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13 results on '"Bringué, Josep"'

2. Nebulized Amikacin and Fosfomycin for Severe Pseudomonas aeruginosa Pneumonia: An Experimental Study*

Author

Li Bassi, Gianluigi, Motos, Ana, Fernandez-Barat, Laia, Aguilera Xiol, Eli, Chiurazzi, Chiara, Senussi, Tarek, Saco, Maria A., Fuster, Carla, Carbonara, Marco, Bobi, Joaquim, Amaro, Rosanel, De Rosa, Francesca, Comaru, Talitha, Yang, Hua, Ranzani, Otavio T., Marti, Joan-Daniel, Rinaudo, Mariano, Comino Trinidad, Oscar, Rigol, Montserrat, Bringué, Josep, Ramirez, Jose, Nicolau, David P., Pelosi, Paolo, Antonelli, Massimo, Blasi, Francesco, Artigas, Antonio, Montgomery, A. Bruce, and Torres, Antoni

Published
2019
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5. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

Author

Morales-Quinteros, Luis, Schultz, Marcus J., Bringué, Josep, Calfee, Carolyn S., Camprubí, Marta, Cremer, Olaf L., Horn, Janneke, van der Poll, Tom, Sinha, Pratik, Artigas, Antonio, Bos, Lieuwe D., de Beer, Friso M., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T., Huson, Mischa A., Scicluna, Brendon, Schouten, Laura R., Straat, Marleen, van Vught, Lonneke A., Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Varkila, Meri R., Verboom, Diana M., Intensive Care Medicine, ANS - Neuroinfection & -inflammation, Center of Experimental and Molecular Medicine, Infectious diseases, ACS - Heart failure & arrhythmias, Anesthesiology, Graduate School, ACS - Diabetes & metabolism, APH - Quality of Care, Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, ARD - Amsterdam Reproduction and Development, ACS - Pulmonary hypertension & thrombosis, and ACS - Microcirculation

Subjects
medicine.medical_specialty, ARDS, medicine.medical_treatment, Dead space, Respiratory Dead Space, Prognostication, Critical Care and Intensive Care Medicine, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Journal Article, medicine, Acute respiratory distress syndrome (ARDS), Intensive care unit, Mortality, Respiratory dead space, Mechanical ventilation, Acute respiratory distress syndrome, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Ventilatory ratio, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Odds ratio, medicine.disease, 030228 respiratory system, Breathing, Cardiology, Prediction, business, Cohort study
Abstract

Background Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This study aimed to compare various methods for dead space estimation and the ventilatory ratio in patients with acute respiratory distress syndrome (ARDS) and to determine their independent values for predicting death at day 30. The present study is a post hoc analysis of a prospective observational cohort study of ICUs of two tertiary care hospitals in the Netherlands. Results Individual patient data from 940 ARDS patients were analyzed. Estimated dead space fraction and the ventilatory ratio at days 1 and 2 were significantly higher among non-survivors (p VD/VT phys] and the ventilatory ratio at day 2 showed independent association with mortality at 30 days (odds ratio 1.28 [95% CI 1.02–1.61], p p VD/VT HB] and Penn State [VD/VT PS] estimations were not associated with mortality. The predicted validity of the estimated dead space fraction and the ventilatory ratio improved the baseline model based on PEEP, PaO2/FiO2, driving pressure and compliance of the respiratory system at day 2 (AUROCC 0.72 vs. 0.69, p Conclusions Estimated methods for dead space calculation and the ventilatory ratio during the early course of ARDS are associated with mortality at day 30 and add statistically significant but limited improvement in the predictive accuracy to indices of oxygenation and respiratory system mechanics at the second day of mechanical ventilation.

Published
2019
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6. MOESM1 of Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

Author

Morales-Quinteros, Luis, Schultz, Marcus, Bringué, Josep, Calfee, Carolyn, Camprubí, Marta, Cremer, Olaf, Horn, Janneke, Poll, Tom, Pratik Sinha, Artigas, Antonio, and Bos, Lieuwe

Subjects
respiratory system, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Additional file 1. Estimated dead space fraction (Harris-Benedict estimate) showing the association between VD/VT separated in tertiles (left: 0.68) and mortality according to tertiles of PaO2/FiO2 (upper row), PEEP (second row), driving pressure (third row) and compliance of the respiratory system (bottom row).

Published
2019
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7. Role of hypercapnia in LPS injured human primary alveolar cells

Author

Camprubí-Rimblas, Marta, primary, Bringué, Josep, additional, Morales-Quinteros, Luís, additional, Tantinyà, Neus, additional, Farré, Ramon, additional, Almendros, Isaac, additional, Fiblà, Juan José, additional, Saumench, Roser, additional, and Artigas, Antonio, additional

Published
2019
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