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1. Short and Variable Lags

Author

Buda, G., Carvalho, V. M., Corsetti, G., Duarte, J. B., Hansen, S., Moura, A. S., Ortiz, A., Rodrigo, T., Rodríguez Mora, J. V., and Alves Da Silva, G.

Subjects
Economic activity, Event-study, Monetary policy, High-frequency data, Local projections, High-Frequency Data, Economic Activity, Monetary Policy, Local Projections
Abstract

We study the transmission of monetary policy shocks using daily consumption, corporate sales and employment series. We find that the economy responds at both short and long lags that are variable in economically significant ways. Consumption reacts in one week, reaches a local trough in one quarter, recovers, and declines again after three quarters. Sales follow a similar pattern, but the initial drop, while delayed (one month), is deeper. In contrast, employment falls monotonically for five quarters albeit with a smaller impact reaction. We show that these short lags are masked by time aggregation at lower —quarterly— frequencies.

Published
2023
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2. P20 LENALIDOMIDE MAINTENANCE AFTER VTD INDUCTION AND AUTOLOGOUS STEM CELL TRANSPLANTATION: PRELIMINARY RESULTS OF A REAL-LIFE STUDY INCLUDING 389 PATIENTS

Author

Barilà, G., primary, Pascarella, A., additional, Conticello, C., additional, Mina, R., additional, Marcon, C., additional, Fazio, F., additional, Cartia, C., additional, Buda, G., additional, Pilerci, S., additional, Rocchi, S., additional, Maroccia, A., additional, Sgherza, N., additional, Porrazzo, M., additional, Pescosta, N., additional, Furlan, A., additional, Scomazzon, E., additional, Mele, G., additional, Gentile, M., additional, Del Giudice, M.L., additional, Schininà, G., additional, Pavan, L., additional, De Cicco, G., additional, Casson, A., additional, Lisi, C., additional, Antonioli, E., additional, Mangiacavalli, S., additional, Musto, P., additional, Gay, F., additional, Zamagni, E., additional, Petrucci, M.T., additional, Di Raimondo, F., additional, Patriarca, F., additional, Bassan, R., additional, and Zambello, R., additional

Published
2023
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3. P48 CARFILZOMIB, LENALIDOMIDE AND DEXAMETHASONE IN RELAPSED REFRACTORY MULTIPLE MYELOMA: A PROSPECTIVE REAL-LIFE EXPERIENCE OF THE REGIONAL TUSCAN MYELOMA NETWORK (RTM)

Author

Attucci, I., primary, Antonioli, E., additional, Pilerci, S., additional, Buda, G., additional, Gozzetti, A., additional, Candi, V., additional, Simonetti, F., additional, Del Giudice, ML., additional, Ciofini, S., additional, Staderini, M., additional, Grammatico, S., additional, Buzzichelli, A., additional, Messeri, M., additional, Bocchia, M., additional, Galimberti, S., additional, and Vannucchi, AM, additional

Published
2023
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4. Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.

Author

Clavero, E., Sanchez-Maldonado, J.M., Macauda, A., Horst, R. ter, Sampaio-Marques, B., Jurczyszyn, A., Clay-Gilmour, A., Stein, A., Hildebrandt, M.A., Weinhold, N., Buda, G., García-Sanz, R., Tomczak, W., Vogel, U., Jerez, A., Zawirska, D., Wątek, M., Hofmann, J.N., Landi, S., Spinelli, J.J., Butrym, A., Kumar, A., Martínez-López, J., Galimberti, S., Sarasquete, M.E., Subocz, E., Iskierka-Jażdżewska, E., Giles, G.G., Rybicka-Ramos, M., Kruszewski, M., Abildgaard, N., Verdejo, F.G., Sánchez Rovira, P., Silva Filho, M.I. da, Kadar, K., Razny, M., Cozen, W., Pelosini, M., Jurado, M., Bhatti, P., Dudzinski, M., Druzd-Sitek, A., Orciuolo, E., Li, Y., Norman, A.D., Zaucha, J.M., Reis, R.M., Markiewicz, M., Rodríguez Sevilla, J.J., Andersen, V., Jamroziak, K., Hemminki, K., Berndt, S.I., Rajkumar, V., Mazur, G., Kumar, S.K., Ludovico, P., Nagler, A., Chanock, S.J., Dumontet, C., Machiela, M.J., Varkonyi, J., Camp, N.J., Ziv, E., Vangsted, A.J., Brown, E.E., Campa, D., Vachon, C.M., Netea, M.G., Canzian, F., Försti, A., Sainz, J., Clavero, E., Sanchez-Maldonado, J.M., Macauda, A., Horst, R. ter, Sampaio-Marques, B., Jurczyszyn, A., Clay-Gilmour, A., Stein, A., Hildebrandt, M.A., Weinhold, N., Buda, G., García-Sanz, R., Tomczak, W., Vogel, U., Jerez, A., Zawirska, D., Wątek, M., Hofmann, J.N., Landi, S., Spinelli, J.J., Butrym, A., Kumar, A., Martínez-López, J., Galimberti, S., Sarasquete, M.E., Subocz, E., Iskierka-Jażdżewska, E., Giles, G.G., Rybicka-Ramos, M., Kruszewski, M., Abildgaard, N., Verdejo, F.G., Sánchez Rovira, P., Silva Filho, M.I. da, Kadar, K., Razny, M., Cozen, W., Pelosini, M., Jurado, M., Bhatti, P., Dudzinski, M., Druzd-Sitek, A., Orciuolo, E., Li, Y., Norman, A.D., Zaucha, J.M., Reis, R.M., Markiewicz, M., Rodríguez Sevilla, J.J., Andersen, V., Jamroziak, K., Hemminki, K., Berndt, S.I., Rajkumar, V., Mazur, G., Kumar, S.K., Ludovico, P., Nagler, A., Chanock, S.J., Dumontet, C., Machiela, M.J., Varkonyi, J., Camp, N.J., Ziv, E., Vangsted, A.J., Brown, E.E., Campa, D., Vachon, C.M., Netea, M.G., Canzian, F., Försti, A., and Sainz, J.

Abstract

Item does not contain fulltext, Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promoting resistance to treatments. To date no studies have determined the impact of genetic variation in autophagy-related genes on MM risk. We performed meta-analysis of germline genetic data on 234 autophagy-related genes from three independent study populations including 13,387 subjects of European ancestry (6863 MM patients and 6524 controls) and examined correlations of statistically significant single nucleotide polymorphisms (SNPs; p < 1 × 10(-9)) with immune responses in whole blood, peripheral blood mononuclear cells (PBMCs), and monocyte-derived macrophages (MDM) from a large population of healthy donors from the Human Functional Genomic Project (HFGP). We identified SNPs in six loci, CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A associated with MM risk (p = 4.47 × 10(-4)-5.79 × 10(-14)). Mechanistically, we found that the ULK4(rs6599175) SNP correlated with circulating concentrations of vitamin D3 (p = 4.0 × 10(-4)), whereas the IKBKE(rs17433804) SNP correlated with the number of transitional CD24(+)CD38(+) B cells (p = 4.8 × 10(-4)) and circulating serum concentrations of Monocyte Chemoattractant Protein (MCP)-2 (p = 3.6 × 10(-4)). We also found that the CD46(rs1142469) SNP correlated with numbers of CD19(+) B cells, CD19(+)CD3(-) B cells, CD5(+)IgD(-) cells, IgM(-) cells, IgD(-)IgM(-) cells, and CD4(-)CD8(-) PBMCs (p = 4.9 × 10(-4)-8.6 × 10(-4)) and circulating concentrations of interleukin (IL)-20 (p = 0.00082). Finally, we observed that the CDKN2A(rs2811710) SNP correlated with levels of CD4(+)EMCD45RO(+)CD27(-) cells (p = 9.3 × 10(-4)). These results s

Published
2023

5. Identification of novel genetic loci for risk of multiple myeloma by functional annotation.

Author

Macauda, A., Briem, K., Clay-Gilmour, A., Cozen, W., Försti, A., Giaccherini, M., Corradi, C., Sainz, J., Niazi, Y., Horst, R. ter, Li, Y., Netea, M.G., Vogel, U., Hemminki, K., Slager, S.L., Varkonyi, J., Andersen, V., Iskierka-Jazdzewska, E., Mártinez-Lopez, J., Zaucha, J., Camp, N.J., Rajkumar, S.V., Druzd-Sitek, A., Bhatti, P., Chanock, S.J., Kumar, S.K., Subocz, E., Mazur, G., Landi, S., Machiela, M.J., Jerez, A., Norman, A.D., Hildebrandt, M.A., Kadar, K., Berndt, S.I., Ziv, E., Buda, G., Nagler, A., Dumontet, C., Raźny, M., Watek, M., Butrym, A., Grzasko, N., Dudzinski, M., Rybicka-Ramos, M., Matera, E.L., García-Sanz, R., Goldschmidt, H., Jamroziak, K., Jurczyszyn, A., Clavero, E., Giles, G.G., Pelosini, M., Zawirska, D., Kruszewski, M., Marques, H., Haastrup, E., Sánchez-Maldonado, J.M., Bertsch, U., Rymko, M., Raab, M.S., Brown, E.E., Hofmann, J.N., Vachon, C., Campa, D., Canzian, F., Macauda, A., Briem, K., Clay-Gilmour, A., Cozen, W., Försti, A., Giaccherini, M., Corradi, C., Sainz, J., Niazi, Y., Horst, R. ter, Li, Y., Netea, M.G., Vogel, U., Hemminki, K., Slager, S.L., Varkonyi, J., Andersen, V., Iskierka-Jazdzewska, E., Mártinez-Lopez, J., Zaucha, J., Camp, N.J., Rajkumar, S.V., Druzd-Sitek, A., Bhatti, P., Chanock, S.J., Kumar, S.K., Subocz, E., Mazur, G., Landi, S., Machiela, M.J., Jerez, A., Norman, A.D., Hildebrandt, M.A., Kadar, K., Berndt, S.I., Ziv, E., Buda, G., Nagler, A., Dumontet, C., Raźny, M., Watek, M., Butrym, A., Grzasko, N., Dudzinski, M., Rybicka-Ramos, M., Matera, E.L., García-Sanz, R., Goldschmidt, H., Jamroziak, K., Jurczyszyn, A., Clavero, E., Giles, G.G., Pelosini, M., Zawirska, D., Kruszewski, M., Marques, H., Haastrup, E., Sánchez-Maldonado, J.M., Bertsch, U., Rymko, M., Raab, M.S., Brown, E.E., Hofmann, J.N., Vachon, C., Campa, D., and Canzian, F.

Abstract

Contains fulltext : 299996.pdf (Publisher’s version ) (Open Access), 01 november 2023

Published
2023

6. National Accounts in a World of Naturally Occurring Data: A Proof of Concept for Consumption

Author

Buda, G., Hansen, S., Rodrigo, T., Carvalho, V. M., Ortiz, Á., and Mora, J. V. R.

Subjects
Naturally Occurring Data, Consumption Inequality, National Accounts, Consumption, Consumption Dynamics
Abstract

This paper provides a first proof of concept that naturally occurring transaction data, arising from the decentralized activity of millions of economic agents, can be harnessed to produce both traditional national accounts-like objects and novel representative economic statistics. We deploy comprehensive transaction-level data and its associated metadata arising from the universe of Spanish retail accounts of Banco Bilbao Vizcaya Argentaria (BBVA). We first organize the resulting 3 billion individual transactions by 1.8 million bank customers in a large and highly detailed representative consumption panel. Based on this, we then show that the aggregation of such data, once organized according to national accounting principles, can reproduce current official statistics on aggregate consumption in the national accounts with a high degree of precision. As a result of the richness of the transaction data, we additionally show that such data can produce novel, highly detailed distributional accounts for consumption which show larger consumption inequality than surveys suggest, particularly in the right tail. Finally, we use the panel nature of the data to offer a non-parametric analysis of individual consumption dynamics which feature a significant degree of mean reversion. Moreover, the distribution of consumption growth has thick tails.

Published
2022
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7. Atrial amyloidosis: mechanisms and clinical manifestations

Author

Vergaro, G, Aimo, A, Rapezzi, C, Castiglione, V, Fabiani, I, Pucci, A, Buda, G, Passino, C, Lupon, J, Bayes-Genis, A, Emdin, M, and Braunwald, E

Subjects
Atrial disease, Heart, Amyloidosis, Natriuretic peptides, Atrial fibrillation
Abstract

Cardiac amyloidosis (CA) is now recognized as an important cause of heart failure. Increased wall thickness and diastolic dysfunction of the left ventricle are the most easily detectable manifestations of CA, but amyloid accumulates in all cardiac structures. Involvement of the left and right atria may be due to the haemodynamic effects of ventricular diastolic dysfunction, the effects of amyloid infiltration into the atrial wall, and the cardiotoxic damage of atrial cardiomyocytes by amyloid precursors. Atrial amyloidosis is an early manifestation of CA, and is associated with an increased risk of atrial fibrillation and thromboembolic events. Furthermore, atrial amyloidosis can be found even in the absence of systemic disease and ventricular involvement. This condition is named isolated atrial amyloidosis and is due to a local overproduction of atrial natriuretic peptide. In this review we summarize the evidence on the mechanisms and clinical relevance of atrial amyloidosis.

Published
2022

9. Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.

Author

Vachon C.M., Canzian F., Campa D., Watek M., Jurczyszyn A., Brown E.E., Berndt S., Butrym A., Norman A.D., Gemignani F., Slager S.L., Macauda A., Piredda C., Clay-Gilmour A.I., Sainz J., Buda G., Markiewicz M., Barington T., Ziv E., Hildebrandt M.A.T., Belachew A.A., Varkonyi J., Prejzner W., Druzd-Sitek A., Spinelli J., Andersen N.F., Hofmann J.N., Dudzinski M., Martinez-Lopez J., Iskierka-Jazdzewska E., Milne R.L., Mazur G., Giles G.G., Ebbesen L.H., Rymko M., Jamroziak K., Subocz E., Reis R.M., Garcia-Sanz R., Suska A., Haastrup E.K., Zawirska D., Grzasko N., Vangsted A.J., Dumontet C., Kruszewski M., Dutka M., Camp N.J., Waller R.G., Tomczak W., Pelosini M., Razny M., Marques H., Abildgaard N., Vachon C.M., Canzian F., Campa D., Watek M., Jurczyszyn A., Brown E.E., Berndt S., Butrym A., Norman A.D., Gemignani F., Slager S.L., Macauda A., Piredda C., Clay-Gilmour A.I., Sainz J., Buda G., Markiewicz M., Barington T., Ziv E., Hildebrandt M.A.T., Belachew A.A., Varkonyi J., Prejzner W., Druzd-Sitek A., Spinelli J., Andersen N.F., Hofmann J.N., Dudzinski M., Martinez-Lopez J., Iskierka-Jazdzewska E., Milne R.L., Mazur G., Giles G.G., Ebbesen L.H., Rymko M., Jamroziak K., Subocz E., Reis R.M., Garcia-Sanz R., Suska A., Haastrup E.K., Zawirska D., Grzasko N., Vangsted A.J., Dumontet C., Kruszewski M., Dutka M., Camp N.J., Waller R.G., Tomczak W., Pelosini M., Razny M., Marques H., and Abildgaard N.

Abstract

Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as expression quantitative trait loci (eQTLs) showing strong associations with gene expression levels. We performed an association study to test whether eQTLs of genes reported to be associated with prognosis of MM patients are directly associated with measures of adverse outcome. Using the genotype-tissue expression portal, we identified a total of 16 candidate genes with at least one eQTL SNP associated with their expression with P < 10-7 either in EBV-transformed B-lymphocytes or whole blood. We genotyped the resulting 22 SNPs in 1327 MM cases from the International Multiple Myeloma rESEarch (IMMEnSE) consortium and examined their association with overall survival (OS) and progression-free survival (PFS), adjusting for age, sex, country of origin and disease stage. Three polymorphisms in two genes (TBRG4-rs1992292, TBRG4-rs2287535 and ENTPD1-rs2153913) showed associations with OS at P <.05, with the former two also associated with PFS. The associations of two polymorphisms in TBRG4 with OS were replicated in 1277 MM cases from the International Lymphoma Epidemiology (InterLymph) Consortium. A meta-analysis of the data from IMMEnSE and InterLymph (2579 cases) showed that TBRG4-rs1992292 is associated with OS (hazard ratio = 1.14, 95% confidence interval 1.04-1.26, P =.007). In conclusion, we found biologically a plausible association between a SNP in TBRG4 and OS of MM patients.Copyright © 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.

Published
2021

10. Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients

Author

Macauda, A, Piredda, C, Clay-Gilmour, A, Sainz, J, Buda, G, Markiewicz, M, Barington, T, Ziv, E, Hildebrandt, MAT, Belachew, AA, Varkonyi, J, Prejzner, W, Druzd-Sitek, A, Spinelli, J, Andersen, NF, Hofmann, JN, Dudzinski, M, Martinez-Lopez, J, Iskierka-Jazdzewska, E, Milne, RL, Mazur, G, Giles, GG, Ebbesen, LH, Rymko, M, Jamroziak, K, Subocz, E, Reis, RM, Garcia-Sanz, R, Suska, A, Haastrup, EK, Zawirska, D, Grzasko, N, Vangsted, AJ, Dumontet, C, Kruszewski, M, Dutka, M, Camp, NJ, Waller, RG, Tomczak, W, Pelosini, M, Razny, M, Marques, H, Abildgaard, N, Watek, M, Jurczyszyn, A, Brown, EE, Berndt, S, Butrym, A, Vachon, CM, Norman, AD, Slager, SL, Gemignani, F, Canzian, F, Campa, D, Macauda, A, Piredda, C, Clay-Gilmour, A, Sainz, J, Buda, G, Markiewicz, M, Barington, T, Ziv, E, Hildebrandt, MAT, Belachew, AA, Varkonyi, J, Prejzner, W, Druzd-Sitek, A, Spinelli, J, Andersen, NF, Hofmann, JN, Dudzinski, M, Martinez-Lopez, J, Iskierka-Jazdzewska, E, Milne, RL, Mazur, G, Giles, GG, Ebbesen, LH, Rymko, M, Jamroziak, K, Subocz, E, Reis, RM, Garcia-Sanz, R, Suska, A, Haastrup, EK, Zawirska, D, Grzasko, N, Vangsted, AJ, Dumontet, C, Kruszewski, M, Dutka, M, Camp, NJ, Waller, RG, Tomczak, W, Pelosini, M, Razny, M, Marques, H, Abildgaard, N, Watek, M, Jurczyszyn, A, Brown, EE, Berndt, S, Butrym, A, Vachon, CM, Norman, AD, Slager, SL, Gemignani, F, Canzian, F, and Campa, D

Abstract

Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as expression quantitative trait loci (eQTLs) showing strong associations with gene expression levels. We performed an association study to test whether eQTLs of genes reported to be associated with prognosis of MM patients are directly associated with measures of adverse outcome. Using the genotype-tissue expression portal, we identified a total of 16 candidate genes with at least one eQTL SNP associated with their expression with P < 10-7 either in EBV-transformed B-lymphocytes or whole blood. We genotyped the resulting 22 SNPs in 1327 MM cases from the International Multiple Myeloma rESEarch (IMMEnSE) consortium and examined their association with overall survival (OS) and progression-free survival (PFS), adjusting for age, sex, country of origin and disease stage. Three polymorphisms in two genes (TBRG4-rs1992292, TBRG4-rs2287535 and ENTPD1-rs2153913) showed associations with OS at P < .05, with the former two also associated with PFS. The associations of two polymorphisms in TBRG4 with OS were replicated in 1277 MM cases from the International Lymphoma Epidemiology (InterLymph) Consortium. A meta-analysis of the data from IMMEnSE and InterLymph (2579 cases) showed that TBRG4-rs1992292 is associated with OS (hazard ratio = 1.14, 95% confidence interval 1.04-1.26, P = .007). In conclusion, we found biologically a plausible association between a SNP in TBRG4 and OS of MM patients.

Published
2021

11. Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case–control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium

Author

Martino, A, Campa, D, Buda, G, Sainz, J, García-Sanz, R, Jamroziak, K, Reis, R M, Weinhold, N, Jurado, M, Ríos, R, Szemraj-Rogucka, Z, Marques, H, Szemraj, J, Stein, A, Kumar, R, Orciuolo, E, Gemignani, F, Landi, S, Goldschmidt, H, Petrini, M, Dumontet, C, Canzian, F, and Rossi, A M

Published
2012
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15. Identification of concentrated damages in Euler-Bernoulli beams under static loads

Author

Buda, G. and Caddemi, S.

Subjects
Mechanical wear -- Research, Science and technology
Abstract

An identification procedure of concentrated damages in Euler-Bernoulli beams under static loads is presented in this work. The direct analysis problem is solved first by modeling concentrated damages as Dirac's delta distributions in the flexural stiffness. Closed-form solutions for both statically determinate and indeterminate beams are presented in terms of damage intensities and positions. On this basis, for the inverse damage identification problem, a nonquadratic optimization procedure is proposed. The presented procedure relies on the minimization of an error function measuring the error between the analytical model response and experimental data. The procedure allows to recognize 'a posteriori' some sufficient conditions for the uniqueness of the solution of the damage identification problem. The influence of the instrumental noise on the identified parameters is also explored. CE Database subject headings: Damage; Beams; Static loads; Parameters; Stiffness; Structural elements.

Published
2007

23. Interazione di onde e correnti su fondali scabri: Esperimenti preliminari

Author

Faraci, C., Petrotta, C., Buda, G., Calandro, E., Carlo, L., Galletta, B. A., Ruggeri, A., Foti, E., Musumeci, R. E., and Marino, M.

Subjects
ghiaiosi e coperti di ripples. Messa a punto del set up e della procedura sperimentale. Analisi sperimentale in condizioni sia current-dominated che wave-dominated. Determinazione dei profili di velocità lungo la verticale nelle 3 direzioni. Analisi in fase, Interazione di onde e correnti ortogonali su fondali sabbiosi, ghiaiosi e coperti di ripples. Messa a punto del set up e della procedura sperimentale. Analisi sperimentale in condizioni sia current-dominated che wave-dominated. Determinazione dei profili di velocità lungo la verticale nelle 3 direzioni. Analisi in fase, Interazione di onde e correnti ortogonali su fondali sabbiosi
Published
2018

31. Erratum: Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case—control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium

Author

Martino, A, Campa, D, Buda, G, Sainz, J, García-Sanz, R, Jamroziak, K, Reis, R M, Weinhold, N, Jurado, M, Ríos, R, Szemraj-Rogucka, Z, Marques, H, Szemraj, J, Stein, A, Kumar, R, Orciuolo, E, Gemignani, F, Landi, S, Goldschmidt, H, Petrini, M, Dumontet, C, Canzian, F, and Rossi, A M

Published
2013
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34. Cryo-EM Structure of Immature Zika Virus

Author

Mangala Prasad, V., primary, Miller, A.S., additional, Klose, T., additional, Sirohi, D., additional, Buda, G., additional, Jiang, W., additional, Kuhn, R.J., additional, and Rossmann, M.G., additional

Published
2017
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35. ACUTE T-LYMPHOBLASTIC LEUKEMIA/LYMPHOBLASTIC T-CELL LYMPHOMA. ROLE OF EARLY allo-SCT

Author

Iovino, L, Caracciolo, F., Orciuolo, E., Buda, G., Mazziotta, F., Rousseau, M., Galimberti, S., Benedetti, E., and Petrini, M.

Subjects
AL-T, allogeneic transplant, immunotherapy, allogeneic stem cell transplantation, ALL-T, allogeneic stem cell transplantation, immunotherapy, ALL-T, immunotherapy, AL-T, allogeneic transplant
Published
2015

36. Characteristics and outcome of therapy-related myeloid neoplasms: Report from the Italian network on secondary leukemias

Author

Fianchi, L, Pagano, L, Piciocchi, A, Candoni, A, Gaidano, G, Breccia, M, Criscuolo, M, Specchia, G, Maria Pogliani, E, Maurillo, L, ALOE SPIRITI, Maria Antonietta, Mecucci, C, Niscola, P, Rossetti, E, Mansueto, G, Rondoni, M, Fozza, C, Invernizzi, R, Spadea, A, Fenu, S, Buda, G, Gobbi, M, Fabiani, E, Sica, S, Hohaus, S, Leone, G, and Voso, Mt

Subjects
Myeloid, Homologous, Adult, Male, Topoisomerase Inhibitors, Karyotype, Antineoplastic Agents, Breast Neoplasms, Acute, secondary leukemia, Severity of Illness Index, 80 and over, Humans, Transplantation, Homologous, Prospective Studies, Antineoplastic Agents, Alkylating, Aged, Retrospective Studies, Aged, 80 and over, Transplantation, Leukemia, antimetabolite, Age Factors, Hematopoietic Stem Cell Transplantation, Anemia, Hematology, Middle Aged, Female, Gamma Rays, Leukemia, Myeloid, Acute, Lymphoproliferative Disorders, Survival Analysis, Alkylating, alkylating agent, cytotoxic agent, Settore MED/15 - Malattie del Sangue
Abstract

Therapy-related myeloid neoplasms (t-MN) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. We report data on 277 t-MN patients, recruited between 1999 and 2013 by the Italian Network on Secondary Leukemias (104 retrospectively and 173 prospectively registered). Median age at t-MN diagnosis was 64 years (range, 21-87). Most frequent primary malignancies (PMs) were lymphoproliferative diseases and breast cancer. One hundred and thirty-three patients had received chemotherapy (CHT), 43 patients radiotherapy (RT), and 101 patients combined CHT/RT for PM. Median time between cytotoxic treatment and t-MN was 5.7 years, with t-MN following RT alone associated with significantly longer latency, compared to CHT or combined CHT/RT (mean, 11.2 vs. 7.1 years, P = 0.0005). The addition of topoisomerase-II inhibitors to alkylating agents was associated with shorter latency compared to alkylating agents alone (median, 6 vs. 8.4 years, P = 0.02). Median survival was 14.6 months from t-MN diagnosis, and was significantly longer in patients treated with allogeneic stem cell transplantation. Significant factors for survival at the multivariable analysis included age, adverse karyotype, and degree of anemia. Our data underline the prognostic importance of karyotype and age in t-MN, similar to de novo acute myeloid leukemia. Treatment approaches should not preclude the use of conventional treatments for younger t-MN patients, including allogeneic stem cell transplantation as potentially curative approach.

Published
2015

38. Safety and efficacy of lenalidomide in combination with rituximab in recurrent indolent non-follicular lymphoma: final results of a phase II study conducted by the Fondazione Italiana Linfomi

Author

Sacchi, S., primary, Marcheselli, R., additional, Bari, A., additional, Buda, G., additional, Molinari, A. L., additional, Baldini, L., additional, Vallisa, D., additional, Cesaretti, M., additional, Musto, P., additional, Ronconi, S., additional, Specchia, G., additional, Silvestris, F., additional, Guardigni, L., additional, Ferrari, A., additional, Chiapella, A., additional, Carella, A. M., additional, Santoro, A., additional, Di Raimondo, F., additional, Marcheselli, L., additional, and Pozzi, S., additional

Published
2016
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39. Characteristics and outcome of therapy-related myeloid neoplasms: Report from the Italian network on secondary leukemias

Author

Fianchi, Luana, Pagano, Livio, Piciocchi, A, Candoni, A, Gaidano, G, Breccia, M, Criscuolo, M, Specchia, G, Maria Pogliani, E, Maurillo, L, Aloe Spiriti, Ma, Mecucci, C, Niscola, P, Rossetti, E, Mansueto, G, Rondoni, M, Fozza, C, Invernizzi, R, Spadea, A, Fenu, S, Buda, G, Gobbi, M, Fabiani, E, Sica, Simona, Hohaus, Stefan, Leone, G, Voso, Mt, Pagano, Livio (ORCID:0000-0001-8287-928X), Sica, Simona (ORCID:0000-0003-2426-3465), Hohaus, Stefan (ORCID:0000-0002-5534-7197), Fianchi, Luana, Pagano, Livio, Piciocchi, A, Candoni, A, Gaidano, G, Breccia, M, Criscuolo, M, Specchia, G, Maria Pogliani, E, Maurillo, L, Aloe Spiriti, Ma, Mecucci, C, Niscola, P, Rossetti, E, Mansueto, G, Rondoni, M, Fozza, C, Invernizzi, R, Spadea, A, Fenu, S, Buda, G, Gobbi, M, Fabiani, E, Sica, Simona, Hohaus, Stefan, Leone, G, Voso, Mt, Pagano, Livio (ORCID:0000-0001-8287-928X), Sica, Simona (ORCID:0000-0003-2426-3465), and Hohaus, Stefan (ORCID:0000-0002-5534-7197)

Abstract

Therapy-related myeloid neoplasms (t-MN) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. We report data on 277 t-MN patients, recruited between 1999 and 2013 by the Italian Network on Secondary Leukemias (104 retrospectively and 173 prospectively registered). Median age at t-MN diagnosis was 64 years (range, 21-87). Most frequent primary malignancies (PMs) were lymphoproliferative diseases and breast cancer. One hundred and thirty-three patients had received chemotherapy (CHT), 43 patients radiotherapy (RT), and 101 patients combined CHT/RT for PM. Median time between cytotoxic treatment and t-MN was 5.7 years, with t-MN following RT alone associated with significantly longer latency, compared to CHT or combined CHT/RT (mean, 11.2 vs. 7.1 years, P = 0.0005). The addition of topoisomerase-II inhibitors to alkylating agents was associated with shorter latency compared to alkylating agents alone (median, 6 vs. 8.4 years, P = 0.02). Median survival was 14.6 months from t-MN diagnosis, and was significantly longer in patients treated with allogeneic stem cell transplantation. Significant factors for survival at the multivariable analysis included age, adverse karyotype, and degree of anemia. Our data underline the prognostic importance of karyotype and age in t-MN, similar to de novo acute myeloid leukemia. Treatment approaches should not preclude the use of conventional treatments for younger t-MN patients, including allogeneic stem cell transplantation as potentially curative approach. Am. J. Hematol. 90:E80-E85, 2015. © 2015 Wiley Periodicals, Inc.

Published
2015

40. Risk factors for impaired gonadal function in female Hodgkin lymphoma survivors: final analysis of a retrospective multicenter joint study from Italian and Brazilian Institutions

Author

Falorio, S, Biasoli, I, Luminari, Stefano, Quintana, G, Musso, M, Dell'Olio, M, Specchia, Mr, di Renzo, N, Cesaretti, Marina, Buda, G, Vallisa, D, Mannina, D, Andriani, A, Chiattone, Cs, Delamain, Mt, de Souza CA, Spector, N, Angrilli, F, and Federico, Massimo

Subjects
fertility, Adult, Adolescent, Ovary, Hodgkin lymphoma, survivors, GnRH-a, Fertility Preservation, Hodgkin Disease, Survival Analysis, Young Adult, Italy, Risk Factors, Infertility, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Brazil, Contraceptives, Oral, Retrospective Studies
Abstract

Hodgkin lymphoma (HL) is one of the most common types of cancer in the young and one of the most curable forms of cancer. Therefore, there has been an increasing interest in the study of long-term morbidities. The aims of the present study were to evaluate the prevalence and risk factors for impaired gonadal function in a retrospective cohort of 238 HL female survivors from Italy and Brazil and to analyse the role of oral contraceptives (OC) and GnRH-analogues. Besides data collection from HL databases, a specific questionnaire was administered to collect data on gonadal function. The median age at diagnosis was 25 years and the median follow-up was 7 years. Overall, 25% of the patients developed impaired gonadal function. Older age at diagnosis, front-line therapies containing alkylating agents and more than one treatment were independent risk factors, whereas the use of OC or GnRH-a reduced independently the risk of impaired gonadal function. The fertility rate among fertile survivors was low when compared with the general population. We confirmed that older age, type of front-line chemotherapy and a higher number of therapies are associated with gonadal function impairment in terms of infertility and premature menopause in female HL survivors. Also, the use of GnRH-a or OC was independently identified as a protective factor. Further prospective studies are needed to better understand the barriers to parenthood in HL survivors.

Published
2012

43. Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk : a case--control study in the context of the International Q1 Multiple Myeloma rESEarch consortium

Author

Martino, A., Campa, D., Buda, G., Sainz, J., GarcIa Sanz, R., Jamroziak, K., Reis, R. M., Weinhold, N., Jurado, M., Rıos, R., Szemraj-Rogucka, Zofia, Marques, H., Szemraj, J., Stein, A., Kumar, R., Orciuolo, E., Gemignani, F., Landi, S., Goldschmidt, Hartmut, Petrini, M., Dumontet, C., Canzian, F., Rossi, A. M., and Universidade do Minho

Subjects
Science & Technology
Abstract

Multiple myeloma (MM) is a hematological neoplasm that arises from a single clone of malignant plasma cells in the bone marrow. In Europe, 4.6/100 000 males and 3.2/100 000 females every year develop MM, with a median age at diagnosis around 60 years., Polish Ministry of Science and Higher Education (Lodz, Poland) - NN40217833, Fondo de Investigaciones Sanitarias (Madrid, Spain) - PI081051, Consejería de Salud de la Junta de Andalucia (Sevilla, Spain) - P08-CVI-4116

Published
2012

49. A RANDOMIZED PHASE II STUDY (GISL - MM03 TRIAL) WITH ORAL MELPHALAN+ PREDNISONE (MP) VERSUS MELPHALAN, + PREDNISONE + THALIDOMIDE (MPT) FOR NEWLY DIAGNOSED ELDERLY PATIENTS WITH MULTIPLE MYELOMA

Author

Sacchi, Stefano, Marcheselli, Raffaella, Pozzi, Samantha, Bari, Alessia, Ciarcia, O., Masini, L., Lazzaro, A., Morabito, F., Fragasso, A., Di Renzo, N., Quarta, G., Buda, G., Musto, P., Vigliotti, M. L., Pastorini, A., and Brugiatelli, M.

Subjects
multiple myeloma elderly, multiple myeloma elderly, MPT, MPT
Published
2009

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