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46 results on '"Brumfiel, Caitlin M."'

3. Cutaneous B cell pseudolymphoma treated with rituximab and methotrexate

Author

Besch-Stokes, Jake G, Patel, Meera H, Brumfiel, Caitlin M, Costello, Collin M, Rule, William, Rosenthal, Allison, Pittelkow, Mark R, DiCaudo, David J, and Mangold, Aaron R

Subjects
B cell disorders, methotrexate, pseudolymphoma, rituximab
Abstract

Cutaneous B cell pseudolymphoma (CBPL), or cutaneous lymphoid hyperplasia, is the most common pseudolymphoma. It typically responds well to local treatment and follows a benign course. Herein, we describe the unique case of a patient with CBPL that was refractory to a variety of treatments, with subsequent response to rituximab followed by methotrexate. This case explores the complex interplay of T and B lymphocytes, and the potential role of perifollicular T cells in treatment resistant CBPL. Further, it describes the additive therapeutic effect of rituximab and methotrexate to target both B cell and T cell populations in CBPL, a strategy already employed in a number of other conditions.

Published
2021

6. How to Sequence Therapies in Mycosis Fungoides

Author

Brumfiel, Caitlin M., Patel, Meera H., Puri, Pranav, Besch-Stokes, Jake, Lester, Scott, Rule, William G., Khera, Nandita, Sluzevich, Jason C., DiCaudo, David J., Comfere, Nneka, Bennani, N. Nora, Rosenthal, Allison C., Pittelkow, Mark R., and Mangold, Aaron R.

Published
2021
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8. Necrobiosis lipoidica-associated cutaneous malignancy

Author

Harvey, Jamison A., primary, Severson, Kevin J., additional, Brumfiel, Caitlin M., additional, Patel, Meera H., additional, Butterfield, Richard J., additional, Nelson, Steven A., additional, Sekulic, Aleksandar, additional, Pittelkow, Mark R., additional, and Mangold, Aaron R., additional

Published
2022
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10. Skin Cancer Knowledge, Attitudes and Sun Protection Practices in the Hispanic Population: A Cross-Sectional Survey

Author

Besch-Stokes, Jake, primary, Brumfiel, Caitlin M., additional, Patel, Meera H., additional, Harvey, Jamison, additional, Montoya, Jordan, additional, Severson, Kevin J., additional, Cumsky, Helen, additional, Buras, Matthew, additional, Fagoaga, J. Eduardo González, additional, Costello, Collin M., additional, Pittelkow, Mark R., additional, and Mangold, Aaron R., additional

Published
2022
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11. Histopathologic features of necrobiosis lipoidica

Author

Johnson, Emma, primary, Patel, Meera H., additional, Brumfiel, Caitlin M., additional, Severson, Kevin J., additional, Bhullar, Puneet, additional, Boudreaux, Blake, additional, Butterfield, Richard J., additional, DiCaudo, David J., additional, Nelson, Steven A., additional, Pittelkow, Mark R., additional, and Mangold, Aaron R., additional

Published
2022
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16. Assessing the Safety and Efficacy of Trifarotene in the Treatment of Acne Vulgaris

Author

Brumfiel,Caitlin M, Patel,Meera H, Bell,Katheryn A, and Cardis,Michael A

Subjects
Therapeutics and Clinical Risk Management
Abstract

Caitlin M Brumfiel,1 Meera H Patel,2 Katheryn A Bell,1 Michael A Cardis3 1Georgetown University School of Medicine, Washington, DC, USA; 2Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, AZ, USA; 3MedStar Washington Hospital Center/Georgetown University Hospital Department of Dermatology, Washington, DC, USACorrespondence: Caitlin M BrumfielGeorgetown University School of Medicine, 3900 Reservoir Road, Washington, DC, 20007, USATel +1 513-260-3948Email cmb373@georgetown.eduAbstract: Acne vulgaris is a common skin condition of the face and trunk that negatively impacts quality of life. Trifarotene is a new first-in-class fourth-generation topical retinoid that has been uniquely studied in the treatment of both facial and truncal acne. Through selective agonism of retinoic acid receptor (RAR)-gamma, the most predominant RAR isotype in the epidermis, trifarotene exerts more targeted, skin-specific effects than earlier generation retinoids. This narrative review summarizes all currently available literature regarding the use of trifarotene in acne vulgaris. We focus on efficacy, safety, and tolerability data and highlight quality of life outcomes and patient-reported satisfaction. Future clinical trials and the clinical applicability of this novel medication in the treatment of acne are also discussed.Keywords: acne vulgaris, trifarotene, retinoid, randomized controlled trials

Published
2021

18. 26941 The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma in a random sampling representative of the general population

Author

Mangold, Aaron R., primary, Patel, Meera H., additional, Brumfiel, Caitlin M., additional, Severson, Kevin J., additional, Butterfield, Richard J., additional, Zhang, Nan, additional, Nelson, Steven A., additional, DiCaudo, David J., additional, Pittelkow, Mark R., additional, and Sekulic, Aleksander, additional

Published
2021
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25. Differences in Underrepresented in Medicine Applicant Backgrounds and Outcomes in the 2020-2021 Dermatology Residency Match.

Author

Rinderknecht, Fatuma-Ayaan, Brumfiel, Caitlin M., Jefferson, Itisha S., Worswick, Scott, and Rosman, Ilana S.

Subjects
RESIDENTS (Medicine), DERMATOLOGY, MEDICAL school admission
Abstract

The article reports that Dermatology is the least diverse medical specialties as studies addressing barriers faced by underrepresented in medicine (UIM) applicants to dermatology. Topics include process by dermatology residency programs may contribute to higher rates of matching among Black applicants; and disadvantaged backgrounds and to have financial concerns about the residency application process.

Published
2022
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35. Photodynamic Therapy in Refractory Mycosis Fungoides: A Prospective, Open-Label Study

Author

Brumfiel, Caitlin M, primary, Severson, Kevin J, additional, Patel, Meera H, additional, Cumsky, Helen J L, additional, Ginos, Brenda F, additional, Kosiorek, Heidi E., additional, Janeczek, Monica C, additional, Besch-Stokes, Jake, additional, Rule, William, additional, DiCaudo, David, additional, Rosenthal, Allison C., additional, Pittelkow, Mark R, additional, and Mangold, Aaron R, additional

Published
2020
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36. Comparative Transcriptomics of Alpha-Beta Subcutaneous Panniculitis-like T-Cell Lymphoma and Primary Cutaneous Gamma Delta T-Cell Lymphoma

Author

Li, Xing, primary, Severson, Kevin J, additional, Patel, Meera H, additional, Brumfiel, Caitlin M, additional, Hughes, Alysia, additional, DiCaudo, David, additional, Comfere, Nneka, additional, Sluzevich, Jason, additional, Rosenthal, Allison C., additional, Torres-Cabala, Carlos A, additional, Pittelkow, Mark R, additional, and Mangold, Aaron R, additional

Published
2020
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41. Consolidation of US dermatology practices.

Author

Puri, Pranav, Patel, Meera H., Brumfiel, Caitlin M., Pittelkow, Mark R., and Mangold, Aaron R.

Subjects
DERMATOLOGISTS, DERMATOLOGY, TAXPAYER account numbers
Abstract

Despite the increased consolidation over this time period, we estimate 26% of dermatologists were solo practitioners in 2020, and 65% of practices had only one dermatologist. Dear Editor, In recent years, health policy reforms, changes to payment models, and evolving market forces have presented new challenges to dermatology practices. Figure 1a shows that the proportion of dermatologists in solo practice or in groups with 2-5 dermatologists decreased from 66% in 2014 to 55% in 2020, while the proportion of dermatologists in larger groups increased from 34% to 45%. [Extracted from the article]

Published
2022
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43. Granulomatous Panniculitis as a Complication of Subcutaneous Testosterone Pellet Therapy.

Author

Patel MH, Brumfiel CM, Breen I, Glembocki D, and Luber A

Subjects
Male, Humans, Middle Aged, Subcutaneous Fat, Inflammation, Biopsy, Coloring Agents, Testosterone adverse effects, Panniculitis chemically induced
Abstract

A 51-year-old man with a 3-year history of exogenous testosterone pellet injections to the left buttock presented for routine skin examination. While the patient reported recurrent drainage from the site of testosterone replacement therapy (TRT) injections, he continued to receive repeated implantations every 6 months. On physical examination, a 12-mm irregular, brown macule was identified within a poorly demarcated, ecchymotic, and fluctuant subcutaneous plaque on the left buttock with a sinus tract draining serosanguinous fluid. The pigmented lesion was biopsied, revealing malignant melanoma in situ ; hence, a wide local excision was scheduled. During the procedure, necrotic subcutaneous fat was observed surrounding the site of biopsy, and a region measuring 18 cm 2 approximately was debrided and submitted for pathologic evaluation. Histopathologic examination revealed a diffused subcutaneous granulomatous infiltrate with septal and lobular panniculitis and fat necrosis as well as peripherally palisading histiocytes and hemosiderin deposition (Figures 1A and B). Similar findings were observed in another specimen from the same segment of debrided tissue, compatible with granulomatous panniculitis. Periodic acid-Schiff (PAS), Gram's, and acid-fast bacilli (AFB) stains revealed no microorganisms. During surgical exploration, six foreign bodies were discovered and identified as undissolved testosterone pellets. The patient was referred to a wound care center, but ultimately lost to follow-up.

Published
2023

45. Cutaneous Desmoplastic Leiomyosarcoma Development at Smallpox Vaccination Site.

Author

Patel MH, Brumfiel CM, Glembocki D, and Luber AJ

Subjects
Aged, 80 and over, Humans, Male, Vaccination, Leiomyosarcoma diagnosis, Melanoma, Skin Neoplasms diagnosis, Smallpox
Abstract

An 81-year-old man presented to the clinic with a 2.1 cm firm, skin-colored subcutaneous tumor on the left upper arm (Figure 1). The lesion arose at the site of a past smallpox vaccination and had been slowly enlarging for approximately 4 years. The differential diagnosis included sympastic leiomyoma, and a variety of desmoplastic spindle cell lesions such as desmoplastic melanoma, cutaneous spindle cell carcinoma, and desmoplastic leiomyosarcoma. Punch biopsy and immunohistochemical staining revealed positive spindle cells for desmin and caldesmon (Figures 2 and 3). Immunostain for p53 was also strongly and uniformly positive. Owing to poor circumscription on histopathology, symplastic leiomyosarcoma was ruled out. Demoplastic melanoma was also excluded due to positive immunoreaction to muscle markers (desmin and caldesmon) and negative S-100 staining. Additionally, cutaneous spinde cell carcinoma was also ruled out due to negative p63 and cytokeratin staining. Ultimately, clinicopathologic correlation favored a diagnosis of desmoplastic leiomyosarcoma. Staged excisions were performed to eradicate the lesion.

Published
2021

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