641 results on '"Briot P"'
Search Results
2. miditok: A Python package for MIDI file tokenization
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Fradet, Nathan, Briot, Jean-Pierre, Chhel, Fabien, Seghrouchni, Amal El Fallah, and Gutowski, Nicolas
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Computer Science - Machine Learning - Abstract
Recent progress in natural language processing has been adapted to the symbolic music modality. Language models, such as Transformers, have been used with symbolic music for a variety of tasks among which music generation, modeling or transcription, with state-of-the-art performances. These models are beginning to be used in production products. To encode and decode music for the backbone model, they need to rely on tokenizers, whose role is to serialize music into sequences of distinct elements called tokens. MidiTok is an open-source library allowing to tokenize symbolic music with great flexibility and extended features. It features the most popular music tokenizations, under a unified API. It is made to be easily used and extensible for everyone., Comment: Updated and comprehensive report. Original ISMIR 2021 document at https://archives.ismir.net/ismir2021/latebreaking/000005.pdf
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- 2023
3. Impact of time and note duration tokenizations on deep learning symbolic music modeling
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Fradet, Nathan, Gutowski, Nicolas, Chhel, Fabien, and Briot, Jean-Pierre
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Computer Science - Sound ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Symbolic music is widely used in various deep learning tasks, including generation, transcription, synthesis, and Music Information Retrieval (MIR). It is mostly employed with discrete models like Transformers, which require music to be tokenized, i.e., formatted into sequences of distinct elements called tokens. Tokenization can be performed in different ways. As Transformer can struggle at reasoning, but capture more easily explicit information, it is important to study how the way the information is represented for such model impact their performances. In this work, we analyze the common tokenization methods and experiment with time and note duration representations. We compare the performances of these two impactful criteria on several tasks, including composer and emotion classification, music generation, and sequence representation learning. We demonstrate that explicit information leads to better results depending on the task., Comment: ISMIR 2023
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- 2023
4. Increasing Civil Society Ownership of National Climate Plans: Lessons drawn from Senegal's NDC experience
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Briot, Estelle and Alice Leroy de Altai Consulting
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Climate change ,Governance and citizenship ,Changement climatique ,Gouvernance et citoyenneté - Abstract
The issue of civil society participation in the processes of developing, implementing, and monitoring national climate plans is crucial to ensuring that these ambitions are both acceptable to the populations and, beyond that, that they align with a trajectory of sustainable development beneficial to all actors in Senegalese society. This case study aims to analyze the degree of involvement through consultations with a variety of civil society actors, as well as members of the administration and international partners active in the fight against climate change. While some believe that civil society participation has progressed significantly in recent years, the vast majority feel that the level reached is still insufficient., Barriers to civil society’s appropriation of climate issues include, among others, the lack of representativeness of grassroots organizations and vulnerable groups, as well as the unfamiliarity of civil society organizations (CSOs) and community-based organizations (CBOs) with the processes, objectives, and stakeholders of the National Climate Plan (NCP), meaning that many civil society actors are rarely aware of their contribution to its implementation even though they are involved. The study also shows how limited human and financial resources reduce the possibility of broad participation by civil society organizations, especially outside the capital. This raises the question of a fair, adequate, and targeted allocation of climate financing to meet the ambitions of climate policies in Senegal. This report presents recommendations to overcome barriers that may explain low ownership of national climate plans by communities, in order to propose ways for populations to be key actors in an ambitious ecological transition in Senegal., La question de la participation de la société civile aux processus d’élaboration, de mise en oeuvre et de suivi des plans nationaux sur le climat est clé afin de s’assurer que ces ambitions soient à la fois acceptables pour les populations et, au-delà, qu’elles s’inscrivent dans une trajectoire de développement durable bénéfique à l’ensemble des acteurs de la société sénégalaise., Cette étude de cas vise à analyser ce degré d’implication, à travers des consultations menées auprès d’une variété d’acteurs de la société civile, ainsi que des membres de l’administration et des partenaires internationaux actifs dans la lutte contre les changements climatiques. Alors que certains estiment que la participation de la société civile a beaucoup progressé dans les dernières années, la large majorité juge que le niveau atteint est encore insuffisant., Les barrières à l’appropriation des enjeux climatiques par la société civile incluent, entre autres, le manque de représentativité des organisations communautaires de base et des groupes vulnérables, mais également la méconnaissance des processus, objectifs et interlocuteurs de la CDN de la part des OSC et des OCB, impliquant que de nombreux acteurs de la société civile sont rarement conscients de contribuer à sa mise en oeuvre même si cela est le cas., L’étude montre également comment des ressources humaines et financières limitées réduisent la possibilité d’une large participation des organisations de la société civile, en particulier en dehors de la capitale. Cela soulève la question d’une allocation juste, adéquate et ciblée des financements climatiques pour répondre aux ambitions des politiques climatiques au Sénégal. Ce rapport présente des recommandations afin de surmonter les barrières qui expliqueraient une faible appropriation des plans nationaux sur le climat par les communautés, afin de proposer des voies pour que les populations soient des acteurs au coeur d’une transition écologique ambitieuse au Sénégal.
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- 2024
5. Correction: Creating a health informatics data resource for hearing health research
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Mehta, Nishchay, Ribeyre, Baptiste Briot, Dimitrov, Lilia, English, Louise J., Ewart, Colleen, Heinrich, Antje, Joshi, Nikhil, Munro, Kevin J., Roadknight, Gail, Romao, Luis, Schilder, Anne Gm, Spriggs, Ruth V., Norris, Ruth, Ross, Talisa, and Tilston, George
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- 2024
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6. Recommendations for the optimal use of bone forming agents in osteoporosis
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Veronese, Nicola, Briot, Karine, Guañabens, Nuria, Albergaria, Ben Hur, Alokail, Majed, Al-Daghri, Nasser, Bemden, Angie Botto-van, Bruyère, Olivier, Burlet, Nansa, Cooper, Cyrus, Curtis, Elizabeth M., Ebeling, Peter R., Halbout, Philippe, Hesse, Eric, Hiligsmann, Mickaël, Camargos, Bruno Muzzi, Harvey, Nicholas C., Perez, Adolfo Diez, Radermecker, Régis Pierre, Reginster, Jean-Yves, Rizzoli, René, Siggelkow, Heide, Cortet, Bernard, and Brandi, Maria Luisa
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- 2024
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7. Creating a health informatics data resource for hearing health research
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Mehta, Nishchay, Ribeyre, Baptiste Briot, Dimitrov, Lilia, English, Louise J., Ewart, Colleen, Heinrich, Antje, Joshi, Nikhil, Munro, Kevin J., Roadknight, Gail, Romao, Luis, Schilder, Anne Gm, Spriggs, Ruth V., Norris, Ruth, Ross, Talisa, and Tilston, George
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- 2024
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8. Successful Burosumab Treatment in an Adult Patient with X-Linked Hypophosphatemia and Chronic Kidney Disease Stage 3b
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Michon-Colin, Arthur, Bouderlique, Elise, Prié, Dominique, Maruani, Gérard, Nevoux, Jérôme, Briot, Karine, and Courbebaisse, Marie
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- 2024
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9. ACACIA Project – Development of a Post-Combustion CO2 Capture Process. Case of the DMXTM Process
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Gomez A., Briot P., Raynal L., Broutin P., Gimenez M., Soazic M., Cessat P., and Saysset S.
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Chemical technology ,TP1-1185 ,Energy industries. Energy policy. Fuel trade ,HD9502-9502.5 - Abstract
The objective of the ACACIA project was to develop processes for post-combustion CO2 capture at a lower cost and with a higher energetic efficiency than first generation processes using amines such as MonoEthanolAmine (MEA) which are now considered for the first Carbon Capture and Storage (CCS) demonstrators. The partners involved in this project were: Rhodia (Solvay since then), Arkema, Lafarge, GDF SUEZ, Veolia Environnement, IFP Energies nouvelles, IRCE Lyon, LMOPS, LTIM, LSA Armines. To validate the relevance of the breakthrough processes studied in this project, techno-economic evaluations were carried out with comparison to the reference process using a 30 wt% MEA solvent. These evaluation studies involved all the industrial partners of the project, each partner bringing specific cases of CO2 capture on their industrial facilities. From these studies, only the process using demixing solvent, DMXTM, developed by IFPEN appears as an alternative solution to the MEA process.
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- 2014
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10. Diabetes self-management education improves quality of care and clinical outcomes determined by a diabetes bundle measure
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Brunisholz KD, Briot P, Hamilton S, Joy EA, Lomax M, Barton N, Cunningham R, Savitz LA, and Cannon W
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Medicine (General) ,R5-920 - Abstract
Kimberly D Brunisholz,1,2,* Pascal Briot,1,2,* Sharon Hamilton,1 Elizabeth A Joy,3 Michael Lomax,2 Nathan Barton,2 Ruthann Cunningham,3 Lucy A Savitz,2 Wayne Cannon1 1Primary Care Clinical Program, Intermountain Healthcare, Salt Lake City, UT, USA; 2Institute for Healthcare Delivery, Intermountain Healthcare, Salt Lake City, UT, USA; 3Office of Research, Intermountain Healthcare, Salt Lake City, UT, USA*Joint first authors Purpose: The purpose of this study was to determine the impact of diabetes self-management education (DSME) in improving processes and outcomes of diabetes care as measured by a five component diabetes bundle and HbA1c, in individuals with type 2 diabetes mellitus (T2DM). Methods: A retrospective analysis was performed for adult T2DM patients who received DSME training in 2011–2012 from an accredited American Diabetes Association center at Intermountain Healthcare (IH) and had an HbA1c measurement within the prior 3 months and 2–6 months after completing their first DSME visit. Control patients were selected from the same clinics as case-patients using random number generator to achieve a 1 to 4 ratio. Case and control patients were included if 1) pre-education HbA1c was between 6.0%–14.0%; 2) their main provider was a primary care physician; 3) they met the national Healthcare Effectiveness Data and Information Set criteria for inclusion in the IH diabetes registry. The IH diabetes bundle includes retinal eye exam, nephropathy screening or prescription of angiotensin converting enzyme or angiotensin receptor blocker; blood pressure
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- 2014
11. Creating a health informatics data resource for hearing health research
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Nishchay Mehta, Baptiste Briot Ribeyre, Lilia Dimitrov, Louise J. English, Colleen Ewart, Antje Heinrich, Nikhil Joshi, Kevin J. Munro, Gail Roadknight, Luis Romao, Anne Gm Schilder, Ruth V. Spriggs, Ruth Norris, Talisa Ross, and George Tilston
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Database ,Data sharing ,Hearing health ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background The National Institute of Health and Social Care Research (NIHR) Health Informatics Collaborative (HIC) for Hearing Health has been established in the UK to curate routinely collected hearing health data to address research questions. This study defines priority research areas, outlines its aims, governance structure and demonstrates how hearing health data have been integrated into a common data model using pure tone audiometry (PTA) as a case study. Methods After identifying key research aims in hearing health, the governance structure for the NIHR HIC for Hearing Health is described. The Observational Medical Outcomes Partnership (OMOP) was chosen as our common data model to provide a case study example. Results The NIHR HIC Hearing Health theme have developed a data architecture outlying the flow of data from all of the various siloed electronic patient record systems to allow the effective linkage of data from electronic patient record systems to research systems. Using PTAs as an example, OMOPification of hearing health data successfully collated a rich breadth of datapoints across multiple centres. Conclusion This study identified priority research areas where routinely collected hearing health data could be useful. It demonstrates integration and standardisation of such data into a common data model from multiple centres. By describing the process of data sharing across the HIC, we hope to invite more centres to contribute and utilise data to address research questions in hearing health. This national initiative has the power to transform UK hearing research and hearing care using routinely collected clinical data.
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- 2024
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12. Byte Pair Encoding for Symbolic Music
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Fradet, Nathan, Gutowski, Nicolas, Chhel, Fabien, and Briot, Jean-Pierre
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
When used with deep learning, the symbolic music modality is often coupled with language model architectures. To do so, the music needs to be tokenized, i.e. converted into a sequence of discrete tokens. This can be achieved by different approaches, as music can be composed of simultaneous tracks, of simultaneous notes with several attributes. Until now, the proposed tokenizations rely on small vocabularies of tokens describing the note attributes and time events, resulting in fairly long token sequences, and a sub-optimal use of the embedding space of language models. Recent research has put efforts on reducing the overall sequence length by merging embeddings or combining tokens. In this paper, we show that Byte Pair Encoding, a compression technique widely used for natural language, significantly decreases the sequence length while increasing the vocabulary size. By doing so, we leverage the embedding capabilities of such models with more expressive tokens, resulting in both better results and faster inference in generation and classification tasks. The source code is shared on Github, along with a companion website. Finally, BPE is directly implemented in MidiTok, allowing the reader to easily benefit from this method., Comment: EMNLP 2023, source code: https://github.com/Natooz/BPE-Symbolic-Music
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- 2023
13. Commission Femmes et Astronomie de la SF2A: Women participation in French astronomy
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Ouazzani, Rhita-Maria, Bot, Caroline, Brau-Nogué, Sylvie, Briot, Danielle, de Laverny, Patrick, Lagarde, Nadège, Nesvadba, Nicole, Malzac, Julien, Vauglin, Isabelle, and Venot, Olivia
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Commission Femmes et Astronomie conducted a statistical study that aims at mapping the presence of women in French professional Astronomy today, and set a starting point for studying its evolution with time. For the year 2021, we proceeded with a sub-set of 8 astronomy and astrophysics institutes, hosting a total of 1060 employees, among which PhD students, post-doctoral researchers, and academic, technical, and administrative staff, representing around 25% of the community. We have investigated how the percentage of women vary with career stage, level of responsibility, job security, and level of income. The results of this preliminary study seem to illustrate the leaky pipeline, with one major bottleneck being the access to permanent positions. It appears that the proportion of women steadily decreases with the security of jobs, with the career stage, with the qualification level and with the income level., Comment: 6 pages, 5 figures
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- 2023
14. Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism
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Gonnelli, S., Briot, K., Cormier, C., Teboul, S., Roux, C., and Koumakis, E.
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- 2024
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15. Instance-Aware Observer Network for Out-of-Distribution Object Segmentation
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Besnier, Victor, Bursuc, Andrei, Picard, David, and Briot, Alexandre
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Recent works on predictive uncertainty estimation have shown promising results on Out-Of-Distribution (OOD) detection for semantic segmentation. However, these methods struggle to precisely locate the point of interest in the image, i.e, the anomaly. This limitation is due to the difficulty of finegrained prediction at the pixel level. To address this issue, we build upon the recent ObsNet approach by providing object instance knowledge to the observer. We extend ObsNet by harnessing an instance-wise mask prediction. We use an additional, class agnostic, object detector to filter and aggregate observer predictions. Finally, we predict an unique anomaly score for each instance in the image. We show that our proposed method accurately disentangles in-distribution objects from OOD objects on three datasets.
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- 2022
16. An adaptive music generation architecture for games based on the deep learning Transformer mode
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Santos, Gustavo Amaral Costa dos, Baffa, Augusto, Briot, Jean-Pierre, Feijó, Bruno, and Furtado, Antonio Luz
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Computer Science - Sound ,Computer Science - Machine Learning ,Computer Science - Multimedia ,Electrical Engineering and Systems Science - Audio and Speech Processing ,OOA65, 91A18, 68T07 ,J.5 - Abstract
This paper presents an architecture for generating music for video games based on the Transformer deep learning model. Our motivation is to be able to customize the generation according to the taste of the player, who can select a corpus of training examples, corresponding to his preferred musical style. The system generates various musical layers, following the standard layering strategy currently used by composers designing video game music. To adapt the music generated to the game play and to the player(s) situation, we are using an arousal-valence model of emotions, in order to control the selection of musical layers. We discuss current limitations and prospects for the future, such as collaborative and interactive control of the musical components.
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- 2022
17. High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture
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Kevin Chevalier, Sabrina Hamroun, Samuel Bitoun, Julien Henry, Christian Roux, Karine Briot, Rakiba Belkhir, Xavier Mariette, and Raphaèle Seror
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Osteoporosis ,Smoldering myeloma ,Vertebral fracture ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Multiple myeloma (MM) frequently causes vertebral fractures (VF). Some are lytic lesions and others have the aspect of benign osteoporotic fractures not requiring anti-myeloma treatment. We explored outcome of these patients with smoldering myeloma (SM) and osteoporotic VF.In this retrospective bi-centric study, patients were identified using a systematic keyword search on electronic medical records. Patients with SM and isolated VF of osteoporotic aspect without indications for myeloma-specific therapy were included.Overall, 13 (7 %) of the 184 identified patients had SM and VF confirmed to be osteoporotic (median number of VF was 3). During follow-up, 12 (92 %) patients evolved to symptomatic MM, 7 (54 %) of them within 18 months (early progressors). Myeloma defining events were new lytic bone lesions in 7 patients (53.8 %). The serum calcium level was significantly higher in the early progressor group (median 2.35 IQR [2.31–2.38] and 2.28 IQR [2.21–2.29] respectively, p = 0.003). Early progressors had a higher number of VF at diagnosis (3.0 [2.0–5.5] vs 1.0 [1.0–2.5], p = 0.18) and more frequently evolved to symptomatic MM because of lytic bone lesions (5 [71 %] vs 2 [33 %], p = 0.13) compared to late progressors.VF of osteoporotic appearance in the context of SM is a rare situation but at high risk of rapid progression to symptomatic MM, suggesting that they may represent bone fragility linked to MM infiltration rather than solely osteoporotic fractures. Further studies are needed to assess if earlier treatment might be beneficial in this population.
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- 2024
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18. Recommendations on training objectives and staff qualification for the manual preparation of capsules in pharmacy
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Marçon Frédéric, Lagarce Frédéric, Roland Isabelle, Brossard Denis, Merienne Camille, Chennell Philip, d’Huart Elise, Briot Thomas, Carrez Laurent, Podilsky Gregory, Rohrbach Pascal, Lannoy Damien, Storme Thomas, Guerrault-Moro Marie Noelle, Soulairol Ian, and Crauste-Manciet Sylvie
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education ,continuous learning ,drug compounding ,pharmaceutical technology ,capsules ,Therapeutics. Pharmacology ,RM1-950 ,Pharmaceutical industry ,HD9665-9675 - Abstract
Training and certification of personnel in capsule preparation are essential procedures, overseen by the pharmacist who delegates these tasks. These procedures aim not only to ensure the efficacy and safety of operations but also to establish a clear chain of responsibility. They align with established best practices. Certification grants formal authorization to qualified individuals to perform specific tasks. For new hires, a comprehensive training program is designed to facilitate their integration and empower them from the onset. We propose training objectives structured around a competency-based approach, highlighting objective evaluation criteria applicable in real-world practical settings. These training objectives address critical aspects such as the handling of hazardous substances, weighing and mixing of powders, and capsule filling. They also emphasize the importance of documentation and traceability. Specialized preparations and tools are offered to facilitate the assessment of learning outcomes.
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- 2024
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19. Pathologic complete response and survival in HER2-low and HER2-zero early breast cancer treated with neoadjuvant chemotherapy
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Ilie, Silvia Mihaela, Briot, Nathalie, Constantin, Guillaume, Roussot, Nicolas, Ilie, Alis, Bergeron, Anthony, Arnould, Laurent, Beltjens, Françoise, Desmoulin, Isabelle, Mayeur, Didier, Kaderbhai, Courèche, Hennequin, Audrey, Jankowski, Clémentine, Padeano, Marie Martine, Costaz, Helène, Amet, Alix, Coutant, Charles, Coudert, Bruno, Bertaut, Aurélie, and Ladoire, Sylvain
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- 2023
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20. From Procedures, Objects, Actors, Components, Services, to Agents -- A Comparative Analysis of the History and Evolution of Programming Abstractions
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Briot, Jean-Pierre
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Computer Science - Software Engineering ,Computer Science - Artificial Intelligence ,Computer Science - Programming Languages ,97P40 ,D.3 - Abstract
The objective of this chapter is to propose some retrospective analysis of the evolution of programming abstractions, from {\em procedures}, {\em objects}, {\em actors}, {\em components}, {\em services}, up to {\em agents}, %have some compare concepts of software component and of agent (and multi-agent system), %The method chosen is to by replacing them within a general historical perspective. Some common referential with three axes/dimensions is chosen: {\em action selection} at the level of one entity, {\em coupling flexibility} between entities, and {\em abstraction level}. We indeed may observe some continuous quest for higher flexibility (through notions such as {\em late binding}, or {\em reification} of {\em connections}) and higher level of {\em abstraction}. Concepts of components, services and agents have some common objectives (notably, {\em software modularity and reconfigurability}), with multi-agent systems raising further concepts of {\em autonomy} and {\em coordination}. notably through the notion of {\em auto-organization} and the use of {\em knowledge}. We hope that this analysis helps at highlighting some of the basic forces motivating the progress of programming abstractions and therefore that it may provide some seeds for the reflection about future programming abstractions., Comment: This preprint has been published as a chapter of a book about the French school of programming, coordinated by Bertrand Meyer and published by Springer in 2024
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- 2021
21. The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data
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Ariceta, Gema, Beck-Nielsen, Signe Sparre, Boot, Annemieke M., Brandi, Maria Luisa, Briot, Karine, de Lucas Collantes, Carmen, Emma, Francesco, Giannini, Sandro, Haffner, Dieter, Keen, Richard, Levtchenko, Elena, Mӓkitie, Outi, Mughal, M. Zulf, Nilsson, Ola, Schnabel, Dirk, Tripto-Shkolnik, Liana, Liu, Jonathan, Williams, Angela, Wood, Sue, and Zillikens, M. Carola
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- 2023
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22. Down-regulation of peptidylarginine deiminase type 1 in reconstructed human epidermis disturbs nucleophagy in the granular layer and affects barrier function
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Alioli, Adebayo Candide, Briot, Julie, Pons, Carole, Yang, Hang, Gairin, Marie, Goudounèche, Dominique, Cau, Laura, Simon, Michel, and Méchin, Marie-Claire
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- 2023
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23. Real-world non-interventional post-authorization safety study of long-term use of burosumab in children and adolescents with X-linked hypophosphatemia: first interim analysis
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Annemieke M. Boot, Gema Ariceta, Signe Sparre Beck-Nielsen, Maria Luisa Brandi, Karine Briot, Carmen de Lucas Collantes, Sandro Giannini, Dieter Haffner, Richard Keen, Elena Levtchenko, M. Zulf Mughal, Outi Mӓkitie, Ola Nilsson, Dirk Schnabel, Liana Tripto-Shkolnik, M. Carola Zillikens, Jonathan Liu, Alina Tudor, and Francesco Emma
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Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: X-linked hypophosphatemia (XLH) is a rare, progressive disorder characterized by excess fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D synthesis. Burosumab is a recombinant human monoclonal antibody that inhibits FGF23, restoring patient serum phosphate levels. Safety data on long-term burosumab treatment are currently limited. Objectives: This post-authorization safety study (PASS) aims to monitor long-term safety outcomes in children and adolescents (1–17 years) treated with burosumab for XLH. This first interim analysis reports the initial PASS safety outcomes. Design: A 10-year retrospective and prospective cohort study. Methods: This PASS utilizes International XLH Registry (NCT03193476) data, which includes standard diagnostic and monitoring practice data at participating European centers. Results: At data cut-off (13 May 2021), 647 participants were included in the International XLH Registry; 367 were receiving burosumab, of which 67 provided consent to be included in the PASS. Mean (SD) follow-up time was 2.2 (1.0) years. Mean (SD) age was 7.3 (4.3) years (range 1.0–17.5 years). Mean duration of burosumab exposure was 29.7 (25.0) months. Overall, 25/67 participants (37.3%) experienced ⩾1 adverse event (AE) during follow-up; 83 AEs were reported. There were no deaths, no AEs leading to treatment withdrawal, nor serious AEs related to treatment. The most frequently reported AEs were classified as ‘musculoskeletal and connective tissue disorders’, with ‘pain in extremity’ most frequently reported, followed by ‘infections and infestations’, with ‘tooth abscess’ the most frequently reported. Conclusion: In this first interim analysis of the PASS, covering the initial 2 years of data collection, the safety profile of burosumab is consistent with previously reported safety data. The PASS will provide long-term safety data over its 10-year duration for healthcare providers and participants with XLH that contribute to improvements in the knowledge of burosumab safety. Trial registration: European Union electronic Register of Post-Authorisation Studies: EUPAS32190.
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- 2024
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24. Triggering Failures: Out-Of-Distribution detection by learning from local adversarial attacks in Semantic Segmentation
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Besnier, Victor, Bursuc, Andrei, Picard, David, and Briot, Alexandre
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In this paper, we tackle the detection of out-of-distribution (OOD) objects in semantic segmentation. By analyzing the literature, we found that current methods are either accurate or fast but not both which limits their usability in real world applications. To get the best of both aspects, we propose to mitigate the common shortcomings by following four design principles: decoupling the OOD detection from the segmentation task, observing the entire segmentation network instead of just its output, generating training data for the OOD detector by leveraging blind spots in the segmentation network and focusing the generated data on localized regions in the image to simulate OOD objects. Our main contribution is a new OOD detection architecture called ObsNet associated with a dedicated training scheme based on Local Adversarial Attacks (LAA). We validate the soundness of our approach across numerous ablation studies. We also show it obtains top performances both in speed and accuracy when compared to ten recent methods of the literature on three different datasets.
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- 2021
25. Music Tempo Estimation via Neural Networks -- A Comparative Analysis
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de Souza, Mila Soares de Oliveira, Moura, Pedro Nuno de Souza, and Briot, Jean-Pierre
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Computer Science - Sound ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Audio and Speech Processing ,I.2 ,I.5.4 ,J.5 - Abstract
This paper presents a comparative analysis on two artificial neural networks (with different architectures) for the task of tempo estimation. For this purpose, it also proposes the modeling, training and evaluation of a B-RNN (Bidirectional Recurrent Neural Network) model capable of estimating tempo in bpm (beats per minutes) of musical pieces, without using external auxiliary modules. An extensive database (12,550 pieces in total) was curated to conduct a quantitative and qualitative analysis over the experiment. Percussion-only tracks were also included in the dataset. The performance of the B-RNN is compared to that of state-of-the-art models. For further comparison, a state-of-the-art CNN was also retrained with the same datasets used for the B-RNN training. Evaluation results for each model and datasets are presented and discussed, as well as observations and ideas for future research. Tempo estimation was more accurate for the percussion only dataset, suggesting that the estimation can be more accurate for percussion-only tracks, although further experiments (with more of such datasets) should be made to gather stronger evidence.
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- 2021
26. Collective management of environmental commons with multiple usages: a guaranteed viability approach
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Alvarez, Isabelle, Zaleski, Laetitia, Briot, Jean-Pierre, and Irving, Marta de Azevedo
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Mathematics - Optimization and Control ,34H05, 93C10, 93C73, 91B76, 90B50 - Abstract
In this paper we address the collective management of environmental commons with multiple usages in the framework of the mathematical viability theory. We consider that the stakeholders can derive from the study of their own socioeconomic problem the variables describing their different usages of the commons and its evolution, and a representation of the desirable states for the commons. We then consider the guaranteed viability kernel, subset of the set of desirable states where it is possible to maintain the state of the commons even when its evolution is represented by several conflicting models. This approach is illustrated on a problem of lake eutrophication., Comment: 25 pages, 5 figures Viability theory reminder in appendix, a diagram and references added
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- 2021
27. Energy Consumption of Deep Generative Audio Models
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Douwes, Constance, Esling, Philippe, and Briot, Jean-Pierre
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Computer Science - Machine Learning ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
In most scientific domains, the deep learning community has largely focused on the quality of deep generative models, resulting in highly accurate and successful solutions. However, this race for quality comes at a tremendous computational cost, which incurs vast energy consumption and greenhouse gas emissions. At the heart of this problem are the measures that we use as a scientific community to evaluate our work. In this paper, we suggest relying on a multi-objective measure based on Pareto optimality, which takes into account both the quality of the model and its energy consumption. By applying our measure on the current state-of-the-art in generative audio models, we show that it can drastically change the significance of the results. We believe that this type of metric can be widely used by the community to evaluate their work, while putting computational cost -- and in fine energy consumption -- in the spotlight of deep learning research., Comment: 5 pages, 2 figures, ICASSP 2022
- Published
- 2021
28. The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data
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Gema Ariceta, Signe Sparre Beck-Nielsen, Annemieke M. Boot, Maria Luisa Brandi, Karine Briot, Carmen de Lucas Collantes, Francesco Emma, Sandro Giannini, Dieter Haffner, Richard Keen, Elena Levtchenko, Outi Mӓkitie, M. Zulf Mughal, Ola Nilsson, Dirk Schnabel, Liana Tripto-Shkolnik, Jonathan Liu, Angela Williams, Sue Wood, and M. Carola Zillikens
- Subjects
X-linked hypophosphatemia (XLH) ,Hypophosphatemic rickets ,Rare disease ,International ,Natural history ,Osteomalacia ,Medicine - Abstract
Abstract Background X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive, renal phosphate-wasting disorder characterized by a pathological increase in FGF23 concentration and activity. Due to its rarity, diagnosis may be delayed, which can adversely affect outcomes. As a chronic disease resulting in progressive accumulation of musculoskeletal manifestations, it is important to understand the natural history of XLH over the patient’s lifetime and the impact of drug treatments and other interventions. This multicentre, international patient registry (International XLH Registry) was established to address the paucity of these data. Here we present the findings of the first interim analysis of the registry. Results The International XLH Registry was initiated in August 2017 and includes participants of all ages diagnosed with XLH, regardless of their treatment and management. At the database lock for this first interim analysis (29 March 2021), 579 participants had entered the registry before 30 November 2020 and are included in the analysis (360 children [62.2%], 217 adults [37.5%] and 2 whose ages were not recorded [0.3%]; 64.2% were female). Family history data were available for 319/345 (92.5%) children and 145/187 (77.5%) adults; 62.1% had biological parents affected by XLH. Genetic testing data were available for 341 (94.7%) children and 203 (93.5%) adults; 370/546 (67.8%) had genetic test results; 331/370 (89.5%) had a confirmed PHEX mutation. A notably longer time to diagnosis was observed in adults ≥ 50 years of age (mean [median] duration 9.4 [2.0] years) versus all adults (3.7 [0.1] years) and children (1.0 [0.2] years). Participants presented with normal weight, shorter length or height and elevated body mass index (approximately − 2 and + 2 Z-scores, respectively) versus the general population. Clinical histories were collected for 349 participants (239 children and 110 adults). General data trends for prevalence of bone, dental, renal and joint conditions in all participants were aligned with expectations for a typical population of people with XLH. Conclusion The data collected within the International XLH Registry, the largest XLH registry to date, provide substantial information to address the paucity of natural history data, starting with demographic, family history, genetic testing, diagnosis, auxology and baseline data on clinical presentation.
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- 2023
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29. Learning Uncertainty For Safety-Oriented Semantic Segmentation In Autonomous Driving
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Besnier, Victor, Picard, David, and Briot, Alexandre
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In this paper, we show how uncertainty estimation can be leveraged to enable safety critical image segmentation in autonomous driving, by triggering a fallback behavior if a target accuracy cannot be guaranteed. We introduce a new uncertainty measure based on disagreeing predictions as measured by a dissimilarity function. We propose to estimate this dissimilarity by training a deep neural architecture in parallel to the task-specific network. It allows this observer to be dedicated to the uncertainty estimation, and let the task-specific network make predictions. We propose to use self-supervision to train the observer, which implies that our method does not require additional training data. We show experimentally that our proposed approach is much less computationally intensive at inference time than competing methods (e.g. MCDropout), while delivering better results on safety-oriented evaluation metrics on the CamVid dataset, especially in the case of glare artifacts.
- Published
- 2021
30. Correction: Creating a health informatics data resource for hearing health research
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Nishchay Mehta, Baptiste Briot Ribeyre, Lilia Dimitrov, Louise J. English, Colleen Ewart, Antje Heinrich, Nikhil Joshi, Kevin J. Munro, Gail Roadknight, Luis Romao, Anne Gm Schilder, Ruth V. Spriggs, Ruth Norris, Talisa Ross, and George Tilston
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Computer applications to medicine. Medical informatics ,R858-859.7 - Published
- 2024
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31. Phage Therapy in a Burn Patient Colonized with Extensively Drug-Resistant Pseudomonas aeruginosa Responsible for Relapsing Ventilator-Associated Pneumonia and Bacteriemia
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Cécile Teney, Jean-Charles Poupelin, Thomas Briot, Myrtille Le Bouar, Cindy Fevre, Sophie Brosset, Olivier Martin, Florent Valour, Tiphaine Roussel-Gaillard, Gilles Leboucher, Florence Ader, Anne-Claire Lukaszewicz, and Tristan Ferry
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Pseudomonas aeruginosa ,antimicrobial resistance ,phage therapy ,burns ,ICU ,ventilator-associated pneumonia ,Microbiology ,QR1-502 - Abstract
Pseudomonas aeruginosa is one of the main causes of healthcare-associated infection in Europe that increases patient morbidity and mortality. Multi-resistant pathogens are a major public health issue in burn centers. Mortality increases when the initial antibiotic treatment is inappropriate, especially if the patient is infected with P. aeruginosa strains that are resistant to many antibiotics. Phage therapy is an emerging option to treat severe P. aeruginosa infections. It involves using natural viruses called bacteriophages, which have the ability to infect, replicate, and, theoretically, destroy the P. aeruginosa population in an infected patient. We report here the case of a severely burned patient who experienced relapsing ventilator-associated pneumonia associated with skin graft infection and bacteremia due to extensively drug-resistant P. aeruginosa. The patient was successfully treated with personalized nebulized and intravenous phage therapy in combination with immunostimulation (interferon-γ) and last-resort antimicrobial therapy (imipenem-relebactam).
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- 2024
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32. Bilayer Stiffness Identification of Soft Tissues by Suction
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Connesson, N., Briot, N., Rohan, P. Y., Barraud, P. A., Elahi, S. A., and Payan, Y.
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- 2023
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33. Steroid hormone pathways, vitamin D and autism: a systematic review
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Amestoy, Anouck, Baudrillard, Claire, Briot, Kellen, Pizano, Adrien, Bouvard, Manuel, and Lai, Meng-Chuan
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- 2023
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34. Down-regulation of peptidylarginine deiminase type 1 in reconstructed human epidermis disturbs nucleophagy in the granular layer and affects barrier function
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Adebayo Candide Alioli, Julie Briot, Carole Pons, Hang Yang, Marie Gairin, Dominique Goudounèche, Laura Cau, Michel Simon, and Marie-Claire Méchin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Deimination is a post-translational modification catalyzed by a family of enzymes named peptidylarginine deiminases (PADs). PADs transform arginine residues of protein substrates into citrulline. Deimination has been associated with numerous physiological and pathological processes. In human skin, three PADs are expressed (PAD1-3). While PAD3 is important for hair shape formation, the role of PAD1 is less clear. To decipher the main role(s) of PAD1 in epidermal differentiation, its expression was down-regulated using lentivirus-mediated shRNA interference in primary keratinocytes and in three-dimensional reconstructed human epidermis (RHE). Compared to normal RHEs, down-regulation of PAD1 caused a drastic reduction in deiminated proteins. Whereas proliferation of keratinocytes was not affected, their differentiation was disturbed at molecular, cellular and functional levels. The number of corneocyte layers was significantly reduced, expression of filaggrin and cornified cell envelope components, such as loricrin and transglutaminases, was down-regulated, epidermal permeability increased and trans-epidermal-electric resistance diminished drastically. Keratohyalin granule density decreased and nucleophagy in the granular layer was disturbed. These results demonstrate that PAD1 is the main regulator of protein deimination in RHE. Its deficiency alters epidermal homeostasis, affecting the differentiation of keratinocytes, especially the cornification process, a special kind of programmed cell death.
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- 2023
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35. Pathologic and immunohistochemical prognostic markers in residual triple-negative breast cancer after neoadjuvant chemotherapy
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Silvia Mihaela Ilie, Nathalie Briot, Guillaume Constatin, Alis Ilie, Francoise Beltjens, Sylvain Ladoire, Isabelle Desmoulins, Audrey Hennequin, Aurelie Bertaut, Charles Coutant, Sylvain Causeret, Niama Ghozali, Bruno Coudert, and Laurent Arnould
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neoadjuvant chemotherapy ,residual disease ,triple-negative breast cancer ,prognostic biomarkers ,immunohistochemical marker ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundThe persistence of residual tumour after neoadjuvant chemotherapy (NAC) in localised triple-negative breast cancer (TNBC) is known to have a negative prognostic value. However, different degrees of expression of some immunohistochemical markers may correlate with different prognoses.MethodsThe expression of biomarkers with a known prognostic value, i.e., cytokeratin 5/6 (CK5/6), androgen receptor (AR), epidermal growth factor receptor (EGFR) proliferation-related nuclear antigen Ki-67, human epidermal growth factor receptor 2 (HER2), protein 53 (p53), forkhead box protein 3 (FOXP3), and cluster differentiation 8 (CD8), was analysed by immunohistochemistry in 111 samples after NAC in non-metastatic TNBC patients addressed to Georges-François Leclerc Cancer Centre Dijon, France. Clinical and pathological variables were retrospectively collected. Cox regression was used to identify immunohistochemical (IHC) and clinicopathological predictors of event-free survival (EFS) (relapse or death).ResultsMedian age was 50.4 years (range 25.6–88.3), 55.9% (n = 62) were non-menopausal, 70 (63.1%) had stage IIA–IIB disease. NAC was mostly sequential anthracycline-taxanes (72.1%), and surgical intervention was principally conservative (51.3%). We found 65.7% ypT1, 47.2% lymph node involvement (ypN+), and 29.4% lymphovascular invasion (LVI). Most residual tumours were EGFR >110 (H-score) (60.5%, n = 66), AR ≥4% (53.2%, n = 58), p53-positive mutated (52.7%, n = 58), CD8 ≥26 (58.1%, n = 61), FOXP3 ≥7 (51.4%, n = 54), more than half in the stroma, and 52.3% (n = 58) HER2 score 0. After a median follow-up of 80.8 months, 48.6% had relapsed. Median EFS was 62.3 months (95% CI, 37.2–not reached (NR)). Factors independently associated with poor EFS were AR-low (p = 0.002), ypN+ (p < 0.001), and LVI (p = 0.001). Factors associated with lower overall survival (OS) were EGFR-low (p = 0.041), Ki-67 high (p = 0.024), and ypN+ (p < 0.001).ConclusionPost-NAC residual disease in TNBC showed biomarkers specific to a basal-like subtype and markers of lymphocyte infiltration mostly present in the stroma. Prognostic markers for EFS were AR, LVI, and ypN and warrant further validation in a prognostic model.
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- 2024
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36. From Artificial Neural Networks to Deep Learning for Music Generation -- History, Concepts and Trends
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Briot, Jean-Pierre
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Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Machine Learning ,Computer Science - Multimedia ,Computer Science - Sound ,Statistics - Machine Learning - Abstract
The current wave of deep learning (the hyper-vitamined return of artificial neural networks) applies not only to traditional statistical machine learning tasks: prediction and classification (e.g., for weather prediction and pattern recognition), but has already conquered other areas, such as translation. A growing area of application is the generation of creative content, notably the case of music, the topic of this paper. The motivation is in using the capacity of modern deep learning techniques to automatically learn musical styles from arbitrary musical corpora and then to generate musical samples from the estimated distribution, with some degree of control over the generation. This paper provides a tutorial on music generation based on deep learning techniques. After a short introduction to the topic illustrated by a recent exemple, the paper analyzes some early works from the late 1980s using artificial neural networks for music generation and how their pioneering contributions have prefigured current techniques. Then, we introduce some conceptual framework to analyze the various concepts and dimensions involved. Various examples of recent systems are introduced and analyzed to illustrate the variety of concerns and of techniques., Comment: To appear in the Special Issue on Art, Sound and Design in the Neural Computing and Applications Journal
- Published
- 2020
37. Real‐World Effectiveness of Osteoporosis Medications in France: A Nationwide Cohort Study
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Pauline Bosco‐Lévy, Karine Briot, Nadia Mehsen‐Cetre, James O'Kelly, Gaëlle Désaméricq, Abdelilah Abouelfath, Régis Lassalle, Angela Grelaud, Adeline Grolleau, Patrick Blin, and Cécile Droz‐Perroteau
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ANTIRESORPTIVE MEDICATIONS ,FRACTURE INCIDENCE ,HEALTHCARE DATABASE ,OSTEOPOROSIS ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
ABSTRACT Although drugs for osteoporosis have been demonstrated to be effective in reducing fracture risk in placebo‐controlled clinical trials, data on effectiveness in real‐world practice is limited. Data from the French national health insurance claims database (SNDS) were used to follow five cohorts of women aged ≥55 years after initiating treatment for ≥6 months with either denosumab, zoledronic acid, oral bisphosphonates, raloxifene, or teriparatide in 2014–2016. Fracture incidence was compared within each cohort between the 3 months following initiation (baseline fracture risk) and the 12month, 18month, and 24 month postinitiation periods. Data are presented as incidence rate ratios (IRRs) with their 95% confidence intervals (CIs)s. Overall, 67,046 women were included in the denosumab cohort, 52,914 in the oral bisphosphonate cohort, 41,700 in the zoledronic acid cohort, 11,600 in the raloxifene cohort, and 7510 in the teriparatide cohort. The baseline vertebral fracture rate ranged from 1.74 per 1000 person years (‰PY) in the raloxifene cohort to 34.75‰PY in the teriparatide cohort, and the baseline hip fracture rate from 0.70‰PY in the raloxifene cohort to 10.52‰PY in the zoledronic acid cohort. Compared with the baseline fracture rate, vertebral fractures involving hospitalization were significantly reduced in the 3–24–month postinitiation period with denosumab (IRR 0.6; 95% CI, 0.5–0.7), zoledronic acid (IRR 0.4; 95% CI, 0.3–0.4), teriparatide (IRR 0.3; 95% CI, 0.2–0.5), and oral bisphosphonates (IRR 0.6; 95% CI, 0.4–0.8). Hip fracture incidence was reduced with denosumab (IRR 0.8; 95% CI, 0.6–0.9), but higher for oral bisphosphonates (IRR 1.7; 95% CI, 1.2–2.3); no significant change in hip fracture rate was observed for zoledronic acid, teriparatide, or raloxifene. A reduction in nonvertebral, non‐hip fracture incidence was observed only in the denosumab cohort (IRR 0.8; 95% CI, 0.7–0.9). These findings indicate that treatment with osteoporosis drugs is effective in the real‐world setting. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
- Published
- 2023
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38. Editorial: New frontiers in parallel robotics
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Sébastien Briot and Jessica Burgner-Kahrs
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parallel robot ,continuum robot ,cable-driven manipulator ,underactuated robot hand ,parallel manipulator ,Mechanical engineering and machinery ,TJ1-1570 ,Electronic computers. Computer science ,QA75.5-76.95 - Published
- 2023
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39. Leveraging Model Interpretability and Stability to increase Model Robustness
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Wu, Fei, Michel, Thomas, and Briot, Alexandre
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Computer Science - Machine Learning ,Computer Science - Computer Vision and Pattern Recognition ,Statistics - Machine Learning - Abstract
State of the art Deep Neural Networks (DNN) can now achieve above human level accuracy on image classification tasks. However their outstanding performances come along with a complex inference mechanism making them arduously interpretable models. In order to understand the underlying prediction rules of DNNs, Dhamdhere et al. propose an interpretability method to break down a DNN prediction score as sum of its hidden unit contributions, in the form of a metric called conductance. Analyzing conductances of DNN hidden units, we find out there is a difference in how wrong and correct predictions are inferred. We identify distinguishable patterns of hidden unit activations for wrong and correct predictions. We then use an error detector in the form of a binary classifier on top of the DNN to automatically discriminate wrong and correct predictions of the DNN based on their hidden unit activations. Detected wrong predictions are discarded, increasing the model robustness. A different approach to distinguish wrong and correct predictions of DNNs is proposed by Wang et al. whose method is based on the premise that input samples leading a DNN into making wrong predictions are less stable to the DNN weight changes than correctly classified input samples. In our study, we compare both methods and find out by combining them that better detection of wrong predictions can be achieved., Comment: 2019 ICCV workshop on Interpreting and Explaining Visual AI models; 8 pages
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- 2019
40. InSe as a case between 3D and 2D layered crystals for excitons
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Desrat, W., Shubina, T. V., Moret, M., Tiberj, A., Briot, O., and Gil, B.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We demonstrate the successive appearance of the exciton, biexciton, and P band of the exciton-exciton scattering with increasing excitation power in the photoluminescence of indium selenide layered crystals. The strict energy and momentum conservation rules of the P band are used to reexamine the exciton binding energy. The new value $\geq 20$ meV is markedly higher than the currently accepted 14 meV, being however well consistent with the robustness of excitons up to room temperature. A peak controlled by the Sommerfeld factor is found near the bandgap ($\sim 1.36$ eV), which puts the question on the pure three-dimensional character of the exciton in InSe, which has been assumed up to now. Our findings are of paramount importance for the successful application of InSe in nanophotonics., Comment: 6 pages, 4 figures
- Published
- 2019
41. Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study
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Brandi, Maria Luisa, Jan de Beur, Suzanne, Briot, Karine, Carpenter, Thomas, Cheong, Hae Il, Cohen-Solal, Martine, Crowley, Rachel K., Eastell, Richard, Imanishi, Yasuo, Imel, Erik A., Ing, Steven W., Insogna, Karl, Ito, Nobuaki, Javaid, Kassim, Kamenicky, Peter, Keen, Richard, Kubota, Takuo, Lachmann, Robin H., Perwad, Farzana, Pitukcheewanont, Pisit, Portale, Anthony, Ralston, Stuart H., Tanaka, Hiroyuki, Weber, Thomas J., Yoo, Han-Wook, Sun, Wei, Williams, Angela, Nixon, Annabel, and Takeuchi, Yasuhiro
- Published
- 2022
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42. Une géographie de la solidarité des villes françaises
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Ninon Briot
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International solidarity ,Cities ,Cooperation ,City diplomacy ,Geography (General) ,G1-922 - Abstract
This article aims to analyse the international solidarity relations undertaken by French cities. These international cooperations are multiple, and the actions of solidarity, called decentralized cooperation, are characterized by their spatial scope and their practices. The aim is to examine the concept of solidarity and in particular the evolution of its conception within these relations. The purpose of this paper is to study the geography of solidarity in French cities by means of a census of the cooperative projects carried out by the 80 largest French cities, followed by a semi-directive interview survey. Three results have emerged. First, the solidarity relations conducted by French cities are similar to development assistance in very specific areas related to the French legal corpus and lead to a strong asymmetry in the relationship. Secondly, the geographical distribution of these relations is based on the influence areas of French diplomacy, as a result of numerous incentives from the Ministry of Foreign Affairs. Finally, the study of these cooperations shows how the notion of solidarity evolves through the growing imperative of reciprocity in the exchange.
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- 2022
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43. Anticipated effects of burosumab treatment on long-term clinical sequelae in XLH: expert perspectives
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Lothar Seefried, Martin Biosse Duplan, Karine Briot, Michael T. Collins, Rachel Evans, Pablo Florenzano, Neil Hawkins, Muhammad Kassim Javaid, Robin Lachmann, and Leanne M. Ward
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burosumab ,X-linked hypophosphatemia ,fibroblast growth factor 23 ,phosphate metabolism ,hypophosphatemia ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
X-linked hypophosphatemia (XLH) is a rare, progressive, genetic disease with multisystem impact that typically begins to manifest in early childhood. Two treatment options exist: oral phosphate in combination with active vitamin D (“conventional therapy”) and a fully human monoclonal anti-FGF23 antibody, burosumab. The clinical benefit of conventional therapy in adults is limited, and poor tolerance and complications are common. Burosumab was first approved as a treatment for XLH in 2018 and its disease-modifying benefits in clinical trials in children suggest burosumab treatment could also alter the disease course in adults. Without long-term clinical data on multiple XLH-related sequelae available, the results of an elicitation exercise are reported, in which eight global experts in XLH posited how long-term treatment with burosumab is anticipated to impact the life course of clinical sequelae in adults with XLH. Based on their clinical experiences, the available evidence and their disease understanding, the experts agreed that some long-term benefits of using burosumab are likely in adults with XLH even if they have a misaligned skeleton from childhood. Burosumab treatment is anticipated to reduce the incidence of fractures and halt the progression of clinical sequelae associated with conventional therapy. While the trajectories for established dental abscesses are not expected to improve with burosumab treatment, dental abscess development may be prevented. Starting treatment with burosumab in childhood to increase the likelihood of an aligned skeleton and continuation into and throughout adulthood to maintain euphosphatemia may optimize patient outcomes, although future real-world investigation is required to support this hypothesis.
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- 2023
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44. Experimental characterisation and modelling of breast Cooper’s ligaments
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Briot, N., Chagnon, G., Burlet, L., Gil, H., Girard, E., and Payan, Y.
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- 2022
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45. Prehistory of Transit Searches
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Briot, Danielle and Schneider, Jean
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Nowadays the more powerful method to detect extrasolar planets is the transit method. We review the planet transits which were anticipated, searched, and the first ones which were observed all through history. Indeed transits of planets in front of their star were first investigated and studied in the solar system. The first observations of sunspots were sometimes mistaken for transits of unknown planets. The first scientific observation and study of a transit in the solar system was the observation of Mercury transit by Pierre Gassendi in 1631. Because observations of Venus transits could give a way to determine the distance Sun-Earth, transits of Venus were overwhelmingly observed. Some objects which actually do not exist were searched by their hypothetical transits on the Sun, as some examples a Venus satellite and an infra-mercurial planet. We evoke the possibly first use of the hypothesis of an exoplanet transit to explain some periodic variations of the luminosity of a star, namely the star Algol, during the eighteen century. Then we review the predictions of detection of exoplanets by their transits, those predictions being sometimes ancient, and made by astronomers as well as popular science writers. However, these very interesting predictions were never published in peer-reviewed journals specialized in astronomical discoveries and results. A possible transit of the planet beta Pic b was observed in 1981. Shall we see another transit expected for the same planet during 2018? Today, some studies of transits which are connected to hypothetical extraterrestrial civilisations are published in astronomical refereed journals. Some studies which would be classified not long ago as science fiction are now considered as scientific ones., Comment: Submiited to Handbook of Exoplanets (Springer)
- Published
- 2018
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46. Music Generation by Deep Learning - Challenges and Directions
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Briot, Jean-Pierre and Pachet, François
- Subjects
Computer Science - Sound ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
In addition to traditional tasks such as prediction, classification and translation, deep learning is receiving growing attention as an approach for music generation, as witnessed by recent research groups such as Magenta at Google and CTRL (Creator Technology Research Lab) at Spotify. The motivation is in using the capacity of deep learning architectures and training techniques to automatically learn musical styles from arbitrary musical corpora and then to generate samples from the estimated distribution. However, a direct application of deep learning to generate content rapidly reaches limits as the generated content tends to mimic the training set without exhibiting true creativity. Moreover, deep learning architectures do not offer direct ways for controlling generation (e.g., imposing some tonality or other arbitrary constraints). Furthermore, deep learning architectures alone are autistic automata which generate music autonomously without human user interaction, far from the objective of interactively assisting musicians to compose and refine music. Issues such as: control, structure, creativity and interactivity are the focus of our analysis. In this paper, we select some limitations of a direct application of deep learning to music generation, analyze why the issues are not fulfilled and how to address them by possible approaches. Various examples of recent systems are cited as examples of promising directions., Comment: 17 pages. arXiv admin note: substantial text overlap with arXiv:1709.01620. Accepted for publication in Special Issue on Deep learning for music and audio, Neural Computing & Applications, Springer Nature, 2018
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- 2017
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47. High doses of tyramine stimulate glucose transport in human fat cells
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Carpéné, Christian, Les, Francisco, Mercader-Barceló, Josep, Boulet, Nathalie, Briot, Anaïs, and Grolleau, Jean-Louis
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- 2022
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48. Singularity Analysis for the Perspective-Four and Five-Line Problems
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García Fontán, Jorge, Nayak, Abhilash, Briot, Sébastien, and Safey El Din, Mohab
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- 2022
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49. Osteogenesis Imperfecta: characterization of fractures during pregnancy and post-partum
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Koumakis, Eugénie, Cormier-Daire, Valérie, Dellal, Azeddine, Debernardi, Marc, Cortet, Bernard, Debiais, Françoise, Javier, Rose-Marie, Thomas, Thierry, Mehsen-Cetre, Nadia, Cohen-Solal, Martine, Fontanges, Elisabeth, Laroche, Michel, Porquet-Bordes, Valérie, Marcelli, Christian, Benachi, Alexandra, Briot, Karine, Roux, Christian, and Cormier, Catherine
- Published
- 2022
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50. Deep Learning Techniques for Music Generation -- A Survey
- Author
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Briot, Jean-Pierre, Hadjeres, Gaëtan, and Pachet, François-David
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Computer Science - Sound ,Computer Science - Machine Learning - Abstract
This paper is a survey and an analysis of different ways of using deep learning (deep artificial neural networks) to generate musical content. We propose a methodology based on five dimensions for our analysis: Objective - What musical content is to be generated? Examples are: melody, polyphony, accompaniment or counterpoint. - For what destination and for what use? To be performed by a human(s) (in the case of a musical score), or by a machine (in the case of an audio file). Representation - What are the concepts to be manipulated? Examples are: waveform, spectrogram, note, chord, meter and beat. - What format is to be used? Examples are: MIDI, piano roll or text. - How will the representation be encoded? Examples are: scalar, one-hot or many-hot. Architecture - What type(s) of deep neural network is (are) to be used? Examples are: feedforward network, recurrent network, autoencoder or generative adversarial networks. Challenge - What are the limitations and open challenges? Examples are: variability, interactivity and creativity. Strategy - How do we model and control the process of generation? Examples are: single-step feedforward, iterative feedforward, sampling or input manipulation. For each dimension, we conduct a comparative analysis of various models and techniques and we propose some tentative multidimensional typology. This typology is bottom-up, based on the analysis of many existing deep-learning based systems for music generation selected from the relevant literature. These systems are described and are used to exemplify the various choices of objective, representation, architecture, challenge and strategy. The last section includes some discussion and some prospects., Comment: 209 pages. This paper is a simplified version of the book: J.-P. Briot, G. Hadjeres and F.-D. Pachet, Deep Learning Techniques for Music Generation, Computational Synthesis and Creative Systems, Springer, 2019
- Published
- 2017
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