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1. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

Author

Pereira, Matthew, Hardwick, Susie, Messahel, Shrouk, Noblet, Joanne, Lee, Elizabeth D, Greenwood-Bibby, Rachel, Buchanan, Mark, Lewis, Lucy, Hughes, Sharon, Hartshorn, Stuart, Rogers, Louise, Hopkins, Juliet, Lyttle, Mark D, Fernandez, Daphin, Potter, Sarah, Lavigne-Smith, Holly R, Moulsdale, Phoebe, Smith, Alice, Bingham, Tracey, Ross, James, Ramsey, Natasha, Hacking, Jo, Mullen, Niall, Corrigan, Paul P, Prudhoe, Sarah, Faza, Hani, Robinson, Gisela, Sunley, Rachel C, Smith, Coral J, Unsworth, Vanessa, Criddle, John, Laque, Martin, Sheedy, Alyce B, Anderson, Mark, Bell, Kathryn, Devine, Kirsty, Scott, Alex, Kumar, Ramesh, Armstrong, Sonia, Sutherland, Emer, Cantle, Fleur, Helyer, Sinead, Riozzi, Paul, Cotton, Hannah, Downes, Alice J, Mollard, Helen, Roland, Damian, Hay, Felix, Gough, Christopher, Finucane, Sonya, Bevan, Catherine, Ramsay, Rebecca, Walton, Emily, Maney, Julie-Ann, Dalzell, Elizabeth, Millar, Muriel, Howells, Rachel J, Appelboam, Andy, Mackle, Daisy, Small, Jennie, Neil, Ashleigh, Choudhery, Vince, MacLeod, Stewart, Browning, Jen, O'Neill, Thomas, Grahamslaw, Julia, Parikh, Ami, Skene, Imogen, Thomas, Rhys, Potier de la Morandiere, Katherine, Wilson, Jill L, Danziger, Donna, Burke, Derek, Ramlakhan, Shammi, Evans, Jayne, Morcombe, Julie, Gormley, Stuart, Barling, Jason M, Cathie, Katrina, Bayreuther, Jane, Ensom, Ruth, Iqbal, Yasser, Rounding, Sarah, Mulligan, Joanne, Bell, Claire, McLellan, Shona, Leighton, Shona, Sajjanhar, Tina, Nyirenda, Maggie, Crome, Laura, Williamson, Neil, Alcock, Anastasia, Edwards, Sara, Morgan, Jeff, Powell, Colin VE, Ramesh, Chaniyil A, Kamal-Uddin, Solomon, Linney, Mike, Vamvakiti, Katia, Floyd, Sharon, Hobden, Gill, Rainford, Naomi E A, Gamble, Carrol, Humphreys, Amy, Hickey, Helen, Woolfall, Kerry, Roper, Louise, Tate, Paul, Iyer, Anand, Evans, Vicki, and Appleton, Richard E

Published
2019
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2. Maternal views on RSV vaccination during the first season of implementation in England and Scotland

Author

Middleton, Catriona, Connon, Maggie, Paxton, Jill, Thomson, Nicola, Baker, James, Hardwick, Susie R, Fraser, Karena, Kimber, Kathryn Frances, French, Asa JE, Tolhurst-Cleaver, Meriel, Siner, Sarah, Fletcher, Stephen, Geoghegan, Karen, Tremarco, Laura, Diaba, Cynthia Dzokoto, Iheanetu-Oguejiofor, Chidinma Joanne, Dolma, Lobsong, Ruo, Stephen Waithaka, Berg, Richard Benjamin Stuart, Farah, Sara Mohammed Osman, Whitehouse, Abigail Louise, Wild, Grace E, Siraj, Sobia, Kyrgios, Ioannis, Anpananthar, Amutha, Tubman, Lee James, Bhopal, Sunil S, Reynolds, Jessica, Larkin, Gabrielle, Ledger, Elizabeth, Bonsor, Ruth E, Stuart, Mat, O'Kelly, Alison, Deleonardis, Chiara, Brearey, Stephen P, Burchett, Caroline A, de-Beger, Sarah E, Bell, Claire, Benjamin, Babu G, Farmer, Sarah E, Gopi, Mudiyur, Browning, Jen, Blackstock, Caroline, O'Brien, Rachel, Gomes, Sylvester S, Woods, Gracita, Jarman, Heather J, Karame, Zee R, Foster, Steve J, Cathcart, Susanne, Edwards, Louise E, Poole-Cowley, James R, Hunt, Samantha E, Tomlinson, Joanne L, Tillett, Jo William, Dowson, Simon, Singham, Surendra T, Palmer, Perpetual S, Grant, Eilidh E, Miller, Pauline, Perera, Kelum K, Stares, Jasmine L, Brazil, Manuela E, Gardner, Sharryn, Bowness, Kerri, Morrison, Moira, Richens, Nicholas, Deall, Heather, Parratt, Jemma, Grigsby, Stephanie, Vanner, Nina, Diaz, Francesca, Johnson, Graham, Riley, Jonathan, Fletcher, Alison, Bub, Katie Louise, Hamson, George R, Evans, Jessica J, Griffiths, Virginia J, Diment, Sarah L, Gray, Sebastian J, Furness, Nikki Leanne, Gormley, Stuart, Scott, Rebecca, Bamber, Victoria, Jones, Kathryn, Fairlie, Louise A, Nunes, Rophy Ganancial, O'Leary, Clare, Burridge, Richard George, Hall, Katrina S, Taylor, Leanne M, Kirkpatrick, Lily, Jamall, Erum, Williams, Thomas C, Marlow, Robin, Cunningham, Steve, Drysdale, Simon B, Groves, Helen, Iskander, Dalia, Liu, Xinxue, Lyttle, Mark D, Mpamhanga, Chengetai D, O'Hagan, Shaun, Waterfield, Thomas, and Roland, Damian

Published
2025
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3. BASF

Author

Browning, Jen

Subjects
Fire ants, Business, Sports, sporting goods and toys industry
Abstract

The easiest way to control native and imported fire ants is with insecticide fire ant baits like Siesta. This material is a highly attractive bait matrix formulated specifically for fire [...]

Published
2023

4. Point-of-care testing in paediatric settings in the UK and Ireland: A cross-sectional study

Author

Pandey, Meenu, Lyttle, Mark D., Cathie, Katrina, Munro, Alasdair, Waterfield, Thomas, Roland, Damian, Boyle, Adrian, Heinz, Peter, Messahel, Shrouk, Hawcutt, Dan, Ponmani, Caroline, Bird, Chris, Jyothish, Deepthi, Williams, Catherine, O’Sullivan, Ronan, Jones, Elizabeth, Lyttle, Mark, Sargant, Nwanneka, Ross, James, Barrett, Michael, Harty, Sinead, Bolger, Turlough, Coghlan, David, Fitzpatrick, Patrick, Hensey, Conor, Hussan, Tim, Charlick, Kate, Verling, William, Christian, Peter, Clark, Matthew, Shah, Bhavni, Criddle, John, Cheung, Ronny, Alcock, Roger, Aldridge, Patrick, Peek, Russell, Anderson, Mark, Herrieven, Elizabeth, Jerman, Katherine, Murad, Arshid, Brown, Charlotte, Marshall, Andy, Cantle, Fleur, Wilson, Gavin, Downes, Alice, Bandi, Srini, Da-Costa, Adebayo, Barry, Ray, De Vere, Natasha, Dieppe, Clare, Evans, Jane, Hann, Gayle, Tipper, Clare, Bassay, Bengisu, Dalton, Dermot, Fraser, Lauren, Gough, Chris, Gardner, Sharryn, Tighe, Mark, Ranasinghe, Darren, Birch, Simon, Hall, Sharon, Patton, Gareth, Turner, Steve, Walton, Emily, Maney, Julie Ann, Bourke, Tom, Thakker, Manish, Robinson, Gisela, Starkey, Lizzie, Appelboam, Andrew, Wong, Shye Wei, Foster, Steven, Pollock, Louisa, Browning, Jen, Potier, Katherine, Challen, Kirsty, Gilby, Elizabeth, Kehler, Lisa, Gray, Sebastian, Ramlakhan, Shammi, Mullen, Niall, Bayreuther, Jane, Jarman, Heather, Thompson, Neil, Parikh, Ami, Paul, Siba, Trippick, Sarah, Sutcliffe, Alastair, Mulligan, Joanne, Keers, Sophie, Morgan, Jeff, Jacobs, Michelle, Linney, Mike, Wilson, Sarah, Jamall, Erum, and On behalf of GAPRUKI, PERUKI

Subjects
Emergency Medicine
Abstract

Background: Point-of-care testing (POCT) is diagnostic testing performed at or near to the site of the patient. Understanding the current capacity, and scope, of POCT in this setting is essential in order to respond to new research evidence which may lead to wide implementation. Methods: A cross-sectional online survey study of POCT use was conducted between 6th January and 2nd February 2020 on behalf of two United Kingdom (UK) and Ireland-based paediatric research networks (Paediatric Emergency Research UK and Ireland, and General and Adolescent Paediatric Research UK and Ireland). Results: In total 91/109 (83.5%) sites responded, with some respondents providing details for multiple units on their site based on network membership (139 units in total). The most commonly performed POCT were blood sugar (137/139; 98.6%), urinalysis (134/139; 96.4%) and blood gas analysis (132/139; 95%). The use of POCT for Influenza/Respiratory Syncytial Virus (RSV) (45/139; 32.4%, 41/139; 29.5%), C-Reactive Protein (CRP) (13/139; 9.4%), Procalcitonin (PCT) (2/139; 1.4%) and Group A Streptococcus (5/139; 3.6%) and was relatively low. Obstacles to the introduction of new POCT included resources and infrastructure to support test performance and quality assurance. Conclusion: This survey demonstrates significant consensus in POCT practice in the UK and Ireland but highlights specific inequity in newer biomarkers, some which do not have support from national guidance. A clear strategy to overcome the key obstacles of funding, evidence base, and standardising variation will be essential if there is a drive toward increasing implementation of POCT.

Published
2022

5. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

Author

Lyttle, Mark D., Rainford, Naomi E.A., Gamble, Carrol, Messahel, Shrouk, Humphreys, Amy, Hickey, Helen, Woolfall, Kerry, Roper, Louise, Noblet, Joanne, Lee, Elizabeth D., Potter, Sarah, Tate, Paul, Iyer, Anand, Evans, Vicki, Appleton, Richard E., Pereira, Matthew, Hardwick, Susie, Greenwood-Bibby, Rachel, Buchanan, Mark, Lewis, Lucy, Hughes, Sharon, Hartshorn, Stuart, Rogers, Louise, Hopkins, Juliet, Fernandez, Daphin, Lavigne-Smith, Holly R., Moulsdale, Phoebe, Smith, Alice, Bingham, Tracey, Ross, James, Ramsey, Natasha, Hacking, Jo, Mullen, Niall, Corrigan, Paul P., Prudhoe, Sarah, Faza, Hani, Robinson, Gisela, Sunley, Rachel C., Smith, Coral J., Unsworth, Vanessa, Criddle, John, Laque, Martin, Sheedy, Alyce B., Anderson, Mark, Bell, Kathryn, Devine, Kirsty, Scott, Alex, Kumar, Ramesh, Armstrong, Sonia, Sutherland, Emer, Cantle, Fleur, Helyer, Sinead, Riozzi, Paul, Cotton, Hannah, Downes, Alice J., Mollard, Helen, Roland, Damian, Hay, Felix, Gough, Christopher, Finucane, Sonya, Bevan, Catherine, Ramsay, Rebecca, Walton, Emily, Maney, Julie Ann, Dalzell, Elizabeth, Millar, Muriel, Howells, Rachel J., Appelboam, Andy, Mackle, Daisy, Small, Jennie, Neil, Ashleigh, Choudhery, Vince, MacLeod, Stewart, Browning, Jen, O'Neill, Thomas, Grahamslaw, Julia, Parikh, Ami, Skene, Imogen, Thomas, Rhys, Potier de la Morandiere, Katherine, Wilson, Jill L., Danziger, Donna, Burke, Derek, Ramlakhan, Shammi, Evans, Jayne, Morcombe, Julie, Gormley, Stuart, Barling, Jason M., Cathie, Katrina, Bayreuther, Jane, Ensom, Ruth, Iqbal, Yasser, Rounding, Sarah, Mulligan, Joanne, Bell, Claire, McLellan, Shona, Leighton, Shona, Sajjanhar, Tina, Nyirenda, Maggie, and Crome, Laura

Subjects
Centre for Health and Clinical Research, levetiracetam, phenytoin, convulsive status epilepticus, epilepsy, paediatric
Abstract

Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status epilepticus.Methods This open-label, randomised clinical trial was undertaken at 30 UK emergency departments at secondary and tertiary care centres. Participants aged 6 months to under 18 years, with convulsive status epilepticus requiring second-line treatment, were randomly assigned (1:1) using a computer-generated randomisation schedule to receive levetiracetam (40 mg/kg over 5 min) or phenytoin (20 mg/kg over at least 20 min), stratified by centre. The primary outcome was time from randomisation to cessation of convulsive status epilepticus, analysed in the modified intention-to-treat population (excluding those who did not require second-line treatment after randomisation and those who did not provide consent). This trial is registered with ISRCTN, number ISRCTN22567894.Findings Between July 17, 2015, and April 7, 2018, 1432 patients were assessed for eligibility. After exclusion of ineligible patients, 404 patients were randomly assigned. After exclusion of those who did not require second-line treatment and those who did not consent, 286 randomised participants were treated and had available data: 152 allocated to levetiracetam, and 134 to phenytoin. Convulsive status epilepticus was terminated in 106 (70%) children in the levetiracetam group and in 86 (64%) in the phenytoin group. Median time from randomisation to cessation of convulsive status epilepticus was 35 min (IQR 20 to not assessable) in the levetiracetam group and 45 min (24 to not assessable) in the phenytoin group (hazard ratio 1·20, 95% CI 0·91–1·60; p=0·20). One participant who received levetiracetam followed by phenytoin died as a result of catastrophic cerebral oedema unrelated to either treatment. One participant who received phenytoin had serious adverse reactions related to study treatment (hypotension considered to be immediately life-threatening [a serious adverse reaction] and increased focal seizures and decreased consciousness considered to be medically significant [a suspected unexpected serious adverse reaction]). Interpretation Although levetiracetam was not significantly superior to phenytoin, the results, together with previously reported safety profiles and comparative ease of administration of levetiracetam, suggest it could be an appropriate alternative to phenytoin as the first-choice, second-line anticonvulsant in the treatment of paediatric convulsive status epilepticus.

Published
2019

8. BOOSTING BIOLOGICALS with Compatible Chemistries and Culture.

Author

Browning, Jen

Subjects
INSECT growth regulators, BIOLOGICALS, HEMIPTERA, INSECTICIDES, ACARICIDES
Abstract

This article, titled "BOOSTING BIOLOGICALS with Compatible Chemistries and Culture," discusses the integration of biological control agents (BCAs) with conventional sprays and chemical applications in agricultural practices. The article emphasizes the importance of choosing compatible chemistries and timing for successful integration. It suggests using targeted insecticides that control specific pest insects while minimizing effects on non-target insects and mites. Additionally, the article advises checking the compatibility of other products, such as pesticides, fungicides, and adjuvants, before mixing them in the tank. The article concludes by encouraging readers to learn more about this topic on the BASF website. [Extracted from the article]

Published
2024

10. Weeds got you down?

Author

Marble, Chris, Lookabaugh, Emma, and Browning, Jen

Published
2021

13. Seven Steps for Spider Mite IPM.

Author

BROWNING, JEN BERGH

Abstract

The article discusses the basic steps for spider mite integrated pest management (IPM).

Published
2015

14. Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception.

Author

Poonai N, Cohen DM, MacDowell D, Mistry RD, Mintegi S, Craig S, Roland D, Miller M, Shavit I, Wang Y, Nager A, Heyming T, Burns R, Trehan I, Lipshaw M, Sulton C, Li J, Ojo A, Kelly S, Thornton M, Caperell K, Amoni I, Abrams A, Duong M, Wassem M, Davis A, Gravel J, Doyon Trottier E, Bar Am N, Thompson G, Sabhaney V, Meckler G, Jain R, Ali S, Bressan S, Zangardi T, Villa G, Giacalone M, Seiler M, Sahyoun C, Romano F, Bognar Z, Hajosi-Kalcakosz S, Amir L, Hachimi-Idrissi S, Pucuka Z, Zviedre A, Zeltina E, Phillips N, Borland M, O'Brien S, Marchant J, Kochar A, George S, Pennington V, Lyttle M, Browning J, McLoughlin A, Hartshorn S, Urooj C, Johnston L, Walton E, Subrahmanyam Puthucode D, Peacock P, Conroy J, Marañon R, Garcia S, Cahís N, Cámara-Otegui A, Gomez A, Carbonero M, Angelats-Romero C, Yock-Corrales A, Hualde G, Spigariol F, Donas A, Gübeli Linné C, Rocchi A, Pedrazzini A, Cozzi G, Barbi D, Baggio L, La Fauci G, Mauro A, Steimle M, Buonsenso D, Ugalde I, Nieva G, Harper C, Sforzi I, and Jain S

Subjects
Male, Child, Humans, Adolescent, Female, Analgesics, Opioid therapeutic use, Cross-Sectional Studies, Intussusception complications, Intestinal Perforation etiology, Analgesia adverse effects
Abstract

Importance: Ileocolic intussusception is an important cause of intestinal obstruction in children. Reduction of ileocolic intussusception using air or fluid enema is the standard of care. This likely distressing procedure is usually performed without sedation or analgesia, but practice variation exists., Objective: To characterize the prevalence of opioid analgesia and sedation and assess their association with intestinal perforation and failed reduction., Design, Setting, and Participants: This cross-sectional study reviewed medical records of children aged 4 to 48 months with attempted reduction of ileocolic intussusception at 86 pediatric tertiary care institutions in 14 countries from January 2017 to December 2019. Of 3555 eligible medical records, 352 were excluded, and 3203 medical records were eligible. Data were analyzed in August 2022., Exposures: Reduction of ileocolic intussusception., Main Outcomes and Measures: The primary outcomes were opioid analgesia within 120 minutes of reduction based on the therapeutic window of IV morphine and sedation immediately before reduction of intussusception., Results: We included 3203 patients (median [IQR] age, 17 [9-27] months; 2054 of 3203 [64.1%] males). Opioid use was documented in 395 of 3134 patients (12.6%), sedation 334 of 3161 patients (10.6%), and opioids plus sedation in 178 of 3134 patients (5.7%). Perforation was uncommon and occurred in 13 of 3203 patients (0.4%). In the unadjusted analysis, opioids plus sedation (odds ratio [OR], 5.92; 95% CI, 1.28-27.42; P = .02) and a greater number of reduction attempts (OR, 1.48; 95% CI, 1.03-2.11; P = .03) were significantly associated with perforation. In the adjusted analysis, neither of these covariates remained significant. Reductions were successful in 2700 of 3184 attempts (84.8%). In the unadjusted analysis, younger age, no pain assessment at triage, opioids, longer duration of symptoms, hydrostatic enema, and gastrointestinal anomaly were significantly associated with failed reduction. In the adjusted analysis, only younger age (OR, 1.05 per month; 95% CI, 1.03-1.06 per month; P < .001), shorter duration of symptoms (OR, 0.96 per hour; 95% CI, 0.94-0.99 per hour; P = .002), and gastrointestinal anomaly (OR, 6.50; 95% CI, 2.04-20.64; P = .002) remained significant., Conclusions and Relevance: This cross-sectional study of pediatric ileocolic intussusception found that more than two-thirds of patients received neither analgesia nor sedation. Neither was associated with intestinal perforation or failed reduction, challenging the widespread practice of withholding analgesia and sedation for reduction of ileocolic intussusception in children.

Published
2023
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