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1. 5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors

Author

Boutard, Nicolas, primary, Sabiniarz, Aleksandra, additional, Czerwińska, Klaudia, additional, Jarosz, Małgorzata, additional, Cierpich, Anna, additional, Kolasińska, Ewa, additional, Wiklik, Katarzyna, additional, Gluza, Karolina, additional, Commandeur, Claude, additional, Buda, Anna, additional, Stasiowska, Agata, additional, Bobowska, Aneta, additional, Galek, Mariusz, additional, Fabritius, Charles-Henry, additional, Bugaj, Marta, additional, Palacz, Edyta, additional, Mazan, Andrzej, additional, Zarębski, Adrian, additional, Krawczyńska, Karolina, additional, Żurawska, Małgorzata, additional, Zawadzki, Przemysław, additional, Milik, Mariusz, additional, Węgrzyn, Paulina, additional, Dobrzańska, Monika, additional, Brzózka, Krzysztof, additional, and Kowalczyk, Piotr, additional

Published
2019
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2. Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties

Author

Boutard, Nicolas, primary, Białas, Arkadiusz, additional, Sabiniarz, Aleksandra, additional, Guzik, Paweł, additional, Banaszak, Katarzyna, additional, Biela, Artur, additional, Bień, Marcin, additional, Buda, Anna, additional, Bugaj, Barbara, additional, Cieluch, Ewelina, additional, Cierpich, Anna, additional, Dudek, Łukasz, additional, Eggenweiler, Hans-Michael, additional, Fogt, Joanna, additional, Gaik, Monika, additional, Gondela, Andrzej, additional, Jakubiec, Krzysztof, additional, Jurzak, Mirek, additional, Kitlińska, Agata, additional, Kowalczyk, Piotr, additional, Kujawa, Maciej, additional, Kwiecińska, Katarzyna, additional, Leś, Marcin, additional, Lindemann, Ralph, additional, Maciuszek, Monika, additional, Mikulski, Maciej, additional, Niedziejko, Paulina, additional, Obara, Alicja, additional, Pawlik, Henryk, additional, Rzymski, Tomasz, additional, Sieprawska-Lupa, Magdalena, additional, Sowińska, Marta, additional, Szeremeta-Spisak, Joanna, additional, Stachowicz, Agata, additional, Tomczyk, Mateusz M., additional, Wiklik, Katarzyna, additional, Włoszczak, Łukasz, additional, Ziemiańska, Sylwia, additional, Zarębski, Adrian, additional, Brzózka, Krzysztof, additional, Nowak, Mateusz, additional, and Fabritius, Charles-Henry, additional

Published
2019
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3. 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists

Author

Fabritius, Charles-Henry, Pesonen, Ullamari, Messinger, Josef, Horvath, Raymond, Salo, Harri, Gałęzowski, Michał, Galek, Mariusz, Stefańska, Klaudia, Szeremeta-Spisak, Joanna, Olszak-Płachta, Marta, Buda, Anna, Adamczyk, Justyna, Król, Marcin, Prusis, Peteris, Sieprawska-Lupa, Magdalena, Mikulski, Maciej, Kuokkanen, Katja, Chapman, Hugh, Obuchowicz, Radosław, Korjamo, Timo, Jalava, Niina, and Nowak, Mateusz

Published
2016
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4. Discovery and Structure–Activity Relationships of N ‐Aryl 6‐Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors

Author

Boutard, Nicolas, primary, Białas, Arkadiusz, additional, Sabiniarz, Aleksandra, additional, Guzik, Paweł, additional, Banaszak, Katarzyna, additional, Biela, Artur, additional, Bień, Marcin, additional, Buda, Anna, additional, Bugaj, Barbara, additional, Cieluch, Ewelina, additional, Cierpich, Anna, additional, Dudek, Łukasz, additional, Eggenweiler, Hans‐Michael, additional, Fogt, Joanna, additional, Gaik, Monika, additional, Gondela, Andrzej, additional, Jakubiec, Krzysztof, additional, Jurzak, Mirek, additional, Kitlińska, Agata, additional, Kowalczyk, Piotr, additional, Kujawa, Maciej, additional, Kwiecińska, Katarzyna, additional, Leś, Marcin, additional, Lindemann, Ralph, additional, Maciuszek, Monika, additional, Mikulski, Maciej, additional, Niedziejko, Paulina, additional, Obara, Alicja, additional, Pawlik, Henryk, additional, Rzymski, Tomasz, additional, Sieprawska‐Lupa, Magdalena, additional, Sowińska, Marta, additional, Szeremeta‐Spisak, Joanna, additional, Stachowicz, Agata, additional, Tomczyk, Mateusz M., additional, Wiklik, Katarzyna, additional, Włoszczak, Łukasz, additional, Ziemiańska, Sylwia, additional, Zarębski, Adrian, additional, Brzózka, Krzysztof, additional, Nowak, Mateusz, additional, and Fabritius, Charles‐Henry, additional

Published
2018
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6. Discovery and Structure–Activity Relationships of N‐Aryl 6‐Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.

Author

Boutard, Nicolas, Białas, Arkadiusz, Sabiniarz, Aleksandra, Guzik, Paweł, Banaszak, Katarzyna, Biela, Artur, Bień, Marcin, Buda, Anna, Bugaj, Barbara, Cieluch, Ewelina, Cierpich, Anna, Dudek, Łukasz, Eggenweiler, Hans‐Michael, Fogt, Joanna, Gaik, Monika, Gondela, Andrzej, Jakubiec, Krzysztof, Jurzak, Mirek, Kitlińska, Agata, and Kowalczyk, Piotr

Published
2019
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7. 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT 6 receptor antagonists

Author

Fabritius, Charles-Henry, primary, Pesonen, Ullamari, additional, Messinger, Josef, additional, Horvath, Raymond, additional, Salo, Harri, additional, Gałęzowski, Michał, additional, Galek, Mariusz, additional, Stefańska, Klaudia, additional, Szeremeta-Spisak, Joanna, additional, Olszak-Płachta, Marta, additional, Buda, Anna, additional, Adamczyk, Justyna, additional, Król, Marcin, additional, Prusis, Peteris, additional, Sieprawska-Lupa, Magdalena, additional, Mikulski, Maciej, additional, Kuokkanen, Katja, additional, Chapman, Hugh, additional, Obuchowicz, Radosław, additional, Korjamo, Timo, additional, Jalava, Niina, additional, and Nowak, Mateusz, additional

Published
2016
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8. Aberrant Expression of PIWIL1 and PIWIL2 and Their Clinical Significance in Ductal Breast Carcinoma.

Author

Litwin M, Szczepańska-Buda A, Michałowska D, Grzegrzółka J, Piotrowska A, Gomułkiewicz A, Wojnar A, Dzięgiel P, and Witkiewicz W

Subjects
Adult, Aged, Aged, 80 and over, Argonaute Proteins genetics, Breast Neoplasms genetics, Breast Neoplasms pathology, Carcinoma, Ductal, Breast genetics, Carcinoma, Ductal, Breast pathology, Cohort Studies, Female, Humans, Immunohistochemistry, Middle Aged, Prognosis, RNA, Messenger biosynthesis, RNA, Messenger genetics, Real-Time Polymerase Chain Reaction, Argonaute Proteins biosynthesis, Breast Neoplasms metabolism, Carcinoma, Ductal, Breast metabolism
Abstract

Background/aim: P-Element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) are involved in epigenetic regulation of gene expression in germline cells. Aberrant expression of piRNA and PIWI proteins have been identified in various types of tumour cells. The aim of this study was to evaluate the expression profiles of PIWI-like protein-1, -2 (PIWIL1 and PIWIL2), their immunohistochemical (IHC) characteristics in ductal breast cancer, and determine their correlation with clinicopathological parameters of this type of cancer., Materials and Methods: Material for IHC studies comprised of 101 invasive ductal carcinoma (IDC) cases and 31 mastopathy tissues. Frozen fragments of paired tissue specimens (tumour and adjacent non-malignant breast tissue) taken from 55 patients with IDC and 18 samples of mastopathy were used for molecular studies using real-time polymerase chain reaction (RT-PCR)., Results: A statistically significantly higher level of PIWIL1 and PIWIL2 was found in IDC compared to mastopathy samples (p≤0.0001). Increased expression of PIWIL1 was correlated with increased PIWIL2 expression in breast cancer tissue. Surprisingly, PIWIL1 mRNA was detected only in cancer and mastopathy, but was not found in most normal breast tissues, although it is noteworthy that the PIWIL2 mRNA level was statistically significantly lower in mastopathy and IDC samples compared to normal breast tissues., Conclusion: Our results affirm the hypothesis that reactivation of PIWI expression in various caner types is crucial for cancer development., (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2018
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