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1. Quantifying uncertainty in analysis of shockless dynamic compression experiments on platinum. II. Bayesian model calibration.

Author

Brown, Justin L., Davis, Jean-Paul, Tucker, J. Derek, Huerta, Gabriel, and Shuler, Kurtis W.

Subjects
*PLATINUM, *CALIBRATION, *LOW temperatures
Abstract

Dynamic shockless compression experiments provide the ability to explore material behavior at extreme pressures but relatively low temperatures. Typically, the data from these types of experiments are interpreted through an analytic method called Lagrangian analysis. In this work, alternative analysis methods are explored using modern statistical methods. Specifically, Bayesian model calibration is applied to a new set of platinum data shocklessly compressed to 570 GPa. Several platinum equation-of-state models are evaluated, including traditional parametric forms as well as a novel non-parametric model concept. The results are compared to those in Paper I obtained by inverse Lagrangian analysis. The comparisons suggest that Bayesian calibration is not only a viable framework for precise quantification of the compression path, but also reveals insights pertaining to trade-offs surrounding model form selection, sensitivities of the relevant experimental uncertainties, and assumptions and limitations within Lagrangian analysis. The non-parametric model method, in particular, is found to give precise unbiased results and is expected to be useful over a wide range of applications. The calibration results in estimates of the platinum principal isentrope over the full range of experimental pressures to a standard error of 1.6%, which extends the results from Paper I while maintaining the high precision required for the platinum pressure standard. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Quantifying uncertainty in analysis of shockless dynamic compression experiments on platinum. I. Inverse Lagrangian analysis.

Author

Davis, Jean-Paul and Brown, Justin L.

Subjects
*PLATINUM, *YIELD stress, *MONTE Carlo method, *STRESS-strain curves, *DIAMOND anvil cell
Abstract

Absolute measurements of solid-material compressibility by magnetically driven shockless dynamic compression experiments to multi-megabar pressures have the potential to greatly improve the accuracy and precision of pressure calibration standards for use in diamond anvil cell experiments. To this end, we apply characteristics-based inverse Lagrangian analysis (ILA) to 11 sets of ramp-compression data on pure platinum (Pt) metal and then reduce the resulting weighted-mean stress–strain curve to the principal isentrope and room-temperature isotherm using simple models for yield stress and Grüneisen parameter. We introduce several improvements to methods for ILA and quasi-isentrope reduction, the latter including calculation of corrections in wave speed instead of stress and pressure to render results largely independent of initial yield stress while enforcing thermodynamic consistency near zero pressure. More importantly, we quantify in detail the propagation of experimental uncertainty through ILA and model uncertainty through quasi-isentrope reduction, considering all potential sources of error except the electrode and window material models used in ILA. Compared to previous approaches, we find larger uncertainty in longitudinal stress. Monte Carlo analysis demonstrates that uncertainty in the yield-stress model constitutes by far the largest contribution to uncertainty in quasi-isentrope reduction corrections. We present a new room-temperature isotherm for Pt up to 444 GPa, with 1-sigma uncertainty at that pressure of just under ± 1.2 % ; the latter is about a factor of three smaller than uncertainty previously reported for multi-megabar ramp-compression experiments on Pt. The result is well represented by a Vinet-form compression curve with (isothermal) bulk modulus K 0 = 270.3 ± 3.8 GPa, pressure derivative K 0 ′ = 5.66 ± 0.10 , and correlation coefficient R K 0 , K 0 ′ = − 0.843. [ABSTRACT FROM AUTHOR]

Published
2023
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3. A broad study of tantalum strength from ambient to extreme conditions

Author

Prime, Michael B., Arsenlis, Athanasios, Austin, Ryan A., Barton, Nathan R., Battaile, Corbett C., Brown, Justin L., Burakovsky, Leonid, Buttler, William T., Chen, Shuh-Rong, Dattelbaum, Dana M., Fensin, Saryu J., Flicker, Dawn G., Gray, George T., III, Greeff, Carl, Jones, David R., Lane, J. Matthew D, Lim, Hojun, Luscher, D.J., Mattsson, Thomas R., McNaney, James M., Park, Hye-Sook, Powell, Philip D., Prisbrey, Shon T., Remington, Bruce A., Rudd, Robert E., Sjue, Sky K., and Swift, Damian C.

Published
2022
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6. Quasi-isentropic compression of an additively manufactured aluminum alloy to 14.8 GPa.

Author

Brown, Nathan P., Specht, Paul E., and Brown, Justin L.

Subjects
ALUMINUM alloys, MODULUS of rigidity, SHEAR strength, ANISOTROPY, ALLOYS, STRAIN rate
Abstract

We uniaxially and shocklessly compressed an additively manufactured aluminum alloy, laser powder bed fusion (LPBF) AlSi10Mg, to peak stresses ranging from 4.4 to 14.8 GPa at peak strain rates on the order of 10 6 s − 1 via a series of magnetic loading experiments to measure the principal isentrope, yield strength, and shear modulus as a function of material orientation and applied stress. We did not observe significant anisotropy in any of the measured quantities. We found that the principal isentrope, within the uncertainty and up to our peak stress, overlaps the material's Hugoniot. We measured yield strengths and shear moduli ranging from 0.28 to 0.81 GPa and 36 to 52 GPa, respectively. Our results indicate that LPBF AlSi10Mg behaves similarly to wrought Al alloys under quasi-isentropic compression. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Girth‐based administered activity for pediatric 99mTc‐DMSA SPECT.

Author

Li, Ye, Brown, Justin L., Xu, Jingyan, Chen, Junyu, Ghaly, Michael, Dugan, Monet, Cao, Xinhua, Du, Yong, Fahey, Frederic H., Bolch, Wesley, Sgouros, George, and Frey, Eric C.

Subjects
*KIDNEY cortex, *WAIST circumference, *TASK performance, *RECEIVER operating characteristic curves, *KIDNEY physiology
Abstract

Background: Pediatric molecular imaging requires a balance between administering an activity that will yield sufficient diagnostic image quality while maintaining patient radiation exposure at acceptable levels. In current clinical practice, this balance is arrived at by the current North American Consensus Guidelines in which patient weight is used to recommend the administered activity (AA). Purpose: We have previously demonstrated that girth (waist circumference at the level of the kidneys) is better at equalizing image quality than patient weight for pediatric Tc‐99m DMSA renal function imaging. However, the correlation between image quality (IQ), AA, and patient girth has not been rigorously and systematically developed. In this work, we generate a series of curves showing the tradeoff between AA and IQ as a function of patient girth, providing the data for standards bodies to develop the next generation of dosing guideline for pediatric DMSA SPECT. Methods: An anthropomorphic phantom series that included variations in age (5, 10, and 15 years), gender (M, F), local body morphometry (5, 10, 50, 90, and 95th girth percentiles), and kidney size (±15% standard size), was used to generate realistic SPECT projections. A fixed and clinically challenging defect‐to‐organ volume percentage (0.49% of renal cortex value) was used to model a focal defect with zero uptake (i.e., full local loss of renal function). Task‐based IQ assessment methods were used to rigorously measure IQ in terms of renal perfusion defect detectability. This assessment was performed at multiple count levels (corresponding to various AAs) for groups of patients that had similar girths and defect sizes. Receiver‐operating characteristics (ROC) analysis was applied; the area under the ROC curve (AUC) was used as a figure‐of‐merit for task performance. Curves showing the tradeoff between AUC and AA were generated for these groups of phantoms. Results: Overall, the girth‐based dosing method suggested different amounts of AA compared to weight‐based dosing for the phantoms that had a relatively large body weight but a small girth or phantoms with relatively small bodyweight but large girth. Reductions of AA to 62.9% compared to weight‐based dosing guidelines can potentially be realized while maintaining a baseline (AUC = 0.80) IQ for certain 15‐year‐olds who have a relatively small girth and large defect size. Note that the task‐based IQ results are heavily dependent on the simulated defect size for the defect detection task and the appropriate AUC value must be decided by the physicians for this diagnostic task. These results are based purely on simulation and are subject to future clinical validation. Conclusions: The study provides simulation‐based IQ‐AA data for a girth‐based dosing method for pediatric renal SPECT, suggesting that patient waist circumference at the level of kidneys should be considered in selecting the AA needed to achieve an acceptable IQ. This data may be useful for standards bodies to develop girth‐based dosing guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Renal 99mTc-DMSA pharmacokinetics in pediatric patients

Author

Plyku, Donika, Ghaly, Michael, Li, Ye, Brown, Justin L., O’Reilly, Shannon, Khamwan, Kitiwat, Goodkind, Alison B., Sexton-Stallone, Briana, Cao, Xinhua, Zurakowski, David, Fahey, Frederic H., Treves, S. Ted, Bolch, Wesley E., Frey, Eric C., and Sgouros, George

Published
2021
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16. Girth‐based administered activity for pediatric 99mTc‐DMSA SPECT

Author

Li, Ye, primary, Brown, Justin L., additional, Xu, Jingyan, additional, Chen, Junyu, additional, Ghaly, Michael, additional, Dugan, Monet, additional, Cao, Xinhua, additional, Du, Yong, additional, Fahey, Frederic H., additional, Bolch, Wesley, additional, Sgouros, George, additional, and Frey, Eric C., additional

Published
2023
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21. List of Contributors

Author

Acharya, Abhinav, primary, Ackun-Farmmer, Marian A., additional, Aggas, John R., additional, Andersen, Phillip J., additional, Anderson, James M., additional, Anseth, Kristi, additional, Archer, Paul A., additional, Ashammakhi, Nureddin, additional, Avila, Jose D., additional, Babensee, Julia E., additional, Badylak, Stephen f., additional, Baek, Kiheon, additional, Baker, Aaron B., additional, Bakht, Syeda Mahwish, additional, Bandyopadhyay, Amit, additional, Barchowsky, Aaron, additional, Bass, Garrett, additional, Becker, Matthew L., additional, Belleghem, Sarah Miho Van, additional, Benoit, Danielle S.W., additional, Biesiekierski, Arne, additional, Billiar, Kristen L., additional, Bose, Susmita, additional, Bowman, Christopher, additional, Boyce, Steven, additional, Brown, Bryan N., additional, Brown, Justin L., additional, Capadona, Jeffrey R., additional, Castner, David G., additional, Chang, Calvin, additional, Chang, Philip, additional, Chilkoti, Ashutosh, additional, Christman, Karen L., additional, Chung, Sangwon, additional, Coleman, Kelly P., additional, Conway, Dan, additional, Cook, Keith E., additional, Cooper, Stuart L., additional, Cosgriff-Hernandez, Elizabeth, additional, Coury, Arthur J., additional, Criscione, Joseph D., additional, Culver, Heidi, additional, Curtis, Jim, additional, Deng, Feiyang, additional, Dhavalikar, Prachi, additional, Diaz-Gomez, Luis, additional, Domingues, Rui M.A., additional, Duncan, Elaine, additional, Duran, Pamela, additional, Esbrit, Pedro, additional, Eskin, Suzanne G., additional, Esmail, Michael Y., additional, Ferracane, Jack L., additional, Fischbach, Claudia, additional, Fischman, Gary, additional, Fisher, John P., additional, Francolini, Iolanda, additional, Frey, Steven J., additional, Gaharwar, Akhilesh K., additional, García, Andrés J., additional, Gibson, Iain R., additional, Gilbert, Jeremy L., additional, Ginn, Brian, additional, Goldblatt, Zachary E., additional, Goldenberg, Seth J., additional, Gomes, Manuela E., additional, Gómez-Florit, Manuel, additional, Gonçalves, Inês C., additional, Gorbet, Maud B., additional, Grainger, David W., additional, Grody, Miles, additional, Guda, Teja, additional, Guelcher, Scott A., additional, Guiseppi-Elie, Anthony, additional, Hacking, S. Adam, additional, Hallab, Nadim James, additional, Hall-Stoodley, Luanne, additional, Hanson, Stephen R., additional, Han, Woojin M., additional, Harman, Melinda K., additional, Harrington, Roger, additional, Haschak, Martin J., additional, Heath, Daniel E., additional, Hicks, Emily Anne, additional, Hill, Ryan T., additional, Hoffman, Allan S., additional, Horbett, Thomas A., additional, Hubbell, Jeffrey A., additional, Ipek, Rasim, additional, Jacobs, Joshua J., additional, Jang, Young C., additional, Jiang, Shaoyi, additional, Johnson, Richard J., additional, Jones, Julian R., additional, Jo, Vickie Y., additional, Kane, Ravi S., additional, Kaplan, David L., additional, Kar, Ronit, additional, Keselowsky, Benjamin George, additional, Khademhosseini, Ali, additional, Kim, Yu Seon, additional, King, Martin W., additional, Kohane, Daniel S., additional, Kohn, David H., additional, Kuhn, Liisa T., additional, Kulkarni, Mangesh, additional, Kuo, Catherine K., additional, Lai, Angela, additional, Lambert, Bryron, additional, Lan, Ziyang, additional, Latour, Robert A., additional, Laurencin, Cato T., additional, Lawson, Bryan K., additional, Layland, Shannon Lee, additional, Lee, Jae Sung, additional, Lee-Parritz, David, additional, Lei, Ying, additional, Lemons, Jack E., additional, Levy, Robert J., additional, Lewerenz, Gregory M., additional, Lewis, Jamal S., additional, Liebscher, Simone, additional, Lin, Chien-Chi, additional, Livingston, Natalie K., additional, Li, Yang, additional, Li, Yuncang, additional, Lu, Helen, additional, Macdougall, Laura, additional, Mahadik, Bhushan, additional, Mamidwar, Sachin, additional, Manspeaker, Margaret P., additional, Mao, Hai-Quan, additional, Ma, Peter X., additional, Marcet, Tyler, additional, Martin, Jeffrey, additional, Martins, M. Cristina L., additional, McArthur, Sally L., additional, McGill, Meghan, additional, McIntire, Larry V., additional, Mei, Lei, additional, Mendes, Bárbara B., additional, Mikos, Antonios G., additional, Mitchell, Richard N., additional, Mitra, Indranath, additional, Muirhead, Ben, additional, Munir, Khurram, additional, Murphy, William L., additional, Nguyen, Phong K., additional, Nolfi, Alexis L., additional, Overby, Clyde, additional, Ozan, Sertan, additional, Padera, Robert F., additional, Pearce, Hannah A., additional, Peppas, Nicholas A., additional, Pereira, Andreia T., additional, Pfeifer, Carmem S., additional, Pinto, Artur M., additional, Raia, Nicole R., additional, Rankin, Edward A., additional, Ratner, Buddy D., additional, Regi, Maria Vallet, additional, Reis, Rui L., additional, Ritchie, Alastair Campbell, additional, Sakiyama-Elbert, Shelly E., additional, Salhadar, Karim, additional, Salinas, Antonio J., additional, Schenke-Layland, Katja, additional, Schoen, Frederick J., additional, Schutrum, Brittany E., additional, Sefton, Michael V., additional, Seidman, Michael A., additional, Shah, Darshan S., additional, Sheardown, Heather, additional, Shoffstall, Andrew J., additional, Simon, Carl G., additional, Simon, Josh, additional, Sims Jr., Kenneth R., additional, Slack, Steven M., additional, Slavin, Benjamin, additional, Snodderly, Kirstie Lane, additional, Stayton, Patrick S., additional, Steichen, Stephanie D., additional, Stoodley, Paul, additional, Swanson, W. Benton, additional, Tam, Hobey, additional, Tayab, Aftab, additional, Thomas, Susan N., additional, Traxel, Kellen D., additional, Tuan, Rocky S., additional, Tucker, Erik I., additional, Ukita, Rei, additional, Veith, Austin, additional, Vidal Yucha, Sarah E., additional, Viney, Christopher, additional, Vyavahare, Naren, additional, Wagner, William R., additional, Wang, Min, additional, Wang, Raymond M., additional, Warner, Petra, additional, Wen, Cuie, additional, West, Jennifer L., additional, Whitman, Matthew A., additional, Witte, Frank, additional, Wolf, Michael F., additional, Yao, Zhicheng, additional, Yaszemski, Michael, additional, Yaszemski, Michael J., additional, Yin, Lichen, additional, Zhang, Guigen, additional, Zhang, Peng, additional, Zhong, Zhiyuan, additional, and Ziats, Nicholas P., additional

Published
2020
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29. A Multi-Phase Modeling Framework Suitable for Dynamic Applications

Author

Barton, Nathan R., primary, Luscher, Darby J., additional, Battaile, Corbett, additional, Brown, Justin L., additional, Buechler, Miles, additional, Burakovsky, Leonid, additional, Crockett, Scott, additional, Greeff, Carl, additional, Mattsson, Ann E., additional, Prime, Michael B., additional, and Schill, William J., additional

Published
2022
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30. Lessons for conservation from beneath the pavement

Author

Mychajliw, Alexis M., primary, Ellwood, Elizabeth R., additional, Alagona, Peter S., additional, Anderson, R. Scott, additional, Balisi, Mairin A., additional, Biber, Eric, additional, Brown, Justin L., additional, George, Jessie, additional, Hendy, Austin J. W., additional, Higgins, Lila, additional, Hofman, Courtney A., additional, Leger, Ashley, additional, Ordeñana, Miguel A., additional, Pauly, Gregory B., additional, Putman, Breanna J., additional, Randall, John M., additional, Riley, Seth P. D., additional, Shultz, Allison J., additional, Stegner, M. Allison, additional, Wake, Thomas A., additional, and Lindsey, Emily L., additional

Published
2022
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38. Additional file 1 of Renal 99mTc-DMSA pharmacokinetics in pediatric patients

Author

Plyku, Donika, Ghaly, Michael, Li, Ye, Brown, Justin L., O’Reilly, Shannon, Khamwan, Kitiwat, Goodkind, Alison B., Sexton-Stallone, Briana, Cao, Xinhua, Zurakowski, David, Fahey, Frederic H., Treves, S. Ted, Bolch, Wesley E., Frey, Eric C., and Sgouros, George

Abstract

Additional file 1: Table 1. Patients’ Characteristics Data.

Published
2021
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39. Contributors

Author

Aravamudhan, Aja, primary, Banik, Brittany L., additional, Battig, Mark R., additional, Brocchini, Steve, additional, Brown, Justin L., additional, Burg, Karen, additional, Burgess, Diane J., additional, Carmali, Sheiliza, additional, Dang, Tram T., additional, Deng, Meng, additional, Domb, Abraham (Avi), additional, Duvvuri, Lakshmi Sailaja, additional, Eameema, Muntimadugu, additional, Elisseeff, Jennifer, additional, Fard, Sahar E., additional, Gu, Bing, additional, Guo, Jinshan, additional, Gupta, Umesh, additional, Harmon, Matthew D., additional, Heiny, Markus, additional, Jain, Anjana, additional, James, Roshan, additional, Jiang, Tao, additional, Kamble, Ravindra R., additional, Kariduraganavar, Mahadevappa Y., additional, Karumbaiah, Lohitash, additional, Khademhosseini, Ali, additional, Khan, Wahid, additional, Kittur, Arjumand A., additional, Kumbar, Sangamesh G., additional, Laurencin, Cato T., additional, Lee, Paul, additional, Memic, Adnan, additional, Murase, Sara K., additional, Nada, Ahmed A., additional, Nagarale, Rajaram K., additional, Nguyen, Dianna Y., additional, Nikkhah, Mehdi, additional, Parthasarathy, Meera, additional, Perumal, Omathanu, additional, Puiggalí, Jordi, additional, Qaqish, Walid P., additional, Ramos, Daisy M., additional, Rassias, Dina, additional, Saxena, Tarun, additional, Sethuraman, Swaminathan, additional, Shah, Kush N., additional, Shastri, Venkatram Prasad, additional, Shelke, Namdev B., additional, Subramaniam, Anuradha, additional, Tang, Xiaoyan, additional, Thankappan, Shalumon Kottappally, additional, Tran, Katelyn, additional, Tran, Richard T., additional, Valmikinathan, Chandra M., additional, Wang, Yong, additional, Wu, Iwen, additional, Wurth, Jonathan Johannes, additional, Xie, Zhiwei, additional, Yang, Jian, additional, Yin, Yuan, additional, Yu, Xiaojun, additional, and Yun, Yang H., additional

Published
2014
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43. Dosimetric considerations of99mTc-MDP uptake within the epiphyseal plates of the long bones of pediatric patients

Author

Brown, Justin L, primary, Sexton-Stallone, Briana, additional, Li, Ye, additional, Frey, Eric C, additional, Treves, S Ted, additional, Fahey, Frederic H, additional, Plyku, Donika, additional, Cao, Xinhua, additional, Choi, Chansoo, additional, Kim, Chan Hyeong, additional, Sgouros, George, additional, Aris, John P, additional, and Bolch, Wesley E, additional

Published
2020
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45. Contributors

Author

Abramson, Sascha, primary, Ackermann, D. Michael, additional, Akins, Robert, additional, Anders, Richard, additional, Andersen, Phillip J., additional, Anderson, James M., additional, Ankrum, James A., additional, Anseth, Kristi S., additional, Antonucci, Joe, additional, Atzet, Sarah, additional, Badylak, Stephen F., additional, Baura, Gail D., additional, Bellamkonda, Ravi V., additional, Best, Serena M., additional, Bhumiratana, Sarindr, additional, Bianco, Richard W., additional, Bokros, Jack C., additional, Borovetz, Harvey S., additional, Boskey, Adele L., additional, Brown, Justin L., additional, Brown, Bryan N., additional, Brown, Stanley A., additional, Brunski, John B., additional, Cahn, Fred, additional, Ritchie, Alastair Campbell, additional, Caplan, Arnold I., additional, Carpenedo, Richard L., additional, Chilkoti, Ashutosh, additional, Chung, Sangwon, additional, Cimetta, Elisa, additional, Cleary, Gary, additional, Clements, Isaac P., additional, Colas, André, additional, Coleman, Kelly P., additional, Conway, Daniel E., additional, Cooper, Stuart L., additional, Costerton, Bill, additional, Coury, Arthur J., additional, Cunanan, Crystal, additional, Curtis, Jim, additional, D’Amore, Antonio, additional, DeMeo, Patrick, additional, Desai, Tejal A., additional, Dickens, Sabine, additional, Domingo, Gonzalo, additional, Duncan, Elaine, additional, Eskin, Suzanne G., additional, Feigal, David W., additional, Ferreira, Lino, additional, Fuller, Jason, additional, Gallegos, Robert P., additional, Gawalt, Ellen, additional, Ghosh, Kaustabh, additional, Ghosn, Bilal, additional, Gilbert, Thomas W., additional, Glaser, Drew Elizabeth, additional, Godier-Furnemont, Amandine, additional, Gombotz, Wayne R., additional, Grainger, David W., additional, Grunkemeier, Gary L., additional, Hacking, S. Adam, additional, Hallab, Nadim James, additional, Hall-Stoodley, Luanne, additional, Hanson, Stephen R., additional, Haubold, Axel D., additional, Hauch, Kip D., additional, Hawkins, Kenneth R., additional, Heath, Daniel E., additional, Helm, Douglas L., additional, Hench, Larry L., additional, Hensten, Arne, additional, Hill, Ryan T., additional, Hobson, Christopher, additional, Hoerstrup, Simon P., additional, Hoffman, Allan S., additional, Horbett, Thomas A., additional, Hubbell, Jeffrey A., additional, Humayun, Mark S., additional, Ideker, Ray, additional, Ingber, Donald E., additional, Jain, Rakhi, additional, Jacob, Jean, additional, Jacobs, Joshua James, additional, Jacobsen, Nils, additional, Jin, Ruyun, additional, Johnson, Richard J., additional, Karp, Jeffrey M., additional, Kasper, F. Kurtis, additional, Kathju, Sandeep, additional, Khademhosseini, Ali, additional, Kim, Sungwon, additional, King, Martin W., additional, Kleiner, Lothar W., additional, Kohn, Joachim, additional, Koschwanez, Heidi E., additional, Kumbar, Sangamesh G., additional, Kuo, Catherine K., additional, LaFleur, Lisa, additional, Lahti, Matthew T., additional, Lambert, Byron, additional, Langer, Robert, additional, Laurencin, Cato T., additional, Lee-Parritz, David, additional, Lemons, Jack E., additional, Levin, Mark, additional, Levy, Robert J., additional, Lewerenz, Gregory M., additional, Li, Wan-Ju, additional, Lin, Chien-Chi, additional, Liu, Fang, additional, Lowrie, William G., additional, Lu, Ying, additional, Lysaght, Michael J., additional, Maidhof, Robert, additional, Mansbridge, J.N., additional, Cristina, M., additional, Martins, L., additional, Martin, Jeffrey, additional, Mayesh, Jay P., additional, McDevitt, Todd C., additional, McIntire, Larry V., additional, Merrit, Katharine, additional, Migliaresi, Claudio, additional, Mikos, Antonios G., additional, Misch, Carl E., additional, Mitchell, Richard N., additional, More, Robert B., additional, Moss, Christa W., additional, Munson, Jennifer M., additional, Navarro, Melba, additional, Nerem, Robert M., additional, Ogawa, Rei, additional, Orgill, Britlyn D., additional, Orgill, Dennis P., additional, Padera, Robert F., additional, Pandit, Abhay, additional, Park, Kinam, additional, Patel, Anil S., additional, Peck, Roger B., additional, Peckham, P. Hunter, additional, Peppas, Nicholas A., additional, Pereira, Maria Nunes, additional, Planell, Josep, additional, Popat, Ketul C., additional, Prestwich, Glenn D., additional, Pun, Suzie H., additional, Rabolt, John, additional, Rainbow, Roshni S., additional, Rajab, Taufiek, additional, Ratner, Buddy D., additional, Reichert, William M., additional, Rivard, Andrew L., additional, Rowley, Adrian P., additional, Ruan, Gang, additional, Sacks, Michael, additional, Sarkar, Debanjan, additional, Schaefer, Sebastian, additional, Schmidt, Christine E., additional, Schoen, Frederick J., additional, Schutte, Stacey C., additional, Sefton, Michael V., additional, Shalaby, Shalaby W., additional, Shirtliff, Mark, additional, Simon, Marc A., additional, Singh, Milind, additional, Slack, Steven M., additional, Spelman, Francis A., additional, Starr, Albert, additional, Stayton, Patrick S., additional, Steinert, Roger, additional, Stoodley, Paul, additional, Suri, Shalu, additional, Swi Chang, Thomas Ming, additional, Tandon, Nina, additional, Tanguay, Armand R., additional, Taylor, M. Scott, additional, Teo, Grace S.L., additional, Thodeti, Charles K., additional, Tolkoff, Joshua, additional, Treiser, Matthew, additional, Tuan, Rocky S., additional, Tucker, Erik I., additional, Venugopalan, Ramakrishna, additional, Vicari, Angela R., additional, Viney, Christopher, additional, Voight, Jessica M., additional, Vunjak-Novakovic, Gordana, additional, Wagner, William R., additional, Wang, Lian, additional, Wasiluk, Karen R., additional, Watts, David Christopher, additional, Weigl, Bernhard H., additional, Weiland, James D., additional, Whalen, John J., additional, Williams, David F., additional, Williams, Rachel L., additional, Wilson, John T., additional, Wilson, Clive G., additional, Winter, Jessica, additional, Wolf, Michael F., additional, Wright, Jeremy C., additional, Yager, Paul, additional, and Zhao, Weian, additional

Published
2013
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47. Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity.

Author

Bowers, Daniel T and Brown, Justin L

Subjects
NANOFIBERS, FIBROBLASTS, MECHANOTRANSDUCTION (Cytology), CURVATURE, RHO-associated kinases
Abstract

Mechanotransduction arises from information encoded in the shape of materials such as curvature. It induces activation of small GTPase signaling affecting cell phenotypes including differentiation. We carried out a set of preliminary experiments to test the hypothesis that curvature (1/radius) would also affect cell motility due to signal pathway crosstalk. High molecular weight poly (methyl methacrylate) straight nanofibers were electrospun with curvature ranging from 41 to 1 μm−1 and collected on a passivated glass substrate. The fiber curvature increased mouse mesenchymal stem cell aspect ratio (P  < 0.02) and decreased cell area (P  < 0.01). Despite little effect on some motility patterns such as polarity and persistence, we found selected fiber curvatures can increase normalized random fibroblastic mouse embryonic cell (MEF) migration velocity close to 2.5 times compared with a flat surface (P  < 0.001). A maximum in the velocity curve occurred near 2.5 μm−1 and may vary with the time since initiation of attachment to the surface (range of 0–20 h). In the middle range of fiber curvatures, the relative relationship to curvature was similar regardless of treatment with Rho-kinase inhibitor (Y27632) or cdc42 inhibitor (ML141), although it was decreased on most curvatures (P  < 0.05). However, below a critical curvature threshold MEFs may not be able to distinguish shallow curvature from a flat surface, while still being affected by contact guidance. The preliminary data in this manuscript suggested the large low curvature fibers were interpreted in a manner similar to a non-curved surface. Thus, curvature is a biomaterial construct design parameter that should be considered when specific biological responses are desired. Statement of integration, innovation, and insight   Replacement of damaged or diseased tissues that cannot otherwise regenerate is transforming modern medicine. However, the extent to which we can rationally design materials to affect cellular outcomes remains low. Knowing the effect of material stiffness and diameter on stem cell differentiation, we investigated cell migration and signaling on fibrous scaffolds. By investigating diameters across orders of magnitude (50–2000 nm), we identified a velocity maximum of ~800 nm. Furthermore, the results suggest large fibers may not be interpreted by single cells as a curved surface. This work presents insight into the design of constructs for engineering tissues. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

Author

Xia, Baoyun, primary, Blount, Benjamin C, additional, Guillot, Tonya, additional, Brosius, Christina, additional, Li, Yao, additional, Van Bemmel, Dana M, additional, Kimmel, Heather L, additional, Chang, Cindy M, additional, Borek, Nicolette, additional, Edwards, Kathryn C, additional, Lawrence, Charlie, additional, Hyland, Andrew, additional, Goniewicz, Maciej L, additional, Pine, Brittany N, additional, Xia, Yang, additional, Bernert, John T, additional, De Castro, B Rey, additional, Lee, John, additional, Brown, Justin L, additional, Arnstein, Stephen, additional, Choi, Diane, additional, Wade, Erin L, additional, Hatsukami, Dorothy, additional, Ervies, Gladys, additional, Cobos, Angel, additional, Nicodemus, Keegan, additional, Freeman, Dana, additional, Hecht, Stephen S, additional, Conway, Kevin, additional, and Wang, Lanqing, additional

Published
2020
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