254 results on '"Brien, James D."'
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2. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization
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Karger, Amy B, Brien, James D, Christen, Jayne M, Dhakal, Santosh, Kemp, Troy J, Klein, Sabra L, Pinto, Ligia A, Premkumar, Lakshmanane, Roback, John D, Binder, Raquel A, Boehme, Karl W, Boppana, Suresh, Cordon-Cardo, Carlos, Crawford, James M, Daiss, John L, Dupuis, Alan P, Espino, Ana M, Firpo-Betancourt, Adolfo, Forconi, Catherine, Forrest, J Craig, Girardin, Roxie C, Granger, Douglas A, Granger, Steve W, Haddad, Natalie S, Heaney, Christopher D, Hunt, Danielle T, Kennedy, Joshua L, King, Christopher L, Krammer, Florian, Kruczynski, Kate, LaBaer, Joshua, Lee, F Eun-Hyung, Lee, William T, Liu, Shan-Lu, Lozanski, Gerard, Lucas, Todd, Mendu, Damodara Rao, Moormann, Ann M, Murugan, Vel, Okoye, Nkemakonam C, Pantoja, Petraleigh, Payne, Anne F, Park, Jin, Pinninti, Swetha, Pinto, Amelia K, Pisanic, Nora, Qiu, Ji, Sariol, Carlos A, Simon, Viviana, Song, Lusheng, Steffen, Tara L, Stone, E Taylor, Styer, Linda M, Suthar, Mehul S, Thomas, Stefani N, Thyagarajan, Bharat, Wajnberg, Ania, Yates, Jennifer L, and Sobhani, Kimia
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Clinical Research ,Cancer ,Emerging Infectious Diseases ,Good Health and Well Being ,Antibodies ,Viral ,COVID-19 ,COVID-19 Testing ,Humans ,SARS-CoV-2 ,Serologic Tests ,SeroNet ,assay harmonization ,serology ,Immunology ,Microbiology - Abstract
In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and "to develop, validate, improve, and implement serological testing and associated technologies" (https://www.cancer.gov/research/key-initiatives/covid-19/coronavirus-research-initiatives/serological-sciences-network). SeroNet is comprised of 25 participating research institutions partnering with the Frederick National Laboratory for Cancer Research (FNLCR) and the SeroNet Coordinating Center. Since its inception, SeroNet has supported collaborative development and sharing of COVID-19 serological assay procedures and has set forth plans for assay harmonization. To facilitate collaboration and procedure sharing, a detailed survey was sent to collate comprehensive assay details and performance metrics on COVID-19 serological assays within SeroNet. In addition, FNLCR established a protocol to calibrate SeroNet serological assays to reference standards, such as the U.S. severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology standard reference material and first WHO international standard (IS) for anti-SARS-CoV-2 immunoglobulin (20/136), to facilitate harmonization of assay reporting units and cross-comparison of study data. SeroNet institutions reported development of a total of 27 enzyme-linked immunosorbent assay (ELISA) methods, 13 multiplex assays, and 9 neutralization assays and use of 12 different commercial serological methods. FNLCR developed a standardized protocol for SeroNet institutions to calibrate these diverse serological assays to reference standards. In conclusion, SeroNet institutions have established a diverse array of COVID-19 serological assays to study the immune response to SARS-CoV-2 and vaccines. Calibration of SeroNet serological assays to harmonize results reporting will facilitate future pooled data analyses and study cross-comparisons. IMPORTANCE SeroNet institutions have developed or implemented 61 diverse COVID-19 serological assays and are collaboratively working to harmonize these assays using reference materials to establish standardized reporting units. This will facilitate clinical interpretation of serology results and cross-comparison of research data.
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- 2022
3. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials
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Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefévre, Guillaume, Gottenberg, Jacques-Eric, Hansmann, Yves, Blanc, Frédéric, Ohlmann-Caillard, Sophie, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurelien, Heger, Bob, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Mertes, Paul-Michel, Noll, Eric, Oberlin, Mathieu, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Weill, François, Meyer, Nicolas, Andres, Emmanuel, Demonsant, Eric, Tayebi, Hakim, Nisand, Gabriel, Brin, Stéphane, Sublon, Cédric, Becker, Guillaume, Hutt, Anne, Martin, Tristan, Bayer, Sophie, Metzger, Catherine, Mekinian, Arsene, Abisror, Noémie, Adedjouma, Amir, Bollens, Diane, Bonneton, Marion, Bourcicaux, Nathalie, Bourrier, Anne, Thibault Chiarabiani, Maria Chauchard, Chopin, Doroth.e, Cohen, Jonathan, Devred, Ines, Donadille, Bruno, Fain, Olivier, Hariri, Geoffrey, Jachiet, Vincent, Ingliz, Patrick, Garnier, Marc, Gatfosse, Marc, Ghrenassia, Etienne, Gobert, Delphine, Krause le Garrec, Jessica, Landman, Cecilia, Lavillegrand, Jean Remy, Lefebvre, Benedicte, Mahevas, Thibault, Mazerand, Sandie, Meynard, Jean Luc, Morgand, Marjolaine, Ouaz.ne, Zineb, Pacanowski, Jerome, Riviere, S.bastien, Seksik, Philippe, Sokol, Harry, Soliman, Heithem, Valin, Nadia, Urbina, Thomas, McAvoy, Chloé, Miranda, Maria Pereira, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Nguyen, Anne Daguenel, Girault, Elise, Mayala-Kanda, Cl.mentine, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Pennet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Val.rie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Rachline, Anne, Isernia, Valentina, Bao-chau, Phung, Vallois, Dorothée, Sautereau, Aurelie, Neukrich, Catherine, Dossier, Antoine, Borie, Raphaël, Crestani, Bruno, Ducrocq, Gregory, Steg, Philippe Gabriel, Dieude, Philippe, Papo, Thomas, Marcault, Estelle, Chaudhry, Marhaba, Da Silveira, Charléne, Metois, Annabelle, Mahenni, Ismahan, Meziani, Meriam, Nilusmas, Cyndie, Le Gac, Sylvie, Ndiaye, Awa, Louni, Fran.oise, Chansombat, Malikhone, Julia, Zelie, Chalal, Solaya, Chalal, Lynda, Kramer, Laura, Le Grand, Jeniffer, Ouifiya, Kafif, Piquard, Valentine, Tubiana, Sarah, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anais, Zarrouk, Virginie, de Lastours, Victoire, Uzzan, Matthieu, Gamany, Naura, Claveirole, Agathe, Navid, Alexandre, Fouque, Tiffanie, Cohen, Yonathan, Lupo, Maya, Gilles, Constance, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, de Castro, Nathalie, Clément, Melissa, Darmon, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lenglin, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asma, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Lebras, Karine Celli, Chabert, Julien, Djaghout, Lamia, Fauvaux, Catherine, Jegu, Anne Lise, Kozakiewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madelaine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, Sène, Damien, Burlacu, Ruxandra, Chousterman, Benjamin, Mégarbanne, Bruno, Richette, Pascal, Riveline, Jean-Pierre, Frazier, Aline, Vicaut, Eric, Berton, Laure, Hadjam, Tassadit, Vazquez-Ibarra, Miguel Alejandro, Jourdaine, Clément, Tran, Olivia, Jouis, Véronique, Jacob, Aude, Smati, Julie, Renaud, Stéphane, Pernin, Claire, Suarez, Lydia, Semerano, Luca, Abad, Sébastien, nainous, Ruben B., Bonnet, Nicolas, Comparon, Celine, Cohen, Yves, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Gille, Thomas, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Nunes, Hilario, Oziel, Johanna, Roulot, Dominique, Sese, Lucile, ClaireTantet, Uzunhan, Yurdagul, Bloch-Queyrat, Coralie, Levy, Vincent, Messani, Fadhila, Rahaoui, Mohammed, Petit, Myléne, Brahmi, Sabrina, Rathoin, Vanessa, Rigal, Marthe, Costedoat-Chalumeau, Nathalie, Luong, Liem Binh, Hamou, Zakaria Ait, Benghanem, Sarah, Blanche, Philippe, Carlier, Nicolas, Chaigne, Benjamin, Gauzit, Remy, Joumaa, Hassan, Jozwiak, Mathieu, Lachétre, Marie, Lafoeste, Hélène, Launay, Odie, Legendre, Paul, Marey, Jonathan, Morbieu, Caroline, Palmieri, Lola-Jade, Szwebel, Tali-Anne, Abdoul, Hendy, Bruneau, Alexandra, Beclin-Clabaux, Audrey, Larrieu, Charly, Montanari, Pierre, Dufour, Eric, Clarke, Ada, Le Bourlout, Catherine, Marin, Nathalie, Menage, Nathalie, Saleh-Mghir, Samira, Cisse, Mamadou Salif, Cheref, Kahina, Guerin, Corinne, Zerbit, Jérémie, Michel, Marc, Gallien, Sébastien, Crickx, Etienne, Le Vavasseur, Benjamin, Kempf, Emmanuelle, Jaffal, Karim, Vindrios, William, Oniszczuk, Julie, Guillaud, Constance, Lim, Pascal, Fois, Elena, Melica, Giovanna, Matignon, Marie, Jalabert, Maud, Lelièvre, Jean-Daniel, Schmitz, David, Bourhis, Marion, Belazouz, Sylia, Languille, Laetitia, Boucle, Caroline, Cita, Nelly, Didier, Agnés, Froura, Fahem, Ledudal, Katia, Sadaoui, Thiziri, Thiemele, Alaki, Le Febvre De Bailly, Delphine, Verlinde, Muriel Carvhalo, Mayaux, Julien, Cacoub, Patrice, Saadoun, David, Vautier, Mathieu, Bugaut, Héléne, Benveniste, Olivier, Allenbach, Yves, Leroux, Gaëlle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Chloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Goncalo, Ferfar, Yasmina, Corvol, Jean-Christophe, Louapre, C.line, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aicha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sebastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Charbonnier, Fanny, Aguilar, Claire, Alby-Laurent, Fanny, Burger, Carole, Campos-Vega, Clara, Chavarot, Nathalie, Fournier, Benjamin, Rouzaud, Claire, Vimpére, Damien, Elie, Caroline, Bakouboula, Prissile, Choupeaux, Laure, Granville, Sophie, Issorat, Elodie, Broissand, Christine, Alyanakian, Marie-Alexandra, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Héléne, Duclos-vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Kounis, Ilias, Tamazirt, Sonia, Rudant, Eric, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Christophe, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Netzer, Florence, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Héléne, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Chan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Marquis, Eric, Benoit, Philippe, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Helene, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, Ader, F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia
- Published
- 2024
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4. Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse.
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Brien, James D, Hassert, Mariah, Stone, E Taylor, Geerling, Elizabeth, Cruz-Orengo, Lillian, and Pinto, Amelia K
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Immunology and Infection ,Issue 150 ,Zika virus ,brain ,spinal cord ,kidney ,spleen ,liver ,viral titer ,focus forming assay ,quantitative real-time PCR ,foot pad infection ,Cognitive Sciences ,Biochemistry and Cell Biology ,Psychology - Abstract
The methods being presented demonstrate laboratory procedures for the isolation of organs from Zika virus infected animals and the quantification of viral load. The purpose of the procedure is to quantify viral titers in peripheral and CNS areas of the mouse at different time points post infection or under different experimental conditions to identify virologic and immunological factors that regulate Zika virus infection. The organ isolation procedures demonstrated allow for both focus forming assay quantification and quantitative PCR assessment of viral titers. The rapid organ isolation techniques are designed for the preservation of virus titer. Viral titer quantification by focus forming assay allows for the rapid throughput assessment of Zika virus. The benefit of the focus forming assay is the assessment of infectious virus, the limitation of this assay is the potential for organ toxicity reducing the limit of detection. Viral titer assessment is combined with quantitative PCR, and using a recombinant RNA copy control viral genome copy number within the organ is assessed with low limit of detection. Overall these techniques provide an accurate rapid high throughput method for the analysis of Zika viral titers in the periphery and CNS of Zika virus infected animals and can be applied to the assessment of viral titers in the organs of animals infected with most pathogens, including Dengue virus.
- Published
- 2019
5. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
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Wahid, Lana, Walter, Emmanuel B., Belur, Akhila G., Dreyer, Grace, Patterson, Jan E., Bowling, Jason E., Dixon, Danielle O., Hewlett, Angela, Odrobina, Robert, Pupaibool, Jakrapun, Mocherla, Satish, Lazarte, Suzana, Cayabyab, Meilani, Hussein, Rezhan H., Golamari, Reshma R., Krill, Kaleigh L., Rajme, Sandra, Riska, Paul F., Zingman, Barry S., Mertz, Gregory, Sosa, Nestor, Goepfert, Paul A., Berhe, Mezgebe, Dishner, Emma, Fayed, Mohamed, Hubel, Kinsley, Martinez-Orozco, José Arturo, Bautista Felix, Nora, Elmor, Sammy T., Bechnak, Amer Ryan, Saklawi, Youssef, Van Winkle, Jason W., Zea, Diego F., Laguio-Vila, Maryrose, Walsh, Edward E., Falsey, Ann R., Carvajal, Karen, Hyzy, Robert C., Hanna, Sinan, Olbrich, Norman, Traenkner, Jessica J., Kraft, Colleen S., Tebas, Pablo, Baron, Jillian T, Levine, Corri, Nock, Joy, Billings, Joanne, Kim, Hyun, Elie-Turenne, Marie-Carmelle, Whitaker, Jennifer A., Luetkemeyer, Anne F., Dwyer, Jay, Bainbridge, Emma, Gyun Choe, Pyoeng, Kyung Kang, Chang, Jilg, Nikolaus, Cantos, Valeria D, Bhamidipati, Divya R., Nithin Gopalsamy, Srinivasa, Chary, Aarthi, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Benson, Constance A., McConnell, Kimberly, Wang, Jennifer P., Wessolossky, Mireya, Perez, Katherine, Eubank, Taryn A, Berjohn, Catherine, Utz, Gregory C., Jackson, Patrick E.H., Bell, Taison D., Haughey, Heather M., Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Tapson, Victor F., Grein, Jonathan, Sutterwala, Fayyaz, Ince, Dilek, Winokur, Patricia L., Fung, Monica, Jang, Hannah, Wyles, David, Frank, Maria G., Sarcone, Ellen, Neumann, Henry, Viswanathan, Anand, Hochman, Sarah, Mulligan, Mark, Eckhardt, Benjamin, Carmody, Ellie, Ahuja, Neera, Nadeau, Kari, Svec, David, Macaraeg, Jeffrey C., Morrow, Lee, Quimby, Dave, Bessesen, Mary, Nicholson, Lindsay, Adams, Jill, Kumar, Princy, Lambert, Allison A., Arguinchona, Henry, Alicic, Radica Z., Saito, Sho, Ohmagari, Norio, Mikami, Ayako, Chien Lye, David, Hong Lee, Tau, Ying Chia, Po, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Candiotti, Keith A., Castro, Jose G., Antor, Maria A., Lee, Tida, Lalani, Tahaniyat, Novak, Richard M., Wendrow, Andrea, Borgetti, Scott A., George, Sarah L., Hoft, Daniel F., Brien, James D., Cohen, Stuart H., Thompson, George R., 3rd, Chakrabarty, Melony, Guirgis, Faheem, Davey, Richard T., Voell, Jocelyn, Strich, Jeffrey R., Lindholm, David A., Mende, Katrin, Wellington, Trevor R., Rapaka, Rekha R., Husson, Jennifer S., Levine, Andrea R., Yen Tan, Seow, Shafi, Humaira, Chien, Jaime M F, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Adams, David H., Osinusi, Anu, Cao, Huyen, Burgess, Timothy H., Rozman, Julia, Chung, Kevin K., Nieuwoudt, Christina, El-Khorazaty, Jill A., Hill, Heather, Pettibone, Stephanie, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Deye, Gregory A., Nomicos, Effie, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Wolfe, Cameron R, Tomashek, Kay M, Patterson, Thomas F, Gomez, Carlos A, Marconi, Vincent C, Jain, Mamta K, Yang, Otto O, Paules, Catharine I, Palacios, Guillermo M Ruiz, Grossberg, Robert, Harkins, Michelle S, Mularski, Richard A, Erdmann, Nathaniel, Sandkovsky, Uriel, Almasri, Eyad, Pineda, Justino Regalado, Dretler, Alexandra W, de Castilla, Diego Lopez, Branche, Angela R, Park, Pauline K, Mehta, Aneesh K, Short, William R, McLellan, Susan L F, Kline, Susan, Iovine, Nicole M, El Sahly, Hana M, Doernberg, Sarah B, Oh, Myoung-don, Huprikar, Nikhil, Hohmann, Elizabeth, Kelley, Colleen F, Holodniy, Mark, Kim, Eu Suk, Sweeney, Daniel A, Finberg, Robert W, Grimes, Kevin A, Maves, Ryan C, Ko, Emily R, Engemann, John J, Taylor, Barbara S, Ponce, Philip O, Larson, LuAnn, Melendez, Dante Paolo, Seibert, Allan M, Rouphael, Nadine G, Strebe, Joslyn, Clark, Jesse L, Julian, Kathleen G, de Leon, Alfredo Ponce, Cardoso, Anabela, de Bono, Stephanie, Atmar, Robert L, Ganesan, Anuradha, Ferreira, Jennifer L, Green, Michelle, Makowski, Mat, Bonnett, Tyler, Beresnev, Tatiana, Ghazaryan, Varduhi, Dempsey, Walla, Nayak, Seema U, Dodd, Lori E, Beigel, John H, and Kalil, Andre C
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- 2022
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6. Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure
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Marzan-Rivera, Nicole, Serrano-Collazo, Crisanta, Cruz, Lorna, Pantoja, Petraleigh, Ortiz-Rosa, Alexandra, Arana, Teresa, Martinez, Melween I., Burgos, Armando G., Roman, Chiara, Mendez, Loyda B., Geerling, Elizabeth, Pinto, Amelia K., Brien, James D., and Sariol, Carlos A.
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- 2022
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7. RECYCLING IS RUBBISH: REINVENT, REALIGN, AND RESTRUCTURE U.S. MATERIAL MANAGEMENT
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Brien, James D.
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Ecotaxes -- Laws, regulations and rules ,Tax expenditures -- Laws, regulations and rules ,Refuse containers -- Standards ,Recycling (Waste, etc.) -- Laws, regulations and rules -- Evaluation -- Management ,Government regulation ,Company business management ,Environmental issues ,Law ,Comprehensive Overhaul of Materials Management, Efficiency, and Resource Conservation Excise Tax Act (Draft) - Abstract
SUMMARY The United States currently does not have capacity to recycle its waste domestically, nor can it export the amount of waste it once did. Many states are trying to [...]
- Published
- 2022
8. COVID-19 point-of-care tests can identify low-antibody individuals: In-depth immunoanalysis of boosting benefits in a healthy cohort
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Mallory, Michael, primary, Munt, Jennifer E., additional, Narowski, Tara M., additional, Castillo, Izabella, additional, Cuadra, Edwing, additional, Pisanic, Nora, additional, Fields, Paul, additional, Powers, John M., additional, Dickson, Alexandria, additional, Harris, Rohan, additional, Wargowsky, Richard, additional, Moran, Seamus, additional, Allabban, Ahmed, additional, Raphel, Kristin, additional, McCaffrey, Timothy A., additional, Brien, James D., additional, Heaney, Christopher D., additional, Lafleur, John E., additional, Baric, Ralph S., additional, and Premkumar, Lakshmanane, additional
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- 2024
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9. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-blind, randomised, placebo-controlled, phase 3 trial
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Hewlett, Angela, Taylor, Barbara S, Bowling, Jason E, Serrano, Ruth C, Rouphael, Nadine G, Wiley, Zanthia, Phadke, Varun K, Certain, Laura, Imlay, Hannah N, Engemann, John J, Walter, Emmanuel B, Meisner, Jessica, Rajme, Sandra, Billings, Joanne, Kim, Hyun, Martinez-Orozco, Jose A, Bautista Felix, Nora, Elmor, Sammy T, Bristow, Laurel R, Mertz, Gregory, Sosa, Nestor, Bell, Taison D, West, Miranda J, Elie-Turenne, Marie-Carmelle, Grein, Jonathan, Sutterwala, Fayyaz, Gyun Choe, Pyoeng, Kyung Kang, Chang, El Sahly, Hana M, Rhie, Kevin S, Hussein, Rezhan H, Winokur, Patricia L, Mikami, Ayako, Saito, Sho, Benson, Constance A, McConnell, Kimberly, Berhe, Mezgebe, Dishner, Emma, Frank, Maria G, Sarcone, Ellen, Crouch, Pierre-Cedric B, Jang, Hannah, Jilg, Nikolaus, Perez, Katherine, Janak, Charles, Cantos, Valeria D, Rebolledo, Paulina A, Gharbin, John, Zingman, Barry S, Riska, Paul F, Falsey, Ann R, Walsh, Edward E, Branche, Angela R, Arguinchona, Henry, Arguinchona, Christa, Van Winkle, Jason W, Zea, Diego F, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Dwyer, Jay, Bainbridge, Emma, Hostler, David C, Hostler, Jordanna M, Shahan, Brian T, Hsieh, Lanny, Amin, Alpesh N, Watanabe, Miki, Short, William R, Tebas, Pablo, Baron, Jillian T, Ahuja, Neera, Ling, Evelyn, Go, Minjoung, Yang, Otto O, Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R, Hubbard, Fleesie A, Campbell, James D, Cohen, Stuart H, Thompson, George R, 3rd, Chakrabarty, Melony, Taylor, Stephanie N, Masri, Najy, Lacour, Alisha, Lee, Tida, Lalani, Tahaniyat, Lindholm, David A, Markelz, Ana Elizabeth, Mende, Katrin, Colombo, Christopher J, Schofield, Christina, Colombo, Rhonda E, Guirgis, Faheem, Holodniy, Mark, Chary, Aarthi, Bessesen, Mary, Hynes, Noreen A, Sauer, Lauren M, Marconi, Vincent C, Moanna, Abeer, Harrison, Telisha, Lye, David C, Ong, Sean W X, Ying Chia, Po, Huprikar, Nikhil, Ganesan, Anuradha, Madar, Christian, Novak, Richard M, Wendrow, Andrea, Borgetti, Scott A, George, Sarah L, Hoft, Daniel F, Brien, James D, McLellan, Susan L F, Levine, Corri, Nock, Joy, Yen Tan, Seow, Shafi, Humaira, Chien, Jaime M F, Candiotti, Keith, Finberg, Robert W, Wang, Jennifer P, Wessolossky, Mireya, Utz, Gregory C, Chambers, Susan E, Stephens, David S, Burgess, Timothy H, Rozman, Julia, Hyvert, Yann, Seitzinger, Andrea, Osinusi, Anu, Cao, Huyen, Chung, Kevin K, Conrad, Tom M, Cross, Kaitlyn, El-Khorazaty, Jill A, Hill, Heather, Pettibone, Stephanie, Wierzbicki, Michael R, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Deye, Gregory A, Nomicos, Effie, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Davey, Richard, Yokum, Tammy, Arega, Janice, Florese, Ruth, Kalil, Andre C, Mehta, Aneesh K, Patterson, Thomas F, Erdmann, Nathaniel, Gomez, Carlos A, Jain, Mamta K, Wolfe, Cameron R, Ruiz-Palacios, Guillermo M, Kline, Susan, Regalado Pineda, Justino, Luetkemeyer, Anne F, Harkins, Michelle S, Jackson, Patrick E H, Iovine, Nicole M, Tapson, Victor F, Oh, Myoung-don, Whitaker, Jennifer A, Mularski, Richard A, Paules, Catharine I, Ince, Dilek, Takasaki, Jin, Sweeney, Daniel A, Sandkovsky, Uriel, Wyles, David L, Hohmann, Elizabeth, Grimes, Kevin A, Grossberg, Robert, Laguio-Vila, Maryrose, Lambert, Allison A, Lopez de Castilla, Diego, Kim, EuSuk, Larson, LuAnn, Wan, Claire R, Traenkner, Jessica J, Ponce, Philip O, Patterson, Jan E, Goepfert, Paul A, Sofarelli, Theresa A, Mocherla, Satish, Ko, Emily R, Ponce de Leon, Alfredo, Doernberg, Sarah B, Atmar, Robert L, Maves, Ryan C, Dangond, Fernando, Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Bonnett, Tyler, Beresnev, Tatiana, Ghazaryan, Varduhi, Dempsey, Walla, Nayak, Seema U, Dodd, Lori, Tomashek, Kay M, and Beigel, John H
- Published
- 2021
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10. The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model
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de Oliveira, Leonardo C., Ribeiro, Aryádina M., Albarnaz, Jonas D., Torres, Alice A., Guimarães, Luís F. Z., Pinto, Amelia K., Parker, Scott, Doronin, Konstantin, Brien, James D., Buller, Mark R., and Bonjardim, Cláudio A.
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- 2020
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11. Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor
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Dussupt, Vincent, Sankhala, Rajeshwer S., Gromowski, Gregory D., Donofrio, Gina, De La Barrera, Rafael A., Larocca, Rafael A., Zaky, Weam, Mendez-Rivera, Letzibeth, Choe, Misook, Davidson, Edgar, McCracken, Michael K., Brien, James D., Abbink, Peter, Bai, Hongjun, Bryan, Aubrey L., Bias, Candace Hope, Berry, Irina Maljkovic, Botero, Nubia, Cook, Tanya, Doria-Rose, Nicole A., Escuer, Ariadna Grinyo i, Frimpong, Justice Akuoku, Geretz, Aviva, Hernandez, Mayda, Hollidge, Bradley S., Jian, Ningbo, Kabra, Kareem, Leggat, David J., Liu, Jinyan, Pinto, Amelia K., Rutvisuttinunt, Wiriya, Setliff, Ian, Tran, Ursula, Townsley, Samantha, Doranz, Benjamin J., Rolland, Morgane, McDermott, Adrian B., Georgiev, Ivelin S., Thomas, Rasmi, Robb, Merlin L., Eckels, Kenneth H., Barranco, Elizabeth, Koren, Michael, Smith, Darci R., Jarman, Richard G., George, Sarah L., Stephenson, Kathryn E., Barouch, Dan H., Modjarrad, Kayvon, Michael, Nelson L., Joyce, M. Gordon, and Krebs, Shelly J.
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- 2020
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12. The Temporal Role of Cytokines in Flavivirus Protection and Pathogenesis
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Hassert, Mariah, Brien, James D., and Pinto, Amelia K.
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- 2019
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13. Identification of immunodominant T cell epitopes induced by natural Zika virus infection
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Eickhoff, Christopher S., primary, Meza, Krystal A., additional, Terry, Frances E., additional, Colbert, Chase G., additional, Blazevic, Azra, additional, Gutiérrez, Andres H., additional, Stone, E. Taylor, additional, Brien, James D., additional, Pinto, Amelia K., additional, El Sahly, Hana M., additional, Mulligan, Mark J., additional, Rouphael, Nadine, additional, Alcaide, Maria L., additional, Tomashek, Kay M., additional, Focht, Chris, additional, Martin, William D., additional, Moise, Leonard, additional, De Groot, Anne S., additional, and Hoft, Daniel F., additional
- Published
- 2023
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14. The role of vaccination route with an adenovirus-vectored vaccine in protection, viral control, and transmission in the SARS-CoV-2/K18-hACE2 mouse infection model
- Author
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Dickson, Alexandria, primary, Geerling, Elizabeth, additional, Stone, E. Taylor, additional, Hassert, Mariah, additional, Steffen, Tara L., additional, Makkena, Taneesh, additional, Smither, Madeleine, additional, Schwetye, Katherine E., additional, Zhang, Jianfeng, additional, Georges, Bertrand, additional, Roberts, M. Scot, additional, Suschak, John J., additional, Pinto, Amelia K., additional, and Brien, James D., additional
- Published
- 2023
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15. Corrigendum: Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population
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Martel, Fabiola, primary, Cuervo-Rojas, Juliana, additional, Ángel, Juana, additional, Ariza, Beatriz, additional, González, John Mario, additional, Ramírez-Santana, Carolina, additional, Acosta-Ampudia, Yeny, additional, Murcia-Soriano, Luisa, additional, Montoya, Norma, additional, Cardozo-Romero, Claudia Cecilia, additional, Valderrama-Beltrán, Sandra Liliana, additional, Cepeda, Magda, additional, Castellanos, Julio César, additional, Gómez-Restrepo, Carlos, additional, Perdomo-Celis, Federico, additional, Gazquez, Andreu, additional, Dickson, Alexandria, additional, Brien, James D., additional, Mateus, José, additional, Grifoni, Alba, additional, Sette, Alessandro, additional, Weiskopf, Daniela, additional, and Franco, Manuel A., additional
- Published
- 2023
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- View/download PDF
16. Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population
- Author
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Martel, Fabiola, primary, Cuervo-Rojas, Juliana, additional, Ángel, Juana, additional, Ariza, Beatriz, additional, González, John Mario, additional, Ramírez-Santana, Carolina, additional, Acosta-Ampudia, Yeny, additional, Murcia-Soriano, Luisa, additional, Montoya, Norma, additional, Cardozo-Romero, Claudia Cecilia, additional, Valderrama-Beltrán, Sandra Liliana, additional, Cepeda, Magda, additional, Castellanos, Julio César, additional, Gómez-Restrepo, Carlos, additional, Perdomo-Celis, Federico, additional, Gazquez, Andreu, additional, Dickson, Alexandria, additional, Brien, James D., additional, Mateus, José, additional, Grifoni, Alba, additional, Sette, Alessandro, additional, Weiskopf, Daniela, additional, and Franco, Manuel A., additional
- Published
- 2023
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17. Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model
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Kumar, Amrendra, Suryadevara, Naveen Chandra, Wolf, Kyle J., Wilson, John T., Di Paolo, Richard J., Brien, James D., and Joyce, Sebastian
- Published
- 2020
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18. Longitudinal Analysis of Humoral and Cellular Immune Response Following SARS-CoV-2 Vaccination Supports Utilizing Point-Of-Care Tests to Enhance COVID-19 Booster Uptake
- Author
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Mallory, Michael, primary, Munt, Jennifer E., additional, Narowski, Tara M., additional, Castillo, Izabella, additional, Cuadra, Edwing, additional, Pisanic, Nora, additional, Fields, Paul, additional, Powers, John M., additional, Dickson, Alexandria, additional, Harris, Rohan, additional, Wargowsky, Richard, additional, Moran, Seamus, additional, Allabban, Ahmed, additional, Raphel, Kristin, additional, McCaffrey, Timothy A., additional, Brien, James D., additional, Heaney, Christopher D., additional, Lafleur, John E., additional, Baric, Ralph S., additional, and Premkumar, Lakshmanane, additional
- Published
- 2023
- Full Text
- View/download PDF
19. Time elapsed between Zika and dengue virus infections affects antibody and T cell responses
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Pérez-Guzmán, Erick X., Pantoja, Petraleigh, Serrano-Collazo, Crisanta, Hassert, Mariah A., Ortiz-Rosa, Alexandra, Rodríguez, Idia V., Giavedoni, Luis, Hodara, Vida, Parodi, Laura, Cruz, Lorna, Arana, Teresa, White, Laura J., Martínez, Melween I., Weiskopf, Daniela, Brien, James D., de Silva, Aravinda, Pinto, Amelia K., and Sariol, Carlos A.
- Published
- 2019
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20. Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population.
- Author
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Martel, Fabiola, Cuervo-Rojas, Juliana, ngel, Juana á, Ariza, Beatriz, González, John Mario, Ramírez-Santana, Carolina, Acosta-Ampudia, Yeny, Murcia-Soriano, Luisa, Montoya, Norma, Cardozo-Romero, Claudia Cecilia, Valderrama-Beltrán8, Sandra Liliana, Cepeda, Magda, Castellanos, Julio César, Gómez-Restrepo, Carlos, Perdomo-Celis, Federico, Gazquez, Andreu, Dickson, Alexandria, Brien, James D., Mateus, José, and Grifoni, Alba
- Subjects
T cells ,SARS-CoV-2 ,SARS-CoV-2 Delta variant ,ANTIBODY titer ,BREAKTHROUGH infections - Abstract
The SARS CoV-2 antibody and CD4
+ T cell responses induced by natural infection and/or vaccination decline over time and cross-recognize other viral variants at different levels. However, there are few studies evaluating the levels and durability of the SARS CoV-2-specific antibody and CD4+ T cell response against the Mu, Gamma, and Delta variants. Here, we examined, in two ambispective cohorts of naturally-infected and/or vaccinated individuals, the titers of anti-RBD antibodies and the frequency of SARS-CoV-2-specific CD4+ T cells up to 6 months after the last antigen exposure. In naturally-infected individuals, the SARS-CoV-2 antibody response declined 6 months postsymptoms onset. However, the kinetic observed depended on the severity of the disease, since individuals who developed severe COVID-19 maintained the binding antibody titers. Also, there was detectable binding antibody cross-recognition for the Gamma, Mu, and Delta variants, but antibodies poorly neutralized Mu. COVID-19 vaccines induced an increase in antibody titers 15-30 days after receiving the second dose, but these levels decreased at 6 months. However, as expected, a third dose of the vaccine caused a rise in antibody titers. The dynamics of the antibody response upon vaccination depended on the previous SARS-CoV-2 exposure. Lower levels of vaccine-induced antibodies were associated with the development of breakthrough infections. Vaccination resulted in central memory spike-specific CD4+ T cell responses that cross-recognized peptides from the Gamma and Mu variants, and their duration also depended on previous SARS-CoV-2 exposure. In addition, we found cross-reactive CD4+ T cell responses in unexposed and unvaccinated individuals. These results have important implications for vaccine design for new SARS-CoV-2 variants of interest and concern. [ABSTRACT FROM AUTHOR]- Published
- 2023
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21. Metal coordinating inhibitors of Rift Valley fever virus replication
- Author
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Geerling, Elizabeth, primary, Murphy, Valerie, additional, Mai, Maria C., additional, Stone, E. Taylor, additional, Casals, Andreu Gazquez, additional, Hassert, Mariah, additional, O’Dea, Austin T., additional, Cao, Feng, additional, Donlin, Maureen J., additional, Elagawany, Mohamed, additional, Elgendy, Bahaa, additional, Pardali, Vasiliki, additional, Giannakopoulou, Erofili, additional, Zoidis, Grigoris, additional, Schiavone, Daniel V., additional, Berkowitz, Alex J., additional, Agyemang, Nana B., additional, Murelli, Ryan P., additional, Tavis, John E., additional, Pinto, Amelia K., additional, and Brien, James D., additional
- Published
- 2022
- Full Text
- View/download PDF
22. Titration and neutralizing antibody quantification by focus forming assay for Powassan virus
- Author
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Stone, E. Taylor, primary, Hirsch, Alec J., additional, Smith, Jessica L., additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2022
- Full Text
- View/download PDF
23. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
- Author
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Wolfe, Cameron R, primary, Tomashek, Kay M, additional, Patterson, Thomas F, additional, Gomez, Carlos A, additional, Marconi, Vincent C, additional, Jain, Mamta K, additional, Yang, Otto O, additional, Paules, Catharine I, additional, Palacios, Guillermo M Ruiz, additional, Grossberg, Robert, additional, Harkins, Michelle S, additional, Mularski, Richard A, additional, Erdmann, Nathaniel, additional, Sandkovsky, Uriel, additional, Almasri, Eyad, additional, Pineda, Justino Regalado, additional, Dretler, Alexandra W, additional, de Castilla, Diego Lopez, additional, Branche, Angela R, additional, Park, Pauline K, additional, Mehta, Aneesh K, additional, Short, William R, additional, McLellan, Susan L F, additional, Kline, Susan, additional, Iovine, Nicole M, additional, El Sahly, Hana M, additional, Doernberg, Sarah B, additional, Oh, Myoung-don, additional, Huprikar, Nikhil, additional, Hohmann, Elizabeth, additional, Kelley, Colleen F, additional, Holodniy, Mark, additional, Kim, Eu Suk, additional, Sweeney, Daniel A, additional, Finberg, Robert W, additional, Grimes, Kevin A, additional, Maves, Ryan C, additional, Ko, Emily R, additional, Engemann, John J, additional, Taylor, Barbara S, additional, Ponce, Philip O, additional, Larson, LuAnn, additional, Melendez, Dante Paolo, additional, Seibert, Allan M, additional, Rouphael, Nadine G, additional, Strebe, Joslyn, additional, Clark, Jesse L, additional, Julian, Kathleen G, additional, de Leon, Alfredo Ponce, additional, Cardoso, Anabela, additional, de Bono, Stephanie, additional, Atmar, Robert L, additional, Ganesan, Anuradha, additional, Ferreira, Jennifer L, additional, Green, Michelle, additional, Makowski, Mat, additional, Bonnett, Tyler, additional, Beresnev, Tatiana, additional, Ghazaryan, Varduhi, additional, Dempsey, Walla, additional, Nayak, Seema U, additional, Dodd, Lori E, additional, Beigel, John H, additional, Kalil, Andre C, additional, Wahid, Lana, additional, Walter, Emmanuel B., additional, Belur, Akhila G., additional, Dreyer, Grace, additional, Patterson, Jan E., additional, Bowling, Jason E., additional, Dixon, Danielle O., additional, Hewlett, Angela, additional, Odrobina, Robert, additional, Pupaibool, Jakrapun, additional, Mocherla, Satish, additional, Lazarte, Suzana, additional, Cayabyab, Meilani, additional, Hussein, Rezhan H., additional, Golamari, Reshma R., additional, Krill, Kaleigh L., additional, Rajme, Sandra, additional, Riska, Paul F., additional, Zingman, Barry S., additional, Mertz, Gregory, additional, Sosa, Nestor, additional, Goepfert, Paul A., additional, Berhe, Mezgebe, additional, Dishner, Emma, additional, Fayed, Mohamed, additional, Hubel, Kinsley, additional, Martinez-Orozco, José Arturo, additional, Bautista Felix, Nora, additional, Elmor, Sammy T., additional, Bechnak, Amer Ryan, additional, Saklawi, Youssef, additional, Van Winkle, Jason W., additional, Zea, Diego F., additional, Laguio-Vila, Maryrose, additional, Walsh, Edward E., additional, Falsey, Ann R., additional, Carvajal, Karen, additional, Hyzy, Robert C., additional, Hanna, Sinan, additional, Olbrich, Norman, additional, Traenkner, Jessica J., additional, Kraft, Colleen S., additional, Tebas, Pablo, additional, Baron, Jillian T, additional, Levine, Corri, additional, Nock, Joy, additional, Billings, Joanne, additional, Kim, Hyun, additional, Elie-Turenne, Marie-Carmelle, additional, Whitaker, Jennifer A., additional, Luetkemeyer, Anne F., additional, Dwyer, Jay, additional, Bainbridge, Emma, additional, Gyun Choe, Pyoeng, additional, Kyung Kang, Chang, additional, Jilg, Nikolaus, additional, Cantos, Valeria D, additional, Bhamidipati, Divya R., additional, Nithin Gopalsamy, Srinivasa, additional, Chary, Aarthi, additional, Jung, Jongtak, additional, Song, Kyoung-Ho, additional, Kim, Hong Bin, additional, Benson, Constance A., additional, McConnell, Kimberly, additional, Wang, Jennifer P., additional, Wessolossky, Mireya, additional, Perez, Katherine, additional, Eubank, Taryn A, additional, Berjohn, Catherine, additional, Utz, Gregory C., additional, Jackson, Patrick E.H., additional, Bell, Taison D., additional, Haughey, Heather M., additional, Moanna, Abeer, additional, Cribbs, Sushma, additional, Harrison, Telisha, additional, Colombo, Christopher J., additional, Schofield, Christina, additional, Colombo, Rhonda E., additional, Tapson, Victor F., additional, Grein, Jonathan, additional, Sutterwala, Fayyaz, additional, Ince, Dilek, additional, Winokur, Patricia L., additional, Fung, Monica, additional, Jang, Hannah, additional, Wyles, David, additional, Frank, Maria G., additional, Sarcone, Ellen, additional, Neumann, Henry, additional, Viswanathan, Anand, additional, Hochman, Sarah, additional, Mulligan, Mark, additional, Eckhardt, Benjamin, additional, Carmody, Ellie, additional, Ahuja, Neera, additional, Nadeau, Kari, additional, Svec, David, additional, Macaraeg, Jeffrey C., additional, Morrow, Lee, additional, Quimby, Dave, additional, Bessesen, Mary, additional, Nicholson, Lindsay, additional, Adams, Jill, additional, Kumar, Princy, additional, Lambert, Allison A., additional, Arguinchona, Henry, additional, Alicic, Radica Z., additional, Saito, Sho, additional, Ohmagari, Norio, additional, Mikami, Ayako, additional, Chien Lye, David, additional, Hong Lee, Tau, additional, Ying Chia, Po, additional, Hsieh, Lanny, additional, Amin, Alpesh N., additional, Watanabe, Miki, additional, Candiotti, Keith A., additional, Castro, Jose G., additional, Antor, Maria A., additional, Lee, Tida, additional, Lalani, Tahaniyat, additional, Novak, Richard M., additional, Wendrow, Andrea, additional, Borgetti, Scott A., additional, George, Sarah L., additional, Hoft, Daniel F., additional, Brien, James D., additional, Cohen, Stuart H., additional, Thompson, George R., additional, Chakrabarty, Melony, additional, Guirgis, Faheem, additional, Davey, Richard T., additional, Voell, Jocelyn, additional, Strich, Jeffrey R., additional, Lindholm, David A., additional, Mende, Katrin, additional, Wellington, Trevor R., additional, Rapaka, Rekha R., additional, Husson, Jennifer S., additional, Levine, Andrea R., additional, Yen Tan, Seow, additional, Shafi, Humaira, additional, Chien, Jaime M F, additional, Hostler, David C., additional, Hostler, Jordanna M., additional, Shahan, Brian T., additional, Adams, David H., additional, Osinusi, Anu, additional, Cao, Huyen, additional, Burgess, Timothy H., additional, Rozman, Julia, additional, Chung, Kevin K., additional, Nieuwoudt, Christina, additional, El-Khorazaty, Jill A., additional, Hill, Heather, additional, Pettibone, Stephanie, additional, Gettinger, Nikki, additional, Engel, Theresa, additional, Lewis, Teri, additional, Wang, Jing, additional, Deye, Gregory A., additional, Nomicos, Effie, additional, Pikaart-Tautges, Rhonda, additional, Elsafy, Mohamed, additional, Jurao, Robert, additional, Koo, Hyung, additional, Proschan, Michael, additional, Yokum, Tammy, additional, Arega, Janice, additional, and Florese, Ruth, additional
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- 2022
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24. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization
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Karger, Amy B., primary, Brien, James D., additional, Christen, Jayne M., additional, Dhakal, Santosh, additional, Kemp, Troy J., additional, Klein, Sabra L., additional, Pinto, Ligia A., additional, PREMKUMAR, LAKSHMANANE, additional, Roback, John D., additional, Binder, Raquel A., additional, Boehme, Karl William, additional, Boppana, Suresh, additional, Crawford, James M., additional, Daiss, John L, additional, Dupuis, Alan P., additional, Espino, Ana M, additional, Forconi, Catherine, additional, Forrest, J. Craig, additional, Girardin, Roxie C., additional, Haddad, Natalie S., additional, Heaney, Christopher D, additional, Hunt, Danielle T., additional, Kennedy, Joshua L, additional, King, Christopher L., additional, Kruczynski, Kate, additional, LaBaer, Joshua, additional, Lee, F. Eun-Hyung, additional, Lee, William T., additional, Liu, Shan-Lu, additional, Lozanski, Gerard, additional, Moormann, Ann M., additional, Murugan, Vel, additional, Okoye, Nkemakonam C., additional, Pantoja, Petraleigh, additional, Payne, Anne F., additional, Park, Jin, additional, Pinninti, Swetha, additional, Pinto, Amelia K, additional, Pisanic, Nora, additional, Qiu, Ji, additional, Sariol, Carlos A, additional, Song, Lusheng, additional, Steffen, Tara L., additional, Stone, E. Taylor, additional, Styer, Linda M., additional, Suthar, Mehul S, additional, Thomas, Stefani N., additional, Thyagarajan, Bharat, additional, Yates, Jennifer L, additional, and Sobhani, Kimia, additional
- Published
- 2022
- Full Text
- View/download PDF
25. Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination
- Author
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Stone, E. Taylor, primary, Hassert, Mariah, additional, Geerling, Elizabeth, additional, Wagner, Colleen, additional, Brien, James D., additional, Ebel, Gregory D., additional, Hirsch, Alec J., additional, German, Cody, additional, Smith, Jessica L., additional, and Pinto, Amelia K., additional
- Published
- 2022
- Full Text
- View/download PDF
26. Infection Order Outweighs the Role of CD4 + T Cells in Tertiary Flavivirus Infection
- Author
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Marzan-Rivera, Nicole, primary, Serrano-Collazo, Crisanta, additional, Cruz, Lorna, additional, Pantoja, Petraleigh, additional, Ortiz-Rosa, Alexandra, additional, Arana, Teresa, additional, Martinez, Melween I., additional, Burgos, Armando G., additional, Roman, Chiara, additional, Geerling, Elizabeth, additional, Brien, James D., additional, Pinto, Amelia K., additional, Mendez, Loyda B., additional, and Sariol, Carlos A., additional
- Published
- 2022
- Full Text
- View/download PDF
27. Roles of antiviral sensing and type I interferon signaling in the restriction of SARS-CoV-2 replication
- Author
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Geerling, Elizabeth, primary, Pinski, Amanda N., additional, Stone, Taylor E., additional, DiPaolo, Richard J., additional, Zulu, Michael Z., additional, Maroney, Kevin J., additional, Brien, James D., additional, Messaoudi, Ilhem, additional, and Pinto, Amelia K., additional
- Published
- 2022
- Full Text
- View/download PDF
28. Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-blind, randomised, placebo-controlled, phase 3 trial
- Author
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Kalil, Andre C, primary, Mehta, Aneesh K, additional, Patterson, Thomas F, additional, Erdmann, Nathaniel, additional, Gomez, Carlos A, additional, Jain, Mamta K, additional, Wolfe, Cameron R, additional, Ruiz-Palacios, Guillermo M, additional, Kline, Susan, additional, Regalado Pineda, Justino, additional, Luetkemeyer, Anne F, additional, Harkins, Michelle S, additional, Jackson, Patrick E H, additional, Iovine, Nicole M, additional, Tapson, Victor F, additional, Oh, Myoung-don, additional, Whitaker, Jennifer A, additional, Mularski, Richard A, additional, Paules, Catharine I, additional, Ince, Dilek, additional, Takasaki, Jin, additional, Sweeney, Daniel A, additional, Sandkovsky, Uriel, additional, Wyles, David L, additional, Hohmann, Elizabeth, additional, Grimes, Kevin A, additional, Grossberg, Robert, additional, Laguio-Vila, Maryrose, additional, Lambert, Allison A, additional, Lopez de Castilla, Diego, additional, Kim, EuSuk, additional, Larson, LuAnn, additional, Wan, Claire R, additional, Traenkner, Jessica J, additional, Ponce, Philip O, additional, Patterson, Jan E, additional, Goepfert, Paul A, additional, Sofarelli, Theresa A, additional, Mocherla, Satish, additional, Ko, Emily R, additional, Ponce de Leon, Alfredo, additional, Doernberg, Sarah B, additional, Atmar, Robert L, additional, Maves, Ryan C, additional, Dangond, Fernando, additional, Ferreira, Jennifer, additional, Green, Michelle, additional, Makowski, Mat, additional, Bonnett, Tyler, additional, Beresnev, Tatiana, additional, Ghazaryan, Varduhi, additional, Dempsey, Walla, additional, Nayak, Seema U, additional, Dodd, Lori, additional, Tomashek, Kay M, additional, Beigel, John H, additional, Hewlett, Angela, additional, Taylor, Barbara S, additional, Bowling, Jason E, additional, Serrano, Ruth C, additional, Rouphael, Nadine G, additional, Wiley, Zanthia, additional, Phadke, Varun K, additional, Certain, Laura, additional, Imlay, Hannah N, additional, Engemann, John J, additional, Walter, Emmanuel B, additional, Meisner, Jessica, additional, Rajme, Sandra, additional, Billings, Joanne, additional, Kim, Hyun, additional, Martinez-Orozco, Jose A, additional, Bautista Felix, Nora, additional, Elmor, Sammy T, additional, Bristow, Laurel R, additional, Mertz, Gregory, additional, Sosa, Nestor, additional, Bell, Taison D, additional, West, Miranda J, additional, Elie-Turenne, Marie-Carmelle, additional, Grein, Jonathan, additional, Sutterwala, Fayyaz, additional, Gyun Choe, Pyoeng, additional, Kyung Kang, Chang, additional, El Sahly, Hana M, additional, Rhie, Kevin S, additional, Hussein, Rezhan H, additional, Winokur, Patricia L, additional, Mikami, Ayako, additional, Saito, Sho, additional, Benson, Constance A, additional, McConnell, Kimberly, additional, Berhe, Mezgebe, additional, Dishner, Emma, additional, Frank, Maria G, additional, Sarcone, Ellen, additional, Crouch, Pierre-Cedric B, additional, Jang, Hannah, additional, Jilg, Nikolaus, additional, Perez, Katherine, additional, Janak, Charles, additional, Cantos, Valeria D, additional, Rebolledo, Paulina A, additional, Gharbin, John, additional, Zingman, Barry S, additional, Riska, Paul F, additional, Falsey, Ann R, additional, Walsh, Edward E, additional, Branche, Angela R, additional, Arguinchona, Henry, additional, Arguinchona, Christa, additional, Van Winkle, Jason W, additional, Zea, Diego F, additional, Jung, Jongtak, additional, Song, Kyoung-Ho, additional, Kim, Hong Bin, additional, Dwyer, Jay, additional, Bainbridge, Emma, additional, Hostler, David C, additional, Hostler, Jordanna M, additional, Shahan, Brian T, additional, Hsieh, Lanny, additional, Amin, Alpesh N, additional, Watanabe, Miki, additional, Short, William R, additional, Tebas, Pablo, additional, Baron, Jillian T, additional, Ahuja, Neera, additional, Ling, Evelyn, additional, Go, Minjoung, additional, Yang, Otto O, additional, Ahn, Jenny, additional, Arias, Rubi, additional, Rapaka, Rekha R, additional, Hubbard, Fleesie A, additional, Campbell, James D, additional, Cohen, Stuart H, additional, Thompson, George R, additional, Chakrabarty, Melony, additional, Taylor, Stephanie N, additional, Masri, Najy, additional, Lacour, Alisha, additional, Lee, Tida, additional, Lalani, Tahaniyat, additional, Lindholm, David A, additional, Markelz, Ana Elizabeth, additional, Mende, Katrin, additional, Colombo, Christopher J, additional, Schofield, Christina, additional, Colombo, Rhonda E, additional, Guirgis, Faheem, additional, Holodniy, Mark, additional, Chary, Aarthi, additional, Bessesen, Mary, additional, Hynes, Noreen A, additional, Sauer, Lauren M, additional, Marconi, Vincent C, additional, Moanna, Abeer, additional, Harrison, Telisha, additional, Lye, David C, additional, Ong, Sean W X, additional, Ying Chia, Po, additional, Huprikar, Nikhil, additional, Ganesan, Anuradha, additional, Madar, Christian, additional, Novak, Richard M, additional, Wendrow, Andrea, additional, Borgetti, Scott A, additional, George, Sarah L, additional, Hoft, Daniel F, additional, Brien, James D, additional, McLellan, Susan L F, additional, Levine, Corri, additional, Nock, Joy, additional, Yen Tan, Seow, additional, Shafi, Humaira, additional, Chien, Jaime M F, additional, Candiotti, Keith, additional, Finberg, Robert W, additional, Wang, Jennifer P, additional, Wessolossky, Mireya, additional, Utz, Gregory C, additional, Chambers, Susan E, additional, Stephens, David S, additional, Burgess, Timothy H, additional, Rozman, Julia, additional, Hyvert, Yann, additional, Seitzinger, Andrea, additional, Osinusi, Anu, additional, Cao, Huyen, additional, Chung, Kevin K, additional, Conrad, Tom M, additional, Cross, Kaitlyn, additional, El-Khorazaty, Jill A, additional, Hill, Heather, additional, Pettibone, Stephanie, additional, Wierzbicki, Michael R, additional, Gettinger, Nikki, additional, Engel, Theresa, additional, Lewis, Teri, additional, Wang, Jing, additional, Deye, Gregory A, additional, Nomicos, Effie, additional, Pikaart-Tautges, Rhonda, additional, Elsafy, Mohamed, additional, Jurao, Robert, additional, Koo, Hyung, additional, Proschan, Michael, additional, Davey, Richard, additional, Yokum, Tammy, additional, Arega, Janice, additional, and Florese, Ruth, additional
- Published
- 2021
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29. Corticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulation
- Author
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Pinski, Amanda N, primary, Steffen, Tara L, additional, Zulu, Michael Z, additional, George, Sarah L, additional, Dickson, Alexandria, additional, Tifrea, Delia, additional, Maroney, Kevin J, additional, Tedeschi, Neil, additional, Zhang, Yun, additional, Scheuermann, Richard H, additional, Pinto, Amelia K, additional, Brien, James D, additional, and Messaoudi, Ilhem, additional
- Published
- 2021
- Full Text
- View/download PDF
30. The Ability of Zika virus Intravenous Immunoglobulin to Protect From or Enhance Zika Virus Disease
- Author
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Pinto, Amelia K., primary, Hassert, Mariah, additional, Han, Xiaobing, additional, Barker, Douglas, additional, Carnelley, Trevor, additional, Branche, Emilie, additional, Steffen, Tara L., additional, Stone, E. Taylor, additional, Geerling, Elizabeth, additional, Viramontes, Karla M., additional, Nykiforuk, Cory, additional, Toth, Derek, additional, Shresta, Sujan, additional, Kodihalli, Shantha, additional, and Brien, James D., additional
- Published
- 2021
- Full Text
- View/download PDF
31. Obesity Enhances Disease Severity in Female Mice Following West Nile Virus Infection
- Author
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Geerling, Elizabeth, primary, Stone, E. Taylor, additional, Steffen, Tara L., additional, Hassert, Mariah, additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2021
- Full Text
- View/download PDF
32. Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge
- Author
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King, R. Glenn, primary, Silva-Sanchez, Aaron, additional, Peel, Jessica N., additional, Botta, Davide, additional, Dickson, Alexandria M., additional, Pinto, Amelia K., additional, Meza-Perez, Selene, additional, Allie, S. Rameeza, additional, Schultz, Michael D., additional, Liu, Mingyong, additional, Bradley, John E., additional, Qiu, Shihong, additional, Yang, Guang, additional, Zhou, Fen, additional, Zumaquero, Esther, additional, Simpler, Thomas S., additional, Mousseau, Betty, additional, Killian, John T., additional, Dean, Brittany, additional, Shang, Qiao, additional, Tipper, Jennifer L., additional, Risley, Christopher A., additional, Harrod, Kevin S., additional, Feng, Tsungwei, additional, Lee, Young, additional, Shiberu, Bethlehem, additional, Krishnan, Vyjayanthi, additional, Peguillet, Isabelle, additional, Zhang, Jianfeng, additional, Green, Todd J., additional, Randall, Troy D., additional, Suschak, John J., additional, Georges, Bertrand, additional, Brien, James D., additional, Lund, Frances E., additional, and Roberts, M. Scot, additional
- Published
- 2021
- Full Text
- View/download PDF
33. Selective estrogen receptor modulator, tamoxifen, inhibits Zika virus infection
- Author
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Grady, Scott F., primary, Pinto, Amelia K., additional, Hassert, Mariah, additional, D'Angelo, June A., additional, Brien, James D., additional, and Arnatt, Christopher K., additional
- Published
- 2021
- Full Text
- View/download PDF
34. Prior Heterologous Flavivirus Exposure Results in Reduced Pathogenesis in a Mouse Model of Zika Virus Infection
- Author
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Hassert, Mariah, primary, Steffen, Tara L., additional, Scroggins, Stephen, additional, Coleman, Abigail K., additional, Shacham, Enbal, additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2021
- Full Text
- View/download PDF
35. Function is more reliable than quantity to follow up the humoral response to the Receptor Binding Domain of SARS-CoV-2 Spike protein after natural infection or COVID-19 vaccination
- Author
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Sariol, Carlos A., primary, Pantoja, Petraleigh, additional, Serrano-Collazo, Crisanta, additional, Rosa-Arocho, Tiffany, additional, Armina, Albersy, additional, Cruz, Lorna, additional, Stone, E. Taylor, additional, Arana, Teresa, additional, Climent, Consuelo, additional, Latoni, Gerardo, additional, Atehortua, Dianne, additional, Pabon-Carrero, Christina, additional, Pinto, Amelia K., additional, Brien, James D., additional, and Espino, Ana M., additional
- Published
- 2021
- Full Text
- View/download PDF
36. A Dengue Virus Serotype 1 mRNA-LNP Vaccine Elicits Protective Immune Responses
- Author
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Wollner, Clayton J., primary, Richner, Michelle, additional, Hassert, Mariah A., additional, Pinto, Amelia K., additional, Brien, James D., additional, and Richner, Justin M., additional
- Published
- 2021
- Full Text
- View/download PDF
37. Pre-existing T Cell Memory against Zika Virus
- Author
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Schouest, Blake, primary, Grifoni, Alba, additional, Pham, John, additional, Mateus, Jose, additional, Sydney, John, additional, Brien, James D., additional, De Silva, Aruna D., additional, Balmaseda, Angel, additional, Harris, Eva, additional, Sette, Alessandro, additional, and Weiskopf, Daniela, additional
- Published
- 2021
- Full Text
- View/download PDF
38. T cell cross-reactivity during heterologous infection results in immunodomination and enhanced cytolytic capacity at the expense of virus-specific responses
- Author
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Hassert, Mariah, primary, Brien, James D, additional, and Pinto, Amelia K, additional
- Published
- 2021
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- View/download PDF
39. The impact of type I interferon driven cytokines on the plasmablast response to viral pathogens
- Author
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Steffen, Tara L, primary, Hassert, Mariah, additional, and Brien, James D, additional
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- 2021
- Full Text
- View/download PDF
40. T cell responses induced by attenuated flavivirus vaccination are specific and show limited cross-reactivity with other flavivirus species
- Author
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Grifoni, Alba, Voic, Hannah, Dhanda, Sandeep Kumar, Kidd, Conner K., Brien, James D., Buus, Søren, Stryhn, Anette, Durbin, Anna P., Whitehead, Stephen, Diehl, Sean A., De Silva, Aruna D., Balmaseda, Angel, Harris, Eva, Weiskopf, Daniela, Sette, Alessandro, Grifoni, Alba, Voic, Hannah, Dhanda, Sandeep Kumar, Kidd, Conner K., Brien, James D., Buus, Søren, Stryhn, Anette, Durbin, Anna P., Whitehead, Stephen, Diehl, Sean A., De Silva, Aruna D., Balmaseda, Angel, Harris, Eva, Weiskopf, Daniela, and Sette, Alessandro
- Abstract
Members of the flavivirus genus share a high level of sequence similarity and often circulate in the same geographical regions. However, whether T cells induced by one viral species cross-react with other related flaviviruses has not been globally addressed. In this study, we tested pools of epitopes derived from dengue (DENV), Zika (ZIKV), Japanese encephalitis (JEV), West Nile (WNV), and yellow fever (YFV) viruses by intracellular cytokine staining (ICS) using peripheral blood mononuclear cells (PBMCs) of individuals naturally exposed to DENV or immunized with DENV (TV005) or YF17D vaccine. CD8 T cell responses recognized epitopes from multiple flaviviruses; however, the magnitude of cross-reactive responses was consistently severalfold lower than those to the autologous epitope pools and was associated with lower expression of activation markers such as CD40L, CD69, and CD137. Next, we characterized the antigen sensitivity of short-Term T cell lines (TCL) representing 29 different individual epitope/donor combinations. TCL derived from DENV monovalent vaccinees induced CD8 and CD4 T cells that cross-reacted within the DENV serocomplex but were consistently associated with > 100-fold-lower antigen sensitivity for most other flaviviruses, with no cross-recognition of YFV-derived peptides. CD8 and CD4 TCL from YF17D vaccinees were associated with very limited cross-reactivity with any other flaviviruses and in five out of eight cases > 1,000-foldlower antigen sensitivity. Overall, our data suggest limited cross-reactivity for both CD4 and CD8 T cell responses between flaviviruses and have implications for understanding immunity elicited by natural infection and strategies to develop live attenuated vaccines against flaviviral species.
- Published
- 2020
41. A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-specific immunity
- Author
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Wollner, Clayton J., primary, Richner, Michelle, additional, Hassert, Mariah A., additional, Pinto, Amelia K., additional, Brien, James D., additional, and Richner, Justin M., additional
- Published
- 2021
- Full Text
- View/download PDF
42. Heterologous flavivirus exposure provides varying degrees of cross-protection from Zika virus in a mouse model of infection
- Author
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Hassert, Mariah, primary, Scroggins, Stephen, additional, Coleman, Abigail K., additional, Shacham, Enbal, additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2020
- Full Text
- View/download PDF
43. mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2
- Author
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Hassert, Mariah, primary, Geerling, Elizabeth, additional, Stone, E. Taylor, additional, Steffen, Tara L., additional, Feldman, Madi S., additional, Dickson, Alexandria L., additional, Class, Jacob, additional, Richner, Justin M., additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2020
- Full Text
- View/download PDF
44. Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice
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Hassert, Mariah, primary, Wolf, Kyle J., additional, Rajeh, Ahmad, additional, Schiebout, Courtney, additional, Hoft, Stella G., additional, Ahn, Tae-Hyuk, additional, DiPaolo, Richard J., additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2020
- Full Text
- View/download PDF
45. Human iPSC-Derived Neuronal Cells From CTBP1-Mutated Patients Reveal Altered Expression of Neurodevelopmental Gene Networks
- Author
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Vijayalingam, S., primary, Ezekiel, Uthayashanker R., additional, Xu, Fenglian, additional, Subramanian, T., additional, Geerling, Elizabeth, additional, Hoelscher, Brittany, additional, San, KayKay, additional, Ganapathy, Aravinda, additional, Pemberton, Kyle, additional, Tycksen, Eric, additional, Pinto, Amelia K., additional, Brien, James D., additional, Beck, David B., additional, Chung, Wendy K., additional, Gurnett, Christina A., additional, and Chinnadurai, G., additional
- Published
- 2020
- Full Text
- View/download PDF
46. Current Flavivirus Research Important for Vaccine Development
- Author
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Geerling, Elizabeth, primary, Steffen, Tara L., additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2020
- Full Text
- View/download PDF
47. The receptor binding domain of SARS-CoV-2 spike is the key target of neutralizing antibody in human polyclonal sera
- Author
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Steffen, Tara L., primary, Stone, E. Taylor, additional, Hassert, Mariah, additional, Geerling, Elizabeth, additional, Grimberg, Brian T., additional, Espino, Ana M., additional, Pantoja, Petraleigh, additional, Climent, Consuelo, additional, Hoft, Daniel F., additional, George, Sarah L., additional, Sariol, Carlos A., additional, Pinto, Amelia K., additional, and Brien, James D., additional
- Published
- 2020
- Full Text
- View/download PDF
48. Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
- Author
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Stone, E. Taylor, primary, Geerling, Elizabeth, additional, Steffen, Tara L., additional, Hassert, Mariah, additional, Dickson, Alexandria, additional, Spencer, Jacqueline F., additional, Toth, Karoly, additional, DiPaolo, Richard J., additional, Brien, James D., additional, and Pinto, Amelia K., additional
- Published
- 2020
- Full Text
- View/download PDF
49. Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies
- Author
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Serrano-Collazo, Crisanta, primary, Pérez-Guzmán, Erick X., additional, Pantoja, Petraleigh, additional, Hassert, Mariah A., additional, Rodríguez, Idia V., additional, Giavedoni, Luis, additional, Hodara, Vida, additional, Parodi, Laura, additional, Cruz, Lorna, additional, Arana, Teresa, additional, Martínez, Melween I., additional, White, Laura, additional, Brien, James D., additional, de Silva, Aravinda, additional, Pinto, Amelia K., additional, and Sariol, Carlos A., additional
- Published
- 2020
- Full Text
- View/download PDF
50. T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species
- Author
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Grifoni, Alba, primary, Voic, Hannah, additional, Dhanda, Sandeep Kumar, additional, Kidd, Conner K., additional, Brien, James D., additional, Buus, Søren, additional, Stryhn, Anette, additional, Durbin, Anna P., additional, Whitehead, Stephen, additional, Diehl, Sean A., additional, De Silva, Aruna D., additional, Balmaseda, Angel, additional, Harris, Eva, additional, Weiskopf, Daniela, additional, and Sette, Alessandro, additional
- Published
- 2020
- Full Text
- View/download PDF
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