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1,522 results on '"Buck, Andreas"'

17. Deep phenotyping as a contribution to personalized depression therapy: the GEParD and DaCFail protocols

Author

Lichter, Katharina, Klüpfel, Catherina, Stonawski, Saskia, Hommers, Leif, Blickle, Manuel, Burschka, Carolin, Das, Felix, Heißler, Marlene, Hellmuth, Anna, Helmel, Jaqueline, Kranemann, Leonie, Lechner, Karin, Lehrieder, Dominik, Sauter, Amelie, Schiele, Miriam A., Vijayakumar, Vithusha, von Broen, Michael, Weiß, Carolin, Morbach, Caroline, Störk, Stefan, Gelbrich, Götz, Heuschmann, Peter U., Higuchi, Takahiro, Buck, Andreas, Homola, György A., Pham, Mirko, Menke, Andreas, Domschke, Katharina, Kittel-Schneider, Sarah, and Deckert, Jürgen

Published
2023
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20. Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients

Author

Giesel, Frederik L, Kratochwil, Clemens, Schlittenhardt, Joel, Dendl, Katharina, Eiber, Matthias, Staudinger, Fabian, Kessler, Lukas, Fendler, Wolfgang P, Lindner, Thomas, Koerber, Stefan A, Cardinale, Jens, Sennung, David, Roehrich, Manuel, Debus, Juergen, Sathekge, Mike, Haberkorn, Uwe, Calais, Jeremie, Serfling, Sebastian, and Buck, Andreas L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Biomedical Imaging, Female, Fluorodeoxyglucose F18, Gallium Radioisotopes, Humans, Male, Middle Aged, Neoplasms, Positron Emission Tomography Computed Tomography, Retrospective Studies, Tissue Distribution, FAPI PET, CT, FDG PET, Cancer-associated fibroblast, Various cancer diseases, FAPI PET/CT, FDG PET/CT, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeFAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The purpose of this study is the head-to-head intra-individual comparison of 68Ga-FAPI versus standard-of-care 18F-FDG in PET/CT in organ biodistribution and tumor uptake in patients with various cancers.Material and methodsThis international retrospective multicenter analysis included PET/CT data from 71 patients from 6 centers who underwent both 68Ga-FAPI and 18F-FDG PET/CT within a median time interval of 10 days (range 1-89 days). Volumes of interest (VOIs) were manually drawn in normal organs and tumor lesions to quantify tracer uptake by SUVmax and SUVmean. Furthermore, tumor-to-background ratios (TBR) were generated (SUVmax tumor/ SUVmax organ).ResultsA total of 71 patients were studied of, which 28 were female and 43 male (median age 60). In 41 of 71 patients, the primary tumor was present. Forty-three of 71 patients exhibited 162 metastatic lesions. 68Ga-FAPI uptake in primary tumors and metastases was comparable to 18F-FDG in most cases. The SUVmax was significantly lower for 68Ga-FAPI than 18F-FDG in background tissues such as the brain, oral mucosa, myocardium, blood pool, liver, pancreas, and colon. Thus, 68Ga-FAPI TBRs were significantly higher than 18F-FDG TBRs in some sites, including liver and bone metastases.ConclusionQuantitative tumor uptake is comparable between 68Ga-FAPI and 18F-FDG, but lower background uptake in most normal organs results in equal or higher TBRs for 68Ga-FAPI. Thus, 68Ga-FAPI PET/CT may yield improved diagnostic information in various cancers and especially in tumor locations with high physiological 18F-FDG uptake.

Published
2021

22. Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Author

Leipold, Alexander M., Werner, Rudolf A., Düll, Johannes, Jung, Pius, John, Mara, Stanojkovska, Emilia, Zhou, Xiang, Hornburger, Hannah, Ruckdeschel, Anna, Dietrich, Oliver, Imdahl, Fabian, Krammer, Tobias, Knop, Stefan, Rosenwald, Andreas, Buck, Andreas, Sander, Leif Erik, Einsele, Hermann, Kortüm, K. Martin, Saliba, Antoine-Emmanuel, and Rasche, Leo

Published
2023
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30. European Association of Nuclear Medicine (EANM) Focus 4 consensus recommendations: molecular imaging and therapy in haematological tumours

Author

Nanni, Cristina, Kobe, Carsten, Baeßler, Bettina, Baues, Christian, Boellaard, Ronald, Borchmann, Peter, Buck, Andreas, Buvat, Irène, Chapuy, Björn, Cheson, Bruce D, Chrzan, Robert, Cottereau, Ann-Segolene, Dührsen, Ulrich, Eikenes, Live, Hutchings, Martin, Jurczak, Wojciech, Kraeber-Bodéré, Françoise, Lopci, Egesta, Luminari, Stefano, MacLennan, Steven, Mikhaeel, N George, Nijland, Marcel, Rodríguez-Otero, Paula, Treglia, Giorgio, Withofs, Nadia, Zamagni, Elena, Zinzani, Pier Luigi, Zijlstra, Josée M, Herrmann, Ken, and Kunikowska, Jolanta

Published
2023
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37. Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias - The prospective cross-sectional diagnostic test performance study FAMIAN

Author

Hahner, Stefanie, primary, Hartrampf, Philipp, additional, Beuschlein, Felix, additional, Miederer, Matthias, additional, Miehle, Konstanze, additional, Wiebke, Schlotelburg, additional, Fuss, Carmina Teresa, additional, Pflmger, Thomas, additional, Fottner, Christian, additional, Tonjes, Anke, additional, Herrmann, Ken, additional, Amthauer, Holger, additional, Schreckenberger, Mathias, additional, Sabri, Osama, additional, Werner, Johanna, additional, Reuter, Miriam, additional, Kircher, Stefan, additional, Arlt, Wiebke, additional, Fassnacht, Martin, additional, Buck, Andreas, additional, Muller, Hans Helge, additional, and Andreas, Schirbel, additional

Published
2024
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47. DNA Damage and Repair in PBMCs after Internal Ex Vivo Irradiation with [ 223 Ra]RaCl 2 and [ 177 Lu]LuCl 3 Mixtures.

Author

Strobel, Isabella, Schumann, Sarah, Müller, Jessica, Buck, Andreas K., Port, Matthias, Lassmann, Michael, Eberlein, Uta, and Scherthan, Harry

Abstract

The combination of high and low LET radionuclides has been tested in several patient studies to improve treatment response. Radionuclide mixtures can also be released in nuclear power plant accidents or nuclear bomb deployment. This study investigated the DNA damage response and DNA double-strand break (DSB) repair in peripheral blood mononuclear cells (PBMCs) after internal exposure of blood samples of 10 healthy volunteers to either no radiation (baseline) or different radionuclide mixtures of the α- and β-emitters [223Ra]RaCl2 and [177Lu]LuCl3, i.e., 25 mGy/75 mGy, 50 mGy/50 mGy and 75 mGy/25 mGy, respectively. DSB foci and γ-H2AX α-track enumeration directly after 1 h of exposure or after 4 h or 24 h of repair revealed that radiation-induced foci (RIF) and α-track induction in 100 cells was similar for mixed α/β and pure internal α- or β-irradiation, as were the repair rates for all radiation qualities. In contrast, the fraction of unrepaired RIF (Qβ) in PBMCs after mixed α/β-irradiation (50% 223Ra & 50% 177Lu: Qβ = 0.23 ± 0.10) was significantly elevated relative to pure β-irradiation (50 mGy: Qβ, pure = 0.06 ± 0.02), with a similar trend being noted for all mixtures. This α-dose-dependent increase in persistent foci likely relates to the formation of complex DNA damage that remains difficult to repair. [ABSTRACT FROM AUTHOR]

Published
2024
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