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1. Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Author

Nolte, Ilja M, Munoz, M Loretto, Tragante, Vinicius, Amare, Azmeraw T, Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L, Bis, Joshua C, Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M, Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F, Kluttig, Alexander, Krijthe, Bouwe P, Kumar, Jitender, van der Laan, Sander W, Lyytikäinen, Leo-Pekka, Maihofer, Adam X, Minassian, Arpi, van der Most, Peter J, Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D, Thayer, Julian F, Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G, de Bakker, Paul IW, Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J, Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R, Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B, Ellinor, Patrick T, Eskola, Markku, Felix, Janine F, Floras, John S, Franco, Oscar H, Friberg, Peter, Gademan, Maaike GJ, Geyer, Mark A, Giedraitis, Vilmantas, Hartman, Catharina A, Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M, Kors, Jan A, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C, Lefrandt, Joop D, Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C, Lin, Henry J, Lindgren, Cecilia M, Lubitz, Steven A, Mahajan, Anubha, McKnight, Barbara, Zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P, Nalls, Mike A, Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E, O'Connor, Daniel T, Ormel, Johan, Perz, Siegfried, Peters, Annette, and Psaty, Bruce M

Subjects
Humans, Heart Diseases, Genetic Predisposition to Disease, RGS Proteins, Potassium Channels, Muscle Proteins, Risk Factors, Cohort Studies, Blood Pressure, Heart Rate, Polymorphism, Single Nucleotide, Quantitative Trait Loci, European Continental Ancestry Group, Genome-Wide Association Study, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Cardiovascular, Genetics, Heart Disease
Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74g

Published
2017

2. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B, Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriëtte, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J.M, Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.

Published
2017
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4. Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction: A Meta-analysis

Author

Den Ruijter, Hester M., Peters, Sanne A., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline M., Eijkemans, Marinus J., Engström, Gunnar, Evans, Gregory W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Hofman, Albert, Holewijn, Suzanne, Ikeda, Ai, Kavousi, Maryam, Kitagawa, Kazuo, Kitamura, Akihiko, Koffijberg, Hendrik, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, O’Leary, Daniel H., Polak, Joseph F., Price, Jackie F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D., Witteman, Jacqueline C., Moons, Karel G., and Bots, Michiel L.

Published
2012
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10. Alcohol consumption and common carotid intima-media thickness : The USE-IMT study

Author

Britton, Annie R., Grobbee, Diederick E., den Ruijter, Hester M., Anderson, Todd J., Desvarieux, Moise, Engström, Gunnar, Evans, Greg W., Hedblad, Bo, Kauhanen, Jussi, Kurl, Sudhir, Lonn, Eva M., Mathiesen, Ellisiv B., Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Stehouwer, Coen D. A., Tuomainen, Tomi-Pekka, Bots, Michiel L., MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, and Interne Geneeskunde

Subjects
Male, carotid intima-media thickness, Medicine (miscellaneous), Original Manuscript, heavy drinking, Toxicology, BENEFITS, Humans, cardiovascular diseases, METAANALYSIS, RISK, OLDER, Sweden, Medicine(all), ADULTS, ASSOCIATION, Middle Aged, Protective Factors, moderate drinking, alcohol drinking, ARTERY STRUCTURE, Psychiatry and Mental health, Case-Control Studies, cardiovascular system, linear regression, MODERATE, HEALTH, ethanol, atherosclerosis
Abstract

Aims Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption. Results The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (10 g per day, after adjusting for a range of confounding factors. Conclusion In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.

Published
2017
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11. Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study

Author

Britton Annie R, Grobbee Diederick E, den Ruijter Hester M, Anderson Todd J, Desvarieux Moise, Engström Gunnar, Evans Greg W, Hedblad Bo, Kauhanen Jussi, Kurl Sudhir, Lonn Eva M, Mathiesen Ellisiv B, Polak Joseph F, Price Jacqueline F, Rembold Christopher M, Rosvall Maria, Rundek Tatjana, Salonen Jukka T, Stehouwer Coen, Tuomainen Tomi-Pekka et al., and School of Medicine / Public Health

Subjects
carotid intima-media thickness, cardiovascular system, linear regression, heavy drinking, cardiovascular diseases, ethanol, atherosclerosis, moderate drinking, alcohol drinking
Abstract

Aims Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption. Results The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (10 g per day, after adjusting for a range of confounding factors. Conclusion In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT., published version, peerReviewed

Published
2017

12. Genetic loci associated with heart rate variability and their effects on cardiac disease risk (vol 8, pg 15805, 2017)

Author

Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikainen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Mueller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kahonen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundstrom, Johan, Swenne, Cees A., Syvanen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, Andre G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Jarvelin, Marjo-Riitta, Kaab, Stefan, Kahonen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimaki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriette, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J. M., Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, de Geus, Eco J. C., Biological Psychology, APH - Mental Health, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Methodology, APH - Health Behaviors & Chronic Diseases, Faculty of Religion and Theology, and Environmental Geography (former)

Subjects
Netherlands Twin Register (NTR), Cardiovascular genetics Genome-wide association studies Risk factors
Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74

Published
2017
Full Text
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13. Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikainen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Mueller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid E., Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kahonen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundstrom, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, Andre G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Jarvelin, Marjo-Riitta, Kaab, Stefan, Kahonen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimaki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriette, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J. M., Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, de Geus, Eco J. C., Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikainen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Mueller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid E., Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kahonen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundstrom, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, Andre G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Jarvelin, Marjo-Riitta, Kaab, Stefan, Kahonen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimaki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriette, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J. M., Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74 < r(g) < -0.55) and blood pressure (-0.35 < r(g) < -0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.

Published
2017
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14. Clustering of cardiovascular risk factors and carotid intima-media thickness : The USE-IMT study

Author

Wang, Xin, Dalmeijer, Gerdien, Den Ruijter, Hester M., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline, Engström, Gunnar, Evans, Greg W., De Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kauhanen, Jussi, Kitagawa, Kazuo, Kitamura, Akihiko, Kurl, Sudhir, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D A, Tuomainen, Tomi Pekka, Peters, Sanne A E, Bots, Michiel L., Wang, Xin, Dalmeijer, Gerdien, Den Ruijter, Hester M., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline, Engström, Gunnar, Evans, Greg W., De Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kauhanen, Jussi, Kitagawa, Kazuo, Kitamura, Akihiko, Kurl, Sudhir, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D A, Tuomainen, Tomi Pekka, Peters, Sanne A E, and Bots, Michiel L.

Published
2017

15. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Circulatory Health, Onderzoek Precision medicine, Experimentele Afd. Cardiologie 1, CMM Groep Kaaij, Infection & Immunity, Aios en Stafsecr. Cardiologie, Team Medisch, Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, Von Der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F, Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W, Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel G, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad Hadi, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram N, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I W, Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret I., Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid E., Dietrich, Andrea, Ehret, George B, Ellinor, Patrick T, Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G.J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki V., Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun R., Liao, Duanping, Limacher, Marian C., Lin, Henry J, Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, Zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan J., Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F, Siscovick, David S., Smit, Johannes H, Smith, Nicholas L., Soliman, Elsayed Z, Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K, Greiser, Karin Halina, van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J, Oldehinkel, Albertine J., Penninx, Brenda Wjh, Reiner, Alexander P, Riese, Harriëtte, Van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G M, Asselbergs, Folkert W, Brundel, Bianca J.J.M., Heckbert, Susan R, Whitsel, Eric A, den Hoed, Marcel, Snieder, Harold, de Geus, Eco J. C., Circulatory Health, Onderzoek Precision medicine, Experimentele Afd. Cardiologie 1, CMM Groep Kaaij, Infection & Immunity, Aios en Stafsecr. Cardiologie, Team Medisch, Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, Von Der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F, Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W, Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel G, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad Hadi, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram N, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I W, Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret I., Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid E., Dietrich, Andrea, Ehret, George B, Ellinor, Patrick T, Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G.J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki V., Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun R., Liao, Duanping, Limacher, Marian C., Lin, Henry J, Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, Zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan J., Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F, Siscovick, David S., Smit, Johannes H, Smith, Nicholas L., Soliman, Elsayed Z, Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K, Greiser, Karin Halina, van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J, Oldehinkel, Albertine J., Penninx, Brenda Wjh, Reiner, Alexander P, Riese, Harriëtte, Van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G M, Asselbergs, Folkert W, Brundel, Bianca J.J.M., Heckbert, Susan R, Whitsel, Eric A, den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.

Published
2017

16. Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Aios en Stafsecr. Cardiologie, Circulatory Health, Onderzoek Precision medicine, Experimentele Afd. Cardiologie 1, Genetica, Cardiovasculaire Epi Team 7a, CMM Groep Kaaij, Infection & Immunity, Team Medisch, Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, Von Der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F, Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, Van Der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel G, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad Hadi, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram N, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., De Bakker, Paul I.W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret I., Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid E., Dietrich, Andrea, Ehret, George B, Ellinor, Patrick T, Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G.J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki V., Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun R., Liao, Duanping, Limacher, Marian C., Lin, Henry J, Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, Meyer Zu Schwabedissen, Henriette, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan J., Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F, Siscovick, David S., Smit, Johannes H, Smith, Nicholas L., Soliman, Elsayed Z, Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., Van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K, Greiser, Karin Halina, van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J, Oldehinkel, Albertine J., Penninx, Brenda Wjh, Reiner, Alexander P, Riese, Harriëtte, Van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G M, Asselbergs, Folkert W., Brundel, Bianca J.J.M., Heckbert, Susan R, Whitsel, Eric A, den Hoed, Marcel, Snieder, Harold, de Geus, Eco J. C., Aios en Stafsecr. Cardiologie, Circulatory Health, Onderzoek Precision medicine, Experimentele Afd. Cardiologie 1, Genetica, Cardiovasculaire Epi Team 7a, CMM Groep Kaaij, Infection & Immunity, Team Medisch, Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, Von Der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F, Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, Van Der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel G, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad Hadi, Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram N, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., De Bakker, Paul I.W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret I., Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid E., Dietrich, Andrea, Ehret, George B, Ellinor, Patrick T, Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G.J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki V., Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A, Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun R., Liao, Duanping, Limacher, Marian C., Lin, Henry J, Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, Meyer Zu Schwabedissen, Henriette, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan J., Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F, Siscovick, David S., Smit, Johannes H, Smith, Nicholas L., Soliman, Elsayed Z, Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., Van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K, Greiser, Karin Halina, van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J, Oldehinkel, Albertine J., Penninx, Brenda Wjh, Reiner, Alexander P, Riese, Harriëtte, Van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G M, Asselbergs, Folkert W., Brundel, Bianca J.J.M., Heckbert, Susan R, Whitsel, Eric A, den Hoed, Marcel, Snieder, Harold, and de Geus, Eco J. C.

Published
2017

17. Alcohol consumption and common carotid intima-media thickness: The USE-IMT study

Author

Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Experimentele Afd. Cardiologie 1, Cardiovasculaire Epi Team 5, Britton, Annie R., Grobbee, Diederick E., den Ruijter, Hester M., Anderson, Todd J., Desvarieux, Moise, Engström, Gunnar, Evans, Greg W., Hedblad, Bo, Kauhanen, Jussi, Kurl, Sudhir, Lonn, Eva M., Mathiesen, Ellisiv B., Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Stehouwer, Coen D. A., Tuomainen, Tomi-Pekka, Bots, Michiel L., Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Experimentele Afd. Cardiologie 1, Cardiovasculaire Epi Team 5, Britton, Annie R., Grobbee, Diederick E., den Ruijter, Hester M., Anderson, Todd J., Desvarieux, Moise, Engström, Gunnar, Evans, Greg W., Hedblad, Bo, Kauhanen, Jussi, Kurl, Sudhir, Lonn, Eva M., Mathiesen, Ellisiv B., Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Stehouwer, Coen D. A., Tuomainen, Tomi-Pekka, and Bots, Michiel L.

Published
2017

18. Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study

Author

Public Health Practice, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Onderzoek Vrouw Hart & Vaatziekten, Cardiovasculaire Epi Team 9, Cardiovasculaire Epi Team 5, Wang, Xin, Dalmeijer, Gerdien, Den Ruijter, Hester M., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline, Engström, Gunnar, Evans, Greg W., De Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kauhanen, Jussi, Kitagawa, Kazuo, Kitamura, Akihiko, Kurl, Sudhir, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D A, Tuomainen, Tomi Pekka, Peters, Sanne A E, Bots, Michiel L., Public Health Practice, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Onderzoek Vrouw Hart & Vaatziekten, Cardiovasculaire Epi Team 9, Cardiovasculaire Epi Team 5, Wang, Xin, Dalmeijer, Gerdien, Den Ruijter, Hester M., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline, Engström, Gunnar, Evans, Greg W., De Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kauhanen, Jussi, Kitagawa, Kazuo, Kitamura, Akihiko, Kurl, Sudhir, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D A, Tuomainen, Tomi Pekka, Peters, Sanne A E, and Bots, Michiel L.

Published
2017

19. Clustering of cardiovascular risk factors and carotid intima-media thickness : the USE-IMT study

Author

Kiechl, Stefan, Wang, Xin, Dalmeijer, Geertje W., Ruijter, Hester M. den, Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline, Engström, Gunnar, Evans, Greg W., Graaf, Jacqueline de, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kauhanen, Jussi, Kitagawa, Kazuo, Kitamura, Akihiko, Kurl, Sudhir, Lonn, Eva M., Lorenz, Matthias, Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Tuomainen, Tomi-Pekka, Peters, Sanne A. E., Bots, Michiel L., Kiechl, Stefan, Wang, Xin, Dalmeijer, Geertje W., Ruijter, Hester M. den, Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline, Engström, Gunnar, Evans, Greg W., Graaf, Jacqueline de, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kauhanen, Jussi, Kitagawa, Kazuo, Kitamura, Akihiko, Kurl, Sudhir, Lonn, Eva M., Lorenz, Matthias, Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, Polak, Joseph F., Price, Jacqueline F., Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Tuomainen, Tomi-Pekka, Peters, Sanne A. E., and Bots, Michiel L.

Abstract

Background: The relation of a single risk factor with atherosclerosis is established. Clinically we know of risk factor clustering within individuals. Yet, studies into the magnitude of the relation of risk factor clusters with atherosclerosis are limited. Here, we assessed that relation. Methods: Individual participant data from 14 cohorts, involving 59,025 individuals were used in this cross-sectional analysis. We made 15 clusters of four risk factors (current smoking, overweight, elevated blood pressure, elevated total cholesterol). Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) between clusters using those without any of the four risk factors as reference group. Results: Compared to the reference, those with 1, 2, 3 or 4 risk factors had a significantly higher common CIMT: mean difference of 0.026 mm, 0.052 mm, 0.074 mm and 0.114 mm, respectively. These findings were the same in men and in women, and across ethnic groups. Within each risk factor cluster (1, 2, 3 risk factors), groups with elevated blood pressure had the largest CIMT and those with elevated cholesterol the lowest CIMT, a pattern similar for men and women. Conclusion: Clusters of risk factors relate to increased common CIMT in a graded manner, similar in men, women and across race-ethnic groups. Some clusters seemed more atherogenic than others. Our findings support the notion that cardiovascular prevention should focus on sets of risk factors rather than individual levels alone, but may prioritize within clusters.

Published
2017

20. Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study

Author

Wang, Xin, primary, Dalmeijer, Geertje W., additional, den Ruijter, Hester M., additional, Anderson, Todd J., additional, Britton, Annie R., additional, Dekker, Jacqueline, additional, Engström, Gunnar, additional, Evans, Greg W., additional, de Graaf, Jacqueline, additional, Grobbee, Diederick E., additional, Hedblad, Bo, additional, Holewijn, Suzanne, additional, Ikeda, Ai, additional, Kauhanen, Jussi, additional, Kitagawa, Kazuo, additional, Kitamura, Akihiko, additional, Kurl, Sudhir, additional, Lonn, Eva M., additional, Lorenz, Matthias W., additional, Mathiesen, Ellisiv B., additional, Nijpels, Giel, additional, Okazaki, Shuhei, additional, Polak, Joseph F., additional, Price, Jacqueline F., additional, Rembold, Christopher M., additional, Rosvall, Maria, additional, Rundek, Tatjana, additional, Salonen, Jukka T., additional, Sitzer, Matthias, additional, Stehouwer, Coen D. A., additional, Tuomainen, Tomi-Pekka, additional, Peters, Sanne A. E., additional, and Bots, Michiel L., additional

Published
2017
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22. Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged <45 Years

Author

Eikendal, Anouk L. M., Groenewegen, Karlijn A., Anderson, Todd J., Britton, Annie R., Engstrom, Gunnar, Evans, Greg W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Dekker, Jacqueline M., Okazaki, Shuhei, O'Leary, Daniel H., Polak, Joseph F., Price, Jacqueline F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Hoefer, Imo E., Peters, Sanne A. E., Bots, Michiel L., den Ruijter, Hester M., USE-IMT Project Grp, Eikendal, Anouk L. M., Groenewegen, Karlijn A., Anderson, Todd J., Britton, Annie R., Engstrom, Gunnar, Evans, Greg W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Dekker, Jacqueline M., Okazaki, Shuhei, O'Leary, Daniel H., Polak, Joseph F., Price, Jacqueline F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Hoefer, Imo E., Peters, Sanne A. E., Bots, Michiel L., den Ruijter, Hester M., and USE-IMT Project Grp

Published
2015

23. Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged <45 Years

Author

Onderzoek Beeld, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, CDL Staf Research, CDL Arcadia, Onderzoek Vrouw Hart & Vaatziekten, Eikendal, Anouk L. M., Groenewegen, Karlijn A., Anderson, Todd J., Britton, Annie R., Engstrom, Gunnar, Evans, Greg W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Dekker, Jacqueline M., Okazaki, Shuhei, O'Leary, Daniel H., Polak, Joseph F., Price, Jacqueline F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Hoefer, Imo E., Peters, Sanne A. E., Bots, Michiel L., den Ruijter, Hester M., USE-IMT Project Grp, Onderzoek Beeld, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, CDL Staf Research, CDL Arcadia, Onderzoek Vrouw Hart & Vaatziekten, Eikendal, Anouk L. M., Groenewegen, Karlijn A., Anderson, Todd J., Britton, Annie R., Engstrom, Gunnar, Evans, Greg W., de Graaf, Jacqueline, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, Lonn, Eva M., Lorenz, Matthias W., Mathiesen, Ellisiv B., Nijpels, Giel, Dekker, Jacqueline M., Okazaki, Shuhei, O'Leary, Daniel H., Polak, Joseph F., Price, Jacqueline F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Hoefer, Imo E., Peters, Sanne A. E., Bots, Michiel L., den Ruijter, Hester M., and USE-IMT Project Grp

Published
2015

24. Race/ethnic differences in the associations of the Framingham risk factors with carotid IMT and cardiovascular events

Author

Gijsberts, Crystel M., Groenewegen, Karlijn A., Hoefer, Imo E., Eijkemans, Marinus J. C., Asselbergs, Folkert W., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline M., Engström, Gunnar, Evans, Greg W., Graaf, Jacqueline de, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, Kleijn, Dominique P. V. de, Lonn, Eva M., Lorenz, Matthias, Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, O'Leary, Daniel H., Pasterkamp, Gerard, Peters, Sanne A. E., Polak, Joseph F., Price, Jacqueline F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Bots, Michiel L., Ruijter, Hester M. den, Gijsberts, Crystel M., Groenewegen, Karlijn A., Hoefer, Imo E., Eijkemans, Marinus J. C., Asselbergs, Folkert W., Anderson, Todd J., Britton, Annie R., Dekker, Jacqueline M., Engström, Gunnar, Evans, Greg W., Graaf, Jacqueline de, Grobbee, Diederick E., Hedblad, Bo, Holewijn, Suzanne, Ikeda, Ai, Kitagawa, Kazuo, Kitamura, Akihiko, Kleijn, Dominique P. V. de, Lonn, Eva M., Lorenz, Matthias, Mathiesen, Ellisiv B., Nijpels, Giel, Okazaki, Shuhei, O'Leary, Daniel H., Pasterkamp, Gerard, Peters, Sanne A. E., Polak, Joseph F., Price, Jacqueline F., Robertson, Christine, Rembold, Christopher M., Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T., Sitzer, Matthias, Stehouwer, Coen D. A., Bots, Michiel L., and Ruijter, Hester M. den

Abstract

Background: Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and cardiovascular events. Methods: We used data from an ongoing individual participant meta-analysis involving 17 population-based cohorts worldwide. We selected 60,211 participants without cardiovascular disease at baseline with available data on ethnicity (White, Black, Asian or Hispanic). We generated a multivariable linear regression model containing risk factors and ethnicity predicting mean common carotid intima-media thickness (CIMT) and a multivariable Cox regression model predicting myocardial infarction or stroke. For each risk factor we assessed how the association with the preclinical and clinical measures of cardiovascular atherosclerotic disease was affected by ethnicity. Results: Ethnicity appeared to significantly modify the associations between risk factors and CIMT and cardiovascular events. The association between age and CIMT was weaker in Blacks and Hispanics. Systolic blood pressure associated more strongly with CIMT in Asians. HDL cholesterol and smoking associated less with CIMT in Blacks. Furthermore, the association of age and total cholesterol levels with the occurrence of cardiovascular events differed between Blacks and Whites. Conclusion: The magnitude of associations between risk factors and the presence of atherosclerotic disease differs between race/ethnic groups. These subtle, yet significant differences provide insight in the etiology of cardiovascular disease among race/ethnic groups. These insights aid the race/ethnic-specific implementation of primary prevention.

Published
2015

25. Vascular disease and cognitive function: evidence from the Whitehall II study

Author

Sing-Manoux, Archana, Britton, Annie R., and Marmot, Michael

Subjects
Cognition disorders -- Research, Cognition disorders -- Demographic aspects, Blood circulation disorders -- Research, Blood circulation disorders -- Demographic aspects, Health, Seniors
Abstract

The hypothesis of an inverse association between indicators of vascular disease and cognitive function in the stroke-free population is examined. The findings suggest that vascular disease is predictive of poor cognitive function in the general population.

Published
2003

27. Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events

Author

Gijsberts, Crystel M., primary, Groenewegen, Karlijn A., additional, Hoefer, Imo E., additional, Eijkemans, Marinus J. C., additional, Asselbergs, Folkert W., additional, Anderson, Todd J., additional, Britton, Annie R., additional, Dekker, Jacqueline M., additional, Engström, Gunnar, additional, Evans, Greg W., additional, de Graaf, Jacqueline, additional, Grobbee, Diederick E., additional, Hedblad, Bo, additional, Holewijn, Suzanne, additional, Ikeda, Ai, additional, Kitagawa, Kazuo, additional, Kitamura, Akihiko, additional, de Kleijn, Dominique P. V., additional, Lonn, Eva M., additional, Lorenz, Matthias W., additional, Mathiesen, Ellisiv B., additional, Nijpels, Giel, additional, Okazaki, Shuhei, additional, O’Leary, Daniel H., additional, Pasterkamp, Gerard, additional, Peters, Sanne A. E., additional, Polak, Joseph F., additional, Price, Jacqueline F., additional, Robertson, Christine, additional, Rembold, Christopher M., additional, Rosvall, Maria, additional, Rundek, Tatjana, additional, Salonen, Jukka T., additional, Sitzer, Matthias, additional, Stehouwer, Coen D. A., additional, Bots, Michiel L., additional, and den Ruijter, Hester M., additional

Published
2015
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28. Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged <45 Years

Author

Eikendal, Anouk L.M., primary, Groenewegen, Karlijn A., additional, Anderson, Todd J., additional, Britton, Annie R., additional, Engström, Gunnar, additional, Evans, Greg W., additional, de Graaf, Jacqueline, additional, Grobbee, Diederick E., additional, Hedblad, Bo, additional, Holewijn, Suzanne, additional, Ikeda, Ai, additional, Kitagawa, Kazuo, additional, Kitamura, Akihiko, additional, Lonn, Eva M., additional, Lorenz, Matthias W., additional, Mathiesen, Ellisiv B., additional, Nijpels, Giel, additional, Dekker, Jacqueline M., additional, Okazaki, Shuhei, additional, O’Leary, Daniel H., additional, Polak, Joseph F., additional, Price, Jacqueline F., additional, Robertson, Christine, additional, Rembold, Christopher M., additional, Rosvall, Maria, additional, Rundek, Tatjana, additional, Salonen, Jukka T., additional, Sitzer, Matthias, additional, Stehouwer, Coen D.A., additional, Hoefer, Imo E., additional, Peters, Sanne A.E., additional, Bots, Michiel L., additional, and den Ruijter, Hester M., additional

Published
2015
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29. Common Carotid Intima-Media Thickness Measurements Do Not Improve Cardiovascular Risk Prediction in Individuals With Elevated Blood Pressure

Author

Bots, Michiel L., primary, Groenewegen, Karlijn A., additional, Anderson, Todd J., additional, Britton, Annie R., additional, Dekker, Jacqueline M., additional, Engström, Gunnar, additional, Evans, Greg W., additional, de Graaf, Jacqueline, additional, Grobbee, Diederick E., additional, Hedblad, Bo, additional, Hofman, Albert, additional, Holewijn, Suzanne, additional, Ikeda, Ai, additional, Kavousi, Maryam, additional, Kitagawa, Kazuo, additional, Kitamura, Akihiko, additional, Ikram, M. Arfan, additional, Lonn, Eva M., additional, Lorenz, Matthias W., additional, Mathiesen, Ellisiv B., additional, Nijpels, Giel, additional, Okazaki, Shuhei, additional, O’Leary, Daniel H., additional, Polak, Joseph F., additional, Price, Jacqueline F., additional, Robertson, Christine, additional, Rembold, Christopher M., additional, Rosvall, Maria, additional, Rundek, Tatjana, additional, Salonen, Jukka T., additional, Sitzer, Matthias, additional, Stehouwer, Coen D.A., additional, Franco, Oscar H., additional, Peters, Sanne A.E., additional, and den Ruijter, Hester M., additional

Published
2014
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30. Sitting Behavior and Obesity

Author

Pulsford, Richard M., primary, Stamatakis, Emmanuel, additional, Britton, Annie R., additional, Brunner, Eric J., additional, and Hillsdon, Melvyn M., additional

Published
2013
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32. Sitting Behavior and Obesity Evidence from the Whitehall II Study

Author

Pulsford, Richard M., Stamatakis, Emmanuel, Britton, Annie R., Brunner, Eric J., and Hillsdon, Melvyn M.

Abstract

BackgroundProspective studies report associations between indicators of time spent sitting and obesity risk. Most studies use a single indicator of sedentary behavior and are unable to clearly identify whether sedentary behavior is a cause or a consequence of obesity.PurposeTo investigate cross-sectional and prospective associations between multiple sitting time indicators and obesity and examine the possibility of reverse causality.MethodsUsing data from the Whitehall II cohort, multiple logistic models were fitted to examine associations between prevalent obesity (BMI ≥30) at Phase 5 (1997–1999), and incident obesity between Phases 5 and 7 (2003–2004) across four levels of five sitting exposures (work sitting, TV viewing, non-TV leisure-time sitting, leisure-time sitting, and total sitting). Using obesity data from three prior phases (1985–1988, 1991–1993; and recalled weight at age 25 years), linear regression models were fitted to examine the association between prior obesity and sitting time at Phase 5. Analyses were conducted in 2012.ResultsNone of the sitting exposures were associated with obesity either cross-sectionally or prospectively. Obesity at one previous measurement phase was associated with a 2.43-hour/week (95% CI=0.07, 4.78) increase in TV viewing; obesity at three previous phases was associated with a 7.42-hour/week (95% CI=2.7, 12.46) increase in TV-viewing hours/week at Phase 5.ConclusionsSitting time was not associated with obesity cross-sectionally or prospectively. Prior obesity was prospectively associated with time spent watching TV per week but not other types of sitting.

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33. Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Wilhelmsen, Kirk C., Staessen, Jan A., Kuh, Diana, Willemsen, Gonneke, Stricker, Bruno H., Van Der Most, Peter J., Floras, John S., Penninx, Brenda, Meyer Zu Schwabedissen, Henriette, Avery, Christy L., Li, Yong, Von Der Heyde, Benedikt, Nolte, Ilja M., Laurie, Cathy C., Siscovick, David, Eskola, Markku, Krijthe, Bouwe P., Müller-Nurasyid, Martina, Stewart, James D., Zabaneh, Delilah, Kerr, Kathleen F., Ormel, Johan, Huikari, Ville, Li, Yun, Albert, Christine, Kumar, Jitender, Baker, Dewleen G., Goyette, Philippe, Kors, Jan A., Felix, Janine F., Boomsma, Dorret, Sotoodehnia, Nona, Bieringa, Rob J., Auvinen, Juha, Milaneschi, Yuri, Morris, Andrew P., Minassian, Arpi, Dierckx, Bram, Psaty, Bruce M., Hottenga, Jouke-Jan, Hassan, Mohammad, Swenne, Cees A., Mahajan, Anubha, Greiser, Halina K., Ehret, George B., Tragante, Vinicius, Kooperberg, Charles, Kiviniemi, Antti M., Gogarten, Stephanie M., Hernesniemi, Jussi, Rioux, John D., Jouven, Xavier, Lefrandt, Joop D., Salvi, Erika, Järvelin, Marjo-Riitta, Jaju, Deepali, Limacher, Marian C., Hemerich, Daiane, Hutri-Kähönen, Nina, Nikus, Kjell, Van Der Laan, Sander W., Boucher, Gabrielle, Zonderman, Alan B., Soliman, Elsayed Z., Christophersen, Ingrid E., Bis, Joshua C., Kääb, Stefan, Uitterlinden, André G., Perz, Siegfried, Kuznetsova, Tatiana, Stolarz-Skrzypek, Katarzyna, Raitakari, Olli T., Verweij, Niek, Van Roon, Arie M., Stein, Phyllis K., Stilp, Adrienne M., Hwang, Shih-Jen, Vaez, Ahmad, Risbrough, Victoria B., Oldehinkel, Albertine J., O'Donnell, Chris J., Ellinor, Patrick T., Munoz, M. Loretto, Sofer, Tamar, Maihofer, Adam X., Reiner, Alexander P., Taylor, Kent D., Huikuri, Heikki, Juonala, Markus, Wong, Andrew, Lind, Lars, Waldenberger, Melanie, Geyer, Mark A., Cusi, Daniele, Lin, Henry J., Vrijkotte, Tanja G. M., De Geus, Eco J.C., Smith, Nicholas L., Evans, Michele K., Wong, Quenna, Neijts, Melanie, Peters, Annette, Zafarmand, Mohammad H., Strauch, Konstantin, Hartman, Catharina A., Albarwani, Sulayma, Thayer, Julian F., Dietrich, Andrea, Ingelsson, Erik, Nalls, Mike A., Liao, Duanping, Bayoumi, Riad, Jansen, Rick, Lehtimäki, Terho, Lubitz, Steven A., Rotter, Jerome I., Tiemeier, Henning, Smit, Johannes H., Tinker, Lesley E., Kivimaki, Mika, Lyytikäinen, Leo-Pekka, Teumer, Alexander, McKnight, Barbara, Syvänen, Ann-Christine, Van Dongen, Jenny, Axelsson, Tomas, Brundel, Bianca J.J.M, Van Setten, Jessica, Kluttig, Alexander, Tardif, Jean-Claude, Sundström, Johan, Barcella, Matteo, Junttila, Juhani, Mononen, Nina, Ashar, Foram, Alonso, Alvaro, Thornton, Timothy A., Navis, Gerjan, Lindgren, Cecilia M., Nivard, Michel, Gademan, Maaike G. J., Den Hoed, Marcel, Van Der Harst, Pim, Sinner, Moritz F., Nievergelt, Caroline M., Kumari, Meena, Zhang, Zhu-Ming, North, Kari E., Riese, Harriëtte, Franco, Oscar H., Britton, Annie R., Hofman, Albert, Giedraitis, Vilmantas, Kähönen, Mika, Asselbergs, Folkert W., O'Connor, Daniel T., Abdellaoui, Abdel, Amare, Azmeraw T., Snieder, Harold, Voss, Andreas, Whitsel, Eric A., Friberg, Peter, Heckbert, Susan R., and De Bakker, Paul I. W.

Subjects
3. Good health
Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74

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