493 results on '"Brosh, Robert"'
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2. Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease
3. Biochemical analysis of SARS-CoV-2 Nsp13 helicase implicated in COVID-19 and factors that regulate its catalytic functions
4. Replication stress as a driver of cellular senescence and aging
5. DNA fiber analyses to study functional importance of helicases and associated factors during replication stress
6. Synthetic Lethal Interactions of RECQ Helicases
7. Editorial: DNA repair and interventions in aging
8. Phosphorylation-Dependent Association of WRN with RPA is Required for Recovery of Replication Forks Stalled at Secondary DNA Structures
9. Frontiers in aging special issue: DNA repair and interventions in aging perspective on “loss of epigenetic information as a cause of mammalian aging”
10. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
11. DNA Replication Stress
12. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
13. Impact papers on aging in 2009.
14. Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
15. Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism
16. Single-Molecule DNA Fiber Analyses to Characterize Replication Fork Dynamics in Living Cells
17. Cellular Assays to Study the Functional Importance of Human DNA Repair Helicases
18. Data from Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway
19. Abstract 2676: SARS-CoV-2 Nsp13 Catalytic Efficiency is Regulated by ATP: Mg2+ Stoichiometry and Functional Cooperativity Among Nsp13 Molecules
20. Abstract 2680: RECON Syndrome Helicase is Potently Blocked Upon Encountering a Single Mono-ribonucleotide in the Translocating Strand of a Forked Duplex DNA Substrate
21. Abstract 2677: The SARS-CoV-2 Nsp13 Helicase Required for Coronavirus Replication Interacts with Structured Nucleic Acids in a Strand-Specific Manner and Catalyzes a Novel Protein-RNA Remodeling Activity Implicated in the Proofreading Mechanism of the Replication-Transc
22. List of Contributors
23. Helicases and Their Relevance to Aging
24. Meet the Editorial Board Member
25. DNA Helicases Associated with Genetic Instability, Cancer, and Aging
26. Biochemical analysis of DNA synthesis blockage by G-quadruplex structure and bypass facilitated by a G4-resolving helicase
27. WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer
28. Ageing Research Reviews Special Issue dedicated to women in aging research
29. DNA Repair and Transcription in Premature Aging Syndromes
30. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
31. WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
32. Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes
33. An emerging picture of FANCJ’s role in G4 resolution to facilitate DNA replication
34. Detection of G-quadruplex DNA in mammalian cells
35. Special Issue: DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance
36. DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities
37. FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
38. DNA Helicases Associated with Genetic Instability, Cancer, and Aging
39. DNA helicases and their roles in cancer
40. DNA Helicases Implicated in Chromosomal Instability Disorders as Targets for the Discovery of Novel Anti-Cancer Agents
41. Identification and Biochemical Characterization of a Novel Mutation in DDX11 Causing Warsaw Breakage Syndrome
42. Biochemical characterization of the WRN-FEN-1 functional interaction
43. DNA helicase and helicase–nuclease enzymes with a conserved iron–sulfur cluster
44. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
45. Repeat expansions confer WRN dependence in microsatellite-unstable cancers
46. FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links
47. Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro
48. History of DNA Helicases
49. Ku complex interacts with and stimulates the Werner protein
50. G-quadruplex nucleic acids and human disease
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