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1. Fluoroscopic Estimation of Thoracic Dimensional Changes in Healthy Dogs

Author: Chan, JC, Johnson, LR, Brown, CS, and Pollard, RE
Subjects: Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Lung, Respiratory, Animals, Body Weight, Dogs, Female, Fluoroscopy, Male, Prospective Studies, Respiratory Mechanics, Thorax, Dog, Parenchymal disease, Pulmonary function testing, Respiratory tract, Veterinary sciences
Abstract: BackgroundCurrent methods available for assessing alterations in lung mechanics require sophisticated equipment and are of limited availability. A method that could assess lung area change with respiration might be a clinically useful surrogate for assessing lung compliance.ObjectiveTo use fluoroscopy to determine percent change in thoracic and lung areas in healthy dogs.AnimalsForty-four client-owned dogs with no evidence of respiratory disease.MethodsProspective study. Resting respiration was recorded fluoroscopically, and peak inspiratory and expiratory frames were captured for 3 typical respiratory cycles. The number of intrathoracic pixels in the entire thoracic cavity was measured for both inspiration and expiration, and the average percent change in intrathoracic area was determined for each dog. This process was repeated by a hemithorax measurement of lung area that excluded the mediastinum and cardiac silhouette. Proposed reference ranges (and 95% confidence intervals [CI]) were computed by a nonparametric percentile distribution.ResultsMedian percent change in thoracic dimension for the total thorax measurement was 12.5% (CI, 8.9-24.0%). Median percent change for the hemithorax measurement was significantly (P < 0.001) larger (20.8%, CI, 14.3-37.6%). Both measurement techniques were correlated with body weight but not with age, sex, thoracic conformation, body condition score (BCS), or breed.Conclusions and clinical importanceFluoroscopy allows a noninvasive and repeatable measure of lung area changes during respiration that must be corrected for body weight. Additional studies in dogs with respiratory diseases are needed to determine its utility in detecting clinically useful alterations in lung area changes.
Published: 2017

2. Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021

Author: Vollset, SE, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, AHA, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdullahi, A, Abebe, M, Abiodun, O, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Absalan, A, Abualruz, H, Abubakar, B, Abukhadijah, HJJ, Addolorato, G, Adekanmbi, V, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adhikary, RK, Adnani, QES, Adzigbli, LA, Afrashteh, F, Afzal, MS, Afzal, S, Agbozo, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahlstrom, AJ, Ahmad, A, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmed, A, Ahmed, H, Ahmed, S, Ahmed, SA, Akinosoglou, K, Akkaif, MA, Akrami, AE, Akter, E, Al Awaidy, S, Al Hasan, SM, Al Mosa, AS, Al Ta'ani, O, Al Zaabi, OAM, Alahdab, F, Alajlani, MM, Al-Ajlouni, Y, Alalalmeh, SO, Al-Aly, Z, Alam, K, Alam, N, Alam, T, Alam, Z, Al-Amer, RM, Alanezi, FM, Alanzi, TM, Albakri, A, Aldhaleei, WA, Aldridge, RW, Alemohammad, SY, Alemu, YM, Al-Gheethi, AAS, Al-Hanawi, MK, Ali, A, Ali, I, Ali, MU, Ali, R, Ali, SSS, Ali, VE, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Almazan, JU, Al-Mekhlafi, HM, Alqutaibi, AY, Alrawashdeh, A, Alrousan, SM, Al-Sabah, SK, Alsabri, MA, Altaany, Z, Al-Tammemi, AB, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Alyahya, MS, Alzoubi, KH, Al-Zyoud, W, Amani, R, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Andrews, EA, Anil, A, Anil, S, Anoushiravani, A, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, S, Anyasodor, AE, Appiah, F, Aquilano, M, Arab, JP, Arabloo, J, Arafa, EA, Arafat, M, Aravkin, AY, Ardekani, A, Areda, D, Aregawi, BB, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, AA, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, AW, Ayatollahi, H, Ayuso-Mateos, JL, Azadnajafabad, S, Azeez, FK, Azevedo, RMS, Badar, M, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, JL, Bako, AT, Balakrishnan, S, Balcha, WF, Baltatu, OC, Barchitta, M, Bardideh, E, Barker-Collo, SL, Barnighausen, TW, Barqawi, HJ, Barteit, S, Basiru, A, Basso, JD, Bastan, M-M, Basu, S, Bauckneht, M, Baune, BT, Bayati, M, Bayileyegn, NS, Behnoush, AH, Behzadi, P, Beiranvand, M, Bello, OO, Belo, L, Beloukas, A, Bemanalizadeh, M, Bensenor, IM, Benzian, H, Beran, A, Berezvai, Z, Bernstein, RS, Bettencourt, PJG, Beyene, KA, Beyene, MG, Bhagat, DS, Bhagavathula, AS, Bhala, N, Bhandari, D, Bharadwaj, R, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhattacharjee, NV, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhuiyan, MA, Bisignano, C, Biswas, B, Bjorge, T, Bodolica, V, Bodunrin, AO, Hashemi, MB, Basara, BB, Borhany, H, Bosoka, SA, Carvajal, AB, Bouaoud, S, Boufous, S, Boxe, C, Boyko, EJ, Brady, OJ, Braithwaite, D, Brauer, M, Brazo-Sayavera, J, Brenner, H, Brown, CS, Browne, AJ, Brugha, T, Bryazka, D, Bulamu, NB, Buonsenso, D, Burkart, K, Burns, RA, Busse, R, Bustanji, Y, Butt, ZA, dos Santos, FLC, Barsbay, MC, Calina, D, Campos, LA, Cao, S, Capodici, A, Cardenas, R, Carreras, G, Carugno, A, Carvalho, M, Castaldelli-Maia, JM, Castelpietra, G, Cattaruzza, MS, Caye, A, Cegolon, L, Cembranel, F, Cenko, E, Cerin, E, Chadban, SJ, Chadwick, J, Chakraborty, C, Chakraborty, S, Chalek, J, Chan, JSK, Chandika, RM, Chandy, S, Charan, J, Chaudhary, AA, Chaurasia, A, Chen, A-T, Chen, H, Chen, MX, Chen, S, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Chimoriya, R, Ching, PR, Chirinos-Caceres, JL, Chitheer, A, Cho, DY, Cho, WCS, Choi, D-W, Chong, B, Chong, CL, Chopra, H, Chu, D-T, Chung, E, Chutiyami, M, Clayton, JT, Cogen, RM, Cohen, AJ, Columbus, A, Comfort, H, Conde, J, Connolly, JT, Cooper, EEK, Cortese, S, Cruz-Martins, N, da Silva, AG, Dadras, O, Dai, X, Dai, Z, Dalton, BE, Damiani, G, Dandona, L, Dandona, R, Das, JK, Das, S, Dash, NR, Davletov, K, De la Hoz, FP, De Leo, D, Debopadhaya, S, Delgado-Enciso, I, Denova-Gutierrez, E, Dervenis, N, Desai, HD, Devanbu, VGC, Dewan, SMR, Dhama, K, Dhane, AS, Dhingra, S, da Silva, DD, Diaz, D, Diaz, LA, Diaz, MJ, Dima, A, Ding, DD, Do, THP, Do Prado, CB, Dodangeh, M, Doegah, PT, Dohare, S, Dong, W, D'Oria, M, Doshi, R, Dowou, RK, Dsouza, HL, Dsouza, V, Dube, J, Dumith, SC, Duncan, BB, Duraes, AR, Duraisamy, S, Durojaiye, OC, Dushpanova, A, Dutta, S, Dzianach, PA, Dziedzic, AM, Eboreime, E, Ebrahimi, A, Kalan, ME, Edinur, HA, Efendi, F, Eikemo, TA, Eini, E, Ekundayo, TC, El Arab, RA, El Sayed, I, Elamin, O, Elemam, NM, ElGohary, GMT, Elhadi, M, Elmeligy, OAA, Elmoselhi, AB, Elshaer, M, Elsohaby, I, Eltahir, ME, Emeto, TI, Eshrati, B, Eslami, M, Esmaeili, Z, Fabin, N, Fagbamigbe, AF, Fagbule, OF, Falzone, L, Fareed, M, Farinha, CSES, Faris, MEM, Faro, A, Fasihi, K, Fatehizadeh, A, Fauk, NK, Fazylov, T, Feigin, VL, Fekadu, G, Feng, X, Fereshtehnejad, S-M, Ferrara, P, Ferreira, N, Firew, BS, Fischer, F, Fitriana, I, Flavel, J, Flor, LS, Folayan, MO, Foley, KM, Fonzo, M, Force, LM, Foschi, M, Freitas, A, Fridayani, NKY, Fukutaki, KG, Furtado, JM, Fux, B, Gaal, PA, Gadanya, MA, Gallus, S, Ganesan, B, Ganiyani, MA, Gautam, RK, Gebi, TG, Gebregergis, MW, Gebrehiwot, M, Getacher, L, Getahun, GKA, Gething, PW, Ghadimi, DJ, Ghadirian, F, Ghafarian, S, Ghailan, KY, Ghasemi, M, Dabaghi, GG, Ghazy, RM, Ghoba, S, Gholami, E, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Vajargah, PG, Ghotbi, E, Gil, AU, Gill, TK, Girmay, A, Glasbey, JC, Glushkova, EV, Gnedovskaya, EV, Gobolos, L, Goldust, M, Goleij, P, Golinelli, D, Gopalani, SV, Goulart, AC, Gouravani, M, Goyal, A, Grivna, M, Grosso, G, Guarducci, G, Gubari, MIM, Guicciardi, S, Guimaraes, RA, Gulati, S, Gulisashvili, D, Gunawardane, DA, Guo, C, Gupta, AK, Gupta, R, Gupta, S, Gupta, VK, Haakenstad, A, Hadi, NR, Haep, N, Hafiz, A, Haghmorad, D, Haile, D, Ali, AH, Ali, HA, Haj-Mirzaian, A, Halboub, ES, Haller, S, Halwani, R, Abdullah, KH, Hamdy, NM, Hamoudi, R, Hanifi, N, Hankey, GJ, Haq, ZA, Haque, MR, Harapan, H, Hargono, A, Haro, JM, Hasaballah, AI, Hasan, SMM, Hasanian, M, Hasnain, MS, Hassan, A, Haubold, J, Hay, SI, Hebert, JJ, Hegazi, OE, Heidari, M, Hemmati, M, Henson, CA, Herrera-Serna, BY, Herteliu, C, Heydari, M, Hezam, K, Hidayana, I, Hiraike, Y, Hoan, NQ, Holla, R, Hoogar, P, Horita, N, Hossain, MM, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hu, C, Huang, J, Hultstrom, M, Hundie, TG, Hunt, AJ, Hushmandi, K, Hussain, J, Hussain, MA, Hussein, NR, Huynh, H-H, Hwang, B-F, Ibitoye, SE, Iftikhar, PM, Ikiroma, AI, Ikwegbue, PC, Ilic, IM, Ilic, MD, Immurana, M, Isa, MA, Islam, MR, Islam, SMS, Ismail, F, Ismail, NE, Isola, G, Iwagami, M, Iyamu, IO, Jacob, L, Jacobsen, KH, Jafarinia, M, Jahankhani, K, Jahanmehr, N, Jain, N, Jairoun, AA, Mani, DRJ, Jamil, S, Jamora, RDG, Jatau, AI, Javadov, S, Javaheri, T, Jayaram, S, Jee, SH, Jeganathan, J, Jiang, H, Jokar, M, Jonas, JB, Joseph, N, Joshua, CE, Jurisson, M, Vaishali, K, Kabir, A, Kabir, Z, Kadashetti, V, Kalankesh, LR, Kalra, S, Kamath, A, Kamath, R, Kamireddy, A, Kanaan, M, Kanchan, T, Kanmiki, EW, Kanmodi, KK, Kansal, SK, Karim, A, Karkhah, S, Kashoo, FZ, Kasraei, H, Kassel, MB, Katikireddi, SV, Kauppila, JH, Kaur, H, Kayode, GA, Kazemi, F, Kazemian, S, Kebede, F, Kendal, ES, Kesse-Guyot, E, Khademvatan, S, Khajuria, H, Khalaji, A, Khalid, A, Khalid, N, Khalilian, A, Khamesipour, F, Khan, F, Khan, MJ, Khan, MAB, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, MM, Khatib, MN, Kashani, HRK, Kheirallah, KA, Khokhar, M, Khormali, M, Khorrami, Z, Khosla, AA, Khosravi, M, Khosrowjerdi, M, Khubchandani, J, Kifle, ZD, Kim, G, Kim, JS, Kim, MS, Kim, YJ, Kimokoti, RW, Kisa, A, Kisa, S, Knibbs, LD, Knudsen, AKS, Kochhar, S, Kolahi, A-A, Kompani, F, Koren, G, Korzh, O, Krishan, K, Krishna, V, Krishnamoorthy, V, Bicer, BK, Kuddus, MA, Kuddus, M, Kuitunen, I, Kujan, O, Kulimbet, M, Kulkarni, V, Kumar, GA, Kumar, H, Kumar, N, Kumar, R, Kumar, V, Kundu, A, Kusuma, D, Kyei-Arthur, F, Kyto, V, Kyu, HH, La Vecchia, C, Lacey, B, Ladan, MA, Laflamme, L, Lahariya, C, Lai, DTC, Lalloo, R, Lallukka, T, Lam, J, Lan, Q, Lan, T, Landires, I, Lanfranchi, F, Langguth, B, Lansingh, VC, Laplante-Levesque, A, Larijani, B, Larsson, AO, Lasrado, S, Lauriola, P, Lawlor, HR, Le, H-H, Le, LKD, Le, NHH, Le, TTT, Le, TDT, Leasher, JL, Lee, DW, Lee, M, Lee, PH, Lee, S-W, Lee, SW, Lee, SWH, Lee, YH, Leigh, J, Leong, E, Li, M-C, Libra, M, Ligade, VS, Lim, L-L, Lim, SS, Limenh, LW, Lindholm, D, Lindstedt, PA, Listl, S, Liu, G, Liu, S, Liu, X, Llanaj, E, Lopez-Bueno, R, Lopez-Gil, JF, Loreche, AM, Lotufo, PA, Lozano, R, Lubinda, J, Lucchetti, G, Luo, L, Lusk, JB, Lv, L, Amin, HIM, Ma, ZF, Maass, KL, Machairas, N, Machoy, M, Madureira-Carvalho, AM, Abd El Razek, HM, Maghazachi, AA, Prasad, DRM, Mahalleh, M, Mahasha, PW, Mahmoud, MA, Mahmoudi, E, Mahmoudvand, G, Makama, M, Rad, EM, Malhotra, K, Malik, AA, Malta, DC, Manla, Y, Mansour, A, Mansouri, MH, Mansouri, P, Mansouri, V, Mansourian, M, Mansournia, MA, Marasini, BP, Marateb, HR, Maravilla, JC, Mardi, P, Marjani, A, Moghadam, HM, Arnedo, CAM, Martinez, G, Martinez-Piedra, R, Martins-Melo, FR, Martorell, M, Marx, W, Marzo, RR, Masoudi, S, Mathangasinghe, Y, Mathioudakis, AG, Mathur, M, Mathur, N, Matozinhos, FP, Mattumpuram, J, Maude, RJ, Maugeri, A, Mayeli, M, Mazidi, M, Mazzotti, A, McGrath, JJ, Mckee, M, McKowen, ALW, McPhail, MA, McPhail, SM, Mehmood, A, Mehrabani-Zeinabad, K, Mehravar, S, Meto, TM, Melese, EB, Mendez-Lopez, MAM, Mendoza, W, Menezes, RG, Mensah, GA, Mensah, LG, Mentis, A-FA, Meo, SA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mestrovic, T, Mettananda, KCD, Mettananda, S, Mhlanga, A, Mhlanga, L, Miazgowski, T, Michalek, IM, de Sa, ACMGN, Miller, TR, Minh, LHN, Mirahmadi, A, Mirijello, A, Mirrakhimov, EM, Mirzaei, R, Mitchell, PB, Mittal, C, Moberg, ME, Fard, AM, Mohajelin, S, Mohamadkhani, A, Mohamed, AI, Mohamed, J, Mohamed, MFH, Mohamed, NS, Mohammad, AM, Mohammadi, S, Mohammed, H, Mohammed, M, Mohammed, S, Mokdad, AH, Molokhia, M, Momani, SM, Momtazmanesh, S, Monasta, L, Mondello, S, Moni, MA, Montazeri, F, Ghalibaf, AM, Moradi, M, Moradi, Y, Moraga, P, Morawska, L, Moreira, RS, Morovatdar, N, Morrison, SD, Mosapour, A, Mosser, JF, Mossialos, E, Motappa, R, Mougin, V, Mousavi, P, Mrejen, M, Mubarik, S, Mueller, UO, Mulita, F, Munjal, K, Murillo-Zamora, E, Musallam, KM, Musina, A-M, Mustafa, G, Myung, W, Nafei, A, Nagarajan, AJ, Naghavi, P, Naik, GR, Naik, G, Nainu, F, Najdaghi, S, Ansari, NN, Nangia, V, Swamy, SN, Nargus, S, Davani, DN, Nascimento, BR, Nascimento, GG, Naser, AY, Nashwan, AJ, Natto, ZS, Nauman, J, Navaratna, SNK, Naveed, M, Nawsherwan, Nayak, BP, Nayak, VC, Negash, H, Negoi, I, Negoi, RI, Nejadghaderi, SA, Nejjari, C, Nematollahi, S, Netsere, HB, Ng, M, Nguefack-Tsague, G, Ngunjiri, JW, Nguyen, AH, Nguyen, DH, Nguyen, HTH, Nguyen, N, Nguyen, NNY, Nguyen, PT, Nguyen, QP, Nguyen, VT, Minh, DNT, Niazi, RK, Nigatu, YT, Niknam, M, Nikoobar, A, Nikpoor, AR, Nikravangolsefid, N, Noman, EA, Nomura, S, Noor, STA, Noroozi, N, Nouri, M, Nozari, M, Nri-Ezedi, CA, Ntaios, G, Nunemo, MH, Nurrika, D, Nutor, JJ, Nzoputam, CI, Nzoputam, OJ, Oancea, B, Obamiro, KO, Odetokun, IA, Oduro, MS, Ogundijo, OA, Ogunfowokan, AA, Ogunkoya, A, Oguntade, AS, Oh, I-H, Ojo-Akosile, TR, Okati-Aliabad, H, Okekunle, AP, Okonji, OC, Olagunju, AT, Olatubi, MI, Oliveira, GMM, Olusanya, BO, Olusanya, JO, Oluwafemi, YD, Omar, HA, Omer, GL, Ong, S, Onie, S, Onwujekwe, OE, Opejin, AO, Ordak, M, Orish, VN, Ortiz, A, Ortiz-Prado, E, Osman, WMS, Ostojic, SM, Ostroff, SM, Osuagwu, UL, Otoiu, A, Otstavnov, SS, Ouyahia, A, Owolabi, MO, Oyeyemi, OT, Ozair, A, Padukudru, MPA, Padron-Monedero, A, Padubidri, JR, Pal, PK, Palicz, T, Pan, F, Pan, H-F, Panda-Jonas, S, Pandey, A, Pando-Robles, V, Pangaribuan, HU, Panos, GD, Panos, LD, Pantazopoulos, I, Stoian, AMP, Parikh, RR, Park, E-K, Park, S, Parsons, N, Parthasarathi, A, Pasovic, M, Passera, R, Patel, J, Pathan, AR, Patil, S, Patoulias, D, Pawar, S, Toroudi, HP, Pease, SA, Peden, AE, Pedersini, P, Pensato, U, Pepito, VCF, Peprah, P, Pereira, M, Pereira, MO, Perianayagam, A, Perico, N, Perna, S, Pesudovs, K, Petermann-Rocha, FE, Pham, HT, Philip, AK, Phillips, MR, Pigeolet, M, Piradov, MA, Pisoni, E, Plotnikov, E, Poddighe, D, Polibin, RV, Poluru, R, Ponkilainen, VT, Popovic, DS, Postma, MJ, Pour-Rashidi, A, Prabhu, D, Prada, SI, Pradhan, J, Pradhan, PMS, Prashant, A, Prates, EJS, Priscilla, T, Purnobasuki, H, Purohit, BM, Puvvula, J, Qasim, NH, Qattea, I, Qazi, AS, Qian, G, Rad, MR, Radhakrishnan, V, Shahraki, HR, Rafferty, Q, Raggi, A, Raggi, C, Raheem, N, Rahim, F, Rahim, MJ, Rahimibarghani, S, Rahman, MMMR, Rahman, M, Rahman, MA, Rahman, T, Rahmani, AM, Rahmanian, M, Rahmanian, N, Rahmati, R, Rahmawaty, S, Raimondo, D, Raja, A, Rajput, P, Ramadan, M, Ramasamy, SK, Ramazanu, S, Ramteke, PW, Rana, K, Rana, RK, Ranabhat, CL, Rane, A, Rao, CR, Rao, M, Rasella, D, Rashedi, V, Rashid, AM, Rasouli-Saravani, A, Rastogi, P, Rasul, A, Rathish, D, Babu, GR, Rauniyar, SK, Ravangard, R, Rawaf, DL, Rawaf, S, Raza, RZ, Redwan, EMM, Reifels, L, Reitsma, MB, Remuzzi, G, Rengasamy, KRR, Reshmi, B, Resnikoff, S, Restaino, S, Reyes, LF, Rezaei, N, Rezaei, ZS, Rezaeian, M, Rhee, TG, Rickard, J, Robalik, T, Robinson-Oden, HE, Rocha, HAL, Rodrigues, M, Rodriguez, JAB, Roever, L, Romadlon, DS, Ronfani, L, Rony, MKK, Roshandel, G, Rotimi, K, Rout, HS, Roy, B, Rubagotti, E, Ruela, GDA, Rumisha, SF, Runghien, T, Russo, M, Saad, AMA, Saber, K, Saber-Ayad, MM, Sabet, CJ, Sabour, S, Sachdev, PS, Saddler, A, Sadee, BA, Sadeghi, M, Saeb, MR, Saeed, U, Safi, SZ, Sagar, R, Saghafi, A, Sagoe, D, Sahebkar, A, Sahoo, PM, Sajid, MR, Salam, N, Salamati, P, Salami, AA, Saleh, MA, Salehi, L, Salem, MR, Salemcity, AJ, Salimi, S, Kafil, HS, Samargandy, S, Samodra, YL, Samy, AM, Sanabria, J, Sanna, 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Abstract: BACKGROUND: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. METHODS: Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. All analyses were done at the cause-specific level so that only risk factors deemed causal by the GBD comparative risk assessment influenced future trajectories of mortality for each disease. Cause-specific mortality was modelled using mixed-effects models with SDI and time as the main covariates, and the combined impact of causal risk factors as an offset in the model. At the all-cause mortality level, we captured unexplained variation by modelling residuals with an autoregressive integrated moving average model with drift attenuation. These all-cause forecasts constrained the cause-specific forecasts at successively deeper levels of the GBD cause hierarchy using cascading mortality models, thus ensuring a robust estimate of cause-specific mortality. For non-fatal measures (eg, low back pain), incidence and prevalence were forecasted from mixed-effects m
Published: 2024

3. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Author: Brauer, M, Roth, GA, Aravkin, AY, Zheng, P, Abate, KH, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasi, MA, Abbasian, M, Abbasifard, M, Moradi, Y, Bensenor, IM, Benzian, H, Beran, A, Abouzid, M, Berezvai, Z, Bernabe, E, Bernstein, RS, Bettencourt, PJG, Bhagavathula, AS, Bhala, N, Moraga, P, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Aboye, GB, Bhat, AN, Bhat, V, Bhatti, GK, Bhatti, JS, Bhatti, MS, Morawska, L, Bhatti, R, Bhuiyan, MA, Bhutta, ZA, Bikbov, B, Bishai, JD, Abreu, LG, Bisignano, C, Biswas, A, Biswas, B, Biswas, RK, Moreira, RS, Bjørge, T, Boachie, MK, Boakye, H, Bockarie, MJ, Bodolica, V, Bodunrin, AO, Abualruz, H, Bogale, EK, Bolla, SR, Boloor, A, Morovatdar, N, Bonakdar Hashemi, M, Boppana, SH, Bora Basara, B, Borhany, H, Botero Carvajal, A, Bouaoud, S, Boufous, S, Abubakar, B, Bourne, R, Boxe, C, Morrison, SD, Braithwaite, D, Brant, LC, Brar, A, Breitborde, NJK, Breitner, S, Brenner, H, Briko, AN, Britton, G, Abu-Gharbieh, E, Brown, CS, Morze, J, Browne, AJ, Brunoni, AR, Bryazka, D, Bulamu, NB, Bulto, LN, Buonsenso, D, Burkart, K, Burns, RA, Busse, R, Abukhadijah, HJJ, Mosaddeghi Heris, R, Bustanji, Y, Butt, NS, Butt, ZA, Caetano dos Santos, FL, Cagney, J, Cahuana-Hurtado, L, Calina, D, Cámera, LA, Campos, LA, Campos-Nonato, IR, Mossialos, E, Aburuz, S, Cao, C, Cao, F, Cao, Y, Capodici, A, Cárdenas, R, Carr, S, Carreras, G, Carrero, JJ, Carugno, A, Motappa, R, Carvalho, F, Abu-Zaid, A, Carvalho, M, Castaldelli-Maia, JM, Castañeda-Orjuela, CA, Castelpietra, G, Catalá-López, F, Catapano, AL, Cattaruzza, MS, Caye, A, Alemayohu, MA, Ali, BA, Cederroth, CR, Cegolon, L, Adane, MM, Cenderadewi, M, Cercy, KM, Cerin, E, Chadwick, J, Chakraborty, C, Chakraborty, PA, Chakraborty, S, Mougin, V, Chan, JSK, Chan, RNC, Chandan, JS, Addo, IY, Chandika, RM, Chaturvedi, P, Chen, A-T, Chen, CS, Chen, H, Chen, MX, Mousavi, P, Chen, M, Chen, S, Cheng, C-Y, Cheng, ETW, Addolorato, G, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Chimoriya, 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EM, Stanaway, JD, Stanikzai, MH, Stein, C, Anderlini, D, Stein, DJ, Steinbeis, F, Steiner, C, Steinke, S, Steiropoulos, P, Stockfelt, L, Mirshahi, A, Stokes, MA, Straif, K, Stranges, S, Subedi, N, Anderson, JA, Subramaniyan, V, Suleman, M, Suliankatchi Abdulkader, R, Sundström, J, Sunkersing, D, Alhabib, KF, Sunnerhagen, KS, Suresh, V, Swain, CK, Szarpak, L, Szeto, MD, Andrade, PP, Tabaee Damavandi, P, Tabarés-Seisdedos, R, Tabatabaei, SM, Tabatabaei Malazy, O, Mirzaei, M, Tabatabaeizadeh, S-A, Tabatabai, S, Tabche, C, Tabish, M, Tadakamadla, SK, Taheri Abkenar, Y, Abdoun, M, Andrei, CL, Taheri Soodejani, M, Taherkhani, A, Mishra, AK, Taiba, J, Takahashi, K, Talaat, IM, Tamuzi, JL, Tan, K-K, Tang, H, Tat, NY, Taveira, N, Andrei, T, Tefera, YM, Mishra, V, Tehrani-Banihashemi, A, Temesgen, WA, Temsah, M-H, Teramoto, M, Terefa, DR, Teye-Kwadjo, E, Thakur, R, Thangaraju, P, Thankappan, KR, Anenberg, SC, Mitchell, PB, Thapar, R, Thayakaran, R, Thirunavukkarasu, S, Thomas, N, Thomas, NK, Tian, J, Tichopad, A, Ticoalu, JHV, Tiruye, TY, Tobe-Gai, R, Mithra, P, Angappan, D, Tolani, MA, Tolossa, T, Tonelli, M, Topor-Madry, R, Topouzis, F, Touvier, M, Tovani-Palone, MR, Trabelsi, K, Tran, JT, Mittal, C, Tran, MTN, Angus, C, Tran, NM, Trico, D, Trihandini, I, Troeger, CE, Tromans, SJ, Truyen, TTTT, Tsatsakis, A, Tsermpini, EE, Moazen, B, Tumurkhuu, M, Udoakang, AJ, Anil, A, Udoh, A, Ullah, A, Ullah, S, Umair, M, Umakanthan, S, Unim, B, Moberg, ME, Unnikrishnan, B, Upadhyay, E, Urso, D, Anil, S, Usman, JS, Vaithinathan, AG, Vakili, O, Valenti, M, Valizadeh, R, Van den Eynde, J, Mocciaro, G, van Donkelaar, A, Varga, O, Vart, P, Varthya, SB, Anjum, A, Vasankari, TJ, Vasic, M, Vaziri, S, Venketasubramanian, N, Verghese, NA, Mohamadkhani, A, Verma, M, Veroux, M, Verras, G-I, Vervoort, D, Villafañe, JH, Anoushiravani, A, Villalobos-Daniel, VE, Villani, L, Villanueva, GI, Vinayak, M, Alhassan, RK, Violante, FS, Vlassov, V, Vo, B, Vollset, SE, Volovat, SR, Vos, T, Antonazzo, IC, Vujcic, IS, Waheed, Y, Wang, C, Mohamed, AZ, Wang, F, Wang, S, Wang, Y, Wang, Y-P, Wanjau, MN, Waqas, M, Ward, P, Abdulah, DM, Antony, CM, Waris, A, Mohamed, AI, Wassie, EG, Weerakoon, KG, Weintraub, RG, Weiss, DJ, Weiss, EJ, Weldetinsaa, HLL, Wells, KM, Wen, YF, Wiangkham, T, Antriyandarti, E, Mohamed, J, Wickramasinghe, ND, Wilkerson, C, Willeit, P, Wilson, S, Wong, YJ, Wongsin, U, Wozniak, S, Wu, C, Wu, D, Wu, F, Mohamed, MFH, Anuoluwa, BS, Wu, Z, Xia, J, Xiao, H, Xu, S, Xu, X, Xu, YY, Yadav, MK, Yaghoubi, S, Yamagishi, K, Mohamed, NS, Yang, L, Anvari, D, Yano, Y, Yaribeygi, H, Yasufuku, Y, Ye, P, Yesodharan, R, Yesuf, SA, Yezli, S, Yi, S, Mohammadi, E, Yiğit, A, Yigzaw, ZA, Anvari, S, Yin, D, Yip, P, Yismaw, MB, Yon, DK, Yonemoto, N, You, Y, Younis, MZ, Mohammadi, S, Yousefi, Z, Yu, C, Yu, Y, Anwar, S, Zadey, S, Zadnik, V, Zakham, F, Zaki, N, Zakzuk, J, Zamagni, G, Mohammadian-Hafshejani, A, Zaman, SB, Zandieh, GGZ, Zanghì, A, Zar, HJ, Anwar, SL, Zare, I, Zarimeidani, F, Zastrozhin, MS, Zeng, Y, Zhai, C, Mohammadifard, N, Zhang, AL, Zhang, H, Zhang, L, Zhang, M, Zhang, Y, Anwer, R, Zhang, Z, Zhang, Z-J, Zhao, H, Zhao, JT, Mohammed, H, Zhao, X-JG, Zhao, Y, Zhong, C, Zhou, J, Anyabolo, EE, Zhou, S, Zhu, B, Zhu, L, Ali, A, Zhu, Z, Ziaeian, B, Ziafati, M, Zielińska, M, Zimsen, SRM, Zoghi, G, Zoller, T, Anyasodor, AE, Zumla, A, Zyoud, SH, Mohammed, M, Murray, CJL, Gakidou, E, Abdullahi, A, Apostol, GLC, Arabloo, J, Arabzadeh Bahri, R, Arafat, M, Areda, D, Aregawi, BB, Mohammed, S, Aremu, A, Armocida, B, Arndt, MB, Ärnlöv, J, Abebe, M, Arooj, M, Artamonov, AA, Artanti, KD, Aruleba, IT, Arumugam, A, Asbeutah, AM, Asgary, S, Asgedom, AA, Ashbaugh, C, Ashemo, MY, Abedi, A, Ashraf, T, Askarinejad, A, Assmus, M, Astell-Burt, T, Mokdad, AH, Athar, M, Athari, SS, Atorkey, P, Atreya, A, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awoke, AA, Ayala Quintanilla, BP, Monasta, L, Ayatollahi, H, Ayestas Portugal, C, Ayuso-Mateos, JL, Azadnajafabad, S, Azevedo, RMS, Azhar, GS, Azizi, H, Abegaz, TM, Azzam, AY, Backhaus, IL, Mondello, S, Badar, M, Badiye, AD, Bagga, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bahrami Taghanaki, P, Bai, R, Abeldaño Zuñiga, RA, Baig, AA, Moni, MA, Baker, JL, Bakkannavar, SM, Balasubramanian, M, Baltatu, OC, Bam, K, Bandyopadhyay, S, Banik, B, Banik, PC, Banke-Thomas, A, Abiodun, O, Moodi Ghalibaf, A, Bansal, H, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barone-Adesi, F, Barqawi, HJ, Barrero, LH, Barrow, A, Moore, CE, Abiso, TL, Barteit, S, Basharat, Z, Basiru, A, Basso, JD, Bastan, M-M, Basu, S, Batchu, S, Batra, K, Batra, R, Moradi, M, Baune, BT, Aboagye, RG, Bayati, M, Bayileyegn, NS, Beaney, T, Behnoush, AH, Beiranvand, M, Béjot, Y, Bekele, A, Belgaumi, UI, Bell, AW, Bell, ML, Abolhassani, H, Bello, MB, Bello, OO, Belo, L, Beloukas, A, Bendak, S, Bennett, DA, and Bennitt, FB
Published: 2024

4. UNIVERSAL ANTENATAL CULTURE-BASED SCREENING FOR MATERNAL GROUP B STREPTOCOCCUS (GBS) CARRIAGE TO PREVENT EARLY-ONSET GBS DISEASE : A SYSTEMATIC REVIEW FOR THE UK NATIONAL SCREENING COMMITTEE (NSC)

Author: Seedat, F, Geppert, J, Stinton, C, Patterson, J, Brown, CS, Tan, B, Freeman, K, Uthman, OA, McCarthy, ND, Robinson, ER, Johnson, SA, Fraser, H, Clarke, A, and Taylor-Phillips, SA
Published: 2017

5. Improving maternal outcomes through early recognition, rapid notification, and investigation of invasive GAS infection

Author: Lamagni, T, Guy, RL, Sriskandan, S, Decraene, V, and Brown, CS
Published: 2023

6. Trends in coagulase-negative staphylococci (CoNS), England, 2010-2021

Author: Paranthaman, K, Wilson, A, Verlander, N, Rooney, G, Macdonald, N, Nsonwu, O, Hope, R, Fleming, P, Hatcher, J, Ogundipe, E, Ratnaraja, N, Wan, Y, Pichon, B, Westrop, SJ, Brown, CS, and Demirjian, A
Abstract: OBJECTIVE: To review the epidemiology of coagulase-negative staphylococci (CoNS) in England over the recent 12 year period. METHODS: Laboratory-confirmed CoNS reported from sterile sites in patients in England to the UK Health Security Agency (UKHSA) between 2010 and 2021 were extracted from the national laboratory database and analysed. RESULTS: Overall, 668 857 episodes of CoNS were reported. Unspeciated CoNS accounted for 56 % (374 228) of episodes, followed by Staphylococcus epidermidis (26 %; 174 050), S. hominis (6.5 %; 43 501) and S. capitis (3.9 %; 25 773). Unspeciated CoNS increased by 8.2 % (95 % CI, 7.1-9.3) annually between 2010 and 2016, then decreased annually by 6.4 % (95 % CI: -4.8 to -7.9) until 2021. Speciated CoNS increased by 47.6 % (95 % CI, 44.5-50.9) annually between 2010 and 2016 and increased annually by 8.9 % (95 % CI: 5.1 to 12.8) until 2021. Antimicrobial susceptibility profiles differed by species. CONCLUSIONS: Reports of CoNS from normally sterile body sites in patients in England increased between 2010 and 2016 and remained stable between 2017 and 2021. There has been a striking improvement in species-level identification of CoNS in recent years. Monitoring trends in CoNS epidemiology is crucial for development of observational and clinical intervention studies on individual species.
Published: 2023

7. OP34 Universal antenatal culture-based screening for maternal group b streptococcus (gbs) carriage to prevent early-onset gbs disease: a systematic review for the uk national screening committee (nsc)

Author: Seedat, F, Geppert, J, Stinton, C, Patterson, J, Brown, CS, Tan, B, Freeman, K, Uthman, OA, McCarthy, ND, Robinson, ER, Johnson, SA, Fraser, H, Clarke, A, and Taylor-Phillips, SA
Published: 2017
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8. Assessing the added value of group B Streptococcus maternal immunisation in preventing maternal infection and fetal harm: population surveillance study

Author: Lamagni, T, primary, Wloch, C, additional, Broughton, K, additional, Collin, SM, additional, Chalker, V, additional, Coelho, J, additional, Ladhani, SN, additional, Brown, CS, additional, Shetty, N, additional, and Johnson, AP, additional
Published: 2021
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9. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author: Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Saei, Ayoub, additional, Andrews, Nick, additional, Oguti, Blanche, additional, Charlett, Andre, additional, Wellington, Edgar, additional, Stowe, Julia, additional, Gillson, Natalie, additional, Atti, Ana, additional, Islam, Jasmin, additional, Karagiannis, Ioannis, additional, Munro, Katie, additional, Khawam, Jameel, additional, Chand, Meera A, additional, Brown, Colin S, additional, Ramsay, Mary, additional, Lopez-Bernal, Jamie, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Roynon, A, additional, Northfield, J, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Bakker, P, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes,, T, additional, Jones, C, additional, Osuji, N, additional, Chitalia, N, additional, Bailey, T, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Brake, S, additional, Gunn, J, additional, Selassi, A, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Lewis, T, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Aeron-Thomas, J, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Shah, A, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westwell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Horsley, A, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Flanagan, D, additional, Dhasmana, D, additional, Fowler, S, additional, Cameron, E, additional, Prentice, L, additional, Sinclair, C, additional, Bateman, V, additional, McLelland-Brooks, K, additional, Ho, A, additional, Murphy, M, additional, Cochrane, A, additional, Gibson, A, additional, Black, K, additional, Tempeton, K, additional, Donaldson, S, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Cross, A, additional, Mirfenderesky, M, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Cowling, P, additional, Brazil, M, additional, Hanna, E, additional, Abdelrazik, A, additional, Brand, S, additional, Sheridan, EA, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Browne, D, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Warren, S, additional, Brooking, D, additional, Pai, S, additional, Druyeh, R, additional, Smith, E, additional, Stone, S, additional, Meisner, S, additional, Delgado, D, additional, Underhill, E, additional, Keen, L, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Birch, S, additional, DeSilva, T, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Painter, Sharen, additional, Price, C, additional, Pepperell, J, additional, James, K, additional, Trinick, T, additional, Moore, L, additional, Day, J, additional, Boulos, A, additional, Knox, I, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Bain, SC, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, White, N, additional, Longfellow, R, additional, Hughes, LE, additional, Green, ME, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Hilton, D, additional, Powell, J, additional, Jackson, A, additional, Plant, AJ, additional, Ahmed, N, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, RE, additional, Donaghy, T, additional, O'Kane, M, additional, Shipman, K, additional, Sierra, R, additional, Parmar, C, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, Baxendale, H, additional, and Heeney, JL, additional
Published: 2021
Full Text: View/download PDF

10. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)

Author: Hall, Victoria Jane, primary, Foulkes, Sarah, additional, Charlett, Andre, additional, Atti, Ana, additional, Monk, Edward J M, additional, Simmons, Ruth, additional, Wellington, Edgar, additional, Cole, Michelle J, additional, Saei, Ayoub, additional, Oguti, Blanche, additional, Munro, Katie, additional, Wallace, Sarah, additional, Kirwan, Peter D, additional, Shrotri, Madhumita, additional, Vusirikala, Amoolya, additional, Rokadiya, Sakib, additional, Kall, Meaghan, additional, Zambon, Maria, additional, Ramsay, Mary, additional, Brooks, Tim, additional, Brown, Colin S, additional, Chand, Meera A, additional, Hopkins, Susan, additional, Andrews, N, additional, Atti, A, additional, Aziz, H, additional, Brooks, T, additional, Brown, CS, additional, Camero, D, additional, Carr, C, additional, Chand, MA, additional, Charlett, A, additional, Crawford, H, additional, Cole, M, additional, Conneely, J, additional, D'Arcangelo, S, additional, Ellis, J, additional, Evans, S, additional, Foulkes, S, additional, Gillson, N, additional, Gopal, R, additional, Hall, L, additional, Hall, VJ, additional, Harrington, P, additional, Hopkins, S, additional, Hewson, J, additional, Hoschler, K, additional, Ironmonger, D, additional, Islam, J, additional, Kall, M, additional, Karagiannis, I, additional, Kay, O, additional, Khawam, J, additional, King, E, additional, Kirwan, P, additional, Kyffin, R, additional, Lackenby, A, additional, Lattimore, M, additional, Linley, E, additional, Lopez-Bernal, J, additional, Mabey, L, additional, McGregor, R, additional, Miah, S, additional, Monk, EJM, additional, Munro, K, additional, Naheed, Z, additional, Nissr, A, additional, O'Connell, AM, additional, Oguti, B, additional, Okafor, H, additional, Organ, S, additional, Osbourne, J, additional, Otter, A, additional, Patel, M, additional, Platt, S, additional, Pople, D, additional, Potts, K, additional, Ramsay, M, additional, Robotham, J, additional, Rokadiya, S, additional, Rowe, C, additional, Saei, A, additional, Sebbage, G, additional, Semper, A, additional, Shrotri, M, additional, Simmons, R, additional, Soriano, A, additional, Staves, P, additional, Taylor, S, additional, Taylor, A, additional, Tengbe, A, additional, Tonge, S, additional, Vusirikala, A, additional, Wallace, S, additional, Wellington, E, additional, Zambon, M, additional, Corrigan, D, additional, Sartaj, M, additional, Cromey, L, additional, Campbell, S, additional, Braithwaite, K, additional, Price, L, additional, Haahr, L, additional, Stewart, S, additional, Lacey, ED, additional, Partridge, L, additional, Stevens, G, additional, Ellis, Y, additional, Hodgson, H, additional, Norman, C, additional, Larru, B, additional, Mcwilliam, S, additional, Winchester, S, additional, Cieciwa, P, additional, Pai, A, additional, Loughrey, C, additional, Watt, A, additional, Adair, F, additional, Hawkins, A, additional, Grant, A, additional, Temple-Purcell, R, additional, Howard, J, additional, Slawson, N, additional, Subudhi, C, additional, Davies, S, additional, Bexley, A, additional, Penn, R, additional, Wong, N, additional, Boyd, G, additional, Rajgopal, A, additional, Arenas-Pinto, A, additional, Matthews, R, additional, Whileman, A, additional, Laugharne, R, additional, Ledger, J, additional, Barnes, T, additional, Jones, C, additional, Botes, D, additional, Chitalia, N, additional, Akhtar, S, additional, Harrison, G, additional, Horne, S, additional, Walker, N, additional, Agwuh, K, additional, Maxwell, V, additional, Graves, J, additional, Williams, S, additional, O'Kelly, A, additional, Ridley, P, additional, Cowley, A, additional, Johnstone, H, additional, Swift, P, additional, Democratis, J, additional, Meda, M, additional, Callens, C, additional, Beazer, S, additional, Hams, S, additional, Irvine, V, additional, Chandrasekaran, B, additional, Forsyth, C, additional, Radmore, J, additional, Thomas, C, additional, Brown, K, additional, Roberts, S, additional, Burns, P, additional, Gajee, K, additional, Byrne, TM, additional, Sanderson, F, additional, Knight, S, additional, Macnaughton, E, additional, Burton, BJL, additional, Smith, H, additional, Chaudhuri, R, additional, Hollinshead, K, additional, Shorten, RJ, additional, Swan, A, additional, Favager, C, additional, Murira, J, additional, Baillon, S, additional, Hamer, S, additional, Gantert, K, additional, Russell, J, additional, Brennan, D, additional, Dave, A, additional, Chawla, A, additional, Westell, F, additional, Adeboyeku, D, additional, Papineni, P, additional, Pegg, C, additional, Williams, M, additional, Ahmad, S, additional, Ingram, S, additional, Gabriel, C, additional, Pagget, K, additional, Maloney, G, additional, Ashcroft, J, additional, Del Rosario, I, additional, Crosby-Nwaobi, R, additional, Reeks, C, additional, Fowler, S, additional, Prentice, L, additional, Spears, M, additional, McKerron, G, additional, McLelland-Brooks, K, additional, Anderson, J, additional, Donaldson, S, additional, Templeton, K, additional, Coke, L, additional, Elumogo, N, additional, Elliott, J, additional, Padgett, D, additional, Mirfenderesky, M, additional, Cross, A, additional, Price, J, additional, Joyce, S, additional, Sinanovic, I, additional, Howard, M, additional, Lewis, T, additional, Cowling, P, additional, Potoczna, D, additional, Brand, S, additional, Sheridan, L, additional, Wadams, B, additional, Lloyd, A, additional, Mouland, J, additional, Giles, J, additional, Pottinger, G, additional, Coles, H, additional, Joseph, M, additional, Lee, M, additional, Orr, S, additional, Chenoweth, H, additional, Auckland, C, additional, Lear, R, additional, Mahungu, T, additional, Rodger, A, additional, Penny-Thomas, K, additional, Pai, S, additional, Zamikula, J, additional, Smith, E, additional, Stone, S, additional, Boldock, E, additional, Howcroft, D, additional, Thompson, C, additional, Aga, M, additional, Domingos, P, additional, Gormley, S, additional, Kerrison, C, additional, Marsh, L, additional, Tazzyman, S, additional, Allsop, L, additional, Ambalkar, S, additional, Beekes, M, additional, Jose, S, additional, Tomlinson, J, additional, Jones, A, additional, Price, C, additional, Pepperell, J, additional, Schultz, M, additional, Day, J, additional, Boulos, A, additional, Defever, E, additional, McCracken, D, additional, Gray, K, additional, Houston, A, additional, Planche, T, additional, Pritchard Jones, R, additional, Wycherley, Diane, additional, Bennett, S, additional, Marrs, J, additional, Nimako, K, additional, Stewart, B, additional, Kalakonda, N, additional, Khanduri, S, additional, Ashby, A, additional, Holden, M, additional, Mahabir, N, additional, Harwood, J, additional, Payne, B, additional, Court, K, additional, Staines, N, additional, Longfellow, R, additional, Green, ME, additional, Hughes, LE, additional, Halkes, M, additional, Mercer, P, additional, Roebuck, A, additional, Wilson-Davies, E, additional, Gallego, L, additional, Lazarus, R, additional, Aldridge, N, additional, Berry, L, additional, Game, F, additional, Reynolds, T, additional, Holmes, C, additional, Wiselka, M, additional, Higham, A, additional, Booth, M, additional, Duff, C, additional, Alderton, J, additional, Jory, H, additional, Virgilio, E, additional, Chin, T, additional, Qazzafi, MZ, additional, Moody, AM, additional, Tilley, R, additional, Donaghy, T, additional, Shipman, K, additional, Sierra, R, additional, Jones, N, additional, Mills, G, additional, Harvey, D, additional, Huang, YWJ, additional, Birch, J, additional, Robinson, L, additional, Board, S, additional, Broadley, A, additional, Laven, C, additional, Todd, N, additional, Eyre, DW, additional, Jeffery, K, additional, Dunachie, S, additional, Duncan, C, additional, Klenerman, P, additional, Turtle, L, additional, De Silva, T, additional, Baxendale, H, additional, and Heeney, JL, additional
Published: 2021
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11. Assessing the added value of group B Streptococcus maternal immunisation in preventing maternal infection and fetal harm: population surveillance study.

Author: Lamagni, T, Wloch, C, Broughton, K, Collin, SM, Chalker, V, Coelho, J, Ladhani, SN, Brown, CS, Shetty, N, and Johnson, AP
Subjects: STREPTOCOCCUS agalactiae, STILLBIRTH, SURGICAL site infections, CESAREAN section, IMMUNIZATION, PREGNANT women
Abstract: Objective: To assess the incidence of maternal group B Streptococcus (GBS) infection in England. Design: Population surveillance augmented through data linkage. Setting: England. Population: All pregnant women accessing the National Health Service (NHS) in England. Methods: Invasive GBS (iGBS) infections during pregnancy or within 6 weeks of childbirth were identified by linking Public Health England (PHE) national microbiology surveillance data for 2014 to NHS hospital admission records. Capsular serotypes of GBS were determined by reference laboratory typing of clinical isolates from women aged 15–44 years. Post‐caesarean section surgical site infection (SSI) caused by GBS was identified in 21 hospitals participating in PHE SSI surveillance (2009–2015). Main outcome measures: iGBS rate per 1000 maternities; risk of GBS SSI per 1000 caesarean sections. Results: Of 1601 patients diagnosed with iGBS infections in England in 2014, 185 (12%) were identified as maternal infections, a rate of 0.29 (95% CI 0.25–0.33) per 1000 maternities and representing 83% of all iGBS cases in women aged 18–44 years. Seven (3.8%) were associated with miscarriage. Fetal outcome identified excess rates of stillbirth (3.4 versus 0.5%) and extreme prematurity (<28 weeks of gestation, 3.7 versus 0.5%) compared with national averages (P < 0.001). Caesarean section surveillance in 27 860 women (21 hospitals) identified 47 cases of GBS SSI, with an estimated 4.24 (3.51–5.07) per 1000 caesarean sections, a median time‐to‐onset of 10 days (IQR 7–13 days) and ten infections that required readmission. Capsular serotype analysis identified a diverse array of strains with serotype III as the most common (43%). Conclusions: Our assessment of maternal GBS infection in England indicates the potential additional benefit of GBS vaccination in preventing adverse maternal and fetal outcomes. [ABSTRACT FROM AUTHOR]
Published: 2022
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12. Ebola Holding Units at government hospitals in Sierra Leone: evidence for a flexible and effective model for safe isolation, early treatment initiation, hospital safety and health system functioning

Author: Johnson, Oliver, Youkee, Daniel, Brown, CS, Lado, M, Wurie, A, Bash-Taqi, D, and Leather, Andrew John Moffat
Abstract: The 2014-2015 West African outbreak of Ebola Virus Disease (EVD) claimed the lives of more than 11,000 people and infected over 27,000 across seven countries. Traditional approaches to containing EVD proved inadequate and new approaches for controlling the outbreak were required. The Ministry of Health & Sanitation and King’s Sierra Leone Partnership developed a model for Ebola Holding Units (EHUs) at Government Hospitals in the capital city Freetown. The EHUs isolated screened or referred suspect patients, provided initial clinical care, undertook laboratory testing to confirm EVD status, referred onward positive cases to an Ebola Treatment Centre or negative cases to the general wards, and safely stored corpses pending collection by burial teams. Between 29th May 2014 and 19th January 2015, our five units had isolated approximately 37% (1159) of the 3097 confirmed cases within Western Urban and Rural district. Nosocomial transmission of EVD within the units appears lower than previously documented at other facilities and staff infection rates were also low. We found that EHUs are a flexible and effective model of rapid diagnosis, safe isolation and early initial treatment. We also demonstrated that it is possible for international partners and government facilities to collaborate closely during a humanitarian crisis.
Published: 2016

13. OP34 Universal antenatal culture-based screening for maternal group b streptococcus (gbs) carriage to prevent early-onset gbs disease: a systematic review for the uk national screening committee (nsc)

Author: Seedat, F, primary, Geppert, J, additional, Stinton, C, additional, Patterson, J, additional, Brown, CS, additional, Tan, B, additional, Freeman, K, additional, Uthman, OA, additional, McCarthy, ND, additional, Robinson, ER, additional, Johnson, SA, additional, Fraser, H, additional, Clarke, A, additional, and Taylor-Phillips, SA, additional
Published: 2017
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14. Management of Ebola virus disease: is environmental decontamination effective?

Author: Walker, NF, primary, Youkee, D, additional, Brown, CS, additional, Lado, M, additional, and Johnson, O, additional
Published: 2016
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15. Laboratory capability and surveillance testing for middle east respiratory syndrome coronavirus infection in the who european region, June 2013

Author: Pereyaslov, D, Rosin, P, Palm, D, Zeller, H, Gross, D, Brown, CS, Struelens, MJ, Robo, Alma, Hatibi, Iris Hasibra, Alis, Josep Casals, Sargsyan, Shushan, Gurbanov, Sadraddin, Gribkova, Natalia, Van Ranst, Marc, Ieven, Greet, Patteet, Sophie, Tomic, Stanka, Korsun, Neli, Drazenovic, Vladimir, Pieridou-Bagkatzouni, Despo, Jirincova, Helena, Havlickova, Martina, Fomsgaard, Anders, Rae, KuLli, Lappalainen, Maija, Ikonen, Niina, Lina, Bruno, Van Der Werf, Sylvie, Manuguerra, Jean-Claude, Machablishvili, Ann, Eickmann, Markus, Wolff, Thorsten, Dobler, Gerhard, Schmidt-Chanasit, Jonas, Drosten, Christian, Papa, Anna, Mentis, Andreas F, Kis, Zoltan, Löve, Arthur, Coughlan, Suzie, Mandelboim, Michal, Capobianchi, Maria R, Landini, Maria Paola, Baldanti, Fausto, Palu, Giorgio, Ghisetti, Valeria, Donatelli, Isabella, Nusupbayeva, Gaukhar, Tokhtabakiyeva, Zarina, Kasymbekova, Kaliya, Storozenko, Jelena, Erne, Sabine, Griskevicius, Algirdas, Opp, Matthias, Barbara, Christopher, Vratnica, Zoran, Reusken, Chantal, Dudman, Susanne Gjeruldsen, Hungnes, Olav, Pancer, Katarzyna, Guiomar, Raquel, Eder, Veronica, Lupulescu, Emilia, Yatsyshina, Svetlana, Pisareva, Maria, Buzitskaya, Zhanna, Sergeev, Alexander, Nedeljkovic, Jasminka, Staronova, Edita, Zupanc, Tatjana Avsic, Petrovec, Miroslav, Korva, Misa, Prosenc, Katarina, Casas, Inmaculada, Gaines, Hans, Cherpillod, Pascal, Zakirova, Niginamo, Bosevska, Golubinka, Altas, Basak, Ciblak, Meral, Mironenko, Alla, Dykhanovska, Tetiana, Demchyshyna, Iryna, Bermingham, Alison, and Rakhimov, Ravshan
Subjects: VDP::Medisinske fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806, VDP::Midical sciences: 700::Health sciences: 800::Health service and health administration research: 806
Published: 2014

16. Plant species' origin predicts dominance and response to nutrient enrichment and herbivores in global grasslands

Author: Seabloom, EW, Borer, ET, Buckley, YM, Cleland, EE, Davies, KF, Firn, J, Harpole, WS, Hautier, Y, Lind, EM, MacDougall, AS, Orrock, JL, Prober, SM, Adler, PB, Anderson, TM, Bakker, JD, Biederman, LA, Blumenthal, DM, Brown, CS, Brudvig, LA, Cadotte, M, Chu, C, Cottingham, KL, Crawley, MJ, Damschen, EI, Dantonio, CM, DeCrappeo, NM, Du, G, Fay, PA, Frater, P, Gruner, DS, Hagenah, N, Hector, A, Hillebrand, H, Hofmockel, KS, Humphries, HC, Jin, VL, Kay, A, Kirkman, KP, Klein, JA, Knops, JMH, La Pierre, KJ, Ladwig, L, Lambrinos, JG, Li, Q, Li, W, Marushia, R, McCulley, RL, Melbourne, BA, Mitchell, CE, Moore, JL, Morgan, J, Mortensen, B, O'Halloran, LR, Pyke, DA, Risch, AC, Sankaran, M, Schuetz, M, Simonsen, A, Smith, MD, Stevens, CJ, Sullivan, L, Wolkovich, E, Wragg, PD, Wright, J, Yang, L, Seabloom, EW, Borer, ET, Buckley, YM, Cleland, EE, Davies, KF, Firn, J, Harpole, WS, Hautier, Y, Lind, EM, MacDougall, AS, Orrock, JL, Prober, SM, Adler, PB, Anderson, TM, Bakker, JD, Biederman, LA, Blumenthal, DM, Brown, CS, Brudvig, LA, Cadotte, M, Chu, C, Cottingham, KL, Crawley, MJ, Damschen, EI, Dantonio, CM, DeCrappeo, NM, Du, G, Fay, PA, Frater, P, Gruner, DS, Hagenah, N, Hector, A, Hillebrand, H, Hofmockel, KS, Humphries, HC, Jin, VL, Kay, A, Kirkman, KP, Klein, JA, Knops, JMH, La Pierre, KJ, Ladwig, L, Lambrinos, JG, Li, Q, Li, W, Marushia, R, McCulley, RL, Melbourne, BA, Mitchell, CE, Moore, JL, Morgan, J, Mortensen, B, O'Halloran, LR, Pyke, DA, Risch, AC, Sankaran, M, Schuetz, M, Simonsen, A, Smith, MD, Stevens, CJ, Sullivan, L, Wolkovich, E, Wragg, PD, Wright, J, and Yang, L
Abstract: Exotic species dominate many communities; however the functional significance of species' biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant species at 64 grasslands in 13 countries, and at a subset of the sites we experimentally tested native and exotic species responses to two fundamental drivers of invasion, mineral nutrient supplies and vertebrate herbivory. Exotic species are six times more likely to dominate communities than native species. Furthermore, while experimental nutrient addition increases the cover and richness of exotic species, nutrients decrease native diversity and cover. Native and exotic species also differ in their response to vertebrate consumer exclusion. These results suggest that species origin has functional significance, and that eutrophication will lead to increased exotic dominance in grasslands.
Published: 2015

17. Gender differences and correlates of extreme dieting behaviours in US adolescents.

Author: Brown, CS, Kola-Palmer, S, Dhingra, K, Brown, CS, Kola-Palmer, S, and Dhingra, K
Abstract: This article examined correlates of and gender differences in extreme dieting behaviours among 15,425 US adolescents from the 2011 Youth Risk Behavior Survey. Suicidal thoughts and plans and binge drinking were related to extreme dieting behaviours in females, but not in males. Suicide attempts, daily smoking and marijuana use were related to extreme dieting behaviours in males, but not females. Results suggest extreme dieting behaviours are associated with a range of negative psychosocial factors and substance use behaviours, and that these differ for boys and girls. Additional research is required to elucidate these relationships, and these results provide a focus for future research, prevention and intervention efforts.
Published: 2015

18. Adolescent girls' cognitive appraisals of coping responses to sexual harassment

Author: Leaper, C, Leaper, C, Brown, CS, Ayres, MM, Leaper, C, Leaper, C, Brown, CS, and Ayres, MM
Abstract: Peer sexual harassment is a stressor for many girls in middle and high school. Prior research indicates that approach strategies (seeking support or confronting) are generally more effective than avoidance strategies in alleviating stress. However, the deployment of effective coping behaviors depends partly on how individuals evaluate different options (i.e., cognitive appraisal). The present study tested sociocultural (ethnicity, parents' education), interpersonal (perceived support from peers, mother, and father), developmental (age, perspective taking), and individual (self-esteem, feminist self-identification) factors as predictors of girls' cognitive appraisals of coping responses to sexual harassment. The sample comprised 304 girls (M age = 15.5 years, range = 14 to 18 years) from diverse socioeconomic and ethnic backgrounds who reported having previously experienced sexual harassment (e.g., unwanted sexual comments or actions). Cognitive appraisals of coping were based on the reported likelihood of confronting, seeking help, or using avoidance in response to sexual harassment. Regression analyses indicated that feminist identity, self-esteem, perspective taking, perceived support, and parents' education were variously related to appraisals of different responses. © 2013 Wiley Periodicals, Inc.
Published: 2013

19. Gender biases in early number exposure to preschool-aged children

Author: Chang, A, Chang, A, Sandhofer, CM, Brown, CS, Chang, A, Chang, A, Sandhofer, CM, and Brown, CS
Abstract: Despite dramatically narrowing gender gaps, women remain underrepresented in mathematics and math-related fields. Parents can shape expectations and interests, which may predict later differences in achievement and occupational choices. This study examines children's early mathematical environments by observing the amount that mothers talk to their sons and daughters (mean age 22 months) about cardinal number, a basic precursor to mathematics. In analyses of naturalistic mother-child interactions from the Child Language Data Exchange System (CHILDES) database, boys received significantly more number-specific language input than girls. Greater amounts of early number-related talk may promote familiarity and liking for mathematical concepts, which may influence later preferences and career choices. Additionally, the stereotype of male dominance in math may be so pervasive that culturally prescribed gender roles may be unintentionally reinforced to very young children. © 2011 SAGE Publications.
Published: 2011

20. Fit for the future? The place of global health in the UK's postgraduate medical training: a review

Author: Hall, Ja, primary, Brown, Cs, additional, Pettigrew, L, additional, Malik, Anj, additional, Watson, J, additional, Topiwala, A, additional, Mcgregor, L, additional, and Ramsay, R, additional
Published: 2013
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21. Detection of Anaplasma platys and Babesia canis vogeli and their impact on platelet numbers in free-roaming dogs associated with remote Aboriginal communities in Australia

Author: BROWN, GK, primary, CANFIELD, PJ, additional, DUNSTAN, RH, additional, ROBERTS, TK, additional, MARTIN, AR, additional, BROWN, CS, additional, and IRVING, R, additional
Published: 2006
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22. Smoke-free medical students' meetings

Author: Brown, CS, primary and Rudkjøbing, A, additional
Published: 2005
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23. Characteristics of premenopausal and postmenopausal women with acquired, generalized hypoactive sexual desire disorder: the Hypoactive Sexual Desire Disorder Registry for women.

Author: Rosen RC, Maserejian NN, Connor MK, Krychman ML, Brown CS, and Goldstein I
Published: 2012
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24. Self-management, amitriptyline, and amitripyline [sic] plus triamcinolone in the management of vulvodynia.

Author: Brown CS, Wan J, Bachmann G, and Rosen R
Abstract: OBJECTIVE: To conduct a prospective study to determine the efficacy of self-management interventions, amitriptyline, and amitriptyline plus topical triamcinolone in reducing vulvar pain in women with vulvodynia. METHODS: This was a randomized, prospective study of 53 women between the ages of 18 and 72 with vulvodynia. Participants undertook one of three treatment interventions for a period of 12 weeks: self-management, oral amitriptyline (10-20 mg/day), or topical triamcinolone plus oral amitriptyline (10-20 mg/day). The McGill Pain Questionnaire (MPQ) was used to measure changes in qualitative pain using the pain rating index (PRI) and in quantitative pain using the present pain intensity (PPI) scale. RESULTS: Of the 53 randomized subjects, 43 completed the trial. There were no statistically significant differences in PRI or PPI scores among the three treatment groups. Significant within-group differences were observed in the self-management group on the PRI and in the amitriptyline group on the PPI. CONCLUSIONS: This first randomized, prospective trial suggests that self-management has a modest effect and that low-dose amitriptyline (with and without topical triamcinolone) is not effective in reducing pain in women with vulvodynia. [ABSTRACT FROM AUTHOR]
Published: 2009
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25. Dysphagia management: an analysis of patient outcomes using VitalStim therapy compared to traditional swallow therapy.

Author: Kiger M, Brown CS, Watkins L, Kiger, Mary, Brown, Catherine S, and Watkins, Lynn
Abstract: This study compares the outcomes using VitalStim therapy to outcomes using traditional swallowing therapy for deglutition disorders. Twenty-two patients had an initial and a followup videofluoroscopic swallowing study or fiberoptic endoscopic evaluation of swallowing and were divided into an experimental group that received VitalStim treatments and a control group that received traditional swallowing therapy. Outcomes were analyzed for changes in oral and pharyngeal phase dysphagia severity, dietary consistency restrictions, and progression from nonoral to oral intake. Results of chi(2) analysis showed no statistically significant difference in outcomes between the experimental and control groups. [ABSTRACT FROM AUTHOR]
Published: 2006

26. New advances and novel treatments in heart failure.

Author: Smith AL and Brown CS
Published: 2003

27. Dietary fat and cholesterol intake in young children compared with recommended levels.

Author: Stewart KJ, Seemans CM, McFarland LD, Weinhofer JJ, and Brown CS
Published: 1999

28. Preventing complications in continuous arteriovenous hemofiltration.

Author: Whittaker AA, Brown CS, Grabenbauer KA, and Cauble L
Published: 1986

29. Accurate serodiagnosis of B19 parvovirus infections by measurement of IgG avidity.

Author: Söderlund M, Brown CS, Cohen BJ, Hedman K, Söderlund, M, Brown, C S, Cohen, B J, and Hedman, K
Abstract: In an attempt to improve diagnosis of illnesses caused by parvovirus B19 and to discriminate primary from secondary infections, a protein-denaturing assay for avidity of parvovirus-specific IgG antibodies was developed. The assay used three types of purified recombinant antigens: a fusion protein containing the unique portion of the structural protein VP1, entire capsids made up of the major structural protein VP2 alone, or VP2 plus VP1. The avidity assays were evaluated by testing sequential acute-phase serum samples from 61 well-characterized patients (34 were followed > or = 6 months), sera from 38 controls with evidence of past infection, and sera from 388 seropositive patients studied for evidence of B19 infection during an epidemic. Parvovirus capsids consisting of VP2 alone yielded unusual IgG avidity and IgG antibody responses. Three different IgG avidity assays based on VP1 protein antigens were highly sensitive and specific and were considered suitable for identification of recent primary infections by human parvovirus B19. [ABSTRACT FROM AUTHOR]
Published: 1995

30. Epitope type-specific IgG responses to capsid proteins VP1 and VP2 of human parvovirus B19.

Author: Söderlund M, Brown CS, Spaan WJ, Hedman L, Hedman K, Söderlund, M, Brown, C S, Spaan, W J, Hedman, L, and Hedman, K
Abstract: Temporal reactivities of IgG towards native and linear antigenic determinants in assembled capsids or isolated structural proteins of human parvovirus B19 were measured by an epitope type-specific IgG EIA and by immunoblots. Antigens used were baculovirus-expressed B19 capsids composed of the proteins VP1 and VP2 in their native proportion, VP2 alone, or a prokaryotic VP1 fusion protein. Follow-up sera after primary infection were compared with samples from previously infected persons. The IgG responses during acute and early convalescence phases were directed towards both conformational and linear epitopes of VP2. The antibodies against the linear VP2 epitopes disappeared abruptly within 6 months; however, the conformational VP2 antibodies persisted. The epitope type-specific IgG reactivity of VP1 was strikingly different from that of VP2. On the basis of these results, two novel tests were developed for patient diagnosis. Both tests are suitable for verifying the time of human parvovirus infection. [ABSTRACT FROM AUTHOR]
Published: 1995
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31. Safety and efficacy of weight training soon after acute myocardial infarction [corrected] [published erratum appears in J CARDIOPULM REHABIL 1998 May-Jun; 18(3): 243].

Author: Stewart KJ, McFarland LD, Weinhofer JJ, Cottrell E, Brown CS, and Shapiro EP
Published: 1998

32. Physical fitness, physical activity, and fatness in relation to blood pressure and lipids in preadolescent children.

Author: Stewart KJ, Brown CS, Hickey CM, McFarland LD, Weinhofer JJ, and Gottlieb SH
Published: 1995

33. Ratings of intelligibility of esophageal and tracheoesophageal speech

Author: Brown Cs, Blalock Pd, and Cullinan Wl
Subjects: Linguistics and Language, medicine.medical_specialty, Cognitive Neuroscience, Speech Intelligibility, Experimental and Cognitive Psychology, Audiology, Intelligibility (communication), LPN and LVN, Linguistics, Speech, Alaryngeal, Trachea, Speech and Hearing, Alaryngeal speech, Reading, medicine, Humans, Tracheoesophageal Speech, Psychology
Abstract: Audio-recorded oral reading and continuous discourse speech samples were obtained from esophageal and tracheoesophageal speakers. The samples were rated twice by each of two groups of listeners, one experienced and the other inexperienced with alaryngeal speech. The main finding was that reliable mean ratings of intelligibility of both types of speech can be obtained from experienced and from inexperienced judges. The experienced and inexperienced listeners tended to rank the speakers similarly with regard to the intelligibility of their speech samples. The reading and discourse samples also tended to be ranked similarly with regard to intelligibility. The tracheoesophageal speakers' samples as a group were rated as more intelligible than were those of the esophageal speakers.
Published: 1986

34. Hospital pathology services: rationalization versus regionalization

Author: Brown Cs
Subjects: medicine.medical_specialty, business.industry, medicine, Australia, Hospital Departments, Hospital Shared Services, Pathology, General Medicine, Pathology Department, Hospital, Intensive care medicine, business, Rationalization (economics), Surgery
Published: 1978

35. Primary cutaneous amyloidosis

Author: Brown Cs and Webster Sb
Subjects: medicine.medical_specialty, Triamcinolone acetonide, business.industry, Amyloidosis, Dermatology, General Medicine, medicine.disease, Pharmacotherapy, Primary cutaneous amyloidosis, medicine, Differential diagnosis, business, medicine.drug
Published: 1965

36. Global health in UK postgraduate medical training.

Author: Hall J, Brown CS, Pettigrew L, Malik AN, Watson J, Topiwala A, McGregor L, and Ramsay R
Published: 2012
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37. OP34 Universal antenatal culture-based screening for maternal group bstreptococcus(gbs) carriage to prevent early-onset gbs disease: a systematic review for the uk national screening committee (nsc)

Author: Seedat, F, Geppert, J, Stinton, C, Patterson, J, Brown, CS, Tan, B, Freeman, K, Uthman, OA, McCarthy, ND, Robinson, ER, Johnson, SA, Fraser, H, Clarke, A, and Taylor-Phillips, SA
Abstract: BackgroundGBS is the leading cause of morbidity and mortality from neonatal sepsis in the UK and patient groups are keen for screening to be implemented. Intrapartum antibiotic prophylaxis (IAP) is offered to women identified with GBS carriage or GBS risk factors to prevent mother to baby transmission and early-onset GBS disease (EOGBS,<7 days). This review on universal GBS screening for pregnant women was undertaken to assist NSC policy decision-making. Review questions were on: epidemiology of GBS, diagnostic accuracy of tests, effectiveness of IAP treatment, and effectiveness of universal GBS screening.MethodsMedline, Embase, and Cochrane databases were searched. Grey literature included Public Health England, British Paediatric Surveillance Unit, Audits and Confidential Enquiries, and reference lists of included papers. Participants were pregnant women≥35 weeks or neonates<7 days. The intervention was selective culture from recto-vaginal swabs at 35–37 weeks followed by IAP treatment for those who were culture positive. Reviewers independently screened records, extracted data, and assessed methodological quality using appropriate tools for each question, including QUADAS-2, Cochrane RoB, and RoBANS tools. Data were synthesised narratively.Results73 studies were included from 6287 references. EOGBS in the UK affects 0.57 per 1000 live births with a case fatality of 5.2%. Twenty-two percent of EOGBS cases and 63% of deaths are in preterm births (many would be ineligible for screening). The natural history of GBS is not known. We estimate that universal GBS screening would be offered to approximately 7 18 126 pregnant term women annually.Approximately 63 347 (57.7%) women who test positive in labour and 3282 (8%) who test negative in labour would transmit GBS to their neonates, and approximately 350 (0.5%) neonates would develop EOGBS. We estimate the positive predictive value of selective culture to detect EOGBS to be around 0.2% (350/150,806). More than 1 50 450 (>99%) women would be false positive and unnecessarily treated. Harms from IAP are unclear but will include antibiotic resistance and other possible health problems. There were no randomised controlled trials of the effectiveness of GBS screening and observational studies gave inconsistent results for EOGBS mortality and morbidity.ConclusionEOGBS is an important health condition. However, tests are not accurate predictors of maternal GBS transmission, or of EOGBS. Evidence on the harms and benefits of GBS screening is limited. Universal screening is therefore not recommended.
Published: 2017
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38. Altered value-based decision-making in anorexia nervosa: A systematic review.

Author: Brown CS, Nuñez A, and Wierenga CE
Abstract: Alterations in decision-making are considered core to anorexia nervosa (AN) phenomenology and may maintain illness through maladaptive choice behavior. This systematic review (n = 77) aimed to extend prior reviews beyond standard neuropsychological batteries by incorporating novel value-based choice tasks and computational methods. We organize findings across key factors, including: 1) illness stage, 2) developmental stage, and 3) AN subtype, and highlight available neuroimaging findings. Differences in decision-making appear consistent during illness, including in weight-restored samples, but not in recovery and not in all domains. Differences are not consistently present in adolescence, although punishment sensitivity may be heightened; AN subtypes are not consistently distinguishable. Overall, decision-making varies by context and is influenced by reward/punishment processing, risk/uncertainty, and flexibility/control. Utilization of computational modeling methods, possibly increasing precision, highlight that, although raw behavior may not differ at recovery, latent decision-making processes appear impacted. Clinical interventions may benefit from consideration of context when working to shape choice behavior and from consideration of latent decision-making processes that influence how choices are made., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Published: 2024
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39. A case of penicillin-resistant group B Streptococcus isolated from a patient in the UK.

Author: McGuire E, Ready D, Ellaby N, Potterill I, Pike R, Hopkins KL, Guy RL, Lamagni T, Mack D, Scobie A, Warren S, Brown CS, and Coelho J
Abstract: Objectives: In England, group B streptococci (GBS; Streptococcus agalactiae) are considered universally susceptible to penicillin. Reports from Africa, Asia, North America and a few European countries have described GBS isolates with penicillin MICs above the epidemiological cut-off (0.125 mg/L). Our aim was to characterize a penicillin-resistant GBS (PRGBS) isolate recovered in 2016 from a patient treated with long-term antimicrobials in the UK., Methods: Antibiotic susceptibility of a referred isolate from a discharging sinus overlying a chronic prosthetic joint infection was determined using gradient strip testing for seven antibiotics. Illumina short read sequencing was carried out using a HiSeq 2500 platform to determine MLST, capsular type, to detect mutations in the pbp genes, and to compare the isolate with contemporaneous GBS isolates circulating in the UK., Results: The GBS isolate belonged to capsular type Ia and MLST 144. We observed resistance to penicillin (MIC = 1 mg/L) and tetracycline (32 mg/L) with susceptibility to linezolid (1 mg/L), erythromycin (0.064 mg/L), clindamycin (0.064 mg/L), teicoplanin (0.064 mg/L) and vancomycin (0.25 mg/L). Deduced amino acid sequences revealed substitutions and non-synonymous changes in PBP2x and PBP2b. Genomic analysis of contemporaneous cases (n = 34) from across the UK identified single nucleotide polymorphism (SNP) variation ranged from 153-6596 SNPs., Conclusions: We confirm the first identification of a PRGBS isolate amongst referrals to the UK's national reference laboratory. Substitutions in pbp1a, pbp2a, pbp2x and pbp2b were identified that likely developed in the face of long-term beta-lactam antibiotic use., (© The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.)
Published: 2024
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40. Ultrasound-guided trigeminal nerve approach at the level of the pterygopalatine fossa in cat cadavers.

Author: Fernandez Barrientos MA, Cenani A, Brown CS, Arzi B, Wolfs E, and Pypendop BH
Subjects: Animals, Cats anatomy & histology, Ultrasonography, Interventional veterinary, Ultrasonography, Interventional methods, Prospective Studies, Pterygopalatine Fossa anatomy & histology, Cadaver, Trigeminal Nerve anatomy & histology, Trigeminal Nerve diagnostic imaging, Nerve Block veterinary, Nerve Block methods
Abstract: Objective: To describe an ultrasound-guided suprazygomatic approach to the trigeminal nerve block in cat cadavers., Study Design: Prospective descriptive study., Animals: Ten feline cadaver heads., Methods: A 25:75 methylene blue-iopamidol mixture (0.1 mL cm -1 cranium length) was injected into 10 cadaver heads using an ultrasound-guided suprazygomatic approach. A computed tomography (CT) scan was performed to identify contrast presence at the orbital fissure, foramen rotundum and ovale, followed by anatomical dissection to identify staining of the pterygopalatine fossa (PPF), extraconal retrobulbar area, mandibular and maxillary nerves. Descriptive statistics were used to summarize results., Results: A total of 20 injections were performed. Of these, 1/20 misinjection occurred and excluded from further reporting. The volume of injectate was 0.9 (0.9-1.1) mL [median (range)]. Staining of the PPF, extraconal space, maxillary and mandibular nerves over more than 6 mm was achieved in 19/19 (100%), 18/19 (95%), 17/19 (89%) and 19/19 (100%) of injections, respectively. CT showed presence of contrast within 5 mm of the orbital fissure, foramen rotundum and ovale in 18/19 (95%), 19/19 (100%) and 19/19 (100%) of the injections, respectively. No intracranial migration was observed., Conclusions and Clinical Relevance: This cadaver study illustrates that the suprazygomatic ultrasound-guided trigeminal nerve injection technique can successfully stain the PPF, retrobulbar cone extraconally, mandibular and maxillary nerves. Consequently, this technique has the potential to be used in vivo in cats to desensitize areas innervated by the trigeminal nerve., (Copyright © 2024 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.)
Published: 2024
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41. Protection of vaccine boosters and prior infection against mild/asymptomatic and moderate COVID-19 infection in the UK SIREN healthcare worker cohort: October 2023 to March 2024.

Author: Kirwan PD, Foulkes S, Munro K, Sparkes D, Singh J, Henry A, Dunne A, Timeyin J, Russell S, Khawam J, Blick D, Otter AD, Hettiarachchi N, Cairns MD, Jackson CH, Seaman S, Brown CS, Atti A, Islam J, Charlett A, De Angelis D, Presanis AM, Hall VJ, and Hopkins S
Subjects: Humans, Male, Female, United Kingdom epidemiology, Adult, Middle Aged, Cohort Studies, Vaccination, Asymptomatic Infections, COVID-19 prevention & control, COVID-19 immunology, Health Personnel statistics & numerical data, COVID-19 Vaccines immunology, COVID-19 Vaccines administration & dosage, SARS-CoV-2 immunology, SARS-CoV-2 genetics, Immunization, Secondary, Vaccine Efficacy
Abstract: Objectives: Bivalent original/BA.4-5 and monovalent XBB.1.5 mRNA boosters were offered to UK healthcare workers (HCWs) in the autumn of 2023. We aimed to estimate booster vaccine effectiveness (VE) and post-infection immunity among the SIREN HCW cohort over the subsequent 6-month period of XBB.1.5 and JN.1 variant circulation., Methods: Between October 2023 to March 2024, 2867 SIREN study participants tested fortnightly for SARS-CoV-2 and completed symptoms questionnaires. We used multi-state models, adjusted for vaccination, prior infection, and demographic covariates, to estimate protection against mild/asymptomatic and moderate SARS-CoV-2 infection., Results: Half of the participants (1422) received a booster during October 2023 (280 bivalent, 1142 monovalent), and 536 (19%) had a PCR-confirmed infection over the study period. Bivalent booster VE was 15.1% (-55.4 to 53.6%) at 0-2 months and 4.2% (-46.4 to 37.3%) at 2-4 months post-vaccination. Monovalent booster VE was 44.2% (95% CI 21.7 to 60.3%) at 0-2 months, and 24.1% (-0.7 to 42.9%) at 2-4 months. VE was greater against moderate infection than against mild/asymptomatic infection, but neither booster showed evidence of protection after 4 months. Controlling for vaccination, compared to an infection >2 years prior, infection within the past 6 months was associated with 58.6% (30.3 to 75.4%) increased protection against moderate infection and 38.5% (5.8 to 59.8%) increased protection against mild/asymptomatic infection., Conclusions: Monovalent XBB.1.5 boosters provided short-term protection against SARS-CoV-2 infection, particularly against moderate symptoms. Vaccine formulations that target the circulating variant may be suitable for inclusion in seasonal vaccination campaigns among HCWs., Competing Interests: Declaration of Competing Interest All authors have completed the ICJME uniform disclosure form at: https://www.icmje.org/disclosure-of-interest/ and declare: CSB and SH report grant funding from the NIHR HPRU; CSB reports participation in an ad-hoc one-off market research advisory on a variety of infection topics; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work., (Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.)
Published: 2024
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42. High- versus low-dose ketamine for analgesia in older adults in the emergency department.

Author: Ginsburg AD, Heaton HA, Beaudrie-Nunn A, E Silva LOJ, Canterbury E, Brown CS, Palmer AK, Cole KC, Wieruszewski ED, and Bellolio F
Abstract: Background and Objectives: Ketamine is increasingly being utilized in the management of acute pain in the emergency department (ED), including for older adults, a population at increased risk of adverse effects from medications. We aimed to compare the safety and analgesic effects of high-dose (≥0.3mg/kg) to low-dose (<0.3mg/kg) intravenous (IV) ketamine among older ED patients., Methods: Multi-center, retrospective cohort study of adults ≥60years who received IV ketamine for pain between 2018 and 2021. The primary outcome was pain improvement as measured by the Numerical Rating Scale (NRS) pain score within 60min after administration. Secondary outcomes included adverse effects (early discontinuation, nausea, rescue benzodiazepines and intubation) and the need for rescue analgesia. Linear regression was used to assess the association between the change in NRS pain scores and dose after adjusting for baseline pain, requiring an additional dose of ketamine, and receiving an opioid., Results: A total of 130 older adults received ketamine as an analgesic (37 high-dose, 93 low-dose). Median age was 69.2years, 52 % were women, 40 % had a history of substance use disorder. Prior to ketamine, 76 % received alternate analgesics and 23 % antiemetics. Baseline mean pain score was lower in the high-dose group (6.7 vs. 8.3, difference -1.7 [95 % CI -2.6 to -0.7], p = 0.013). Change in NRS pain scores were similar between the high-dose and low-dose groups (-2.4 [95 % CI -3.6 to -1.3] vs -1.6 [95 % CI -2.2 to -0.9], p = 0.27). After adjustment for baseline pain score, the high-dose group had a larger reduction in pain scores (-1.3 [95 % CI -2.6 to -0.1], p = 0.042) and percent change of pain (-23.8 % [95 % CI -42.1 % to -5.4 %], p = 0.012). There was no significant difference in rates of rescue analgesia (35.1 % vs. 44.1 %, p = 0.35) or early discontinuation (29.7 % vs. 32.3 %, p = 0.78). Rates of adverse effects were similar., Conclusion: High-dose and low-dose ketamine reduced pain scores in older adults. High-dose ketamine led to a greater reduction in pain scores, and there was no observed difference in adverse effects or the need for rescue analgesia. One-third needed discontinuation of ketamine in both groups., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier Inc. All rights reserved.)
Published: 2024
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43. Propofol, Triglycerides, and Acute Pancreatitis: A Multi-Center Epidemiologic Analysis.

Author: Heybati K, Deng J, Xie G, Poudel K, Zhou F, Rizwan Z, Brown CS, Acker CT, Gajic O, and Yadav H
Abstract: Rationale: Propofol is one of the first-line sedative-hypnotic agents for critically ill adults requiring mechanical ventilation. While propofol can elevate triglyceride levels, and the latter is a risk factor for pancreatitis, the association between propofol and acute pancreatitis is unclear., Objectives: To determine the clinical impact and potential associations between propofol infusion, hypertriglyceridemia and acute pancreatitis., Methods: This is an observational multicenter study of adults (≥18 years old) admitted to an intensive care unit. requiring mechanical ventilation and receiving continuous propofol infusion for at least 24 hours. The primary outcomes were the frequency of hypertriglyceridemia and acute pancreatitis. Further analyses were done to determine the clinical impact of elevated triglyceride levels (i.e. sedation changes) and risk factors for pancreatitis development., Measurements and Main Results: Of 11,828 patients included, 33.2% (N=3922) had triglyceride levels measured, of whom 21.7% (N=851) had hypertriglyceridemia at 4.5 (SD 6.8) days after propofol initiation. Of those still requiring sedation, 70.4% (N=576/818) received alternative sedatives following hypertriglyceridemia. Pancreatitis occurred in 1.2% (N=47/3922) and was more frequent in those with hypertriglyceridemia (3.2%, 27/851 versus 0.7%, 20/3071; P<0.001). Following adjustment for potential confounding variables, each 100 mg/dL increase in triglyceride levels was associated with an 11% increase in risk of pancreatitis. Propofol dose was not associated with pancreatitis development., Conclusions: Acute pancreatitis is uncommon in patients receiving propofol infusion, and occurs over a wide range of triglyceride levels, indicating a multifactorial pathophysiology. Hypertriglyceridemia frequently prompts the use of alternative sedatives. Further study is needed to determine how to best monitor and treat hypertriglyceridemia in critically ill patients receiving propofol infusion.
Published: 2024
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44. Protecting healthcare and patient pathways from infection and antimicrobial resistance.

Author: Cocker D, Fitzgerald R, Brown CS, and Holmes A
Subjects: Humans, Cross Infection prevention & control, Drug Resistance, Bacterial, Drug Resistance, Microbial, Infection Control methods, Critical Pathways, Antimicrobial Stewardship, Anti-Bacterial Agents therapeutic use
Abstract: Competing Interests: Competing interests: We have read and understood BMJ policy on declaration of interests and have no conflicts of interest to declare. Provenance and peer review: Commissioned; externally peer reviewed.
Published: 2024
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45. Disparities in pain management among transgender patients presenting to the emergency department for abdominal pain.

Author: Engstrom K, Bellolio F, Jeffery MM, Sutherland SC, Carpenter KP, Jackson G, Cole K, Chedid V, Davidge-Pitts CJ, Sunga KL, Gonzalez C, and Brown CS
Abstract: Objective: Transgender and gender-diverse (TGD) individuals have a gender identity or expression that differs from the sex assigned to them at birth. They are an underserved population who experience health care inequities. Our primary objective was to identify if there are treatment differences between TGD and cisgender lesbian/gay/bisexual/queer (LGBQ) or heterosexual individuals presenting with abdominal pain to the emergency department (ED)., Methods: Retrospective observational cohort study of patients ≥12 years of age presenting to 21 EDs within a health care system with a chief complaint of abdominal pain between 2018 and 2022. TGD patients were matched 1:1:1:1 to cisgender LGBQ women and men and cisgender heterosexual women and men, respectively. Propensity score matching covariates included age, ED site, mental health history, and gastrointestinal history. The primary outcome was pain assessment within 60 min of arrival. The secondary outcome was analgesics administered in the ED., Results: We identified 300 TGD patients, of whom 300 TGD patients were successfully matched for a total cohort of 1300 patients. The median (IQR) age was 25 (20-32) years and most patients were treated in a community ED (58.2%). There was no difference between groups in pain assessment within 60 min of arrival (59.0% TGD vs. 63.2% non TGD, p = 0.19). There were no differences in the number of times pain was assessed (median [IQR] 2 [1-3] vs. 2 [1-4], p = 0.31) or the severity of pain between groups (5.5 [4-7] vs. 6 [4-7], p = 0.11). TGD patients were more likely to receive nonsteroidal anti-inflammatory drugs (32.0% vs. 24.9%, p = 0.015) and less likely to receive opioids than non-TGD patients (24.7% vs. 36.9%, p = <0.001). TGD and nonbinary patients, along with LGBQ cisgender women (24.7%) and heterosexual cisgender women (34%), were less likely to receive opioids than LGBQ cisgender men (54%) and heterosexual cisgender men (42.3%, p < 0.01)., Conclusion: There was no difference in frequency of pain assessment, regardless of gender identity or sexual orientation. More cisgender men, compared to TGD and cisgender women, received opioids for their pain., (© 2024 Society for Academic Emergency Medicine.)
Published: 2024
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46. Prevalence and impact of persistent symptoms following SARS-CoV-2 infection among healthcare workers: A cross-sectional survey in the SIREN cohort.

Author: Foulkes S, Evans J, Neill C, Bishop J, Khawam J, Islam J, Atti A, Brown CS, Hopkins S, Price L, and Hall V
Subjects: Humans, Cross-Sectional Studies, Male, Female, Prevalence, Middle Aged, Adult, United Kingdom epidemiology, Surveys and Questionnaires, Cohort Studies, Vaccination statistics & numerical data, COVID-19 Vaccines administration & dosage, COVID-19 epidemiology, Health Personnel statistics & numerical data, SARS-CoV-2
Abstract: Introduction: Following SARS-CoV-2 infection, some patients experience a range of long-lasting symptoms, with a specific burden on their lives and ability to work., Aim: We describe the prevalence and impact of persistent symptoms pre-/post-vaccination in SIREN study participants., Methods: A cross-sectional study of SARS-CoV-2 positive participants was carried out within SIREN, a frequently tested UK healthcare worker cohort with vaccination and demographic data available. Participants with a SARS-CoV-2 positive PCR or anti-SARS-CoV-2 sample between 01 March 2020 and 31 September 2022 were asked via a questionnaire about symptoms and days absent from work following infection. Responses were excluded if infection dates were inconsistent with study records or missing key data. Symptom type/duration and whether infection occurred pre-/post-vaccination and during which variant period were described. Logistic regression was used to estimate factors associated with persistent symptoms (>12 weeks), adjusting for vaccination and demographic factors. The median days absent from work were also determined., Results: Of 16,599 invitations, 6677 participants responded, and 5053 were included in the analysis. The prevalence of persistent symptoms (symptoms lasting over 12 weeks) differed by infection episode; highest for first infections (32.7%; 1557/4767) compared to second (21.6%; 214/991) and third infections (21.6%; 16/74). Most frequently reported symptoms were fatigue, tiredness, shortness of breath and difficulty concentrating. A higher prevalence of persistent symptoms was reported during the Wild-type variant period compared to the other variant periods (52.9% Wild-type vs. 20.7% Omicron, for any symptom reported during their first infection). Overall, persistent symptoms were higher among unvaccinated participants (unvaccinated 38.1% vs vaccinated 22.0%). Multivariable analysis showed that participants were less likely to report persistent symptoms in infections occurring after vaccination compared to those with an infection before vaccination in the Alpha/Delta and Omicron periods (Alpha/Delta: adjusted Odds Ratio (aOR) 0.66, CI 95% 0.51-0.87, p = aOR 0.07, CI 95% 0.01-0.65, p = 0.02). About half of participants reported that their persistent symptoms impacted their day-to-day (51.8%) and work-related (42.1%) activities 'a little', and 24.0% and 14.4% reported that the impact was 'A lot'. 8.9% reported they had reduced their working hours, and 13.9% had changed their working pattern., Discussion: Persistent symptoms were frequent in our cohort, and there was a reduction in symptom duration in those with multiple infection episodes during later variant periods and post-vaccination. The impact of persistent symptoms resulting in reducing working hours or adjusting working patterns has important implications for workforce resilience. UK healthcare workers were highly exposed during the pandemic, demonstrating a significant burden., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.)
Published: 2024
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47. Solving the Rubik's Cube of AAA mortality in Brazil using space-time cube analysis.

Author: Brown CS, Rocha OM, and Obi AT
Subjects: Humans, Brazil epidemiology, Time Factors, Spatio-Temporal Analysis, Risk Factors, Risk Assessment, Male, Female, Aortic Aneurysm, Abdominal mortality, Aortic Aneurysm, Abdominal surgery
Abstract: Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Published: 2024
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48. Local adaptation to climate facilitates a global invasion.

Author: Gamba D, Vahsen ML, Maxwell TM, Pirtel N, Romero S, Ee JJV, Penn A, Das A, Ben-Zeev R, Baughman O, Blaney CS, Bodkins R, Budha-Magar S, Copeland SM, Davis-Foust SL, Diamond A, Donnelly RC, Dunwiddie PW, Ensing DJ, Everest TA, Hoitink H, Holdrege MC, Hufbauer RA, Juzėnas S, Kalwij JM, Kashirina E, Kim S, Klisz M, Klyueva A, Langeveld M, Lutfy S, Martin D, Merkord CL, Morgan JW, Nagy DU, Ott JP, Puchalka R, Pyle LA, Rasran L, Rector BG, Rosche C, Sadykova M, Shriver RK, Stanislavschi A, Starzomski BM, Stone RL, Turner KG, Urza AK, VanWallendael A, Wegenschimmel CA, Zweck J, Brown CS, Leger EA, Blumenthal DM, Germino MJ, Porensky LM, Hooten MB, Adler PB, and Lasky JR
Abstract: Local adaptation may facilitate range expansion during invasions, but the mechanisms promoting destructive invasions remain unclear. Cheatgrass ( Bromus tectorum ), native to Eurasia and Africa, has invaded globally, with particularly severe impacts in western North America. We sequenced 307 genotypes and conducted controlled experiments. We found that diverse lineages invaded North America, where long-distance gene flow is common. Ancestry and phenotypic clines in the native range predicted those in the invaded range, indicating pre-adapted genotypes colonized different regions. Common gardens showed directional selection on flowering time that reversed between warm and cold sites, potentially maintaining clines. In the Great Basin, genomic predictions of strong local adaptation identified sites where cheatgrass is most dominant. Preventing new introductions that may fuel adaptation is critical for managing ongoing invasions., Competing Interests: Competing interests: Authors declare that they have no competing interests.
Published: 2024
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49. To combat antimicrobial resistance, invest in test-to-treat strategies.

Author: McKendry RA, Rogers E, Singer M, and Brown CS
Subjects: Humans, Decision Support Systems, Clinical, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial, Drug Prescriptions standards
Published: 2024
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50. Influence of Obesity on the Relationship of Cardiometabolic Risks Factors With Cardiovascular Disease in Older African and European Americans.

Author: Moore-Harrison T, Keane K, Brandon LJ, Smith G, and Brown CS
Subjects: Aged, Female, Humans, Male, Middle Aged, Blood Pressure, Body Mass Index, Glycated Hemoglobin analysis, Lipids blood, Risk Factors, United States epidemiology, Black or African American, Cardiometabolic Risk Factors, Cardiovascular Diseases epidemiology, Obesity epidemiology, White
Abstract: Purpose: This study evaluated the impact of obesity on cardiometabolic risk factors (CRF) interrelationships and predictive efficiency of CVD development in older African (AA) and European Americans (EA)., Design: A comparative research design evaluated CRF risk profile differences between participant groups., Setting: Seven neighborhoods in a southern US city., Subjects: A sample of 179 older AA (n = 128) and EA (n = 51) adults., Measures: Non-fasting blood samples were evaluated for lipids and lipoproteins, glycosylated hemoglobin, systolic -(SBP) and diastolic blood pressure (DBP), body mass index (BMI), body fat percentage (BF%) and physical function., Analysis: Data were analysis with descriptive statistics, t-tests, and correlations., Results: AA were heavier than EA although all had above average age-appropriate fitness. Means and relationships between CRF and other variables were different ( P < .05) based on race. Both AA (41.3 + 5.8) and EA (38.6 + 6.4) BF% were CRF risks. Holding BMI constant, CRF were generally not related, and the relationships were different for AA and EA. AA had a range of 13.0 to 27.2% more favorable values for cholesterol, HDL-C, and triglyceride. EA had favorable A1c (EA 5.8 vs AA 6.2%) values., Conclusions: A limitation of this report is the small sample size. Although further research is warranted, these findings suggest population specific CRF selections would improve CVD prediction in AA., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Published: 2024
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