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16 results on '"Brielle, Esther"'

1. Medieval DNA from Soqotra points to Eurasian origins of an isolated population at the crossroads of Africa and Arabia

Author

Sirak, Kendra, Jansen Van Rensburg, Julian, Brielle, Esther, Chen, Bowen, Lazaridis, Iosif, Ringbauer, Harald, Mah, Matthew, Mallick, Swapan, Micco, Adam, Rohland, Nadin, Callan, Kimberly, Curtis, Elizabeth, Kearns, Aisling, Lawson, Ann Marie, Workman, J. Noah, Zalzala, Fatma, Ahmed Al-Orqbi, Ahmed Saeed, Ahmed Salem, Esmail Mohammed, Salem Hasan, Ali Mohammed, Britton, Daniel Charles, and Reich, David

Published
2024
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2. Entwined African and Asian genetic roots of medieval peoples of the Swahili coast

Author

Brielle, Esther S., Fleisher, Jeffrey, Wynne-Jones, Stephanie, Sirak, Kendra, Broomandkhoshbacht, Nasreen, Callan, Kim, Curtis, Elizabeth, Iliev, Lora, Lawson, Ann Marie, Oppenheimer, Jonas, Qiu, Lijun, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Ayodo, George, Gidna, Agness O., Kabiru, Angela, Kwekason, Amandus, Mabulla, Audax Z. P., Manthi, Fredrick K., Ndiema, Emmanuel, Ogola, Christine, Sawchuk, Elizabeth, Al-Gazali, Lihadh, Ali, Bassam R., Ben-Salem, Salma, Letellier, Thierry, Pierron, Denis, Radimilahy, Chantal, Rakotoarisoa, Jean-Aimé, Raaum, Ryan L., Culleton, Brendan J., Mallick, Swapan, Rohland, Nadin, Patterson, Nick, Mwenje, Mohammed Ali, Ahmed, Khalfan Bini, Mohamed, Mohamed Mchulla, Williams, Sloan R., Monge, Janet, Kusimba, Sibel, Prendergast, Mary E., Reich, David, and Kusimba, Chapurukha M.

Published
2023
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5. Hydrogen Bond Strengthens Acceptor Group: The Curious Case of the C–H···O=C Bond.

Author

Basu, Kingshuk, Brielle, Esther S., and Arkin, Isaiah T.

Subjects
*MOLECULAR spectroscopy, *FOURIER transform infrared spectroscopy, *BIOMACROMOLECULES, *DENSITY functional theory, *HYDROGEN atom
Abstract

An H-bond involves the sharing of a hydrogen atom between an electronegative atom to which it is covalently bound (the donor) and another electronegative atom serving as an acceptor. Such bonds represent a critically important geometrical force in biological macromolecules and, as such, have been characterized extensively. H-bond formation invariably leads to a weakening within the acceptor moiety due to the pulling exerted by the donor hydrogen. This phenomenon can be compared to a spring connecting two masses; pulling one mass stretches the spring, similarly affecting the bond between the two masses. Herein, we describe the opposite phenomenon when investigating the energetics of the C–H···O=C bond. This bond underpins the most prevalent protein transmembrane dimerization motif (GxxxG) in which a glycine Cα-H on one helix forms a hydrogen bond with a carbonyl in a nearby helix. We use isotope-edited FT-IR spectroscopy and corroborating computational approaches to demonstrate a surprising strengthening of the acceptor C=O bond upon binding with the glycine Cα-H. We show that electronic factors associated with the Cα-H bond strengthen the C=O oscillator by increasing the s-character of the σ-bond, lowering the hyperconjugative disruption of the π-bond. In addition, a reduction of the acceptor C=O bond's polarity is observed upon the formation of the C–H···O=C bond. Our findings challenge the conventional understanding of H-bond dynamics and provide new insights into the structural stability of inter-helical protein interactions. [ABSTRACT FROM AUTHOR]

Published
2024
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6. The Entwined African and Asian Genetic Roots of the Medieval Peoples of the Swahili Coast

Author

Brielle, Esther S, primary, Fleisher, Jeffrey, additional, Wynne-Jones, Stephanie, additional, Broomandskhoshbacht, Nasreen, additional, Callan, Kim, additional, Curtis, Elizabeth, additional, Iliev, Lora, additional, Lawson, Ann Marie, additional, Oppenheimer, Jonas, additional, Qiu, Lijun, additional, Stewardson, Kristin, additional, Workman, Noah, additional, Zalzala, Fatma, additional, Ayodo, George, additional, Gidna, Agness, additional, Kabiru, Angela, additional, Kwekason, Amandus, additional, Mabulla, Audax, additional, Manthi, Fredrick Kyalo, additional, Ndiema, Emmanuel, additional, Ogola, Christine, additional, Sawchuk, Elizabeth, additional, Al-Gazali, Lihadh, additional, Ali, Bassam R, additional, Ben-Salem, Salma, additional, Letellier, Thierry, additional, Pierron, Denis, additional, Radimilahy, Chantal, additional, Rakotoarisoa, Jean-Aime, additional, Culleton, Brendan, additional, Mallick, Swapan, additional, Rohland, Nadin, additional, Patterson, Nick, additional, Mwenje, Mohammed Ali, additional, Ahmed, Khalfan Bini, additional, Mohamed, Mohamed Mchulla, additional, Williams, Sloan, additional, Monge, Janet, additional, Kusimba, Sibel, additional, Prendergast, Mary, additional, Reich, David, additional, and Kusimba, Chapurukha, additional

Published
2022
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8. Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of Nsp1, Nsp2, and Nucleocapsid proteins from SARS-CoV-2

Author

Slavin, Moriya, primary, Zamel, Joanna, additional, Zohar, Keren, additional, Eliyahu, Siona, additional, Braitbard, Merav, additional, Brielle, Esther, additional, Baraz, Leah, additional, Stolovich-Rain, Miri, additional, Friedman, Ahuva, additional, Wolf, Dana G, additional, Rouvinski, Alexander, additional, Linial, Michal, additional, Schneidman-Duhovny, Dina, additional, and Kalisman, Nir, additional

Published
2021
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12. A molecular switch for Cdc48 activity and localization during oxidative stress and aging

Author

Radzinski, Meytal, primary, Yogev, Ohad, additional, Yesharim, Yarden, additional, Brielle, Esther S., additional, Israeli, Ran, additional, Fassler, Rosi, additional, Melamed-Book, Naomi, additional, Shai, Nadav, additional, Arkin, Isaiah T., additional, Pick, Elah, additional, Ravid, Tommer, additional, Schuldiner, Maya, additional, and Reichmann, Dana, additional

Published
2019
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15. De novo STXBP1mutation in a child with developmental delay and spasticity reveals a major structural alteration in the interface with syntaxin 1A

Author

Banne, Ehud, Falik‐Zaccai, Tzipora, Brielle, Esther, Kalfon, Limor, Ladany, Hagay, Klinger, Danielle, Schneidman‐Duhovny, Dina, and Linial, Michal

Abstract

STXBP1, also known as Munc‐18, is a master regulator of neurotransmitter release and synaptic function in the human brain through its direct interaction with syntaxin 1A. STXBP1 binds syntaxin 1A is an inactive conformational state. STXBP1 decreases its binding affinity to syntaxin upon phosphorylation, enabling syntaxin 1A to engage in the SNARE complex, leading to neurotransmitter release. STXBP1‐related disorders are well characterized by encephalopathy with epilepsy, and a diverse range of neurological and neurodevelopmental conditions. Through exome sequencing of a child with developmental delay, hypotonia, and spasticity, we found a novel de novo insertion mutation of three nucleotides in the STXBP1 coding region, resulting in an additional arginine after position 39 (R39dup). Inconclusive results from state‐of‐the‐art variant prediction tools mandated a structure‐based approach using molecular dynamics (MD) simulations of the STXBP1–syntaxin 1A complex. Comparison of the interaction interfaces of the wild‐type and the R39dup complexes revealed a reduced interaction surface area in the mutant, leading to destabilization of the protein complex. Moreover, the decrease in affinity toward syntaxin 1A is similar for the phosphorylated STXBP1 and the R39dup. We applied the same MD methodology to seven additional previously reported STXBP1 mutations and reveal that the stability of the STXBP1–syntaxin 1A interface correlates with the reported clinical phenotypes. This study provides a direct link between the outcome of a novel variant in STXBP1 and protein structure and dynamics. The structural change upon mutation drives an alteration in synaptic function.

Published
2020
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16. The Genetic Origin of the Indo-Europeans.

Author

Lazaridis I, Patterson N, Anthony D, Vyazov L, Fournier R, Ringbauer H, Olalde I, Khokhlov AA, Kitov EP, Shishlina NI, Ailincăi SC, Agapov DS, Agapov SA, Batieva E, Bauyrzhan B, Bereczki Z, Buzhilova A, Changmai P, Chizhevsky AA, Ciobanu I, Constantinescu M, Csányi M, Dani J, Dashkovskiy PK, Évinger S, Faifert A, Flegontov PN, Frînculeasa A, Frînculeasa MN, Hajdu T, Higham T, Jarosz P, Jelínek P, Khartanovich VI, Kirginekov EN, Kiss V, Kitova A, Kiyashko AV, Koledin J, Korolev A, Kosintsev P, Kulcsár G, Kuznetsov P, Magomedov R, Malikovich MA, Melis E, Moiseyev V, Molnár E, Monge J, Negrea O, Nikolaeva NA, Novak M, Ochir-Goryaeva M, Pálfi G, Popovici S, Rykun MP, Savenkova TM, Semibratov VP, Seregin NN, Šefčáková A, Serikovna MR, Shingiray I, Shirokov VN, Simalcsik A, Sirak K, Solodovnikov KN, Tárnoki J, Tishkin AA, Trifonov V, Vasilyev S, Akbari A, Brielle ES, Callan K, Candilio F, Cheronet O, Curtis E, Flegontova O, Iliev L, Kearns A, Keating D, Lawson AM, Mah M, Micco A, Michel M, Oppenheimer J, Qiu L, Noah Workman J, Zalzala F, Szécsényi-Nagy A, Palamara PF, Mallick S, Rohland N, Pinhasi R, and Reich D

Abstract

The Yamnaya archaeological complex appeared around 3300BCE across the steppes north of the Black and Caspian Seas, and by 3000BCE reached its maximal extent from Hungary in the west to Kazakhstan in the east. To localize the ancestral and geographical origins of the Yamnaya among the diverse Eneolithic people that preceded them, we studied ancient DNA data from 428 individuals of which 299 are reported for the first time, demonstrating three previously unknown Eneolithic genetic clines. First, a "Caucasus-Lower Volga" (CLV) Cline suffused with Caucasus hunter-gatherer (CHG) ancestry extended between a Caucasus Neolithic southern end in Neolithic Armenia, and a steppe northern end in Berezhnovka in the Lower Volga. Bidirectional gene flow across the CLV cline created admixed intermediate populations in both the north Caucasus, such as the Maikop people, and on the steppe, such as those at the site of Remontnoye north of the Manych depression. CLV people also helped form two major riverine clines by admixing with distinct groups of European hunter-gatherers. A "Volga Cline" was formed as Lower Volga people mixed with upriver populations that had more Eastern hunter-gatherer (EHG) ancestry, creating genetically hyper-variable populations as at Khvalynsk in the Middle Volga. A "Dnipro Cline" was formed as CLV people bearing both Caucasus Neolithic and Lower Volga ancestry moved west and acquired Ukraine Neolithic hunter-gatherer (UNHG) ancestry to establish the population of the Serednii Stih culture from which the direct ancestors of the Yamnaya themselves were formed around 4000BCE. This population grew rapidly after 3750-3350BCE, precipitating the expansion of people of the Yamnaya culture who totally displaced previous groups on the Volga and further east, while admixing with more sedentary groups in the west. CLV cline people with Lower Volga ancestry contributed four fifths of the ancestry of the Yamnaya, but also, entering Anatolia from the east, contributed at least a tenth of the ancestry of Bronze Age Central Anatolians, where the Hittite language, related to the Indo-European languages spread by the Yamnaya, was spoken. We thus propose that the final unity of the speakers of the "Proto-Indo-Anatolian" ancestral language of both Anatolian and Indo-European languages can be traced to CLV cline people sometime between 4400-4000 BCE., Competing Interests: Conflict of Interest Statement The authors declare no competing interests.

Published
2024
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