346 results on '"Brown, Kevin R."'
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2. NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
3. Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors
4. Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
5. Multi-level cellular and functional annotation of single-cell transcriptomes using scPipeline
6. Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline
7. TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing
8. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
9. Functional genomics identifies new synergistic therapies for retinoblastoma
10. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
11. Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
12. Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells
13. High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells
14. Supplementary Figure from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
15. Data from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
16. Supplementary Table from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
17. Supplementary Table 5a from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
18. Supplementary Figures 1-8 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
19. Supplementary Table 2 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
20. Supplementary Table 1 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
21. Supplementary Table 6 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
22. Supplementary Table 3 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
23. Supplementary Methods from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
24. Supplementary Table 7 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
25. Data from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
26. Supplementary Table 8 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
27. Supplementary Table 9 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
28. Supplementary Table 4 from Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
29. Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells
30. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes
31. Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer
32. Supplementary Figure Legends from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
33. Supplementary Methods and References from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
34. Supplementary Table S9 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
35. Data from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
36. Supplementary Figures S1-S14 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
37. Evaluating Chromatin Regulators in Cancer Cell Lines Through RNAi-Glasses
38. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
39. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
40. RNAi screen identifies essential regulators of human brain metastasis-initiating cells
41. Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma
42. Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
43. High-Throughput Screening of Protein Interaction Networks in the TGFβ Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression
44. Multi-level cellular and functional annotation of single-cell transcriptomes
45. Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
46. TMOD-15. CHARACTERIZATION OF THE MINIMAL RESIDUAL DISEASE STATE REVEALS DISTINCT EVOLUTIONARY TRAJECTORIES OF HUMAN GLIOBLASTOMA
47. STEM-05. FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND UNRECOGNIZED PATHWAY DEPENDENCIES IN RECURRENT GLIOBLASTOMA
48. Identification of five important genes to predict GBM subtypes
49. Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; ACE2
50. A method for benchmarking genetic screens reveals a predominant mitochondrial bias
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