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444 results on '"Brodowicz, T."'

2. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Blay, J.Y., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dufresne, A., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S.J., Hall, K Sundby, Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Gronchi, A., and Stacchiotti, S.

Published
2022
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3. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

Author

Strauss, S.J., Frezza, A.M., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., de Álava, E., Dei Tos, A.P., Garcia del Muro, X., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Gaspar, N., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Gronchi, A., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., López Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Ladenstein, R., Casali, P.G., and Stacchiotti, S.

Published
2021
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4. Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

Author

Gronchi, A., Miah, A.B., Dei Tos, A.P., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., De Álava, E., Del Muro, X.G., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Casali, P.G., and Stacchiotti, S.

Published
2021
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5. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Author

Stacchiotti, S., Miah, A.B., Frezza, A.M., Messiou, C., Morosi, C., Caraceni, A., Antonescu, C.R., Bajpai, J., Baldini, E., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Callegaro, D., De Alava, E., Deoras-Sutliff, M., Dufresne, A., Eriksson, M., Errani, C., Fedenko, A., Ferraresi, V., Ferrari, A., Fletcher, C.D.M., Garcia del Muro, X., Gelderblom, H., Gladdy, R.A., Gouin, F., Grignani, G., Gutkovich, J., Haas, R., Hindi, N., Hohenberger, P., Huang, P., Joensuu, H., Jones, R.L., Jungels, C., Kasper, B., Kawai, A., Le Cesne, A., Le Grange, F., Leithner, A., Leonard, H., Lopez Pousa, A., Martin Broto, J., Merimsky, O., Merriam, P., Miceli, R., Mir, O., Molinari, M., Montemurro, M., Oldani, G., Palmerini, E., Pantaleo, M.A., Patel, S., Piperno-Neumann, S., Raut, C.P., Ravi, V., Razak, A.R.A., Reichardt, P., Rubin, B.P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sapisochin, G., Sbaraglia, M., Scheipl, S., Schöffski, P., Strauss, D., Strauss, S.J., Sundby Hall, K., Tap, W.D., Trama, A., Tweddle, A., van der Graaf, W.T.A., Van De Sande, M.A.J., Van Houdt, W., van Oortmerssen, G., Wagner, A.J., Wartenberg, M., Wood, J., Zaffaroni, N., Zimmermann, C., Casali, P.G., Dei Tos, A.P., and Gronchi, A.

Published
2021
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6. Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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7. Bone sarcomas: ESMO–PaedCan–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Bielack, S., Abecassis, N., Aro, H.T., Bauer, S., Biagini, R., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brennan, B., Brodowicz, T., Broto, J.M., Brugières, L., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Dhooge, C., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gaspar, N., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hassan, B., Hecker-Nolting, S., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kager, L., Kasper, B., Kopeckova, K., Krákorová, D.A., Ladenstein, R., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Morland, B., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Strauss, S.J., Sundby Hall, K., Unk, M., Van Coevorden, F., van der Graaf, W.T.A., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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8. Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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22. Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, Paolo G., Blay, Jean-Yves, Abecassis, N., Bajpai, J., Bauer, Sebastian, Biagini, R., Bielack, S., Bonvalot, Sylvie, Boukovinas, I., Bovee, J. V. M. G., Boye, K., Brodowicz, T., Buonadonna, A., Álava, Enrique de, Tos, A. P. dei, García del Muro, Xavier, Dufresne, Armelle, Eriksson, Mikael, Fedenko, Alexander, Ferraresi, Virginia, Ferrari, A., Frezza, Anna M., Gasperoni, Silvia, Gelderblom, Hans, Gouin, Francois, Grignani, Giovanni, Haas, R. L., Hassan, A. B., Hindi, Nadia, Hohenberger, Peter, Joensuu, Heikki, Jones, Robin L., Jungels, C., Jutte, P., Kasper, Bernd, Kawai, Akira, Kopeckova, K., Krákorová, D. A., Le Cesne, A, Le Grange, F, Legius, E., Leithner, Andreas, López-Pousa, Antonio, Martín-Broto, Javier, Merimsky, O., Messiou, C., Miah, A. B., Mir, Olivier, Montemurro, M., Morosi, Carlo, Palmerini, Emanuela, Pantaleo, M. A., Piana, R., Piperno-Neumann, S., Reichardt, Peter, Rutkowski, Piotr, Safwat, A. A., Sangalli, C., Sbaraglia, Marta, Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S. J., Sundby-Hall, Kirsten, Trama, A., Unk, M., Sande, M. A. J. van de, Graaf, W.T.A. van der, Houdt, W. J. van, Frebourg, T., Gronchi, Alesandro, Stacchiotti, Silvia, ESMO Guidelines Committee, EURACAN, GENTURIS, Casali, Paolo G., Blay, Jean-Yves, Abecassis, N., Bajpai, J., Bauer, Sebastian, Biagini, R., Bielack, S., Bonvalot, Sylvie, Boukovinas, I., Bovee, J. V. M. G., Boye, K., Brodowicz, T., Buonadonna, A., Álava, Enrique de, Tos, A. P. dei, García del Muro, Xavier, Dufresne, Armelle, Eriksson, Mikael, Fedenko, Alexander, Ferraresi, Virginia, Ferrari, A., Frezza, Anna M., Gasperoni, Silvia, Gelderblom, Hans, Gouin, Francois, Grignani, Giovanni, Haas, R. L., Hassan, A. B., Hindi, Nadia, Hohenberger, Peter, Joensuu, Heikki, Jones, Robin L., Jungels, C., Jutte, P., Kasper, Bernd, Kawai, Akira, Kopeckova, K., Krákorová, D. A., Le Cesne, A, Le Grange, F, Legius, E., Leithner, Andreas, López-Pousa, Antonio, Martín-Broto, Javier, Merimsky, O., Messiou, C., Miah, A. B., Mir, Olivier, Montemurro, M., Morosi, Carlo, Palmerini, Emanuela, Pantaleo, M. A., Piana, R., Piperno-Neumann, S., Reichardt, Peter, Rutkowski, Piotr, Safwat, A. A., Sangalli, C., Sbaraglia, Marta, Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S. J., Sundby-Hall, Kirsten, Trama, A., Unk, M., Sande, M. A. J. van de, Graaf, W.T.A. van der, Houdt, W. J. van, Frebourg, T., Gronchi, Alesandro, Stacchiotti, Silvia, ESMO Guidelines Committee, EURACAN, and GENTURIS

Abstract

Gastrointestinal stromal tumours (GISTs) are malignant mesenchymal tumours with a variable clinical behaviour, marked by differentiation towards the interstitial cells of Cajal.1 GISTs belong to the family of soft tissue sarcomas (STSs) but are treated separately due to their peculiar histogenesis, clinical behaviour and specific therapy. This European Society for Medical Oncology (ESMO)–European Reference Network for Rare Adult Solid Cancers (EURACAN)–European Reference Network for Genetic Tumour Risk Syndromes (GENTURIS) Clinical Practice Guideline (CPG) will cover GISTs while other STSs are covered in the ESMO–EURACAN–European Reference Network for Paediatric Oncology (ERN PaedCan)–GENTURIS STS CPG.

Published
2022

24. 415P Comparison of cetuximab every 2 weeks versus standard once-weekly administration for the first-line treatment of RAS wild-type metastatic colorectal cancer among patients with left- and right-sided primary tumor location

Author

Kasper, S., primary, Cheng, A-L., additional, Rouyer, M., additional, Foch, C., additional, Lamy, F-X., additional, Esser, R., additional, Batech, M., additional, Wong, C.M.J., additional, Zhang, A., additional, Brodowicz, T., additional, and Zielinski, C., additional

Published
2021
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25. P-52 Overall survival with cetuximab every 2 weeks vs standard once-weekly administration schedule for first-line treatment of RAS wild-type metastatic colorectal cancer in patients with left- and right-sided primary tumor location

Author

Kasper, S., primary, Cheng, A., additional, Rouyer, M., additional, Foch, C., additional, Lamy, F., additional, Esser, R., additional, Batech, M., additional, Wong, C., additional, Zhang, A., additional, Brodowicz, T., additional, and Zielinski, C., additional

Published
2021
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26. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

Author

European Society for Medical Oncology, Strauss, S. J., Frezza, Anna M., Abecassis, N., Bajpai, J., Bauer, Sebastian, Biagini, R., Bielack, S., Blay, Jean-Yves, Bolle, S., Bonvalot, Sylvie, Boukovinas, I., Bovee, J. V. M. G., Boye, K., Brennan, Bernadette, Brodowicz, T., Buonadonna, A., Álava, Enrique de, Dei Tos, Angelo Paolo, García del Muro, Xavier, Dufresne, Armelle, Eriksson, Mikael, Fagioli, F., Fedenko, Alexander, Ferraresi, Virginia, Ferrari, A., Gaspar, Nathalie, Gasperoni, Silvia, Gelderblom, Hans, Gouin, Francois, Grignani, Giovanni, Gronchi, Alesandro, Haas, R. L., Hassan, A. B., Hecker-Nolting, S., Hindi, Nadia, Hohenberger, Peter, Joensuu, Heikki, Jones, Robin L., Jungels, C., Jutte, P., Kager, L., Kasper, Bernd, Kawai, Akira, Kopeckova, K., Krákorová, D. A., Le Cesne, Axel, Le Grange, F., Legius, E., Leithner, Andreas, López-Pousa, Antonio, Martín-Broto, Javier, Merimsky, O., Messiou, C., Miah, A. B., Mir, Olivier, Montemurro, M., Morland, B., Morosi, Carlo, Palmerini, Emanuela, Pantaleo, M. A., Piana, R., Piperno-Neumann, S., Reichardt, Peter, Rutkowski, Piotr, Safwat, A. A., Sangalli, C., Sbaraglia, Marta, Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Sundby Hall, K., Trama, A., Unk, M., van de Sande, Michiel, van der Graaf, W. T., van Houdt, W. J., Frebourg, T., Ladenstein, Rudolf, Casali, Paolo G., Stacchiotti, Silvia, European Society for Medical Oncology, Strauss, S. J., Frezza, Anna M., Abecassis, N., Bajpai, J., Bauer, Sebastian, Biagini, R., Bielack, S., Blay, Jean-Yves, Bolle, S., Bonvalot, Sylvie, Boukovinas, I., Bovee, J. V. M. G., Boye, K., Brennan, Bernadette, Brodowicz, T., Buonadonna, A., Álava, Enrique de, Dei Tos, Angelo Paolo, García del Muro, Xavier, Dufresne, Armelle, Eriksson, Mikael, Fagioli, F., Fedenko, Alexander, Ferraresi, Virginia, Ferrari, A., Gaspar, Nathalie, Gasperoni, Silvia, Gelderblom, Hans, Gouin, Francois, Grignani, Giovanni, Gronchi, Alesandro, Haas, R. L., Hassan, A. B., Hecker-Nolting, S., Hindi, Nadia, Hohenberger, Peter, Joensuu, Heikki, Jones, Robin L., Jungels, C., Jutte, P., Kager, L., Kasper, Bernd, Kawai, Akira, Kopeckova, K., Krákorová, D. A., Le Cesne, Axel, Le Grange, F., Legius, E., Leithner, Andreas, López-Pousa, Antonio, Martín-Broto, Javier, Merimsky, O., Messiou, C., Miah, A. B., Mir, Olivier, Montemurro, M., Morland, B., Morosi, Carlo, Palmerini, Emanuela, Pantaleo, M. A., Piana, R., Piperno-Neumann, S., Reichardt, Peter, Rutkowski, Piotr, Safwat, A. A., Sangalli, C., Sbaraglia, Marta, Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Sundby Hall, K., Trama, A., Unk, M., van de Sande, Michiel, van der Graaf, W. T., van Houdt, W. J., Frebourg, T., Ladenstein, Rudolf, Casali, Paolo G., and Stacchiotti, Silvia

Published
2021

32. Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P G, Abecassis, N, Aro, H T, Bauer, S, Biagini, R, Bielack, S, Bonvalot, S, Boukovinas, I, Bovee, J V M G, Brodowicz, T, Broto, J M, Buonadonna, A, De Álava, E, Dei Tos, A P, Del Muro, X G, Dileo, P, Eriksson, M, Fedenko, A, Ferraresi, V, Ferrari, A, Ferrari, S, Frezza, A M, Gasperoni, S, Gelderblom, H, Gil, T, Grignani, G, Gronchi, A, Haas, R L, Hassan, B, Hohenberger, P, Issels, R, Joensuu, H, Jones, R L, Judson, I, Jutte, P, Kaal, S, Kasper, B, Kopeckova, K, Krákorová, D A, Le Cesne, A, Lugowska, I, Merimsky, O, Montemurro, M, Pantaleo, M A, Piana, R, Picci, P, Piperno-Neumann, S, Pousa, A L, Reichardt, P, and Safwat, A A

Published
2018
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33. Prior exposure to pazopanib (PAZ) did not minor efficacy of regorafenib (REG) in non-adipocytic soft tissue sarcoma patients (pts)

Author

Penel, N., primary, Blay, J.-Y., additional, Wallet, J., additional, Mir, O., additional, Italiano, A., additional, Bertucci, F., additional, Piperno-Neumann, S., additional, Brodowicz, T., additional, Bompas, E., additional, Liegl-Atzwanger, B., additional, Chevreau, C.M., additional, Ray-Coquard, I.L., additional, Taieb, S., additional, Decoupigny, E., additional, Deley, M C Le, additional, and Le Cesne, A., additional

Published
2019
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34. Noninferiority on overall survival of every-2-weeks vs weekly schedule of cetuximab for first-line treatment of RAS wild-type metastatic colorectal cancer

Author

Kasper, S., primary, Cheng, A.-L., additional, Overkamp, F., additional, Rouyer, M., additional, Foch, C., additional, Lamy, F.-X., additional, Esser, R., additional, Messinger, D., additional, Rothe, V., additional, Chen, W., additional, Brodowicz, T., additional, and Zielinski, C.C., additional

Published
2019
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39. Regosarc: regorafenib versus placebo in doxorubicin-refractory soft-tissue sarcoma-a quality-adjusted time without symptoms of progression or toxicity analysis

Author

Berry, V. (Vincent), Basson, L. (Laurent), Bogart, E. (Emilie), Mir, O. (Olivier), Blay, J-Y. (Jean-Yves), Italiano, A. (Antoine), Bertucci, F. (François), Chevreau, C. (Christine), Clisant-Delaine, S. (Stephanie), Liegl-Atzwanger, B. (Bernadette), Tresch-Bruneel, E. (Emmanuelle), Wallet, J. (Jennifer), Taieb, S. (Sophie), Decoupigny, E. (Emilie), Le Cesne, A. (Axel), Brodowicz, T. (Thomas), Penel, N. (Nicolas), Site de Recherche Intégrée en Cancérologie (SIRIC-ONCOLille), Université de Lille, Sciences et Technologies-Université de Lille, Sciences Humaines et Sociales-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER-Université de Lille-UNICANCER-Cancéropole Nord-Ouest-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Institut Gustave Roussy (IGR), Centre Léon Bérard [Lyon], Institut Bergonié [Bordeaux], UNICANCER, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Claudius Regaud, Karl-Franzens-Universität Graz, University of Vienna [Vienna], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Cancéropole Nord-Ouest-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille Nord de France (COMUE)-UNICANCER, Karl-Franzens-Universität [Graz, Autriche], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, CHU Lille, Université de Lille, Site de Recherche Intégrée en Cancérologie [SIRIC-ONCOLille], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Institut Gustave Roussy [IGR], and Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Subjects
[SDV]Life Sciences [q-bio], Mesh:Diarrhea/chemically induced, Mesh:Alopecia/chemically induced, Mesh:Phenylurea Compounds/therapeutic use, Mesh:Aged, Mesh:Synovial/drug therapy, Mesh:Treatment Outcome, Mesh:Anorexia/chemically induced, Mesh:Quality of Life, Mesh:Proportional Hazards Models, Mesh:Severity of Illness Index, Mesh:Female, quality-adjusted survival, Mesh:Fecal Incontinence/chemically induced, Mesh:Male, Mesh:Sarcoma, Mesh:Middle Aged, quality-adjusted time without symptoms of progression or toxicity (Q-TWiST), Mesh:Asthenia/chemically induced, Mesh:Liposarcoma/drug therapy, metastatic soft-tissue sarcoma, placebo, regorafenib, Mesh:Mucositis/chemically induced, Mesh:Hospitalization, Mesh:Sarcoma/drug therapy, Mesh:Hand-Foot Syndrome/etiology, Mesh:Pyridines/therapeutic use, Mesh:Antineoplastic Agents/therapeutic use, Mesh:Leiomyosarcoma/drug therapy, Mesh:Humans, Mesh:Hypertension/chemically induced, Mesh:Double-Blind Method
Abstract

International audience; BACKGROUND: In a placebo-controlled, randomized phase 2 trial (ClinicalTrials.gov identifier NCT01900743), regorafenib improved progression-free survival (PFS) for patients with doxorubicin-pretreated advanced nonadipocytic sarcoma. A quality-adjusted time without symptoms of progression or toxicity (Q-TWiST) post hoc exploratory analysis was applied to provide an integrated measure of its clinical benefit.METHODS: In the base-case analysis, each patient's overall survival (OS) was partitioned into 3 mutually exclusive health states: the time with a grade 3 or 4 adverse event (TOX), the time without symptoms of disease or grade 3 or 4 toxicity from treatment, and the time after tumor progression or relapse. The time spent in each state was weighted with a health-state utility associated with that state and was summed to calculate the Q-TWiST. The stability of the base-case analysis was explored with several sensitivity analyses.RESULTS: In nonadipocytic sarcoma, the PFS was (4.0 months [2.6-5.5 months] with regorafenib vs 1.0 month [0.9-1.8 months] with a placebo; hazard ratio, 0.36 [0.25-0.53]; P < .0001); the OS was 13.4 months (8.6-17.3 months) with regorafenib and 9.0 months (6.8-12.5 months) with a placebo (hazard ratio, 0.67 [0.44-1.02]). With the classic definition of TOX (including all grade 3 and 4 clinical adverse events), the Q-TWiSTs were 8.0 months (7.0-9.0 months) with regorafenib and 5.7 months (4.9-6.4 months) with a placebo (P

Published
2017
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41. Corrections to “Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Casali, P.G., primary, Abecassis, N., additional, Aro, H.T., additional, Bauer, S., additional, Biagini, R., additional, Bielack, S., additional, Bonvalot, S., additional, Boukovinas, I., additional, Bovee, J V M G, additional, Brodowicz, T., additional, Broto, J.M., additional, Buonadonna, A., additional, De Álava, E., additional, Dei Tos, A.P., additional, Del Muro, X.G., additional, Dileo, P., additional, Eriksson, M., additional, Fedenko, A., additional, Ferraresi, V., additional, Ferrari, A., additional, Ferrari, S., additional, Frezza, A.M., additional, Gasperoni, S., additional, Gelderblom, H., additional, Gil, T., additional, Grignani, G., additional, Gronchi, A., additional, Haas, R.L., additional, Hassan, B., additional, Hohenberger, P., additional, Issels, R., additional, Joensuu, H., additional, Jones, R.L., additional, Judson, I., additional, Jutte, P., additional, Kaal, S., additional, Kasper, B., additional, Kopeckova, K., additional, Krákorová, D.A., additional, Le Cesne, A., additional, Lugowska, I., additional, Merimsky, O., additional, Montemurro, M., additional, Pantaleo, M.A., additional, Piana, R., additional, Picci, P., additional, Piperno-Neumann, S., additional, Pousa, A.L., additional, Reichardt, P., additional, Robinson, M.H., additional, Rutkowski, P., additional, Safwat, A.A., additional, Schöffski, P., additional, Sleijfer, S., additional, Stacchiotti, S., additional, Sundby Hall, K., additional, Unk, M., additional, Van Coevorden, F., additional, van der Graaf, W.T.A., additional, Whelan, J., additional, Wardelmann, E., additional, Zaikova, O., additional, and Blay, J.Y., additional

Published
2018
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42. Corrections to “Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Casali, P.G., primary, Abecassis, N., additional, Aro, H.T., additional, Bauer, S., additional, Biagini, R., additional, Bielack, S., additional, Bonvalot, S., additional, Boukovinas, I., additional, Bovee, J V M G, additional, Brodowicz, T., additional, Broto, J.M., additional, Buonadonna, A., additional, De Álava, E., additional, Dei Tos, A.P., additional, Del Muro, X.G., additional, Dileo, P., additional, Eriksson, M., additional, Fedenko, A., additional, Ferraresi, V., additional, Ferrari, A., additional, Ferrari, S., additional, Frezza, A.M., additional, Gasperoni, S., additional, Gelderblom, H., additional, Gil, T., additional, Grignani, G., additional, Gronchi, A., additional, Haas, R.L., additional, Hassan, B., additional, Hohenberger, P., additional, Issels, R., additional, Joensuu, H., additional, Jones, R.L., additional, Judson, I., additional, Jutte, P., additional, Kaal, S., additional, Kasper, B., additional, Kopeckova, K., additional, Krákorová, D.A., additional, Le Cesne, A., additional, Lugowska, I., additional, Merimsky, O., additional, Montemurro, M., additional, Pantaleo, M.A., additional, Piana, R., additional, Picci, P., additional, Piperno-Neumann, S., additional, Pousa, A.L., additional, Reichardt, P., additional, Robinson, M.H., additional, Rutkowski, P., additional, Safwat, A.A., additional, Schöffski, P., additional, Sleijfer, S., additional, Stacchiotti, S., additional, Sundby Hall, K., additional, Unk, M., additional, Van Coevorden, F., additional, van der Graaf, W.T.A., additional, Whelan, J., additional, Wardelmann, E., additional, Zaikova, O., additional, and Blay, J.Y., additional

Published
2018
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43. Bone sarcomas: ESMO–PaedCan–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, Paolo G., Bielack, S., Abecassis, N., Aro, H. T., Bauer, Sebastian, Biagini, R., Bonvalot, Sylvie, Boukovinas, I., Bovee, J. V. M. G., Brennan, Bernadette, Brodowicz, T., Martín-Broto, Javier, Brugières, L., Buonadonna, A., Álava, Enrique de, Dei Tos, Angelo Paolo, García del Muro, Xavier, Dileo, P., Dhooge, C., Eriksson, Mikael, Fagioli, F., Fedenko, Alexander, Ferraresi, Virginia, Ferrari, A., Frezza, Anna M., Gaspar, Nathalie, Gasperoni, Silvia, Gelderblom, Hans, Gil, T., Grignani, Giovanni, Gronchi, Alesandro, Haas, R. L., Hassan, B., Hecker-Nolting, S., Hohenberger, Peter, Issels, R., Joensuu, Heikki, Jones, Robin L., Judson, I., Jutte, P., Kaal, S., Kager, L., Kasper, Bernd, Kopeckova, K., Krákorová, D. A., Ladenstein, Rudolf, Le Cesne, Axel, Lugowska, Iwona, Merimsky, O., Montemurro, M., Morland, B., Pantaleo, M. A., Piana, R., Picci, Piero, Piperno-Neumann, S., Pousa, A. L., Reichardt, Peter, Robinson, M. H., Rutkowski, Piotr, Safwat, A. A., Schöffski, P., Sleijfer, S., Stacchiotti, Silvia, Strauss, Sandra, Sundby Hall, K., Unk, M., van Coevorden, F., van der Graaf, W. T., Whelan, Jeremy, Wardelmann, Eva, Zaikova, O., Blay, Jean-Yves, Casali, Paolo G., Bielack, S., Abecassis, N., Aro, H. T., Bauer, Sebastian, Biagini, R., Bonvalot, Sylvie, Boukovinas, I., Bovee, J. V. M. G., Brennan, Bernadette, Brodowicz, T., Martín-Broto, Javier, Brugières, L., Buonadonna, A., Álava, Enrique de, Dei Tos, Angelo Paolo, García del Muro, Xavier, Dileo, P., Dhooge, C., Eriksson, Mikael, Fagioli, F., Fedenko, Alexander, Ferraresi, Virginia, Ferrari, A., Frezza, Anna M., Gaspar, Nathalie, Gasperoni, Silvia, Gelderblom, Hans, Gil, T., Grignani, Giovanni, Gronchi, Alesandro, Haas, R. L., Hassan, B., Hecker-Nolting, S., Hohenberger, Peter, Issels, R., Joensuu, Heikki, Jones, Robin L., Judson, I., Jutte, P., Kaal, S., Kager, L., Kasper, Bernd, Kopeckova, K., Krákorová, D. A., Ladenstein, Rudolf, Le Cesne, Axel, Lugowska, Iwona, Merimsky, O., Montemurro, M., Morland, B., Pantaleo, M. A., Piana, R., Picci, Piero, Piperno-Neumann, S., Pousa, A. L., Reichardt, Peter, Robinson, M. H., Rutkowski, Piotr, Safwat, A. A., Schöffski, P., Sleijfer, S., Stacchiotti, Silvia, Strauss, Sandra, Sundby Hall, K., Unk, M., van Coevorden, F., van der Graaf, W. T., Whelan, Jeremy, Wardelmann, Eva, Zaikova, O., and Blay, Jean-Yves

Published
2018

44. EORTC experience with advanced/metastatic epithelioid sarcoma patients treated in prospective trials: Clinical profile and response to systemic therapy

Author

Touati, N., primary, Schoffski, P., additional, Litière, S., additional, Judson, I., additional, Sleijfer, S., additional, van der Graaf, W.T.A., additional, Italiano, A., additional, Isambert, N., additional, Gil, T., additional, Blay, J.-Y., additional, Stark, D., additional, Brodowicz, T., additional, Marreaud, S., additional, and Gronchi, A., additional

Published
2017
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47. Third CECOG consensus on the systemic treatment of non-small-cell lung cancer

Author

Brodowicz, T., Ciuleanu, T., Crawford, J., Filipits, M., Fischer, J. R., Georgoulias, V., Gridelli, C., Hirsch, F. R., Jassem, J., Kosmidis, P., Krzakowski, M., Manegold, Ch, Pujol, J. L., Stahel, R., Thatcher, N., Vansteenkiste, J., Minichsdorfer, C., Zöchbauer-Müller, S., Pirker, R., Zielinski, C. C., Brodowicz, T., Ciuleanu, T., Crawford, J., Filipits, M., Fischer, J. R., Georgoulias, V., Gridelli, C., Hirsch, F. R., Jassem, J., Kosmidis, P., Krzakowski, M., Manegold, Ch, Pujol, J. L., Stahel, R., Thatcher, N., Vansteenkiste, J., Minichsdorfer, C., Zöchbauer-Müller, S., Pirker, R., and Zielinski, C. C.

Abstract

The current third consensus on the systemic treatment of non-small-cell lung cancer (NSCLC) builds upon and updates similar publications on the subject by the Central European Cooperative Oncology Group (CECOG), which has published such consensus statements in the years 2002 and 2005 (Zielinski CC, Beinert T, Crawford J et al. Consensus on medical treatment of non-small-cell lung cancer—update 2004. Lung Cancer 2005; 50: 129-137). The principle of all CECOG consensus is such that evidence-based recommendations for state-of-the-art treatment are given upon which all participants and authors of the manuscript have to agree (Beslija S, Bonneterre J, Burstein HJ et al. Third consensus on medical treatment of metastatic breast cancer. Ann Oncol 2009; 20 (11): 1771-1785). This is of particular importance in diseases in which treatment options depend on very particular clinical and biologic variables (Zielinski CC, Beinert T, Crawford J et al. Consensus on medical treatment of non-small-cell lung cancer—update 2004. Lung Cancer 2005; 50: 129-137; Beslija S, Bonneterre J, Burstein HJ et al. Third consensus on medical treatment of metastatic breast cancer. Ann Oncol 2009; 20 (11): 1771-1785). Since the publication of the last CECOG consensus on the medical treatment of NSCLC, a series of diagnostic tools for the characterization of biomarkers for personalized therapy for NSCLC as well as therapeutic options including adjuvant treatment, targeted therapy, and maintenance treatment have emerged and strongly influenced the field. Thus, the present third consensus was generated that not only readdresses previous disease-related issues but also expands toward recent developments in the management of NSCLC. It is the aim of the present consensus to summarize minimal quality-oriented requirements for individual patients with NSCLC in its various stages based upon levels of evidence in the light of a rapidly expanding array of individual therapeutic options

Published
2017

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