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11 results on '"Brocheton, Jessy"'

2. A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1

Author

Morange, Pierre-Emmanuel, Bezemer, Irene, Saut, Noemie, Bare, Lance, Burgos, Gwenaelle, Brocheton, Jessy, Durand, Herve, Biron-Andreani, Christine, Schved, Jean-Francois, Pernod, Gilles, Galan, Pilar, Drouet, Ludovic, Zelenika, Diana, Germain, Marine, Nicaud, Viviane, Heath, Simon, Ninio, Ewa, Delluc, Aurelien, Munzel, Thomas, Zeller, Tanja, Brand-Herrmann, Stefan-Martin, Alessi, Marie-Christine, Tiret, Laurence, Lathrop, Mark, Cambien, Francois, Blankenberg, Stefan, Emmerich, Joseph, Tregouet, David-Alexandre, and Rosendaal, Frits R.

Subjects
Human genome -- Research, Single nucleotide polymorphisms -- Analysis, Genetic transcription -- Analysis, Venous thrombosis -- Genetic aspects, Biological sciences
Abstract

A multistage strategy was used to obtain strong evidence for implication of the HIVEP1 locus as a candidate for venous thrombosis (VT) risk. The results provide first evidence for the role of a genetic variant on the risk of VT outside the traditional coagulation/fibrinolysis cascade.

Published
2010

3. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

Author

Heinig, Matthias, Petretto, Enrico, Wallace, Chris, Bottolo, Leonardo, Rotival, Maxime, Lu, Han, Li, Yoyo, Sarwar, Rizwan, Langley, Sarah R., Bauerfeind, Anja, Hummel, Oliver, Lee, Young-Ae, Paskas, Svetlana, Rintisch, Carola, Saar, Kathrin, Cooper, Jason, Buchan, Rachel, Gray, Elizabeth E., Cyster, Jason G., Braund, Peter, Gracey, Jay, Krishnan, Unni, Moore, Jasbir S., Nelson, Chris P., Pollard, Helen, Attwood, Tony, Crisp-Hihn, Abi, Foad, Nicola, Jolley, Jennifer, Lloyd-Jones, Heather, Muir, David, Murray, Elizabeth, O’Leary, Karen, Rankin, Angela, Sambrook, Jennifer, Godfroy, Tiphaine, Brocheton, Jessy, Proust, Carole, Schmitz, Gerd, Heimerl, Susanne, Lugauer, Ingrid, Belz, Stephanie, Gulde, Stefanie, Linsel-Nitschke, Patrick, Sager, Hendrik, Schroeder, Laura, Lundmark, Per, Syvannen, Ann-Christine, Neudert, Jessica, Scholz, Michael, Deloukas, Panos, Gray, Emma, Gwilliams, Rhian, Niblett, David, Erdmann, Jeanette, Hengstenberg, Christian, Maouche, Seraya, Ouwehand, Willem H., Rice, Catherine M., Samani, Nilesh J., Schunkert, Heribert, Goodall, Alison H., Schulz, Herbert, Roider, Helge G., Vingron, Martin, Blankenberg, Stefan, Münzel, Thomas, Zeller, Tanja, Szymczak, Silke, Ziegler, Andreas, Tiret, Laurence, Smyth, Deborah J., Pravenec, Michal, Aitman, Timothy J., Cambien, Francois, Clayton, David, Todd, John A., Hubner, Norbert, and Cook, Stuart A.

Published
2010
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4. Powerful Identification of Cis-regulatory SNPs in Human Primary Monocytes Using Allele-Specific Gene Expression

Author

Almlöf, Jonas Carlsson, primary, Lundmark, Per, additional, Lundmark, Anders, additional, Ge, Bing, additional, Maouche, Seraya, additional, Göring, Harald H. H., additional, Liljedahl, Ulrika, additional, Enström, Camilla, additional, Brocheton, Jessy, additional, Proust, Carole, additional, Godefroy, Tiphaine, additional, Sambrook, Jennifer G., additional, Jolley, Jennifer, additional, Crisp-Hihn, Abigail, additional, Foad, Nicola, additional, Lloyd-Jones, Heather, additional, Stephens, Jonathan, additional, Gwilliam, Rhian, additional, Rice, Catherine M., additional, Hengstenberg, Christian, additional, Samani, Nilesh J., additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Pastinen, Tomi, additional, Deloukas, Panos, additional, Goodall, Alison H., additional, Ouwehand, Willem H., additional, Cambien, François, additional, and Syvänen, Ann-Christine, additional

Published
2012
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5. Correction: Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene Expression

Author

Greliche, Nicolas, primary, Zeller, Tanja, additional, Wild, Philipp S., additional, Rotival, Maxime, additional, Schillert, Arne, additional, Ziegler, Andreas, additional, Attwood, Tony, additional, Stephanie, Belz, additional, Braund, Peter, additional, Brocheton, Jessy, additional, Cooper, Jason, additional, Crisp-Hihn, Abi, additional, Diemert, Patrick (formerly Linsel-Nitschke), additional, Foad, Nicola, additional, Godefroy, Tiphaine, additional, Gracey, Jay, additional, Gray, Emma, additional, Gwilliams, Rhian, additional, Heimerl, Susanne, additional, Jolley, Jennifer, additional, Krishnan, Unni, additional, Lloyd-Jones, Heather, additional, Liljedahl, Ulrika, additional, Lugauer, Ingrid, additional, Lundmark, Per, additional, Maouche, Seraya, additional, Moore, Jasbir S, additional, Gilles, Montalescot, additional, Muir, David, additional, Murray, Elizabeth, additional, Nelson, Chris P, additional, Neudert, Jessica, additional, Niblett, David, additional, O.Leary, Karen, additional, Pollard, Helen, additional, Proust, Carole, additional, Rankin, Angela, additional, Rendon, Augusto, additional, Rice, Catherine M, additional, Sager, Hendrik, additional, Sambrook, Jennifer, additional, Gerd, Schmitz, additional, Scholz, Michael, additional, Schroeder, Laura, additional, Stephens, Jonathan, additional, Syvannen, Ann-Christine, additional, Tennstedt, Stefanie (formerlyGulde), additional, and Wallace, Chris, additional

Published
2012
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7. Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

Author

Rotival, Maxime, primary, Zeller, Tanja, additional, Wild, Philipp S., additional, Maouche, Seraya, additional, Szymczak, Silke, additional, Schillert, Arne, additional, Castagné, Raphaele, additional, Deiseroth, Arne, additional, Proust, Carole, additional, Brocheton, Jessy, additional, Godefroy, Tiphaine, additional, Perret, Claire, additional, Germain, Marine, additional, Eleftheriadis, Medea, additional, Sinning, Christoph R., additional, Schnabel, Renate B., additional, Lubos, Edith, additional, Lackner, Karl J., additional, Rossmann, Heidi, additional, Münzel, Thomas, additional, Rendon, Augusto, additional, Consortium, Cardiogenics, additional, Erdmann, Jeanette, additional, Deloukas, Panos, additional, Hengstenberg, Christian, additional, Diemert, Patrick, additional, Montalescot, Gilles, additional, Ouwehand, Willem H., additional, Samani, Nilesh J., additional, Schunkert, Heribert, additional, Tregouet, David-Alexandre, additional, Ziegler, Andreas, additional, Goodall, Alison H., additional, Cambien, François, additional, Tiret, Laurence, additional, and Blankenberg, Stefan, additional

Published
2011
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8. Critical Role of cRel Subunit of NF-κB in Sepsis Survival

Author

Courtine, Emilie, primary, Pène, Frédéric, additional, Cagnard, Nicolas, additional, Toubiana, Julie, additional, Fitting, Catherine, additional, Brocheton, Jessy, additional, Rousseau, Christophe, additional, Gerondakis, Steve, additional, Chiche, Jean-Daniel, additional, Ouaaz, Fatah, additional, and Mira, Jean-Paul, additional

Published
2011
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9. Gene Expression Signature in Peripheral Blood Cells Detects Intracranial Aneurysm

Author

Yilmaz, Saliha, primary, Bijlenga, Philippe, additional, Rashid, Mamunur, additional, Collot-Teixeira, Sophie, additional, Brocheton, Jessy, additional, Proust, Carole, additional, Rotival, Maxime, additional, Risselada, Roelof, additional, Summers, Paul, additional, Blasco, J., additional, Singh, J., additional, Waterworth, Alan, additional, Ebeling, Christian, additional, Friedrich, Christoph, additional, Frangi, A. F., additional, Macho, J. J., additional, Byrne, J., additional, Sturkenboom, M. C.J.M., additional, Schaller, K., additional, Cambien, Francois, additional, Gunel, Murat, additional, and McGregor, John Louis, additional

Published
2010
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10. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips.

Author

Baudoin, Régis, Prot, Jean Matthieu, Nicolas, Grégory, Brocheton, Jessy, Brochot, Céline, Legallais, Cécile, Benech, Henri, and Leclerc, Eric

Subjects
CRYOPRESERVATION of organs, tissues, etc., BIOCHIPS, MESSENGER RNA, DRUG metabolism, PHARMACOKINETICS, PERFUSION
Abstract

We present characterization of the metabolic performance of human cryopreserved hepatocytes cultivated in a platform of parallelized microfluidic biochips. The RTqPCR analysis revealed that the mRNA levels of the cytochromes P450 (CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4) were reduced after the adhesion period (when compared to the post-thawing step). The microfluidic perfusion played a part in stabilizing and partially recovering the levels of the HNF4α, PXR, OAPT2, CYP 1A2, 2B6, 2C19 and 3A4 mRNA on contrary to non-perfused cultures. Fluorescein diacetate staining and P-gp mRNA level illustrated the hepatocytes' polarity in the biochips. Drug metabolism was assessed using midazolam, tolbutamide, caffeine, omeprazole, dextromethorphan, acetaminophen and repaglinide as probes. Metabolite detection and quantification revealed that CYP1A2 (via the detection of paraxanthine), CYP3A4 (via 1-OH-midazolam, and omeprazole sulfone detection), CYP2C8 (via hydroxyl-repaglinide detection), CYP2C19 (via hydroxy-omeprazole detection) and CYP2D6 (via dextrorphan detection) were functional in our microfluidic configurations. Furthermore, the RTqPCR analysis showed that the drugs acted as inductors leading to overexpression of mRNA levels when compared to post-thawing values (such as for HNF4α, PXR and CYP3A4 by dextromethorpahn and omeprazole). Finally, intrinsic in vitro biochip clearances were extracted using a PBPK model for predictions. The biochip predictions were compared to literature in vitro data and in vivo situations. [ABSTRACT FROM AUTHOR]

Published
2013
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11. Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes.

Author

Garnier, Sophie, Truong, Vinh, Brocheton, Jessy, Zeller, Tanja, Rovital, Maxime, Wild, Philipp S., Ziegler, Andreas, Munzel, Thomas, Tiret, Laurence, Blankenberg, Stefan, Deloukas, Panos, Erdmann, Jeannette, Hengstenberg, Christian, Samani, Nilesh J., Schunkert, Heribert, Ouwehand, Willem H., Goodall, Alison H., Cambien, François, and Trégouët, David-Alexandre

Abstract

In order to assess whether gene expression variability could be influenced by several SNPs acting in cis, either through additive or more complex haplotype effects, a systematic genome-wide search for cis haplotype expression quantitative trait loci (eQTL) was conducted in a sample of 758 individuals, part of the Cardiogenics Transcriptomic Study, for which genome-wide monocyte expression and GWAS data were available. 19,805 RNA probes were assessed for cis haplotypic regulation through investigation of ~2,1×109 haplotypic combinations. 2,650 probes demonstrated haplotypic p-values >104-fold smaller than the best single SNP p-value. Replication of significant haplotype effects were tested for 412 probes for which SNPs (or proxies) that defined the detected haplotypes were available in the Gutenberg Health Study composed of 1,374 individuals. At the Bonferroni correction level of 1.2×10−4 (~0.05/412), 193 haplotypic signals replicated. 1000G imputation was then conducted, and 105 haplotypic signals still remained more informative than imputed SNPs. In-depth analysis of these 105 cis eQTL revealed that at 76 loci genetic associations were compatible with additive effects of several SNPs, while for the 29 remaining regions data could be compatible with a more complex haplotypic pattern. As 24 of the 105 cis eQTL have previously been reported to be disease-associated loci, this work highlights the need for conducting haplotype-based and 1000G imputed cis eQTL analysis before commencing functional studies at disease-associated loci. [ABSTRACT FROM AUTHOR]

Published
2013
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