, Drost, D, Rogers, J, Grant, I, Muse, B, Rogalski, E, Robson, J, Mesulam, M, Kerwin, D, Wu, C, Johnson, N, Lipowski, K, Weintraub, S, Bonakdarpour, B, Pomara, N, Hernando, R, Sarrael, A, Rosen, H, Miller, B, Weiner, M, Perry, D, Turner, R, Reynolds, B, Mccann, K, Poe, J, Marshall, G, Sperling, R, Yesavage, J, Taylor, J, Chao, S, Coleman, J, White, J, Lane, B, Rosen, A, Tinklenberg, J, Belden, C, Atri, A, Clark, K, Zamrini, E, Sabbagh, M, Killiany, R, Stern, R, Mez, J, Kowall, N, Budson, A, Obisesan, T, Ntekim, O, Wolday, S, Khan, J, Nwulia, E, Nadarajah, S, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Bates, V, Capote, H, Rainka, M, Borrie, M, Lee, T, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Perrin, A, Burke, A, Scharre, D, Kataki, M, Tarawneh, R, Hart, D, Zimmerman, E, Celmins, D, Miller, D, Ponto, L, Smith, K, Koleva, H, Shim, H, Nam, K, Schultz, S, Williamson, J, Craft, S, Cleveland, J, Yang, M, Sink, K, Ott, B, Drake, J, Tremont, G, Daiello, L, Ritter, A, Bernick, C, Munic, D, O'Connelll, A, Mintzer, J, Wiliams, A, Masdeu, J, Shi, J, Garcia, A, Newhouse, P, Potkin, S, Salloway, S, Malloy, P, Correia, S, Kittur, S, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Relkin, N, Chiang, G, Lee, A, Lin, M, Ravdin, L, Tuena C., Maestri S., Serino S., Pedroli E., Stramba-Badiale M., Riva G., Silbert L. C., Lind B., Crissey R., Kaye J. A., Carter R., Dolen S., Quinn J., Schneider L. S., Pawluczyk S., Becerra M., Teodoro L., Dagerman K., Spann B. M., Brewer J., Fleisher A., Vanderswag H., Ziolkowski J., Heidebrink J. L., Zbizek-Nulph L., Lord J. L., Albers C. S., Petersen R., Mason S. S., Knopman D., Johnson K., Villanueva-Meyer J., Pavlik V., Pacini N., Lamb A., Kass J. S., Doody R. S., Shibley V., Chowdhury M., Rountree S., Dang M., Stern Y., Honig L. S., Mintz A., Ances B., Morris J. C., Winkfield D., Carroll M., Stobbs-Cucchi G., Oliver A., Creech M. L., Mintun M. A., Schneider S., Geldmacher D., Love M. N., Griffith R., Clark D., Brockington J., Marson D., Grossman H., Goldstein M. A., Greenberg J., Mitsis E., Shah R. C., Lamar M., Samuels P., Duara R., Greig-Custo M. T., Rodriguez R., Albert M., Onyike C., Farrington L., Rudow S., Brichko R., Kielb S., Smith A., Raj B. A., Fargher K., Sadowski M., Wisniewski T., Shulman M., Faustin A., Rao J., Castro K. M., Ulysse A., Chen S., Doraiswamy P. M., Petrella J. R., James O., Wong T. Z., Borges-Neto S., Karlawish J. H., Wolk D. A., Vaishnavi S., Clark C. M., Arnold S. E., Smith C. D., Jicha G. A., Khouli R. E., Raslau F. D., Lopez O. L., Oakley M. A., Simpson D. M., Porsteinsson A. P., Martin K., Kowalski N., Keltz M., Goldstein B. S., Makino K. M., Ismail M. S., Brand C., Thai G., Pierce A., Yanez B., Sosa E., Witbracht M., Kelley B., Nguyen T., Womack K., Mathews D., Quiceno M., Levey A. I., Lah J. J., Hajjar I., Burns J. M., Swerdlow R. H., Brooks W. M., Silverman D. H. S., Kremen S., Apostolova L., Tingus K., Lu P. H., Bartzokis G., Woo E., Teng E., Graff-Radford N. R., Parfitt F., Poki-Walker K., Farlow M. R., Hake A. M., Matthews B. R., Brosch J. R., Herring S., van Dyck C. H., Mecca A. P., Good S. P., MacAvoy M. G., Carson R. E., Varma P., Chertkow H., Vaitekunas S., Hosein C., Black S., Stefanovic B., Heyn C., Hsiung G. -Y. R., Kim E., Mudge B., Sossi V., Feldman H., Assaly M., Finger E., Pasternak S., Rachinsky I., Kertesz A., Drost D., Rogers J., Grant I., Muse B., Rogalski E., Robson J., Mesulam M. -M., Kerwin D., Wu C. -K., Johnson N., Lipowski K., Weintraub S., Bonakdarpour B., Pomara N., Hernando R., Sarrael A., Rosen H. J., Miller B. L., Weiner M. W., Perry D., Turner R. S., Reynolds B., MCCann K., Poe J., Marshall G. A., Sperling R. A., Johnson K. A., Yesavage J., Taylor J. L., Chao S., Coleman J., White J. D., Lane B., Rosen A., Tinklenberg J., Belden C. M., Atri A., Clark K. A., Zamrini E., Sabbagh M., Killiany R., Stern R., Mez J., Kowall N., Budson A. E., Obisesan T. O., Ntekim O. E., Wolday S., Khan J. I., Nwulia E., Nadarajah S., Lerner A., Ogrocki P., Tatsuoka C., Fatica P., Fletcher E., Maillard P., Olichney J., DeCarli C., Carmichael O., Bates V., Capote H., Rainka M., Borrie M., Lee T. -Y., Bartha R., Johnson S., Asthana S., Carlsson C. M., Perrin A., Burke A., Scharre D. W., Kataki M., Tarawneh R., Hart D., Zimmerman E. A., Celmins D., Miller D. D., Ponto L. L. B., Smith K. E., Koleva H., Shim H., Nam K. W., Schultz S. K., Williamson J. D., Craft S., Cleveland J., Yang M., Sink K. M., Ott B. R., Drake J., Tremont G., Daiello L. A., Drake J. D., Ritter A., Bernick C., Munic D., O'Connelll A., Mintzer J., Wiliams A., Masdeu J., Shi J., Garcia A., Newhouse P., Potkin S., Salloway S., Malloy P., Correia S., Kittur S., Pearlson G. D., Blank K., Anderson K., Flashman L. A., Seltzer M., Hynes M. L., Santulli R. B., Relkin N., Chiang G., Lee A., Lin M., Ravdin L., Tuena, C, Maestri, S, Serino, S, Pedroli, E, Stramba-Badiale, M, Riva, G, Silbert, L, Lind, B, Crissey, R, Kaye, J, Carter, R, Dolen, S, Quinn, J, Schneider, L, Pawluczyk, S, Becerra, M, Teodoro, L, Dagerman, K, Spann, B, Brewer, J, Fleisher, A, Vanderswag, H, Ziolkowski, J, Heidebrink, J, Zbizek-Nulph, L, Lord, J, Albers, C, Petersen, R, Mason, S, Knopman, D, Johnson, K, Villanueva-Meyer, J, Pavlik, V, Pacini, N, Lamb, A, Kass, J, Doody, R, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Mintz, A, Ances, B, Morris, J, Winkfield, D, Carroll, M, Stobbs-Cucchi, G, Oliver, A, Creech, M, Mintun, M, Schneider, S, Geldmacher, D, Love, M, Griffith, R, Clark, D, Brockington, J, Marson, D, Grossman, H, Goldstein, M, Greenberg, J, Mitsis, E, Shah, R, Lamar, M, Samuels, P, Duara, R, Greig-Custo, M, Rodriguez, R, Albert, M, Onyike, C, Farrington, L, Rudow, S, Brichko, R, Kielb, S, Smith, A, Raj, B, Fargher, K, Sadowski, M, Wisniewski, T, Shulman, M, Faustin, A, Rao, J, Castro, K, Ulysse, A, Chen, S, Doraiswamy, P, Petrella, J, James, O, Wong, T, Borges-Neto, S, Karlawish, J, Wolk, D, Vaishnavi, S, Clark, C, Arnold, S, Smith, C, Jicha, G, Khouli, R, Raslau, F, Lopez, O, Oakley, M, Simpson, D, Porsteinsson, A, Martin, K, Kowalski, N, Keltz, M, Goldstein, B, Makino, K, Ismail, M, Brand, C, Thai, G, Pierce, A, Yanez, B, Sosa, E, Witbracht, M, Kelley, B, Nguyen, T, Womack, K, Mathews, D, Quiceno, M, Levey, A, Lah, J, Hajjar, I, Burns, J, Swerdlow, R, Brooks, W, Silverman, D, Kremen, S, Apostolova, L, Tingus, K, Lu, P, Bartzokis, G, Woo, E, Teng, E, Graff-Radford, N, Parfitt, F, Poki-Walker, K, Farlow, M, Hake, A, Matthews, B, Brosch, J, Herring, S, van Dyck, C, Mecca, A, Good, S, Macavoy, M, Carson, R, Varma, P, Chertkow, H, Vaitekunas, S, Hosein, C, Black, S, Stefanovic, B, Heyn, C, Hsiung, G, Kim, E, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternak, S, Rachinsky, I, Kertesz, A, Drost, D, Rogers, J, Grant, I, Muse, B, Rogalski, E, Robson, J, Mesulam, M, Kerwin, D, Wu, C, Johnson, N, Lipowski, K, Weintraub, S, Bonakdarpour, B, Pomara, N, Hernando, R, Sarrael, A, Rosen, H, Miller, B, Weiner, M, Perry, D, Turner, R, Reynolds, B, Mccann, K, Poe, J, Marshall, G, Sperling, R, Yesavage, J, Taylor, J, Chao, S, Coleman, J, White, J, Lane, B, Rosen, A, Tinklenberg, J, Belden, C, Atri, A, Clark, K, Zamrini, E, Sabbagh, M, Killiany, R, Stern, R, Mez, J, Kowall, N, Budson, A, Obisesan, T, Ntekim, O, Wolday, S, Khan, J, Nwulia, E, Nadarajah, S, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Bates, V, Capote, H, Rainka, M, Borrie, M, Lee, T, Bartha, R, Johnson, S, Asthana, S, Carlsson, C, Perrin, A, Burke, A, Scharre, D, Kataki, M, Tarawneh, R, Hart, D, Zimmerman, E, Celmins, D, Miller, D, Ponto, L, Smith, K, Koleva, H, Shim, H, Nam, K, Schultz, S, Williamson, J, Craft, S, Cleveland, J, Yang, M, Sink, K, Ott, B, Drake, J, Tremont, G, Daiello, L, Ritter, A, Bernick, C, Munic, D, O'Connelll, A, Mintzer, J, Wiliams, A, Masdeu, J, Shi, J, Garcia, A, Newhouse, P, Potkin, S, Salloway, S, Malloy, P, Correia, S, Kittur, S, Pearlson, G, Blank, K, Anderson, K, Flashman, L, Seltzer, M, Hynes, M, Santulli, R, Relkin, N, Chiang, G, Lee, A, Lin, M, Ravdin, L, Tuena C., Maestri S., Serino S., Pedroli E., Stramba-Badiale M., Riva G., Silbert L. C., Lind B., Crissey R., Kaye J. A., Carter R., Dolen S., Quinn J., Schneider L. S., Pawluczyk S., Becerra M., Teodoro L., Dagerman K., Spann B. M., Brewer J., Fleisher A., Vanderswag H., Ziolkowski J., Heidebrink J. L., Zbizek-Nulph L., Lord J. L., Albers C. S., Petersen R., Mason S. S., Knopman D., Johnson K., Villanueva-Meyer J., Pavlik V., Pacini N., Lamb A., Kass J. S., Doody R. S., Shibley V., Chowdhury M., Rountree S., Dang M., Stern Y., Honig L. S., Mintz A., Ances B., Morris J. C., Winkfield D., Carroll M., Stobbs-Cucchi G., Oliver A., Creech M. L., Mintun M. A., Schneider S., Geldmacher D., Love M. N., Griffith R., Clark D., Brockington J., Marson D., Grossman H., Goldstein M. A., Greenberg J., Mitsis E., Shah R. C., Lamar M., Samuels P., Duara R., Greig-Custo M. T., Rodriguez R., Albert M., Onyike C., Farrington L., Rudow S., Brichko R., Kielb S., Smith A., Raj B. A., Fargher K., Sadowski M., Wisniewski T., Shulman M., Faustin A., Rao J., Castro K. M., Ulysse A., Chen S., Doraiswamy P. M., Petrella J. R., James O., Wong T. Z., Borges-Neto S., Karlawish J. H., Wolk D. A., Vaishnavi S., Clark C. M., Arnold S. E., Smith C. D., Jicha G. A., Khouli R. E., Raslau F. D., Lopez O. L., Oakley M. A., Simpson D. M., Porsteinsson A. P., Martin K., Kowalski N., Keltz M., Goldstein B. S., Makino K. M., Ismail M. S., Brand C., Thai G., Pierce A., Yanez B., Sosa E., Witbracht M., Kelley B., Nguyen T., Womack K., Mathews D., Quiceno M., Levey A. I., Lah J. J., Hajjar I., Burns J. M., Swerdlow R. H., Brooks W. M., Silverman D. H. S., Kremen S., Apostolova L., Tingus K., Lu P. H., Bartzokis G., Woo E., Teng E., Graff-Radford N. R., Parfitt F., Poki-Walker K., Farlow M. R., Hake A. M., Matthews B. R., Brosch J. R., Herring S., van Dyck C. H., Mecca A. P., Good S. P., MacAvoy M. G., Carson R. E., Varma P., Chertkow H., Vaitekunas S., Hosein C., Black S., Stefanovic B., Heyn C., Hsiung G. -Y. R., Kim E., Mudge B., Sossi V., Feldman H., Assaly M., Finger E., Pasternak S., Rachinsky I., Kertesz A., Drost D., Rogers J., Grant I., Muse B., Rogalski E., Robson J., Mesulam M. -M., Kerwin D., Wu C. -K., Johnson N., Lipowski K., Weintraub S., Bonakdarpour B., Pomara N., Hernando R., Sarrael A., Rosen H. J., Miller B. L., Weiner M. W., Perry D., Turner R. S., Reynolds B., MCCann K., Poe J., Marshall G. A., Sperling R. A., Johnson K. A., Yesavage J., Taylor J. L., Chao S., Coleman J., White J. D., Lane B., Rosen A., Tinklenberg J., Belden C. M., Atri A., Clark K. A., Zamrini E., Sabbagh M., Killiany R., Stern R., Mez J., Kowall N., Budson A. E., Obisesan T. O., Ntekim O. E., Wolday S., Khan J. I., Nwulia E., Nadarajah S., Lerner A., Ogrocki P., Tatsuoka C., Fatica P., Fletcher E., Maillard P., Olichney J., DeCarli C., Carmichael O., Bates V., Capote H., Rainka M., Borrie M., Lee T. -Y., Bartha R., Johnson S., Asthana S., Carlsson C. M., Perrin A., Burke A., Scharre D. W., Kataki M., Tarawneh R., Hart D., Zimmerman E. A., Celmins D., Miller D. D., Ponto L. L. B., Smith K. E., Koleva H., Shim H., Nam K. W., Schultz S. K., Williamson J. D., Craft S., Cleveland J., Yang M., Sink K. M., Ott B. R., Drake J., Tremont G., Daiello L. A., Drake J. D., Ritter A., Bernick C., Munic D., O'Connelll A., Mintzer J., Wiliams A., Masdeu J., Shi J., Garcia A., Newhouse P., Potkin S., Salloway S., Malloy P., Correia S., Kittur S., Pearlson G. D., Blank K., Anderson K., Flashman L. A., Seltzer M., Hynes M. L., Santulli R. B., Relkin N., Chiang G., Lee A., Lin M., and Ravdin L.
- Abstract
Background: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer’s Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted to AD with those who remained with a stable aMCI diagnosis during the follow-up. Methods: Four hundred two individuals with aMCI from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database were included. Robust linear mixed-effects models were used to study the impact of gait abnormalities on a comprehensive neuropsychological battery over 36 months while controlling for relevant medical variables at baseline. The impact of gait on brain measures was also investigated. Lastly, the Cox proportional-hazards model was used to explore the prognostic relevance of abnormal gait and neuropsychological associated tests. Results: While controlling for relevant covariates, we found that gait abnormalities led to a greater decline over time in attention (DSST) and global cognition (MMSE). Intriguingly, psychomotor speed (TMT-A) and divided attention (TMT-B) declined uniquely in the abnormal gait group. Conversely, specific AD global cognition tests (ADAS-13) and auditory-verbal memory (RAVLT immediate recall) declined over time independently of gait profile. All the other cognitive tests were not significantly affected by time or by gait profile. In addition, we found that ventricles size increased faster in the abnormal gait group compared to the normal gait group. In terms of prognosis, abno
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- 2023
37. A Holy Vine and Scattered Bread: Realized Eschatology in Didache 9.2, 4
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Brewer, J Brittain, primary
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- 2024
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38. AMBRA1 is a predictive biomarker of melanoma response to targeted therapy
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Di Leo, L., primary, Pagliuca, C., additional, Kishk, A., additional, Rizza, S., additional, Tsiavou, C., additional, Pecorari, C., additional, Dahl, C., additional, Pacheco, M., additional, Tholstrup, R., additional, Brewer, J., additional, Berico, P., additional, Hernando, E., additional, Cecconi, F., additional, Ballotti, R., additional, Bertolotto, C., additional, Filomeni, G., additional, Gjerstorff, M., additional, Sauter, T., additional, Lovat, P., additional, Guldberg, P., additional, and De Zio, D., additional
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- 2024
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39. Inter- and intraspecific competition and shade avoidance in the carnivorous pale pitcher plant in a nutrient-poor savanna
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Brewer, J. Stephen
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- 2019
40. Naturally diverse plant communities do not resist invasion by the strong competitor, Microstegium vimineum.
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Williams, Griffin Lee and Brewer, J. Stephen
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PLANT species diversity , *PLANT communities , *BIOTIC communities , *PLANT invasions , *ENDANGERED species , *SPECIES diversity , *PLANT diversity - Abstract
Premise: Theory predicts and empirical studies have shown that ecologically manipulated communities with high species diversity are resistant to invasion, but do these predictions and results hold true when applied to highly competitive invaders in natural communities? Few studies of diversity‐mediated invasion resistance have measured both invasion resistance and invader impact in the same study. Methods: We used a two‐year field experiment to test: (1) diversity‐mediated competitive resistance to patch expansion by the grass, Microstegium vimineum; and (2) the competitive effect of M. vimineum on resident plant diversity. We examined responses of M. vimineum to two native plant density‐reduction treatments that had opposite effects on species diversity: (1) reducing species richness via the removal of rare species; and (2) reducing dominance by reducing the density of the dominant resident species. We examined the effects of M. vimineum reduction by pre‐emergent herbicide on resident diversity in the second year of the study. Results: Neither rare species removal nor dominant species reduction significantly increased M. vimineum density (relative growth rate). The pre‐emergent herbicide dramatically reduced M. vimineum in year 2 of the study, but not most resident plants, which were perennials and indirectly benefited from the herbicide at a more productive site, presumably due to reduced competition from M. vimineum. Conclusions: Diversity‐mediated resistance did not effectively deter invasion by a highly competitive invader. In the case of M. vimineum and at more productive sites, it would appear that nearly complete removal of this invader is necessary to preserve plant species diversity. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Aboveground versus soil‐mediated effects of an invasive grass on fire‐dependent forbs in an oak woodland.
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Williams, G. L. and Stephen Brewer, J.
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NATIVE species , *RESOURCE availability (Ecology) , *PLANT competition , *RESTORATION ecology , *INTRODUCED species , *CHEATGRASS brome - Abstract
Most work on plant competition intensity in general has focused on how aboveground and belowground competition for resources between plants changes with soil resource availability. In contrast, much work on the competitive effects of non‐native invasive species on native species has focused on other mechanisms (e.g., allelopathy and microbial changes) and has largely ignored how these effects interact with mechanisms of resource competition along productivity gradients. We examined aboveground effects of an invasive grass, Microstegium vimineum, along with soil differences between invaded and non‐invaded areas on two native perennial herbs at a productive and an unproductive oak woodland site in north Mississippi, USA. We transplanted 32 individuals each of Helianthus silphioides and Potentilla simplex from uninvaded areas into natural patches dominated by M. vimineum at each of the sites. Each transplant was randomly assigned to a pot with either native soil or soil from around M. vimineum roots. Aboveground competition was manipulated by securing M. vimineum shoots in a non‐shading position around the transplant. We monitored survival of all transplants weekly in the growing seasons of 2020 and 2021. Transplant survival of H. silphioides was lowest in M. vimineum soil at the more productive site when M. vimineum was not pinned back. Transplant survival of P. simplex was lower at the more productive site but was mostly unresponsive to pinning and soil treatments. Synthesis. Our results suggest that soil‐mediated legacy effects of an invader may reduce some native species' ability to compete for light at productive sites. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Fire Ecology and Fire Management of Southeastern Coastal Plain Pine Ecosystems
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Glitzenstein, Jeff S., primary, Brewer, J. Stephen, additional, Masters, Ronald E., additional, Varner, J. Morgan, additional, and Hiers, J. Kevin, additional
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- 2021
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43. Extracorporeal membrane oxygenation in diabetic ketoacidosis-related cardiac and respiratory failure
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Sharif, Ammar, primary, Brewer, J Michael, additional, El Banayosy, Aly, additional, Mihu, Mircea R, additional, Reaves, Zachary, additional, Swant, Laura V, additional, Schoaps, Robert S, additional, Benson, Clayne, additional, Khalid, Malik Ibithaj, additional, and Maybauer, Marc O, additional
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- 2023
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44. The binary fraction in the globular cluster NGC 6397
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Davis, D. S., Richer, H. B., Anderson, J., Brewer, J. P., Hurley, J., Kalirai, J. S., Rich, R. M., and Stetson, P. B.
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Astrophysics - Abstract
Using Hubble Space Telescope (HST) observations of the globular cluster NGC6397, we constrain the cluster's binary fraction. The observations consist of two fields: the primary science field, a single ACS pointing centered approximately 5' from the cluster center; and the parallel field, a single WFPC2 field centered on the cluster center. Using the exquisite photometric precision of these observations, we determine the binary fraction in these regions of the cluster by examining stars lying off the main sequence. The binary fraction is constrained to be 0.012 +/- 0.004 in the ACS field, and to be 0.051 +/- 0.010 in the WFPC field. N-body simulations by Hurley et al. (2007) suggest that the binary fraction remains nearly constant beyond the half-mass radius for the lifetime of the cluster. In the context of these simulations, our results suggest that NGC 6397 had a primordial binary fraction of only ~1%., Comment: 19 pages, 7 figures, accepted in AJ
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- 2008
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45. Spin-glass state of vortices in YBa2Cu3Oy and La2-xSrxCuO4 below the metal-to-insulator crossover
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Sonier, J. E., Callaghan, F. D., Ando, Y., Kiefl, R. F., Brewer, J. H., Kaiser, C. V., Pacradouni, V., Sabok-Sayr, S. A., Sun, X. F., Komiya, S., Hardy, W. N., Bonn, D. A., and Liang, R.
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Condensed Matter - Superconductivity - Abstract
Highly disordered magnetism confined to individual weakly interacting vortices is detected by muon spin rotation in two different families of high-transition-temperature superconductors, but only in samples on the low-doping side of the low-temperature normal state metal-to-insulator crossover (MIC). The results support an extended quantum phase transition (QPT) theory of competing magnetic and superconducting orders that incorporates the coupling between CuO2 planes. Contrary to what has been inferred from previous experiments, the static magnetism that coexists with superconductivity near the field-induced QPT is not ordered. Our findings unravel the mystery of the MIC and establish that the normal state of high-temperature superconductors is ubiquitously governed by a magnetic quantum critical point in the superconducting phase., Comment: 9 pages, 9 figures
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- 2007
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46. Hole doping dependences of the magnetic penetration depth and vortex core size in YBa2Cu3Oy: Evidence for stripe correlations near 1/8 hole doping
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Sonier, J. E., Sabok-Sayr, S. A., Callaghan, F. D., Kaiser, C. V., Pacradouni, V., Brewer, J. H., Stubbs, S. L., Hardy, W. N., Bonn, D. A., Liang, R., and Atkinson, W. A.
- Subjects
Condensed Matter - Superconductivity - Abstract
We report on muon spin rotation measurements of the internal magnetic field distribution n(B) in the vortex solid phase of YBa2Cu3Oy (YBCO) single crystals, from which we have simultaneously determined the hole doping dependences of the in-plane Ginzburg-Landau (GL) length scales in the underdoped regime. We find that Tc has a sublinear dependence on 1/lambda_{ab}^2, where lambda_{ab} is the in-plane magnetic penetration depth in the extrapolated limits T -> 0 and H -> 0. The power coefficient of the sublinear dependence is close to that determined in severely underdoped YBCO thin films, indicating that the same relationship between Tc and the superfluid density is maintained throughout the underdoped regime. The in-plane GL coherence length (vortex core size) is found to increase with decreasing hole doping concentration, and exhibit a field dependence that is explained by proximity-induced superconductivity on the CuO chains. Both the magnetic penetration depth and the vortex core size are enhanced near 1/8 hole doping, supporting the belief by some that stripe correlations are a universal property of high-Tc cuprates., Comment: 12 pages, 13 figures
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- 2007
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47. Avoided Quantum Criticality in YBa_2Cu_3O_y and La_{2-x}Sr_xCuO_4
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Sonier, J. E., Callaghan, F. D., Ando, Y., Kiefl, R. F., Brewer, J. H., Kaiser, C. V., Pacradouni, V., Sabok-Sayr, S. -A., Sun, X. F., Komiya, S., Hardy, W. N., Bonn, D. A., and Liang, R.
- Subjects
Condensed Matter - Superconductivity - Abstract
Spin-glass magnetism confined to individual weakly interacting vortices is detected in two different families of high-transition-temperature (T_c) superconductors, but only in samples on the low-doping side of the low-temperature normal state metal-to-insulator crossover (MIC). Our findings unravel the mystery of the MIC, but more importantly identify the true location of the field-induced quantum phase transition (QPT) in the superconducting state. The non-uniform appearance of magnetism in the vortex state favours a surprisingly exotic phase diagram, in which spatially inhomogeneous competing order is stabilized at the QPT, and an `avoided' quantum critical point (QCP) is realized at zero magnetic field., Comment: 4 pages, 3 figures, submitted to PRL
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- 2006
48. Incommensurate magnetic order in Ag$_{2}$NiO$_{2}$
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Sugiyama, J., Ikedo, Y., Mukai, K., Brewer, J. H., Ansaldo, E. J., Morris, G. D., Chow, K. H., Yoshida, H., and Hiroi, Z.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
The nature of the magnetic transition of the half-filled triangular antiferromagnet Ag$_{2}$NiO$_2$ with $T_{\rm N}$=56K was studied with positive muon-spin-rotation and relaxation ($\mu^+$SR) spectroscopy. Zero field $\mu^+$SR measurements indicate the existence of a static internal magnetic field at temperatures below $T_{\rm N}$. Two components with slightly different precession frequencies and wide internal-field distributions suggest the formation of an incommensurate antiferromagnetic order below 56 K. This implies that the antifrerromagnetic interaction is predominant in the NiO$_2$ plane in contrast to the case of the related compound NaNiO$_2$. An additional transition was found at $\sim$22 K by both $\mu^+$SR and susceptibility measurements. It was also clarified that the transition at $\sim$260 K observed in the susceptibility of Ag$_{2}$NiO$_{2}$ is induced by a purely structural transition., Comment: 6 pages, 6 figures, Phys. Rev. B 74, in press
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- 2006
49. Static magnetic order in metallic K$_{0.49}$CoO$_{2}$
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Sugiyama, J., Nozaki, H., Ikedo, Y., Mukai, K., Brewer, J. H., Ansaldo, E. J., Morris, G. D., Andreica, D., Amato, A., Fujii, T., and Asamitsu, A.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
By means of muon spin spectroscopy, we have found that K$_{0.49}$CoO$_2$ crystals undergo successive magnetic transitions from a high-T paramagnetic state to a magnetic ordered state below 60 K and then to a second ordered state below 16 K, even though K_{0.49}CoO_2 is metallic at least down to 4 K. An isotropic magnetic behavior and wide internal-field distributions suggest the formation of a commensurate helical spin density wave (SDW) state below 16 K, while a linear SDW state is likely to exist above 16 K. It was also found that K_{0.49}CoO_2 exhibits a further transition at 150 K presumably due to a change in the spin state of the Co ions. Since the T dependence of the internal-field below 60 K was similar to that for Na_{0.5}CoO_2, this suggests that magnetic order is more strongly affected by the Co valence than by the interlayer distance/interaction and/or the charge-ordering., Comment: 4 pages, 5 figures, accepted for publication in Phys. Rev. Lett
- Published
- 2005
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50. Doping Dependence of the muSR Lineshape in YBa_{2}Cu_{3}O_{y} Crystals: Strong Evidence for y = 6.0 Antiferromagnetism in the Vortex Cores of y = 6.50
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Sonier, J. E., Callaghan, F. D., Brewer, J. H., Hardy, W. N., Bonn, D. A., and Liang, R.
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Condensed Matter - Superconductivity - Abstract
This paper has been withdrawn by the authors, because of results obtained from a more exhaustive study of both YBa_2Cu_3O_y and La_{2-x}Sr_xCuO_4 (see cond-mat/0610051)., Comment: This paper has been withdrawn
- Published
- 2005
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