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231 results on '"Bruder G"'

2. Guidelines for the welfare and use of animals in cancer research

Author

Workman, P, Aboagye, EO, Balkwill, F, Balmain, A, Bruder, G, Chaplin, DJ, Double, JA, Everitt, J, Farningham, DAH, Glennie, MJ, Kelland, LR, Robinson, V, Stratford, IJ, Tozer, GM, Watson, S, Wedge, SR, and Eccles, SA

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, 5.9 Resources and infrastructure (treatment development), 2.6 Resources and infrastructure (aetiology), Aetiology, Development of treatments and therapeutic interventions, Disputed aetiology and other, Algorithms, Animal Experimentation, Animal Welfare, Animals, Biomarkers, Pharmacological, Biomedical Research, Cell Line, Transformed, Diagnostic Imaging, Disease Models, Animal, Female, Humans, Male, Mice, Neoplasm Transplantation, Neoplasms, Practice Guidelines as Topic, Treatment Outcome, Xenograft Model Antitumor Assays, animal welfare, cancer research, fundamental and translational research, replacement, reduction and refinement, pilot studies, tumour models, genetically engineered mouse models, human tumour xenografts, orthotopic models, metastatic models, therapy, imaging, pharmocokinetic, pharmacodynamic and efficacy studies, drugs, radiation therapy, imaging techniques, anaesthesia, restraint, humane endpoints, tumour burden, clinical signs, publication, best practice, Committee of the National Cancer Research Institute, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.

Published
2010

5. A computational analysis of flanker interference in depression

Author

Dillon, D. G., Wiecki, T., Pechtel, P., Webb, C., Goer, F., Murray, L., Trivedi, M., Fava, M., McGrath, P. J., Weissman, M., Parsey, R., Kurian, B., Adams, P., Carmody, T., Weyandt, S., Shores-Wilson, K., Toups, M., McInnis, M., Oquendo, M. A., Cusin, C., Deldin, P., Bruder, G., and Pizzagalli, D. A.

Published
2015
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11. Guidelines for the welfare and use of animals in cancer research

Author

Workman, P., Aboagye, E. O., Balkwill, F., Balmain, A., Bruder, G., Chaplin, D. J., Double, J. A., Everitt, J., Farningham, D. A. H., Glennie, M. J., Kelland, L. R., Robinson, V., Stratford, I. J., Tozer, G. M., Watson, S., Wedge, S. R., Eccles, S. A., Navaratnam, V., Ryder, S., and Natl Canc Res Inst, NCRI

Abstract

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.

Published
2010

42. Perceptual asymmetries in schizophrenia: subtype differences in left hemisphere dominance for dichotic fused words.

Author

Friedman, Michelle S., Bruder, Gerard E., Nestor, Paul G., Stuart, Barbara K., Amador, Xavier F., Gorman, Jack M., Friedman, M S, Bruder, G E, Nestor, P G, Stuart, B K, Amador, X F, and Gorman, J M

Subjects
SCHIZOPHRENIA, CEREBRAL dominance, DICHOTIC listening tests, DIAGNOSIS of schizophrenia, AUDITORY perception, COMPARATIVE studies, DIFFERENTIAL diagnosis, RESEARCH methodology, MEDICAL cooperation, PSYCHOLOGICAL tests, RESEARCH, SEX distribution, EVALUATION research, SEVERITY of illness index
Abstract

Objective: Dichotic listening techniques have been used to study hemispheric dominance for language in schizophrenia. The authors' goal was to compare subjects with paranoid and undifferentiated subtypes of schizophrenia.Method: The Fused Rhymed Words Test was used to compare perceptual asymmetries in 16 patients with paranoid schizophrenia, 28 patients with undifferentiated schizophrenia, and 29 healthy comparison subjects.Results: Patients with paranoid schizophrenia had the largest left hemisphere advantage and patients with undifferentiated schizophrenia had the smallest. The asymmetry of healthy subjects was intermediate. Hemisphere advantage varied as a function of gender only in the patients with undifferentiated schizophrenia.Conclusions: The findings support the hypotheses that undifferentiated schizophrenia is associated with underactivation of left hemisphere resources for verbal processing and that paranoid schizophrenia is characterized by preserved left hemisphere processing. [ABSTRACT FROM AUTHOR]

Published
2001
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43. Dichotic perception: evidence for right hemisphere dysfunction in affective psychosis.

Author

Yozawitz, Allan, Bruder, Gerard, Sutton, Samuel, Sharpe, Lawrence, Gurland, Barry, Fleiss, Joseph, Costa, Louis, Yozawitz, A, Bruder, G, Sutton, S, Sharpe, L, Gurland, B, Fleiss, J, and Costa, L

Subjects
PSYCHOSES, PATHOLOGICAL psychology, PEOPLE with schizophrenia, PEOPLE with mental illness, SCHIZOPHRENIA, HEARING disorders, PSYCHIATRIC diagnosis, PSYCHIATRIC treatment, PSYCHIATRY, AUDITORY perception, BRAIN, CEREBRAL dominance, COMPARATIVE studies, DICHOTIC listening tests, BIPOLAR disorder, RESEARCH methodology, MEDICAL cooperation, RESEARCH, EVALUATION research
Abstract

The association between lateralized hemispheric dysfunction and psychiatric diagnosis was investigated with a measure of summation of dichotic clicks and with a dichotic competing message task. Ear asymmetries of affective psychotic patients were similar to those of right temporal lesioned controls and differed from those of schizophrenic patients and normal controls. In contrast, schizophrenic patients did not display abnormal auditory perceptual asymmetries. [ABSTRACT FROM AUTHOR]

Published
1979
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50. Woman aviator.

Author

Bruder, G.

Subjects
EARHART, Amelia, 1897-1937
Abstract

Details the enduring mystery of Amelia Earhart, America's premier woman aviator, 50 years after her still-unsolved 1937 disappearance in the South Pacific during her attempted round-the-world flight with navigator Fred Noonan. Profiles Earhart's life and career; Last flight and disappearance; Searches; Theories as to their fate. INSET: Reading list on Earhart's disappearance..

Published
1987

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