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11 results on '"Budech, Christopher B."'

4. Additional file 4 of Longitudinal study of MRI and functional outcome measures in facioscapulohumeral muscular dystrophy

Author

Wang, Leo H., Shaw, Dennis W. W., Faino, Anna, Budech, Christopher B., Lewis, Leann M., Statland, Jeffrey, Eichinger, Katy, Tapscott, Stephen J., Tawil, Rabi N., and Friedman, Seth D.

Abstract

Additional file 4: Table S1. Patient demographics, genotype, and functional outcome measures. Table S2. STIR-positive muscles by baseline STIR hyperintensity levels. Table S3. LMEM results, 6MWT and Go-30-Feet regressed on visit and individual muscle fat fractions. Fat fraction coefficients correspond to IQR change increases.

Published
2021
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8. Longitudinal features of stir bright signal in FSHD1

Author

Friedman, Seth D., primary, Poliachik, Sandra L., additional, Otto, Randolph K., additional, Carter, Gregory T., additional, Budech, Christopher B., additional, Bird, Thomas D., additional, Miller, Daniel G., additional, and Shaw, Dennis W.W., additional

Published
2013
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9. Longitudinal features of stir bright signal in FSHD1.

Author

Friedman, Seth D., Poliachik, Sandra L., Otto, Randolph K., Carter, Gregory T., Budech, Christopher B., Bird, Thomas D., Miller, Daniel G., and Shaw, Dennis W.W.

Abstract

ABSTRACT Introduction: Magnetic resonance imaging of muscle shows short tau-inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker. Methods: Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes. Results: In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams. Conclusions: Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2-year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored. Muscle Nerve 49: 257-260, 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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11. Longitudinal features of stir bright signal in FSHD1.

Author

Friedman, Seth D., Poliachik, Sandra L., Otto, Randolph K., Carter, Gregory T., Budech, Christopher B., Bird, Thomas D., Miller, Daniel G., and Shaw, Dennis W.W.

Abstract

ABSTRACT Introduction: Magnetic resonance imaging of muscle shows short tau-inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker. Methods: Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes. Results: In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams. Conclusions: Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2-year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored. Muscle Nerve 49: 257-260, 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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