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Objectives To examine the correlation between spheno-occipital synchondrosis fusion stages and the hand-wrist skeletal maturity index. Materials and Methods Digital records of 164 individuals (77 males, 87 females) aged 10 to 18 years old were examined. Three-dimensional CBCT scans and hand-wrist two-dimensional radiographs were scored for the spheno-occipital synchondrosis fusion stages and hand-wrist skeletal maturity index, respectively. Statistical analyses were performed for associations using R software with a significance threshold of P< .01. Results A significant positive relationship was demonstrated between spheno-occipital synchondrosis fusion stages and hand-wrist skeletal maturity in both sexes. The Kendall's rank correlation τ between hand-wrist skeletal maturity index and spheno-occipital synchondrosis fusion percentage were high and positive in males and females (r = .74 and r = .71, respectively). Conclusions The significant, positive relationship between the hand-wrist skeletal maturity index and spheno-occipital synchondrosis fusion stages support the idea of using spheno-occipital synchondrosis fusion as a biological indicator for craniofacial and mandibular growth spurt prediction.

This chapter describes and presents analysis of all vertebrae and ribs for the Sterkfontein hominins, including those associated with the Sts 14 and 431 skeletons. New rib fragments recently identified and accessioned with Sts 14 are included. Taken together, the vertebrae and ribs of the Sterkfontein hominins tell a consistent story. With one exception from Member 5 that may be attributable to Homo, all other specimens are consistent with being attributed to the same species, likely Australopithecus africanus. Overall, all the Sterkfontein specimens resemble those from other early hominins, reflecting a fundamentally human-like torso, with a series of sinusoidal spinal curvatures similar to those of hominins. These characteristics are distinctly human-like, are dissimilar from any other mammal, and are consistent with a fully upright posture. Sts 14 also displays two common spinal pathologies seen in humans but not in other hominoids, associated with the sinusoidal spinal curvatures that are necessary for habitual bipedality. The rib cage of the Sterkfontein hominins, although fragmentary, appears to indicate declination and torsion of the ribs, features that are unique to hominins. The Sterkfontein fossils also appear to have longer, thicker lower ribs than is typical for humans, but they lack costotransverse articulations at the second-to-last ribs. The thoracolumbar transition in the Sterkfontein hominins is like that of all other early hominins, with a facet transition occurring at the second to last rib-bearing level, rather than the last rib-bearing level as seen in extant humans and great apes. Overall, the Sterkfontein hominins displays rib and vertebral morphologies that among primates are only regularly seen in humans and are associated with habitually orthograde posture.

International audience; Studying endocasts has long allowed anthropologists to examine changes in the external topography and the overall size of the brain throughout the evolutionary history of hominins. The nearly complete calvaria of Manot 1 presents an opportunity to gain insights into the external brain morphology, vascular system, and dimensions of the brain of this late Middle Paleolithic hominin. Detailed size and shape analyses of the Manot 1 endocast indicate a modern Homo sapiens anatomy, despite the presence of some primitive features of the calvaria. Traits considered to be derived endocranial features for H. sapiens are present in Manot 1, including an elongated parietal sagittal chord with an elevated superior part of the hemisphere, a widened posterior part of the frontal lobes, a considerable development of the parietal reliefs such as the supramarginal lobules, and a slight posterior projection of the occipital lobes. These findings, together with data presented in previous studies, rule out the possibility of a direct Neanderthal ancestry for the Manot 1 hominin and instead confirm its affiliation with H. sapiens. The Manot 1 calvaria is more similar to that of later Upper Paleolithic H. sapiens than it is to the earlier Levantine populations of Skhul and Qafzeh. The late Middle Paleolithic date of Manot 1 provides an opportunity to analyze the recent developments in human cerebral morphology and organization.

Among living mammals, only the African apes and some anteaters adopt knuckle-walking as their primary locomotor behavior. That Pan and Gorilla both knuckle-walk has been cited as evidence of their common ancestry and a primitive condition for a combined Homo, Pan, and Gorilla clade. Recent research on forelimb ontogeny and anatomy, in addition to recently described hominin fossils, indicate that knuckle-walking was independently acquired after divergence of the Pan and Gorilla lineages. Although the large-bodied, largely suspensory orangutan shares some aspects of the African ape bauplan, it does not regularly knuckle-walk when terrestrial. While many anatomical correlates of knuckle-walking have been identified, a functional explanation of this unusual locomotor pattern has yet to be proposed. Here, we argue that it was adopted by African apes as a means of ameliorating the consequences of repetitive impact loadings on the soft and hard tissues of the forelimb by employing isometric and/or eccentric contraction of antebrachial musculature during terrestrial locomotion. Evidence of this adaptation can be found in the differential size and fiber geometry of the forearm musculature, and differences in torso shape between the knuckle-walking and non-knuckle-walking apes (including humans). We also argue that some osteological features of the carpus and metacarpus that have been identified as adaptations to knuckle-walking are consequences of cartilage remodeling during ontogeny rather than traits limiting motion in the hand and wrist. An understanding of the functional basis of knuckle-walking provides an explanation of the locomotor parallelisms in modern Pan and Gorilla. Anat Rec, 301:496-514, 2018. © 2018 Wiley Periodicals, Inc.

This study presents the dental remains discovered at Manot Cave (MC), Western Galilee, Israel. The cave contains evidence for human occupation during the Early Upper Paleolithic period (46–33 ka) mainly of Early Ahmarian (∼46–42 ka) and Levantine Aurignacian (∼38–34 ka) cultural levels. Six teeth (three deciduous and three permanent) were found at the site, of which four could be thoroughly analyzed. The morphology of the teeth was qualitatively described and analyzed using traditional and geometric morphometric methods. A large comparative sample was used in order to assess the morphological affiliation of the Manot specimens with other Homo groups. The results provided equivocal signals: the upper first premolar (MC-9 P3) is probably modern human; the upper deciduous second molar (MC-10 dm2) and the upper second permanent molar (MC-8 M2) might be modern humans; the lower second deciduous molar (MC-7 dm2) might be Neanderthal. Owing to the small sample size and the almost total lack of distinctive characteristics, our outcome could not supply conclusive evidence to address the question of whether Manot Aurignacian population came from Europe or descended from the local Ahmarian population.

The transition from the Middle Paleolithic to the Upper Paleolithic in the Levant represents a major event in human prehistory with regards to the dispersal of modern human populations. Unfortunately, the scarcity of human remains from this period has hampered our ability to study the anatomy of Upper Paleolithic populations. This study describes and examines pedal bones recovered from the Early Upper Paleolithic period at Manot Cave, Israel, from 2014 to 2017. The Manot Cave foot bones include a partial, left foot skeleton comprising a talus, a calcaneus, a cuboid, a first metatarsal, a second metatarsal, a fifth metatarsal, and a hallucal sesamoid. All these remains were found in the same archaeological unit of the cave and belong to a young adult. Shape and size comparisons with Neanderthals, Anatomically Modern Human and modern human foot bones indicate a modern human morphology. In some characteristics, however, the Manot Cave foot bones display a Neanderthal-like pattern. Notably, the Manot Cave foot is remarkable in its overall gracility. A healed traumatic injury in the second metatarsal (Lisfranc's fracture) is most likely due to a remote impact to the dorsum of the foot. This injury, its subsequent debility, and the individual's apparent recovery suggest that the members of the Manot Cave community had a supportive environment, one with mutual responsibilities among the members.

La periode comprise entre 60 000 et 50 000 ans BP est l’une des phases les plus importantes de l’evolution biologique humaine. Au cours de celle-ci, la partie occidentale de l’Eurasie (l’Europe et le Proche-Orient) a ete peuplee par les Neandertaliens, tandis que la partie orientale (Asie centrale et Siberie) l’a ete par les Denisoviens. Cependant, il y a plus de 30 000 ans, ces deux populations ont ete remplacees par des Hommes anatomiquement modernes. Quand sont apparus ces nouveaux arrivants, et d’ou venaient-ils ? Des donnees archeologiques et genetiques suggerent que ce changement demographique a eu lieu a la fin du stade isotopique marin 4 [1–3]. Une dispersion importante d’Hommes anatomiquement modernes en dehors du continent africain serait a la source de ces nouvelles populations [4–7]. Dans cette etude, nous examinons la possibilite que Manot 1 appartienne a la population de base qui a donne lieu a l’Homme moderne. En outre, les relations entre Manot 1 et la population du Paleolithique superieur d’Europe et les Neandertaliens levantins contemporains sont abordees. Dans cette etude, nous avons examine les caracteristiques morphologiques particulieres de Manot 1 (e.g. la fosse sus-iniaque) et evalue leurs similitudes avec les caracteres homologues presents chez les Neandertaliens. Nous avons montre que, bien que la terminologie soit identique, les caracteres de chaque groupe d’hominines representent des entites differentes. Nous avons aussi mis en evidence queManot 1 et les crânes du Paleolithique superieur ancien d’Europe ont beaucoup de caracteres en commun, bien que Manot 1 soit plus gracile. Pour finir, certains des caracteres archaiques observes sur le specimen de Manot 1 sont aussi visibles sur le crâne ethiopien d’Aduma date du Pleistocene final ou meme celui d’Eyasi 1, en Tanzanie.

This study examines the relationship between spheno-occipital synchondrosis (SOS) closure and puberty onset in a modern American population. It also investigates the timing and the rate of SOS closure in males and females.The sample includes cross-sectional and longitudinal 3D Cone Beam Computed Tomography (CBCT) scans of 741 individuals (361 males and 380 females) aged 6-20 years. Each CBCT scan is visualized in the mid-sagittal plane, and the spheno-occipital synchondrosis (SOS) is scored as completely open, partially fused, mostly fused, and completely fused. The Menarche commencement is used as an indicator of puberty onset in females.Mean ages of open, partially-fused, mostly-fused, and completely fused SOS were 11.07, 12.95, 14.44, and 16.41 years in males, and 9.75, 11.67, 13.25, and 15.25 in females, respectively. The results show there is a significant association between the SOS closure stage and the commencement of menarche (Fisher's Exact Test p0.001). It was found that females had a higher SOS closure rate (38.60%) per year than males at the age of 10 years. The closure rate in males appears slower than females at age 10, but it lasts a longer time, ranging between 22 and 26% per year from age 11 to 14 years.There is a significant relationship between puberty onset and SOS closure, suggesting its closure is at least partially affected by systemic, hormonal changes in the growing adolescent. Also, SOS closure occurs at a faster rate and at an earlier age in females compared to males.

Manot Cave radiocarbon dates establish Levantine chronology, which is critical for understanding Upper Paleolithic dispersals., The timing of archeological industries in the Levant is central for understanding the spread of modern humans with Upper Paleolithic traditions. We report a high-resolution radiocarbon chronology for Early Upper Paleolithic industries (Early Ahmarian and Levantine Aurignacian) from the newly excavated site of Manot Cave, Israel. The dates confirm that the Early Ahmarian industry was present by 46,000 calibrated years before the present (cal BP), and the Levantine Aurignacian occurred at least between 38,000 and 34,000 cal BP. This timing is consistent with proposed migrations or technological diffusions between the Near East and Europe. Specifically, the Ahmarian could have led to the development of the Protoaurignacian in Europe, and the Aurignacian in Europe could have spread back to the Near East as the Levantine Aurignacian.

Spontaneous vertebral fractures are a common occurrence in modern humans, yet these fractures are not documented in other hominoids. Differences in vertebral bone strength between humans and apes associated with trabecular bone microarchitecture may contribute to differences in fracture incidence. We used microcomputed tomography to examine trabecular bone microarchitecture in the T8 vertebra of extant young adult hominoids. Scaled volumes of interest from the anterior vertebral body were analyzed at a resolution of 46 microm, and bone volume fraction, trabecular thickness, trabecular number, trabecular separation, structure model index, and degree of anisotropy were compared among species. As body mass increased, so did trabecular thickness, but bone volume fraction, structure model index, and degree of anisotropy were independent of body mass. Bone volume fraction was not significantly different between the species. Degree of anisotropy was not significantly different among the species, suggesting similarity of loading patterns in the T8 vertebra due to similar anatomical and postural relationships within each species' spine. Degree of anisotropy was negatively correlated with bone volume fraction (r(2) = 0.85, P < 0.05) in humans, whereas the apes demonstrated no such relationship. This suggested that less dense human trabecular bone was more preferentially aligned to habitual loading. Furthermore, we theorize that trabeculae in ape thoracic vertebrae would not be expected to become preferentially aligned if bone volume fraction was decreased. The differing relationship between bone volume fraction and degree of anisotropy in humans and apes may cause less dense human bone to be more fragile than less dense ape bone.

The purpose of this study was to investigate whether helical tomotherapy would better dose-limit growing vertebral ring apophyses during craniospinal radiation as compared to conventional techniques. Four pediatric patients with M0 medulloblastoma received tomotherapy craniospinal radiation (23.4 Gy, 1.8 Gy/fx) by continuous helical delivery of 6 MV photons. Weekly blood counts were monitored. For comparison, conventional craniospinal radiation plans were generated. To assist in tomotherapy planning, a cross-sectional growth study of 52 children and young adults was completed to evaluate spine growth and maturation. Vertebral ring apophyses first fused along the posterolateral body-pedicle synostosis, proceeding circumferentially toward the anterior vertebral body such that the cervical and lumbar vertebrae fused early and mid-thoracic vertebrae fused late. For the four pediatric patients, tomotherapy resulted between 2% and 14% vertebral volume exceeding 23 Gy. Conventional craniospinal radiation predicted between 33% and 44% exceeding 23 Gy. Cumulative body radiation doses exceeding 4 Gy were between 50% and 57% for tomotherapy and between 25% and 37% for conventional craniospinal radiation. Tomotherapy radiation reduced neutrophil, platelet, and erythrocyte hemoglobin levels during treatment. Tomotherapy provides improved dose avoidance to growing vertebrae as compared to conventional craniospinal radiation. However, the long-term effects of tomotherapy dose avoidance on spine growth and large volume low dose radiation in children are not yet known.

Discovering the nature of sacral orientation is of considerable anthropological importance. Therefore, this study aims at presenting a new anthropologically based definition for sacral anatomical orientation (SAO) angle, establishing standards of SAO for human population; examining the relationship between pelvic incidence (PI) and SAO; and associating SAO with demographic parameters. The study population consisted of 424 adult and 14 sub-adult (13–18 years, for SAO only) pelvises. Sacral orientation was measured using two different definitions: a) SAO is the angle created between the intersection of a line running parallel to the superior surface of the sacrum and a line running between the anterior superior iliac spine (ASIS) and the anterior-superior edge of the symphysis pubis; b) PI is the angle created between the perpendicular to the sacral plate at its midpoint and the line connecting this point to the middle of the axis of the acetabulum. SAO was measured using a specially designed mechanical measurement tool and a 3D digitizer. PI was measured via the 3D digitizer. The methods developed by us for measuring SAO and PI in skeletal material are valid and reliable. SAO and PI measures were highly correlated (r = −0.824, P < 0.001). The average SAO was 49.01° (SD = 10.16), and the average PI 54.08° (SD = 12.64). SAO was independent of ethnicity and sex, yet age dependent. This study establishes a methodology for estimating SAO and PI in skeletal material and furnishes the anthropological milieu with base line data regarding these parameters. Future studies in human evolution can greatly benefit from this study. Am J Phys Anthropol, 2007. © 2007 Wiley-Liss, Inc.

STUDY DESIGN Spondylolytic defects at L5 are influenced by insufficient differential spacing between the inferior articular facets of L4 and superior facets of S1. These structures then impinge on the intervening L5 pars interarticularis during hyperlordosis, contributing to fracture and resorption of the pars. OBJECTIVES Articular facet spacing was evaluated on clinical radiographs of normal and spondylolytic patients. SUMMARY OF BACKGROUND DATA Spondylolysis ranges from a hairline fracture through the pars to a complete pseudarthrotic defect. Insufficient increase in the distance between articular facets from L4-L5 to L5-S1 has been associated with chronic lytic defects in a skeletal sample. METHODS Anteroposterior radiographs of 39 patients with L5-S1 spondylolysis were compared with radiographs from 42 normal individuals. Differences in transverse distances between lumbar articular facets and pedicles were compared using 2-tailed t tests. RESULTS Patients with spondylolysis exhibited a smaller increase in interfacet distance from the L3-L4 facet joints to the L5-S1 joints than do normal patients, even relative to vertebral size. CONCLUSIONS Spondylolytic fractures at L5 are influenced by an inadequate increase in interfacet distances between adjacent vertebrae. Individuals lacking sufficient increase in lower lumbar transverse interfacet dimensions are at greater risk of developing and maintaining spondylolytic defects.

The Woranso-Mille paleontological study area is located in the central Afar region of Ethiopia, about 360 km northeast of the capital, Addis Ababa. Some parts of this area have been paleontologically known since the 1970s. However, most of the fossiliferous areas were discovered by surveys conducted in the region between 2002 and 2004. By the end of the 2006 field season, a total of 17 vertebrate localities had been designated, and more than 1000 vertebrate fossil specimens collected. Among these specimens, there are more than 20 fossil hominid craniodental and postcranial remains, including one partial skeleton, of Pliocene age (3.5–3.8 Ma). Research at this study area has thus far focused on the geology and paleontology of the early Pliocene deposits along the Mille river and adjacent areas located between the towns of Mille and Chifra. Exposed sediments in the new fossiliferous area are mostly silty sand and silty clay horizons interbedded with a number of volcanic tuffs and basaltic flows suitable for 40Ar/39Ar radioisotopic dating. The total stratigraphic section is about 50 m thick with a minimum age of ~3.5 Ma. The study area also has deposits of early to middle Pleistocene age, although no locality has been designated to date. The new Woranso-Mille paleontological study area provides a crucial temporal window into the time during which Australopithecus anamensis (3.9–4.2 Ma) appears to have given rise to Australopithecus afarensis (3.0–3.6 Ma). Radiometric dates have thus far yielded a minimum age of 3.5 Ma for the hominid localities and this conforms well with a biochronological age estimate of 3.6–3.8 Ma. The associated fauna, particularly the abundance of fossil cercopithecids and presence of diverse aquatic fossil vertebrates, indicates a relatively closed, wooded habitat probably associated with a paleo-Mille river.

Ribs are naturally fragile and, as a consequence, are rarely preserved in the fossil record. The costal elements recovered from the KSD-VP-1/1 partial skeleton are important evidence allowing reconstruction of the hominin thoracic cage. The ribs of KSD-VP-1/1 are examined with respect to their implications for the evolution of Australopithecus afarensis thoracic morphology. Angulation and torsion along the rib corpus and rib declination indicate a broad upper thorax and a deeply invaginated thoracic vertebral column. Implications for the early hominin thoracic bauplan are discussed.

KSD-VP-1/1 is a 3.6 million years old (Ma) partial skeleton of Australopithecus afarensis recently discovered from the Woranso-Mille study area in the Afar region of Ethiopia. The recovered elements of this specimen, which include cervical vertebrae, a complete scapula, clavicle, numerous ribs, pelvis, and elements of the fore- and hindlimbs, greatly enhance our understanding of the paleobiology of early Australopithecus afarensis. Detailed analyses of the cervical vertebrae indicate that Australopithecus afarensis had a highly mobile neck, signaling human-like kinematics consistent with habitual upright posture and bipedalism. Elements of the shoulder girdle exhibit some primitive morphology but are overall more similar to humans than has been previously understood. This similarity is inconsistent with the notion that the Australopithecus afarensis shoulder retained primitive morphology from an African ape-like chimpanzee/human last common ancestor. Morphology of the thorax also indicates that while some individual traits may appear to superficially suggest arboreality, Australopithecus afarensis did not have an abundance of functionally significant morphological traits that would suggest high canopy arboreality as found today in large-bodied apes. Most of the inconsistencies in interpretations of early hominin paleobiology appear to stem from methodological differences, incorrect a priori assumptions, or incomplete information derived from fragmentary specimens.

The pelvis and limb bones of KSD-VP-1/1 are analyzed with respect to their implications for the history of morphology, gait pattern, and bauplan of Australopithecus afarensis . The pelvis is essentially of modern aspect, and differs little from that of modern humans save in a few minor respects, such as, for example, size of the auricular surface and acetabulum. Its ischial conformation is the direct evidence of a strong history of dynamic running in its immediate ancestors, and its general shape confirms the overall Australopithecus pattern of platypelloidy. The implications with respect to the history of the hominin bauplan are discussed, as are those impacted by recent developments in our understanding of developmental biology. These are reviewed in light of other recent analyses of early hominin morphology and locomotion.

The Upper Palaeolithic of the Levant (45 000–22 000 BP) represents the full establishment of modern human behavior in this region following the existence of both modern humans and Neanderthals during the Middle Palaeolithic. The Levantine Upper Palaeolithic shares some similarities to its European counterpart but otherwise is quite different.

A key event in human evolution is the expansion of modern humans of African origin across Eurasia between 60 and 40 thousand years (kyr) before present (bp), replacing all other forms of hominins. Owing to the scarcity of human fossils from this period, these ancestors of all present-day non-African modern populations remain largely enigmatic. Here we describe a partial calvaria, recently discovered at Manot Cave (Western Galilee, Israel) and dated to 54.7 ± 5.5 kyr bp (arithmetic mean ± 2 standard deviations) by uranium-thorium dating, that sheds light on this crucial event. The overall shape and discrete morphological features of the Manot 1 calvaria demonstrate that this partial skull is unequivocally modern. It is similar in shape to recent African skulls as well as to European skulls from the Upper Palaeolithic period, but different from most other early anatomically modern humans in the Levant. This suggests that the Manot people could be closely related to the first modern humans who later successfully colonized Europe. Thus, the anatomical features used to support the 'assimilation model' in Europe might not have been inherited from European Neanderthals, but rather from earlier Levantine populations. Moreover, at present, Manot 1 is the only modern human specimen to provide evidence that during the Middle to Upper Palaeolithic interface, both modern humans and Neanderthals contemporaneously inhabited the southern Levant, close in time to the likely interbreeding event with Neanderthals.

STUDY DESIGN Morphometric analysis of anatomic scoliotic specimens. OBJECTIVE The objective of this study was to identify a typical deformation pattern for thoracic and lumbar vertebrae in idiopathic scoliosis. SUMMARY OF BACKGROUND DATA Idiopathic scoliosis is a three-dimensional deformity affecting the orientation and position of the spine in space. The regional deformity has been studied extensively, but most of the knowledge we currently have regarding the local deformity is the result of isolated observations made on rare scoliotic specimens with severe deformities. MATERIALS AND METHODS Thirty scoliotic specimens from two major osteologic sources were studied using a three-dimensional digitizing protocol developed by our research group creating a precise three-dimensional reconstruction of the vertebrae. Parameters were then calculated for each vertebra from these reconstructions. Every scoliotic specimen was then matched with a normal specimen to provide for a representative control group. RESULTS A total of 984 vertebrae (472 scoliotic and 512 normal vertebrae) were measured, creating the largest database of normal and scoliotic vertebral specimens. A characteristic deformity pattern was identified consisting of progressive vertebral wedging, decreased pedicle width on the concave side of the curve, and articular facet surface varying greatly with all findings increasingly more important toward the apex of the curve and as curve severity increased. All findings were statistically significant with P< 0.05. CONCLUSION These results are of critical importance for the understanding of the local and regional deformity and in understanding curve progression. Our results also advocate caution in the use of pedicle screws in the thoracic spine, especially on the concave side of the curve.

This paper describes a phenomenon in the endocranial plate, which we have termed “serpens endocrania symmetrica” (SES), and discusses its value as a diagnostic tool. The affected discolored bone area exhibits disruption of the endocranial surface, lending it a maze-like appearance. Histological sections demonstrate that the process is limited to the most superficial portion of the endocranium, with no diploic and ectocranial involvement (sinus areas excepted). Adult skulls (n = 1,884) from the Hamann-Todd collection (HTH), housed at the Cleveland Museum of Natural History, were utilized for the present study. SES was recognized in 32 of the 1,884 skulls studied (1.7%). The frequency of SES among individuals reported to have died from tuberculosis (TB) was 4.4%. The rate of SES in the non-TB sample was only 0.53%. The locations were as follows: limited to sinus area, 28.1%; calvarium (excluding the sinuses), 46.9%; sinus + calvarium, 25.0%. SES was bilateral in 90.9% of cases. Twenty-five of the 32 individuals (78.1%) with SES in the HTH collection had tuberculosis specifically listed as the cause of death. Six of the other 7 individuals had infections other than TB. In 29 of the 32 individuals with SES, infection involved structures within the thorax. As SES was also associated with another osteological phenomenon known to represent pulmonary disease, i.e., hypertrophic osteoarthropathy (HOA; 68.0% of SES individuals also had HOA), SES may be of diagnostic value in paleopathology for the recognition of intrathoracic disease, and perhaps tuberculosis. Am J Phys Anthropol 118:201–216, 2002. © 2002 Wiley-Liss, Inc.

Objectives This study examines the relationship between spheno-occipital synchondrosis (SOS) closure and puberty onset in a modern American population. It also investigates the timing and the rate of SOS closure in males and females. Materials and methods The sample includes cross-sectional and longitudinal 3D Cone Beam Computed Tomography (CBCT) scans of 741 individuals (361 males and 380 females) aged 6–20 years. Each CBCT scan is visualized in the mid-sagittal plane, and the spheno-occipital synchondrosis (SOS) is scored as completely open, partially fused, mostly fused, and completely fused. The Menarche commencement is used as an indicator of puberty onset in females. Results Mean ages of open, partially-fused, mostly-fused, and completely fused SOS were 11.07, 12.95, 14.44, and 16.41 years in males, and 9.75, 11.67, 13.25, and 15.25 in females, respectively. The results show there is a significant association between the SOS closure stage and the commencement of menarche (Fisher's Exact Test p < 0.001). It was found that females had a higher SOS closure rate (38.60%) per year than males at the age of 10 years. The closure rate in males appears slower than females at age 10, but it lasts a longer time, ranging between 22 and 26% per year from age 11 to 14 years. Conclusion There is a significant relationship between puberty onset and SOS closure, suggesting its closure is at least partially affected by systemic, hormonal changes in the growing adolescent. Also, SOS closure occurs at a faster rate and at an earlier age in females compared to males.

Among living mammals, only the African apes and some anteaters adopt knuckle-walking as their primary locomotor behavior. That Pan and Gorilla both knuckle-walk has been cited as evidence of their common ancestry and a primitive condition for a combined Homo, Pan, and Gorilla clade. Recent research on forelimb ontogeny and anatomy, in addition to recently described hominin fossils, indicate that knuckle-walking was independently acquired after divergence of the Pan and Gorilla lineages. Although the large-bodied, largely suspensory orangutan shares some aspects of the African ape bauplan, it does not regularly knuckle-walk when terrestrial. While many anatomical correlates of knuckle-walking have been identified, a functional explanation of this unusual locomotor pattern has yet to be proposed. Here, we argue that it was adopted by African apes as a means of ameliorating the consequences of repetitive impact loadings on the soft and hard tissues of the forelimb by employing isometric and/or eccentric contraction of antebrachial musculature during terrestrial locomotion. Evidence of this adaptation can be found in the differential size and fiber geometry of the forearm musculature, and differences in torso shape between the knuckle-walking and non-knuckle-walking apes (including humans). We also argue that some osteological features of the carpus and metacarpus that have been identified as adaptations to knuckle-walking are consequences of cartilage remodeling during ontogeny rather than traits limiting motion in the hand and wrist. An understanding of the functional basis of knuckle-walking provides an explanation of the locomotor parallelisms in modern Pan and Gorilla. Anat Rec, 301:496-514, 2018. © 2018 Wiley Periodicals, Inc.

The authors studied 37 presumed calcaneonavicular tarsal coalitions from the Hamann-Todd Osteological Collection at the Cleveland Museum of Natural History. The anatomy of the coalitions and the associated subtalar and transverse tarsal joints was quite variable. The coalitions in 8 specimens completely spared the anterior facet of the calcaneus and in 7 specimens it was partially replaced by the navicular portion of the coalition, whereas in 22 specimens the anterior calcaneal facet was completely replaced by the navicular portion of the coalition. The authors suggest that the pathoanatomy of calcaneonavicular coalitions is not uniform and may involve the subtalar and transverse tarsal joints. This may have clinical relevance and contribute to the unsatisfactory results in feet undergoing coalition resection and soft tissue interposition.

Hyperostosis frontalis interna (HFI) is manifested by the accretion of bone on the inner table of the frontal bone. Despite the vast literature on HFI, ambiguity exists as to its etiology, osteogenesis, demography, and history. This stimulated the present broad-scale study of HFI which included the evaluation of 1,706 early 20th century skulls (1,007 males and 699 females) from the Hamann-Todd and Terry human osteological collections, as well as 2,019 pre-19th century East-Mediterranean, Amerindian, and Central European skulls. In addition, 72 cadavers were dissected for gross inspection and histology. Special attention was paid to the relationship of the brain and meninges to endocranial lesions. HFI is an independent condition, not a symptom of a more generalized syndrome as suggested in the past. It can appear in a variety of forms but each is the result of the same process and probably of the same etiology. Investigators' previous failure to recognize the mild stages of HFI (types A and B) as an early form of the general HFI process led to erroneous statistics and interpretations of observations. HFI should also be considered a phenomenon separate from HCI, hyperostosis cranialis diffusa (HCD), and other endostoses, even when it appears in association with them. To avoid ambiguity and facilitate the description of cranial hyperostoses, uniform nomenclature (HFI, HCD) has been recommended. HFI is rarely seen in historic populations, regardless of geographical origin. It is most commonly found among females and is believed to be associated with prolonged estrogen stimulation. While its magnitude of manifestation and frequency are much higher in females, HFI is not a purely female phenomenon. Males with hormonal disturbances such as atrophic testis were found to manifest HFI type D. HFI is associated with age insofar as it is much less frequent in females under 40 years of age. Although advanced cases of HFI (types C and D) have been observed in individuals as young as 40 years of age, it is more frequently found after age 60. The frequency of HFI type D will not increase from age 60. Type-predicted analysis by cohort reveals significant ethnic differences. Changes in African American (AA) females appear earlier in life and progress more rapidly than in European American (EA) females. Analysis of radiographs shows a discrepancy between the anatomic prevalence of HFI and its radiological recognition, which is very poor for mild cases. This apparently resulted in the misconceptions that HFI is entirely an old-age phenomenon, and that it is exclusively female. Histological analysis shows that the inner table along with the closely attached dural layer play a major role in the osteogenesis of HFI. Contrary to previous models, no evidence for diploe or ectocranial plate involvement was found. Cadaver study suggests that the predilection for the frontal area may be related to an altered blood supply and/or vascular stretching.

The lack of an adequate hominid fossil record in eastern Africa between 2 and 3 million years ago (Ma) has hampered investigations of early hominid phylogeny. Discovery of 2.5 Ma hominid cranial and dental remains from the Hata beds of Ethiopia's Middle Awash allows recognition of a new species of Australopithecus . This species is descended from Australopithecus afarensis and is a candidate ancestor for early Homo . Contemporary postcranial remains feature a derived humanlike humeral/femoral ratio and an apelike upper arm–to–lower arm ratio.

Diploic veins (Canales diploicae), which were identified in dogs by Dupuytren more than 200 years ago (Hecker [1845] Die anatomische Verhaltnisse und Krankheiten der Venae diploicae und Vasa emissaria. Erfahrungen und Abhandlungen im Gebiete der Chirurgie und Augenheilkunde. Erlangen), have remained inadequately understood and scantily referenced in the anatomical and anthropological literature. The tunnels formed by diploic veins are among the few known skeletal markers of soft tissue alteration. Protected by two bony laminae, diploic vein tunnels often resist postdepositional destruction and may provide a new way to assess living and extinct hominid populations. This basic research was carried out to enable future utilization of the diploic venous channels in anthropologic research. In the present study, diploic venous channels were observed radiographically in 108 human adults aged 19 years and above, 18 infants and children aged 1–18 years (Hamann-Todd Osteological Collection), eight fetuses aged 7–9 months (the Johns Hopkins Collection), and seven nonhuman primates (Hamann-Todd Osteological Collection). In addition, seven documented cases of parents and children were radiographed for genetic evaluation (Osteological Collection of The Hungarian Natural History Museum). Five distinct diploic distribution patterns were identified and described in this study. This was at variance with the impressions reported in dissection-based studies. Independence of diploic vein pattern from demographic (gender and age) and size factors and their tendency to be symmetrical make them amenable and reliable traits for skeletal population study. Diploic vein patterns appeared to be more complicated in humans than in nonhuman primates, raising the possibility of future phylogenetic applications. Am J Phys Anthropol 108:345–358, 1999. © 1999 Wiley-Liss, Inc.

Resume La ≪ flexion ≫ de la base du crâne humain est habituellement utilisee en anthropologie comme parametre phylogenetique et discutee dans les travaux portant sur les capacites de langage articule des Hominides. La variation de ce caractere morphologique est cependant peu connue chez l'homme anatomiquement moderne, en dehors de ses modifications au cours de la croissance. Pour apprecier cette variation chez l'homme actuel, nous avons realise une mesure directe de l'angle sphenoidal sur un echantillon de 330 crânes humains de sexe, d'âge et d'ethnie connus. Notre etude a permis de mettre en evidence sur l'echantillon adulte que l'âge est un parametre determinant dans la variation de cet angle, les sujets les plus âges ayant un angle plus ferme que les sujets plus jeunes. Il s'agit de la premiere mise en evidence de l'existence de modifications sensibles au cours-du vieillissement squelettique de l'anatomie de la base du crâne chez Homo sapiens sapiens. Cette variation pourrait permettre l'utilisation en anthropologie de ce parametre comme nouvel indicateur d'âge chez le sujet adulte.

The present study discusses in detail the osteological changes associated with sickle cell anemia in children and their importance in differential diagnosis. Posterior calcaneal and specific articular surface disruptive metacarpal lesions are diagnostic for sickle cell anemia. Calvarial thickening, tibial and femoral cortical bone thickening, and bowing are of more limited utility in differential diagnosis. Granular osteoporosis, pelvic demineralization and rib broadening are nonspecific. Localized calvarial “ballooning,” previously not described, may have diagnostic significance. Bone marrow hyperplastic response (porotic hyperostosis) in sickle cell anemia produces minimal radiologic changes contrasted with that observed in thalassemia and blood loss/hemolytic phenomenon. Two other issues, the osteological criteria for discriminating among the anemias and the purported relationship between porotic hyperostosis and iron deficiency anemia, are also discussed. There is sufficient information to properly diagnose the four major groups of anemias, and further, to establish that iron deficiency is only indirectly associated with porotic hyperostosis. The hyperproliferative bone marrow response (manifest as porotic hyperostosis) to blood loss or hemolysis exhausts iron stores, resulting in secondary iron deficiency. Am J Phys Anthropol 104:213–226, 1997. © 1997 Wiley-Liss, Inc.

We examined the femora of 2665 adult human skeletons from an osteological collection to determine the prevalence of post-slip morphology termed femoral head-tilt deformity by Murray and pistol-grip deformity by Stulberg et al. The hypothesis was that primary osteoarthrosis of the hip is a secondary manifestation of a subclinical developmental disorder of the hip. The prevalence of post-slip morphology was 8 per cent (215 of 2665 skeletons). Severe osteoarthrosis was more prevalent in association with post-slip morphology (116 [38 per cent] of 306 hips) than in the matched controls (seventy-nine [26 per cent] of 306 hips) (p < 0.005). In the skeletons that had unilateral post-slip morphology, severe osteoarthrosis was more prevalent in the involved hips (thirty-one [37 per cent] of eighty-three) than in the contralateral, normal hips (eighteen [22 per cent] of eighty-three) (p < 0.05). Post-slip morphology, which was unrelated to age, was found to be a major risk factor for the development of high-grade osteoarthrosis. We noted evidence of high-grade osteoarthrosis in sixty-three (68 per cent) of the ninety-three hips with minimum post-slip morphology in skeletons from individuals who had been fifty-six years old or more at the time of death compared with forty-five (48 per cent) of the ninety-three control hips. With the numbers available, this difference was not found to be significant (p < 0.025). The osteoarthrosis in the hips with post-slip morphology was distinctly characterized by anterior flattening of the acetabulum, cystic degeneration in the anterior metaphyseal-epiphyseal region, and progression to global osteoarthrosis of the hip.

Contiguous high resolution computed tomography images were obtained at a 1.5 mm slice thickness perpendicular to the neck axis from the base of the femoral head to the trochanteric line in a sample of 10 specimens each of Homo sapiens, Pan troglodytes, and Gorilla gorilla, plus five specimens of Pan paniscus. Superior, inferior, anterior, and posterior cortical thicknesses were automatically measured directly from these digital images. Throughout the femoral neck H. sapiens displays thin superior cortical bone and inferior cortical bone that thickens distally. In marked contrast, cortical bone in the femoral neck of African apes is more uniformly thick in all directions, with even greater thickening of the superior cortical bone distally. Because the femoral neck acts as a cantilevered beam, its anchorage at the neck-shaft junction is subjected to the highest bending stresses and is the most biomechanically relevant region to inspect for response to strain. As evinced by A.L. 128-1, A.L. 211-1 and MAK-VP-1/1, Australopithecus afarensis is indistinguishable from H. sapiens, but markedly different from African apes in cortical bone distribution at the femoral neck-shaft junction. Cortical distribution in the African ape indicates much greater variation in loading conditions consistent with their more varied locomotor repertoire. Cortical distribution in hominids is a response to the more stereotypic loading pattern imposed by habitual bipedality, and thin superior cortex in A. afarensis confirms the absence of a significant arboreal component in its locomotor repertoire.

The controversy over the reliability of ectocranial suture status (open vs. closed) as an age estimation stimulated the pursuit of Meindl and Lovejoy's suggestion (Meindl and Lovejoy [1985] Am. J. Phys. Anthropol. 68:57-66) for large scale analysis. The extent of the sagittal suture closure was assessed in 3,636 skulls from the Hamann-Todd and Terry collections. The debate over whether cranial suture ossification represents a pathologic or an age-predictable pathologic process also stimulated a comparison with age and two stress markers, hyperostosis frontalis interna and tuberculosis. Sagittal suture closure was found to be age-independent and sexually biased. The wide confidence intervals (for age) appear to preclude meaningful application of suture status for age determination. No correlation was found with the tested biological stressors.

In the present study, 1,869 skulls from the Hamann-Todd Collection were examined (macroscopically and by radiographs) for closure of the petroexoccipital articulation (jugular synchondrosis). The results demonstrated that the petroexoccipital articulation underwent closure between 20 and 50 years of age in most of the human skulls evaluated. Approximately 7–10% of the human skulls underwent complete union of the petroexoccipital articulation before 20 years of age. In 5–9% of the population, the joint remained completely open. After 50 years of age, there was no increase in the frequency of individuals with complete closure. The frequency of “partial closure” was similar (4–8%) for all age groups (20–25, 30–35, 40–45, 50–55, 60–65, and 70+), excluding the 30–35 year old group (17.5%). The time interval necessary for closure to occur appeared to be very short. No significant differences in closure rates due to ethnic origin, gender, or laterality were noted. The utility of the petroexoccipital articulation as an age estimator is discussed. Am J Phys Anthropol 103:365–373, 1997. © 1997 Wiley-Liss, Inc.

Recognition of disease in the archeologic record is facilitated by characterization of the skeletal impact of documented (in life) disease. The present study describes the osteological manifestations of leukemia as identified in the skeletons of two individuals diagnosed during life: a 3-year-old black girl with acute lymphocytic leukemia and a 60-year-old white male with acute myelogenous leukemia in the Hamann-Todd collection. Contrasting with the lack of specificity of radiologic findings, macroscopic skeletal changes appear sufficiently specific to allow distinguishing leukemia from other forms of cancer. While leukemia appears confidently diagnosable, distinguishing among the varieties (e.g., myelogenous and lymphocytic) does not appear possible at this time. Skeletal findings in leukemia are presented in tabular form to facilitate their application to future diagnosis of the disease in the archaeological record.

The opportunity to examine the defleshed skeleton of an individual diagnosed in life (Hamann-Todd collection, individual 2036) afforded a unique opportunity to demonstrate the bone damage characteristic of at least one form of juvenile rheumatoid arthritis (JRA). Characteristics helpful for recognition of JRA in archaeological material include peripheral articular marginal and subchondral erosions, axial (e.g., zygapophyseal or sacroiliac) joint erosions, fusion of axial (cervical zygapophyseal) and/or peripheral joints, premature epiphyseal closure and/or ballooned epiphyses, growth retardation with underdeveloped (short and overtubulated) long bones, short mandibular rami with underdeveloped condyles and concomitant micrognathia, and demineralization (osteopenia). Distinguishing between JRA and juvenile spondyloarthropathy, however, is not always possible, as illustrated by this case.

The literature abounds with conflicting data on various morphometric aspects of the temporomandibular joint (TMJ). The purpose of this study was to observe the effects of sex, ethnic group, and edentulism on TMJ osseous morphology and to define possible factors which might influence variation in this structure. TMJs and related craniofacial structures were measured directly on 229 dry skulls and matching mandibles. Analysis of variance, principal component analysis, and cluster analysis were performed. Our results indicate that 1) the anteroposterior-related TMJ dimensions are independent of sex, ethnic group, and edentulism; 2) the transverse TMJ dimension is related to cranial breadth measures; and 3) the projected distance, along a midsagittal plane, between the TMJ and foramen magnum is independent of sex, ethnicity, and edentulism. It is our assertion that the TMJ must not be considered as a single morphological structure but rather viewed as a functional unit with component parts which are subordinate to completely different sets of influences.

Two complete skeletons from the Hamman-Todd collection of the Cleveland Museum of Natural History (CMNH) show a suite of pathological lesions that suggest the individuals had been involved in boxing or other hand-to-hand combat. These lesions were studied and compared with medical and autopsy records. The aims of the research were to estimate the accumulated damage to the bones over time, to characterize the different types of the damage, and to establish criteria for hand-to-hand combat or violence for archaeological material. Our inspections showed that besides the muscle markings developed and the numerous healed fractures that are expected when someone is involved in such activities, other types of lesion are present that are helpful for a proper differential diagnosis. These are: degenerative changes at the lesser tuberosity of the humerus; focal necrotic changes/bone growth on the trochlea of the humerus; necrotic changes on the distal head of the ulna; bony patches on upper limb bones only; secondary centres of ossification failing to fuse (mainly in vertebrae and acromion); a huge conoid tubercle on the clavicle; bony spurs on the distal articular head of the metacarpals; necrotic changes on the femoral head next to the fovea and on the roof of the acetabulum; and a developed bony ridge for the attachment of the iliotrochanteric ligament.Finally, we propose a set of criteria that will help to identify people in archaeological material who were involved in hand-to-hand combat. Language: en

A newly discovered partial hominin foot skeleton from eastern Africa indicates the presence of more than one hominin locomotor adaptation at the beginning of the Late Pliocene epoch. Here we show that new pedal elements, dated to about 3.4 million years ago, belong to a species that does not match the contemporaneous Australopithecus afarensis in its morphology and inferred locomotor adaptations, but instead are more similar to the earlier Ardipithecus ramidus in possessing an opposable great toe. This not only indicates the presence of more than one hominin species at the beginning of the Late Pliocene of eastern Africa, but also indicates the persistence of a species with Ar. ramidus-like locomotor adaptation into the Late Pliocene.

Only one partial skeleton that includes both forelimb and hindlimb elements has been reported for Australopithecus afarensis . The diminutive size of this specimen (A.L. 288-1 ["Lucy"]) has hampered our understanding of the paleobiology of this species absent the potential impact of allometry. Here we describe a large-bodied (i.e., well within the range of living Homo ) specimen that, at 3.58 Ma, also substantially antedates A.L. 288–1. It provides fundamental evidence of limb proportions, thoracic form, and locomotor heritage in Australopithecus afarensis . Together, these characteristics further establish that bipedality in Australopithecus was highly evolved and that thoracic form differed substantially from that of either extant African ape.

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STUDY DESIGN Retrospective radiographic review. OBJECTIVE The purpose of this article was to explore the relationship between interfacet spacing and pediatric spondylolysis. SUMMARY OF BACKGROUND DATA Recent literature suggests that a potential cause of spondylolytic defects in adults is a narrowed interfacet spacing in the lower lumbar spine. This lack of space places them at increased risk for pars fractures with repetitive lumbar hyperextension. This relationship has not been explored in a pediatric population. METHODS The anteroposterior lumbar spine radiographs of 41 pediatric patients with spondylolytic defects were compared with 41 unaffected controls. A standard digital caliper was used to measure interfacet distance. Vertebral body width and interpedicular distance were recorded as internal standards to control for varying vertebral size. Statistical analysis exploring the relationships of interfacet distances between the affected and unaffected groups was performed using a Mann-Whitney U test. RESULTS The absolute increase in interfacet distance between adjacent levels was significantly smaller at the L4/L5 level in spondylolytic individuals (P = 0.023). When interpedicular distance was used to standardize for vertebral body size, a significantly smaller increase in the interpedicular distance was noted at the L4/5 level in spondylolytic individuals (P = 0.026). Similar results were obtained when body width was used to standardize for vertebral body size (P < 0.001). A similar trend was noticed at the L3/4 level when standardizing with interpedicular distance although these results were not significant (P = 0.098). CONCLUSION A likely explanation for the etiology of lumbar pars defects is insufficient caudal increase in lumbar interfacet spacing. Further prospective studies are necessary to determine if unaffected individuals with a narrowed interfacet spacing are at increased risk of developing spondylolytic defects later in life.

The phylogenetic relationship between Australopithecus anamensis and Australopithecus afar- ensis has been hypothesized as ancestor-descendant. However, the weakest part of this hypothesis has been the absence of fossil samples between 3.6 and 3.9 million years ago. Here we describe new fossil specimens from the Woranso-Mille site in Ethiopia that are directly rele- vant to this issue. They derive from sediments chrono- metrically dated to 3.57-3.8 million years ago. The new fossil specimens are largely isolated teeth, partial mandi- bles, and maxillae, and some postcranial fragments. However, they shed some light on the relationships between Au. anamensis and Au. afarensis. The dental morphology shows closer affinity with Au. anamensis from Allia Bay/Kanapoi (Kenya) and Asa Issie (Ethiopia) than with Au. afarensis from Hadar (Ethiopia). However, they are intermediate in dental and mandibular mor- phology between Au. anamensis and the older Au. afar- ensis material from Laetoli. The new fossils lend strong support to the hypothesized ancestor-descendant rela- tionship between these two early Australopithecus spe- cies. The Woranso-Mille hominids cannot be unequivo- cally assigned to either taxon due to their dental mor- phological intermediacy. This could be an indication that the Kanapoi, Allia Bay, and Asa Issie Au. anamensis is the primitive form of Au. afarensis at Hadar with the Laetoli and Woranso-Mille populations sampling a mosaic of morphological features from both ends. It is particularly difficult to draw a line between Au. anamen- sis and Au. afarensis in light of the new discoveries from Woranso-Mille. The morphology provides no evidence that Au. afarensis and Au. anamensis represent distinct taxa. Am J Phys Anthropol 141:406-417, 2010. V C 2009

Considerable differences in spinal morphology have been noted between humans and other hominoids. Although comparative analyses of the external morphology of vertebrae have been performed, much less is known regarding variations in internal morphology (density) and biomechanical performance among humans and closely related non-human primates. In the current study we utilize density calibrated computed tomography images of thoracic vertebral bodies from hominoids (n=8-15 per species, human specimens 20-40 years of age) to obtain estimates of vertebral bone strength in axial compression and anteroposterior bending and to determine how estimates of strength scale with animal body mass. Our biomechanical analysis suggests that the strength of thoracic vertebral bodies is related to body mass (M) through power law relationships (y proportional, variant M(b)) in which the exponent b is 0.89 (reduced major axis) for prediction of axial compressive strength and is equal to 1.89 (reduced major axis) for prediction of bending strength. No differences in the relationship between body mass and strength were observed among hominoids. However, thoracic vertebrae from humans were found to be disproportionately larger in terms of vertebral length (distance between cranial and caudal endplates) and overall vertebral body volume (p

Metatarsophalangeal joints from African pongids, modern humans, and Australopithecus afarensis are compared to investigate the anatomical and mechanical changes that accompanied the transition to terrestrial bipedality. Features analyzed include the shape and orientation of the metatarsal heads, excursion of the metatarsophalangeal joints, and orientation of the basal articular surface of the proximal phalanges. These features unequivocally segregate quadrupedal pongids and bipedal hominids and demonstrate a clear adaptation to terrestrial bipedality in the Hadar pedal skeleton.