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Resumo A literatura sobre reformas eleitorais, em geral, e reformas do financiamento de campanhas, em específico, tem se beneficiado pouco das contribuições do campo de análise de políticas públicas. Seja em termos teóricos e/ou metodológicos. Este artigo propõe um modelo de análise de reformas do financiamento de campanhas a partir do conceito de ciclo de políticas (policy cycle), considerando como se forma a agenda sobre reformas (1); tomada de decisão (2); implementação (3); e avaliação (4). Utilizo este modelo para observar empiricamente o caso da regulação do autofinanciamento eleitoral no Brasil, a partir de métodos qualitativos e quantitativos. Os resultados indicam que a restrição do autofinanciamento no Brasil está associada ao maior peso desse tipo de recurso nas campanhas após a proibição das doações empresariais. E, também, a reforma parece não cumprir seus objetivos iniciais. Neste sentido, o artigo busca contribuir com a literatura em dois sentidos: a proposição de um modelo de análise das reformas de financiamento de campanhas e sua aplicação ao caso brasileiro.

Background/Objectives: Glioblastoma is a malignant tumor with a poor prognosis for the patient due to its high lethality and limited chemotherapy available. Therefore, from the point of view of chemotherapy treatment, glioblastoma can be considered an unmet medical need. This has led to the investigation of new drugs for monotherapy or associations, acting by synergistic pharmacological mechanisms. Methods: Here, we propose the combination of Osimertinib (a potent EGFR inhibitor) and Gedatolisib (a potent PI3K/mTOR dual inhibitor) through an in vitro phenotypic study using five human GB lines and establish the cytotoxic potency, selectivity, and effect on proliferation, apoptosis, and cell cycle by simultaneously inhibiting EGFR, PI3K, and mTOR. Results: Cytotoxic potency of Gedatolisib and Osimertinib in the selected GB cell lines was determined, which highlighted the synergistic response from their combination and its impact on migration reduction, G0/G1 cell cycle arrest, GB cytotoxicity, and apoptosis-inducing effects for different GB cell lines. Conclusions: From the drug combination studies in phenotypic in vitro models, it was possible to suggest a new potential treatment for glioblastoma that justifies further safe in vivo phases of preclinical trials with the combination.

Resumo Nesta nota técnica apresentamos um dos principais legados empíricos da pesquisa sobre propaganda das candidatas/dos candidatos a Deputado Federal do Estado do Rio de Janeiro no Horário Gratuito de Propaganda Eleitoral (HGPE) no período de 1998 a 2018. Trata-se de introduzir e descrever o processo de coleta dessa base de dados, os procedimentos utilizados ao longo do tempo para a sistematização das informações e os possíveis usos de dois bancos de dados vinculados à pesquisa: o primeiro possui como unidade de análise os programas eleitorais gravados no período; e, o segundo, possui como unidade de análise os/as candidatos/candidatas, contabilizando o tempo (em segundos) de aparição no HGPE; desempenho eleitoral de cada candidata/candidato (votos e resultado final); financiamento de campanha e outras características políticas, sociais e demográficas. O banco apresentado abarca nada menos do que 9.433 programas eleitorais gravados à noite, dos quais participaram 1.774 candidatos/candidatas.

This paper presents the basis for LoGlo PDT, a new treatment for glioblastoma. Glioblastoma is currently treated with maximal safe resection, temozolomide, and ionizing irradiation. Mortality in 2024 remains over 80% within several years from diagnosis. Oral 5-aminolevulinic acid (5-ALA) is an FDA/EMA approved drug that is selectively taken up by malignant cells, including by glioblastoma. In photodynamic treatment of glioblastoma, intense intraoperative light causes glioblastoma tissue that has taken up 5-ALA to generate cytotoxic reactive oxygen species. The requirement for intense light flux has restricted photodynamic treatment to a single one-hour intraoperative session. We analyze here published data showing that external light, illuminating the entire intact scalp, can attain low μW/cm2 flux several cm into intact brain that would be sufficient to mediate 5-ALA photodynamic treatment of glioblastoma if the light and 5-ALA are delivered continuously over 24 h. At the core of LoGlo PDT regimen is the dataset showing that, for a given fluence, as the duration of PDT light delivery goes down, light intensity (flux) delivered must go up to achieve the same glioblastoma cell cytotoxicity as would a weaker light (lower flux) delivered over a longer time. Thus, a repetitive, noninvasive PDT of glioblastoma using an external light source may be possible. We analyze 5-ALA cellular physiology to show that three non-oncology drugs, ciprofloxacin, deferiprone, and telmisartan, can be repurposed to increase light energy capture after 5-ALA, thereby increasing photodynamic treatment’s glioblastoma cell cytotoxicity. The LoGlo PDT approach uses both drug augmentation and prolonged ultra-low noninvasive transcranial light delivery for a repetitive, noninvasive 5-ALA photodynamic treatment of glioblastoma.

The multicultural landscape of Aotearoa New Zealand presents a rich tapestry of diversity and community needs, underscoring an imperative for inclusive participatory planning processes. This paper presents findings from an investigation of the challenges and opportunities inherent in community engagement initiatives, particularly within the context of New Zealand’s major ethnic groups, including New Zealand European, Māori, Chinese, and Pasifika. Drawing from the importance of community participation in reshaping public open spaces, this research addressed the gap in understanding which participatory planning processes are most effective across diverse cultural groups. To investigate the effectiveness of various approaches to community engagement, this research involved focus groups from the Wellington suburbs of Newtown and Porirua, utilising both on-site and online meetings. The findings identify the most effective participation processes for planning public open spaces in relation to each ethnicity. Correlations between participant preferences and their unique cultural backgrounds were assessed. In addition, the least effective participation methods along with several relatively effective participation methods are discussed. By highlighting engagement methods that can foster inclusivity, equity, and a sense of community, this research advances a collective goal of building a more cohesive and effective society for all its inhabitants.

Resumo Neste texto, percorrem-se os mapas desenhados por comunidades do povo Hupd’äh durante a elaboração do Plano de Gestão Territorial e Ambiental da Terra Indígena Alto Rio Negro (PGTA), entre 2015 e 2019. Recentemente, trabalhos de mapeamento tomaram relevo nas comunidades, seja como demanda para a incorporação em atividades escolares, seja como mediadores em discussões mais amplas. O exercício proposto é o de realizar uma descrição etnográfica da produção destes desenhos, buscando delinear possibilidades de leitura antropológica. O texto é divido em quatro tópicos. Inicialmente, são apresentadas informações contextuais e históricas sobre os Hupd’äh, passando a uma breve descrição das oficinas realizadas nos trabalhos do PGTA. O cerne do texto trata dos mapas propriamente ditos, trazendo o processo de desenhar, a territorialidade que indicam seus traços, lugares, toponímias e histórias que compõem essas iconografias de n¯ih s’ah (‘nossa terra’). O tópico final pontua algumas leituras possíveis dessas iconografias como experiências compartilhadas entre anciãos e jovens e como uma linguagem possível para a afirmação territorial.

Energy consumption in the world is based on two types of sources: fossil fuels and renewable energy. In this case, bioethanol presents itself as an alternative resource to fossil fuels, whose production can occur through specific processes called alcoholic fermentation. In parallel, the growing demand for energy has motivated scientists to develop even more efficient systems and technologies. In this work, mathematical modeling and simulation was performed to represent the kinetics of alcoholic fermentation in a fed-batch bioreactor. The modeling was developed taking into account the microbial inhibition caused by the presence of excess substrate and product through the Tosetto and Hoppe-Hansford models. In the simulation, Bayesian statistics was used as a tool to estimate the kinetic parameters and the state variables of the bioprocess. The estimates were obtained through the use of a particle filter proposed by Liu and West, with 500 particles and experimental measurements from the literature, whose approach presented 99% accuracy and proved to be effective for describing alcoholic fermentation.

The treatment of industrial effluents has great environmental and human health importance. The purification of water from polluting components, such as metals and organic compounds, can be considered one of the main applications in this field, with adsorption being one of the main treatment methods. Therefore, with the objective of describing the dynamics of the process in an adsorption column and estimating the parameters involved, in this work, an algorithm for the Method of Lines (MOL) was used in order to numerically solve the model formed by the mass balance in liquid phase, the linear driving force equation (LDF), and the Langmuir isotherm for equilibrium. In addition, a sensitivity analysis of the phenomenon was carried out in relation to the parameters and a subsequent estimation of these was made through the Monte Carlo technique via the Markov chain (MCMC). The validation algorithm was created using data from actual breakthrough curves found in the literature. The experimental data were obtained from the literature for the adsorption of Cadmium (Cd), Copper (Cu), Nickel (Ni), Zinc (Zn), and Chrome (Cr) ions. Among all the estimates, the one that had the lowest adjustment to the data was that related to zinc metal, which had an R2 equal to 0.8984. For the other metals, the correlation coefficient had a value closer to unity. This demonstrates that, in general, the estimates were good enough to represent the dynamics of adsorption.

Diante da compreensão de que compartilhamos um passado histórico e sociocultural recente e similar (semiperiférico, ditatorial, colonial, cristão, monoteísta patriarcal), o que as artes ibero-americanas teriam a dizer sobre as ficções dominantes e com que ferramentas estéticas e dissensuais fariam frente a um consenso policialesco de gênero, sexualidade, raça e classe social? Que cenas, gestos e rostos, mesmo que transitórios, ambíguos e relacionais, poderiam perturbar determinados regimes policialescos não apenas de raça, gênero e classe, mas também perturbar as próprias ficções dominantes no campo das artes? Com este número, pretendemos analisar então as operações discursivas e estéticas que ocorrem quando são as subjetividades subalternas que representam a si mesmas, em vez de serem retratadas a partir do olhar de um Outro hegemônico que frequentemente procura coisificá-las, dominá-las e observá-las de uma distância que não contamine sua subjetividade.

ABSTRACTRenewed focus on mental health has put the spotlight on the ‘black box’ that is the acute mental health facility. Drawing on a larger programme of research, key issues relevant to the planning and design of mental health units were identified from in-depth interviews with those using the facilities. Contemporary issues included visibility from the outside and wayfinding, the need to accommodate cultural needs extending to the family and community, safety and violence, the need for access to nature and fresh air, and facilitating meaningful activities. Stigma and its spatial expression were a crosscutting theme throughout.Trial registration: Australian New Zealand Clinical Trials Registry; identifier: ACTRN12617001469303.

In this article, we contend that understanding Brazil’s current communicative landscape requires a closer examination of the relevance of legacy media outlets, challenging the widely accepted “traditional media bypass” thesis, which posits that social media platforms have overtaken traditional media as the primary influencers of political discourse, an argument often used to explain the rise of extreme-right ideologies across different national contexts. In order to test the association between voting preferences and the use of different types of media, we employ logistic regression analysis using data from a recent survey that includes numerous questions about the information and media consumption habits of Brazilian voters. Our findings highlight that legacy media, particularly broadcast TV channels like Globo, Record, and SBT, remain dominant in Brazil as sources of political information. Contrary to the bypass thesis, Bolsonaro’s supporters, while favoring social media, also consume significant amounts of legacy media. Analysis reveals stark differences in media preferences between the supporters of different political candidates, challenging the notion of an exclusive reliance on social media by right-wing supporters. The data also indicate nuanced media consumption habits, such as a preference for certain TV channels and fact-checking behaviors, underscoring the complex interplay between legacy and social media.

Abstract We draw current efforts towards proposing a wing-type micro UAV with characteristics of being a basic operation risk self handled (Micro-Brosh) platform. Its micro-sized wingspan and weight, which are less than 0.30 m and 0.150 kg, respectively, guarantee the low risk to the operator and installations in case of crashing. It can be launched manually without using an appropriate runway, besides using a soft grass field for landing is recommended. Its associated costs for construction and maintenance are very low (below US$ 500) if compared to traditional aircraft. The main contribution here is the architectural design, besides we provide detailed documentation including techniques for determining lift, thrust, drag, minimum flight velocity, maximum time of flight and distance (autonomy), and other issues that we have solved related to the aircraft development. We validate our prototype with experiments including several tests done with the UAV with results that have proven its flight ability. To the end, we understand that this work provides a nice starting document to researchers that intend to develop a UAV or enter this field.

This research is focused on investigating the utilization of Bayesian methodologies, specifically the Markov Chain Monte Carlo method, as well as filter sampling by importance and sequential resampling. The objective is to estimate kinetic parameters and state variables associated with the uranium bioleaching process by Acidithiobacillus ferrooxidans. Experimental data of cell concentration, uranium concentration, and concentrations of ferrous and ferric ions, obtained from literature, were employed. These measurements were evaluated using a mathematical model expressed by a system of ordinary differential equations. Three different mathematical models were evaluated, considering different uncertainties in experimental measurements and mathematical models (1% and 5%). The estimation results presented a good fit to the experimental data, with coefficients of determination in the range of 0.95 to 0.99. The validation of the mathematical models was obtained by reproducing the experimental measurements and the Bayesian techniques proved to be suitable for application in the bioleaching process.

We propose a new double-hybrid concept and architectural design of a tailsitter unmanned aerial vehicle with vertical takeoff and landing capability. Basically, it consists of a modified flying wing with a single combustion powertrain set and a multirotor with 2 powertrain sets with electric motors. With the electric propellers fixed at the leading wing edge, the tailsitter has two standard surfaces for elevation control and two vertical stabilizers that are used to give the necessary direction on vertical takeoff and landing. We have designed, built, and tested a prototype based on this new double-hybrid concept, which spends less energy on vertical taking off and landing and also on horizontal flight, thus maximizing flight endurance and travelled distance. We performed several experimental tests starting with the aircraft on the ground in vertical positioning. These tests include executing vertical takeoffs and landing, transitions from vertical to horizontal flight modes and transitions back (from horizontal to vertical), and hovering, which were carried out successfully. Transitions fourth and back from combustion to multirotor are inherent to some of those flight mode transitions, which have also been performed smoothly. We also performed tests (in bench) to estimate the maximum flight duration, which has demonstrated about 32 minutes of endurance. To this end, the proposed and currently built double-hybrid prototype has proven to be functional as an effective hybrid UAV system.

Resumo A partir da experiência do projeto Respostas Indígenas à COVID-19 no Brasil: arranjos sociais e saúde global (PARI-c), na região do Alto Rio Negro (AM), buscamos refletir neste artigo sobre as possibilidades e implicações da produção colaborativa de conhecimento com pesquisadoras indígenas, levando em consideração a emergência sanitária, as imobilidades territoriais, as desigualdades sociais e as diferenças epistemológicas e de políticas ontológicas. A partir da ideia de Cestos de conhecimento, pensamos as formas e possibilidades dessa colaboração, à luz de discussões contemporâneas sobre processos de “descolonização” da saúde pública (global, planetária) e do conhecimento em saúde. A base empírica para este artigo é uma descrição da experiência metodológica, de produção de conhecimento, focada em duas faces: o campo e a escrita. Esse material nos permite tecer algumas considerações em torno da relevância e do sentido de formas de geração de “saberes híbridos”, para lidar com contextos de crises globais ou sindemias. Estas formas, como veremos, atravessam o realinhamento das alianças e têm na escrita de mulheres um lugar especial de atenção.

This article analyzes the judiciary system’s tendency to unify multiple jurisprudences and eventual conflicts with cultural diversity. The judiciary system’s interpretation of laws is interpreted with skepticism, as they might result in derogation of the legislative prerogatives. Critics have gained strength from the actual procedure code's disposals that made compulsory judiciaries pronounce in state and national levels. The present study investigates how judicial understandings of laws could provide voices to the diversity of cases that might eventually be submitted to the Courts' analyses. The broad participation of the amicus curiae in each biding case along with the full applicability of atypical procedural agreements should be conceived as an indispensable condition to give plain social validity and maximum effectiveness to the judiciary pronunciation, especially whenever regarding the most fundamentals concepts of the democratic archetypes resembling the main ideas forecasted by the second generation of the Frankfurt Philosophical School, among whom Jürgen Habermas is considered as the field’s most influential author. The present study uses a dialect-inductive methodology to confirm the hypothesis that both state and superior Courts must analyze various juridical divergent theses so that the bindings might not lack social effectiveness, especially by using the amicus curiae's opinion thoroughly.

O artigo centra-se nos efeitos que a ocorrência de desastres socioambientais exerce sobre a ação política dos parlamentares. Nosso objetivo é analisar o comportamento parlamentar em um momento crítico, qual seja, o desastre da barragem de Fundão, operada pela Samarco/Vale/BHP. Busca-se, especificamente, responder a duas questões: o que os deputados federais propuseram acerca do desastre, e se tais iniciativas se relacionam às doações de campanha. Para tanto, analisamos as propostas legislativas apresentadas pelos deputados federais, entre 05 novembro de 2015, data de ocorrência do desastre, e 31 de dezembro de 2018. Constatamos que a maioria dos deputados com alto nível de financiamento da Samarco se abstiveram de apresentar proposições acerca do desastre. Os parlamentares com atuação contrária à empresa são oriundos principalmente dos estados atingidos pelo desastre (Minas Gerais e Espírito Santo), o que sinaliza para atuação no sentido de prestação de contas a seus eleitores.

Resumo Desde a declaração do estado pandêmico global em decorrência do novo coronavírus (Sars-CoV-2) pela Organização Mundial de Saúde (OMS), em 11 de março de 2020, diversas têm sido as medidas tomadas por governos ao redor do mundo em relação ao distanciamento social. No caso brasileiro, os governos estaduais anteciparam-se com a decretação de medidas de fechamento de escolas, suspensão de eventos públicos e restrição do comércio. O objetivo deste paper é analisar as diferenças entre os governos estaduais do Brasil relativamente à implementação de intervenções não farmacêuticas (NPIs) para o enfrentamento ao coronavírus, com base no cálculo de um índice de ação governamental. Tendo em vista a consecução deste objetivo geral, foram analisados 367 decretos de 25 executivos estaduais brasileiros nos dois primeiros meses da pandemia no país (final de fevereiro e final de abril). Os resultados preliminares desta análise sugerem diferentes níveis de rigor das medidas para o enfrentamento à COVID-19 por parte dos governos estaduais brasileiros, destacando-se a adoção proativa de políticas mais rigorosas de distanciamento social por alguns estados, antes mesmo da confirmação do primeiro caso da doença em seus domínios.

Abstract Objectives To evaluate the first‐attempt success rates and complications of endotracheal intubation of coronavirus disease 2019 (COVID‐19) patients by emergency physicians. Methods This prospective observational study was conducted from March 24, 2020 through May 28, 2020 at the emergency department (ED) of an urban, academic trauma center. We enrolled patients consecutively admitted to the ED with suspected or confirmed COVID‐19 submitted to endotracheal intubation. No patients were excluded. The primary outcome was first‐attempt intubation success, defined as successful endotracheal tube placement with the first device passed (endotracheal tube) during the first laryngoscope insertion confirmed with capnography. Secondary outcomes included the following complications: hypotension, hypoxemia, aspiration, and esophageal intubation. Results A total of 112 patients with confirmed or suspected COVID‐19 were enrolled. Median age was 61 years and 61 patients (54%) were men. The primary outcome, first‐attempt intubation success, was achieved in 82% of patients. Among the 20 patients who were not intubated on the first attempt, 75% were intubated on the second attempt and 20% on the third attempt; cricothyrotomy was performed in 1 patient. Forty‐eight (42%) patients were hypotensive and required norepinephrine immediately post‐intubation. Fifty‐eight (52%) experienced peri‐intubation hypoxemia, and 2 patients (2%) had cardiac arrest. There were no cases of failed intubation resulting in death up to 24 hours after the procedure. Conclusion Emergency physicians achieve high success rates when intubating COVID19 patients, although complications are frequent. However, these findings should be considered provisional until their generalizability is assessed in their institutions and setting.

Centrando-se na exposição que João Pedro Vale e Nuno Alexandre Ferreira apresentaram em 2018 na Galeria Cristina Guerra (Lisboa), o presente artigo aborda as estratégias discursivas de repressão à identidade homossexual durante o período do Estado Novo. Analisando as obras exibidas e sua recepção crítica, recorremos à conceptualização foucaultiana em torno do panóptico e da estratégia arqueológica enquanto arquivo marginal (queer). À supressão oficial do termo “homossexual”, Vale e Alexandre respondem com a palavra inglesa “cruising”, a fim de podermos classificar um conjunto de práticas interditas que, em Portugal, ainda recentemente não podiam ser nomeadas.

Qual a diferença entre as imagens que passam diante dos nossos olhos e aquelas que o imaginário produz? Quais as mais poderosas e “subversivas”? O que justifica, nesse caso, a censura? As imagens em si, os seus propósitos ou os seus usos? São as imagens que são censuradas ou o que pensamos e fazemos depois com elas? A tensão entre visibilidade e invisibilidade, entre imagem vista e imagem imaginada, endereça-nos para as complexas relações entre literatura e artes visuais. A tentativa de controlar o discurso público legitimando certas vozes e relegando outras ao silêncio constitui um dos principais objetivos da censura. Esta está intimamente ligada ao exercício da coerção estatal com o fim de se impor uma ideologia a pretexto da proteção dos valores de uma sociedade.

Abstract The aim of this study was to determine the occurrence of tick-borne pathogens (Ehrlichia canis, Babesia vogeli, Hepatozoon spp. and Rickettsia spp.) in dogs in Vila de Jericoacoara, coastal region of Ceará, Brazil. Blood samples were collected from 153 animals and analyzed using molecular and serological methods. Sixty animals were found to be infected or exposed to at least one of the pathogens studied. Babesia vogeli was the most prevalent pathogen (15%), followed by E. canis (13.7%) and Hepatozoon spp. (11.8%), which was identified as Hepatozoon canis through sequencing. Twenty dogs (13%) were seroreactive to Rickettsia spp. Rhipicephalus sanguineus sensu lato was observed on 11.8% of the animals. There were associations between age (< 3 years old) and positivity for B. vogeli, and between habitation (stray dogs) and positivity for H. canis. There were also associations between anemia and infection with H. canis, and between leukopenia and exposure to Rickettsia spp. No association was detected between clinical alterations and infection with or exposure to the pathogens studied. The results confirmed that pathogens of veterinary importance are circulating in northeastern Brazil and showed that dogs are exposed to Rickettsia species with zoonotic potential, thus indicating a need for vector control measures.

Objective: To evaluate genotoxicity of zinc oxide, P. A. calcium hydroxide, mineral trioxide aggregate and an iodoform paste using comet assay on human lymphocytes. Material and Methods: Two positive controls were used: methyl-methanesulfonate for the P.A. calcium hydroxide and mineral trioxide aggregate; and doxorubicin for the iodoform paste and zinc oxide. There were also two negative controls: distilled water for the P.A. calcium hydroxide and mineral trioxide aggregate; and DMSO for the iodoform paste and zinc oxide. Comets were identified using fluorescence microscopy and 100 of them were counted on each of the three slides analyzed per drug test. A damage index was established, taking into consideration the score pattern that had previously been determined from the size and intensity of the comet tail. Analysis of variance, followed by Tukey’s test, was used to compare the means of the DNA damage indices. Results: The DNA damage index observed for mineral trioxide aggregate (7.08 to 8.58) and P.A. calcium hydroxide (6.50 to 8.33), which were similar to negative control index. On the other hand, damage index for zinc oxide (104.7 to 218.50) and iodoform paste (115.7 to 210.7) were similar to positive control index. Conclusion: Iodoform paste and zinc oxide showed genotoxicity at all concentrations used.

Aim: The aim of the study was to evaluate the cleaning of mandibular incisors with WaveOne Gold® (WO) under different preparation techniques. Methods: A total of 210 human mandibular incisors were selected and divided into seven groups (n = 30), prepared by WO single-files (Small 20/.07 – WOS; Primary 25/.07 – WOP; Medium 35/.06 – WOM; or Large 45/.05 - WOL) and sequential-file techniques (WOS to WOP; WOS to WOM; and WOS to WOL). Further subdivision was made according to irrigation protocol: control group (manual irrigation - CON), E1 Irrisonic® - EIR, and EDDY® - EDD. Debris removal and the smear layer were evaluated by scanning electron microscopy. Data were analyzed by using Spearman’s correlation test. The significance level was set at 5%. Results: For debris and smear layer removal, WOS and WOP, EIR differed from CON and EDD (p

This article analyses an audiovisual essay created around the exhibition Julião Sarmento. Film Works, that took place in Universidade Católica Portuguesa in Porto in 2019. This exhibition reunited 10 works in film and video produced by the Portuguese artist in different moments of his career. Following the audiovisual essay’s structure, I will approach three thematic obsessions transversal to Julião Sarmento’s work, as a reflexive proposal about a gaze phenomenology (or a vision’s perversity), regarding dispositives that involve the moving image. Particularly, in what concerns the problematic of desire. These are: (1) The constant work of language (the real, the symbolic and the imaginary); (2) The fragmented body (the conscience/disassembling of voyeurism); (3) The rhythm (exposing the matter of time in favor of a deceptive aesthetics).

Background: The common bean (Phaseolus vulgaris L.), is one of the most relevant legumes worldwide, as a source of protein, fiber, carbohydrates, and biologically important minerals. In recent decades, bean production increased significantly, especially in developing countries, where the availability of animal protein is often in short supply. However, a large portion of this agricultural production has been achieved in an unsustainable manner, through the intensive use of non-renewable agrochemicals, which in both the short and long term negatively affect soil fertility. To address this problem, the use of sustainable and renewable bio-inputs derived from macroalgae, and microorganisms may be amongst solutions required. Extracts of seaweeds have been shown to be biodegradable and non-toxic both for treated plants and consumers. This study aimed to evaluate the influence of the application of three bio-inputs made from different organisms on a common bean variety (BRSMG Realce) by analysing plant physiology and productivity, pod morphology, nutritional and mineral characterization of the bean. The study also aimed to evaluate the length of BRSMG Realce crop life cycle and compare its nutritional value with other commonly consumed varieties. Methods: Six treatments were performed: T0 — Control; T1 — Calmar® (soil — 100 kg/ha); T2 — Profertil® (foliar — 0.5%(v/v)); T3 — Albit® (leaf — 0.02%(v/v)); T4 — Calmar® ((100 kg/ha) + Profertil® (0.5%(v/v)); T5 — Calmar® ((100 kg/ha) + Albit® (0.02% (v/v)). Results: The leaf chlorophyll index revealed significant increases for T2, T4 and T5, compared to control. In general, the treatments related to the pods morphology showed significant increases in the length/width ratio. In terms of productivity, significant increases were found with T1, T4 and T5. In the analysis of the nutritional value of dried beans there were significant increases in the contents of fiber in T1, protein in T4 and T5 and carbohydrates for T1, T2 and T3. For mineral composition, there were increases in the phosphorus content of T2, T4 and T5 beans. When the cooked beans were analysed, T4 and T1 produced a greater amount of ash and proteins, as compared to control. Conclusions: The applications of bio-inputs in the bean crop (Phaseolus vulgaris L.) exerted several positive and significant effects, mainly on the CCI, productivity, pod morphology as well as cooked bean nutritional values. It was verified that BRSMG Reakce has the potential to be included in the Portuguese diet.

BackgroundPeople who smoke with serious mental illness carry disproportionate costs from smoking, including poor health and premature death from tobacco-related illnesses. Hospitals in New Zealand are ostensibly smoke-free; however, some mental health wards have resisted implementing this policy.AimThis study explored smoking in acute metal health wards using data emerging from a large sociological study on modern acute psychiatric units.MethodsEighty-five in-depth, semi-structured interviews were conducted with staff and service users from four units. Data were analysed using a social constructionist problem representation approach.ResultsAlthough high-level smoke-free policies were mandatory, most participants disregarded these policies and smoking occurred in internal courtyards. Staff reasoned that acute admissions were not the time to quit smoking, citing the sceptres of distress and possibly violence; further, they found smoking challenging to combat. Inconsistent enforcement of smoke-free policies was common and problematic. Many service users also rejected smoke-free policies; they considered smoking facilitated social connections, alleviated boredom, and helped them feel calm in a distressing environment - some started or increased smoking following admission. A minority viewed smoking as a problem; a fire hazard, or pollutant. No one mentioned its health risks.ConclusionPsychiatric wards remain overlooked corners where hospital smoke-free policies are inconsistently applied or ignored. Well-meaning staff hold strong but anachronistic views about smoking. To neglect smoking cessation support for people with serious mental illness is discriminatory and perpetuates health and socioeconomic inequities. However, blanket applications of generic policy are unlikely to succeed. Solutions may include myth-busting education for service users and staff, local champions, and strong managerial support and leadership, with additional resourcing during transition phases. Smoke-free policies need consistent application with non-judgemental NRT and, potentially, other treatments. Smoking cessation would be supported by better designed facilities with more options for alleviating boredom, expressing autonomy, facilitating social connections, and reducing distress.

Nesse texto analisamos a distribuição de recursos financeiros via organizações partidárias para os candidatos ao cargo de deputado federal, no Rio Grande do Sul, em 2014, nos principais partidos políticos da competição estadual: PP, PMDB, PSDB, PDT e PT. Por meio dos dados do Tribunal Superior Eleitoral (TSE)sobre os recursos financeiros que são destinados pelos partidos políticos aos candidatos, tínhamos como hipótese que: os partidos políticos não distribuem esses recursos de forma equitativa. Na prática, isso significa a preferência, e a criação de uma “lista informal” dos candidatos “selecionados” pelos partidos. Os resultados indicam que todos os partidos políticos investiram mais nos incumbentes do que nos candidatos novatos, sendo o PSDB uma das agremiações que depositou mais da metade do fundo em apenas um dos seus dezoito candidatos. Esses dados sugerem, que os partidos políticos possuem algum tipo de controle sobre a condução do pleito eleitoral. Nesse quesito, não podem ser entendidos como organizações “frouxas”, pois a elite partidária detém a capacidade de influenciar aqueles que serão os representantes da agremiação na Câmara Federal.

Que espaço ocupa o retrato num panorama que dá tanta ênfase ao corpo? É caso para dizer que o corpo, a partir das últimas décadas do século XX, se tornou num significante despótico que subordina qualquer expressão artística chegando mesmo ao ponto de afectar a prática do retrato ousando eclipsar daquilo que com ele estava mais conotado: a imagem de um rosto. Partindo do conceito de visagéité de Gilles Deleuze e Félix Guattari e das noções “paisagens-corpos”, “paisagens-rostos” e “devir-rosto” desenvolvidas por José Gil, predentemos com este ensaio reflectir sobre um processo que aqui designamos de “transferência de funcionalidade”, através da qual o corpo se torna “rosto”.

Objectives The objectives of this study were to confirm the prevalence of feline immunodeficiency virus (FIV) infection in domestic cats in the region north of Ceará, Brazil, and to determine the factors associated with infection and the major circulating subtypes of the virus in this area. Methods Samples from 148 cats were collected and tested using anti-FIV antibody screening, with confirmation of positive results by PCR. Univariate analysis was performed considering the epidemiological characteristics and FIV status. Sequencing and phylogenetic analysis of the gag and pol genes were performed to confirm the FIV subtype. Results Nine cats (6.1%) tested positive for FIV – one female (0.7%) and eight males (5.4%). Male cats were significantly more likely to be infected ( P

Degradation of ecosystem services, scarcity of resources and the erosion of the planet’s capability to absorb waste is of immediate concern. This situation is novel in its speed, its global and local scale and its threat to the planet and its people. Inspired by the recent discourse of the Anthropocene, this paper explores the convergence of human and nature as they confront generative and destructive forces in two distinctly different settings. Using a case-study approach, this paper adopts the cyborg landscape as a conceptual framework to address the interconnectedness of systems, and scale and poetic brief to accommodate the environment while supporting the needs of our contemporary society. By using nature’s generative capacities as well as its destructive tendencies and by blurring the disciplinary boundaries between interior architecture and landscape architecture, this paper considers two different locations in New Zealand: a post-industrial site on Auckland’s urban waterfront and a remote active volcanic site located on White Island. It finds opportunity to examine intensified inhabitation through acts of immersion and extraction in the “new normal” where nature’s interrelated systems and the artifice of the Anthropocene create innovative and dynamic possibilities. It concludes that the creation of a link between natural processes and responsive technologies can provide solutions to address the complexity of climate change.

The connection the Māori, the Indigenous people of Aotearoa-New Zealand, have to the land is threatened by the effects of colonisation, urbanisation and other factors. In particular, many Māori suffer significant health and wellbeing inequalities compared to the non-Māori population. In an effort to reduce such inequalities, there is a growing consciousness of the need to better understand the cultural and place-specific determinants that affect the health and wellbeing of population groups in different environments. This article explores how environmental and cultural connections to land enable the development of place-specific and culturally-driven principles that promote the health and wellbeing of Māori populations. It argues that concepts of place, belonging, landscape and wellbeing play an important role in linking environment and culture as well as in contributing to creating therapeutic spatial environments that promote both human health and ecosystems. A set of principles is developed that allows for the landscape design of such therapeutic environments while accommodating the socio-cultural and environmental values that promote health and wellbeing of both Māori and non-Māori people.

The use of technology for social connectivity and achieving engagement goals is increasingly essential to the overall well-being of our rapidly ageing population. While much of the extant literature has focused on home automation and indoor remote health monitoring; there is a growing literature that finds personal health and overall well-being improves when physical activities are conducted outdoors. This study presents a review of possible innovative and assistive eHealth technologies suitable for smart therapeutic and rehabilitation outdoor spaces for older persons. The article also presents key performance metrics required of eHealth technologies to ensure robust, timely and reliable biometric data transfer between patients in a therapeutic landscape environment and respective medical centres. A literature review of relevant publications with a primary focus of integrating sensors and eHealth technologies in outdoor spaces to collect and transfer data from the elderly demographic who engage such built landscapes to appropriate stakeholders was conducted. A content analysis was carried out to synthesize outcomes of the literature review. The study finds that research in assistive eHealth technologies and interfaces for outdoor therapeutic spaces is in its nascent stages and has limited generalisability. The level of technology uptake and readiness for smart outdoor spaces is still developing and is currently being outpaced by the growth of elderly fitness zones in public spaces. Further research is needed to explore those eHealth technologies with interactive feedback mechanisms that are suitable for outdoor therapeutic environments.

O objetivo do estudo foi identificar os modelos que melhor explicam as relações entre as variáveis do scout dos jogos da Copa do Mundo de futebol de 2014. Foram analisados os 32 jogos da competição. Os dados foram retirados do site oficial da Federação Internacional de Futebol (FIFA). Os resultados indicaram que os modelos para as variáveis passes certos (r²=0,710), posse de bola (r²=0,679), cruzamentos (r²=0,639) e gols feitos (r²=0,608) foram significativos (p

This study aimed to verify the viability of propagation material from coffee plants descended from germplasm susceptible to blister spot disease as well as its susceptibility to Colletotrichum sp. relative to commercial coffee cultivars. In the first experiment, fruits were harvested from plants with and without symptoms of blister spot and sowed in trays containing a commercial sterilized substrate. The percentages of germinated seeds, viable plantlets and seedlings were evaluated. In diseased tissues, pathogens were isolated and identified though a pathogenicity test. In the second experiment, ten commercial cultivars and one cultivar originating from plants with blister spot were inoculated with the pathogens to assess the severity of anthracnose. Significant differences were not observed with respect to seed germination. However, the viability of plantlets and seedlings was reduced in the cultivar originating from plants with blister spot (Genotype Originated from Diseased Plants-GODP). These plants showed characteristic symptoms of blister spot, including necrosis in the leaves and hypocotyls, wilting and death. In the necrotic lesions, we observed characteristic sporulation of Colletotrichum sp. The cultivar most susceptible to anthracnose in cotyledonary leaves was Catuaí Vermelho (GODP), which presented the highest area under the disease progress curve (AUDPC). In conclusion, the viability of propagation material from coffee plants that had descended from plants with symptoms of blister spot (GODP) was reduced compared with plants from other genotypes, although seed germination was not affected. Moreover, GODP species are more susceptible to Anthracnose on the cotyledonary leaves relative to the other analyzed commercial cultivars. This work is the first to report on different symptoms exhibited by seedlings originating from the seeds of plants with symptoms of blister spot..

Compounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to identify the molecular characteristics which contribute to their cytotoxicity, which was tested against OVCAR-8, HCT-116, and SF-295 human tumor cell lines, using the MTT assay. The results of this study showed that (−)-perillaldehyde 8,9-epoxide exhibited the highest percentage inhibition of cell proliferation (GI = 96.32%–99.89%). Perillyl alcohol exhibited high cytotoxic activity (90.92%–95.82%), while (+)-limonene 1,2-epoxide (GI = 58.48%–93.10%), (−)-perillaldehyde (GI = 59.28%–83.03%), and (−)-8-hydroxycarvotanacetone (GI = 61.59%–94.01%) showed intermediate activity. All of the compounds tested were less cytotoxic than perillyl alcohol, except (−)-perillaldehyde 8,9-epoxide (IC50 = 1.75–1.03 µL/mg). In general, replacement of C-C double bonds by epoxide groups in addition to the aldehyde group increases cytotoxicity. Furthermore, stereochemistry seems to play an important role in cytotoxicity. We have demonstrated the cytotoxic influence of chemical substituents on the p-menthane structure, and analogues of perillyl alcohol.

Beyond the difficulties in circumscribing expanded cinema theoretical and epistemological field – due to the plurality and multiple developments that it comprises, - one of the most pressing aspects concerning expanded cinema refers its relation with problems of narrativity. Although less obvious, the mention to Julião Sarmento’s work in this field seems to us particularly useful; to begin with, for the way his work is animated by a counter-narrative compulsion which, building up in the interior of a specific dialectic between cinema and photography, efficiently undermines structural centeredness and the linearity of sequential images. Following a thread encompassing the experimental films from the mid-70s to the installations of 2000s, we seek to argue that the importance of structuralism, as well the genealogical approach to the history and memory of cinema, constitute, within Sarmento’s oeuvre, increasingly important aspects to assess the new forms of perceptive, cognitive and topological arrangements that go along the emergence of the so called expanded cinema. Ultimately, the originality and the critical stance maintained by the artist leads us towards the consideration of an anti-expanded-cinema: more than a thematic traced within the limits of technological development and multi-disciplinary spreading, in Sarmento’s case, the expansion of cinema concerns, mostly, the expansion of the criteria related with the circulation of thought and desire throughout a topology of infra-signification that emerges from the new possibilities of narration, of making and exhibiting cinema. Accordingly, what is at issue is an overall distinct possibility of identify, designate and problematize the category of expanded cinema, beyond its orthodox definition.

Atualmente verifica-se uma evolução do sistema educativo português, no sentido de tornar as escolas públicas verdadeiras comunidades educativas de inclusão, onde todos os alunos têm iguais oportunidades de aprendizagem. . A presente comunicação resulta de um estudo conduzido com o intuito de conhecer as percepções/atitudes dos pais com filhos com necessidades educativas especiais face a uma educação inclusiva.

Abstract: The aim of this study was to compare two irrigation techniques and four devices for endodontic sealer placement into the dentinal tubules. Ninety-nine single-rooted human teeth were instrumented and allocated to either the control (CO) (n=11) or experimental groups according to the irrigation method: syringe and NaveTip needle (NT) (n=44), and EndoActivator (EA) (n=44). These groups were subdivided according to sealer placement into K-File (KF), lentulo spiral (LS), Easy Clean (EC), and EndoActivator (EA) subgroups. Moreover, the distances of 5 mm and 2 mm from the apex were analyzed. The teeth were obturated with AH Plus and GuttaCore X3. Analyses were performed by scanning electron microscopy associated to cathodoluminescence. The percentage and maximum depth of sealer penetration were measured. Data were evaluated by three-way analysis of variance (ANOVA) and Games-Howell test (p

Nesse texto analisamos a distribuição de recursos financeiros via organizações partidárias para os candidatos ao cargo de deputado federal, no Rio Grande do Sul, em 2014, nos principais partidos políticos da competição estadual: PP, PMDB, PSDB, PDT e PT. Por meio dos dados do Tribunal Superior Eleitoral (TSE) sobre os recursos financeiros que são destinados pelos partidos políticos aos candidatos, tínhamos como hipótese que: os partidos políticos não distribuem esses recursos de forma equitativa. Na prática, isso significa a preferência, e a criação de uma “lista informal” dos candidatos “selecionados” pelos partidos. Os resultados indicam que todos os partidos políticos investiram mais nos incumbentes do que nos candidatos novatos, sendo o PSDB uma das agremiações que depositou mais da metade do fundo em apenas um dos seus dezoito candidatos. Esses dados sugerem, que os partidos políticos possuem algum tipo de controle sobre a condução do pleito eleitoral. Nesse quesito, não podem ser entendidos como organizações “frouxas”, pois a elite partidária detém a capacidade de influenciar aqueles que serão os representantes da agremiação na Câmara Federal.

Dentro de una zona tan competitiva como la del Caribe, el impresionante progreso del turismo de crucero otorga a Dominica un aspecto simbólico de éxito para el desarrollo de dicha actividad. Este artículo adopta un enfoque sistémico y demuestra que tres protagonistas concentran más de 70% de los beneficios financieros de la actividad crucerista : las agencias de viajes, el comercio del recuerdo y las compañías cruceristas. La escasa dispersión del número de beneficiarios es concomitante con la concentracion espacial de la actividad, como con la falta de beneficiarios macro económicos del sector crucerista en Dominica. Este análisis consagrado a Dominica sugiere un modelo del sector crucerista fuertemente concentrado que se apoya en cuatro pilares : los tours organizados como principal recurso para descubrir la isla, la fuente de recetas para las compañias cruceristas, cuyos contratantes (las agencias locales) son los primeros canales del impacto económico de esta actividad concentrada tanto a nivel geografico como financiero, generando un escaso impacto macroeconómico.

Desde hace años el turismo internacional se ha convertido en una especialización de la región del Caribe. La pregunta sobre si la contribución de las ganancias del turismo internacional ha repercutido en las rentas de la población del Caribe, ha generado un ámbito de estudio tanto teórico como práctico. Estructurando el concepto de contribución alrededor de las nociones de causalidad y elasticidad, este artículo presenta varios datos resumidos y aplicables a todo el conjunto del Caribe, por lo que mira más allá de la diversidad que caracteriza la región. La econometría del panel de datos proporciona el marco para las observaciones siguientes y las regresiones que de ellas pueden ser estimadas nos proporcionan información sobre la contribución dinámica del turismo internacional a los ingresos de la región.

O artigo pretende abordar as reformas implementadas na Polícia Militar do Estado do Rio de Janeiro (PMERJ) nos governos de Leonel Brizola (1983-95), a partir da tentativa de implementação do programa de policiamento comunitário. Atentos às novas estratégias internacionais de policiamento ostensivo, os novos gestores da PMERJ redefiniram o papel da corporação a partir de conceitos como prevenção, integração e legalidade, encarando o crime como um “problema público”. A Secretaria da PMERJ tentou construir um novo marco regulatório na administração da segurança pública no Rio de Janeiro. O novo comando policial-militar, ao buscar a adequação entre o trabalho policial e os objetivos das comunidades, combateu as tradicionais políticas de controle social, pondo em questão a exclusão dos populares nos processos de decisão em termos de política de segurança. Assim, esses oficiais reformistas ofereceram contornos institucionais concretos ao discurso brizolista dos direitos humanos.