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Your search keyword '"Brook, C. S."' showing total 16 results
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16 results on '"Brook, C. S."'

1. Die neue Parkinson-Schmerzklassifikation (PSK)

Author

Mylius, V., Perez Lloret, S., Brook, C. S., Krüger, M. T., Hägele-Link, S., Gonzenbach, R., Kassubek, J., Bohlhalter, S., Lefaucheur, J. P., Timmermann, L., Kägi, G., Brugger, F., Ciampi de Andrade, D., and Möller, J. C.

Published
2022
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11. Solid-Phase Synthesis of a Combinatorial Array of 1,3-Bis(acylamino)-2-butanones, Inhibitors of the Cysteine Proteases Cathepsins K and L

Author

Yamashita, D. S., Dong, X., Oh, H.-J., Brook, C. S., Tomaszek, T. A., Szewczuk, L., Tew, D. G., and Veber, D. F.

Abstract

To more rapidly prepare members of the 1,3-bis(acylamino)-2-butanone class of cysteine protease inhibitors, a solid-phase synthesis was developed. 1-Azido-3-amino-2,2-dimethoxybutane (4), which has the two amino groups differentiated and the ketone protected as a a ketal, served as a surrogate for the 1,3-diamino-2-butanone core. Amine (4) was coupled to the BAL-resin-linked carboxylic acids derived from α-amino acid esters. Evaluation of a small combinatorial array by measuring inhibition constants (Ki,apps) against cathepsins K, L, and B provided some structure−activity relationship trends with respect to selectivity and potency. Novel, potent inhibitors of cathepsins K and L were identified.

Published
1999

12. Syntheses of Strychnos and Aspidospermatan Type Alkaloids. 4. Formation of the Pentacyclic Core by an Intramolecular Diels Alder Reaction

Author

Kuehne, M. E., Brook, C. S., and Frasier, D. A.

Abstract

Reactions of hetero-substituted acetaldehydes, or ethynyl methyl ketone, or methyl propiolate with methyl 1,2,3,4,5,8-hexahydroazonino[6,7-b]indole-7-carboxylate gave the pentacyclic core of the strychnos alkaloids with substituents on the central bridge.

Published
1994
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16. [The new Parkinson's disease pain classification system (PD-PCS)].

Author

Mylius V, Perez Lloret S, Brook CS, Krüger MT, Hägele-Link S, Gonzenbach R, Kassubek J, Bohlhalter S, Lefaucheur JP, Timmermann L, Kägi G, Brugger F, Ciampi de Andrade D, and Möller JC

Subjects
Humans, Pain Measurement, Reproducibility of Results, Surveys and Questionnaires, Neuralgia complications, Neuralgia diagnosis, Neuralgia therapy, Parkinson Disease complications, Parkinson Disease diagnosis
Abstract

Background: Chronic pain is a common non-motor symptom in patients with Parkinson's disease (PD)., Aim: To facilitate the diagnosis of pain in PD, we developed a new classification system the Parkinson's disease pain classification system (PD-PCS) and translated the corresponding validated questionnaire into German., Methods: A causal relationship of the respective pain syndrome with PD can be determined by four questions before assigning it hierarchically into one of three pain categories (neuropathic, nociceptive and nociplastic)., Results: In the initial validation study 77% of the patients (122/159) had PD-associated pain comprising 87 (55%) with nociceptive, 36 (22%) with nociplastic and 24 (16%) with neuropathic pain. The study revealed a high validity of the questionnaire and a moderate intrarater and interrater reliability. The questionnaire has been adapted into German and employed in 30 patients., Discussion: The PD-PCS questionnaire is a valid and reliable tool to determine the relationship of a pain syndrome with PD before classifying it according to the underlying category, facilitating further diagnostics and treatment., (© 2022. The Author(s).)

Published
2022
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