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Your search keyword '"Bu, Meng-Meng"' showing total 12 results
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12 results on '"Bu, Meng-Meng"'

4. Biotransformation of antioxidant eriocitrin into characteristic metabolites by the gut microbiota.

Author

Zhang, Hao-jian, Yu, Hang, Fu, Jie, Keranmu, Adili, Zhang, Zheng-Wei, Xu, Hui, Hu, Jia-Chun, Lu, Jin-Yue, Yang, Xin-Yu, Bu, Meng-Meng, Zhai, Zhao, Wang, Jing-yue, Jiang, Jian-Dong, and Wang, Yan

Subjects
T-test (Statistics), GUT microbiome, FLAVONOIDS, ANTINEOPLASTIC agents, QUANTITATIVE research, DESCRIPTIVE statistics, BIOTRANSFORMATION (Metabolism), PLANT extracts, METABOLITES, ANTIOXIDANTS, ANIMAL experimentation, GLYCOSIDES, MASS spectrometry, MOLECULAR structure, ANALYSIS of variance
Abstract

Eriocitrin is a flavonoid glycoside with strong antioxidant capacity that has a variety of pharmacological activities, such as hypolipidemic, anticancer and anti-inflammatory effects. We found that the gut microbiota could rapidly metabolize eriocitrin. By using LC/MSn-IT-TOF, we identified three metabolites of eriocitrin metabolized in the intestinal microbiota: eriodictyol-7-O-glucoside, eriodictyol, and dihydrocaffeic acid. By comparing these two metabolic pathways of eriocitrin (the gut microbiota and liver microsomes), the intestinal microbiota may be the primary metabolic site of eriocitrin metabolism. These findings provide a theoretical foundation for the study of pharmacologically active substances. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Biotransformation of antioxidant eriocitrin into characteristic metabolites by the gut microbiota

Author

Zhang, Hao-jian, primary, Yu, Hang, additional, Fu, Jie, additional, Keranmu, Adili, additional, Zhang, Zheng-Wei, additional, Xu, Hui, additional, Hu, Jia-Chun, additional, Lu, Jin-Yue, additional, Yang, Xin-Yu, additional, Bu, Meng-Meng, additional, Zhai, Zhao, additional, Wang, Jing-yue, additional, Jiang, Jian-Dong, additional, and Wang, Yan, additional

Published
2023
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6. Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain

Author

Zhang, Zheng-Wei, primary, Han, Pei, additional, Fu, Jie, additional, Yu, Hang, additional, Xu, Hui, additional, Hu, Jia-Chun, additional, Lu, Jin-Yue, additional, Yang, Xin-Yu, additional, Zhang, Hao-Jian, additional, Bu, Meng-Meng, additional, Jiang, Jian-Dong, additional, and Wang, Yan, additional

Published
2023
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8. Metabolites Analysis of Anti-Myocardial Ischemia Active Components of Saussurea involucrata Based on Gut Microbiota—Drug Interaction

Author

Yu, Hang, primary, Fu, Jie, additional, Guo, Hui-Hui, additional, Pan, Li-Bin, additional, Xu, Hui, additional, Zhang, Zheng-Wei, additional, Hu, Jia-Chun, additional, Yang, Xin-Yu, additional, Zhang, Hao-Jian, additional, Bu, Meng-Meng, additional, Lin, Yuan, additional, Jiang, Jian-Dong, additional, and Wang, Yan, additional

Published
2022
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9. Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota

Author

Keranmu, Adili, primary, Pan, Li-Bin, additional, Fu, Jie, additional, Han, Pei, additional, Yu, Hang, additional, Zhang, Zheng-Wei, additional, Xu, Hui, additional, Yang, Xin-Yu, additional, Hu, Jia-Chun, additional, Zhang, Hao-Jian, additional, Bu, Meng-Meng, additional, Jiang, Jian-Dong, additional, Xing, Nian-Zeng, additional, and Wang, Yan, additional

Published
2022
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10. Hydroxyurea ameliorates atherosclerosis in ApoE-/- mice by potentially modulating Niemann-Pick C1-like 1 protein through the gut microbiota

Author

Yang, Xin-Yu, primary, Yu, Hang, additional, Fu, Jie, additional, Guo, Hui-Hui, additional, Han, Pei, additional, Ma, Shu-Rong, additional, Pan, Li-Bin, additional, Zhang, Zheng-Wei, additional, Xu, Hui, additional, Hu, Jia-Chun, additional, Zhang, Hao-Jian, additional, Bu, Meng-Meng, additional, Zhang, Xian-Feng, additional, Yang, Wei, additional, Wang, Jing-Yue, additional, Jin, Jing-Yu, additional, Zhang, Hui-Cong, additional, Li, Dong-Rui, additional, Lu, Jin-Yue, additional, Lin, Yuan, additional, Jiang, Jian-Dong, additional, Tong, Qian, additional, and Wang, Yan, additional

Published
2022
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11. The pharmacokinetic study of Saussurea involucrataliquid tonic, a traditional Chinese patent for inflammatory pain, in female rats in breastfeeding period

Author

Yu, Hang, Liu, Xing-Tong, Xu, Hui, Zhang, Zheng-Wei, Hu, Jia-Chun, Lu, Jin-Yue, Fu, Jie, Bu, Meng-Meng, Yang, Xin-Yu, Jiang, Quan, and Wang, Yan

Abstract

•The safety of Saussurea involucrataliquid tonic for postpartum medication was evaluated for the first time.•The pharmacokinetic characteristics and milk distribution of main components of Saussurea involucrataliquid tonic were conducted.•The quantitative method for detecting the main components of Saussurea involucrataliquid tonic in the matrix of milk by LC-MS/MS was established.

Published
2023
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12. Construction of A New Random Short Hairpin RNA Library Based on microRNA Context.

Author

Guo Q, Zhu N, Bu MM, Guo SC, Yan XJ, Chen Q, and Chen MH

Subjects
Genetic Vectors, Luciferases, Promoter Regions, Genetic, Gene Library, MicroRNAs genetics, RNA, Small Interfering genetics
Abstract

Objective To build an efficient random short hairpin RNA(shRNA)library. Methods shRNA expression vector was constructed with enhanced green fluorescent protein(EGFP)in the upstream of shRNA,driven by pol Ⅱ promoter(CMV).After the constructs were transfected into cells,the proteins were collected.The inhibition efficiency of shRNA was determined by Western blot and dual luciferase reporter system.After the shRNA expression vector was constructed with EGFP in the upstream of shRNA,driven by pol Ⅱ promoter(CMV),shRNA was further embedded into microRNA(miRNA)context.The constructs were transfected into cells,and then the inhibition efficiency of shRNA against target genes was evaluated by quantificational real-time polymerase chain reaction.According to the result of quantificational real-time polymerase chain reaction,a new random shRNA library was constructed based on miRNA context. Results shRNA downstream of a large transcript was transcripted efficiently by pol Ⅱ promoter(CMV).The efficiency of shRNA interference on target gene was improved when shRNA was embedded into miRNA context.Thus,we constructed a new random shRNA library sized 1.8×10 7 based on miRNA context.Conclusion We successfully constructed a new large random shRNA library.

Published
2017
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