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972 results on '"Buchanan, T."'

1. ENGOT-en11/GOG-3053/KEYNOTE-B21: a randomised, double-blind, phase III study of pembrolizumab or placebo plus adjuvant chemotherapy with or without radiotherapy in patients with newly diagnosed, high-risk endometrial cancer

Author

Van Gorp, T., Cibula, D., Lv, W., Backes, F., Ortaç, F., Hasegawa, K., Lindemann, K., Savarese, A., Laenen, A., Kim, Y.M., Bodnar, L., Barretina-Ginesta, M.-P., Gilbert, L., Pothuri, B., Chen, X., Flores, M.B., Levy, T., Colombo, N., Papadimitriou, C., Buchanan, T., Hanker, L.C., Eminowicz, G., Rob, L., Black, D., Lichfield, J., Lin, G., Orlowski, R., Keefe, S., Lortholary, A., and Slomovitz, B.

Published
2024
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2. Cross-Sectional Brain-Predicted Age Differences in Community-Dwelling Middle-Aged and Older Adults with High Impact Knee Pain

Author

Johnson AJ, Buchanan T, Laffitte Nodarse C, Valdes Hernandez PA, Huo Z, Cole JH, Buford TW, Fillingim RB, and Cruz-Almeida Y

Subjects
knee osteoarthritis, high impact chronic pain, brain aging, experimental pain, psychosocial, Medicine (General), R5-920
Abstract

Alisa J Johnson,1,2,&ast; Taylor Buchanan,3,&ast; Chavier Laffitte Nodarse,1,2 Pedro A Valdes Hernandez,1,2 Zhiguang Huo,4 James H Cole,5,6 Thomas W Buford,3 Roger B Fillingim,1,2,7 Yenisel Cruz-Almeida1,2,7 1Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; 2Department of Community Dentistry & Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL, USA; 3Department of Medicine, University of Alabama, Birmingham, AL, USA; 4Department of Biostatistics, College of Public Health & Health Professions College of Medicine, University of Florida, Gainesville, FL, USA; 5Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK; 6Dementia Research Centre, Institute of Neurology, University College London, London, UK; 7Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA&ast;These authors contributed equally to this workCorrespondence: Yenisel Cruz-Almeida, University of Florida, PO Box 103628, 1329 SW 16th Street, Ste 5180, Gainesville, FL, 32608, USA, Tel +1 352-294-8584, Fax +1 352-273-5985, Email cryeni@ufl.eduPurpose: Knee OA-related pain varies in impact across individuals and may relate to central nervous system alterations like accelerated brain aging processes. We previously reported that older adults with chronic musculoskeletal pain had a significantly greater brain-predicted age, compared to pain-free controls, indicating an “older” appearing brain. Yet this association is not well understood. This cross-sectional study examines brain-predicted age differences associated with chronic knee osteoarthritis pain, in a larger, more demographically diverse sample with consideration for pain’s impact.Patients and Methods: Participants (mean age = 57.8 ± 8.0 years) with/without knee OA-related pain were classified according to pain’s impact on daily function (ie, impact): low-impact (n=111), and high-impact (n=60) pain, and pain-free controls (n=31). Participants completed demographic, pain, and psychosocial assessments, and T1-weighted magnetic resonance imaging. Brain-predicted age difference (brain-PAD) was compared across groups using analysis of covariance. Partial correlations examined associations of brain-PAD with pain and psychosocial variables.Results: Individuals with high-impact chronic knee pain had significantly “older” brains for their age compared to individuals with low-impact knee pain (p < 0.05). Brain-PAD was also significantly associated with clinical pain, negative affect, passive coping, and pain catastrophizing (p’s< 0.05).Conclusion: Our findings suggest that high impact chronic knee pain is associated with an older appearing brain on MRI. Future studies are needed to determine the impact of pain-related interference and pain management on somatosensory processing and brain aging biomarkers for high-risk populations and effective intervention strategies.Keywords: knee osteoarthritis, high impact chronic pain, brain aging, experimental pain, psychosocial

Published
2022

3. Risk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study

Author

Abdullah, Shaina, Abrahams, Fiona, Adams, Vincentius, Adnane, Fhima, Adoni, Sonia, Adoons, Dieketso Melitta, Africa, Veronique, Aguinaga, D, Akach, Susan, Alakram Khelawon, Prisha, Aldrich, George, Alesinloye, Olatunde, Aletta, Mathale Biniki, Alice, Mametja, Aphane, Tebogo, Archary, Moherndran, Arends, Felicity, Arends, Shireen, Aser, Munonde, Asmal, T, Asvat, Mohammed, Avenant, Theunis, Avhazwivhoni, Muvhali, Azuike, Magnolia, Baartman, Johanna, Babalwa, Dlava, Badenhorst, Johan, Badenhorst, Miranda, Badripersad, Bianca, Badul, Lalihla, Bagananeng, M, Bahle, Mncedisi, Balfour, Liezl, Baloyi, T C, Baloyi, S, Baloyi, Tinyiko, Baloyi, Tshepo Mpho, Banda, Thokozani, Barit, Shimon, Bartsch, Nicole, Bayat, Junaid, Bazana, Siyabulela, Beetge, Marlene, Bekapezulu, Nosindiso, Belebele, Rammala, Bella, Phala, Belot, Zanenkululeko, Bembe, Lindi Gladys, Bensch, Sonja, Beukes, Gishma, Bezuidenhout, Karla, Bhembe, Themba, Bikisha, N A, Bilenge, Ben, Bishop, Leesa, Biyela, Baphamandla, Blaauw, Cyntheola, Blaylock, Mark, Bodley, Nicola, Bogale, Power, Bokolo, Sibongile, Bolon, Stefan, Booysen, Mary, Booysen, Eldereze, Boretti, Lia, Borges, Paula, Boshoga, Millicent, Bosman, Natasha, Bosvark, Lucinda, Botes, Nicky, Botha, Adele, Botha, Chantall, Botha, Jana, botha, Chantall, Botha, Mandlakayise Irvin, Botha, Alet, Bradbury, Janet, Breakfast, Zandisile, Breed, Maria, Brenda, Molele, Brice, Moshito, Britz, Jolene, Brown, Amanda, Buchanan, T, Bucwa, Thozama, Burger, Crystelle, Busakwe, Ziyanda, Bushula, Nosiviwe, Buthelezi, Zinhle, Buthelezi, Dumsile, Buthelezi, Thubelihle, Buthelezi, Mpumelelo Basil, Buthelezi, Fundiswa Lidwina, Bux, Nadia, Buys, Christoff, Buys, Anneline, Caka, Ernestina, Canal, Armando Sanchez, Caroline, Sithole, Casper, Monrick, Cawood, Shannon, Cebisa, Oratile, Cele, Nothando, Cele, Sboniso, Cele, Sthembile Goodness, Chauke, Mkhacani, Chauke, Pinkie, Chelin, Nevil, Chen, Xiaohui, Chetty, Venmalla, Chetty, Kerisse, Cheu, Christinah, Chibabhai, Vindana, Chirima, Takudzwa, ChisaleMabotja, Mantwa, Chivenge, Charity, Choene, Ngoasheng, Choko, Mbali Nosisa, Choshi, Martin, Chowdhury, Sabbir, Christoforou, Anastacia, Chuene, S L S, Chueu, T S, Cilliers, Dale, Cilliers, Vanessa, Claassen, Marcel, Cloete, Jeané, Coelho, Chantelle, Coetzee, Carol, Coetzee, Hans Jurgens, Coetzee, Christine, Coetzee, Marelize, Coetzer, Dane, Coka, Sizwe, Colane, M, Combrink, Herkulaas, Conjwa, Songezo, Contrad, Colleen, Cornelissen, Faith, Cronje, Leezelle, Crouse, Christine, Dabi, Tshidi, Dandala, Ziyanda, Dangor, Ziyaad, Daniel, Gildenhuys, Daniel, Ngwana, Daumas, Alfred, Dauth, Madelein, David, Mongalo, Davids, Wayne, Daweti, Nozuko, Dawood, Halima, Dayile, Wandisa, De Bruin, B, De Klerk, Karin, De la Rosa, Tanya, de Nysschen, Marice, De vos, Marie, De Wet, Darien, Debising, Mohith, Deenadayalu, Darshan, Dekeda, Babalwa, Desiree, Mofokeng, Deysel, Annelise, Dhlamini, Abram, Diala, Makgethwa Dhlala, Diale, Mathapelo, Diketane, Bella, Dingani, Nosisa, Diniso, Siyabonga, Diphatse, Lesego, Diya, Anele, Dladla, Zihloniphile, Dladla, Nompumelelo, Dladla, Mlungisi, Dladla, Patience, Dlamini, Baphilie, Dlamini, Nonhlanhla, Dlamini, Linda, Dlamini, Nonzwakazi, Dlamini, Wendy, Dlamini, Ncomeka, Dlamini, Siyabonga, Dlamini, Nicodemus, Dlamini, Lebohang, Dlamini, Motshedise, Dlava, Babalwa Christine, Dlova, Phikiwe, Dlozi, Lindiwe, Doreen, Maenetja, Doyi, Vumile, Doyi, Athini, Du Plessis, Belinda, du Plessis, Johanna Aletta, du Plessis, Eddie, du Plessis, Nicolette, du Plessis, Karin, du Toit, Briette, du Toit, Narissa, Dube, Jabulile, Dubula, Athayanda, Duduzile, Msomi, Duiker, Sechaba, Duma, Unati Bongile, Duma, Kholiwe, Dunne, Kella, Dyantyi, Kholeka, Dyantyi, Avile, Dyasi, Simphiwe, Dyondzo, Chauke, Dyubhele, Phelisa, Dywili, B J, Edwards, Letitia, Eksteen, Madie, Ellis, Tersia, Ellis, Tia, Emmerson, Glenda, Enslin, Theusia, Epule, Odimula, Erasmus, Lana, Erick, Mathonsi, Etsane, Lerato, Eunice, Shimange, Fani, Zanele, Ferreira, Mariette, Finger-Motsepe, K L, Floris, Fabion, Fobo, Tseko, Fokotsane, Keresemetse, Fokwana, Duduzile Emmelda, Fords, Genevieve Marion, Fortein, Juanita, Fouche, Christine, Fourie, Rulandi, Frean, Andrew, Fredericks, Ludwig, Funda, Wandile, funjwa, kabelo, Futhane, Martha, Futuse, Amanda, Gabaediwe, Dora, Gabuza, Nonhlanhla, Galant, Janycke, Gama, Zanele, Gano, Thobile, Gardiner, Emma Cora, Gastrow, Henri, Gate, Kelly, Gaunt, Ben, Gavaza, Rikhotso, Gayi, Thapelo, Gcakasi, Nkosinathi, Gcobo, Nomusa, Geffen, Leon, Geldenhuys, S, George, Jenny, Gerber, Martha, Getyengana, Zolisa, Gigi, Nkululo, Gihwala, Radha, Gilliland, Mitchell, Gloria, Zandile, Glover, Elitia, Gokailemang, Ellen, Goosen, Suseth, Gopane, Maria, Gosa-Lufuta, Thandazile, Gosnell, Bernadett, Gouws, Sharleen, Govender, Christina, Govender, Raksha, Govender, Pearl, Govender, Sally, Govender, Roxanne, Govender, K, Govender, Savie, Govinden, Rashika, Gqabuza, Luphumlo, Gqaji, Nomthandazo, Gqetywa, Maneo, Green, Caroline, Green, Nathan, Green, Neera, Grobler, Hendrik, Groenwald, Pamela, Grootboom, Daniel, Gumede, Beatrice, Gumede, Nomonde, Gumede, Simphiwe, Gumede, Slindile, Gumede, Ntombikayise, Gumede, Zenande, Gxotiwe, Thandiswa, H L, Makhubela, Hadebe, Nonhlanhla, Hadebe, Skhumbuzo, Halkas, Christos, Hamer, Ansie, Hamida, Ebrahim, Hammond, Juan, Haniff, Sumayia, Hare, Annelise, Hattingh, lorinda, Hendricks, Thenjiwe, Henecke, Philip-George, Henly-Smith, Brends, Herselman, Glynis, Heymans, Ansie, Heyns, Chantel, Hlabahlaba, Golekane, Hlabangwane, Lucky, Hlamarisa, Simango, Hlanzi, Ntokozo, Hlela, Hlengiwe, Hlokwe, Katlego, Hlongwa, Thembinkosi, Hlongwana, Anele, Hlubi, Themba, Hobo, Tozama, Hopane, Nare Nathaniel, House, Mariska, Hudson, Catharina, Huysamen, Marinda, Indheren, Jezreen, Ingle, Samantha, Isaacs, Gavin, Isaacs, T S Thekiso, Itumeleng, Maringa, J van Rensburg, Karien, Jackson, Saloshni, Jacob, Neziswa, Jacobs, Burton, Jacobs, Tshireletso, Jacobs, Gugulethu, Jaftha, Mesadi, Jaji, Zimkhitha, Jali, Sibusiso, James, Gcobisa, January, Gillian, Jeke, Andiswa, Jeremiah, Laurent, Jeremiah, L S, Jhetam, Mubeen, John, Maureen, John, Chuene, Jola, Thandiwe, Jonas, Yolande, Jonas, Anovick, Juggernath, Amilcar, Kaba, Eileen, Kabo, Venetia, Kadi, Disebo, Kaizer, Karabo, Kambule, Moshaya Peter, Kapp, Lorraine, Kau, Tshepo, Keneth, Nchabeleng, Kgabi, O, Kgafela, Tebogo Audrey, Kgakgadi, Vincent, Kgaswe, Isabella, Kgathlane, Tsholofelo, Kgetha, Vuyelwa Julia, Kgomojoo, Mmaselloane, Kgoro, B, Kgosiemang, Christinah, Kgosiencho, Gloria, Khambula, Stephen, Khan, Ariffa, Khanare, Refemetswe, Khanyase, Ncamsile, Khanyile, Nokwethemba, Kharatsi, Fillip, Khawula, Simangele, Khohlakala, Themba, Khomo, Letitia, Khoza, Isabel, Khoza, Sinethemba, Khukule, Nombulelo, Khumalo, Busisiwe, Khumalo, Tracy, khumalo, Zinhle, Khumalo, Vuyelwa, Khumalo, Delisile, Khumalo, Lebohang, Khumalo, Boitumelo, Khumalo, Thuli, Khumalo, Gugu, Khuzwayo, Bongiwe, Khuzwayo, Thembhelihle, Kidson, Hennie, Kistan, Jesne, Klaas, Gugu, Klassen, Marilyn, Koeberg, Josehine, Koen, Marizel, Koena, Simphiwe, Kok, Ina, Kola, Imraan, Kolokoto, Karabo, Konar, Ramachandra, Kotsedi, Dr, Kotze, Jaline, Koupis, Martins, Kritzinger, Helen, Kruger, Marlize, Kruger, Henk, Kubayi, Tlangelani, Kubeka, Thabisile, Kubheka, Nonjabulo, Kubheka, Melusi, Kubheka, Sibusiso Clifford, Kubheka, Erol, Kumalo, Monica, Kunene, Thulani, Kunene, Siphilile Candy, Kunneke, Yvette, Kupa, R P, Kutama, Rachel, Kwakwazi, Nompumelelo, Kweyama, Lwanele, Labuschagne, Maureen, Labuschagne, Marina, Lakshman, Prabha, Lamani, Lungelo, Lamani, Thembela, Langa, Naomi, Langeni, Khangelani, Langeni, Aphelele, Langeni, Nwabisa Hazel, Langeveldt, Gena, Laubscher, Anchen, Le Roux, Laetitia, Leah, Magagane, Lebea, Collen, Lebea, Sello, Lebenya, Viyella Phumla Cynthia, Lebogang, Lorraine, Leboho, P K, Lee, Chantel, Lefakane, Kelebogile Rejoice, Legoabe, Zandile, Lekala, Patrick, Lekhoaba, Motsitsi, Lekunutu, Tanki Shadrack, Lerefolo, Galaletsang, Letebele, N, Lethoba, Tsepo Patric, Letlalo, Emission, Letlhage, Ofentse, Letshufi, D S V, Letsoalo, Dineo Fiona, Letsoalo, Seleka Jones, Letsoalo, Pennelope, Letwaba, Getrude, Linda, Sobekwa, Lipholo, Katleho, Litabe, Sabata, Lochan, Harsha, Lomax, Linda, Lombaard, Francina, Loots, Elmarie, Lourens, Ariana, Louw, Celeste, Louw, Rianna, Lubambo, Zikhona, Lubambo, Msebenzi Moises, Ludada, Gregory, Lukas, Michael, Lungu, Thembela, Lupindo, Nomvume, Lusenga, Emmah, Luthuli, Happiness, Luvuno, Zoleka Sylvia, M H, Gwangwa, Maarman, Mustafa, Mabaso, Buyisiwe, Mabaso, Cynthia, Mabitle, Morena, Mabogoane, Grace, Mabone, Kgakgamatso, Mabuza, Rueben, Mabuza, Velaphi, Madiseng, Mogantla, Madlala, Thobile, Madolo, Mashooase, Madonsela, Thabiso, Madubanya, Lesetsa, Maepa, Amukelani, Mafumana, Namhla, Mafumo, Caroline, Magadla, Pumeza, Magale, Viscah, Magaqa, Nompumelelo, Magda, Oberholzer, Magdeline, Rakgoale, Maggie, Tswai, Maginxa, Bongeka, Magoba, Cathrine Maite, Magongwa, Caroline, Magubane, Agretia, Magubane, Agretia Ntombizodwa, Magwai, R, Mahabane, D I, Mahabeer, Padmini, Mahadulula, Elsie, Mahanjana, Lungiswa, Maharaj, Amy, Mahlambi, Qedusiza, Mahlangu, Yvonne, Mahlangu, Lerato, Mahlangu, Ntombifikile, Mahlangu, Makhosazana, Mahlangu, Mahlatsi, Mahlasela, Penelope, Mahlatse, Thosago, Mahlobo, Regina, Mahole, Dikhing, Mahomed, Adam, Mahubane, Mapeu Debora, Mahume, Peter, Maifo, Lehlogonolo, Maimane, Vincent, Maimele, Petunia, Maine, Phakoe, Mainongwane, Patricia Senyanyathi, Majamani, Nomalungisa, Majozini, Amahle, Makalima, Noluthando, Makam, Nomfundo, Makamba, Khanyisa, Makan, R, Makarapa, Mashiane, Makgahlela, Malesela, Makgisa, Mogoiwa David, Makgomo, Makgoba, Makgopa, M A, Makhalema, Mabone, Makhanya, Lindokuhle Lizo, Makhanya, Philile Valentia, Makharaedzha, Tolerance, Makhathini, Nathi, Makhesi, Elizabeth, Makhubela, Cinile, Makhunga, Nkululeko Freedom, Makhupula, Nomalinge, Makhura, R R, Makola, Rangwato, Makuba, Zingisa, Makubalo, Asanda, Makumsha, Lonwabo, Makuya, George, Malaka, Levy Mmachuene, Malangeni, Themba, Malatji, M L, Malebana-Metsing, Pelonomi, Malek, Malek, Malevu, Luthando, Malgas, Juanita, Malgas, Dimakatso, Malope, Paul Makgasane, Malose, Monyeki, Maluleke, Katekani, Mambane, Kato, Mamorobela, Nthabiseng, Manamela, Kukami, Manana, Tshepo, Maneto, Sathiel, Manganye, Aron Kabelo, Mangena, Pheto, Mangoale, Anna, Mangozho, Tinotenda Florence, Manickchund, Pariva, Mankayi, Zandisile, Manning, Arthur, Manyaapelo, Kelebogile Manyaapelo, Manyane, Tabea, Manzana, Zoliswa, Manzini, Milton, Mapasa-Dube, Busisiwe, Maphumulo, Siboniso, Maphumulo, Ntombifuthi, Maponya, Sindy, Maponya, Khomotso Mumsy, Maponya, Napjadi, Maqubela, Lami, Maqubela, Lizeka, Maqungo, Vuyo, Marais, Marisa, Marais, Chantal, Maramba, Nondumiso, Mare, Annelize, Maredi, Madumetsa, Martins, Afikile, Marule, Johanna, Marumo, Refilwe, Masakona, N N, Masehla, Kedibone Vincentia, Maseko, Eric, Maselesele, Tshilidzi, Maselo, Mojalefa, Maseloa, M, Masemola, M E, Masemola, Thembi, Mashaba, Bella, Mashangwane, James, Mashao, Mantebele, Mashego, Shalom, Mashele, Lerato, Mashiane, Ester, Mashibini, Joyce, Mashilo, J, Mashiloane, Tumi, Mashishi, Charity, Mashiyi, Ngazibini, Mashudu, Khomola, Masindi, Aluwani, Maslo, Caroline, Masondo, Nduduzo, Masuku, Dumisile, Matamela, Cry, Matandela, Mirriam, Mathabela, Nontokozo, Mathabi, T, Mathe, Keitumetse, Mathebula, Mathabo, Mathebula, Catherine, Mathebula, Mdungazi Andres, Mathenjwa, Nqobizwe, Mathibe, Jane, Mathibela, Lebohang, Mathilda, Makwela, Mathiva, Khakhu, Mathobela, Mokgadi Alinah, Mathonsi, Fikile Pearl, Mathonsi, K P, Mathosa, Katlego, Matiwane, Noluvo, Matjeke, Emma, Matjiane, Bella, Matjila, Thabang, Matlala, Chidi, Matome, Petlo, Matoti, Nolusindiso, Matseliso, C, Matsemela, Dineo, Matsha, Phumeza, Matshediso, Gaalebale Prudence, Matshediso, Motsumi, Matshela, Esther, Mavuma, Bongeka, Mavundla, Pearl, Mavuso, Nomthandazo, Mawasha, Lovender, Mawelela, Rebecca, Mazibuko, Nelisiwe, Mazibuko, Phumlani, Mazubane, Lindiwe, Mbanjwa, Bavumile, Mbasa, Ayanda, Mbatha, Nosimilo, Mbatha, Zanele, Mbatha, Rudolph Zenzele, Mbedzi, Gift, Mbizi, Tatenda Trevor, Mbonambi, Khumbulani, Mboniswa, Nondumiso, Mbonisweni, Nomfanelo, Mbuilu, Jody, Mbulawa, Siyabonga, Mbutho, Zama, Mbuzi, Natasha, Mchunu, Nonkululeko, Mchunu, Cyprian, Mchunu, Nokuzola, Mchunu, Masesi Thandeka, Mciteka, Vuyokazi, Mdaka, Solly, Mdakane, Neho, Mdediswa, Siyabonga, Mdima, Melusi, Mdima Masondo, Nozipho, Mdindana, Siviwe, Mdleleni, Ntombizikhona, Mdletshe, Sibusiso, Mdoda, Gcobisa Precious, Mdolo, Ntombi, Mdontsane, Anele, Mehta, Ruchikas, Memela, Philile Rittah, Methuse, Masande, Metshile, Keatlaretse, Metuse, Pheliswa, Meyer, Anton, Meyer, Gavin, Meyer, Cameron, Mfazwe, Sisonke, Mfecane, Andiswa, Mfecane, Bongeka, Mfeka, Nelisiwe, Mgaga, Busisiwe, Mgauli, Thandiwe Portia, Mgedezi, Thembekile, Mgedezi, Vuyokazi, Mgevane, Kalipile, Mgiba, Bongni, Mgoduka, Babalwa, Mhlaba, Patrick, Mhlaba, Zeldah, Mhlanga, Ntombizodwa, Mhlinza, Vangile, Mhlongo, Nokuthula, Mhlongo, sibongiseni, Mhlotshana, Unamandla, Mikateko, Mabaso, Minnie, Helena, Mintoor, Karen, Miyeni, Bongi, M J, Mabelane, Mjethu, Rosy, Mkhize, Gloria, Mkhize, Mvuselelo, Mkhize, Ntokozo Siyabonga, Mkhize, Victoria, Mkhize, Nomkhosi, Mkhize, Nokuthula, Mkhwanazi, Mathini, Mkile, Nolwandle, Mkise, Kholofelo, Mkiya, Nokwandiso, Mkongi, Pearl, Mkungeka, Mnonopheli, Mlahleki, Hlomile, Mlibali, Nolukholo, Mlungwana, Sakhumzi, Mmachele, Jonas, Mmateka, Mashatole, Mmokwa, Molebatsi, Mmutlane, Thembisa, Mndebele, Zanele Olive, Mngomezulu, Nonhlanhla, Mnguni, Noluthando Millicent, Mngunyana, Pumza, Mngunyana, Nomxolisi, Mngxekeza, Ntombebongo, Mnisi, Zenzele, Mnqayi, Hlengiwe Precious, Mnqayi, Phumzile, Mntungwa, Thabiso, Mnyaka, Siya, Mnyakeni, Ntombikayise, Mnyamana, Vuyani, Mnyipika, Nomzingisi, Moabelo, Koena, Moatshe, Mmakgoshi Alseria, Mochaki-Senoge, Jennifer, Moche, Sharon, Mocwagae, Tebello, Modibane, Koeikantse, Modimoeng, Tebogo godfrey, Modisa, Obakeng, Modisane, Itumeleng, Modise, Olebogeng, Modjadji, Makaepeaa Flovia, Modupe, Sharon, Moeketsi, Maja, Moeketsi, Ntswaki, Moeng, Kereditse Kingsley, Mofamere, Naledi Nthabiseng, Mofokeng, Samuel, Mofokeng, Thabo, Mofomme, Jonas, Mogakane, Vicky, Mogale, Lehlohonolo, Mogapi, Audrey, Mogashoa, Thomas, Mogatla, Mphaka James, Mogoale, Kgaladi, Mohajane, Dikeledi Maggie, Mohapi, Nkuba, Mohatsela, Mthoamihla, Mohlala, Irene, Mohlala, Daphney, Mohlamonyane, Mpho, Mohutsiwa, Bonolo Millord, Moipone, Selemela, Moisi, Tshepang, Mojalefa, Nelly, Moji, Vuyo, Mokangwana, Buhle, Mokgabo, Matloa, Mokgaetji, Manaka, Mokgaotsi, Jane, Mokgoro, Neo Theodore, Mokhatla, Thalitha, Mokhele, Lerato Lovedalia, Mokhema, Sheila, Mokoena, Mamoya, Mokoena, Mojalefa, Mokome, Lleka, Mokone, Cynthia, Mokono, Ipeleng, Mokonyama, Thabiso, Mokori, Josiah, Mokuena, Dolores, Mokumo, Danny, Mokwena, Oddy, Mokwena, Kgaogelo, Mokwena, Kgantshi Sam, Mokwene, Lebogang, Molate, Thato Elliott, Molebalwa, Ditoche, Molefe, Boingotlo, Molehe, Kgopa Stanley, Moleme, Kgomotso, Moliane, Sarah, Moloi, Fanyana, Molorane, Retshepile Joseph, Molotsi, Glenda Tsholanang, Molukanele, Lerato, Monareng, Joy, Moncho, Thapelo, Monica, Modiadie, Monnane, Refilwe, Monqo, Andile, Montewa, Neo, Montsioa, Kgalalelo, Monyaki, Reitumetse, Monyane, Masekhobe Jeanett, Monyela, Lipson, Moodley, Yudeshan, Moodley, Kriesen, Moodley, Kaira, Mooka, Boitumelo Donald, Moonsamy, Prea, Moopanar, Simmi, Moore, David, Mophethe, Lineo, Moremedi, Tshegohatso, Moremong, Kealeboga, Morgan, Nthangeni, Moripa, Egma, Morris, Lulamile, Mosala, Me. A.M., Mosana, Thabo, Mosase, Alice, Mose, Yolanda, Mosehlo, Maponya, Moseki, Mothusi, Moshabe, Mojalefa David, Moshai, D A, Moshani, Mbulelo, Moshani, Pelisa, Mosima, Ledwaba, Mosima, Ezrom, Mosoma, M P, Motaung, Lebohang, Motaung, Mokete, Motaung Xhama, Thozama Charmain, Motha, Purine Khethiwe, Motimele, Lerato, Motimeng, Boitumelo, Motladiile, Shirley, Motlhabane, Otsile, Motlhamme, Joshua, Motloba, Mandla, Motse, Kagiso, Motshegoa, Sophia, Moutlana, Edward, Mouton, Irma, Moya, Zanele, Moyake, Nomonde, M P, Maja, Mpete, Jenny, Mpfuni, Luamba Meltha, Mphahlele, Seputule Mphahlele, Mphake, Mashadi, Mphanya, Ephraim Letlhogonolo, Mphaphuli, Mashudu, Mphela, Tebogo Chwene, Mpontshane, MS, Mqotyana, Thabile, Mqungquthu, Babalwa, Msane, Noluthando Busane, Mseleku, Malusi, Msibi, Sibusiso, Msibi, Mancele, Msibi, Thulisile, Msibi, Siyabonga Linda, Msiza, Clement Nhlanhla, Msomi, Lungelo, Mtatambi, Mandlenkosi, Mthathambi, Thembisa, Mthembu, December, Mthembu, Nhlahla, Mthembu, Fezile Mbali, Mthembu, Lungiswa, Mthethwa, Nompumelelo Petunia, Mthimkhulu, Khulekani, Mthuli, Lungani Percival, Mthunzi, Ashley, Mtolo, Xolani Sydney, Mtolo, Nomonde Precious, Mtshali, Linda, Mtwa, Neliswa, Mtyobile, Fezeka, Mtyobile, Kanyisa, Mudau, Mpfariseni, Muemeleli, Magwabeni, Mulaudzi, Isaac, Mulaudzi, Rebecca, Mulaudzi, Mhlelekedzeni, Muligwe, Dakalo Rejoyce, Muponda, Blessing, Mushadi, Mmbangiseni Stella, Mushid, M, Muthaphuli, Konanani, Muthavhine, J, Muthika, Mpho, Mvelase, Samkelisiwe, Mvelase, Vusi, Mwehu, Laurent Kayumba, Myaka, Thabile, myburgh, Magriet, Mzamo, Zimkhitha, Mzawuziwa, Fezeka, Mzini, Mfundo Lunga, Mzizana, Oscar, Mzobe, Ntokozo, Mzobe, Thokozile, Mzobe, Zamaswazi, Mzwandile, Mtimkulu, Naby, Fathima, Naicker, Keshnee, Naicker, Pregashnie, Naicker, Saroja, Naicker, Pershen, Naicker, Saiyen Virgil, Naidoo, Ria, Naidoo, Sam, Naidoo, Mergan, Naidoo, Kamalambal, Naidoo, Aroomugam, Naku, Sivuyile, Nakwa, Firdose, Nancy, Masoga, Nathan, Rita, Naude, Maritsa, Ncaza, Gcobisa, Ncaza, Aviwe, Ncha, Relebohile, Ncoyini, Yanelisa, Ncube, Snothile, Ndaba, Mrs, Ndaba, Vusumuzi, Ndaba, Mmapula, Ndawonde, Siziwe, Ndevu, Ziphozihle, Ndhlovu, Nonhlanhla Faith, Ndima, Simphiwe, Ndlela, Sindisiwe, Ndlela, Thobsile P, Ndlovu, Nobuhle, Ndlovu, Nwabisa, Ndlovu, Virginia Dipuo, Ndlumbini, Sombekhaya, Nduli, Khululiwe, Nduli, Priscilla Nontokozo, Ndwambi, Michael, Nel, Jeremy, Nel, Rina, Nel, Lizelle, Nemanashi, Ntsundeni florah, Nemudivhiso, Usinkhangwe Nyaphophi, Nemutavhanani, Joyce Nemutavhanani, Nene, Jabu, Nene, Xolani, Netshilonga, David, Netsianda, Rendani, Newton, Charmaine, Ngalo, Vuyo Leroy, Ngani, Ncumisa, Ngcakaza, Thabisa Monica, Ngcobo, Thamela, Ngcobo, Trulove Nonhlanhla, Ngcobo, Richards, Ngcobo, Gcinile, Ngcobo, Guguletu, Ngetu, Thozama, Ngewu, Pinkie, Ngobeni, Tshepo, Ngobeni, Providence, Ngobeni, Khanyisile, Ngobeni, Prudence, Ngobese, Thembisile, Ngomane, Tracy, Ngondo, Nolusindiso, Ngubane, Nokukhanya, Ngubane, Sithembiso, Nguse, Ntombizodwa Praxedise, Ngwane, Tholakele, Ngwasheng, Elizabeth, Ngwenya, Siphamandla, Ngwenya, Gugu, Ngwenya, Nomthandazo, Ngwenya, Themba, Ngwenya, Eva, Ngxola, Zintlanu, Nhabe, Tshegofatso, Nhlabathi, Jabulile, Nhlangwana, Ishmael, Nhlapo, Sithembile, Nick, Matlala, Niemand, Vicky, Nienaber, Carina, Nix, Louise, Njikelana, Chumisa, Njomi, Masiza, Nkabinde, Lucia, NKABINDE, M, Nkabiti, Boitumelo, Nkabule, Gugu, Nkadimeng, Mankopodi, Nkanjeni, Nonkanyiso, Nkatlo, Palesa Portia, Nkewana, Bongani, Nkhwashu, Audrey, Nkoana, Ngokoana, Nkoane, Mmathapelo, Nkogatse, M, Nkomo, Fezile, Nkomo, Ntando, Nkonyane, Nontobeko, Nkosi, Sydney, Nkosi, Ntombikayise, Nkosi, Phumzile, Nkosi, Ntombifuthi, NKOSI, TINTSWALO, Nkosi, ML, Nkosi, Godfrey, Nkosi, Amukelani, Nkosi, Fikile Vinoliah, Nkosi, Mbali, Nkosi, Nomcebo Lucia, Nkosi, Siphokazi, Nkuhlu, Amanda, Nkumane, Phumzile, Nkuna, Malebo, Nkwakwha, Wendy, Noge, Sesi, Nolte, Elizabeth, Nomawabo, Peko, Nombita, Malibongwe, Nophale, Nandipha, Nothnagel, Jeanetta, Novokoza, Bongiwe, Nqaphi, Zanele, Nqondo, Thobekile, Nqwelo, Siphokazi, N S, Nkoana, Ntabeni, Sindiswa, Ntabeni, Mr, Ntampula, mawethu, Ntebe, Mthutuzeli, Ntela, Mokwabo, Ntimbane, Hezekiah, Ntintsilana, Xolisa, Ntleki, Patrick, Ntobela, Zanele, Ntombela, Bandile, Ntombela, Zamaswazi, Ntombela, Khonelihle Zandile, Ntombela, Praisegod Samkelo Thobani, Ntonintshi, Lindiwe, Ntseane, Dipuo, Ntseane, Thobeka, Ntsham, Xolelwa, Ntshele, Mbalenhle, Ntshewula, Amanda, Ntsoko, Zinzi, Ntsoto, Athini, Ntuli, Nomsa, Ntuli, Nokwazi, Ntuli, Nomvula, Ntuli, Andrew Diffar, Ntuli, Faith, Nurnberger, Margrit, Nxala, Ntsikelelo, Nxasane, Sithandiwe, Nxumalo, Thanda, Nyathi, Xolani, Nyawula, Nontobeko, Nzama, Nhlakanipho, Obed, Maila Nkuneng, Ogwal, Florence, Olifant, Maureen, Oliphant, B, Olive, Monota, Olyn, Kagisho, Omoighe, Raymond, One, Phumeza, Oscar, Ratombo, Owen, Nkuna, P, Mailula, Padayachee, Nalini, Padayachy, Vasaily, Pakade, Ntombizakhe, Palime, Mosiuoa, Palisa, Jane, Parker, Arifa, Parkies, Lesenyeho, Parrish, Andy, Patel, Nilesh, Pather, Anastasia, Patience, Mkhombo Tsakani, Patzke, Marisa, Pawuli, Akhumzi, Pelako, Ntandokazi, Penrose, Phaswana Sibasa, Peppeta, Litha, Pershad, Santosh, Pertunia, Makheda, Pertunia, Nkuna, Perumal, Dane, Peter, Mongameli, Peters, Justin, Petlane, Vatiswa, Petrus, Harideen, Phahladira, Kgomotso, Phakisa, Matebesi John, Phale, R, Phathela, Livhuwani, Phillip, Sekate Daniel, Phiri, Beverly, Phiri, Mapule Precious, Phokane, Thapelo, Phokoane, Frank, Pholosho, Moele, Phooko, Sekoro, Phooko, Sekodi Geoffrey, Phutiane, Maponya, Pillay, Faiza, Pillay, Melanie, Pillay, Sayuri, Pillay, C R, Plaatjie, Zikhona, Pootona, James, Potgieter, Samantha, Potgieter, Marius, Precious, Mulaudzi Mulatedzi, Pretorius, Paul Janus, Prozesky, Hans, Pule, Mokhethi, Punwasi, Jayshina, Putzier, Dot, Qankqiso, Lutho, Qebedu, Siphokazi, Qhola, Phozisa, Qotoyi, Ntombesithathu, Qotso, Sipho Victor, Qwabe, Zanele, Rabie, Helena, Rabothata, Phoebe, Rachoene, Christina, Radana, Mteteleli, Radebe, Maria, Radebe, Dr. Valentino, Radebe, Nonkululeko, Radinne, Ella, Raduvha, Sherly, Raghunath, Shamintha, Rajagopaul, Claudine, Rakgwale, Mary, Ralethe, Malumbete Michael, Ralimo, Kenneth, Ramafoko, Motlalepule, Ramagoma, Maduvhahafani, Raman, Charlotte, Ramavhuya, Dr, Rambally, Molly, Ramdeen, Nivasha, Ramdin, Tanusha, Rameshwarnath, Sharita, Ramkillawan, Yeishna, Ramotlou, Rampedi, Faith, Rampersad, Vijayluxmi, Ramuima, Avhashoni, Ranone, Noluthando, Rapasa, Mabohlale Portia, rapelang, Mpharoane, Raphaely, Nika, Rashokeng, Lesiba, Rashopola, Caroline, Ratau, Tebogo, Ratau, M, Ratshili, Mpfariseni David, Rautenbach, Elmari, Ravele, Rofhiwa, Reachable, Johannes, Rebecca, Peta Mmalahla, Reddy, Kessendri, Redfern, Andrew, Reed, Robertha, Rees, Mumsy, Reji, Dr, Reubenson, Gary, Rewthinarain, Veena, Rheeder, Paul, Rhulani, Nkonayani, Richard, Mufamadi, Rikhotso, J S, Rikhotso, Shatimone Beverley, Robert, Lavhelani Ndivhaleni, Roto, Noncedo, Ruder, Gideon, Rugnath, Kapil, Ruiters, Lizette, Ruiters, Mina, Russell, Sue, Ruwiza, Lynn, R Y, Molokoane, Saaiman, Mandy, Sabela, Emmanuel, Sadiq, Lerato, Saki, Litha, Salambwa, Hyppolite, Samjowan, Menitha, Samodien, Nazlee, Samuel, Rakgolele, Sandile, Fakudze, Sanelisiwe, Cekuse, Sani, Mandlankosi, Sawuka, Simangele, Schoeman, Lelani, Scholts, Magriet, Schroder, Ronel, Sebalabala, Mamotetekoane, Sebati, Selwalenkwe Collet, Seboko, Jacoline, Sebuthoma, Wilheminah, Segami, Annah, Segokotlo, Ruth, Sehloho, MR, Seisa, Khutjo, Sekgobela, Antony, Sekhosana, Monica, Sekonyela, John, Sekoto, Mpho, Sekulisa, Naledi, Sekwadi, Mokgadi Vanessa, Selaelo, Lebogo, Selatlha, Johannes, Selekolo, Kgomotso, Selfridge, William, Semenya, Lucy, Sengakane, Ivy, Sengata, Masabata, Sentle, Petronella, Seoketsa, Malebo, Seonandan, Pratheesha, Serumula, Thomas Mambushi, Setheni, Nkululeko, Setlale, Refiloe, Setlhodi, Tumediso, Setlhodi, Barbara, Setloghele, Robert, Sewpersad, Aarthi, Sewpersadh, Ryan, Shabalala, Phumlile, Shabangu, Owen, Shabangu, Kungesihe, Shabangu, Harriet Sbonangaye, Shabangu, Thokozani, Shadi, Clifford, Shaik, Hasifa, Shale, Tseliso, Shandu, Qedani, Shandu, Nomvelo, Shange, Ntswaki Marcia, Shenxane, Abongile, Sherriff, A, Shezi, Sebenzile, Shezi, Thenjiwe, Shihangule, Scally, Shikwambana, Cheyeza, Shoba, Lungisani, shokane, Kamogelo, Sibande, Nora, Sibeko, Lydia, Sibeko, Xolani, Sibiya, Zanele, Sibiya, Mncedisi, Sibuta, Sphamandla, Sifumba, Thembakazi, Sigcau, Sipho, Sigila, Lutho, Sihentshe, Kayakazi, Sihlangu, Bongani, Sikhakhane, Daisy, Sikhakhane, Shaun Nhlanhla, Siko, Mbali, Sikonje, Sipho, Simanga, Khumbulekile, Simango, Nomsa, Simela, Thulisile, Simelane, Ntombikayise, Singh, Sashah, Singh, Marjorie, Singh, Ragani, Singh, Shash, Singh, Anita, Sithole, Hitekani, Sithole, Senzekile, Sithole, Ntokozo Danielle, Sithole, Koketso Maxwell, Situma, Jonnie, Sivraman, Annie, Siwela, Katekani, Siyewuyewu, Nonqubela, Sizeka, Maweya, Siziba, Nonceba, Skhosana, Andrew, Skhosana, Khanyisile, Skhosana, Rorisang, Skoko, Tandiwe, Slabbert, Sunet, Smangaliso, Ntombela, Smedley, Christine, Smit, Lydia, Smit, Natassia, Smit, Lizelle, Smit, Michelle, Smith, Fasie, Smith, Lizzie, Smith, Sunell, Smith, Cassius, Smuts, Stefan, Sofe, Ayanda, Solomon, Khobane, Solomon, L J, Sombani, chauke, Songca, Richard, Sontamo, Anga, Soorju, Supriya, Sopazi, Zubenathi, Soqasha, Brian, Sosibo, Bongiwe, Sotsaka, Ntsika, Soula, Mandy, Spoor, Simon, Stacey, Sarah, Stali, Asanda, Stephina, Mutele Mmboniseni, Steup, Myra, Steven, Sinoxolo, Stevens, AW, Stevens, Vincent, Steyn, Dewald, Steyn, Bianca, Stocks, Pat, Stolk, Henk, Stoltz, Alida, Strehlau, Renate, Stroebel, Anneke, Strydom, Loraine, Strydom, Jean-Marie, Strydom, Anton, Strydom, Ursula, Sunnyraj, Midhu, Swana, Nwabisa, Swanepoel, Winnie, Swanepoel, Suzan, Swartbooi, Elsie, Swartz, Estley Swartz, Syce, Casandra, T E, Shihambi, Tabane, Joyce, Tabane, N E, Tawana, Mrs, Tebello, Ntene, Tembe, Siphosetu Wiseman, Terblanche, Samantha, Thabede, Ntombifuthi, Thabelo, Nkhumeleni, Thabethe, Sibusiso, Thabo George, Lekhanya, Thare, Keorapetse, Thebogo, Makofane, Thekiso, Lerato, Theko, Lloyd, Themba, Celimphilo Zandi, Theron, Danie, Theron, Henda, Theron, Ilze, Thingathinga, Thandiwe, Thlabadira, M M, Thoka, Dikeledi, Thokwana, Zanele, Thom, Gustav, Thubakgale, Mamphot Joel, Thwala, Theodora, Thys, P, Tieho, Monethi, Timothy, Matodzi, Tintswalo, Ndlovu, Tivana, Babalwa, Tladi, Molefi, Tokota, Bongiwe, Toni, Simthandile, Torres, Ariel, Toubkin, Mande, Tsatsi, Marinda, Tshabalala, Khanyisile, Tshamase, Nozibele, Tshefu, Gontse, Tshegofatjo, Makgoga, Tshikomba, Given, Tshilo, Thapelo, Tshira, Lerato, Tshirado, S T, Tshisikule, Maipfi, Tsoke, G, TSOKE, N, Tsoko, Alatha, Tsotetsi, Mosele, Tsubella, Sandeva, Tuswa, Noxolo, Tutse, Maipato, Tutu, Nomayenzeke, Twala, Sphephelo, Twala, Nhlanhla, Twala, Simphiwe, Ubisi, John, Unathi, Tefo, Van Aswegen, A, van der Merwe, Marietjie, van der Merwe, Trudie, van der Plank, Patience, van der Spuy, Elmarie, Van Der Westhuizen, Linda, Van Der Westhuizen, Adele, van der Westhuizen, Talana, van der Westhuyzen, Mene, Van Dyk, Thea, van Heerden, Ingrid, van Jaarsveld, Ryno, Van Lill, M, van Niekerk, Heidi, van Niekerk, Ben, van Rensburg, Amanda, van Schallwyk, Judy, Van Sensie, Zeitschke Yarnrich, van Vuuren, Magda, van Vuuren, Cloete, Vandu, Olga Funiswa, Vane, Mandisa, VanZyl, Lucia, Variava, Ebrahim, Veerus, Mariam, Velapi, Nokhwezi, Veleko, Sebina, Velezantsi, Z, Venter, Retha, Vergottini, Corlia, Vermeulen, Inga, Vidah, Liabara Lufuluvhi, Vilakazi, Bongani, Vilakazi, Treasure N, Vilakazi, Mbalenhle Precious, Viljoen, Karen, Viljoen, Werner, Volschenk, Zuretha, Vos, Angelo, V V, Matlala, Walters, Jacques, Webb, Kate, Welsh, John, Wessels, D, Wheller, Judy, White, Fundile, White, Priscilla, Whyte, Carmen, Willemse, Ansie, William, Sape, Williams, Daniel, Williams, Kamielah, Williams, Mercia, Williamson, Anne, Wilson, Cherade, Wolff, Boipelo, Wray, Michelle, Xaba, Ntombizonke B, Xaba, Thabang Jabulani, Xiniwe, Thanks, Xoliswa, Mtshali, Xulu, Funokwakhe, Xulu, Gibson, Yam, Sandlakazi, Zakhura, NM, Zareloa, Mashela, Zinto, Sive, Zinziswa, Dyibeni, Ziselo, Lulamile, Zitha, Zakhele, Zitha, Emmanuel, Zokufa, Anele, Zondi, Innocent, Zondi, Sikhumbuzo Bernard, Zondi, Sbuyi, Zondi, Thulani, Zongola, Wandiswa, Zühlke, Liesl, Zulu, Zandile, Zulu, Lungelo, Zulu, Thandeka, Zulu, Slindili, Zulu, Nkosinathi, Zuma, Angel, Zungu, Precious, Zungu, Pamela, Zungu, Melusi, Zungu, Priscilla, Zwakala, Bongo Lihle, Zwane, Antonia, Zwane, Promise, Zwane, Muziwendoda, Zwane, Hlengiwe Priscila, Zwane, Nomgcobo, Jassat, Waasila, Cohen, Cheryl, Tempia, Stefano, Masha, Maureen, Goldstein, Susan, Kufa, Tendesayi, Murangandi, Pelagia, Savulescu, Dana, Walaza, Sibongile, Bam, Jamy-Lee, Davies, Mary-Ann, Prozesky, Hans W, Naude, Jonathan, Mnguni, Ayanda T, Lawrence, Charlene A, Mathema, Hlengani T, Zamparini, Jarrod, Black, John, Mehta, Ruchika, Chikobvu, Perpetual, Muvhango, Ntshengedzeni, Strydom, Riaan, Adelekan, Tsholofelo, Mdlovu, Bhekizizwe, Moodley, Nirvasha, Namavhandu, Eunice L, Venturas, Jacqueline, Magula, Nombulelo, and Blumberg, Lucille

Published
2021
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7. Deep Brain Stimulation and Levodopa Affect Gait Variability in Parkinson Disease Differently

Author

Su, ZH, Patel, S, Gavine, B, Buchanan, T, Bogdanovic, M, Sarangmat, N, Green, AL, Bloem, BR, FitzGerald, JJ, and Antoniades, CA

Subjects
Anesthesiology and Pain Medicine, All institutes and research themes of the Radboud University Medical Center, Neurology, Neurology (clinical), General Medicine, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
Abstract

Background Both dopaminergic medication and subthalamic nucleus (STN) deep brain stimulation (DBS) can improve the amplitude and speed of gait in Parkinson disease (PD), but relatively little is known about their comparative effects on gait variability. Gait irregularity has been linked to the degeneration of cholinergic neurons in the pedunculopontine nucleus (PPN). Objectives The STN and PPN have reciprocal connections, and we hypothesized that STN DBS might improve gait variability by modulating PPN function. Dopaminergic medication should not do this, and we therefore sought to compare the effects of medication and STN DBS on gait variability. Materials and Methods We studied 11 patients with STN DBS systems on and off with no alteration to their medication, and 15 patients with PD without DBS systems on and off medication. Participants walked for two minutes in each state, wearing six inertial measurement units. Variability has previously often been expressed in terms of SD or coefficient of variation over a testing session, but these measures conflate long-term variability (eg, gradual slowing, which is not necessarily pathological) with short-term variability (true irregularity). We used Poincaré analysis to separate the short- and long-term variability. Results DBS decreased short-term variability in lower limb gait parameters, whereas medication did not have this effect. In contrast, STN DBS had no effect on arm swing and trunk motion variability, whereas medication increased them, without obvious dyskinesia. Conclusions Our results suggest that STN DBS acts through a nondopaminergic mechanism to reduce gait variability. We believe that the most likely explanation is the retrograde activation of cholinergic PPN projection neurons.

Published
2023

10. SARS-CoV-2 wildlife surveillance in Ontario and Québec

Author

Greenhorn, JE, primary, Kotwa, JD, additional, Bowman, J, additional, Bruce, L, additional, Buchanan, T, additional, Buck, PA, additional, Davy, CM, additional, Dibernardo, A, additional, Flockhart, L, additional, Gagnier, M, additional, Hou, A, additional, Jardine, CM, additional, Lair, S, additional, Lindsay, LR, additional, Massé, A, additional, Muchaal, PK, additional, Nituch, LA, additional, Sotto, A, additional, Stevens, B, additional, Yip, L, additional, and Mubareka, S, additional

Published
2022
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11. Teacher Beliefs and Practices Survey: Operationalising the 1997 NAEYC Guidelines

Author

Kim, Kyung-Ran and Buchanan, T. K.

Abstract

This study examined the psychometric properties of a revised measurement, the "Teacher Beliefs and Practices Survey" (TBPS), devised for teachers of three- to five-year-old children. This measure was designed to reflect the concepts of developmentally appropriate practices (DAP) as presented in the revised 1997 National Association for the Education of Young Children guidelines. Reliability was examined using an internal consistency method. Validity of the measure was examined in its content, criterion and construct. The factors uncovered in the survey supported the content validity because the factors matched the important concepts of DAP in the revised guidelines. To examine concurrent criterion-related validity, teachers' observed practices were compared to their self-reported beliefs and practices. The low but significant correlation between the TBPS score and a theoretically related measure, the "Teacher Educational Attitude Scale," supported construct validity. Considering the psychometric properties, the TBPS appears to be a promising measure for critically examining teachers' beliefs about and practices of DAP. (Contains 2 tables.)

Published
2009
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17. Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at root s(NN)=5.02 TeV

Author

Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Bergauer, T., Dragicevic, M., Ero, J., Del, Valle, Escalante, A., Flechl, M., Fruhwirth, R., Jeitler, M., Krammer, N., Kratschmer, I, Liko, D., Madlener, T., Mikulec, I, Rad, N., Schieck, J., Schofbeck, R., Spanring, M., Waltenberger, W., Wulz, C-E, Zarucki, M., Drugakov, V, Mossolov, V, Gonzalez, Suarez, J., Darwish, M. R., Wolf, De, E. A., Croce, Di, Janssen, D., Kello, X., Lelek, T., Pieters, A., Sfar, M., Rejeb, H., Van, Haevermaet, Van, Mechelen, Van, Putte, Van, Remortel, Blekman, N., Bols, F., Chhibra, E. S., D'Hondt, S. S., Clercq, De, Lontkovskyi, J., Lowette, D., Marchesini, S., Moortgat, I, Python, S., Tavernier, Q., Van, Doninck, Van, Mulders, Beghin, P., Bilin, D., Clerbaux, B., Lentdecker, De, Delannoy, G., Dorney, H., Favart, B., Grebenyuk, L., Kalsi, A., Moureaux, A. K., Popov, L., Postiau, A., Starling, N., Thomas, E., L. V., Velde, Er, Vanlaer, C., Vannerom, P., Cornelis, D., Dobur, T., Khvastunov, D., Niedziela, I, Roskas, M., Skovpen, C., Tytgat, K., Verbeke, M., Vermassen, W., Vit, B., Bruno, M., Caputo, G., David, C., Delaere, P., Delcourt, C., Giammanco, M., Lemaitre, A., Prisci, V, Aro, J., Saggio, A., Vischia, P., Zobec, J., Alves, G. A., Silva, Correia, G., Hensel, C., Moraes, A., Batista Das Chagas, Belchior, E., Carvalho, W., Chinellato, J., Coelho, E., Costa, Da, E. M., Silveira, Da, Damiao, G. G., De Jesus, D., Martins, De Oliveira, C., Souza, De, Fonseca, S., Malbouisson, H., Martins, J., Figueiredo, Matos, D., Jaime, Medina, M., Almeida, De, Melo, M., Herrera, Mora, C., Mundim, L., Nogima, H., Prado Da Silva, Teles, W. L., Rebello, P., Rosas, Sanchez, L. J., Santoro, A., Sznajder, A., Thiel, M., Tonelli, Manganote, E. J., Da Silva De Araujo, Torres, F., Pereira, Vilela, A., Bernardes, C. A., Calligaris, L., Fern, ez Perez Tomei, Gregores, T. R., Lemos, E. M., Mercadante, D. S., Novaes, P. G., Padula, S. F., S, Ra, S., Aleks, Rov, Antchev, A., Hadjiiska, G., Iaydjiev, R., Misheva, P., Rodozov, M., Shopova, M., Sultanov, M., Bonchev, G., Dimitrov, M., Ivanov, A., Litov, T., Pavlov, L., Petkov, B., Petrov, P., Fang, A., Gao, W., Yuan, X., Ahmad, L., Hu, M., Wang, Z., Chen, Y., Chen, G. M., Chen, H. S., Jiang, M., Leggat, C. H., Liao, D., Liu, H., Spiezia, Z., Tao, A., Yazgan, J., Zhang, E., Zhang, H., Zhao, S., Agapitos, J., Ban, A., Levin, G., Li, A., Li, J., Li, L., Mao, Q., Qian, Y., Wang, S. J., Wang, D., Xiao, Q., Avila, M., Cabrera, C., Florez, A., Gonzalez, Hern, C. F., Ez, Segura, Delgado, M. A., Mejia, Guisao, Ruiz, Alvarez, J. D., Salazar, Gonzalez, C. A., Vanegas, Arbelaez, Godinovic, N., Lelas, N., Puljak, D., Sculac, I, Antunovic, T., Kovac, Z., Brigljevic, M., Ferencek, V, Kadija, D., Mesic, K., Roguljic, B., Starodumov, M., Susa, A., Ather, T., Attikis, M. W., Erodotou, A., Ioannou, E., Kolosova, A., Konstantinou, M., Mavromanolakis, S., Mousa, G., Nicolaou, J., Ptochos, C., Razis, F., Rykaczewski, P. A., Saka, H., Tsiakkouri, H., Finger, D., Finger, M., r. M., J, Kveton, A., Tomsa, J., Ayala, E., Jarrin, Carrera, E., Mahmoud, M. A., Mohammed, Y., Bhowmik, S., Antunes De Oliveira, Carvalho, A., Dewanjee, R. K., Ehataht, K., Kadastik, M., Raidal, M., Veelken, C., Eerola, P., Forthomme, L., Kirschenmann, H., Osterberg, K., Voutilainen, M., Garcia, F., Havukainen, J., Heikkila, J. K., Karimaki, V, Kim, M. S., Kinnunen, R., Lampen, T., Lassila-Perini, K., Laurila, S., Lehti, S., Linden, T., Siikonen, H., Tuominen, E., Tuominiemi, J., Luukka, P., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., Monchenault, De, Hamel, G., Jarry, P., Leloup, C., Lenzi, B., Locci, E., Malcles, J., R, Er, Rosowsky, J., Sahin, A., Savoy-Navarro, M. O., Titov, A., Yu, M., Ahuja, G. B., Amendola, S., Beaudette, C., Bonanomi, F., Busson, M., Charlot, P., Diab, C., Falmagne, B., Cassagnac, De, Granier, R., Kucher, I, Lobanov, A., Perez, Martin, C., Nguyen, M., Och, O, Paganini, C., Rembser, P., Salerno, J., Sauvan, R., Sirois, J. B., Zabi, Y., Zghiche, A., Agram, A., J-L, Rea, Bloch, J., Bourgatte, D., Brom, G., J-M, Chabert, Collard, E. C., Conte, C., Fontaine, E., J-C, Gele, Goerlach, D., Grimault, U., Bihan, Le, A-C, Tonon, Van, Hove, Gadrat, P., Beauceron, S., Bernet, S., Boudoul, C., Camen, G., Carle, C., Chanon, A., Chierici, N., Contardo, R., Depasse, D., Mamouni, El, Fay, H., Gascon, J., Gouzevitch, S., Ille, M., Jain, B., Laktineh, Sa, Lattaud, I. B., Lesauvage, H., Lethuillier, A., Mirabito, M., Perries, L., Sordini, S., Torterotot, V, Touquet, L., G. V., Donckt, Er, Viret, M., Toriashvili, S., Tsamalaidze, T., Autermann, Z., Feld, C., Klein, L., Lipinski, K., Meuser, M., Pauls, D., Preuten, A., Rauch, M., Schulz, M. P., Teroerde, J., Erdmann, M., Fischer, M., Ghosh, B., Hebbeker, S., Hoepfner, T., Keller, K., Mastrolorenzo, H., Merschmeyer, L., Meyer, M., Millet, A., Mocellin, P., Mondal, G., Mukherjee, S., Noll, S., Novak, D., Pook, A., Pozdnyakov, T., Quast, A., Radziej, T., Rath, M., Reithler, Y., Roemer, H., Schmidt, J., Schuler, A., Sharma, S. C., Wiedenbeck, A., Zaleski, S., Flugge, S., Ahmad, G., Haj, W., Hlushchenko, O., Kress, T., Muller, T., Nowack, A., Pistone, C., Pooth, O., Roy, D., Sert, H., Stahl, A., Martin, Aldaya, M., Asmuss, P., Babounikau, I, Bakhshiansohi, H., Beernaert, K., Behnke, O., Martinez, Bermudez, A., Bin, Anuar, Borras, A. A., Botta, K., Campbell, V, Cardini, A., Connor, A., Rodriguez, P., Consuegra, S., Contreras-Campana, C., Danilov, V, Wit, De, Defranchis, A., Pardos, M. M., Diez, C., Damiani, Dominguez, D., Eckerlin, G., Eckstein, D., Eichhorn, T., Elwood, A., Eren, E., Banos, Estevez, L. I., Gallo, E., Geiser, A., Grohsjean, A., Guthoff, M., Haranko, M., Harb, A., Jafari, A., Jomhari, N. Z., Jung, H., Kasem, A., Kasemann, M., Kaveh, H., Keaveney, J., Kleinwort, C., Knolle, J., Krucker, D., Lange, W., Lenz, T., Lidrych, J., Lipka, K., Lohmann, W., Mankel, R., Melzer-Pellmann, I-A, Meyer, A. B., Missiroli, M., Mnich, J., Mussgiller, A., Myronenko, V, Adan, Perez, D., Pflitsch, S. K., Pitzl, D., Raspereza, A., Saibel, A., Savitskyi, M., Scheurer, V, Schutze, P., Schwanenberger, C., Shevchenko, R., Singh, A., Ricardo, Sosa, R. E., Tholen, H., Turkot, O., Vagnerini, A., Van De Klundert, Walsh, M., Wen, R., Wichmann, Y., Wissing, K., Zenaiev, C., Zlebcik, O., Aggleton, R., Bein, R., Benato, S., Benecke, L., Dreyer, A., Ebrahimi, T., Feindt, A., Frohlich, F., Garbers, A., Garutti, C., Gonzalez, E., Gunnellini, D., Haller, P., Hinzmann, J., Karavdina, A., Kasieczka, A., Klanner, G., Kogler, R., Kovalchuk, R., Kurz, N., Kutzner, S., Lange, V, Lange, J., Malara, T., Multhaup, A., Niemeyer, J., Reimers, C. E. N., Rieger, A., Schleper, O., Schumann, P., Schw, S., T, J., Sonneveld, J., Stadie, H., Steinbruck, G., Vormwald, B., Zoi, I, Akbiyik, M., Baselga, M., Baur, S., Berger, T., Butz, E., Caspart, R., Chwalek, T., Boer, De, Dierlamm, W., Morabit, El, Faltermann, K., Giffels, N., Gottmann, M., Hartmann, A., Heidecker, F., Husemann, C., Iqbal, U., Kudella, M. A., Maier, S., Mitra, S., Mozer, S., Muller, M. U., Muller, D., Musich, Th, Nurnberg, M., Rabbertz, G., Savoiu, K., Schafer, D., Schnepf, D., Schroder, M., Shvetsov, M., Simonis, I, Ulrich, H. J., Wassmer, R., Weber, M., Wohrmann, M., Wolf, C., Wozniewski, R., Anagnostou, S., Asenov, G., Daskalakis, P., Geralis, G., Kyriakis, T., Loukas, A., Paspalaki, D., Stakia, G., Diamantopoulou, A., Karathanasis, M., Kontaxakis, G., Manousakis-katsikakis, P., Panagiotou, A., Papavergou, A., Saoulidou, I, Theofilatos, N., Vellidis, K., Vourliotis, K., Bakas, E., Kousouris, G., Papakrivopoulos, K., Tsipolitis, I, Zacharopoulou, G., Evangelou, A., Foudas, I, Gianneios, C., Katsoulis, P., Kokkas, P., Mallios, P., Manitara, S., Manthos, K., Papadopoulos, N., Strologas, I, Triantis, J., Tsitsonis, F. A., Bartok, D., Chudasama, M., Csanad, R., Major, M., P. M., Al, K., Mehta, A., Pasztor, G., Suranyi, O., Veres, I, Bencze, G., Hajdu, G., Horvath, C., Sikler, D., Veszpremi, F., Vesztergombi, V., Beni, G., Czellar, N., Karancsi, S., Molnar, J., Szillasi, J., Raics, Z., Teyssier, P., Trocsanyi, D., Ujvari, Z. L., Csorgo, B., Metzger, T., Nemes, W. J., Novak, F., Choudhury, T., Komaragiri, S., Tiwari, J. R., Bahinipati, P. C., Kar, S., Kole, C., Mal, G., Bindhu, P., Muraleedharan Nair, V. K., Nayak, A., Sahoo, D. K., Swain, S. K., Bansal, S., Beri, S. B., Bhatnagar, V, Chauhan, S., Dhingra, N., Gupta, R., Kaur, A., Kaur, M., Kaur, S., Kumari, P., Lohan, M., Meena, M., Eep, S, Sharma, K., Singh, S., Virdi, J. B., Walia, A. K., Bhardwaj, G., Choudhary, A., Garg, B. C., Gola, R. B., Keshri, M., Kumar, S., Ashok, Naimuddin, Priyanka, M., Ranjan, P., Shah, K., Aashaq, Sharma, Bhardwaj, R., Bharti, R., Bhattacharya, M., Bhattacharya, R., Bhaw, S., Eep, U., Bhowmik, D., Dutta, S., Ghosh, S., Gomber, B., Maity, M., Mondal, K., N, An, Purohit, S., Rout, A., Saha, P. K., Sarkar, G., Sharan, S., Singh, M., Thakur, B., Behera, S., Behera, P. K., Kalbhor, S. C., Muhammad, P., Pujahari, A., Sharma, P. R., Sikdar, A., Dutta, A. K., Jha, D., Mishra, V, Netrakanti, D. K., Pant, P. K., Shukla, L. M., Aziz, P., Bhat, T., Dugad, M. A., Mohanty, S., Sur, G. B., Verma, N., Ravindra, Kumar, Banerjee, S., Bhattacharya, S., Chatterjee, S., Das, P., Guchait, M., Karmakar, S., Majumder, G., Mazumdar, K., Sahoo, N., Sawant, S., Dube, S., Kansal, B., Kapoor, A., Kothekar, K., P, Ey, Rane, S., Rastogi, A., Sharma, A., Chenarani, S., Etesami, S., Khakzad, S. M., Najafabadi, M., Mohammadi, M., Naseri, M., Hosseinabadi, Rezaei, F., Felcini, M., Grunewald, M., Abbrescia, M., Aly, R., Calabria, C., Colaleo, A., Creanza, D., Cristella, L., Filippis, De, Palma, De, Florio, Di, Elmetenawee, A., Fiore, W., Gelmi, L., Iaselli, A., Ince, G., Lezki, M., Maggi, S., Maggi, G., Merlin, M., Miniello, J. A., My, G., Nuzzo, S., Pompili, S., Pugliese, A., Radogna, G., Ranieri, R., Selvaggi, A., Silvestris, G., Simone, L., Venditti, F. M., Verwilligen, R., Abbiendi, P., Battilana, G., Bonacorsi, C., Borgonovi, D., Braibant-Giacomelli, L., Campanini, S., Capiluppi, R., Castro, P., Cavallo, A., Codispoti, F. R., Cuffiani, G., Dallavalle, M., Fabbri, G. M., Fanfani, F., Fontanesi, A., Giacomelli, E., Giommi, P., Gr, L., I, C., Guiducci, L., Iemmi, F., Meo, Lo, Marcellini, S., Masetti, S., Navarria, G., Perrotta, F. L., Primavera, A., Rossi, F., Rovelli, A. M., Siroli, T., Tosi, G. P., Albergo, N., Costa, S., Mattia, Di, Potenza, A., Tricomi, R., Tuve, A., Barbagli, C., Cassese, G., Ceccarelli, A., Ciulli, R., Civinini, V, D'Aless, C., Ro, R., Fiori, F., Focardi, E., Latino, G., Lenzi, P., Meschini, M., Paoletti, S., Sguazzoni, G., Viliani, L., Benussi, L., Bianco, S., Piccolo, D., Bozzo, M., Ferro, F., Mulargia, R., Robutti, E., Tosi, S., Benaglia, A., Beschi, A., Brivio, F., Ciriolo, V, Dinardo, M. E., Dini, P., Gennai, S., Ghezzi, A., Govoni, P., Guzzi, L., Malberti, M., Malvezzi, S., Menasce, D., Monti, F., Moroni, L., Paganoni, M., Pedrini, D., Ragazzi, S., Fatis, De, Tabarelli, T., Valsecchi, D., Zuolo, D., Buontempo, S., Cavallo, N., Iorio, De, Crescenzo, Di, Fabozzi, A., Fienga, F., Galati, F., Iorio, G., Layer, A. O. M., Lista, L., Meola, L., Paolucci, S., Rossi, P., Sciacca, B., Voevodina, C., Azzi, E., Bacchetta, P., Bisello, N., Boletti, D., Bragagnolo, A., Carlin, A., Checchia, R., Manzano, P., De Castro, P., Dorigo, T., Dosselli, U., Gasparini, F., Gasparini, U., Gozzelino, A., Hoh, S. Y., Margoni, M., Meneguzzo, A. T., Pazzini, J., Presilla, M., Ronchese, P., Rossin, R., Simonetto, F., Tiko, A., Tosi, M., Zanetti, M., Zotto, P., Zucchetta, A., Zumerle, G., Braghieri, A., Fiorina, D., Montagna, P., Ratti, S. P., Re, V, Ressegotti, M., Riccardi, C., Salvini, P., Vai, I, Vitulo, P., Biasini, M., Bilei, G. M., Ciangottini, D., Fano, L., Lariccia, P., Leonardi, R., Manoni, E., Mantovani, G., Mariani, V, Menichelli, M., Rossi, A., Santocchia, A., Spiga, D., Rosov, K., Azzurri, P., Bagliesi, G., Bertacchi, V, Bianchini, L., Boccali, T., Castaldi, R., Ciocci, M. A., Dell'Orso, R., Donato, S., Giannini, L., Giassi, A., Grippo, M. T., Ligabue, F., Manca, E., Orli, M, Messineo, G., Palla, A., Rizzi, F., Rol, A., I, G., Chowdhury, Roy, S., Scribano, A., Spagnolo, P., Tenchini, R., Tonelli, G., Turini, N., Venturi, A., Verdini, P. G., Cavallari, F., Cipriani, M., Del, Re, Marco, Di, Diemoz, E., Longo, M., Meridiani, E., Organtini, P., G. P., Olfi, F., Paramatti, R., Quaranta, C., Rahatlou, S., Rovelli, C., Santanastasio, F., Soffi, L., Tramontano, R., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Bartosik, N., Bellan, R., Bellora, A., Biino, C., Cappati, A., Cartiglia, N., Cometti, S., Costa, M., Covarelli, R., Demaria, N., Fern, Ez, Gonzalez, J. R., Kiani, B., Legger, F., Mariotti, C., Maselli, S., Migliore, E., Monaco, V, Monteil, E., Monteno, M., Obertino, M. M., Ortona, G., Pacher, L., Pastrone, N., Pelliccioni, M., Angioni, Pinna, G. L., Romero, A., Ruspa, M., Salvatico, R., Sola, V, Solano, A., Soldi, D., Staiano, A., Trocino, D., Belforte, S., Elise, C, Casarsa, V, Cossutti, M., Rold, Da, Della, Ricca, Vazzoler, G., Zanetti, F., Kim, A., Kim, B., Kim, D. H., Lee, G. N., Lee, J., Moon, S. W., C. S., Oh, Pak, Y. D., I, S., Sekmen, S., Son, D. C., Yang, Y. C., Kim, H., Moon, D. H., Francois, B., Kim, T. J., Park, J., Cho, S., Choi, S., Go, Y., Ha, S., Hong, B., Lee, K., Lee, K. S., Lim, J., Park, S. K., Roh, Y., Yoo, J., Goh, J., Kim, H. S., Almond, J., Bhyun, J. H., Choi, J., Jeon, S., Kim, J., Kim, J. S., Lee, H., Lee, S., Nam, K., Oh, M., S. B., Oh, Radburn-Smith, B. C., Yang, U. K., Yoo, H. D., Yoon, I, Jeon, D., Kim, J. H., Lee, J. S. H., Park, I. C., Watson, I. J., Choi, Y., Hwang, C., Jeong, Y., Lee, Y., Yu, I, Veckalns, V., Dudenas, V, Juodagalvis, A., Rinkevicius, A., Tamulaitis, G., Vaitkus, J., Idris, Mohamad, F., Abdullah, Wan, W. A. T., Yusli, M. N., Zolkapli, Z., Benitez, J. F., Hern, Ez, Castaneda, A., Quijada, Murillo, J. A., Palomo, Valencia, L., Castilla-Valdez, H., De La Cruz-Burelo, Heredia-De La Cruz, Lopez-Fern, I, Ez, R., Sanchez-Hern, Ez, Moreno, A., Carrillo, S., Oropeza, Barrera, Ramirez-Garcia, C., Vazquez, Valencia, Eysermans, F., Pedraza, J., I, Salazar, Ibarguen, H. A., Uribe, Estrada, Pineda, C., Morelos, A., Mijuskovic, J., Raicevic, N., Krofcheck, D., Bheesette, S., Butler, P. H., Lujan, P., Ahmad, A., Ahmad, M., Awan, M. I. M., Hassan, Q., Hoorani, H. R., Khan, W. A., Shah, M. A., Shoaib, M., Waqas, M., Avati, V, Grzanka, L., Malawski, M., Bialkowska, H., Bluj, M., Boimska, B., Gorski, M., Kazana, M., Szleper, M., Zalewski, P., Bunkowski, K., Byszuk, A., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski, J., Olszewski, M., Walczak, M., Araujo, M., Bargassa, P., Bastos, D., Francesco, Di, Faccioli, A., Galinhas, P., Gallinaro, B., Hollar, M., Leonardo, J., Niknejad, N., Seixas, T., Shchelina, J., Strong, K., Toldaiev, G., Varela, O., Afanasiev, J., Bunin, S., Ershov, P., Golutvin, Y., Gorbunov, I, Kamenev, I, Karjavine, A., Korenkov, V, Lanev, V, Malakhov, A., Matveev, A., Mitsyn, V, Moisenz, V. V., Palichik, P., Perelygin, V, Shmatov, V, Skatchkov, S., Yuldashev, N., Zarubin, B. S., Zhiltsov, A., Chtchipounov, V, Golovtcov, L., Ivanov, V, Kim, Y., Kuznetsova, V, Levchenko, E., Murzin, P., Oreshkin, V, Smirnov, V, Sosnov, I, Sulimov, D., Uvarov, V, Vorobyev, L., Reev, A., Dermenev, Yu, Gninenko, A., Golubev, S., Karneyeu, N., Kirsanov, A., Krasnikov, M., Pashenkov, N., Tlisov, A., Toropin, D., Epshteyn, A., Gavrilov, V, Lychkovskaya, V, Nikitenko, N., Popov, A., Pozdnyakov, V, Safronov, I, Spiridonov, G., Stepennov, A., Toms, A., Vlasov, M., Zhokin, E., Aushev, A., Bychkova, T., Chistov, O., Danilov, R., Polikarpov, M., Tarkovskii, S., Reev, E., Azarkin, V, Dremin, M., Kirakosyan, I, Terkulov, M., Belyaev, A., Boos, A., Demiyanov, E., Ershov, A., Gribushin, A., Kodolova, A., Korotkikh, O., Lokhtin, V, Obraztsov, I, Petrushanko, S., Savrin, S., Snigirev, V, Vardanyan, A., Barnyakov, I, Blinov, A., Dimova, V, Kardapoltsev, T., Skovpen, L., Azhgirey, Y., Bayshev, I, Bitioukov, I, Kachanov, S., Konstantinov, V, D. M., Rik, P., Petrov, V, Ryutin, R., Slabospitskii, S., Sobol, A., Troshin, S., Tyurin, N., Uzunian, A., Volkov, A., Babaev, A., Iuzhakov, A., Okhotnikov, V, Borchsh, V, Ivanchenko, V, Tcherniaev, E., Adzic, P., Cirkovic, P., Dordevic, M., Milenovic, P., Milosevic, J., Stojanovic, M., Aguilar-Benitez, M., Alcaraz, Maestre, Alvarez, Fern, Ez, A., Bachiller, I, Barrio, Luna, Bedoya, M., Cristina, F., Brochero, Cifuentes, J. A., Carrillo, Montoya, Cepeda, C. A., Cerrada, M., Colino, M., De la Cruz, Delgado, Peris, Fern, A., Ramos, Ez, Flix, J. P., Fouz, J., M. C., Gonzalez, Lopez, Goy, Lopez, Hern, S., J. M., Ez, Josa, I, Moran, M., Navarro, Tobar, Perez-Calero, Yzquierdo, Puerta, Pelayo, Redondo, J., Romero, I, Sanchez, Navas, Soares, S., Triossi, M. S., Willmott, A., Albajar, C., Troconiz, De, Reyes-Almanza, J. F., Alvarez, Gonzalez, Cuevas, B., Erice, J., Fern, C., Menendez, Ez, Folgueras, J., Gonzalez, Caballero, Palencia, Cortezon, Ramon, Alvarez, Rodriguez, Bouza, V, Sanchez, Cruz, Cabrillo, S., Calderon, I. J., Chazin, Quero, Duarte, Campderros, Fern, J., Ez, M., Manteca, Ez, P. J., Garcia, Alonso, Gomez, A., Martinez, Rivero, Martinez Ruiz del Arbol, Matorras, P., Piedra, Gomez, Prieels, J., Ricci-Tam, C., Rodrigo, F., Ruiz-Jimeno, T., Russo, A., Scodellaro, L., Vila, L., Vizan, Garcia, Sonnadara, J. M., Dharmaratna, D. U. J., Wickramage, W. G. D., Aarrestad, N., Abbaneo, T. K., Akgun, D., Auffray, B., Auzinger, E., Baechler, G., Baillon, J., Ball, P., Barney, A. H., Bendavid, D., Bianco, J., Bocci, M., Bortignon, A., Bossini, P., Brondolin, E., Camporesi, E., Caratelli, T., Cerminara, A., Chapon, G., Cucciati, E., D'Enterria, G., Dabrowski, D., Daci, A., Daponte, N., David, V, Davignon, A., Roeck, De, Deile, A., Maria, Di, Dobson, R., Dunser, M., Dupont, M., Elliott-Peisert, N., Emriskova, A., Fallavollita, N., Fasanella, F., Fiorendi, D., Franzoni, S., Fulcher, G., Funk, J., Giani, W., Gigi, S., Gill, D., Glege, K., Gouskos, F., Gruchala, L., Guilbaud, M., Gulhan, M., Hegeman, D., Heidegger, J., Iiyama, C., Innocente, Y., James, V, Janot, T., Karacheban, P., Kaspar, O., Kieseler, J., Krammer, J., Kratochwil, M., Lange, N., Lecoq, C., Long, P., Lourenco, K., Malgeri, C., Mannelli, L., Massironi, M., Meijers, A., Mersi, F., Meschi, S., Moortgat, E., Mulders, F., Ngadiuba, M., Niedziela, J., Nourbakhsh, J., Orfanelli, S., Orsini, S., Pantaleo, L., Pape, F., Perez, L., Peruzzi, E., Petrilli, M., Petrucciani, A., Pfeiffer, G., Pierini, A., Pitters, M., Rabady, F. M., Racz, D., Rovere, M., Sakulin, M., Salfeld-Nebgen, H., Scarfi, J., Schafer, S., Schwick, C., Selvaggi, C., Sharma, M., Silva, A., Snoeys, P., Sphicas, W., Steggemann, P., Summers, J., Tavolaro, S., Treille, V. R., Tsirou, D., Van, Onsem, Vartak, G. P., Verzetti, A., Wozniak, M., Zeuner, K. A., Caminada, W. D., Deiters, L., Erdmann, K., Horisberger, W., Ingram, R., Kaestli, Q., Kotlinski, H. C., Langenegger, D., Rohe, U., Backhaus, T., Berger, M., Cal, P., Ri, A., Chernyavskaya, N., Dissertori, G., Dittmar, M., Donega, M., Dorfer, C., Espinosa, Gomez, T. A., Grab, C., Hits, D., Lustermann, W., Manzoni, R. A., Meinhard, M. T., Micheli, F., Musella, P., Nessi-Tedaldi, F., Pauss, F., Perovic, V, Perrin, G., Perrozzi, L., Pigazzini, S., Ratti, M. G., Reichmann, M., Reissel, C., Reitenspiess, T., Ristic, B., Ruini, D., Becerra, Sanz, D. A., Schonenberger, M., Shchutska, L., Olsson, Vesterbacka, M. L., Wallny, R., Zhu, D. H., Amsler, C., Botta, C., Brzhechko, D., Canelli, M. F., Cosa, De, Del, Burgo, Kilminster, R., Leontsinis, B., Mikuni, S., Neutelings, V. M., Rauco, I, Robmann, G., Schweiger, P., Takahashi, K., Wertz, Y., Kuo, S., Lin, C. M., Roy, W., Sarkar, A., Yu, T., Chang, S. S., Chao, P., Chen, K. F., Hou, P. H., W-S, Li, Y. Y., Lu, R-S, Paganis, Psallidas, E., Steen, A., Asavapibhop, A., Asawatangtrakuldee, B., Srimanobhas, C., Suwonj, N., Ee, N., Bat, A., Boran, F., Celik, A., Damarseckin, S., Demiroglu, Z. S., Dolek, F., Dozen, C., Dumanoglu, I, Gokbulut, G., Guler, Emine, Gurpinar, Guler, Y., Hos, I, Isik, C., Kangal, E. E., Kara, O., Topaksu, Kayis, A., Kiminsu, U., Onengut, G., Ozdemir, K., Simsek, A. E., Tok, U. G., Turkcapar, S., Zorbakir, I. S., Zorbilmez, C., Isildak, B., Karapinar, G., Yalvac, M., Atakisi, I. O., Gulmez, E., Kaya, M., Kaya, O., Tekten, S., Yetkin, E. A., Cakir, A., Cankocak, K., Komurcu, Y., Sen, S., Cerci, S., Kaynak, B., Ozkorucuklu, S., Cerci, Sunar, D., Grynyov, B., Levchuk, L., Bhal, E., Bologna, S., Brooke, J. J., Burns, D., Clement, E., Cussans, D., Flacher, H., Goldstein, J., Heath, G. P., Heath, H. F., Kreczko, L., Krikler, B., Paramesvaran, S., Sakuma, T., Nasr-Storey, El, Seif, S., Smith, V. J., Taylor, J., Titterton, A., Bell, K. W., Brew, C., Brown, R. M., Cockerill, D. J. A., Coughlan, J. A., Harder, K., Harper, S., Linacre, J., Manolopoulos, K., Newbold, D. M., Olaiya, E., Petyt, D., Reis, T., Schuh, T., Shepherd-Themistocleous, C. H., Thea, A., Tomalin, I. R., Williams, T., Bainbridge, R., Bloch, P., Bonomally, S., Borg, J., Breeze, S., Buchmuller, O., Bundock, A., Chahal, Gurpreet, Singh, Colling, D., Dauncey, P., Davies, G., Della, Negra, Everaerts, M., Hall, P., Iles, G., Komm, G., Langford, M., Lyons, J., Magnan, L., A-M, Malik, Martelli, S., Milosevic, A., Morton, V, Nash, A., Palladino, J., Pesaresi, V, Raymond, M., Richards, D. M., Rose, A., Scott, A., Seez, E., Shtipliyski, C., Stoye, A., Strebler, M., Tapper, T., Uchida, A., Virdee, K., Wardle, T., Webb, N., Winterbottom, S. N., Zecchinelli, D., Zenz, A. G., Cole, S. C., Hobson, J. E., Khan, P. R., Kyberd, A., Mackay, P., Reid, C. K., Teodorescu, I. D., Zahid, L., Brinkerhoff, S., Call, A., Caraway, K., Dittmann, B., Hatakeyama, J., Madrid, K., Mcmaster, C., Pastika, B., Smith, N., Bartek, C., Dominguez, R., Uniyal, A., Hern, R., Vargas, A. M., Buccilli, A., Cooper, I, Gleyzer, S., V, S., Henderson, C., Rumerio, P., West, C., Albert, A., Arcaro, D., Demiragli, Z., Gastler, D., Richardson, C., Rohlf, J., Sperka, D., Spitzbart, D., Suarez, I, Sulak, L., Zou, D., Benelli, G., Burkle, B., Coubez, X., Cutts, D., Duh, Y. T., Hadley, M., Heintz, U., Hogan, J. M., Kwok, K. H. M., Laird, E., Sberg, L, Lau, G., Lee, K. T., Narain, J., Sagir, M., Syarif, S., Usai, R., Wong, E., W. Y., Yu, Zhang, D., W. B., Brainerd, R., Breedon, C., Sanchez, R., Calderon De La Barca, M., Chertok, M., Conway, J., Conway, R., Cox, P. T., Erbacher, R., Flores, C., Funk, G., Jensen, F., Ko, W., Kukral, O., L, Er, Mulhearn, R., Pellett, M., Pilot, D., Shi, J., Taylor, M., Tos, D., Tripathi, K., Wang, M., Zhang, Z., Bachtis, F., Bravo, M., Cousins, C., Dasgupta, R., Florent, A., Hauser, A., Ignatenko, J., Mccoll, M., Nash, N., Regnard, W. A., Saltzberg, S., Schnaible, D., Stone, C., Valuev, B., Burt, V., Chen, K., Clare, Y., Gary, R., Shirazi, J. W., Ghiasi, S. M. A., Hanson, G., Karapostoli, G., Long, O. R., Manganelli, N., Negrete, Olmedo, M., Paneva, I, Si, M., Wimpenny, W., Yates, S., Zhang, B. R., Branson, Y., Chang, J. G., Cittolin, P., Cooperstein, S., Deelen, S., Derdzinski, N., Duarte, M., Gerosa, J., Gilbert, R., Hashemi, D., Klein, B., Krutelyov, D., Letts, V, Masciovecchio, J., May, M., Padhi, S., Pieri, S., Tadel, V, Wurthwein, M., Yagil, F., Della, Porta, Zevi, G., Amin, N., Ari, Bh, Campagnari, R., Citron, C., Dutta, M., Inc, V, Ela, J., Marsh, B., Mei, H., Ovcharova, A., Qu, H., Richman, J., Sarica, U., Stuart, D., Wang, S., Erson, D., Bornheim, A., Cerri, O., Dutta, I, Lawhorn, J. M., Lu, N., Mao, J., Newman, H. B., Nguyen, T. Q., Pata, J., Spiropulu, M., Vlimant, J. R., Xie, S., Zhu, R. Y., Alison, J., Rews, M. B., Ferguson, T., Mudholkar, T., Paulini, M., Sun, M., Vorobiev, I, Weinberg, M., Cumalat, J. P., Ford, W. T., Macdonald, E., Mulholl, T., Patel, R., Perloff, A., Stenson, K., Ulmer, K. A., Wagner, S. R., Alex, Er, Cheng, J., Chu, Y., Datta, J., Frankenthal, A., Mcdermott, A., Patterson, K., Quach, J. R., Ryd, D., Tan, A., Tao, S. M., Thom, Z., Wittich, J., Zientek, P., Abdullin, M., Albrow, S., Alyari, M., Apollinari, M., Apresyan, G., Apyan, A., Banerjee, A., Bauerdick, S., Beretvas, L. A. T., Berry, A., Berryhill, D., Bhat, J., Burkett, P. C., Butler, K., Canepa, J. N., Cerati, A., Cheung, G. B., Chlebana, H. W. K., Cremonesi, F., Elvira, M., Freeman, V. D., Gecse, J., Gottschalk, Z., Gray, E., Green, L., Grunendahl, D., Gutsche, S., Hanlon, O., Harris, J., Hasegawa, R. M., Heller, S., Hirschauer, R., Jayatilaka, J., Jindariani, B., Johnson, S., Joshi, M., Klijnsma, U., Klima, T., Kortelainen, B., Kreis, M. J., Lammel, B., Lewis, S., Lincoln, J., Lipton, D., Liu, R., Liu, M., Lykken, T., Maeshima, J., Marraffino, K., Mason, J. M., Mcbride, D., Merkel, P., Mrenna, P., Nahn, S., O'Dell, S., Papadimitriou, V, Pedro, V, Pena, K., Ravera, C., Hall, F., Reinsvold, A., Ristori, L., Schneider, B., Sexton-Kennedy, E., Soha, A., Spalding, W. J., Spiegel, L., Stoynev, S., Strait, J., Taylor, L., Tkaczyk, S., Tran, V, Uplegger, N., Va, L., Ering, E. W., Vidal, R., Weber, H. A., Woodard, A., Acosta, D., Avery, P., Bourilkov, D., Cadamuro, L., Cherepanov, V, Errico, F., Field, R. D., Guerrero, D., Joshi, B. M., Kim, M., Konigsberg, J., Korytov, A., K. H., Lo, Matchev, K., Menendez, N., Mitselmakher, G., Rosenzweig, D., Shi, K., Wang, J., Zuo, X., Joshi, Y. R., Adams, T., Askew, A., Hagopian, S., Hagopian, V, Johnson, K. F., Khurana, R., Kolberg, T., Martinez, G., Perry, T., Prosper, H., Schiber, C., Yohay, R., Zhang, J., Baarm, M. M., Hohlmann, M., Noonan, D., Rahmani, M., Saunders, M., Yumiceva, F., Adams, M. R., Apanasevich, L., Betts, R. R., Cavanaugh, R., Chen, X., Dittmer, S., Evdokimov, O., Gerber, C. E., Hangal, D. A., Hofman, D. J., Kumar, V, Mills, C., Oh, G., Roy, T., Tonjes, M. B., Varelas, N., Viinikainen, J., Wang, H., Wang, X., Wu, Z., Alhusseini, M., Bilki, B., Dilsiz, K., Durgut, S., Rajula, G, Haytmyradov, R. P., Khristenko, M., Koseyan, V, Merlo, O. K., J-P, Mestvirishvili, Moeller, A., Nachtman, A., Ogul, J., Onel, H., Ozok, Y., Penzo, F., Snyder, A., Tiras, C., Wetzel, E., Yi, J., Blumenfeld, K., Cocoros, B., Eminizer, A., Gritsan, N., V, A., Hung, W. T., Kyriacou, S., Maksimovic, P., Mantilla, C., Roskes, J., Swartz, M., Vami, T. A., Barrera, Baldenegro, C., Baringer, P., Bean, A., Boren, S., Bylinkin, A., Isidori, T., Khalil, S., King, J., Krintiras, G., Kropivnitskaya, A., Lindsey, C., Majumder, D., Mcbrayer, W., Minafra, N., Murray, M., Rogan, C., Royon, C., Ers, S, Schmitz, S., Takaki, E., Tapia, J. D., Wang, Q., Williams, J., Wilson, G., Duric, S., Kaadze, K., Kim, D., Maravin, Y., Mendis, D. R., Mitchell, T., Modak, A., Mohammadi, A., Rebassoo, F., Wright, D., Baden, A., Baron, O., Belloni, A., Eno, S. C., Feng, Y., Hadley, N. J., Jabeen, S., Jeng, G. Y., Kellogg, R. G., Mignerey, A. C., Nabili, S., Seidel, M., Skuja, A., Tonwar, S. C., Wang, L., Wong, K., Abercrombie, D., Allen, B., Bi, R., Br, T, Busza, S., Cali, W., D'Alfonso, I. A., Ceballos, M., Gomez, G., Goncharov, M., Harris, P., Hsu, D., Klute, M., Kovalskyi, D., Lee, Y-J, Luckey, P. D., Maier, B., Marini, A. C., Mcginn, C., Mironov, C., Narayanan, S., Niu, X., Paus, C., Rankin, D., Rol, Rol, C., Shi, G., Stephans, Z., Sumorok, G. S. F., Tatar, K., Velicanu, K., Wyslouch, T. W., Chatterjee, B., Evans, R. M., Guts, A., Hansen, S., Hiltbr, P., Jain, J., Kubota, Sh, Lesko, Y., Mans, Z., Revering, J., Rusack, M., Saradhy, R., Schroeder, R., Strobbe, N., Wadud, N., Acosta, M. A., Oliveros, J. G., Bloom, S., Chauhan, K., Claes, S., Fangmeier, D. R., Finco, C., Golf, L., Kamalieddin, F., Kravchenko, R., Siado, I, Snow, J. E., Stieger, G. R., Tabb, B., Agarwal, W., Harrington, G., Iashvili, C., Kharchilava, I., Mclean, A., Nguyen, C., Parker, D., Pekkanen, A., Rappoccio, J., Roozbahani, S., Alverson, B., Barberis, G., Freer, E., Haddad, C., Hortiangtham, Y., Madigan, A., Marzocchi, G., Morse, B., Nguyen, D. M., Orimoto, V, Skinnari, T., Tishelman-Charny, L., Wamorkar, A., Wang, T., Wisecarver, B., Wood, A., Bhattacharya, D., Bueghly, S., Fedi, J., Gilbert, G., Gunter, A., Hahn, T., Odell, K. A., Schmitt, N., Sung, M. H., Velasco, K., Bucci, M., Dev, R., Goldouzian, N., Hildreth, R., Anampa, M., Hurtado, K., Jessop, C., Karmgard, D. J., Lannon, K., Li, W., Loukas, N., Marinelli, N., Mcalister, I, Meng, F., Musienko, Y., Ruchti, R., Siddireddy, P., Smith, G., Taroni, S., Wayne, M., Wightman, A., Wolf, M., Alimena, J., Bylsma, B., Cardwell, B., Durkin, L. S., Francis, B., Hill, C., Ji, W., Lefeld, A., Ling, T. Y., Winer, B. L., Dezoort, G., Elmer, P., Hardenbrook, J., Haubrich, N., Higginbotham, S., Kalogeropoulos, A., Kwan, S., Lange, D., Lucchini, M. T., Luo, J., Marlow, D., Mei, K., Ojalvo, I, Olsen, J., Palmer, C., Piroue, P., Stickl, D., Tully, C., Malik, S., Norberg, S., Barker, A., Barnes, V. E., Chawla, R., Das, S., Gutay, L., Jones, M., Jung, A. W., Mahakud, B., Miller, D. H., Negro, G., Neumeister, N., Peng, C. C., Piperov, S., Qiu, H., Schulte, J. F., Trevisani, N., Wang, F., Xiao, R., Xie, W., Cheng, T., Dolen, J., Parashar, N., Baty, A., Behrens, U., Dildick, S., Ecklund, K. M., Freed, S., Geurts, F. J. M., Kilpatrick, M., Kumar, Arun, Padley, B. P., Redjimi, R., Roberts, J., Rorie, J., Shi, W., Leiton, Stahl, A. G., Tu, Z., Zhang, A., Bodek, A., Barbaro, De, Demina, P., Dulemba, R., Fallon, J. L., Ferbel, C., Galanti, T., Garcia-Bellido, M., Hindrichs, A., Khukhunaishvili, O., Ranken, A., Taus, E., Chiarito, R., Chou, B., J. P. G., Rakota, A., Gershtein, Y., Halkiadakis, E., Hart, A., Heindl, M., Hughes, E., Kaplan, S., Laflotte, I, Lath, A., Montalvo, R., Nash, K., Osherson, M., Salur, S., Schnetzer, S., Somalwar, S., Stone, R., Thomas, S., Acharya, H., Delannoy, A. G., Spanier, S., Bouhali, O., Dalchenko, M., Mattia, De, Delgado, M., Eusebi, A., Gilmore, R., Huang, J., Kamon, T., Kim, T., Luo, H., Malhotra, S., Marley, S., Mueller, D., Overton, R., Pernie, D., Rathjens, L., Safonov, D., Akchurin, A., Damgov, N., Guio, De, Hegde, F., Kunori, V, Lamichhane, S., Mengke, S. W., Muthumuni, T., Peltola, S., Undleeb, T., Volobouev, S., Wang, I, Whitbeck, Z., Greene, A., Gurrola, S., Janjam, A., Johns, R., Maguire, W., Melo, C., Ni, A., Padeken, H., Romeo, K., Sheldon, F., Tuo, P., Velkovska, S., Verweij, J., Arenton, M., Barria, M. W., Cox, P., Cummings, B., Hakala, G., Hirosky, J., Joyce, R., Ledovskoy, M., Neu, A., Tannenwald, C., Wang, B., Wolfe, Y., Xia, E., Harr, F., Karchin, R., Poudyal, P. E., Sturdy, N., Thapa, J., Black, P., Bose, K., Buchanan, T., Caillol, J., Carlsmith, C., Dasu, D., Bruyn, De, Dodd, I, Galloni, L., He, C., Herndon, H., Herve, M., Hussain, A., Lanaro, U., Loeliger, A., Loveless, A., Sreekala, R., Madhusudanan, J., Mallampalli, A., Pinna, D., Ruggles, T., Savin, A., Sharma, V, Smith, W. H., Teague, D., Trembath-reichert, S., and Cms, Collaboration

Subjects
MODEL, Physics and Astronomy, High Energy Physics::Experiment, QUARK-GLUON PLASMA, Nuclear Experiment
Abstract

The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of root s(NN) = 5.02 TeV per nucleon pair, using the decay chain X(3872) -> J/psi pi(+)pi(-) -> mu(+) mu(-) pi(+)pi(-). The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb(-1). The measurement is performed in the rapidity and transverse momentum ranges vertical bar y vertical bar < 1.6 and 15 < p(T) < 50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to psi 2S yield ratio is found to be rho(Pb-Pb) = 1.08 +/- 0.49(stat) +/- 0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.

Published
2022

21. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce.

Author

Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., Michaels K., Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., and Michaels K.

Abstract

To date, 18 living recommendations for the clinical care of pregnant and postpartum women with COVID-19 have been issued by the National COVID-19 Clinical Evidence Taskforce. This includes recommendations on mode of birth, delayed umbilical cord clamping, skin-to-skin contact, breastfeeding, rooming-in, antenatal corticosteroids, angiotensin-converting enzyme inhibitors, disease-modifying treatments (including dexamethasone, remdesivir and hydroxychloroquine), venous thromboembolism prophylaxis and advanced respiratory support interventions (prone positioning and extracorporeal membrane oxygenation). Through continuous evidence surveillance, these living recommendations are updated in near real-time to ensure clinicians in Australia have reliable, evidence-based guidelines for clinical decision-making. Please visit https://covid19evidence.net.au/ for the latest recommendation updates.Copyright © 2020 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists

Published
2021

22. The trans-ancestral genomic architecture of glycemic traits

Author

Chen, J. (Ji), Spracklen, C. N. (Cassandra N.), Marenne, G. (Gaelle), Varshney, A. (Arushi), Corbin, L. J. (Laura J.), Luan, J. (Jian'an), Willems, S. M. (Sara M.), Wu, Y. (Ying), Zhang, X. (Xiaoshuai), Horikoshi, M. (Momoko), Boutin, T. S. (Thibaud S.), Magi, R. (Reedik), Waage, J. (Johannes), Li-Gao, R. (Ruifang), Chan, K. H. (Kei Hang Katie), Yao, J. (Jie), Anasanti, M. D. (Mila D.), Chu, A. Y. (Audrey Y.), Claringbould, A. (Annique), Heikkinen, J. (Jani), Hong, J. (Jaeyoung), Hottenga, J.-J. (Jouke-Jan), Huo, S. (Shaofeng), Kaakinen, M. A. (Marika A.), Louie, T. (Tin), Maerz, W. (Winfried), Moreno-Macias, H. (Hortensia), Ndungu, A. (Anne), Nelson, S. C. (Sarah C.), Nolte, I. M. (Ilja M.), North, K. E. (Kari E.), Raulerson, C. K. (Chelsea K.), Ray, D. (Debashree), Rohde, R. (Rebecca), Rybin, D. (Denis), Schurmann, C. (Claudia), Sim, X. (Xueling), Southam, L. (Lorraine), Stewart, I. D. (Isobel D.), Wang, C. A. (Carol A.), Wang, Y. (Yujie), Wu, P. (Peitao), Zhang, W. (Weihua), Ahluwalia, T. S. (Tarunveer S.), Appel, E. V. (Emil V. R.), Bielak, L. F. (Lawrence F.), Brody, J. A. (Jennifer A.), Burtt, N. P. (Noel P.), Cabrera, C. P. (Claudia P.), Cade, B. E. (Brian E.), Chai, J. F. (Jin Fang), Chai, X. (Xiaoran), Chang, L.-C. (Li-Ching), Chen, C.-H. (Chien-Hsiun), Chen, B. H. (Brian H.), Chitrala, K. N. (Kumaraswamy Naidu), Chiu, Y.-F. (Yen-Feng), de Haan, H. G. (Hugoline G.), Delgado, G. E. (Graciela E.), Demirkan, A. (Ayse), Duan, Q. (Qing), Engmann, J. (Jorgen), Fatumo, S. A. (Segun A.), Gayan, J. (Javier), Giulianini, F. (Franco), Gong, J. H. (Jung Ho), Gustafsson, S. (Stefan), Hai, Y. (Yang), Hartwig, F. P. (Fernando P.), He, J. (Jing), Heianza, Y. (Yoriko), Huang, T. (Tao), Huerta-Chagoya, A. (Alicia), Hwang, M. Y. (Mi Yeong), Jensen, R. A. (Richard A.), Kawaguchi, T. (Takahisa), Kentistou, K. A. (Katherine A.), Kim, Y. J. (Young Jin), Kleber, M. E. (Marcus E.), Kooner, I. K. (Ishminder K.), Lai, S. (Shuiqing), Lange, L. A. (Leslie A.), Langefeld, C. D. (Carl D.), Lauzon, M. (Marie), Li, M. (Man), Ligthart, S. (Symen), Liu, J. (Jun), Loh, M. (Marie), Long, J. (Jirong), Lyssenko, V. (Valeriya), Mangino, M. (Massimo), Marzi, C. (Carola), Montasser, M. E. (May E.), Nag, A. (Abhishek), Nakatochi, M. (Masahiro), Noce, D. (Damia), Noordam, R. (Raymond), Pistis, G. (Giorgio), Preuss, M. (Michael), Raffield, L. (Laura), Rasmussen-Torvik, L. J. (Laura J.), Rich, S. S. (Stephen S.), Robertson, N. R. (Neil R.), Rueedi, R. (Rico), Ryan, K. (Kathleen), Sanna, S. (Serena), Saxena, R. (Richa), Schraut, K. E. (Katharina E.), Sennblad, B. (Bengt), Setoh, K. (Kazuya), Smith, A. V. (Albert V.), Sparso, T. (Thomas), Strawbridge, R. J. (Rona J.), Takeuchi, F. (Fumihiko), Tan, J. (Jingyi), Trompet, S. (Stella), van den Akker, E. (Erik), van der Most, P. J. (Peter J.), Verweij, N. (Niek), Vogel, M. (Mandy), Wang, H. (Heming), Wang, C. (Chaolong), Wang, N. (Nan), Warren, H. R. (Helen R.), Wen, W. (Wanqing), Wilsgaard, T. (Tom), Wong, A. (Andrew), Wood, A. R. (Andrew R.), Xie, T. (Tian), Zafarmand, M. H. (Mohammad Hadi), Zhao, J.-H. (Jing-Hua), Zhao, W. (Wei), Amin, N. (Najaf), Arzumanyan, Z. (Zorayr), Astrup, A. (Arne), Bakker, S. J. (Stephan J. L.), Baldassarre, D. (Damiano), Beekman, M. (Marian), Bergman, R. N. (Richard N.), Bertoni, A. (Alain), Blueher, M. (Matthias), Bonnycastle, L. L. (Lori L.), Bornstein, S. R. (Stefan R.), Bowden, D. W. (Donald W.), Cai, Q. (Qiuyin), Campbell, A. (Archie), Campbell, H. (Harry), Chang, Y. C. (Yi Cheng), de Geus, E. J. (Eco J. C.), Dehghan, A. (Abbas), Du, S. (Shufa), Eiriksdottir, G. (Gudny), Farmaki, A. E. (Aliki Eleni), Franberg, M. (Mattias), Fuchsberger, C. (Christian), Gao, Y. (Yutang), Gjesing, A. P. (Anette P.), Goel, A. (Anuj), Han, S. (Sohee), Hartman, C. A. (Catharina A.), Herder, C. (Christian), Hicks, A. A. (Andrew A.), Hsieh, C.-H. (Chang-Hsun), Hsueh, W. A. (Willa A.), Ichihara, S. (Sahoko), Igase, M. (Michiya), Ikram, M. A. (M. Arfan), Johnson, W. C. (W. Craig), Jorgensen, M. E. (Marit E.), Joshi, P. K. (Peter K.), Kalyani, R. R. (Rita R.), Kandeel, F. R. (Fouad R.), Katsuya, T. (Tomohiro), Khor, C. C. (Chiea Chuen), Kiess, W. (Wieland), Kolcic, I. (Ivana), Kuulasmaa, T. (Teemu), Kuusisto, J. (Johanna), Lall, K. (Kristi), Lam, K. (Kelvin), Lawlor, D. A. (Deborah A.), Lee, N. R. (Nanette R.), Lemaitre, R. N. (Rozenn N.), Li, H. (Honglan), Lin, S.-Y. (Shih-Yi), Lindstrom, J. (Jaana), Linneberg, A. (Allan), Liu, J. (Jianjun), Lorenzo, C. (Carlos), Matsubara, T. (Tatsuaki), Matsuda, F. (Fumihiko), Mingrone, G. (Geltrude), Mooijaart, S. (Simon), Moon, S. (Sanghoon), Nabika, T. (Toru), Nadkarni, G. N. (Girish N.), Nadler, J. L. (Jerry L.), Nelis, M. (Mari), Neville, M. J. (Matt J.), Norris, J. M. (Jill M.), Ohyagi, Y. (Yasumasa), Peters, A. (Annette), Peyser, P. A. (Patricia A.), Polasek, O. (Ozren), Qi, Q. (Qibin), Raven, D. (Dennis), Reilly, D. F. (Dermot F.), Reiner, A. (Alex), Rivideneira, F. (Fernando), Roll, K. (Kathryn), Rudan, I. (Igor), Sabanayagam, C. (Charumathi), Sandow, K. (Kevin), Sattar, N. (Naveed), Schuermann, A. (Annette), Shi, J. (Jinxiu), Stringham, H. M. (Heather M.), Taylor, K. D. (Kent D.), Teslovich, T. M. (Tanya M.), Thuesen, B. (Betina), Timmers, P. R. (Paul R. H. J.), Tremoli, E. (Elena), Tsai, M. Y. (Michael Y.), Uitterlinden, A. (Andre), van Dam, R. M. (Rob M.), van Heemst, D. (Diana), van Hylckama Vlieg, A. (Astrid), van Vliet-Ostaptchouk, J. V. (Jana V.), Vangipurapu, J. (Jagadish), Vestergaard, H. (Henrik), Wang, T. (Tao), Willems van Dijk, K. (Ko), Zemunik, T. (Tatijana), Abecasis, G. R. (Goncalo R.), Adair, L. S. (Linda S.), Aguilar-Salinas, C. A. (Carlos Alberto), Alarcon-Riquelme, M. E. (Marta E.), An, P. (Ping), Aviles-Santa, L. (Larissa), Becker, D. M. (Diane M.), Beilin, L. J. (Lawrence J.), Bergmann, S. (Sven), Bisgaard, H. (Hans), Black, C. (Corri), Boehnke, M. (Michael), Boerwinkle, E. (Eric), Boehm, B. O. (Bernhard O.), Bonnelykke, K. (Klaus), Boomsma, D. I. (D. I.), Bottinger, E. P. (Erwin P.), Buchanan, T. A. (Thomas A.), Canouil, M. (Mickael), Caulfield, M. J. (Mark J.), Chambers, J. C. (John C.), Chasman, D. I. (Daniel I.), Chen, Y. I. (Yii-Der Ida), Cheng, C.-Y. (Ching-Yu), Collins, F. S. (Francis S.), Correa, A. (Adolfo), Cucca, F. (Francesco), de Silva, H. J. (H. Janaka), Dedoussis, G. (George), Elmstahl, S. (Solve), Evans, M. K. (Michele K.), Ferrannini, E. (Ele), Ferrucci, L. (Luigi), Florez, J. C. (Jose C.), Franks, P. W. (Paul W.), Frayling, T. M. (Timothy M.), Froguel, P. (Philippe), Gigante, B. (Bruna), Goodarzi, M. O. (Mark O.), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grarup, N. (Niels), Grimsgaard, S. (Sameline), Groop, L. (Leif), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Hamsten, A. (Anders), Hansen, T. (Torben), Hayward, C. (Caroline), Heckbert, S. R. (Susan R.), Horta, B. L. (Bernardo L.), Huang, W. (Wei), Ingelsson, E. (Erik), James, P. S. (Pankow S.), Järvelin, M.-R. (Marjo-Ritta), Jonas, J. B. (Jost B.), Jukema, J. W. (J. Wouter), Kaleebu, P. (Pontiano), Kaplan, R. (Robert), Kardia, S. L. (Sharon L. R.), Kato, N. (Norihiro), Keinanen-Kiukaanniemi, S. M. (Sirkka M.), Kim, B.-J. (Bong-Jo), Kivimaki, M. (Mika), Koistinen, H. A. (Heikki A.), Kooner, J. S. (Jaspal S.), Koerner, A. (Antje), Kovacs, P. (Peter), Kuh, D. (Diana), Kumari, M. (Meena), Kutalik, Z. (Zoltan), Laakso, M. (Markku), Lakka, T. A. (Timo A.), Launer, L. J. (Lenore J.), Leander, K. (Karin), Li, H. (Huaixing), Lin, X. (Xu), Lind, L. (Lars), Lindgren, C. (Cecilia), Liu, S. (Simin), Loos, R. J. (Ruth J. F.), Magnusson, P. K. (Patrik K. E.), Mahajan, A. (Anubha), Metspalu, A. (Andres), Mook-Kanamori, D. O. (Dennis O.), Mori, T. A. (Trevor A.), Munroe, P. B. (Patricia B.), Njolstad, I. (Inger), O'Connell, J. R. (Jeffrey R.), Oldehinkel, A. J. (Albertine J.), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Palmer, C. N. (Colin N. A.), Palmer, N. D. (Nicholette D.), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Porteous, D. J. (David J.), Pramstaller, P. P. (Peter P.), Province, M. A. (Michael A.), Psaty, B. M. (Bruce M.), Qi, L. (Lu), Raffel, L. J. (Leslie J.), Rauramaa, R. (Rainer), Redline, S. (Susan), Ridker, P. M. (Paul M.), Rosendaal, F. R. (Frits R.), Saaristo, T. E. (Timo E.), Sandhu, M. (Manjinder), Saramies, J. (Jouko), Schneiderman, N. (Neil), Schwarz, P. (Peter), Scott, L. J. (Laura J.), Selvin, E. (Elizabeth), Sever, P. (Peter), Shu, X.-o. (Xiao-ou), Slagboom, P. E. (P. Eline), Small, K. S. (Kerrin S.), Smith, B. H. (Blair H.), Snieder, H. (Harold), Sofer, T. (Tamar), Sorensen, T. I. (Thorkild I. A.), Spector, T. D. (Tim D.), Stanton, A. (Alice), Steves, C. J. (Claire J.), Stumvoll, M. (Michael), Sun, L. (Liang), Tabara, Y. (Yasuharu), Tai, E. S. (E. Shyong), Timpson, N. J. (Nicholas J.), Tonjes, A. (Anke), Tuomilehto, J. (Jaakko), Tusie, T. (Teresa), Uusitupa, M. (Matti), van der Harst, P. (Pim), van Duijn, C. (Cornelia), Vitart, V. (Veronique), Vollenweider, P. (Peter), Vrijkotte, T. G. (Tanja G. M.), Wagenknecht, L. E. (Lynne E.), Walker, M. (Mark), Wang, Y. X. (Ya X.), Wareham, N. J. (Nick J.), Watanabe, R. M. (Richard M.), Watkins, H. (Hugh), Wei, W. B. (Wen B.), Wickremasinghe, A. R. (Ananda R.), Willemsen, G. (Gonneke), Wilson, J. F. (James F.), Wong, T.-Y. (Tien-Yin), Wu, J.-Y. (Jer-Yuarn), Xiang, A. H. (Anny H.), Yanek, L. R. (Lisa R.), Yengo, L. (Loic), Yokota, M. (Mitsuhiro), Zeggini, E. (Eleftheria), Zheng, W. (Wei), Zonderman, A. B. (Alan B.), Rotter, J. I. (Jerome I.), Gloyn, A. L. (Anna L.), McCarthy, M. I. (Mark I.), Dupuis, J. (Josee), Meigs, J. B. (James B.), Scott, R. A. (Robert A.), Prokopenko, I. (Inga), Leong, A. (Aaron), Liu, C.-T. (Ching-Ti), Parker, S. C. (Stephen C. J.), Mohlke, K. L. (Karen L.), Langenberg, C. (Claudia), Wheeler, E. (Eleanor), Morris, A. P. (Andrew P.), Barroso, I. (Ines), Chen, J. (Ji), Spracklen, C. N. (Cassandra N.), Marenne, G. (Gaelle), Varshney, A. (Arushi), Corbin, L. J. (Laura J.), Luan, J. (Jian'an), Willems, S. M. (Sara M.), Wu, Y. (Ying), Zhang, X. (Xiaoshuai), Horikoshi, M. (Momoko), Boutin, T. S. (Thibaud S.), Magi, R. (Reedik), Waage, J. (Johannes), Li-Gao, R. (Ruifang), Chan, K. H. (Kei Hang Katie), Yao, J. (Jie), Anasanti, M. D. (Mila D.), Chu, A. Y. (Audrey Y.), Claringbould, A. (Annique), Heikkinen, J. (Jani), Hong, J. (Jaeyoung), Hottenga, J.-J. (Jouke-Jan), Huo, S. (Shaofeng), Kaakinen, M. A. (Marika A.), Louie, T. (Tin), Maerz, W. (Winfried), Moreno-Macias, H. (Hortensia), Ndungu, A. (Anne), Nelson, S. C. (Sarah C.), Nolte, I. M. (Ilja M.), North, K. E. (Kari E.), Raulerson, C. K. (Chelsea K.), Ray, D. (Debashree), Rohde, R. (Rebecca), Rybin, D. (Denis), Schurmann, C. (Claudia), Sim, X. (Xueling), Southam, L. (Lorraine), Stewart, I. D. (Isobel D.), Wang, C. A. (Carol A.), Wang, Y. (Yujie), Wu, P. (Peitao), Zhang, W. (Weihua), Ahluwalia, T. S. (Tarunveer S.), Appel, E. V. (Emil V. R.), Bielak, L. F. (Lawrence F.), Brody, J. A. (Jennifer A.), Burtt, N. P. (Noel P.), Cabrera, C. P. (Claudia P.), Cade, B. E. (Brian E.), Chai, J. F. (Jin Fang), Chai, X. (Xiaoran), Chang, L.-C. (Li-Ching), Chen, C.-H. (Chien-Hsiun), Chen, B. H. (Brian H.), Chitrala, K. N. (Kumaraswamy Naidu), Chiu, Y.-F. (Yen-Feng), de Haan, H. G. (Hugoline G.), Delgado, G. E. (Graciela E.), Demirkan, A. (Ayse), Duan, Q. (Qing), Engmann, J. (Jorgen), Fatumo, S. A. (Segun A.), Gayan, J. (Javier), Giulianini, F. (Franco), Gong, J. H. (Jung Ho), Gustafsson, S. (Stefan), Hai, Y. (Yang), Hartwig, F. P. (Fernando P.), He, J. (Jing), Heianza, Y. (Yoriko), Huang, T. (Tao), Huerta-Chagoya, A. (Alicia), Hwang, M. Y. (Mi Yeong), Jensen, R. A. (Richard A.), Kawaguchi, T. (Takahisa), Kentistou, K. A. (Katherine A.), Kim, Y. J. (Young Jin), Kleber, M. E. (Marcus E.), Kooner, I. K. (Ishminder K.), Lai, S. (Shuiqing), Lange, L. A. (Leslie A.), Langefeld, C. D. (Carl D.), Lauzon, M. (Marie), Li, M. (Man), Ligthart, S. (Symen), Liu, J. (Jun), Loh, M. (Marie), Long, J. (Jirong), Lyssenko, V. (Valeriya), Mangino, M. (Massimo), Marzi, C. (Carola), Montasser, M. E. (May E.), Nag, A. (Abhishek), Nakatochi, M. (Masahiro), Noce, D. (Damia), Noordam, R. (Raymond), Pistis, G. (Giorgio), Preuss, M. (Michael), Raffield, L. (Laura), Rasmussen-Torvik, L. J. (Laura J.), Rich, S. S. (Stephen S.), Robertson, N. R. (Neil R.), Rueedi, R. (Rico), Ryan, K. (Kathleen), Sanna, S. (Serena), Saxena, R. (Richa), Schraut, K. E. (Katharina E.), Sennblad, B. (Bengt), Setoh, K. (Kazuya), Smith, A. V. (Albert V.), Sparso, T. (Thomas), Strawbridge, R. J. (Rona J.), Takeuchi, F. (Fumihiko), Tan, J. (Jingyi), Trompet, S. (Stella), van den Akker, E. (Erik), van der Most, P. J. (Peter J.), Verweij, N. (Niek), Vogel, M. (Mandy), Wang, H. (Heming), Wang, C. (Chaolong), Wang, N. (Nan), Warren, H. R. (Helen R.), Wen, W. (Wanqing), Wilsgaard, T. (Tom), Wong, A. (Andrew), Wood, A. R. (Andrew R.), Xie, T. (Tian), Zafarmand, M. H. (Mohammad Hadi), Zhao, J.-H. (Jing-Hua), Zhao, W. (Wei), Amin, N. (Najaf), Arzumanyan, Z. (Zorayr), Astrup, A. (Arne), Bakker, S. J. (Stephan J. L.), Baldassarre, D. (Damiano), Beekman, M. (Marian), Bergman, R. N. (Richard N.), Bertoni, A. (Alain), Blueher, M. (Matthias), Bonnycastle, L. L. (Lori L.), Bornstein, S. R. (Stefan R.), Bowden, D. W. (Donald W.), Cai, Q. (Qiuyin), Campbell, A. (Archie), Campbell, H. (Harry), Chang, Y. C. (Yi Cheng), de Geus, E. J. (Eco J. C.), Dehghan, A. (Abbas), Du, S. (Shufa), Eiriksdottir, G. (Gudny), Farmaki, A. E. (Aliki Eleni), Franberg, M. (Mattias), Fuchsberger, C. (Christian), Gao, Y. (Yutang), Gjesing, A. P. (Anette P.), Goel, A. (Anuj), Han, S. (Sohee), Hartman, C. A. (Catharina A.), Herder, C. (Christian), Hicks, A. A. (Andrew A.), Hsieh, C.-H. (Chang-Hsun), Hsueh, W. A. (Willa A.), Ichihara, S. (Sahoko), Igase, M. (Michiya), Ikram, M. A. (M. Arfan), Johnson, W. C. (W. Craig), Jorgensen, M. E. (Marit E.), Joshi, P. K. (Peter K.), Kalyani, R. R. (Rita R.), Kandeel, F. R. (Fouad R.), Katsuya, T. (Tomohiro), Khor, C. C. (Chiea Chuen), Kiess, W. (Wieland), Kolcic, I. (Ivana), Kuulasmaa, T. (Teemu), Kuusisto, J. (Johanna), Lall, K. (Kristi), Lam, K. (Kelvin), Lawlor, D. A. (Deborah A.), Lee, N. R. (Nanette R.), Lemaitre, R. N. (Rozenn N.), Li, H. (Honglan), Lin, S.-Y. (Shih-Yi), Lindstrom, J. (Jaana), Linneberg, A. (Allan), Liu, J. (Jianjun), Lorenzo, C. (Carlos), Matsubara, T. (Tatsuaki), Matsuda, F. (Fumihiko), Mingrone, G. (Geltrude), Mooijaart, S. (Simon), Moon, S. (Sanghoon), Nabika, T. (Toru), Nadkarni, G. N. (Girish N.), Nadler, J. L. (Jerry L.), Nelis, M. (Mari), Neville, M. J. (Matt J.), Norris, J. M. (Jill M.), Ohyagi, Y. (Yasumasa), Peters, A. (Annette), Peyser, P. A. (Patricia A.), Polasek, O. (Ozren), Qi, Q. (Qibin), Raven, D. (Dennis), Reilly, D. F. (Dermot F.), Reiner, A. (Alex), Rivideneira, F. (Fernando), Roll, K. (Kathryn), Rudan, I. (Igor), Sabanayagam, C. (Charumathi), Sandow, K. (Kevin), Sattar, N. (Naveed), Schuermann, A. (Annette), Shi, J. (Jinxiu), Stringham, H. M. (Heather M.), Taylor, K. D. (Kent D.), Teslovich, T. M. (Tanya M.), Thuesen, B. (Betina), Timmers, P. R. (Paul R. H. J.), Tremoli, E. (Elena), Tsai, M. Y. (Michael Y.), Uitterlinden, A. (Andre), van Dam, R. M. (Rob M.), van Heemst, D. (Diana), van Hylckama Vlieg, A. (Astrid), van Vliet-Ostaptchouk, J. V. (Jana V.), Vangipurapu, J. (Jagadish), Vestergaard, H. (Henrik), Wang, T. (Tao), Willems van Dijk, K. (Ko), Zemunik, T. (Tatijana), Abecasis, G. R. (Goncalo R.), Adair, L. S. (Linda S.), Aguilar-Salinas, C. A. (Carlos Alberto), Alarcon-Riquelme, M. E. (Marta E.), An, P. (Ping), Aviles-Santa, L. (Larissa), Becker, D. M. (Diane M.), Beilin, L. J. (Lawrence J.), Bergmann, S. (Sven), Bisgaard, H. (Hans), Black, C. (Corri), Boehnke, M. (Michael), Boerwinkle, E. (Eric), Boehm, B. O. (Bernhard O.), Bonnelykke, K. (Klaus), Boomsma, D. I. (D. I.), Bottinger, E. P. (Erwin P.), Buchanan, T. A. (Thomas A.), Canouil, M. (Mickael), Caulfield, M. J. (Mark J.), Chambers, J. C. (John C.), Chasman, D. I. (Daniel I.), Chen, Y. I. (Yii-Der Ida), Cheng, C.-Y. (Ching-Yu), Collins, F. S. (Francis S.), Correa, A. (Adolfo), Cucca, F. (Francesco), de Silva, H. J. (H. Janaka), Dedoussis, G. (George), Elmstahl, S. (Solve), Evans, M. K. (Michele K.), Ferrannini, E. (Ele), Ferrucci, L. (Luigi), Florez, J. C. (Jose C.), Franks, P. W. (Paul W.), Frayling, T. M. (Timothy M.), Froguel, P. (Philippe), Gigante, B. (Bruna), Goodarzi, M. O. (Mark O.), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grarup, N. (Niels), Grimsgaard, S. (Sameline), Groop, L. (Leif), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Hamsten, A. (Anders), Hansen, T. (Torben), Hayward, C. (Caroline), Heckbert, S. R. (Susan R.), Horta, B. L. (Bernardo L.), Huang, W. (Wei), Ingelsson, E. (Erik), James, P. S. (Pankow S.), Järvelin, M.-R. (Marjo-Ritta), Jonas, J. B. (Jost B.), Jukema, J. W. (J. Wouter), Kaleebu, P. (Pontiano), Kaplan, R. (Robert), Kardia, S. L. (Sharon L. R.), Kato, N. (Norihiro), Keinanen-Kiukaanniemi, S. M. (Sirkka M.), Kim, B.-J. (Bong-Jo), Kivimaki, M. (Mika), Koistinen, H. A. (Heikki A.), Kooner, J. S. (Jaspal S.), Koerner, A. (Antje), Kovacs, P. (Peter), Kuh, D. (Diana), Kumari, M. (Meena), Kutalik, Z. (Zoltan), Laakso, M. (Markku), Lakka, T. A. (Timo A.), Launer, L. J. (Lenore J.), Leander, K. (Karin), Li, H. (Huaixing), Lin, X. (Xu), Lind, L. (Lars), Lindgren, C. (Cecilia), Liu, S. (Simin), Loos, R. J. (Ruth J. F.), Magnusson, P. K. (Patrik K. E.), Mahajan, A. (Anubha), Metspalu, A. (Andres), Mook-Kanamori, D. O. (Dennis O.), Mori, T. A. (Trevor A.), Munroe, P. B. (Patricia B.), Njolstad, I. (Inger), O'Connell, J. R. (Jeffrey R.), Oldehinkel, A. J. (Albertine J.), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Palmer, C. N. (Colin N. A.), Palmer, N. D. (Nicholette D.), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Porteous, D. J. (David J.), Pramstaller, P. P. (Peter P.), Province, M. A. (Michael A.), Psaty, B. M. (Bruce M.), Qi, L. (Lu), Raffel, L. J. (Leslie J.), Rauramaa, R. (Rainer), Redline, S. (Susan), Ridker, P. M. (Paul M.), Rosendaal, F. R. (Frits R.), Saaristo, T. E. (Timo E.), Sandhu, M. (Manjinder), Saramies, J. (Jouko), Schneiderman, N. (Neil), Schwarz, P. (Peter), Scott, L. J. (Laura J.), Selvin, E. (Elizabeth), Sever, P. (Peter), Shu, X.-o. (Xiao-ou), Slagboom, P. E. (P. Eline), Small, K. S. (Kerrin S.), Smith, B. H. (Blair H.), Snieder, H. (Harold), Sofer, T. (Tamar), Sorensen, T. I. (Thorkild I. A.), Spector, T. D. (Tim D.), Stanton, A. (Alice), Steves, C. J. (Claire J.), Stumvoll, M. (Michael), Sun, L. (Liang), Tabara, Y. (Yasuharu), Tai, E. S. (E. Shyong), Timpson, N. J. (Nicholas J.), Tonjes, A. (Anke), Tuomilehto, J. (Jaakko), Tusie, T. (Teresa), Uusitupa, M. (Matti), van der Harst, P. (Pim), van Duijn, C. (Cornelia), Vitart, V. (Veronique), Vollenweider, P. (Peter), Vrijkotte, T. G. (Tanja G. M.), Wagenknecht, L. E. (Lynne E.), Walker, M. (Mark), Wang, Y. X. (Ya X.), Wareham, N. J. (Nick J.), Watanabe, R. M. (Richard M.), Watkins, H. (Hugh), Wei, W. B. (Wen B.), Wickremasinghe, A. R. (Ananda R.), Willemsen, G. (Gonneke), Wilson, J. F. (James F.), Wong, T.-Y. (Tien-Yin), Wu, J.-Y. (Jer-Yuarn), Xiang, A. H. (Anny H.), Yanek, L. R. (Lisa R.), Yengo, L. (Loic), Yokota, M. (Mitsuhiro), Zeggini, E. (Eleftheria), Zheng, W. (Wei), Zonderman, A. B. (Alan B.), Rotter, J. I. (Jerome I.), Gloyn, A. L. (Anna L.), McCarthy, M. I. (Mark I.), Dupuis, J. (Josee), Meigs, J. B. (James B.), Scott, R. A. (Robert A.), Prokopenko, I. (Inga), Leong, A. (Aaron), Liu, C.-T. (Ching-Ti), Parker, S. C. (Stephen C. J.), Mohlke, K. L. (Karen L.), Langenberg, C. (Claudia), Wheeler, E. (Eleanor), Morris, A. P. (Andrew P.), and Barroso, I. (Ines)

Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

Published
2021

23. The trans-ancestral genomic architecture of glycemic traits

Author

Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J. -J., Huo, S., Kaakinen, M. A., Louie, T., Marz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Raulerson, C. K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I. D., Wang, C. A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T. S., Appel, E. V. R., Bielak, L. F., Brody, J. A., Burtt, N. P., Cabrera, C. P., Cade, B. E., Chai, J. F., Chai, X., Chang, L. -C., Chen, C. -H., Chen, B. H., Chitrala, K. N., Chiu, Y. -F., de Haan, H. G., Delgado, G. E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S. A., Gayan, J., Giulianini, F., Gong, J. H., Gustafsson, S., Hai, Y., Hartwig, F. P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M. Y., Jensen, R. A., Kawaguchi, T., Kentistou, K. A., Kim, Y. J., Kleber, M. E., Kooner, I. K., Lai, S., Lange, L. A., Langefeld, C. D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M. E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L. J., Rich, S. S., Robertson, N. R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K. E., Sennblad, B., Setoh, K., Smith, A. V., Sparso, T., Strawbridge, R. J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P. J., Verweij, N., Vogel, M., Wang, H., Wang, Chin Heng, Wang, N., Warren, H. R., Wen, W., Wilsgaard, T., Wong, A., Wood, A. R., Xie, T., Zafarmand, M. H., Zhao, J. -H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, S. J. L., Baldassarre, D., Beekman, M., Bergman, R. N., Bertoni, Anna Marta Maria, Bluher, M., Bonnycastle, L. L., Bornstein, S. R., Bowden, D. W., Cai, Q., Campbell, A., Campbell, H., Chang, Y. C., de Geus, E. J. C., Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A. E., Franberg, M., Fuchsberger, C., Gao, Y., Gjesing, A. P., Goel, A., Han, S., Hartman, C. A., Herder, C., Hicks, A. A., Hsieh, C. -H., Hsueh, W. A., Ichihara, S., Igase, M., Ikram, M. A., Johnson, W. C., Jorgensen, M. E., Joshi, P. K., Kalyani, R. R., Kandeel, F. R., Katsuya, T., Khor, C. C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Lall, K., Lam, K., Lawlor, D. A., Lee, N. R., Lemaitre, R. N., Li, H., Lin, S. -Y., Lindstrom, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, Geltrude, Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G. N., Nadler, J. L., Nelis, M., Neville, M. J., Norris, J. M., Ohyagi, Y., Peters, A., Peyser, P. A., Polasek, O., Qi, Q., Raven, D., Reilly, D. F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schurmann, A., Shi, J., Stringham, H. M., Taylor, K. D., Teslovich, T. M., Thuesen, B., Timmers, P. R. H. J., Tremoli, Elena, Tsai, M. Y., Uitterlinden, A., van Dam, R. M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J. V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G. R., Adair, L. S., Aguilar-Salinas, C. A., Alarcon-Riquelme, M. E., An, P., Aviles-Santa, L., Becker, D. M., Beilin, L. J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Bohm, B. O., Bonnelykke, K., Boomsma, D. I., Bottinger, E. P., Buchanan, T. A., Canouil, M., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. -D. I., Cheng, C. -Y., Collins, F. S., Correa, A., Cucca, F., de Silva, H. J., Dedoussis, G., Elmstahl, S., Evans, M. K., Ferrannini, E., Ferrucci, L., Florez, J. C., Franks, P. W., Frayling, T. M., Froguel, P., Gigante, B., Goodarzi, M. O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S. R., Horta, B. L., Huang, W., Ingelsson, E., James, P. S., Jarvelin, M. -R., Jonas, J. B., Jukema, J. W., Kaleebu, P., Kaplan, R., Kardia, S. L. R., Kato, N., Keinanen-Kiukaanniemi, S. M., Kim, B. -J., Kivimaki, M., Koistinen, H. A., Kooner, J. S., Korner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T. A., Launer, L. J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, R. J. F., Magnusson, P. K. E., Mahajan, A., Metspalu, A., Mook-Kanamori, D. O., Mori, T. A., Munroe, P. B., Njolstad, I., O'Connell, J. R., Oldehinkel, A. J., Ong, K. K., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pedersen, O., Pennell, C. E., Porteous, D. J., Pramstaller, P. P., Province, M. A., Psaty, B. M., Qi, L., Raffel, L. J., Rauramaa, R., Redline, S., Ridker, P. M., Rosendaal, F. R., Saaristo, T. E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L. J., Selvin, E., Sever, P., Shu, X. -O., Slagboom, P. E., Small, K. S., Smith, B. H., Snieder, H., Sofer, T., Sorensen, T. I. A., Spector, T. D., Stanton, A., Steves, C. J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E. S., Timpson, N. J., Tonjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, T. G. M., Wagenknecht, L. E., Walker, M., Wang, Y. X., Wareham, N. J., Watanabe, R. M., Watkins, H., Wei, W. B., Wickremasinghe, A. R., Willemsen, G., Wilson, J. F., Wong, T. -Y., Wu, J. -Y., Xiang, A. H., Yanek, L. R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A. B., Rotter, J. I., Gloyn, A. L., Mccarthy, M. I., Dupuis, J., Meigs, J. B., Scott, R. A., Prokopenko, I., Leong, A., Liu, C. -T., Parker, S. C. J., Mohlke, K. L., Langenberg, C., Wheeler, E., Morris, A. P., Barroso, I., van Willems van Dijk, K., Wang C., Bertoni A. (ORCID:0000-0001-7228-8718), Mingrone G. (ORCID:0000-0003-2021-528X), Tremoli E., Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J. -J., Huo, S., Kaakinen, M. A., Louie, T., Marz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Raulerson, C. K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I. D., Wang, C. A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T. S., Appel, E. V. R., Bielak, L. F., Brody, J. A., Burtt, N. P., Cabrera, C. P., Cade, B. E., Chai, J. F., Chai, X., Chang, L. -C., Chen, C. -H., Chen, B. H., Chitrala, K. N., Chiu, Y. -F., de Haan, H. G., Delgado, G. E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S. A., Gayan, J., Giulianini, F., Gong, J. H., Gustafsson, S., Hai, Y., Hartwig, F. P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M. Y., Jensen, R. A., Kawaguchi, T., Kentistou, K. A., Kim, Y. J., Kleber, M. E., Kooner, I. K., Lai, S., Lange, L. A., Langefeld, C. D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M. E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L. J., Rich, S. S., Robertson, N. R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K. E., Sennblad, B., Setoh, K., Smith, A. V., Sparso, T., Strawbridge, R. J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P. J., Verweij, N., Vogel, M., Wang, H., Wang, Chin Heng, Wang, N., Warren, H. R., Wen, W., Wilsgaard, T., Wong, A., Wood, A. R., Xie, T., Zafarmand, M. H., Zhao, J. -H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, S. J. L., Baldassarre, D., Beekman, M., Bergman, R. N., Bertoni, Anna Marta Maria, Bluher, M., Bonnycastle, L. L., Bornstein, S. R., Bowden, D. W., Cai, Q., Campbell, A., Campbell, H., Chang, Y. C., de Geus, E. J. C., Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A. E., Franberg, M., Fuchsberger, C., Gao, Y., Gjesing, A. P., Goel, A., Han, S., Hartman, C. A., Herder, C., Hicks, A. A., Hsieh, C. -H., Hsueh, W. A., Ichihara, S., Igase, M., Ikram, M. A., Johnson, W. C., Jorgensen, M. E., Joshi, P. K., Kalyani, R. R., Kandeel, F. R., Katsuya, T., Khor, C. C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Lall, K., Lam, K., Lawlor, D. A., Lee, N. R., Lemaitre, R. N., Li, H., Lin, S. -Y., Lindstrom, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, Geltrude, Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G. N., Nadler, J. L., Nelis, M., Neville, M. J., Norris, J. M., Ohyagi, Y., Peters, A., Peyser, P. A., Polasek, O., Qi, Q., Raven, D., Reilly, D. F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schurmann, A., Shi, J., Stringham, H. M., Taylor, K. D., Teslovich, T. M., Thuesen, B., Timmers, P. R. H. J., Tremoli, Elena, Tsai, M. Y., Uitterlinden, A., van Dam, R. M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J. V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G. R., Adair, L. S., Aguilar-Salinas, C. A., Alarcon-Riquelme, M. E., An, P., Aviles-Santa, L., Becker, D. M., Beilin, L. J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Bohm, B. O., Bonnelykke, K., Boomsma, D. I., Bottinger, E. P., Buchanan, T. A., Canouil, M., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. -D. I., Cheng, C. -Y., Collins, F. S., Correa, A., Cucca, F., de Silva, H. J., Dedoussis, G., Elmstahl, S., Evans, M. K., Ferrannini, E., Ferrucci, L., Florez, J. C., Franks, P. W., Frayling, T. M., Froguel, P., Gigante, B., Goodarzi, M. O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S. R., Horta, B. L., Huang, W., Ingelsson, E., James, P. S., Jarvelin, M. -R., Jonas, J. B., Jukema, J. W., Kaleebu, P., Kaplan, R., Kardia, S. L. R., Kato, N., Keinanen-Kiukaanniemi, S. M., Kim, B. -J., Kivimaki, M., Koistinen, H. A., Kooner, J. S., Korner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T. A., Launer, L. J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, R. J. F., Magnusson, P. K. E., Mahajan, A., Metspalu, A., Mook-Kanamori, D. O., Mori, T. A., Munroe, P. B., Njolstad, I., O'Connell, J. R., Oldehinkel, A. J., Ong, K. K., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pedersen, O., Pennell, C. E., Porteous, D. J., Pramstaller, P. P., Province, M. A., Psaty, B. M., Qi, L., Raffel, L. J., Rauramaa, R., Redline, S., Ridker, P. M., Rosendaal, F. R., Saaristo, T. E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L. J., Selvin, E., Sever, P., Shu, X. -O., Slagboom, P. E., Small, K. S., Smith, B. H., Snieder, H., Sofer, T., Sorensen, T. I. A., Spector, T. D., Stanton, A., Steves, C. J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E. S., Timpson, N. J., Tonjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, T. G. M., Wagenknecht, L. E., Walker, M., Wang, Y. X., Wareham, N. J., Watanabe, R. M., Watkins, H., Wei, W. B., Wickremasinghe, A. R., Willemsen, G., Wilson, J. F., Wong, T. -Y., Wu, J. -Y., Xiang, A. H., Yanek, L. R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A. B., Rotter, J. I., Gloyn, A. L., Mccarthy, M. I., Dupuis, J., Meigs, J. B., Scott, R. A., Prokopenko, I., Leong, A., Liu, C. -T., Parker, S. C. J., Mohlke, K. L., Langenberg, C., Wheeler, E., Morris, A. P., Barroso, I., van Willems van Dijk, K., Wang C., Bertoni A. (ORCID:0000-0001-7228-8718), Mingrone G. (ORCID:0000-0003-2021-528X), and Tremoli E.

Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

Published
2021

27. Irish college of ophthalmologists: Proceedings of annual meeting held in Slieve Russell Hotel, Ballyconnell, Co. Cavan on May 4th and 5th, 1995

Author

Abdulla, N., Lanigan, B., O’Keefe, M., Bowell, R., Abdulla, N., Lanigan, B., Bowell, R., O’Keefe, M., Aduriz-Lorenzo, P. M., Acheson, R. W., Aduriz-Lorenzo, P. M., Logan, P., Eustace, P., Toland, J., Beatty, S., Kheterpal, S., Eagling, E. M., O’Neill, E. C., Beatty, S., Aggarwal, R. K., David, D. B., Jones, H., Guarro, M., Pearce, J. L., Best, R. M., Bailie, J. R., Stitt, A. W., Hadden, D. R., Traub, A. I., Chakravarthy, U., Archer, D. B., Cahil, M., Acheson, R. W., Mooney, D., Peyton, K., Cassidy, L., Barry, P., Early, A., Blayney, A., Stack, S., Eustace, P., Fenton, S., Collum, A., Hurley, C., Collum, L. M. T., Foley-Nolan, A., Foley-Nolan, A., O’Keefe, M., Goggin, M., Algawi, K., Gregor, Z. J., Hedges, T. R., Hurley, C., Hillery, M., Hoh, H. B., Claoue, C., Easty, D. L., Kenna, P., Collum, L. M. T., Keenan, J. M., Kriss, A., Harris, C., Clayton, P. T., Russell-Eggitt, I. R., Kilmartin, D. J., Mooney, D., Acheson, R. W., Payne, S., Maher, E. R., Eustace, P., Kilmartin, D. J., Moore, J., Silvestri, G., Acheson, R. W., Knight-Nanan, D. M., Algawi, K., O’Keefe, M., Larkin, D. F. P., George, A. J. T., Larkin, G., Olver, J., Lund, V., Fells, P., Lee, J. P., Lewis, H., Minihan, M., Horgan, T., Cleary, P. E., Mulholland, D. A., Earley, O. T., Sharkey, J. A., Atkinson, G., Mullaney, P. B., Noble, B. A., James, T. E., O’Brannagain, D., Nelson, E. I., O’Regan, R., O’Regan, R., Power, W. J., Dutt, J. E., Foster, C. S., Saidléar, C., Gilligan, P., Robinson, E., Ennis, J., Eustace, P., Sharkey, J. A., Sinton, J. E., Jackson, J., Frazer, D. G., Stitt, A., Gardiner, W. T. A., Archer, D. B., Weiser, B., O’Brien, C., Butt, Z., Beatty, S., Murray, P. I., Beatty, S., Nischal, K., Cahill, M., O’Meara, N., Mooney, D., Acheson, R. W., Chuah, K., Lyness, R., Earley, O. T., Datta, K., Fulcher, T., O’Keefe, M., Lacey, B., Earley, O. T., Buchanan, T. A. S., Lacey, B., Best, R. M., Earley, O. T., Johnston, P. B., Archer, D. B., Moore, J., Mahon, G., Limb, G. A., Buchanan, T. A. S., Kervick, G. N., Earley, O. T., Mulholland, D. A., Sharkey, J. A., Johnston, P. B., O’Regan, R., Nelson, E., Brannagain, D. O, and Irish Diabetic Study Group

Published
1995
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29. Neuroticism influences informant ratings of other people’s memory performance

Author

Buchanan, T. and Loveday, C.

Subjects
memory, informant report, neuroticism, proxy
Abstract

Informant-reports of cognitive performance may be influenced by factors other than the actual status of the individual being rated. Two studies tested the hypothesis that informant neuroticism was associated with higher ratings of a target’s memory problems. Study 1 found that more neurotic students rated their professor as having more memory problems. Study 2 found that more neurotic participants rated a participant in a simulated cognitive testing session as having more memory problems, but did not show any such biases in their estimates of how many mistakes were actually made in the testing session. These studies provide evidence that more neurotic individuals rate the memory performance of others as worse. This does not appear to be due to vigilance for objective indicators of cognitive performance. These findings may have implications for how informant-report measures are used in research and clinical practice.

Published
2020

30. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce

Author

Vogel, JP, Tendal, B, Giles, M, Whitehead, C, Burton, W, Chakraborty, S, Cheyne, S, Downton, T, Fraile Navarro, D, Gleeson, G, Gordon, A, Hunt, J, Kitschke, J, McDonald, S, McDonnell, N, Middleton, P, Millard, T, Murano, M, Oats, J, Tate, R, White, H, Elliott, J, Roach, V, Homer, CSE, McGowan, S, Ballenden, N, Barrett, TL, Beavis, V, Saunders, JB, Buchanan, T, Buchanan-Grey, M, Casey, D, Cowie, M, Doyle, J, Frydenberg, M, Gnjidic, D, Green, S, Greenland, R, Griffin, K, Groombridge, S, Hardy, L, Hodak, A, Holley, A, Jovanovska, V, Knight, S, Michaels, K, Morley, P, Morphet, J, Nou, S, Russo, P, Sarson, M, Young, A, Norris, S, Morris-Donovan, B, Gurry, S, Hudson, E, Hurley, S, Primmer, D, Timms, S, Whicker, S, Mukherjee, S, Agostino, J, Booth, K, Burr, L, Byers, L, Cameron, P, Cooper, M, Cheng, A, Fowler, P, Glanville, A, Leder, K, McGloughlin, S, McMullan, B, McPhee, E, Mitchell, B, Morgan, M, Myles, P, O’Donnell, C, Parr, M, Phillips, J, Randall, R, Varndell, W, Whyte, I, William, L, Brightwell, R, Condon, L, Deshpande, A, Ehm, A, Ferrie, M, Muller, J, Pullin, L, Robinson, E, Witt, A, Larkins, S, Taylor, G, Burgess, P, Vogel, JP, Tendal, B, Giles, M, Whitehead, C, Burton, W, Chakraborty, S, Cheyne, S, Downton, T, Fraile Navarro, D, Gleeson, G, Gordon, A, Hunt, J, Kitschke, J, McDonald, S, McDonnell, N, Middleton, P, Millard, T, Murano, M, Oats, J, Tate, R, White, H, Elliott, J, Roach, V, Homer, CSE, McGowan, S, Ballenden, N, Barrett, TL, Beavis, V, Saunders, JB, Buchanan, T, Buchanan-Grey, M, Casey, D, Cowie, M, Doyle, J, Frydenberg, M, Gnjidic, D, Green, S, Greenland, R, Griffin, K, Groombridge, S, Hardy, L, Hodak, A, Holley, A, Jovanovska, V, Knight, S, Michaels, K, Morley, P, Morphet, J, Nou, S, Russo, P, Sarson, M, Young, A, Norris, S, Morris-Donovan, B, Gurry, S, Hudson, E, Hurley, S, Primmer, D, Timms, S, Whicker, S, Mukherjee, S, Agostino, J, Booth, K, Burr, L, Byers, L, Cameron, P, Cooper, M, Cheng, A, Fowler, P, Glanville, A, Leder, K, McGloughlin, S, McMullan, B, McPhee, E, Mitchell, B, Morgan, M, Myles, P, O’Donnell, C, Parr, M, Phillips, J, Randall, R, Varndell, W, Whyte, I, William, L, Brightwell, R, Condon, L, Deshpande, A, Ehm, A, Ferrie, M, Muller, J, Pullin, L, Robinson, E, Witt, A, Larkins, S, Taylor, G, and Burgess, P

Abstract

To date, 18 living recommendations for the clinical care of pregnant and postpartum women with COVID-19 have been issued by the National COVID-19 Clinical Evidence Taskforce. This includes recommendations on mode of birth, delayed umbilical cord clamping, skin-to-skin contact, breastfeeding, rooming-in, antenatal corticosteroids, angiotensin-converting enzyme inhibitors, disease-modifying treatments (including dexamethasone, remdesivir and hydroxychloroquine), venous thromboembolism prophylaxis and advanced respiratory support interventions (prone positioning and extracorporeal membrane oxygenation). Through continuous evidence surveillance, these living recommendations are updated in near real-time to ensure clinicians in Australia have reliable, evidence-based guidelines for clinical decision-making. Please visit https://covid19evidence.net.au/ for the latest recommendation updates.

Published
2020

31. Electronic cigarettes: A position statement from the Thoracic Society of Australia and New Zealand*.

Author

See H.V., Thompson B.R., Ween M.P., Peters M.J., Chapman D.G., Dobler C.C., Foster J.M., Hamor P., Hodge S., Holmes P.W., Larcombe A.N., Marshall H.M., McCallum G.B., Miller A., Pattemore P., Roseby R., Stone E., McDonald C.F., Jones S., Beckert L., Bonevski B., Buchanan T., Bozier J., Carson-Chahhoud K.V., See H.V., Thompson B.R., Ween M.P., Peters M.J., Chapman D.G., Dobler C.C., Foster J.M., Hamor P., Hodge S., Holmes P.W., Larcombe A.N., Marshall H.M., McCallum G.B., Miller A., Pattemore P., Roseby R., Stone E., McDonald C.F., Jones S., Beckert L., Bonevski B., Buchanan T., Bozier J., and Carson-Chahhoud K.V.

Abstract

The TSANZ develops position statements where insufficient data exist to write formal clinical guidelines. In 2018, the TSANZ addressed the question of potential benefits and health impacts of electronic cigarettes (EC). The working party included groups focused on health impacts, smoking cessation, youth issues and priority populations. The 2018 report on the Public Health Consequences of E-Cigarettes from the United States NASEM was accepted as reflective of evidence to mid-2017. A search for papers subsequently published in peer-reviewed journals was conducted in August 2018. A small number of robust and important papers published until March 2019 were also identified and included. Groups identified studies that extended, modified or contradicted the NASEM report. A total of 3793 papers were identified and reviewed, with summaries and draft position statements developed and presented to TSANZ membership in April 2019. After feedback from members and external reviewers, a collection of position statements was finalized in December 2019. EC have adverse lung effects and harmful effects of long-term use are unknown. EC are unsuitable consumer products for recreational use, part-substitution for smoking or long-term exclusive use by former smokers. Smokers who require support to quit smoking should be directed towards approved medication in conjunction with behavioural support as having the strongest evidence for efficacy and safety. No specific EC product can be recommended as effective and safe for smoking cessation. Smoking cessation claims in relation to EC should be assessed by established regulators.Copyright © 2020 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.

Published
2020

32. Electronic cigarettes: A position statement from the Thoracic Society of Australia and New Zealand*

Author

McDonald, CF, Jones, S, Beckert, L, Bonevski, B, Buchanan, T, Bozier, J, Carson-Chahhoud, K, Chapman, DG, Dobler, CC, Foster, JM, Hamor, P, Hodge, S, Holmes, PW, Larcombe, AN, Marshall, HM, McCallum, GB, Miller, A, Pattemore, P, Roseby, R, See, H, Stone, E, Thompson, BR, Ween, MP, Peters, MJ, McDonald, CF, Jones, S, Beckert, L, Bonevski, B, Buchanan, T, Bozier, J, Carson-Chahhoud, K, Chapman, DG, Dobler, CC, Foster, JM, Hamor, P, Hodge, S, Holmes, PW, Larcombe, AN, Marshall, HM, McCallum, GB, Miller, A, Pattemore, P, Roseby, R, See, H, Stone, E, Thompson, BR, Ween, MP, and Peters, MJ

Abstract

The TSANZ develops position statements where insufficient data exist to write formal clinical guidelines. In 2018, the TSANZ addressed the question of potential benefits and health impacts of electronic cigarettes (EC). The working party included groups focused on health impacts, smoking cessation, youth issues and priority populations. The 2018 report on the Public Health Consequences of E-Cigarettes from the United States NASEM was accepted as reflective of evidence to mid-2017. A search for papers subsequently published in peer-reviewed journals was conducted in August 2018. A small number of robust and important papers published until March 2019 were also identified and included. Groups identified studies that extended, modified or contradicted the NASEM report. A total of 3793 papers were identified and reviewed, with summaries and draft position statements developed and presented to TSANZ membership in April 2019. After feedback from members and external reviewers, a collection of position statements was finalized in December 2019. EC have adverse lung effects and harmful effects of long-term use are unknown. EC are unsuitable consumer products for recreational use, part-substitution for smoking or long-term exclusive use by former smokers. Smokers who require support to quit smoking should be directed towards approved medication in conjunction with behavioural support as having the strongest evidence for efficacy and safety. No specific EC product can be recommended as effective and safe for smoking cessation. Smoking cessation claims in relation to EC should be assessed by established regulators.

Published
2020

33. Electronic cigarettes: A position statement from the Thoracic Society of Australia and New Zealand.

Author

McDonald CF, Jones S, Beckert L, Bonevski B, Buchanan T, Bozier J, Carson-Chahhoud KV, Chapman DG, Dobler CC, Foster JM, Hamor P, Hodge S, Holmes PW, Larcombe AN, Marshall HM, McCallum GB, Miller A, Pattemore P, Roseby R, See HV, Stone E, Thompson BR, Ween MP, Peters MJ, McDonald CF, Jones S, Beckert L, Bonevski B, Buchanan T, Bozier J, Carson-Chahhoud KV, Chapman DG, Dobler CC, Foster JM, Hamor P, Hodge S, Holmes PW, Larcombe AN, Marshall HM, McCallum GB, Miller A, Pattemore P, Roseby R, See HV, Stone E, Thompson BR, Ween MP, and Peters MJ

Abstract

The TSANZ develops position statements where insufficient data exist to write formal clinical guidelines. In 2018, the TSANZ addressed the question of potential benefits and health impacts of electronic cigarettes (EC). The working party included groups focused on health impacts, smoking cessation, youth issues and priority populations. The 2018 report on the Public Health Consequences of E-Cigarettes from the United States NASEM was accepted as reflective of evidence to mid-2017. A search for papers subsequently published in peer-reviewed journals was conducted in August 2018. A small number of robust and important papers published until March 2019 were also identified and included. Groups identified studies that extended, modified or contradicted the NASEM report. A total of 3793 papers were identified and reviewed, with summaries and draft position statements developed and presented to TSANZ membership in April 2019. After feedback from members and external reviewers, a collection of position statements was finalized in December 2019. EC have adverse lung effects and harmful effects of long-term use are unknown. EC are unsuitable consumer products for recreational use, part-substitution for smoking or long-term exclusive use by former smokers. Smokers who require support to quit smoking should be directed towards approved medication in conjunction with behavioural support as having the strongest evidence for efficacy and safety. No specific EC product can be recommended as effective and safe for smoking cessation. Smoking cessation claims in relation to EC should be assessed by established regulators.

Published
2020

34. Electronic cigarettes: A position statement from the Thoracic Society of Australia and New Zealand*

Author

McDonald, C.F., Jones, S., Beckert, L., Bonevski, B., Buchanan, T., Bozier, J., Carson-Chahhoud, K.V., Chapman, D.G., Dobler, C.C., Foster, J.M., Hamor, P., Hodge, S., Holmes, P.W., Larcombe, Alexander, Marshall, H.M., McCallum, G.B., Miller, A., Pattemore, P., Roseby, R., See, H.V., Stone, E., Thompson, B.R., Ween, M.P., Peters, M.J., McDonald, C.F., Jones, S., Beckert, L., Bonevski, B., Buchanan, T., Bozier, J., Carson-Chahhoud, K.V., Chapman, D.G., Dobler, C.C., Foster, J.M., Hamor, P., Hodge, S., Holmes, P.W., Larcombe, Alexander, Marshall, H.M., McCallum, G.B., Miller, A., Pattemore, P., Roseby, R., See, H.V., Stone, E., Thompson, B.R., Ween, M.P., and Peters, M.J.

Abstract

The TSANZ develops position statements where insufficient data exist to write formal clinical guidelines. In 2018, the TSANZ addressed the question of potential benefits and health impacts of electronic cigarettes (EC). The working party included groups focused on health impacts, smoking cessation, youth issues and priority populations. The 2018 report on the Public Health Consequences of E-Cigarettes from the United States NASEM was accepted as reflective of evidence to mid-2017. A search for papers subsequently published in peer-reviewed journals was conducted in August 2018. A small number of robust and important papers published until March 2019 were also identified and included. Groups identified studies that extended, modified or contradicted the NASEM report. A total of 3793 papers were identified and reviewed, with summaries and draft position statements developed and presented to TSANZ membership in April 2019. After feedback from members and external reviewers, a collection of position statements was finalized in December 2019. EC have adverse lung effects and harmful effects of long-term use are unknown. EC are unsuitable consumer products for recreational use, part-substitution for smoking or long-term exclusive use by former smokers. Smokers who require support to quit smoking should be directed towards approved medication in conjunction with behavioural support as having the strongest evidence for efficacy and safety. No specific EC product can be recommended as effective and safe for smoking cessation. Smoking cessation claims in relation to EC should be assessed by established regulators.

Published
2020

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