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6. Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs

Author

Sieber, Frederick E., Brown, Phillip R., Koehler, Raymmond C., and Traystman, Richard J.

Subjects
Diabetes -- Physiological aspects, Glucose -- Physiological aspects, Brain -- Physiological aspects, Biological sciences
Abstract

The effects of diabetes on cerebral oxygen uptake (CMRO2) and cerebral blood flow (CBF) were examined using chronically diabetic dogs. The dogs were anesthetized with fentanyl and pentobarbital and subjected top sham surgery or pancreatectomy. Diabetes and hypoglycemia caused a decrease in cerebrovascular resistance and an increase in CBF. The low and high-level insulin groups showed that the elevated CMRO2 produced a rise in CBF during anesthesia. No impairment of cerebrovascular CO2 responsivity among the diabetic groups was observed.

Published
1993

8. HIV prevalence at reception into Australian prisons, 1991-1997

Author

McDonald, Ann M., Ryan, James W., Brown, Phillip R., Manners, Chris J., Falconer, Anthony D., Kinnear, Raylee C., Harvey, William J., Hearne, Peter R., Banaszczyk, Mick, and Kaldor, John M.

Subjects
HIV infection -- Statistics, Prisons -- Health aspects, Health surveys -- Research, Health
Abstract

Data from a national monitoring system in place after 1991 in Australia indicate that prevalence of HIV infection among those entering prisons was low and that rates of HIV antibody testing were high.To measure the extent and outcome of HIV antibody testing of prisoners when they entered Australian prisons, a cross-sectional survey was carried out, 1991-97. HIV infection continues to be found in the group entering Australian prisons, as can be seen from the fact that people not known before to the prison health service to have HIV infection entered prison in each year. HIV prevalence in those entering prisons was at least three times that of the overall population.

Published
1999

11. Hepatitis B and C in New South Wales prisons: prevalence and risk factors

Author

Butler, Tony G., Dolan, Kate A., Ferson, Mark J., McGuinness, Linda M., Brown, Phillip R., and Robertson, Peter W.

Subjects
Hepatitis B -- Statistics, Hepatitis C -- Statistics, Hepatitis -- Risk factors, Prisoners -- Health aspects, Medicine, Preventive -- Prevention, Health
Abstract

Hepatitis B and hepatitis C in New South Wales prisons at entrance of inmates are discussed with information on prevalence and risk factors. It appears that about one-third of adult male entering prisoners may have been infected and that education and vaccination would be helpful in reducing transmission.

Published
1997

17. Occupational mortality from squamous cell carcinoma of the esophagus in the United States during 1991-1996.

Author

Salamat, Mehrdad, Brown, Phillip R., Magee, Carolyn A., Reyes, Diane K., Peters, David N., Venbrux, Anthony C., Cucino, Claudia, and Sonnenberg, Amnon

Subjects
DRUG delivery devices, CATHETERS, MEDICAL equipment, DRUG infusion pumps, COMPARATIVE studies, ESOPHAGEAL tumors, RESEARCH methodology, MEDICAL cooperation, OCCUPATIONAL diseases, OCCUPATIONS, RESEARCH, SQUAMOUS cell carcinoma, OCCUPATIONAL hazards, ENVIRONMENTAL exposure, EVALUATION research
Abstract

PURPOSE: To evaluate a new transcatheter device suitable for arterial embolization in an animal model. MATERIALS AND METHODS: A new prototype self-expanding braided embolic device (Embolizor), consisting of nitinol wire strands fixed at either end with platinum-iridium bands and covered with a film of polyethylene, was deployed through 5-F diagnostic catheters into renal artery branches in five swine. Standard stainless-steel spring coils were deployed in other renal branches and served as controls. The animals underwent follow-up selective renal arteriography to determine presence or absence of vessel recanalization or device migration 15–23 days after device deployment. Histopathologic evaluation of target vessels and peripheral renal parenchyma was also performed. RESULTS: Ten Embolizors and 10 stainless-steel coils were deployed in arteries ranging in size from 1.8 to 3.0 mm in diameter. The Embolizor was easily and precisely deployed. Angiographic evidence of vascular occlusion in the Embolizor group was noted within 30 seconds in eight device deployments and within 5 minutes in two. No early or delayed device migration was noted on follow-up arteriography. In the control group, seven of 10 previously occluded arteries were recanalized. No recanalization was noted in the Embolizor group. Light microscopy revealed evidence of infarction in all specimens examined. Whereas three specimens in the Embolizor group contained occasional giant cells, there were numerous multinucleated giant cells present within the interstices of all control spring coils. CONCLUSION: The Embolizor was easily, precisely, and successfully deployed through standard selective diagnostic angiographic catheters. Short-term follow-up demonstrated no recanalization or migration of the device. The Embolizor was shown on histopathologic analysis to have no significant foreign body reaction. [Copyright &y& Elsevier]

Published
2002
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