35 results on '"Bright, Chloe J."'
Search Results
2. Errors in determination of net survival: cause-specific and relative survival settings
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Bright, Chloe J., Brentnall, Adam R., Wooldrage, Kate, Myles, Jonathon, Sasieni, Peter, and Duffy, Stephen W.
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- 2020
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3. Risk of subsequent primary neoplasms in survivors of adolescent and young adult cancer (Teenage and Young Adult Cancer Survivor Study): a population-based, cohort study
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Bright, Chloe J, Reulen, Raoul C, Winter, David L, Stark, Daniel P, McCabe, Martin G, Edgar, Angela B, Frobisher, Clare, and Hawkins, Michael M
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- 2019
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4. The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries
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Grabow, Desiree, Kaiser, Melanie, Hjorth, Lars, Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., de Vathaire, Florent, Feijen, Elizabeth A. M., Garwicz, Stanislaw, Hagberg, Oskar, Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Kremer, Leontien C. M., Kuehni, Claudia E., Kuonen, Rahel, Lähteenmäki, Päivi Maria, Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Zaletel, Lorna Zadravec, and Kaatsch, Peter
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- 2018
5. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe
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Fidler, Miranda M., Reulen, Raoul C., Winter, David L., Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Byrne, Julianne, Feijen, Elizabeth A. M., Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kuonen, Rahel, Linge, Helena, Maule, Milena, Merletti, Franco, Øfstaas, Hilde, Ronckers, Cecile M., Skinner, Roderick, Teepen, Jop, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuehni, Claudia E., Winther, Jeanette F., de Vathaire, Florent, Kremer, Leontien C., Hjorth, Lars, and Hawkins, Michael M.
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- 2018
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6. Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study
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Reulen, Raoul C., Bright, Chloe J., Winter, David L., Fidler, Miranda M., Wong, Kwok, Guha, Joyeeta, Kelly, Julie S., Frobisher, Clare, Edgar, Angela B., Skinner, Roderick, Wallace, W. Hamish B., and Hawkins, Mike M.
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- 2017
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7. Palliative chemotherapy for breast cancer: A population‐based cohort study of emergency hospital admissions and place of death
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Bright, Chloe J., primary, Dunlop, Casey, additional, Chen, Cong, additional, Smittenaar, Rebecca, additional, McPhail, Sean, additional, Hanbury, Georgina, additional, Dodwell, David, additional, Pritchard‐Jones, Kathy, additional, Peake, Mick, additional, and Kipps, Emma, additional
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- 2022
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8. Impact of the third national ‘Be Clear on Cancer’ Breast Cancer in Women over 70 Campaign on general practitioner attendance and referral, diagnosis rates and prevalence awareness
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Eberhardt, Judith, primary, Bright, Chloe J., additional, Gildea, Carolyn, additional, Adeghe, Osa, additional, Mak, Vivian, additional, Paley, Lizz, additional, Ling, Jonathan, additional, and Elliss‐Brookes, Lucy, additional
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- 2022
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9. Risk of Cerebrovascular Events in 178 962 Five-Year Survivors of Cancer Diagnosed at 15 to 39 Years of Age: The TYACSS (Teenage and Young Adult Cancer Survivor Study)
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Bright, Chloe J., Hawkins, Mike M., Guha, Joyeeta, Henson, Katherine E., Winter, David L., Kelly, Julie S., Feltbower, Richard G., Hall, Marlous, Cutter, David J., Edgar, Angela B., Frobisher, Clare, and Reulen, Raoul C.
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- 2017
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10. An evaluation of a national mass media campaign to raise public awareness of possible lung cancer symptoms in England in 2016 and 2017
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Ball, Susan, primary, Hyde, Chris, additional, Hamilton, Willie, additional, Bright, Chloe J., additional, Gildea, Carolynn, additional, Wong, Kwok F., additional, Paley, Lizz, additional, Hill, Helen L., additional, Mak, Vivian, additional, Moffat, Jodie, additional, and Elliss-Brookes, Lucy, additional
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- 2021
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11. Abdominal cancer symptoms: Evaluation of the impact of a regional public awareness campaign
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Torrance, Nicola, primary, Bright, Chloe J., additional, Hill, Helen L., additional, Fergusson, Jennie, additional, Kennedy, Catriona, additional, Mak, Vivian, additional, Gildea, Carolynn, additional, Nordin, Andy, additional, and Elliss‐Brookes, Lucy, additional
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- 2021
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12. Reviewing the impact of 11 national Be Clear on Cancer public awareness campaigns, England, 2012 to 2016: A synthesis of published evaluation results
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Lai, Jennifer, primary, Mak, Vivian, additional, Bright, Chloe J., additional, Lyratzopoulos, Georgios, additional, Elliss‐Brookes, Lucy, additional, and Gildea, Carolynn, additional
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- 2020
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13. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study
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Reulen, Raoul C, primary, Wong, Kwok F, additional, Bright, Chloe J, additional, Winter, David L, additional, Alessi, Daniela, additional, Allodji, Rodrigue M, additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Byrne, Julianne, additional, Feijen, Elizabeth AM, additional, Fidler-Benaoudia, Miranda M, additional, Diallo, Ibrahim, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Haddy, Nadia, additional, Høgsholt, Stine, additional, Jankovic, Moncilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kuonen, Rahel, additional, Linge, Helena, additional, Øfstaas, Hilde, additional, Ronckers, Cecile M, additional, Hau, Eva-Maria, additional, Skinner, Roderick, additional, van Leeuwen, Flora E, additional, Teepen, Jop C, additional, Veres, Cristina, additional, Zrafi, Wael, additional, Debiche, Ghazi, additional, Llanas, Damien, additional, Terenziani, Monica, additional, Vu-Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi M, additional, Zadravec Zaletel, Lorna, additional, Kuehni, Claudia E, additional, Winther, Jeanette F, additional, de Vathaire, Florent, additional, Kremer, Leontien C, additional, Hjorth, Lars, additional, and Hawkins, Michael M, additional
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- 2020
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14. Risk of cerebrovascular disease among 13 457 five‐year survivors of childhood cancer: A population‐based cohort study
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Reulen, Raoul C., primary, Guha, Joyeeta, additional, Bright, Chloe J., additional, Henson, Katherine E., additional, Feltbower, Richard G., additional, Hall, Marlous, additional, Kelly, Julie S., additional, Winter, David L., additional, Kwok‐Williams, Michelle, additional, Skinner, Roderick, additional, Cutter, David J., additional, Frobisher, Clare, additional, and Hawkins, Mike M., additional
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- 2020
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15. Corrigendum to: Data Resource Profile: The Systemic Anti-Cancer Therapy (SACT) Dataset
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Bright, Chloe J, primary, Lawton, Sarah, primary, Benson, Stephen, primary, Bomb, Martine, primary, Dodwell, David, primary, Henson, Katherine E, primary, McPhail, Sean, primary, Miller, Louise, primary, Rashbass, Jem, primary, Turnbull, Alice, primary, and Smittenaar, Rebecca, primary
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- 2019
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16. Cardiac Mortality Among 200 000 Five-Year Survivors of Cancer Diagnosed at 15 to 39 Years of Age
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Henson, Katherine E., Reulen, Raoul C., Winter, David L., Bright, Chloe J., Fidler, Miranda M., Frobisher, Clare, Guha, Joyeeta, Wong, Kwok F., Kelly, Julie, Edgar, Angela B., McCabe, Martin G., Whelan, Jeremy, Cutter, David J., Darby, Sarah C., and Hawkins, Mike M.
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Adult ,Male ,heart diseases ,Time Factors ,Adolescent ,neoplasms ,mortality ,Young Adult ,Risk Factors ,Original Research Articles ,cardiac deaths ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Humans ,epidemiology ,Female ,Survivors - Abstract
Supplemental Digital Content is available in the text., Background: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly of cardiac disease that is increased in other cancer populations where cardiotoxic treatments have been used. Methods: The Teenage and Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors of cancer diagnosed at 15 to 39 years of age in England and Wales from 1971 to 2006, and followed to 2014. Standardized mortality ratios, absolute excess risks, and cumulative risks were calculated. Results: Two thousand sixteen survivors died of cardiac disease. For all cancers combined, the standardized mortality ratios for all cardiac diseases combined was greatest for individuals diagnosed at 15 to 19 years of age (4.2; 95% confidence interval, 3.4–5.2) decreasing to 1.2 (95% confidence interval, 1.1–1.3) for individuals aged 35 to 39 years (2P for trend
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- 2016
17. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study.
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Reulen, Raoul C., Wong, Kwok F., Bright, Chloe J., Winter, David L., Alessi, Daniela, Allodji, Rodrigue M., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth A. M., Fidler-Benaoudia, Miranda M., Diallo, Ibrahim, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Høgsholt, Stine, and Jankovic, Moncilo
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CHILDHOOD cancer ,DISEASE risk factors ,COMA ,CANCER survivors ,TESTICULAR cancer ,GALLBLADDER cancer ,MEDICAL sciences - Published
- 2021
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18. Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup
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Allodji, Rodrigue S., primary, Hawkins, Mike M., additional, Bright, Chloe J., additional, Fidler-Benaoudia, Miranda M., additional, Winter, David L., additional, Alessi, Daniela, additional, Fresneau, Brice, additional, Journy, Neige, additional, Morsellino, Vera, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Byrne, Julianne, additional, Feijen, Elizabeth (Lieke) AM., additional, Teepen, Jop C., additional, Vu-Bezin, Giao, additional, Rubino, Carole, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Hau, Eva-Maria, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Linge, Helena, additional, Muraca, Monica, additional, Llanas, Damien, additional, Veres, Cristina, additional, Øfstaas, Hilde, additional, Diallo, Ibrahima, additional, Mansouri, Imene, additional, Ronckers, Cecile M., additional, Skinner, Roderick, additional, Terenziani, Monica, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Winther, Jeanette F., additional, Michel, Gisela, additional, Kremer, Leontien C.M., additional, Hjorth, Lars, additional, Haddy, Nadia, additional, de Vathaire, Florent, additional, and Reulen, Raoul C., additional
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- 2019
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19. Data Resource Profile: The Systemic Anti-Cancer Therapy (SACT) dataset
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Bright, Chloe J, primary, Lawton, Sarah, additional, Benson, Stephen, additional, Bomb, Martine, additional, Dodwell, David, additional, Henson, Katherine E, additional, McPhail, Sean, additional, Miller, Louise, additional, Rashbass, Jem, additional, Turnbull, Alice, additional, and Smittenaar, Rebecca, additional
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- 2019
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20. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, primary, Alessi, Daniela, additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Bright, Chloe J., additional, Brown, Morven, additional, Diallo, Ibrahima, additional, Feijen, Elizabeth A.M. (Lieke), additional, Fidler, Miranda M., additional, Frey, Eva, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Hagberg, Oskar, additional, Harila-Saari, Arja, additional, Hau, Eva M., additional, Haupt, Riccardo, additional, Hawkins, Mike M., additional, Jakab, Zsuzsanna, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kremer, Leontien C.M., additional, Kuehni, Claudia E., additional, Kuonen, Rahel, additional, Ladenstein, Ruth, additional, Lähteenmäki, Päivi Maria, additional, Levitt, Gill, additional, Linge, Helena, additional, LLanas, Damien, additional, Michel, Gisela, additional, Morsellino, Vera, additional, Mulder, Renee L., additional, Reulen, Raoul C., additional, Ronckers, Cécile M., additional, Sacerdote, Carlotta, additional, Skinner, Roderick, additional, Steliarova-Foucher, Eva, additional, van der Pal, Helena J., additional, de Vathaire, Florent, additional, Vũ Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Winter, David L., additional, Winther, Jeanette Falck, additional, Witthoff, Elise, additional, Zadravec Zaletel, Lorna, additional, and Hjorth, Lars, additional
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- 2018
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21. Reviewing the impact of 11 national Be Clear on Cancer public awareness campaigns, England, 2012 to 2016: A synthesis of published evaluation results.
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Lai, Jennifer, Mak, Vivian, Bright, Chloe J., Lyratzopoulos, Georgios, Elliss‐Brookes, Lucy, and Gildea, Carolynn
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GENERAL practitioners ,BREAST cancer ,AWARENESS ,MEDICAL referrals ,HELP-seeking behavior - Abstract
The Be Clear on Cancer (BCoC) campaigns have run in England since 2010. They aim to raise awareness of possible cancer symptoms, encouraging people to consult a general practice with these symptoms. Our study provides an overview of the impact of 11 national campaigns, for bowel, lung, bladder and kidney, breast and oesophago‐gastric cancers. We synthesised existing results for each campaign covering seven clinical metrics across the patient pathway from primary care attendances to one‐year net survival. For each metric, "before" and "after" periods were compared to assess change potentially related to the campaign. Results show that primary care attendances for campaign‐related symptoms increased for 9 of 10 campaigns and relevant urgent referrals for suspected cancer increased above general trends for 9 of 11 campaigns. Diagnostic tests increased for 6 of 11 campaigns. For 7 of 11 campaigns, there were increases in cancer diagnoses resulting from an urgent referral for suspected cancer. There were sustained periods where more cancers were diagnosed than expected for 8 of 10 campaigns, with higher than expected proportions diagnosed at an early stage for sustained periods for 4 of 10 campaigns. There was no impact on survival. In summary, there is evidence that the BCoC campaigns impact help‐seeking by patients and referral patterns by general practitioners, with some impact on diagnosis (incidence and stage). There was no clear evidence of impact on survival. What's new? Starting in 2010, the "Be Clear on Cancer" public awareness campaigns in England have promoted awareness of possible cancer symptoms, encouraging people with these symptoms to seek help without delay. This study is the first to evaluate the impact of 11 national campaigns for bowel, lung, bladder and kidney, breast, and oesophago‐gastric cancers on multiple points of the patient pathway. Evidence shows that the campaigns influence help‐seeking by patients and primary care referral patterns, with some impact on diagnosis (incidence and stage) but no impact on survival. The findings have potential implications for the design and sequencing of future campaigns. [ABSTRACT FROM AUTHOR]
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- 2021
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22. Risk of cerebrovascular disease among 13 457 five‐year survivors of childhood cancer: A population‐based cohort study.
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Reulen, Raoul C., Guha, Joyeeta, Bright, Chloe J., Henson, Katherine E., Feltbower, Richard G., Hall, Marlous, Kelly, Julie S., Winter, David L., Kwok‐Williams, Michelle, Skinner, Roderick, Cutter, David J., Frobisher, Clare, and Hawkins, Mike M.
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CEREBROVASCULAR disease ,SECONDARY primary cancer ,CHILDHOOD cancer ,CANCER survivors ,COHORT analysis ,CENTRAL nervous system ,HOSPITAL statistics - Abstract
Survivors of childhood cancer treated with cranial irradiation are at risk of cerebrovascular disease (CVD), but the risks beyond age 50 are unknown. In all, 13457 survivors of childhood cancer included in the population‐based British Childhood Cancer Survivor Study cohort were linked to Hospital Episode Statistics data for England. Risk of CVD related hospitalisation was quantified by standardised hospitalisation ratios (SHRs), absolute excess risks and cumulative incidence. Overall, 315 (2.3%) survivors had been hospitalised at least once for CVD with a 4‐fold risk compared to that expected (95% confidence interval [CI]: 3.7‐4.3). Survivors of a central nervous system (CNS) tumour and leukaemia treated with cranial irradiation were at greatest risk of CVD (SHR = 15.6, 95% CI: 14.0‐17.4; SHR = 5.4; 95% CI: 4.5‐6.5, respectively). Beyond age 60, on average, 3.1% of CNS tumour survivors treated with cranial irradiation were hospitalised annually for CVD (0.4% general population). Cumulative incidence of CVD increased from 16.0% at age 50 to 26.0% at age 65 (general population: 1.4‐4.2%). In conclusion, among CNS tumour survivors treated with cranial irradiation, the risk of CVD continues to increase substantially beyond age 50 up to at least age 65. Such survivors should be: counselled regarding this risk; regularly monitored for hypertension, dyslipidaemia and diabetes; advised on life‐style risk behaviours. Future research should include the recall for counselling and brain MRI to identify subgroups that could benefit from pharmacological or surgical intervention and establishment of a case‐control study to comprehensively determine risk‐factors for CVD. What's new? Many sub‐groups of childhood‐cancer survivors have an increased risk of developing adverse health conditions later in life. In our study, the authors found that patients who were treated with cranial irradiation in childhood face a substantially greater risk of cerebrovascular disease after age 50. By age 65, as many as 26% of these patients will have been hospitalised for a cerebrovascular event. These survivors should therefore be counselled regarding lifestyle behaviours to reduce this risk. They should also be regularly monitored for hypertension, dyslipidaemia and diabetes. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Respiratory mortality of childhood, adolescent and young adult cancer survivors
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Fidler, Miranda M, primary, Reulen, Raoul C, additional, Bright, Chloe J, additional, Henson, Katherine E, additional, Kelly, Julie S, additional, Jenney, Meriel, additional, Ng, Antony, additional, Whelan, Jeremy, additional, Winter, David L, additional, Frobisher, Clare, additional, and Hawkins, Michael M, additional
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- 2018
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24. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe
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Fidler, Miranda M., primary, Reulen, Raoul C., additional, Winter, David L., additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Bright, Chloe J., additional, Byrne, Julianne, additional, Feijen, Elizabeth A. M., additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Haddy, Nadia, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kuonen, Rahel, additional, Linge, Helena, additional, Maule, Milena, additional, Merletti, Franco, additional, Øfstaas, Hilde, additional, Ronckers, Cecile M., additional, Skinner, Roderick, additional, Teepen, Jop, additional, Terenziani, Monica, additional, Vu-Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Winther, Jeanette F., additional, de Vathaire, Florent, additional, Kremer, Leontien C., additional, Hjorth, Lars, additional, and Hawkins, Michael M., additional
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- 2017
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25. Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.
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Bright, Chloe J., Hawkins, Mike M., Winter, David L., Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth A. M., Fidler, Miranda M., Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, and Kuehni, Claudia E.
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CANCER patients , *CENTRAL nervous system , *NERVOUS system , *AFFERENT pathways , *LEIOMYOSARCOMA , *COMPARATIVE studies , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *SARCOMA , *SOFT tissue tumors , *TIME , *EVALUATION research , *DISEASE incidence , *ACQUISITION of data , *SECONDARY primary cancer - Abstract
Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma.Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers. [ABSTRACT FROM AUTHOR]- Published
- 2018
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26. Corrigendum to: Data Resource Profile: The Systemic Anti-Cancer Therapy (SACT) Dataset.
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Bright, Chloe J, Lawton, Sarah, Benson, Stephen, Bomb, Martine, Dodwell, David, Henson, Katherine E, McPhail, Sean, Miller, Louise, Rashbass, Jem, Turnbull, Alice, and Smittenaar, Rebecca
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INTERNATIONAL agencies - Published
- 2020
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27. Data Resource Profile: The Systemic Anti-Cancer Therapy (SACT) dataset.
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Bright, Chloe J, Lawton, Sarah, Benson, Stephen, Bomb, Martine, Dodwell, David, Henson, Katherine E, McPhail, Sean, Miller, Louise, Rashbass, Jem, Turnbull, Alice, and Smittenaar, Rebecca
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MEDICAL personnel , *T cell receptors , *TUMOR treatment , *THERAPEUTIC use of antineoplastic agents , *RESEARCH , *RESEARCH methodology , *ACQUISITION of data , *EVALUATION research , *MEDICAL cooperation , *TREATMENT effectiveness , *COMPARATIVE studies , *RESEARCH funding - Published
- 2020
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28. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A.M. Lieke, Fidler, Miranda M., Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M., Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C. M., Kuehni, Claudia E., Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, Llanas, Damien, Michel, Gisela (Co-Author), Morsellino, Vera, Mulder, Renee L., Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, van der Pal, Helena J., de Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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Late mortality ,Childhood and adolescent cancer ,Second malignancies ,Survivors ,Guidelines ,Cardiac late effects ,3. Good health - Abstract
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment. PanCareSurFup (PCSF) is the first pan-European project to evaluate some of the serious long-term health risks faced by survivors. This article sets out the overall rationale, methods and preliminary results of PCSF. Methods: The PCSF consortium pooled data from 13 cancer registries and hospitals in 12 European countries to evaluate subsequent primary malignancies, cardiac disease and late mortality in survivors diagnosed between ages 0 and 20 years. In addition, PCSF integrated radiation dosimetry to sites of second malignancies and to the heart, developed evidence-based guidelines for long-term care and for transition services, and disseminated results to survivors and the public. Results: We identified 115,596 individuals diagnosed with cancer, of whom 83,333 were 5-year survivors and diagnosed from 1940 to 2011. This single data set forms the basis for cohort analyses of subsequent malignancies, cardiac disease and late mortality and case–control studies of subsequent malignancies and cardiac disease in 5-year survivors. Conclusions: PCSF delivered specific estimates of risk and comprehensive guidelines to help survivors and care-givers. The expected benefit is to provide every European CCS with improved access to care and better long-term health.
29. Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup
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Allodji, Rodrigue S, Hawkins, Mike M, Bright, Chloe J, Fidler-Benaoudia, Miranda M, Winter, David L, Alessi, Daniela, Fresneau, Brice, Journy, Neige, Morsellino, Vera, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth Lieke Am, Teepen, Jop C, Vu-Bezin, Giao, Rubino, Carole, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Hau, Eva-Maria, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Linge, Helena, Muraca, Monica, Llanas, Damien, Veres, Cristina, Øfstaas, Hilde, Diallo, Ibrahima, Mansouri, Imene, Ronckers, Cecile M, Skinner, Roderick, Terenziani, Monica, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuehni, Claudia E, Winther, Jeanette F, Michel, Gisela, Kremer, Leontien C M, Hjorth, Lars, Haddy, Nadia, De Vathaire, Florent, and Reulen, Raoul C
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
BACKGROUND Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. METHODS This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. RESULTS One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. CONCLUSIONS We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.
30. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J, Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A M Lieke, Fidler, Miranda M, Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M, Haupt, Riccardo, Hawkins, Mike M, Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C M, Kuehni, Claudia E, Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, LLanas, Damien, Michel, Gisela, Morsellino, Vera, Mulder, Renee L, Reulen, Raoul C, Ronckers, Cécile M, Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, Van Der Pal, Helena J, De Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L, Falck Winther, Jeanette, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
BACKGROUND Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment. PanCareSurFup (PCSF) is the first pan-European project to evaluate some of the serious long-term health risks faced by survivors. This article sets out the overall rationale, methods and preliminary results of PCSF. METHODS The PCSF consortium pooled data from 13 cancer registries and hospitals in 12 European countries to evaluate subsequent primary malignancies, cardiac disease and late mortality in survivors diagnosed between ages 0 and 20 years. In addition, PCSF integrated radiation dosimetry to sites of second malignancies and to the heart, developed evidence-based guidelines for long-term care and for transition services, and disseminated results to survivors and the public. RESULTS We identified 115,596 individuals diagnosed with cancer, of whom 83,333 were 5-year survivors and diagnosed from 1940 to 2011. This single data set forms the basis for cohort analyses of subsequent malignancies, cardiac disease and late mortality and case-control studies of subsequent malignancies and cardiac disease in 5-year survivors. CONCLUSIONS PCSF delivered specific estimates of risk and comprehensive guidelines to help survivors and care-givers. The expected benefit is to provide every European CCS with improved access to care and better long-term health.
31. The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries
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Grabow, Desiree, Kaiser, Melanie, Hjorth, Lars, Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J, De Vathaire, Florent, Feijen, Elizabeth A M, Garwicz, Stanislaw, Hagberg, Oskar, Haupt, Riccardo, Hawkins, Mike M, Jakab, Zsuzsanna, Kremer, Leontien C M, Kuehni, Claudia E, Kuonen, Rahel, Lähteenmäki, Päivi Maria, Reulen, Raoul C, Ronckers, Cécile M, Sacerdote, Carlotta, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L, Winther, Jeanette Falck, Zaletel, Lorna Zadravec, and Kaatsch, Peter
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from 12 countries delivered data to the data centre in Mainz. Data providers used a single variable list that covered all three outcomes. After validity and plausibility checks data was provided to the outcome-specific working groups. In total, we collected data on 115,596 patients diagnosed with cancer from 1940 to 2011, of whom 83,333 had survived 5 years or more. Due to the eligibility criteria and other requirements different numbers of survivors were eligible for the analysis of each of the outcomes. Thus, 1014 patients with at least one cardiac event were identified from a cohort of 39,152 5-year survivors; for second cancers 3995 survivors developed at least one second cancer from a cohort of 71,494 individuals, and from the late mortality cohort of 79,441 who had survived at least 5 years, 9247 died subsequently. Through the close cooperation of many European countries and the establishment of one central data collection and harmonising centre, the project succeeded in generating the largest cohort of children with cancer to date.
32. Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe
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Bright, Chloe J, Hawkins, Mike M, Winter, David L, Alessi, Daniela, Allodji, Rodrigue S, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth A M, Fidler, Miranda M, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kuehni, Claudia E, Linge, Helena, Øfstaas, Hilde, Ronckers, Cecile M, Skinner, Roderick, Teepen, Jop C, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuonen, Rahel, Winther, Jeanette F, De Vathaire, Florent, Kremer, Leontien C, Hjorth, Lars, and Reulen, Raoul C
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
Background Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer. Methods We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma. Conclusions For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers.
33. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A.M. Lieke, Fidler, Miranda M., Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M., Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C. M., Kuehni, Claudia E., Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, Llanas, Damien, Michel, Gisela (Co-Author), Morsellino, Vera, Mulder, Renee L., Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, van der Pal, Helena J., de Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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Late mortality ,Childhood and adolescent cancer ,Second malignancies ,Survivors ,Guidelines ,Cardiac late effects ,3. Good health - Abstract
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment. PanCareSurFup (PCSF) is the first pan-European project to evaluate some of the serious long-term health risks faced by survivors. This article sets out the overall rationale, methods and preliminary results of PCSF. Methods: The PCSF consortium pooled data from 13 cancer registries and hospitals in 12 European countries to evaluate subsequent primary malignancies, cardiac disease and late mortality in survivors diagnosed between ages 0 and 20 years. In addition, PCSF integrated radiation dosimetry to sites of second malignancies and to the heart, developed evidence-based guidelines for long-term care and for transition services, and disseminated results to survivors and the public. Results: We identified 115,596 individuals diagnosed with cancer, of whom 83,333 were 5-year survivors and diagnosed from 1940 to 2011. This single data set forms the basis for cohort analyses of subsequent malignancies, cardiac disease and late mortality and case–control studies of subsequent malignancies and cardiac disease in 5-year survivors. Conclusions: PCSF delivered specific estimates of risk and comprehensive guidelines to help survivors and care-givers. The expected benefit is to provide every European CCS with improved access to care and better long-term health., + ID der Publikation: unilu_35424 + Sprache: Englisch + Letzte Aktualisierung: 2018-12-18 11:58:12
34. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe.
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Fidler MM, Reulen RC, Winter DL, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Bright CJ, Byrne J, Feijen EAM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuonen R, Linge H, Maule M, Merletti F, Øfstaas H, Ronckers CM, Skinner R, Teepen J, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuehni CE, Winther JF, de Vathaire F, Kremer LC, Hjorth L, and Hawkins MM
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- Adolescent, Adult, Child, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Humans, Male, Osteosarcoma epidemiology, Retinoblastoma epidemiology, Sarcoma epidemiology, Young Adult, Bone Neoplasms epidemiology, Neoplasms, Second Primary epidemiology, Survivors statistics & numerical data
- Abstract
Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors., Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided., Results: Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk., Conclusions: For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer., (© The Author 2017. Published by Oxford University Press.)
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- 2018
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35. Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study.
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Reulen RC, Bright CJ, Winter DL, Fidler MM, Wong K, Guha J, Kelly JS, Frobisher C, Edgar AB, Skinner R, Wallace WHB, and Hawkins MM
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- Anemia epidemiology, Anemia etiology, Diabetes Mellitus epidemiology, Diabetes Mellitus etiology, England, Female, Humans, Hypertension epidemiology, Hypertension etiology, Kidney Neoplasms radiotherapy, Pregnancy, Wilms Tumor radiotherapy, Obstetric Labor Complications epidemiology, Obstetric Labor Complications etiology, Pregnancy Complications epidemiology, Pregnancy Complications etiology, Radiotherapy adverse effects, Survivors statistics & numerical data
- Abstract
Background: Female survivors of childhood cancer treated with abdominal radiotherapy who manage to conceive are at risk of delivering premature and low-birthweight offspring, but little is known about whether abdominal radiotherapy may also be associated with additional complications during pregnancy and labor. We investigated the risk of developing pregnancy and labor complications among female survivors of childhood cancer in the British Childhood Cancer Survivor Study (BCCSS)., Methods: Pregnancy and labor complications were identified by linking the BCCSS cohort (n = 17 980) to the Hospital Episode Statistics (HES) for England. Relative risks (RRs) of pregnancy and labor complications were calculated by site of radiotherapy treatment (none/abdominal/cranial/other) and other cancer-related factors using log-binomial regression. All statistical tests were two-sided., Results: A total of 2783 singleton pregnancies among 1712 female survivors of childhood cancer were identified in HES. Wilms tumor survivors treated with abdominal radiotherapy were at threefold risk of hypertension complicating pregnancy (relative risk = 3.29, 95% confidence interval [CI] = 2.29 to 4.71), while all survivors treated with abdominal radiotherapy were at risk of gestational diabetes mellitus (RR = 3.35, 95% CI = 1.41 to 7.93) and anemia complicating pregnancy (RR = 2.10, 95% CI = 1.27 to 3.46) compared with survivors treated without radiotherapy. Survivors treated without radiotherapy had similar risks of pregnancy and labor complications as the general population, except survivors were more likely to opt for an elective cesarean section (RR = 1.39, 95% CI = 1.16 to 1.70)., Conclusions: Treatment with abdominal radiotherapy increases the risk of developing hypertension complicating pregnancy in Wilms tumor survivors, and diabetes mellitus and anemia complicating pregnancy in all survivors. These patients may require extra vigilance during pregnancy., (© The Author 2017. Published by Oxford University Press.)
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- 2017
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