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4. Identification of novel androgen receptor target genes in prostate cancer

Author

Gerald William L, Scher Howard I, Arasheben Armin, Tilley Wayne D, Cogan Jon P, Pregizer Steve, Barski Artem, Jia Li, Prescott Jennifer, Jariwala Unnati, Buchanan Grant, Coetzee Gerhard A, and Frenkel Baruch

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression. Results Using Chromatin Immunoprecipitation (ChIP) Display, we discovered 19 novel loci occupied by the AR in castrate resistant C4-2B PCa cells. Only four of the 19 AR-occupied regions were within 10-kb 5'-flanking regulatory sequences. Three were located up to 4-kb 3' of the nearest gene, eight were intragenic and four were in gene deserts. Whereas the AR occupied the same loci in C4-2B (castrate resistant) and LNCaP (androgen-dependent) PCa cells, differences between the two cell lines were observed in the response of nearby genes to androgens. Among the genes strongly stimulated by DHT in C4-2B cells – D-dopachrome tautomerase (DDT), Protein kinase C delta (PRKCD), Glutathione S- transferase theta 2 (GSTT2), Transient receptor potential cation channel subfamily V member 3 (TRPV3), and Pyrroline-5-carboxylate reductase 1 (PYCR1) – most were less strongly or hardly stimulated in LNCaP cells. Another AR target gene, ornithine aminotransferase (OAT), was AR-stimulated in a ligand-independent manner, since it was repressed by AR siRNA knockdown, but not stimulated by DHT. We also present evidence for in vivo AR-mediated regulation of several genes identified by ChIP Display. For example, PRKCD and PYCR1, which may contribute to PCa cell growth and survival, are expressed in PCa biopsies from primary tumors before and after ablation and in metastatic lesions in a manner consistent with AR-mediated stimulation. Conclusion AR genomic occupancy is similar between LNCaP and C4-2B cells and is not biased towards 5' gene flanking sequences. The AR transcriptionally regulates less than half the genes nearby AR-occupied regions, usually but not always, in a ligand-dependent manner. Most are stimulated and a few are repressed. In general, response is stronger in C4-2B compared to LNCaP cells. Some of the genes near AR-occupied regions appear to be regulated by the AR in vivo as evidenced by their expression levels in prostate cancer tumors of various stages. Several AR target genes discovered in the present study, for example PRKCD and PYCR1, may open avenues in PCa research and aid the development of new approaches for disease management.

Published
2007
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5. Formation of functional Tat translocases from heterologous components

Author

Widdick David A, Buchanan Grant, Guymer David, Hicks Matthew G, Caldelari Isabelle, Berks Ben C, and Palmer Tracy

Subjects
Microbiology, QR1-502
Abstract

Abstract Background The Tat pathway transports folded proteins across the cytoplasmic membrane of bacteria and the thylakoid membrane of plants. In Eschericha coli, Tat transport requires the integral membrane proteins TatA, TatB and TatC. In this study we have tested the ability of tat genes from the eubacterial species Pseudomonas syringae, Streptomyces coelicolor and Aquifex aeolicus, to compensate for the absence of the cognate E. coli tat gene, and thus to form functional Tat translocases with E. coli Tat components. Results All three subunits of the Tat system from the Gram positive organism Streptomyces coelicolor were able to form heterologous translocases with substantive Tat transport activity. However, only the TatA and TatB proteins of Pseudomonas syringae were able to functionally interact with the E. coli Tat system even though the two organisms are closely related. Of the Tat components from the phylogenetically distant hyperthermophillic bacterium Aquifex aeolicus only the TatA proteins showed any detectable level of heterologous functionality. The heterologously expressed TatA proteins of S. coelicolor and A. aeolicus were found exclusively in the membrane fraction. Conclusion Our results show that of the three Tat proteins, TatA is most likely to show cross-species complementation. By contrast, TatB and TatC do not always show cross-complementation, probably because they must recognise heterologous signal peptides. Since heterologously-expressed S. coelicolor TatA protein was functional and found only in the membrane fraction, it suggests that soluble forms of Streptomyces TatA reported by others do not play a role in protein export.

Published
2006
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6. A Profession within a Profession: Mentoring Ecology of Three New Zealand Primary Schools

Author

Fyall, Glenn, Cowan, Jackie, and Buchanan, Grant

Abstract

Employing Bronfenbrenner's (1996) ecological systems theory, this study investigated the ecological nuances of teacher mentoring in three New Zealand primary schools. Specifically, the study explored the mentoring experiences of three beginning teachers and their mentors, within their respective schools, in relation to the national mentoring and induction policy guidelines. The researchers employed a multiple case study design where data were collected through policy documentation and related literature; semi-structured interviews and field notes. Data were analysed thematically and the findings and subsequent discussion reveal that the participant schools struggled to interpret, negotiate and operationalise the national mentoring policy guidelines as they are intended. It is recommended that the participating schools' leadership, who are influenced by the Teaching Council of New Zealand's national mentoring policy documentation and have influence on their schools' mentoring policy and practice, should pay greater attention to the selection, training, support and resourcing of individual mentor teachers. In turn, this may lead to a greater understanding of "educative mentoring" that emphasises collaborative, democratic professional learning interactions through positive, reciprocal learning conversations based on principles of adult learning.

Published
2020
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10. Carpal Instability

Author

Buchanan, Grant S., Koester, Alan, Eltorai, Adam E. M., editor, Eberson, Craig P., editor, and Daniels, Alan H., editor

Published
2017
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11. Orthopedic Emergencies

Author

Iliev, Ilia, Buchanan, Grant, Shuler, Franklin, Eltorai, Adam E. M., editor, Eberson, Craig P., editor, and Daniels, Alan H., editor

Published
2017
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22. Data from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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23. Supplementary Figure 1 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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24. Supplementary Figure 3 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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25. Supplementary Figure 2 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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26. Supplementary Figure 5 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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27. Supplementary Table 2 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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28. Supplementary Figure 4 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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29. Supplementary Figure Legend from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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30. Supplementary Table 1 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
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31. Data from Androgen Receptor Inhibits Estrogen Receptor-α Activity and Is Prognostic in Breast Cancer

Author

Peters, Amelia A., primary, Buchanan, Grant, primary, Ricciardelli, Carmela, primary, Bianco-Miotto, Tina, primary, Centenera, Margaret M., primary, Harris, Jonathan M., primary, Jindal, Shalini, primary, Segara, Davendra, primary, Jia, Li, primary, Moore, Nicole L., primary, Henshall, Susan M., primary, Birrell, Stephen N., primary, Coetzee, Gerhard A., primary, Sutherland, Robert L., primary, Butler, Lisa M., primary, and Tilley, Wayne D., primary

Published
2023
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32. Supplementary Methods, Figure Legends 1-6 from Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression

Author

Wang, Qian, primary, Bailey, Charles G., primary, Ng, Cynthia, primary, Tiffen, Jessamy, primary, Thoeng, Annora, primary, Minhas, Vineet, primary, Lehman, Melanie L., primary, Hendy, Stephen C., primary, Buchanan, Grant, primary, Nelson, Colleen C., primary, Rasko, John E.J., primary, and Holst, Jeff, primary

Published
2023
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33. Data from Control of Androgen Receptor Signaling in Prostate Cancer by the Cochaperone Small Glutamine–Rich Tetratricopeptide Repeat Containing Protein α

Author

Buchanan, Grant, primary, Ricciardelli, Carmela, primary, Harris, Jonathan M., primary, Prescott, Jennifer, primary, Yu, Zoe Chiao-Li, primary, Jia, Li, primary, Butler, Lisa M., primary, Marshall, Villis R., primary, Scher, Howard I., primary, Gerald, William L., primary, Coetzee, Gerhard A., primary, and Tilley, Wayne D., primary

Published
2023
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34. Supplementary Tables 1-3 from Androgen Receptor Inhibits Estrogen Receptor-α Activity and Is Prognostic in Breast Cancer

Author

Peters, Amelia A., primary, Buchanan, Grant, primary, Ricciardelli, Carmela, primary, Bianco-Miotto, Tina, primary, Centenera, Margaret M., primary, Harris, Jonathan M., primary, Jindal, Shalini, primary, Segara, Davendra, primary, Jia, Li, primary, Moore, Nicole L., primary, Henshall, Susan M., primary, Birrell, Stephen N., primary, Coetzee, Gerhard A., primary, Sutherland, Robert L., primary, Butler, Lisa M., primary, and Tilley, Wayne D., primary

Published
2023
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35. Data from Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression

Author

Wang, Qian, primary, Bailey, Charles G., primary, Ng, Cynthia, primary, Tiffen, Jessamy, primary, Thoeng, Annora, primary, Minhas, Vineet, primary, Lehman, Melanie L., primary, Hendy, Stephen C., primary, Buchanan, Grant, primary, Nelson, Colleen C., primary, Rasko, John E.J., primary, and Holst, Jeff, primary

Published
2023
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36. Supplementary Data 1-4 from Control of Androgen Receptor Signaling in Prostate Cancer by the Cochaperone Small Glutamine–Rich Tetratricopeptide Repeat Containing Protein α

Author

Buchanan, Grant, primary, Ricciardelli, Carmela, primary, Harris, Jonathan M., primary, Prescott, Jennifer, primary, Yu, Zoe Chiao-Li, primary, Jia, Li, primary, Butler, Lisa M., primary, Marshall, Villis R., primary, Scher, Howard I., primary, Gerald, William L., primary, Coetzee, Gerhard A., primary, and Tilley, Wayne D., primary

Published
2023
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37. Supplementary Figures 1-6, Table 1 from Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression

Author

Wang, Qian, primary, Bailey, Charles G., primary, Ng, Cynthia, primary, Tiffen, Jessamy, primary, Thoeng, Annora, primary, Minhas, Vineet, primary, Lehman, Melanie L., primary, Hendy, Stephen C., primary, Buchanan, Grant, primary, Nelson, Colleen C., primary, Rasko, John E.J., primary, and Holst, Jeff, primary

Published
2023
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42. Insights from AR Gene Mutations

Author

Buchanan, Grant, Need, Eleanor F., Bianco-Miotto, Tina, Greenberg, Norman M., Scher, Howard I., Centenera, Margaret M., Butler, Lisa M., Robins, Diane M., Tilley, Wayne D., Mohler, James, editor, and Tindall, Donald, editor

Published
2009
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