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Your search keyword '"Bu, Yazhong"' showing total 29 results
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29 results on '"Bu, Yazhong"'

9. Fabrication and characteristics of multifunctional hydrogel dressings using dopamine modified hyaluronic acid and phenylboronic acid modified chitosan.

Author

Han, Yanting, Cao, Jing, Li, Man, Ding, Peng, Yang, Yujie, Okoro, Oseweuba Valentine, Sun, Yanfang, Jiang, Guohua, Shavandi, Amin, Nie, Lei, Bu, Yazhong, and Pietrasik, Joanna

Subjects
FABRICATION (Manufacturing), BIOPOLYMERS, HYDROGELS, HYALURONIC acid, DOPAMINE
Abstract

The healing of damaged skin is a complex and dynamic process, and the multifunctional hydrogel dressings could promote skin tissue healing. This study, therefore, explored the development of a composite multifunctional hydrogel (HDCP) by incorporating the dopamine modified hyaluronic acid (HA-DA) and phenylboronic acid modified chitosan (CS-PBA) crosslinked using boric acid ester bonds. The integration of HA-DA and CS-PBA could be confirmed using the Fourier transform infrared spectrometer and 1H nuclear magnetic resonance analyses. The fabricated HDCP hydrogels exhibited porous structure, elastic solid behavior, shear-thinning, and adhesion properties. Furthermore, the HDCP hydrogels exhibited antibacterial efficacy against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). Subsequently, the cytocompatibility of the HDCP hydrogels was verified through CCK-8 assay and fluorescent image analysis following co-cultivation with NIH-3T3 cells. This research presents an innovative multifunctional hydrogel that holds promise as a wound dressing for various applications within the realm of wound healing. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Succinic Ester‐Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration (Adv. Healthcare Mater. 5/2023)

Author

Zhu, Ye, primary, Zhang, Lining, additional, Duan, Wanglin, additional, Martin‐Saldaña, Sergio, additional, Li, Chaowei, additional, Yu, Hongwen, additional, Feng, Luyao, additional, Zhang, Xianpeng, additional, Du, Baoji, additional, Li, Guanying, additional, Zheng, Xifu, additional, and Bu, Yazhong, additional

Published
2023
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19. Lithium Loaded Octa‐Poly(Ethylene Glycol) Based Adhesive Facilitates Axon Regeneration and Reconnection of Transected Peripheral Nerves

Author

Bu, Yazhong, primary, Wang, Xianghai, additional, Li, Lixia, additional, Hu, Xiaofang, additional, Tan, Dandan, additional, Li, Zhenlin, additional, Lai, Muhua, additional, Qiu, Xiaozhong, additional, Sun, Feifei, additional, Wang, Hufei, additional, Yang, Fei, additional, Wu, Decheng, additional, and Guo, Jiasong, additional

Published
2020
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28. Cohesion mechanisms for bioadhesives

Author

Bu, Yazhong and Pandit, Abhay

Abstract

Due to the nature of non-invasive wound closure, the ability to close different forms of leaks, and the potential to immobilize various devices, bioadhesives are altering clinical practices. As one of the vital factors, bioadhesives' strength is determined by adhesion and cohesion mechanisms. As well as being essential for adhesion strength, the cohesion mechanism also influences their bulk functions and the way the adhesives can be applied. Although there are many published reports on various adhesion mechanisms, cohesion mechanisms have rarely been addressed. In this review, we have summarized the most used cohesion mechanisms. Furthermore, the relationship of cohesion strategies and adhesion strategies has been discussed, including employing the same functional groups harnessed for adhesion, using combinational approaches, and exploiting different strategies for cohesion mechanism. By providing a comprehensive insight into cohesion strategies, the paper has been integrated to offer a roadmap to facilitate the commercialization of bioadhesives.

Published
2021
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29. Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(β-hydroxyl amine) for Drug Delivery.

Author

Li D, Bu Y, Zhang L, Wang X, Yang Y, Zhuang Y, Yang F, Shen H, and Wu D

Subjects
Biodegradation, Environmental, Cell Line, Tumor, Cell Survival drug effects, Drug Carriers chemical synthesis, Drug Carriers chemistry, Endocytosis, Humans, Hydrogen-Ion Concentration, MCF-7 Cells, Oxidation-Reduction, Antibiotics, Antineoplastic pharmacology, Doxorubicin pharmacology, Drug Carriers pharmacology, Drug Liberation physiology, Hydroxylamines chemistry, Micelles, Neoplasms drug therapy
Abstract

Here we demonstrate a type of pH and reduction dual-sensitive biodegradable micelles, which were self-assembled by a cationic polymer in an aqueous solution. Due to tumor cells or tissues showing low pH and high reduction concentration, these micelles possessed specific tumor targetability and maximal drug-release controllability inside tumor cells upon changes in physical and chemical environments, but presented good stability at physiological conditions. CCK-8 assay showed that the DOX-loaded micelles had a similar cytotoxicity for MCF-7 tumor cells as free DOX, and blank micelles had a very low cytotoxicity to the cells. Fluorescent microscopy observation revealed that the drug-loaded micelles could be quickly internalized by endosomes to inhibit cancer cell growth. These results indicated these biodegradable micelles, as a novel and effective pH- and redox-responsive nanocarrier, have a potential to improve drug delivery and enhance the antitumor efficacy.

Published
2016
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