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1. Space Telescope and Optical Reverberation Mapping Project. XII. Broad-Line Region Modeling of NGC 5548

Author

Williams, P. R., Pancoast, A., Treu, T., Brewer, B. J., Peterson, B. M., Barth, A. J., Malkan, M. A., De Rosa, G., Horne, Keith, Kriss, G. A., Arav, N., Bentz, M. C., Cackett, E. M., Bontà, E. Dalla, Dehghanian, M., Done, C., Ferland, G. J., Grier, C. J., Kaastra, J., Kara, E., Kochanek, C. S., Mathur, S., Mehdipour, M., Pogge, R. W., Proga, D., Vestergaard, M., Waters, T., Adams, S. M., Anderson, M. D., Arévalo, P., Beatty, T. G., Bennert, V. N., Bigley, A., Bisogni, S., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brotherton, M., Brown, J. E., Brown, J. S., Canalizo, G., Carini, M. T., Clubb, K. I., Comerford, J. M., Corsini, E. M., Crenshaw, D. M., Croft, S., Croxall, K. V., Deason, A. J., De Lorenzo-Cáceres, A., Denney, K. D., Dietrich, M., Edelson, R., Efimova, N. V., Ely, J., Evans, P. A., Fausnaugh, M. M., Filippenko, A. V., Flatland, K., Fox, O. D., Gardner, E., Gates, E. L., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Greene, J. E., Grupe, D., Gupta, A., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Hutchison, T., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Jones, J., Kaspi, S., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S., Kim, S. C., King, A., Klimanov, S. A., Knigge, C., Krongold, Y., Lau, M. W., Lee, J. C., Leonard, D. C., Li, Miao, Lira, P., Lochhaas, C., Ma, Zhiyuan, Manne-Nicholas, E. R., MacInnis, F., Mauerhan, J. C., McGurk, R., Hardy, I. M. Mc, Montuori, C., Morelli, L., Mosquera, A., Mudd, D., Müller-Sánchez, F., Nazarov, S. V., Norris, R. P., Nousek, J. A., Nguyen, M. L., Ochner, P., Okhmat, D. N., Papadakis, I., Parks, J. R., Pei, L., Penny, M. T., Pizzella, A., Poleski, R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Scott, B., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Sung, H. -I., Tayar, J., Tejos, N., Turner, C. S., Uttley, P., Van Saders, J., Vaughan, S. A., Vican, L., Villanueva Jr., S., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Yuk, H., Zheng, W., Zhu, W., and Zu, Y.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present geometric and dynamical modeling of the broad line region for the multi-wavelength reverberation mapping campaign focused on NGC 5548 in 2014. The dataset includes photometric and spectroscopic monitoring in the optical and ultraviolet, covering the H$\beta$, C IV, and Ly$\alpha$ broad emission lines. We find an extended disk-like H$\beta$ BLR with a mixture of near-circular and outflowing gas trajectories, while the C IV and Ly$\alpha$ BLRs are much less extended and resemble shell-like structures. There is clear radial structure in the BLR, with C IV and Ly$\alpha$ emission arising at smaller radii than the H$\beta$ emission. Using the three lines, we make three independent black hole mass measurements, all of which are consistent. Combining these results gives a joint inference of $\log_{10}(M_{\rm BH}/M_\odot) = 7.64^{+0.21}_{-0.18}$. We examine the effect of using the $V$ band instead of the UV continuum light curve on the results and find a size difference that is consistent with the measured UV-optical time lag, but the other structural and kinematic parameters remain unchanged, suggesting that the $V$ band is a suitable proxy for the ionizing continuum when exploring the BLR structure and kinematics. Finally, we compare the H$\beta$ results to similar models of data obtained in 2008 when the AGN was at a lower luminosity state. We find that the size of the emitting region increased during this time period, but the geometry and black hole mass remain unchanged, which confirms that the BLR kinematics suitably gauge the gravitational field of the central black hole., Comment: 26 pages, 19 figures, 1 table, accepted for publication in ApJ

Published
2020
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2. Space Telescope and Optical Reverberation Mapping Project. IX. Velocity-Delay Maps for Broad Emission Lines in NGC 5548

Author

Horne, Keith, De Rosa, G., Peterson, B. M., Barth, A. J., Ely, J., Fausnaugh, M. M., Kriss, G. A., Pei, L., Adams, S. M., Anderson, M. D., Arevalo, P., Beatty, T G., Bennert, V. N., Bentz, M. C., Bigley, A., Bisogni, S., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brotherton, M., Brown, J. E., Brown, J. S., Cackett, E. M., Canalizo, G., Carini, M. T., Clubb, K. I., Comerford, J. M., Corsini, E. M., Crenshaw, D. M., Croft, S., Croxall, K. V., Bonta, E. Dalla, Deason, A. J., Dehghanian, M., De Lorenzo-Caceres, A., Denney, K. D., Dietrich, M., Done, C., Edelson, R., Efimova, N. V., Eracleous, M., Evans, P. A., Ferland, G. J., Filippenko, A. V., Flatland, K., Fox, O. D., Gardner, E., Gates, E. L., Gehrels, N., Geier, S., Gelbord, J. M., Goad, M. R., Gonzalez, L., Gorjian, V., Greene, J. E., Grier, C. J., Grupe, D., Gupta, A., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Hutchison, T., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S., Kim, S. C., King, A., Klimanov, S. A., Kochanek, C. S., Korista, K. T., Krongold, Y., Lau, M. W., Lee, J. C., Leonard, D. C., Li, Miao, Lira, P., Lochhaas, C., Ma, Zhiyuan, MacInnis, F., Malkan, M. A., Manne-Nicholas, E. R., Mathur, S., Mauerhan, J. C., McGurk, R., Hardy, I. M. Mc, Montuori, C., Morelli, L., Mosquera, A., Mudd, D., Mueller-Sanchez, F., Nazarov, S. V., Netzer, H., Norris, R. P., Nousek, J. A., Nguyen, M. L., Ochner, P., Okhmat, D. N., Pancoast, A., Papadakis, I., Parks, J. R., Penny, M. T., Pizzella, A., Pogge, R. W., Poleski, R., Pott, J. -U., Proga, D., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Schnuelle, K., Scott, B., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Strauss, M. A., Sung, H. -I., Tayar, J., Teems, K. G., Tejos, N., Treu, T., Turner, C. S., Uttley, P., Van Saders, J ., Vestergaard, M., Vican, L., Villanueva Jr, S., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Yuk, H., Zakamska, N. L., Zheng, W., Zhu, W., and Zu, Y.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We report velocity-delay maps for prominent broad emission lines, Ly_alpha, CIV, HeII and H_beta, in the spectrum of NGC5548. The emission-line responses inhabit the interior of a virial envelope. The velocity-delay maps reveal stratified ionization structure. The HeII response inside 5-10 light-days has a broad single-peaked velocity profile. The Ly_alpha, CIV, and H_beta responses peak inside 10 light-days, extend outside 20 light-days, and exhibit a velocity profile with two peaks separated by 5000 km/s in the 10 to 20 light-day delay range. The velocity-delay maps show that the M-shaped lag vs velocity structure found in previous cross-correlation analysis is the signature of a Keplerian disk with a well-defined outer edge at R=20 light-days. The outer wings of the M arise from the virial envelope, and the U-shaped interior of the M is the lower half of an ellipse in the velocity-delay plane. The far-side response is weaker than that from the near side, so that we see clearly the lower half, but only faintly the upper half, of the velocity--delay ellipse. The delay tau=(R/c)(1-sin(i))=5 light-days at line center is from the near edge of the inclined ring, giving the inclination i=45 deg. A black hole mass of M=7x10^7 Msun is consistent with the velocity-delay structure. A barber-pole pattern with stripes moving from red to blue across the CIV and possibly Ly_alpha line profiles suggests the presence of azimuthal structure rotating around the far side of the broad-line region and may be the signature of precession or orbital motion of structures in the inner disk. Further HST observations of NGC 5548 over a multi-year timespan but with a cadence of perhaps 10 days rather than 1 day could help to clarify the nature of this new AGN phenomenon., Comment: 19 pages, 9 figures, ApJ in press

Published
2020
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3. Space Telescope and Optical Reverberation Mapping Project. VIII. Time Variability of Emission and Absorption in NGC 5548 Based on Modeling the Ultraviolet Spectrum

Author

Kriss, G. A., De Rosa, G., Ely, J., Peterson, B. M., Kaastra, J., Mehdipour, M., Ferland, G. J., Dehghanian, M., Mathur, S., Edelson, R., Korista, K. T., Arav, N., Barth, A. J., Bentz, M. C., Brandt, W. N., Crenshaw, D. M., Bontà, E. Dalla, Denney, K. D., Done, C., Eracleous, M., Fausnaugh, M. M., Gardner, E., Goad, M. R., Grier, C. J., Horne, Keith, Kochanek, C. S., Mchardy, I. M., Netzer, H., Pancoast, A., Pei, L., Pogge, R. W., Proga, D., Silva, C., Tejos, N., Vestergaard, M., Adams, S. M., Anderson, M. D., Arévalo, P., Beatty, T G., Behar, E., Bennert, V. N., Bianchi, S., Bigley, A., Bisogni, S., Boissay-Malaquin, R., Borman, G. A., Bottorff, M. C., Breeveld, A. A., Brotherton, M., Brown, J. E., Brown, J. S., Cackett, E. M., Canalizo, G., Cappi, M., Carini, M. T., Clubb, K. I., Comerford, J. M., Coker, C. T., Corsini, E. M., Costantini, E., Croft, S., Croxall, K. V., Deason, A. J., De Lorenzo-Cáceres, A., De Marco, B., Dietrich, M., Di Gesu, L., Ebrero, J., Evans, P. A., Filippenko, A. V., Flatland, K., Gates, E. L., Gehrels, N., Geier, Z S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Grupe, D., Gupta, A., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Hutchison, T. A., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Kaspi, S., Kelly, B. C., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S. C., Kim, S. Y., King, A., Klimanov, S. A., Krongold, Y., Lau, M. W., Lee, J. C., Leonard, D. C., Li, Miao, Lira, P., Lochhaas, C., Ma, Zhiyuan, Macinnis, F., Malkan, M. A., Manne-Nicholas, E. R., Matt, G., Mauerhan, J. C., Mcgurk, R., Montuori, C., Morelli, L., Mosquera, A., Mudd, D., Müller-Sánchez, F., Nazarov, S. V., Norris, R. P., Nousek, J. A., Nguyen, M. L., Ochner, P., Okhmat, D. N., Paltani, S., Parks, J. R., Pinto, C., Pizzella, A., Poleski, R., Ponti, G., Pott, J. -U., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Schnülle, K., Scott, B., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Sung, H. -I., Tayar, J., Teems, K. G., Treu, T., Turner, C. S., Uttley, P., Van Saders, J ., Vican, L., Villforth, C., Villanueva Jr., S., Walton, D. J., Waters, T., Weiss, Y., Woo, J. -H., Yan, H., Yuk, H., Zheng, W., Zhu, W., and Zu, Y.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We model the ultraviolet spectra of the Seyfert 1 galaxy NGC~5548 obtained with the Hubble Space Telescope during the 6-month reverberation-mapping campaign in 2014. Our model of the emission from NGC 5548 corrects for overlying absorption and deblends the individual emission lines. Using the modeled spectra, we measure the response to continuum variations for the deblended and absorption-corrected individual broad emission lines, the velocity-dependent profiles of Ly$\alpha$ and C IV, and the narrow and broad intrinsic absorption features. We find that the time lags for the corrected emission lines are comparable to those for the original data. The velocity-binned lag profiles of Ly$\alpha$ and C IV have a double-peaked structure indicative of a truncated Keplerian disk. The narrow absorption lines show delayed response to continuum variations corresponding to recombination in gas with a density of $\sim 10^5~\rm cm^{-3}$. The high-ionization narrow absorption lines decorrelate from continuum variations during the same period as the broad emission lines. Analyzing the response of these absorption lines during this period shows that the ionizing flux is diminished in strength relative to the far-ultraviolet continuum. The broad absorption lines associated with the X-ray obscurer decrease in strength during this same time interval. The appearance of X-ray obscuration in $\sim\,2012$ corresponds with an increase in the luminosity of NGC 5548 following an extended low state. We suggest that the obscurer is a disk wind triggered by the brightening of NGC 5548 following the decrease in size of the broad-line region during the preceding low-luminosity state., Comment: 50 pages, 30 figures, uses aastex62.cls. Accepted for publication in ApJ, 07/06/2019. High-level products page in MAST will go live after 7/15/2019. Replaced Figure 4 on 7/12/2019 to be more red/green color-blind friendly

Published
2019
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4. Velocity-resolved reverberation mapping of five bright Seyfert 1 galaxies

Author

De Rosa, G., Fausnaugh, M. M., Grier, C. J., Peterson, B. M., Denney, K. D., Horne, Keith, Bentz, M. C., Ciroi, S., Bonta`, E. Dalla, Joner, M. D., Kaspi, S., Kochanek, C. S., Pogge, R. W., Sergeev, S. G., Vestergaard, M., Adams, S. M., Antognini, J., Salvo, C. Araya, Armstrong, E., Bae, J., Barth, A. J., Beatty, T. G., Bhattacharjee, A., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brown, J. E., Brown, J. S., Brotherton, M. S., Coker, C. T., Clanton, C., Cracco, V., Crawford, S. M., Croxall, K. V., Eftekharzadeh, S., Eracleous, M., Fiorenza, S. L., Frassati, A., Hawkins, K., Henderson, C. B., Holoien, T. W. -S., Hutchison, T., Kellar, J., Kilerci-Eser, E., Kim, S., King, A. L., La Mura, G., Laney, C. D., Li, M., Lochhaas, C., Ma, Z., MacInnis, F., Manne-Nicholas, E. R., Mason, M., McGraw, S. M., Mogren, K., Montouri, C., Moody, J. W., Mosquera, A. M., Mudd, D., Musso, R., Nazarov, S. V., Nguyen, M. L., Ochner, P., Okhmat, D. N., Onken, C. A., Ou-Yang, B., Pancoast, A., Pei, L., Penny, M., Poleski, R., Portaluri, E., Prieto, J. -L., Price-Whelan, A. M., Pulatova, N. G., Rafter, S., Roettenbacher, R. M., Romero-Colmenero, E., Runnoe, J., Schimoia, J. S., Shappee, B. J., Sherf, N., Simonian, G. V., Siviero, A., Skowron, D. M., Skowron, J., Somers, G., Spencer, M., Starkey, D. A., Stevens, D. J., Stoll, R., Tamajo, E., Tayar, J., van Saders, J. L., Valenti, S., Villanueva, Jr., S., Villforth, C., Weiss, Y., Winkler, H., Zastrow, J., Zhu, W., and Zu, Y.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present the first results from a reverberation-mapping campaign undertaken during the first half of 2012, with additional data on one AGN (NGC 3227) from a 2014 campaign. Our main goals are (1) to determine the black hole masses from continuum-Hbeta reverberation signatures, and (2) to look for velocity-dependent time delays that might be indicators of the gross kinematics of the broad-line region. We successfully measure Hbeta time delays and black hole masses for five AGNs, four of which have previous reverberation mass measurements. The values measured here are in agreement with earlier estimates, though there is some intrinsic scatter beyond the formal measurement errors. We observe velocity dependent Hbeta lags in each case, and find that the patterns have changed in the intervening five years for three AGNs that were also observed in 2007., Comment: Accepted for publication on ApJ; 32 pages, 16 figures, 10 tables

Published
2018
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6. Space Telescope and Optical Reverberation Mapping Project. VII. Understanding the UV anomaly in NGC 5548 with X-Ray Spectroscopy

Author

Mathur, S., Gupta, A., Page, K., Pogge, R. W., Krongold, Y., Goad, M. R., Adams, S. M., Anderson, M. D., Arevalo, P., Barth, A. J., Bazhaw, C., Beatty, T. G., Bentz, M. C., Bigley, A., Bisogni, S., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brown, J. E., Brown, J. S., Cackett, E. M., Canalizo, G., Carini, M. T., Clubb, K. I., Comerford, J. M., Coker, C. T., Corsini, E. M., Crenshaw, D. M., Croft, S., Croxall, K. V., Bonta, E. Dalla, Deason, A. J., Denney, K. D., De Lorenzo-Caceres, A., De Rosa, G., Dietrich, M., Edelson, R., Ely, J., Eracleous, M., Evans, P. A., Fausnaugh, M. M., Ferland, G. J., Filippenko, A. V., Flatland, K., Fox, O. D., Gates, E. L., Gehrels, N., Geier, S., Gelbord, J. M., Gorjian, V., Greene, J. E., Grier, C. J., Grupe, D., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Horenstein, D., Horne, Keith, Hutchison, T., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, B. C., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S., Kim, S. C., King, A., Klimanov, S. A., Kochanek, C. S., Korista, K. T., Kriss, G. A., Lau, M. W., Lee, J. C., Leonard, D. C., Li, M., Lira, P., Ma, Z., MacInnis, F., Manne-Nicholas, E. R., Malkan, M. A., Mauerhan, J. C., McGurk, R., McHardy, I. M., Montouri, C., Morelli, L., Mosquera, A., Mudd, D., Muller-Sanchez, F., Musso, R., Nazarov, S. V., Netzer, H., Nguyen, M. L., Norris, R. P., Nousek, J. A., Ochner, P., Okhmat, D. N., Ou-Yang, B., Pancoast, A., Papadakis, I., Parks, J. R., Pei, L., Peterson, B. M., Pizzella, A., Poleski, R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Schnülle, K., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Sung, H. -I., Tayar, J., Tejos, N., Turner, C. S., Uttley, P., Van Saders, J., Vestergaard, M., Vican, L., VillanuevaJr., S., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Yuk, H., Zheng, W., Zhu, W., and Zu, Y.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

During the Space Telescope and Optical Reverberation Mapping Project (STORM) observations of NGC 5548, the continuum and emission-line variability became de-correlated during the second half of the 6-month long observing campaign. Here we present Swift and Chandra X-ray spectra of NGC 5548 obtained as a part of the campaign. The Swift spectra show that excess flux (relative to a power-law continuum) in the soft X-ray band appears before the start of the anomalous emission-line behavior, peaks during the period of the anomaly, and then declines. This is a model-independent result suggesting that the soft excess is related to the anomaly. We divide the Swift data into on- and off-anomaly spectra to characterize the soft excess via spectral fitting. The cause of the spectral differences is likely due to a change in the intrinsic spectrum rather than being due to variable obscuration or partial covering. The Chandra spectra have lower signal-to-noise ratios, but are consistent with Swift data. Our preferred model of the soft excess is emission from an optically thick, warm Comptonizing corona, the effective optical depth of which increases during the anomaly. This model simultaneously explains all the three observations: the UV emission line flux decrease, the soft-excess increase, and the emission line anomaly., Comment: ApJ in press. Replaced with the accepted version

Published
2017
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16. Angiogenesis, Metabolism, Endothelial and Platelet Markers in Diabetes and Cardiovascular Disease

Author

Blann, A. D., Brown, J. E., Heitmar, R., Blann, A. D., Brown, J. E., and Heitmar, R.

Abstract

Introduction: Diabetes is a leading risk factor for cardiovascular disease (CVD), the pathophysiology of both being linked to metabolic, endothelial, renal, angiogenic and platelet abnormalities. We hypothesised that abnormalities in these systems are more adverse in those whose CVD is compounded by diabetes, compared to those with diabetes or CVD alone. Materials and methods: Serum or plasma from 66 patients with diabetes alone, 76 with CVD alone, and 70 with both diabetes and CVD i.e. diabetic cardiovascular disease, was probed for markers of angiogenesis [angiopoietin 1 and 2, vascular endothelial growth factor (VEGF) and endoglin], metabolic [soluble receptor for advanced glycation products (sRAGE), leptin, lipocalin-2, interleukin-8, and cystatin-C], the endothelium (von Willebrand factor, endothelial microparticles and soluble E selectin)], and the platelet (platelet microparticles and soluble P selectin) by ELISA, Luminex or flow cytometry. Results: VEGF (p = 0.04), von Willebrand factor (p = 0.001) and endothelial microparticles (p = 0.042) were all higher in diabetic cardiovascular disease than in diabetes alone and cardiovascular disease alone. Soluble E selectin was higher in diabetic cardiovascular disease than in diabetes alone (p = 0.045), whilst cystatin-C (p = 0.004) and soluble P selectin (p < 0.001) were higher in diabetes and diabetic cardiovascular disease than in cardiovascular disease alone. There were no differences in angiopoietin 1 or 2, endoglin, sRAGE, leptin, lipocalin-2, or interleukin-8. Conclusion: Angiopoietin 1 or 2, endoglin, sRAGE, leptin, lipocalin-2, interleukin-8, and cystatin-c cannot differentiate diabetes from cardiovascular disease, or both conditions combined. Our data point to a more adverse endothelial (von Willebrand factor, endothelial microparticles), and angiogenic profile (VEGF) in those with diabetic cardiovascular disease, supporting the view that this group should be targeted more aggressively.

Published
2022

18. Immunodiagnosis and Immunotherapy of Tetanus and Botulinum Neurotoxins

Author

Middlebrook, J. L., Brown, J. E., Capron, A., editor, Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConnel, I., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, and Montecucco, Cesare, editor

Published
1995
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24. Silicon-Film™ Product I: Initial Production Performance

Author

Barnett, A. M., Bottenberg, W. R., Bragagnolo, J. A., Brooks, D. S., Checchi, J. C., Kendall, C. L., Lasswell, P. G., Brown, J. E., Mulligan, W. P., Rand, J. A., Hall, R. B., Luque, A., editor, Sala, G., editor, Palz, W., editor, Dos Santos, G., editor, and Helm, P., editor

Published
1991
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30. An updated strategic research agenda for the integration of radioecology in the european radiation protection research

Author

Gilbin, R., (0000-0003-2775-3494) Arnold, T., Beresford, N. A., Berthomieu, C., Brown, J. E., With, G., Horemans, N., Madruga, M. J., Masson, O., Merroun, M., Michalik, B., Muikku, M., O’Toole, S., Mrdakovic Popic, J., Nogueira, P., Real, A., (0000-0001-9097-9299) Sachs, S., Salbu, B., Stark, K., Steiner, M., Sweek, L., Vandenhove, H., Vidal, M., Vives I. Batlle, J., Gilbin, R., (0000-0003-2775-3494) Arnold, T., Beresford, N. A., Berthomieu, C., Brown, J. E., With, G., Horemans, N., Madruga, M. J., Masson, O., Merroun, M., Michalik, B., Muikku, M., O’Toole, S., Mrdakovic Popic, J., Nogueira, P., Real, A., (0000-0001-9097-9299) Sachs, S., Salbu, B., Stark, K., Steiner, M., Sweek, L., Vandenhove, H., Vidal, M., and Vives I. Batlle, J.

Abstract

The ALLIANCE Strategic Research Agenda (SRA) for radioecology is a living document that defines a long-term vision (20 years) of the needs for, and implementation of, research in radioecology in Europe. The initial SRA, published in 2012, included consultation with a wide range of stakeholders (Hinton et al., 2013). This revised version is an update of the research strategy for identified research challenges, and includes a strategy to maintain and develop the associated required capacities for workforce (education and training) and research infrastructures and capabilities. Beyond radioecology, this SRA update constitutes a contribution to the implementation of a Joint Roadmap for radiation protection research in Europe (CONCERT, 2019a). This roadmap, established under the H2020 European Joint Programme CONCERT, provides a common and shared vision for radiation protection research, priority areas and strategic objectives for collaboration within a European radiation protection research programme to 2030 and beyond. Considering the advances made since the first SRA, this updated version presents research challenges and priorities including identified scientific issues that, when successfully resolved, have the potential to impact substantially and strengthen the system and/or practice of the overall radiation protection (game changers) in radioecology with regard to their integration into the global vision of European research in radiation protection. An additional aim of this paper is to encourage contribution from research communities, end users, decision makers and other stakeholders in the evaluation, further advancement and accomplishment of the identified priorities.

Published
2021

31. Space Telescope and Optical Reverberation Mapping Project. IX. Velocity-Delay Maps for Broad Emission Lines in NGC 5548

Author

Horne, Keith, Rosa, G. De, Peterson, B. M., Barth, A. J., Ely, J., Fausnaugh, M. M., Kriss, G. A., Pei, L., Bentz, M. C., Cackett, E. M., Edelson, R., Eracleous, M., Goad, M. R., Grier, C. J., Kaastra, J., Kochanek, C. S., Krongold, Y., Mathur, S., Netzer, H., Proga, D., Tejos, N., Vestergaard, M., Villforth, C., Adams, S. M., Anderson, M. D., Arevalo, P., Beatty, T. G., Bennert, V. N., Bigley, A., Bisogni, S., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brotherton, M., Brown, J. E., Brown, J. S., Canalizo, G., Carini, M. T., Clubb, K. I., Comerford, J. M., Corsini, E. M., Crenshaw, D. M., Croft, S., Croxall, K. V., Bonta, E. Dalla, Deason, A. J., Dehghanian, M., Lorenzo-Caceres, A. De, Denney, K. D., Dietrich, M., Done, C., Efimova, N. V., Evans, P. A., Ferland, G. J., Filippenko, A. V., Flatland, K., Fox, O. D., Gardner, E., Gates, E. L., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Greene, J. E., Grupe, D., Gupta, A., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Hutchison, T., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Jones, J., Kaspi, S., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S., Kim, S. C., King, A., Klimanov, S. A., Korista, K. T., Lau, M. W., Lee, J. C., Leonard, D. C., Li, Miao, Lira, P., Lochhaas, C., Ma, Zhiyuan, MacInnis, F., Malkan, M. A., Manne-Nicholas, E. R., Mauerhan, J. C., McGurk, R., McHardy, I. M., Montuori, C., Morelli, L., Mosquera, A., Mudd, D., Muller-Sanchez, F., Nazarov, S. V., Norris, R. P., Nousek, J. A., Nguyen, M. L., Ochner, P., Okhmat, D. N., Pancoast, A., Papadakis, I., Parks, J. R., Penny, M. T., Pizzella, A., Pogge, R. W., Poleski, R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Schnuelle, K., Scott, B., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Sung, H. -I., Tayar, J., Treu, T., Turner, C. S., Uttley, P., Van Saders, J., Vican, L., Villanueva, S., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Yuk, H., Zheng, W., Zhu, W., Zu, Y., Horne, Keith, Rosa, G. De, Peterson, B. M., Barth, A. J., Ely, J., Fausnaugh, M. M., Kriss, G. A., Pei, L., Bentz, M. C., Cackett, E. M., Edelson, R., Eracleous, M., Goad, M. R., Grier, C. J., Kaastra, J., Kochanek, C. S., Krongold, Y., Mathur, S., Netzer, H., Proga, D., Tejos, N., Vestergaard, M., Villforth, C., Adams, S. M., Anderson, M. D., Arevalo, P., Beatty, T. G., Bennert, V. N., Bigley, A., Bisogni, S., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brotherton, M., Brown, J. E., Brown, J. S., Canalizo, G., Carini, M. T., Clubb, K. I., Comerford, J. M., Corsini, E. M., Crenshaw, D. M., Croft, S., Croxall, K. V., Bonta, E. Dalla, Deason, A. J., Dehghanian, M., Lorenzo-Caceres, A. De, Denney, K. D., Dietrich, M., Done, C., Efimova, N. V., Evans, P. A., Ferland, G. J., Filippenko, A. V., Flatland, K., Fox, O. D., Gardner, E., Gates, E. L., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Greene, J. E., Grupe, D., Gupta, A., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Hutchison, T., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Jones, J., Kaspi, S., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S., Kim, S. C., King, A., Klimanov, S. A., Korista, K. T., Lau, M. W., Lee, J. C., Leonard, D. C., Li, Miao, Lira, P., Lochhaas, C., Ma, Zhiyuan, MacInnis, F., Malkan, M. A., Manne-Nicholas, E. R., Mauerhan, J. C., McGurk, R., McHardy, I. M., Montuori, C., Morelli, L., Mosquera, A., Mudd, D., Muller-Sanchez, F., Nazarov, S. V., Norris, R. P., Nousek, J. A., Nguyen, M. L., Ochner, P., Okhmat, D. N., Pancoast, A., Papadakis, I., Parks, J. R., Penny, M. T., Pizzella, A., Pogge, R. W., Poleski, R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Schnuelle, K., Scott, B., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Sung, H. -I., Tayar, J., Treu, T., Turner, C. S., Uttley, P., Van Saders, J., Vican, L., Villanueva, S., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Yuk, H., Zheng, W., Zhu, W., and Zu, Y.

Abstract

In this contribution, we achieve the primary goal of the active galactic nucleus (AGN) STORM campaign by recovering velocity-delay maps for the prominent broad emission lines (Ly alpha, C IV, He II, and H beta) in the spectrum of NGC 5548. These are the most detailed velocity-delay maps ever obtained for an AGN, providing unprecedented information on the geometry, ionization structure, and kinematics of the broad-line region. Virial envelopes enclosing the emission-line responses show that the reverberating gas is bound to the black hole. A stratified ionization structure is evident. The He ii response inside 5-10 lt-day has a broad single-peaked velocity profile. The Ly alpha, C IV, and H beta responses extend from inside 2 to outside 20 lt-day, with double peaks at 2500 km s(-1) in the 10-20 lt-day delay range. An incomplete ellipse in the velocity-delay plane is evident in H beta. We interpret the maps in terms of a Keplerian disk with a well-defined outer rim at R = 20 lt-day. The far-side response is weaker than that from the near side. The line-center delay tau = (R/c)(1 - sin i) approximate to 5 days gives the inclination i approximate to 45 degrees. The inferred black hole mass is (BH) 7 x 10(7) M-circle dot. In addition to reverberations, the fit residuals confirm that emission-line fluxes are depressed during the "BLR Holiday" identified in previous work. Moreover, a helical "Barber-Pole" pattern, with stripes moving from red to blue across the C IV and Ly alpha line profiles, suggests azimuthal structure rotating with a 2 yr period that may represent precession or orbital motion of inner-disk structures casting shadows on the emission-line region farther out.

Published
2021

39. Space Telescope and Optical Reverberation Mapping Project. IX. Velocity–Delay Maps for Broad Emission Lines in NGC 5548

Author

Horne, Keith, primary, Rosa, G. De, additional, Peterson, B. M., additional, Barth, A. J., additional, Ely, J., additional, Fausnaugh, M. M., additional, Kriss, G. A., additional, Pei, L., additional, Bentz, M. C., additional, Cackett, E. M., additional, Edelson, R., additional, Eracleous, M., additional, Goad, M. R., additional, Grier, C. J., additional, Kaastra, J., additional, Kochanek, C. S., additional, Krongold, Y., additional, Mathur, S., additional, Netzer, H., additional, Proga, D., additional, Tejos, N., additional, Vestergaard, M., additional, Villforth, C., additional, Adams, S. M., additional, Anderson, M. D., additional, Arévalo, P., additional, Beatty, T G., additional, Bennert, V. N., additional, Bigley, A., additional, Bisogni, S., additional, Borman, G. A., additional, Boroson, T. A., additional, Bottorff, M. C., additional, Brandt, W. N., additional, Breeveld, A. A., additional, Brotherton, M., additional, Brown, J. E., additional, Brown, J. S., additional, Canalizo, G., additional, Carini, M. T., additional, Clubb, K. I., additional, Comerford, J. M., additional, Corsini, E. M., additional, Crenshaw, D. M., additional, Croft, S., additional, Croxall, K. V., additional, Bontà, E. Dalla, additional, Deason, A. J., additional, Dehghanian, M., additional, Lorenzo-Cáceres, A. De, additional, Denney, K. D., additional, Dietrich, M., additional, Done, C., additional, Efimova, N. V., additional, Evans, P. A., additional, Ferland, G. J., additional, Filippenko, A. V., additional, Flatland, K., additional, Fox, O. D., additional, Gardner, E., additional, Gates, E. L., additional, Gehrels, N., additional, Geier, S., additional, Gelbord, J. M., additional, Gonzalez, L., additional, Gorjian, V., additional, Greene, J. E., additional, Grupe, D., additional, Gupta, A., additional, Hall, P. B., additional, Henderson, C. B., additional, Hicks, S., additional, Holmbeck, E., additional, Holoien, T. W.-S., additional, Hutchison, T., additional, Im, M., additional, Jensen, J. J., additional, Johnson, C. A., additional, Joner, M. D., additional, Jones, J., additional, Kaspi, S., additional, Kelly, P. L., additional, Kennea, J. A., additional, Kim, M., additional, Kim, S., additional, Kim, S. C., additional, King, A., additional, Klimanov, S. A., additional, Korista, K. T., additional, Lau, M. W., additional, Lee, J. C., additional, Leonard, D. C., additional, Li, Miao, additional, Lira, P., additional, Lochhaas, C., additional, Ma, Zhiyuan, additional, MacInnis, F., additional, Malkan, M. A., additional, Manne-Nicholas, E. R., additional, Mauerhan, J. C., additional, McGurk, R., additional, McHardy, I. M., additional, Montuori, C., additional, Morelli, L., additional, Mosquera, A., additional, Mudd, D., additional, Müller–Sánchez, F., additional, Nazarov, S. V., additional, Norris, R. P., additional, Nousek, J. A., additional, Nguyen, M. L., additional, Ochner, P., additional, Okhmat, D. N., additional, Pancoast, A., additional, Papadakis, I., additional, Parks, J. R., additional, Penny, M. T., additional, Pizzella, A., additional, Pogge, R. W., additional, Poleski, R., additional, Pott, J.-U., additional, Rafter, S. E., additional, Rix, H.-W., additional, Runnoe, J., additional, Saylor, D. A., additional, Schimoia, J. S., additional, Schnülle, K., additional, Scott, B., additional, Sergeev, S. G., additional, Shappee, B. J., additional, Shivvers, I., additional, Siegel, M., additional, Simonian, G. V., additional, Siviero, A., additional, Skielboe, A., additional, Somers, G., additional, Spencer, M., additional, Starkey, D., additional, Stevens, D. J., additional, Sung, H.-I., additional, Tayar, J., additional, Treu, T., additional, Turner, C. S., additional, Uttley, P., additional, Van Saders, J., additional, Vican, L., additional, Villanueva, S., additional, Weiss, Y., additional, Woo, J.-H., additional, Yan, H., additional, Young, S., additional, Yuk, H., additional, Zheng, W., additional, Zhu, W., additional, and Zu, Y., additional

Published
2021
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47. Space Telescope and Optical Reverberation Mapping Project. XII. Broad-line Region Modeling of NGC 5548

Author

Williams, P. R., primary, Pancoast, A., additional, Treu, T., additional, Brewer, B. J., additional, Peterson, B. M., additional, Barth, A. J., additional, Malkan, M. A., additional, Rosa, G. De, additional, Horne, Keith, additional, Kriss, G. A., additional, Arav, N., additional, Bentz, M. C., additional, Cackett, E. M., additional, Bontà, E. Dalla, additional, Dehghanian, M., additional, Done, C., additional, Ferland, G. J., additional, Grier, C. J., additional, Kaastra, J., additional, Kara, E., additional, Kochanek, C. S., additional, Mathur, S., additional, Mehdipour, M., additional, Pogge, R. W., additional, Proga, D., additional, Vestergaard, M., additional, Waters, T., additional, Adams, S. M., additional, Anderson, M. D., additional, Arévalo, P., additional, Beatty, T. G., additional, Bennert, V. N., additional, Bigley, A., additional, Bisogni, S., additional, Borman, G. A., additional, Boroson, T. A., additional, Bottorff, M. C., additional, Brandt, W. N., additional, Breeveld, A. A., additional, Brotherton, M., additional, Brown, J. E., additional, Brown, J. S., additional, Canalizo, G., additional, Carini, M. T., additional, Clubb, K. I., additional, Comerford, J. M., additional, Corsini, E. M., additional, Crenshaw, D. M., additional, Croft, S., additional, Croxall, K. V., additional, Deason, A. J., additional, Lorenzo-Cáceres, A. De, additional, Denney, K. D., additional, Dietrich, M., additional, Edelson, R., additional, Efimova, N. V., additional, Ely, J., additional, Evans, P. A., additional, Fausnaugh, M. M., additional, Filippenko, A. V., additional, Flatland, K., additional, Fox, O. D., additional, Gardner, E., additional, Gates, E. L., additional, Gehrels, N., additional, Geier, S., additional, Gelbord, J. M., additional, Gonzalez, L., additional, Gorjian, V., additional, Greene, J. E., additional, Grupe, D., additional, Gupta, A., additional, Hall, P. B., additional, Henderson, C. B., additional, Hicks, S., additional, Holmbeck, E., additional, Holoien, T. W.-S., additional, Hutchison, T., additional, Im, M., additional, Jensen, J. J., additional, Johnson, C. A., additional, Joner, M. D., additional, Jones, J., additional, Kaspi, S., additional, Kelly, P. L., additional, Kennea, J. A., additional, Kim, M., additional, Kim, S., additional, Kim, S. C., additional, King, A., additional, Klimanov, S. A., additional, Knigge, C., additional, Krongold, Y., additional, Lau, M. W., additional, Lee, J. C., additional, Leonard, D. C., additional, Li, Miao, additional, Lira, P., additional, Lochhaas, C., additional, Ma, Zhiyuan, additional, MacInnis, F., additional, Manne-Nicholas, E. R., additional, Mauerhan, J. C., additional, McGurk, R., additional, McHardy, I. M., additional, Montuori, C., additional, Morelli, L., additional, Mosquera, A., additional, Mudd, D., additional, Müller–Sánchez, F., additional, Nazarov, S. V., additional, Norris, R. P., additional, Nousek, J. A., additional, Nguyen, M. L., additional, Ochner, P., additional, Okhmat, D. N., additional, Papadakis, I., additional, Parks, J. R., additional, Pei, L., additional, Penny, M. T., additional, Pizzella, A., additional, Poleski, R., additional, Pott, J.-U., additional, Rafter, S. E., additional, Rix, H.-W., additional, Runnoe, J., additional, Saylor, D. A., additional, Schimoia, J. S., additional, Scott, B., additional, Sergeev, S. G., additional, Shappee, B. J., additional, Shivvers, I., additional, Siegel, M., additional, Simonian, G. V., additional, Siviero, A., additional, Skielboe, A., additional, Somers, G., additional, Spencer, M., additional, Starkey, D., additional, Stevens, D. J., additional, Sung, H.-I., additional, Tayar, J., additional, Tejos, N., additional, Turner, C. S., additional, Uttley, P., additional, Van Saders, J ., additional, Vaughan, S. A., additional, Vican, L., additional, Villanueva, S., additional, Villforth, C., additional, Weiss, Y., additional, Woo, J.-H., additional, Yan, H., additional, Young, S., additional, Yuk, H., additional, Zheng, W., additional, Zhu, W., additional, and Zu, Y., additional

Published
2020
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48. Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors

Author

Mulryan, K., Gitterman, D. P., Lewis, C. J., Vial, C., Leckie, B. J., Cobb, A. L., Brown, J. E., Conley, E. C., Buell, G., Pritchard, C. A., and Evans, R. J.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): K. Mulryan [1]; D. P. Gitterman [1]; C. J. Lewis [1]; C. Vial [1]; B. J. Leckie [2]; A. L. Cobb [3]; J. E. Brown [3]; E. C. Conley [...]

Published
2000
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50. Anti-neoplastic effect of epigallocatechin gallate on breast cancer cells through glucose metabolism

Author

Al-shaeli, S J, Ethaeb, A M, and Brown, J E

Subjects
food and beverages
Abstract

Breast cancer (BC) is the primary cause of women cancer death, which could be prevented by EGCG that has been recently shown several health properties included anti-cancer, however the mechanism underpinning still poorly understood. In this study, several biological activities of both MCF7 and MDA-MB-231 cells were evaluated in response to EGCG. Cell viability and the role of Akt and AMPK inhibitor molecules, and sodium pyruvate on this viability, apoptosis, metastasis, and interestingly regulation of glucose metabolism were assessed. EGCG promoted cytotoxicity in both BC cell lines after 24h but not less. Co-incubated cells with Akt and AMPK inhibitors alongside EGCG significantly caused more reduction in cell viability compared to the effect of EGCG alone with maximum effect referred to Akt inhibitor. While supplemented sodium pyruvate significantly restored the decreases in cell viability. Remarkably, EGCG induced apoptosis through increased caspase 3/7 activation associated with upregulated Bax gene, in addition to anti-metastatic effect through decreasing cellular migration. Importantly, lactate production was sharply reduced after 6h (no alteration of viable cells) and 24h (decreased viable cells) concomitant with significant blocked glucose uptake in response to EGCG. In conclusion, EGCG could be a potential anti-migration, the anti-cancerous therapeutic agent through targeting cancer cells glucose metabolism.

Published
2019

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