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Sub-optimal care of people living with dementia has serious consequences for older populations. The 2021 Australian Royal Commission noted that a large proportion of older adults in aged care live with dementia, yet there are limitations in the knowledge and understanding of staff who care for them. In the pursuit of educating pharmacists, physicians, allied health care professionals, researchers, academics, people living with dementia and their carers, and the public, who are facing the challenges of dementia management, the 'Best Practice in Dementia Health Care' conference was held on November 10, 2022 at Western Health (Sunshine Hospital, Melbourne, Australia). Sixteen experts presented on the current practice and challenges associated with delivering best practice dementia health care to older Australians, often highlighting how medication-related challenges impacted on their area of practice. Presenters highlighted the importance of individualised medication management plans, considerations of culture and Indigenous communities, the role of technology, and the impact of exercise and the physical environment on care of people living with dementia. Key clinical practice messages from each expert presenter fit into four main topics: 'navigating complexities of medication management'; 'enhancing wellbeing'; 'supportive settings and environments'; and 'programs and services improving care'. Pharmacists are crucial members of allied health care teams. They have the necessary medication and comorbidity expertise to review medication regimens, liaise with all health care providers, and provide holistic, pharmacological and non-pharmacological patient education. Towards providing best practice dementia health care, pharmacists can contribute in several ways, such as providing health practitioner education to increase understanding about medications and how they can impact on allied health practice, to ensure that medications are prescribed appropriately and safely. Further, pharmacists can make available resources to ensure people living with dementia receive culturally safe and appropriate care, while advocating for greater understanding of the history and experiences of people living with dementia to ensure care aligns with their day-to-day routines. Finally, pharmacists can provide peer-support to other health care professionals and care staff to ensure optimal management of behavioural and psychological symptoms of dementia. The information and insights shared at the conference can serve as a valuable resource for pharmacists and other health care professionals and researchers working to improve the lives of those living with dementia. [ABSTRACT FROM AUTHOR]

Summary: Mood state and alertness are negatively affected by sleep loss, and can be positively influenced by exercise. However, the potential mitigating effects of exercise on sleep‐loss‐induced changes in mood state and alertness have not been studied comprehensively. Twenty‐four healthy young males were matched into one of three, 5‐night sleep interventions: normal sleep (NS; total sleep time (TST) per night = 449 ± 22 min), sleep restriction (SR; TST = 230 ± 5 min), or sleep restriction and exercise (SR + EX; TST = 235 ± 5 min, plus three sessions of high‐intensity interval exercise (HIIE)). Mood state was assessed using the profile of mood states (POMS) and a daily well‐being questionnaire. Alertness was assessed using psychomotor vigilance testing (PVT). Following the intervention, POMS total mood disturbance scores significantly increased for both the SR and SR + EX groups, and were greater than the NS group (SR vs NS; 31.0 ± 10.7 A.U., [4.4–57.7 A.U.], p = 0.020; SR + EX vs NS; 38.6 ± 14.9 A.U., [11.1–66.1 A.U.], p = 0.004). The PVT reaction times increased in the SR (p = 0.049) and SR + EX groups (p = 0.033) and the daily well‐being questionnaire revealed increased levels of fatigue in both groups (SR; p = 0.041, SR + EX; p = 0.026) during the intervention. Despite previously demonstrated physiological benefits of performing three sessions of HIIE during five nights of sleep restriction, the detriments to mood, wellness, and alertness were not mitigated by exercise in this study. Whether alternatively timed exercise sessions or other exercise protocols could promote more positive outcomes on these factors during sleep restriction requires further research. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to independently validate a wearable inertial sensor designed to monitor training and performance metrics in swimmers. Methods: A total of 4 male (21 [4] y, 1 national and 3 international) and 6 female (22 [3] y, 1 national and 5 international) swimmers completed 15 training sessions in an outdoor 50-m pool. Swimmers were fitted with a wearable device (TritonWear, 9-axis inertial measurement unit with triaxial accelerometer, gyroscope, and magnetometer), placed under the swim cap on top of the occipital protuberance. Video footage was captured for each session to establish criterion values. Absolute error, standardized effect, and Pearson correlation coefficient were used to determine the validity of the wearable device against video footage for total swim distance, total stroke count, mean stroke count, and mean velocity. A Fisher exact test was used to analyze the accuracy of stroke-type identification. Results: Total swim distance was underestimated by the device relative to video analysis. Absolute error was consistently higher for total and mean stroke count, and mean velocity, relative to video analysis. Across all sessions, the device incorrectly detected total time spent in backstroke, breaststroke, butterfly, and freestyle by 51% (15%). The device did not detect time spent in drill. Intraclass correlation coefficient results demonstrated excellent intrarater reliability between repeated measures across all swimming metrics. Conclusions: The wearable device investigated in this study does not accurately measure distance, stroke count, and velocity swimming metrics or detect stroke type. Its use as a training monitoring tool in swimming is limited. [ABSTRACT FROM AUTHOR]

This study aimed to define, develop, and validate a subjective scale of training quality. Two related studies were used to 1) define training quality and 2) develop and validate a subjective scale. Part One: a purposive sample of 15 sub-elite (i.e. national) and elite (i.e. international) swimmers participated in one, 20-30-min semi-structured interview. Thematic analysis of interview responses established three constructs to define training quality. These were the physical, technical, and mental aspects of training. Part Two: development of the Subjective Training Quality (STQ) scale based on the three constructs identified in Part One. 252 sub-elite and elite athletes, across eight sports completed the STQ scale. Cronbach's alpha (α) assessed internal consistency, histogram plot analysis assessed face validity, and confirmatory factor analysis (CFA) compared physical, technical, and mental constructs with training quality. Root mean square error of approximation (RMSEA) and standardised root mean square residual (SRMR) evaluated CFA quality of fit. Physical, technical, and mental constructs demonstrated a high "acceptable" level of internal consistency (α = 0.85) and excellent face validity. Comparatively, the CFA quality of fit was "excellent" (RMSEA = <0.01 "good", SRMR = 0.00 "perfect"). The STQ scale demonstrated excellent internal consistency and face validity, establishing capacity to monitor training quality. The STQ scale could be used in conjunction with traditional training monitoring tools to provide additional insight into athlete's training quality. Further investigation is required to determine how the STQ scale may interact with subjective and objective training performance measures, and how it could be incorporated into daily training monitoring. Highlights Athletes perceive the subjective training quality (STQ) scale adequately represents the physical, technical, and mental constructs of training quality. Excellent internal consistency and confirmatory factor analysis fit demonstrates the STQ scale is an effective tool to monitor training quality. With additional validation, the STQ scale could be used in conjunction with traditional load monitoring tools to provide greater insight to an athlete's training response, and subsequently inform training prescription. [ABSTRACT FROM AUTHOR]

Background: One of the proposed mechanisms underlying the benefits of sports compression garments may be alterations in peripheral blood flow. Objective: We aimed to determine if sports compression garments alter measures of peripheral blood flow at rest, as well as during, immediately after and in recovery from a physiological challenge (i.e. exercise or an orthostatic challenge). Methods: We conducted a systematic literature search of databases including Scopus, SPORTDiscus and PubMed/MEDLINE. The criteria for inclusion of studies were: (1) original papers in English and a peer-reviewed journal; (2) assessed effect of compression garments on a measure of peripheral blood flow at rest and/or before, during or after a physiological challenge; (3) participants were healthy and without cardiovascular or metabolic disorders; and (4) a study population including athletes and physically active or healthy participants. The PEDro scale was used to assess the methodological quality of the included studies. A random-effects meta-analysis model was used. Changes in blood flow were quantified by standardised mean difference (SMD) [± 95% confidence interval (CI)]. Results: Of the 899 articles identified, 22 studies were included for the meta-analysis. The results indicated sports compression garments improve overall peripheral blood flow (SMD = 0.32, 95% CI 0.13, 0.51, p = 0.001), venous blood flow (SMD = 0.37, 95% CI 0.14, 0.60, p = 0.002) and arterial blood flow (SMD = 0.30, 95% CI 0.01, 0.59, p = 0.04). At rest, sports compression garments did not improve peripheral blood flow (SMD = 0.18, 95% CI − 0.02, 0.39, p = 0.08). However, subgroup analyses revealed sports compression garments enhance venous (SMD = 0.31 95% CI 0.02, 0.60, p = 0.03), but not arterial (SMD = 0.12, 95% CI − 0.16, 0.40, p = 0.16), blood flow. During a physiological challenge, peripheral blood flow was improved (SMD = 0.44, 95% CI 0.19, 0.69, p = 0.0007), with subgroup analyses revealing sports compression garments enhance venous (SMD = 0.48, 95% CI 0.11, 0.85, p = 0.01) and arterial blood flow (SMD = 0.44, 95% CI 0.03, 0.86, p = 0.04). At immediately after a physiological challenge, there were no changes in peripheral blood flow (SMD = − 0.04, 95% CI − 0.43, 0.34, p = 0.82) or subgroup analyses of venous (SMD = − 0.41, 95% CI − 1.32, 0.47, p = 0.35) and arterial (SMD = 0.12, 95% CI − 0.26, 0.51, p = 0.53) blood flow. In recovery, sports compression garments did not improve peripheral blood flow (SMD = 0.25, 95% CI − 0.45, 0.95, p = 0.49). The subgroup analyses showed enhanced venous (SMD = 0.67, 95% CI 0.17, 1.17, p = 0.009), but not arterial blood flow (SMD = 0.02, 95% CI − 1.06, 1.09, p = 0.98). Conclusions: Use of sports compression garments enhances venous blood flow at rest, during and in recovery from, but not immediately after, a physiological challenge. Compression-induced changes in arterial blood flow were only evident during a physiological challenge. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the physiological effects of compression tights on blood flow following exercise and to assess if the placebo effect is responsible for any acute performance or psychological benefits. Twenty-two resistance-trained participants completed a lower-body resistance exercise session followed by a 4 h recovery period. Participants were assigned a post-exercise recovery intervention of either compression tights applied for 4 h (COMP), placebo tablet consumed every hour for 4 h (PLA) or control (CON). Physiological (markers of venous return, muscle blood flow, blood metabolites, thigh girth), performance (countermovement jump, isometric mid-thigh pull), and psychological measures (perceived muscle soreness, total quality of recovery) were collected pre-exercise, immediately post-exercise, at 30 (markers of venous return and muscle blood flow) and 60 min (blood metabolites, thigh girth and psychological measures) intervals during 4 h of recovery, and at 4 h, 24 h and 48 h post-exercise. No significant (P > 0.05) differences were observed between interventions. However, effect size analysis revealed COMP enhanced markers of venous return, muscle blood flow, recovery of performance measures, psychological measures and reduced thigh girth compared to PLA and CON. There were no group differences in blood metabolites. These findings suggest compression tights worn after resistance exercise enhance blood flow and indices of exercise recovery, and that these benefits were not due to a placebo effect. [ABSTRACT FROM AUTHOR]

Purpose: Evidence supporting the use of lower-limb compression garments during repeated-sprint exercise (RSE) with short rest periods, where performance will rely heavily on aerobic metabolism, is lacking. Methods: A total of 20 recreationally active participants completed 2 cycling RSE sessions, with and without lower-limb compression tights. The RSE session consisted of 4 sets of 10 × 6-s maximal sprints on a wind-braked cycle ergometer, interspaced by 24 s of recovery between bouts and 2 min of recovery between sets. Muscle oxygen consumption (m V ˙ O 2 ) of, and blood flow (mBF) to, the right vastus lateralis muscle was measured during exercise using near-infrared spectroscopy and venous/arterial occlusions of the right lower limb. Cycling performance, oxygen consumption ( V ˙ O 2 ), heart rate, and capillary blood samples (lactate, pH, bicarbonate, and base excess) were also measured/taken throughout the session. Results: Compared with control, peak power (40.7 [19.9] W; mean ± 95% confidence intervals) and mBF (0.101 [0.061] mL·min−1·100 g−1) were higher, and heart rate (2 [1] beats/min) was lower, when participants wore compression (P <.05). m V ˙ O 2 , V ˙ O 2 , blood lactate, and heart rate increased as a result of exercise (P <.05), with no differences between conditions. Similarly, blood pH, bicarbonate, and base excess decreased as a result of exercise (P <.05), with no difference between conditions. Conclusions: Wearing lower-limb compression tights during RSE with short intervals of rest improved cycling performance, vastus lateralis mBF, and heart rate. These results provide novel data to support the notion that lower-limb compression garments aid RSE performance, which may be related to local and/or central blood flow. [ABSTRACT FROM AUTHOR]

Context: An athlete's ability to recover quickly is important when there is limited time between training and competition. As such, recovery strategies are commonly used to expedite the recovery process. Purpose: To determine the effectiveness of both cold-water immersion (CWI) and contrast water therapy (CWT) compared with control on short-term recovery (<4 h) after a single full-body resistance-training session. Methods: Thirteen men (age 26 ± 5 y, weight 79 ± 7 kg, height 177 ± 5 cm) were assessed for perceptual (fatigue and soreness) and performance measures (maximal voluntary isometric contraction [MVC] of the knee extensors, weighted and unweighted countermovement jumps) before and immediately after the training session. Subjects then completed 1 of three 14-min recovery strategies (CWI, CWT, or passive sitting [CON]), with the perceptual and performance measures reassessed immediately, 2 h, and 4 h postrecovery. Results: Peak torque during MVC and jump performance were significantly decreased (P < .05) after the resistance-training session and remained depressed for at least 4 h postrecovery in all conditions. Neither CWI nor CWT had any effect on perceptual or performance measures over the 4-h recovery period. Conclusions: CWI and CWT did not improve short-term (<4-h) recovery after a conventional resistance-training session. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to investigate the effectiveness of sports compression tights in reducing muscle movement and activation during running. Methods: A total of 27 recreationally active males were recruited across two separate studies. For study 1, 13 participants (mean ± SD = 84.1 ± 9.4 kg, 22 ± 3 yr) completed two 4-min treadmill running bouts (2 min at 12 and 15 km·h−1) under two conditions: a no-compression control (CON1) and compression (COMP). For study 2, 14 participants (77.8 ± 8.4 kg, 27 ± 5 yr) completed four 9-min treadmill running bouts (3 min at 8, 10, and 12 km·h−1) under four conditions: a no-compression control (CON2) and three different commercially available compression tights (2XU, Nike, and Under Armor). Using Vicon 3D motion capture technology, lower limb muscle displacement was investigated in both study 1 (thigh and calf) and study 2 (vastus lateralis + medialis [VAS]; lateral + medial gastrocnemius [GAS]). In addition, study 2 investigated the effects of compression on soft tissue vibrations (root-mean-square of resultant acceleration, RMS A r), muscle activation (iEMG), and running economy (oxygen consumption, V˙O2) during treadmill running. Results: Wearing compression during treadmill running reduced thigh and calf muscle displacement as compared with no compression (both studies), which was evident across all running speeds. Compression also reduced RMS A r and iEMG during treadmill running, but it had no effect on running economy (study 2). Conclusion: Lower limb compression garments are effective in reducing muscle displacement, soft tissue vibrations, and muscle activation associated with the impact forces experienced during running. [ABSTRACT FROM AUTHOR]

Effects of regular use of cold-water immersion (CWI) on fiber type-specific adaptations in muscle K+ transport proteins to intense training, along with their relationship to changes in mRNA levels after the first training session, were investigated in humans. Nineteen recreationally active men (24 ± 6 yr, 79.5 ± 10.8 kg, 44.6 ± 5.8 ml·kg-1·min-1) completed six weeks of sprint-interval cycling, either without (passive rest; CON) or with training sessions followed by CWI (15 min at 10°C; COLD). Muscle biopsies were obtained before and after training to determine abundance of Na+, K+-ATPase isoforms (α1-3, β1-3) and phospholemman (FXYD1) and after recovery treatments (+0 h and +3 h) on the first day of training to measure mRNA content. Training increased ( P < 0.05) the abundance of α1 and β3 in both fiber types and β1 in type-II fibers and decreased FXYD1 in type-I fibers, whereas α2 and α3 abundance was not altered by training ( P > 0.05). CWI after each session did not influence responses to training ( P > 0.05). However, α2 mRNA increased after the first session in COLD (+0 h, P < 0.05) but not in CON ( P > 0.05). In both conditions, α1 and β3 mRNA increased (+3 h; P < 0.05) and β2 mRNA decreased (+3 h; P < 0.05), whereas α3, β1, and FXYD1 mRNA remained unchanged ( P > 0.05) after the first session. In summary, Na+,K+-ATPase isoforms are differently regulated in type I and II muscle fibers by sprint-interval training in humans, which, for most isoforms, do not associate with changes in mRNA levels after the first training session. CWI neither impairs nor improves protein adaptations to intense training of importance for muscle K+ regulation. NEW & NOTEWORTHY Although cold-water immersion (CWI) after training and competition has become a routine for many athletes, limited published evidence exists regarding its impact on training adaptation. Here, we show that CWI can be performed regularly without impairing training-induced adaptations at the fiber-type level important for muscle K+ handling. Furthermore, sprint-interval training invoked fiber type-specific adaptations in K+ transport proteins, which may explain the dissociated responses of whole-muscle protein levels and K+ transport function to training previously reported. [ABSTRACT FROM AUTHOR]

Objective: Endurance runners may experience "sports anemia" resulting from intravascular hemolysis. In addition, aging has negative impact on hematopoiesis and rheological properties of blood, and erythrocyte membranes in older people are more vulnerable to oxidative damage, which together can lead to anemia. Whole-body cryostimulation (WBCST) is increasingly used in the elderly as a method of biological regeneration of athletes or therapy and preventive treatment. That is why the aim of the study was to determine whether repeated WBCST had an effect on the erythrocyte system in master marathon runners, compared to non-training men. Methods: Ten marathon runners (men aged 55.9 ± 5.5 years, training experience 6.71 ± 5.79 years) and 10 non-training (men aged 62.0 ± 5.8 years) were subjected to a series of 24 WBCST (3 min, -130°C) performed every other day. Erythrocyte levels, interleukin-3 (IL-3), erythropoietin (EPO), haptoglobin, bilirubin, and extracellular hemoglobin (HGBecf) concentrations were determined in the blood before and after 12, 24 WBCST, as well as 7 days after their completion. Results: The concentrations of EPO and IL-3 were significantly increased 7 days after the completion of WBCST in both groups (P < 0.05). The erythrocyte content and indicators, the bilirubin, haptoglobin, and HGBecf levels in each group did not change as a result of WBCST. In order to document hemolytic changes and/or factors affecting the severity of erythropoiesis, correlations between growth erythropoietic factors, erythrocyte and hemolytic factors as well as mutual correlations between hemolytic indexes were calculated. There was a positive correlation (P < 0.05) between the EPO and IL-3, bilirubin, mean corpuscular hemoglobin, and red blood cell distribution width -- standard deviation. There was also a positive correlation between the concentrations of bilirubin and HGBecf, and a negative correlation between haptoglobin and HGBecf as well as bilirubin concentrations. Conclusion: WBCST treatments, repeated every other day, do not cause hemolytic changes in elder men with high or low physical activity. But also, they are a procedure that does not increase the level of erythrocytes or their hemoglobinization. In athletes, it is not a form of doping. The positive correlation between EPO and bilirubin may be indicative of, for example, the mutual antioxidative effect of these factors. [ABSTRACT FROM AUTHOR]