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1. Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study.

Author

Esposito, Maria and Carotenuto, Marco

Subjects
*MIGRAINE in children, *GINKGO, *VITAMIN C, *DRUG efficacy, *UBIQUINONES, *NATUROPATHY, *PLATELET aggregation inhibitors, *SCHOOL children
Abstract

Primary headaches (migraines and tension-types headaches) are very common in school-aged children. Ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, was considered as a promising pharmacological aid for the treatment of migraine in adult patients because of its modulation of the glutamatergic transmission in the CNS and on antiplatelet activating factor (PAF). The aim of study is to verify the effectiveness and safety of association of Ginkgolide B/Coenzyme Q10/Riboflavin/Magnesium complex for brief prophylaxis in a population of school-aged children with migraine. In our sample after 3 months of treatment with association of Ginkgolide B/CoenzymeQ10/Riboflavin/Magnesium complex, the mean frequency per month of migraine was significantly decreased (9.71 ± 4.33 vs. 4.53 ± 3.96 attacks; p < 0.001). Our findings suggest that in childhood headache management, the use of alternative treatments must be considered not to evoke a placebo effect, but as soft therapy without adverse reactions. [ABSTRACT FROM AUTHOR]

Published
2011
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2. Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: An open-label study

Author

Marco Carotenuto, Maria Esposito, Esposito, Maria, and Carotenuto, Marco

Subjects
Male, medicine.medical_specialty, Ubiquinone, Migraine Disorders, Riboflavin, Population, Brief prophylaxis, Dermatology, Pharmacology, Natural therapy, Placebo, Brief prophylaxi, chemistry.chemical_compound, Lactones, Pharmacotherapy, Migraine Disorder, Internal medicine, Childhood migraine, Ginkgolide, medicine, Humans, Magnesium, education, Child, Vitaminic complexe, Coenzyme Q10, education.field_of_study, Analysis of Variance, business.industry, General Medicine, Lactone, medicine.disease, Clinical trial, Ginkgolides, chemistry, Migraine, Psychiatry and Mental Health, Drug Therapy, Combination, Female, Neurology (clinical), Headaches, medicine.symptom, business, Vitaminic complexes, Human
Abstract

Primary headaches (migraines and tension-types headaches) are very common in school-aged children. Ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, was considered as a promising pharmacological aid for the treatment of migraine in adult patients because of its modulation of the glutamatergic transmission in the CNS and on antiplatelet activating factor (PAF). The aim of study is to verify the effectiveness and safety of association of Ginkgolide B/Coenzyme Q10/Riboflavin/Magnesium complex for brief prophylaxis in a population of school-aged children with migraine. In our sample after 3 months of treatment with association of Ginkgolide B/CoenzymeQ10/Riboflavin/ Magnesium complex, the mean frequency per month of migraine was significantly decreased (9.71 ± 4.33 vs. 4.53 ± 3.96 attacks; p < 0.001). Our findings suggest that in childhood headache management, the use of alternative treatments must be considered not to evoke a placebo effect, but as soft therapy without adverse reactions. © 2010 Springer-Verlag.

Published
2011

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