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2. Atrial fibrillation burden, symptoms and medication use after left bundle branch area pacing combined with AV-node ablation in patients with symptomatic atrial fibrillation

Author

Rijks, J, primary, Lankveld, T, additional, Manusama, R, additional, Broers, B, additional, Van Stipdonk, A M W, additional, Chaldoupi, S M, additional, Ter Belle, R M A, additional, Schotten, U, additional, Linz, D, additional, Luermans, J G L M, additional, and Vernooy, K, additional

Published
2024
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3. Drogues : mineur-e-s et réduction des risques ? [Drugs: minors and harm reduction?]

Author

Armengaud, J.B., Baud, C.A., Broers, B., Guillod, L., Hasselgard-Rowe, J., Junod, V., Perrin, D., and Simon, O.

Subjects
Humans, Minors, Harm Reduction, Public Health, Psychotropic Drugs/adverse effects, Substance-Related Disorders/epidemiology, Substance-Related Disorders/prevention & control
Abstract

The use of controlled substances (narcotics and psychotropic substances) poses increased risks for minors. However, minors are generally excluded from existing harm reduction services (e.g. drug consumption rooms, drug checking, exchange of consumption material). Based on public health considerations, the authors recommend the establishment of harm reduction services for minors.

Published
2023

4. Suicide assisté : un besoin de clarification [Assisted suicide: a need for clarification]

Author

Baud, C.A., Broers, B., Junod, V., Michaud, L., Pautex, S., and Simon, O.

Subjects
Humans, Suicide, Assisted, Euthanasia, Switzerland, Attitude of Health Personnel
Abstract

In Switzerland, altruistic assisted suicide is permitted. We present here the federal regulations, the deontological rules, the provisions adopted by the cantons and other requirements applicable to assisted suicide. Given the complexity of these different rules and the legal questions that remain open, we recommend the preparation of brochures for patients, as well as better training and support for people faced with requests for assisted suicide.

Published
2023

6. Addictions : ce qui a changé en 2022 [Addiction: what's new in 2022]

Author

Novet, B., Simon, O., Bonjour, S., Andronicos, M., Khazaal, Y., Thorens, G., Broers, B., Favrod-Coune, T., Gothuey, I., Bouzegaou, R., Bertholet, N., and Daeppen, J.B.

Subjects
Humans, Behavior, Addictive/therapy
Abstract

Addictions appear everywhere, mutate, transform with new products and behaviors, playing on our painstaking efforts to try to control them. Drawn into this current, the impression that dominates invites more to understand and to coax rather than to fight. Addictions are our condition, let's deal with it, rather than fight against them. It is therefore a question of knowing the products, that everyone can identify their level of risk, and of giving as many tools as possible, at any age, whatever the behavior or the product. This article shows us that there is a lot to do, from school benches to liver transplantation. There is also a lot to discover, in the recognition of the therapeutic virtues, of cannabinoids for example or even in their prescription, of pharmaceutical heroin for example, sometimes by far the best option.

Published
2023

7. A Global Survey on Changes in the Supply, Price, and Use of Illicit Drugs and Alcohol, and Related Complications During the 2020 COVID-19 Pandemic

Author

Farhoudian, A, Radfar, S, Ardabili, H, Rafei, P, Ebrahimi, M, Zonoozi, A, De Jong, C, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Hansen, H, Brady, K, Potenza, M, Baldacchino, A, Ekhtiari, H, Abagiu, A, Abouna, F, Ahmed, M, Al-Ansari, B, Al-Khair, F, Almaqbali, M, Ambekar, A, Arya, S, Asebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Busse, A, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Deilamizade, A, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Isra, T, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Kurniasanti, K, Lev, R, Lee, H, Lengvenyte, A, Lev-Ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Massah, O, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon, T, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Quiros, R, Qurishi, R, Rafiq, N, Raghavendra Rao, R, Ratta-Apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Wee Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Farhoudian A., Radfar S. R., Ardabili H. M., Rafei P., Ebrahimi M., Zonoozi A. K., De Jong C. A. J., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Hansen H., Brady K. T., Potenza M. N., Baldacchino A. M., Ekhtiari H., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-Ansari B., Al-Khair F. M. A., Almaqbali M. H., Ambekar A., Arya S., Asebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Busse A., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., Cherpitel J. J. E. N., Clark K. J., Cyders M. A., de Bernardis E., Deilamizade A., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H. F. -H., Indradewi R. N., Iskandar S., Isra T. N., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S. -G. S., Kimball A. M., Kljucevic Z., Kurniasanti K. S., Lev R., Lee H. K., Lengvenyte A., Lev-Ran S., Mabelya G. S., Mahi M. A. E., Maphisa J. M., Maremmani I., Masferrer L., Massah O., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T. N. J., Narasimha V. L., Ndionuka N., Nejatisafa A. -A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Quiros R. A., Qurishi R., Rafiq N. U. Z., Raghavendra Rao R., Ratta-Apha W., Raymond K. -L., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Wee Teck J. B. T., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., Farhoudian, A, Radfar, S, Ardabili, H, Rafei, P, Ebrahimi, M, Zonoozi, A, De Jong, C, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Hansen, H, Brady, K, Potenza, M, Baldacchino, A, Ekhtiari, H, Abagiu, A, Abouna, F, Ahmed, M, Al-Ansari, B, Al-Khair, F, Almaqbali, M, Ambekar, A, Arya, S, Asebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Busse, A, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Deilamizade, A, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Isra, T, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Kurniasanti, K, Lev, R, Lee, H, Lengvenyte, A, Lev-Ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Massah, O, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon, T, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Quiros, R, Qurishi, R, Rafiq, N, Raghavendra Rao, R, Ratta-Apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Wee Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Farhoudian A., Radfar S. R., Ardabili H. M., Rafei P., Ebrahimi M., Zonoozi A. K., De Jong C. A. J., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Hansen H., Brady K. T., Potenza M. N., Baldacchino A. M., Ekhtiari H., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-Ansari B., Al-Khair F. M. A., Almaqbali M. H., Ambekar A., Arya S., Asebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Busse A., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., Cherpitel J. J. E. N., Clark K. J., Cyders M. A., de Bernardis E., Deilamizade A., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H. F. -H., Indradewi R. N., Iskandar S., Isra T. N., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S. -G. S., Kimball A. M., Kljucevic Z., Kurniasanti K. S., Lev R., Lee H. K., Lengvenyte A., Lev-Ran S., Mabelya G. S., Mahi M. A. E., Maphisa J. M., Maremmani I., Masferrer L., Massah O., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T. N. J., Narasimha V. L., Ndionuka N., Nejatisafa A. -A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Quiros R. A., Qurishi R., Rafiq N. U. Z., Raghavendra Rao R., Ratta-Apha W., Raymond K. -L., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Wee Teck J. B. T., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., and Zhao M.

Abstract

Background and Aims: COVID-19 has infected more than 77 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing, and “lockdown” measures have affected drug and alcohol supply chains and subsequently their availability, price, and use patterns, with possible downstream effects on presentations of SUDs and demand for treatment. Given the lack of multicentric epidemiologic studies, we conducted a rapid global survey within the International Society of Addiction Medicine (ISAM) network in order to understand the status of substance-use patterns during the current pandemic. Design: Cross-sectional survey. Setting: Worldwide. Participants: Starting on April 4, 2020 during a 5-week period, the survey received 185 responses from 77 countries. Measurements: To assess addiction medicine professionals' perceived changes in drug and alcohol supply, price, use pattern, and related complications during the COVID-19 pandemic. Findings: Participants reported (among who answered “decreased” or “increased”) a decrease in drug supply (69.0%) and at the same time an increase in price (95.3%) globally. With respect to changes in use patterns, an increase in alcohol (71.7%), cannabis (63.0%), prescription opioids (70.9%), and sedative/hypnotics (84.6%) use was reported, while the use of amphetamines (59.7%), cocaine (67.5%), and opiates (58.2%) was reported to decrease overall. Conclusions: The global report on changes in the availability, use patterns, and complications of alcohol and drugs during the COVID-19 pandemic should be considered in making new policies and in developing mitigating measures and guidelines during the current pandemic (and probable future ones) in order to minimize risks to people with SUD.

Published
2021

8. Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey

Author

Radfar, S, De Jong, C, Farhoudian, A, Ebrahimi, M, Rafei, P, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Massah, O, Deylamizadeh, A, Brady, K, Busse, A, Potenza, M, Ekhtiari, H, Baldacchino, A, Abagiu, A, Abouna, F, Ahmed, M, Al-ansari, B, Mahmmoud Abu Al-khair, F, Almaqbali, M, Ambekar, A, Ardabili, H, Arya, S, Lasebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, de Jesus Eduardo Noyola Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Siste, K, Lev, R, Lee, H, Lengvenyte, A, Lev-ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon T N, J, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Alberto Quiros, R, Qurishi, R, Rafiq, N, Rao, R, Ratta-apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Zonoozi, A, Radfar S. R., De Jong C. A. J., Farhoudian A., Ebrahimi M., Rafei P., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Massah O., Deylamizadeh A., Brady K. T., Busse A., Potenza M. N., Ekhtiari H., Baldacchino A. M., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-ansari B., Mahmmoud Abu Al-khair F., Almaqbali M. H., Ambekar A., Ardabili H. M., Arya S., Lasebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., de Jesus Eduardo Noyola Cherpitel J., Clark K. J., Cyders M. A., de Bernardis E., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H., Indradewi R. N., Iskandar S., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S., Kimball A. M., Kljucevic Z., Siste K., Lev R., Lee H. K., Lengvenyte A., Lev-ran S., Mabelya G. S., Mahi M. A. E., Maphisa J., Maremmani I., Masferrer L., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T N J., Narasimha V. L., Ndionuka N., Nejatisafa A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Alberto Quiros R., Qurishi R., Rafiq N. U. Z., Rao R. R., Ratta-apha W., Raymond K., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Teck J., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., Zonoozi A. K., Radfar, S, De Jong, C, Farhoudian, A, Ebrahimi, M, Rafei, P, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Massah, O, Deylamizadeh, A, Brady, K, Busse, A, Potenza, M, Ekhtiari, H, Baldacchino, A, Abagiu, A, Abouna, F, Ahmed, M, Al-ansari, B, Mahmmoud Abu Al-khair, F, Almaqbali, M, Ambekar, A, Ardabili, H, Arya, S, Lasebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, de Jesus Eduardo Noyola Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Siste, K, Lev, R, Lee, H, Lengvenyte, A, Lev-ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon T N, J, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Alberto Quiros, R, Qurishi, R, Rafiq, N, Rao, R, Ratta-apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Zonoozi, A, Radfar S. R., De Jong C. A. J., Farhoudian A., Ebrahimi M., Rafei P., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Massah O., Deylamizadeh A., Brady K. T., Busse A., Potenza M. N., Ekhtiari H., Baldacchino A. M., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-ansari B., Mahmmoud Abu Al-khair F., Almaqbali M. H., Ambekar A., Ardabili H. M., Arya S., Lasebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., de Jesus Eduardo Noyola Cherpitel J., Clark K. J., Cyders M. A., de Bernardis E., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H., Indradewi R. N., Iskandar S., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S., Kimball A. M., Kljucevic Z., Siste K., Lev R., Lee H. K., Lengvenyte A., Lev-ran S., Mabelya G. S., Mahi M. A. E., Maphisa J., Maremmani I., Masferrer L., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T N J., Narasimha V. L., Ndionuka N., Nejatisafa A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Alberto Quiros R., Qurishi R., Rafiq N. U. Z., Rao R. R., Ratta-apha W., Raymond K., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Teck J., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., and Zonoozi A. K.

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health responses in their own 77 countries in terms of SUD treatment and harm reduction services. The health responses were categorized around (1) managerial measures and systems, (2) logistics, (3) service providers, and (4) vulnerable groups. Results: Respondents from over 88% of countries reported that core medical and psychiatric care for SUDs had continued; however, only 56% of countries reported having had any business continuity plan, and 37.5% of countries reported shortages of methadone or buprenorphine supplies. Participants of 41% of countries reported partial discontinuation of harm-reduction services such as needle and syringe programs and condom distribution. Fifty-seven percent of overdose prevention interventions and 81% of outreach services were also negatively impacted. Conclusions: Participants reported that SUD treatment and harm-reduction services had been significantly impacted globally early during the COVID-19 pandemic. Based on our findings, we highlight several issues and complications resulting from the pandemic concerning people with SUDs that should be tackled more efficiently during the future waves or similar pandemics. The issues and potential strategies comprise the following: (1) helping policymakers to generate business continuity plans, (2) maintaining the use of evidence-based interventions for people with SUDs, (3) being prepared for adequate medication supplies, (4) integrating harm reduction programs with other treatment modalities, and (5) having specific considerations for vulnerable groups such as immigrants and refugees.

Published
2021

9. Selfcare des médecins ou les cordonniers de Montaigne [Physician selfcare or the cobblers of Montaigne]

Author

Cohidon, C., Mahler, L., Broers, B., Favrod-Coune, T., Amir Moussa, M., and Sebo, P.

Subjects
Humans, Physicians, Referral and Consultation, Self Care, Surveys and Questionnaires, Switzerland
Abstract

A recent survey conducted in the French-speaking part of Switzerland ("Romandie") showed that only about half of the primary care physicians (PCP) in Romandie had a personal doctor. Moreover, 37 % of the PCP declared they had foregone consulting a doctor for a health problem or a check-up during the past year. Finally, 29 % of them had chosen to continue working despite being ill. The literature describes multiple origins for these behaviors, both systemic (especially workload) and individual (denial, fear of social and peer judgment, culture of invincibility…). There is room for improvement for this still too often overlooked problem, in order to enhance the PCP's health (or well-being), and consequently the quality of care.

Published
2022

13. Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey

Author

Radfar, SR, De Jong, CAJ, Farhoudian, A, Ebrahimi, M, Rafei, P, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Massah, O, Deylamizadeh, A, Brady, KT, Busse, A, Potenza, MN, Ekhtiari, H, Baldacchino, AM, Abagiu, AO, Abouna, FDN, Ahmed, MH, Al-ansari, B, Abu Al-khair, F Mahmmoud, Almaqbali, MH, Ambekar, A, Ardabili, HM, Arya, S, Lasebikan, VO, Ayasreh, MA, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Butner, JL, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, de Jesús Eduardo Noyola Cherpitel, J, Clark, KJ, Cyders, MA, de Bernardis, E, Derry, JE, Dhagudu, NK, Dolezalova, P, Dom, G, Dunlop, AJ, Elhabiby, MM, Elkholy, H, Essien, NF, Farah, GI, Ferri, M, Floros, GD, Friedman, C, Fuderanan, CH, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, IA, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, PS, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, IIM, Ieong, HFH, Indradewi, RN, Iskandar, S, Jain, S, James, Sandi, Javadi, SMH, Joe, KH, Jokubonis, D, Jovanova, AT, Kamal, RM, Kantchelov, AI, Kathiresan, P, Katzman, G, Kawale, P, Kern, AM, Kessler, FHP, Kim, SGS, Kimball, AM, Kljucevic, Z, Siste, K, Lev, R, Lee, HK, Lengvenyte, A, Lev-ran, S, Mabelya, GS, Mahi, MAE, Maphisa, JM, Maremmani, I, Masferrer, L, McCambridge, O, and McGovern, GG

Subjects
Uncategorized
Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health responses in their own 77 countries in terms of SUD treatment and harm reduction services. The health responses were categorized around (1) managerial measures and systems, (2) logistics, (3) service providers, and (4) vulnerable groups. Results: Respondents from over 88% of countries reported that core medical and psychiatric care for SUDs had continued; however, only 56% of countries reported having had any business continuity plan, and 37.5% of countries reported shortages of methadone or buprenorphine supplies. Participants of 41% of countries reported partial discontinuation of harm-reduction services such as needle and syringe programs and condom distribution. Fifty-seven percent of overdose prevention interventions and 81% of outreach services were also negatively impacted. Conclusions: Participants reported that SUD treatment and harm-reduction services had been significantly impacted globally early during the COVID-19 pandemic. Based on our findings, we highlight several issues and complications resulting from the pandemic concerning people with SUDs that should be tackled more efficiently during the future waves or similar pandemics. The issues and potential strategies comprise the following: (1) helping policymakers to generate business continuity plans, (2) maintaining the use of evidence-based interventions for people with SUDs, (3) being prepared for adequate medication supplies, (4) integrating harm reduction programs with other treatment modalities, and (5) having specific considerations for vulnerable groups such as immigrants and refugees.

Published
2021
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14. An international consultation on case reports in addiction medicine

Author

Qurishi, R., Drenth, J.P.H., Baldacchino, A.M., Broers, B., Buwalda, V.J.A., Jong, C.A.J. de, Qurishi, R., Drenth, J.P.H., Baldacchino, A.M., Broers, B., Buwalda, V.J.A., and Jong, C.A.J. de

Abstract

Item does not contain fulltext, Background: A Case Report (CR) is a scientific documentation of a single clinical observation which serves to inform but also to educate the reader. Case reports help to compliment clinical critical thinking in Addiction Medicine (AM) when there is limited evidence base. Aim: This study aims to analyze how international clinical and research leaders in Addiction Medicine view Case Reports and their relevance to bridge the gap between evidence and practice. Methods: A semi-structured, audio-recorded interviews were conducted with 12 international Addiction Medicine scholars. Thematic content analysis was used to code the transcribed interview data. Results: Interviewees showed a positive view toward publishing Case Reports in Addiction Medicine. They found that medical students and clinicians working in the field of Addiction Medicine should be encouraged to share and record cases of clinical interaction. To aid this process (1) formal supervised training in case reporting within an academic environment must be facilitated. And (2) journals should also offer a place to publish Case Reports. Conclusion: The international scholars agree that Case Reports are important for the development of Addiction Medicine and that they can contribute to a better understanding of patients with substance use disorder.

Published
2021

18. Addictions [Addictions]

Author

Vogel, M., Strasser, H., Thorens, G., Zullino, D., Humair, J.P., Simon, O., Broers, B., Haettel, C., Devaud, C., Gothuey, I., Favrod-Counej, T., and Daeppen, J.B.

Subjects
Analgesics, Opioid, Behavior, Addictive, Humans, Opioid-Related Disorders, Pain Management
Abstract

This article describes a new form of administration of inhaled prescribed heroin currently under investigation. It underlines the particularity of opioid agonist prescription in jail and presents new perspectives in using psilocybin in addiction medicine treatment. A brief literature review about vaping confirms its interest in quitting cigarette, with a cost of addiction to vaping and recent worrisome reports of chemical pneumonia. Finally, the withdrawal of WHO guidelines on opiates use in pain management, in the context of a suspicion of conflict of interest, underlines the sensible balance between over- and under- prescription of opiates in analgesic treatment.

Published
2020

27. Climbing a Ladder System by Frequency-Chirped Laser Pulses

Author

Noordam, L. D., primary, Balling, P., additional, Broers, B., additional, Hoogenraad, J. H., additional, Maas, D. J., additional, van Amersfoort, P. W., additional, van Linden van den Heuvell, H. B., additional, van der Meer, A. F. G., additional, and Vrijen, R. B., additional

Published
1994
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30. Substance misuse education for physicians: Why older people are important

Author

Ca, Jong, Goodair C, Crome I, Jokubonis D, El-Guebaly N, Geert Dom, Schellekens A, Broers B, Subata E, Gk, Welle-Strand, Luycks L, Wolters M, and Schoof T

Subjects
Other Research Radboud Institute for Health Sciences [Radboudumc 0], Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], United Kingdom, United States, Experimental Psychopathology and Treatment, substance-related disorders, Behavior, Addictive, addiction psychiatry, Humans, medical education, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Addiction Medicine, Perspectives, Education, Medical, Undergraduate, Netherlands
Abstract

This perspective article focuses on the need for training and education for undergraduate medical students on substance-related disorders, and describes initiatives undertaken in the United Kingdom (UK), Netherlands, United States (US), and Norway to develop the skills, knowledge, and attitudes needed by future doctors to treat patients adequately. In addition, we stress that in postgraduate training, further steps should be taken to develop Addiction Medicine as a specialized and transverse medical domain. Alcohol use disorder is a growing public health problem in the geriatric population, and one that is likely to continue to increase as the baby boomer generation ages. Prescription drug misuse is a major concern, and nicotine misuse remains problematic in a substantial minority. Thus, Addiction Medicine training should address the problems for this specific population. In recent years, several countries have started an Addiction Medicine specialty. Although addiction psychiatry has been a subspecialty in the UK and US for more than 20 years, in most countries it has been a more recent development. Additional courses on addiction should be integrated into the curriculum at both undergraduate and postgraduate levels, as well as form part of the continuous training of other medical specialists. It is recommended that further research and mapping of what is currently taught in medical programs be undertaken, so as to enhance medical education in addiction and improve treatment services.

Published
2016

32. Role of rotational alignment in molecule–surface interaction for CH3F and OCS.

Author

Broers, B., van der Meer, G. J., Hoogeveen, R. W. M., and Hermans, L. J. F.

Subjects
*CARBON compounds, *HYDROGEN, *FLUORINE compounds, *GLASS
Abstract

The influence of rotational alignment on molecule–surface interaction is studied for CH3F and OCS colliding with a glass surface. Experiments were performed at 285 K with the technique of surface light-induced drift using a flat channel, the alignment being produced through excitation by linearly polarized light. For molecules having rotational energy well below thermal, it is found that the accommodation coefficient for parallel momentum α, which can be related to the trapping/desorption probability, is larger if the angular momentum J is parallel to the surface (‘‘cartwheeling motion’’) than if perpendicular (‘‘helicopters’’). For CH3F the experiments indicate that this difference decreases strongly with increasing K, denoting the component of J along the principal molecular axis. Experiments on OCS confirm this behavior. For molecules having rotational energy well above thermal, however, the reverse behavior is found, viz., α is larger for helicopters than for cartwheels. This is consistent with molecular beam data on the system NO/Pt(111) studied by Jacobs et al. [J. Chem. Phys. 91, 3182 (1989)]. A possible explanation of the observations is given in terms of the role of rotational (de-)excitation in the accommodation process. [ABSTRACT FROM AUTHOR]

Published
1991
Full Text
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33. Protocol for a systematic review of the factors associated with binge drinking among adolescents and young adults

Author

Hasselgard-Rowe, J, Broers, B, Haller, DM, Hasselgard-Rowe, J, Broers, B, and Haller, DM

Abstract

BACKGROUND: Alcohol use is the behaviour that has the most significant impact on the mortality and morbidity of young people, and binge drinking is becoming the norm among this population. The burden of disease of binge drinking during adolescence and young adulthood is significant and warrants the development of effective prevention strategies. Although the literature on risk factors for excessive substance use has been increasing, to our knowledge, a systematic review of the factors associated with binge drinking among young people has not yet been conducted. This study aims to identify and organise the factors associated with binge drinking among young people aged 15 to 24 years; and to provide a framework to further understand these factors in order to better target prevention strategies. METHODS/DESIGN: This systematic review of the literature will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. The databases PubMed, Embase, PsycINFO and Social Care will be searched for articles published between 1 January 2006 and 31 December 2015. Our search focuses on studies examining the risk factors for binge drinking among young people (between the ages of 15 and 24). Observational studies (cross-sectional, cohort and case-control studies) will be included, while randomised controlled trials will be excluded. Case series and case reports will also be excluded, while reviews, if relevant, will be included. The primary outcome is binge drinking. Secondary outcomes include indicators of frequency and consequences of binge drinking. Two reviewers will independently screen articles, extract relevant data and assess the quality of the studies. DISCUSSION: This systematic review will add to our knowledge and understanding of binge drinking among young people. It will allow us to identify the main risk and protective factors associated with binge drinking among this population and ultimately help to define the lines for fur

Published
2017

34. Substance misuse education for physicians: Why older people are important

Author

Jong, C.A.J. de, Goodair, C., Crome, I., Jokubonis, D., el-Guebaly, N., Dom, G., Schellekens, A.F.A., Broers, B., Subata, E., Welle-Strand, G.K., Luycks, L., Wolters, M., Schoof, T., Jong, C.A.J. de, Goodair, C., Crome, I., Jokubonis, D., el-Guebaly, N., Dom, G., Schellekens, A.F.A., Broers, B., Subata, E., Welle-Strand, G.K., Luycks, L., Wolters, M., and Schoof, T.

Abstract

Contains fulltext : 157391.pdf (publisher's version ) (Open Access)

Published
2016

35. A new neuropsychological instrument measuring effects of age and drugs on fitness to drive: development, reliability, and validity of MedDrive

Author

Vaucher, P., Pétremand, E., Cardoso, I., Veldstra, J., Broers, B., Bindschaedler, C., Annoni, J.M., Mangin, P., and Favrat, B.

Abstract

Background: Current guidelines underline the limitations of existing instruments to assess fitness to drive and the poor adaptability of batteries of neuropsychological tests in primary care settings. Aims: To provide a free, reliable, transparent computer based instrument capable of detecting effects of age or drugs on visual processing and cognitive functions. Methods: Relying on systematic reviews of neuropsychological tests and driving performances, we conceived four new computed tasks measuring: visual processing (Task1), movement attention shift (Task2), executive response, alerting and orientation gain (Task3), and spatial memory (Task4). We then planned five studies to test MedDrive's reliability and validity. Study-1 defined instructions and learning functions collecting data from 105 senior drivers attending an automobile club course. Study-2 assessed concurrent validity for detecting minor cognitive impairment (MCI) against useful field of view (UFOV) on 120 new senior drivers. Study-3 collected data from 200 healthy drivers aged 20-90 to model age related normal cognitive decline. Study-4 measured MedDrive's reliability having 21 healthy volunteers repeat tests five times. Study-5 tested MedDrive's responsiveness to alcohol in a randomised, double-blinded, placebo, crossover, dose-response validation trial including 20 young healthy volunteers. Results: Instructions were well understood and accepted by all senior drivers. Measures of visual processing (Task1) showed better performances than the UFOV in detecting MCI (ROC 0.770 vs. 0.620; p=0.048). MedDrive was capable of explaining 43.4% of changes occurring with natural cognitive decline. In young healthy drivers, learning effects became negligible from the third session onwards for all tasks except for dual tasking (ICC=0.769). All measures except alerting and orientation gain were affected by blood alcohol concentrations. Finally, MedDrive was able to explain 29.3% of potential causes of swerving on the driving simulator. Discussion and conclusions: MedDrive reveals improved performances compared to existing computed neuropsychological tasks. It shows promising results both for clinical and research purposes.

Published
2013

37. Reasons for encounter in young people consulting a family doctor in the French speaking part of Switzerland: a cross sectional study

Author

Meynard, A, Broers, B, Lefebvre, D, Narring, F, Haller, DM, Meynard, A, Broers, B, Lefebvre, D, Narring, F, and Haller, DM

Abstract

BACKGROUND: Knowledge of patient's reasons for encounter is useful to inform health service planning and health professional education. Our aim was to describe reasons for encounter as stated by an unselected group of young people attending primary care practices in the French-speaking part of Switzerland. METHODS: Consecutive patients aged between 15 and 24 years were recruited as part of the PRISM-Ado trial (n = 594). They completed an anonymous questionnaire in the waiting room, including their main reason for encounter (free text). Reasons for encounter were coded using ICPC-2 classification and analyzed according to sex, age and living in a rural or urban area. RESULTS: 95 % of questionnaires contained valid data about reasons for encounter (n = 567). General and unspecific (A) reasons were the most common in boys (44 %) and girls (42 %), followed by respiratory, musculoskeletal, dermatological and psychological reasons. Psychological reasons were more frequent in girls attending urban practices; musculoskeletal and dermatological reasons were more frequent in rural areas. Sexually transmitted infections or substance use were very rarely stated as a reason for encounter. CONCLUSIONS: This is the first study describing reasons for encounter as stated by young people themselves in primary care in Switzerland. These findings provide useful guidance for family doctors training and health service planning in Europe. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry, ACTRN12608000432314 .

Published
2015

38. AOW en Anw

Author

Weerepas, M.J.G.A.M., Bollen-Vandenboorn, A.H.H., Broers, B., Bijnen, H. van, Tax Law, and RS: FdR IC Fiscale vraagstukken

Published
2010

40. Text-messaging versus telephone reminders to reduce missed appointments in an academic primary care clinic: a randomized controlled trial

Author

Perron, NJ, Dao, MD, Righini, NC, Humair, J-P, Broers, B, Narring, F, Haller, DM, Gaspoz, J-M, Perron, NJ, Dao, MD, Righini, NC, Humair, J-P, Broers, B, Narring, F, Haller, DM, and Gaspoz, J-M

Abstract

BACKGROUND: Telephone or text-message reminders have been shown to significantly reduce the rate of missed appointments in different medical settings. Since text-messaging is less resource-demanding, we tested the hypothesis that text-message reminders would be as effective as telephone reminders in an academic primary care clinic. METHODS: A randomized controlled non-inferiority trial was conducted in the academic primary care division of the Geneva University Hospitals between November 2010 and April 2011. Patients registered for an appointment at the clinic, and for whom a cell phone number was available, were randomly selected to receive a text-message or a telephone call reminder 24 hours before the planned appointment. Patients were included each time they had an appointment. The main outcome was the rate of unexplained missed appointments. Appointments were not missed if they were cancelled or re-scheduled before or independently from the intervention. We defined non-inferiority as a difference below 2% in the rate of missed appointments and powered the study accordingly. A satisfaction survey was conducted among a random sample of 900 patients (response rate 41%). RESULTS: 6450 patients were included, 3285 in the text-message group and 3165 in the telephone group. The rate of missed appointments was similar in the text-message group (11.7%, 95% CI: 10.6-12.8) and in the telephone group (10.2%, 95% CI: 9.2-11.3 p = 0.07). However, only text message reminders were cost-effective. No patient reported any disturbance by any type of reminder in the satisfaction survey. Three quarters of surveyed patients recommended its regular implementation in the clinic. CONCLUSIONS: Text-message reminders are equivalent to telephone reminders in reducing the proportion of missed appointments in an academic primary care clinic and are more cost-effective. Both types of reminders are well accepted by patients.

Published
2013

41. Systemic sclerosis and its pulmonary complications in The Netherlands: an epidemiological study.

Author

Vonk, M.C., Broers, B., Heijdra, Y.F., Ton, E., Snijder, R., Dijk, A.P.J. van, Laar, J.M. van, Bootsma, H.J., Hal, P.T. van, Hoogen, F.H.J. van den, Daele, P.L. van, Vonk, M.C., Broers, B., Heijdra, Y.F., Ton, E., Snijder, R., Dijk, A.P.J. van, Laar, J.M. van, Bootsma, H.J., Hal, P.T. van, Hoogen, F.H.J. van den, and Daele, P.L. van

Abstract

Contains fulltext : 81439.pdf (publisher's version ) (Closed access), The prevalence and incidence of systemic sclerosis (SSc) in The Netherlands is unknown. The same holds true for its leading causes of death: pulmonary fibrosis and pulmonary arterial hypertension (PAH), for which effective treatment options have recently become available. OBJECTIVE: To establish the prevalence and incidence of SSc and its pulmonary complications. METHODS: Detailed information on patients in the POEMAS registry, "Pulmonary Hypertension Screening, a Multidisciplinary Approach in Scleroderma", consisting of 819 patients, was combined with a nationwide questionnaire. RESULTS: By combining the two sources the prevalence of SSc was found to be 8.9 per 100 000 adults. The incidence was 0.77 patients per 100 000 per year. PAH was diagnosed in 9.9% of SSc patients. The prevalence of interstitial lung disease in SSc varied from 19% to 47% depending on the definition used. CONCLUSION: This study clarifies the epidemiology of SSc in The Netherlands and confirms the frequent occurrence of pulmonary complications, based on 654 cases. This can and will be studied further in the ongoing POEMAS study.

Published
2009

42. Swiss multicenter study evaluating the efficacy, feasibility and safety of peginterferon-alfa-2a and ribavirin in patients with chronic hepatitis C in official opiate substitution programs

Author

Fried, R, Monnat, M, Seidenberg, A, Oppliger, R, Schmid, P, Herold, M, Isler, M, Broers, B, Kölliker, C, Schönbucher, P, Frei, M, Huber, M, Fried, R, Monnat, M, Seidenberg, A, Oppliger, R, Schmid, P, Herold, M, Isler, M, Broers, B, Kölliker, C, Schönbucher, P, Frei, M, and Huber, M

Abstract

BACKGROUND: Though patients in opiate substitution programs are commonly infected with HCV, due to safety and efficacy concerns, they are rarely treated with interferon and ribavirin. METHODS: In a multicenter study, HCV-infected patients in opiate maintenance treatment programs received 180 microg pegylated interferon-alfa-2a once weekly, plus daily ribavirin for 24 weeks (genotypes 2, 3), or 48 weeks (genotypes 1, 4). RESULTS: Of the 67 patients enrolled, 31 (46%) had HCV genotypes 1 or 4, and 36 (54%) had genotypes 2 or 3. Intent-to-treat analysis showed end-of-treatment virologic response in 75% of patients (81% of genotypes 2 or 3; 65% of genotypes 1 or 4), and a sustained virologic response in 61% of patients (72% of genotypes 2 or 3; 48% of genotypes 1 or 4). Fifteen patients (22%) did not complete the study, in 5 (8%) cases because of severe adverse events. CONCLUSIONS: Drug users with chronic HCV infection, regularly attending an opiate maintenance program in which close collaboration between hepatologists/internists and addiction specialists is assured, can be treated effectively and safely with pegylated interferon-alfa-2a and ribavirin. Treatment results are very similar to those in other patient groups, and thus therapy should also be considered for this population.

Published
2008

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