32 results on '"Brotschi, Christine"'
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2. Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular Scaffold
3. Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases
4. A Novel, Uniquely Efficacious Type of CFTR Corrector with Complementary Mode of Action
5. Discovery of Nivasorexant (ACT-539313): The First Selective Orexin‑1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials.
6. Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in rats.
7. Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in ratsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00573a
8. Pyrazole derivatives as selective Orexin-2 Receptor Antagonists (2-SORA): Synthesis, Structure-Activity-Relationship, and Sleep-Promoting Properties in Rats
9. A Tethering Mechanism for Length Control in a Processive Carbohydrate Polymerization
10. Front Cover: The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders (ChemMedChem 23/2020)
11. The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders
12. From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs
13. Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats
14. Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2
15. Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1
16. Cover Picture: Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach (ChemMedChem 19/2016)
17. Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach
18. Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists
19. Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist
20. The polymerase activity of a mycobacterial galactofuranosyltransferase suggests a novel mechanism for template‐independent processive polymerization
21. Pentafluorophenyl–Phenyl Interactions in Biphenyl‐DNA
22. Bipyridyl- and Biphenyl-DNA: A Recognition Motif Based on Interstrand Aromatic Stacking
23. RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes
24. Transition Metal Ligands as Novel DNA‐Base Substitutes
25. Transition Metal Ligands as Novel DNA-Base Substitutes
26. DNA mit hydrophobem Basen-Ersatz: ein stabiles reißverschlussartiges Erkennungsmuster durch Interstrang-Basen-Stapelwechselwirkungen
27. DNA with Hydrophobic Base Substitutes: A Stable, Zipperlike Recognition Motif Based On Interstrand‐Stacking Interactions
28. A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor
29. Ein stabiler DNA-Duplex mit einem nichtwasserstoffverbrückenden, nichtformkomplementären Basenpaar: Interstrang-Stapelwechselwirkungen als stabilitätsbestimmender Faktor
30. pentafluorophenyl-phenyl interactions in biphenyl-DNA.
31. Bipyridyl- and biphenyl-DNA: a recognition motif based on interstrand aromatic stacking.
32. DNA with hydrophobic base substitutes: a stable, zipperlike recognition motif based on interstrand-stacking interactions.
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