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1. Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial

Author: Sarraj, Amrou, Abraham, Michael G, Hassan, Ameer E, Blackburn, Spiros, Kasner, Scott E, Ortega-Gutierrez, Santiago, Hussain, Muhammad Shazam, Chen, Michael, Johns, Hannah, Churilov, Leonid, Pujara, Deep K, Shaker, Faris, Maali, Laith, Cardona Portela, Pere, Herial, Nabeel A, Gibson, Daniel, Kozak, Osman, Arenillas, Juan F, Yan, Bernard, Pérez de la Ossa, Natalia, Sundararajan, Sophia, Hu, Yin C, Cordato, Dennis J, Manning, Nathan W, Hanel, Ricardo A, Aghaebrahim, Amin N, Budzik, Ronald F, Hicks, William J, Blasco, Jordi, Wu, Teddy Y, Tsai, Jenny P, Schaafsma, Joanna D, Gandhi, Chirag D, Al-Mufti, Fawaz, Sangha, Navdeep, Warach, Steven, Kleinig, Timothy J, Yogendrakumar, Vignan, Ng, Felix, Samaniego, Edgar A, Abdulrazzak, Mohammad A, Parsons, Mark W, Rahbar, Mohammad H, Nguyen, Thanh N, Fifi, Johanna T, Mendes Pereira, Vitor, Lansberg, Maarten G, Albers, Greg W, Furlan, Anthony J, Jabbour, Pascal, Sitton, Clark W, Sila, Cathy, Bambakidis, Nicholas, Davis, Stephen M, Wechsler, Lawrence, Hill, Michael D, Grotta, James C, Ribo, Marc, and Campbell, Bruce C V
Published: 2024
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2. New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial.

Author: Gupta, Rishi, Saver, Jeffrey L, Levy, Elad, Zaidat, Osama O, Yavagal, Dileep, Liebeskind, David S, Khaldi, Ahmad, Gross, Bradley, Lang, Michael, Narayanan, Sandra, Jankowitz, Brian, Snyder, Kenneth, Siddiqui, Adnan, Davies, Jason, Lin, Eugene, Hassan, Ameer, Hanel, Ricardo, Aghaebrahim, Amin, Kaushal, Ritesh, Malek, Ali, Mueller-Kronast, Nils, Starke, Robert, Bozorgchami, Hormozd, Nesbit, Gary, Horikawa, Masahiro, Priest, Ryan, Liu, Jesse, Budzik, Ronald F, Pema, Peter, Vora, Nirav, Taqi, M Asif, Samaniego, Edgar, Wang, Qingliang Tony, Nossek, Erez, Dabus, Guilherme, Linfante, Italo, Puri, Ajit, Abergel, Eitan, Starkman, Sidney, Tateshima, Satoshi, Jadhav, Ashutosh P, and TIGER Trial Investigators
Subjects: TIGER Trial Investigators, Humans, Thrombectomy, Aged, Middle Aged, Female, Male, Endovascular Procedures, Ischemic Stroke, goal, intracranial hemorrhage, laboratories, reperfusion, stent, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract: [Figure: see text].
Published: 2021

3. Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes after Acute Ischemic Stroke: An Analysis of the DAWN Trial.

Author: Nogueira, Raul G., Doheim, Mohamed F., Jadhav, Ashutosh P., Aghaebrahim, Amin, Frankel, Michael R., Jankowitz, Brian T., Budzik, Ronald F., Bonafe, Alain, Bhuva, Parita, Yavagal, Dileep R., Hanel, Ricardo A., Hassan, Ameer E., Ribo, Marc, Cognard, Christophe, Sila, Cathy A., Jenkins, Paul, Smith, Wade S., Saver, Jeffrey L., Liebeskind, David S., and Jovin, Tudor G.
Subjects: ISCHEMIC stroke, TREATMENT effectiveness, ENDOVASCULAR surgery, REPERFUSION, INTRACRANIAL hemorrhage
Abstract: Objective: We aimed to assess the impact of time to endovascular thrombectomy (EVT) on clinical outcomes in the DAWN trial, while also exploring the potential effect modification of mode of stroke onset on this relationship. Methods: The association between every 1‐h treatment delay with 90‐day functional independence (modified Rankin Scale [mRS] score 0–2), symptomatic intracranial hemorrhage, and 90‐day mortality was explored in the overall population and in three modes of onset subgroups (wake‐up vs. witnessed vs. unwitnessed). Results: Out of the 205 patients, 98 (47.8%) and 107 (52.2%) presented in the 6 to 12 hours and 12 to 24 hours time window, respectively. Considering all three modes of onset together, there was no statistically significant association between time last seen well to randomization with either functional independence or mortality at 90 days in either the endovascular thrombectomy (mRS 0–2 1‐hour delay OR 1.07; 95% CI 0.93–1.24; mRS 6 OR 0.84; 95% CI 0.65–1.03) or medical management (mRS 0–2 1‐hour delay OR 0.98; 95% CI 0.80–1.14; mRS 6 1‐hour delay OR 0.94; 95% CI 0.79–1.09) groups. Moreover, there was no significant interaction between treatment effect and time (p = 0.439 and p = 0.421 for mRS 0–2 and 6, respectively). However, within the thrombectomy group, the models that tested the association between time last seen well to successful reperfusion (modified Treatment in Cerebral Infarction ≥2b) and 90‐day functional independence showed a significant interaction with mode of presentation (p = 0.013). This appeared to be driven by a nominally positive slope for both witnessed and unwitnessed strokes versus a significantly (p = 0.018) negative slope in wake‐up patients. There was no association between treatment times and symptomatic intracranial hemorrhage. Interpretation: Mode of onset modifies the effect of time to reperfusion on thrombectomy outcomes, and should be considered when exploring different treatment paradigms in the extended window. ANN NEUROL 2024;96:356–364 [ABSTRACT FROM AUTHOR]
Published: 2024
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4. Clinical relevance of intracranial hemorrhage after thrombectomy versus medical management for large core infarct: a secondary analysis of the SELECT2 randomized trial

Author: Chen, Michael, primary, Joshi, Krishna C, additional, Kolb, Bradley, additional, Sitton, Clark W, additional, Pujara, Deep Kiritbhai, additional, Abraham, Michael G, additional, Ortega-Gutierrez, Santiago, additional, Kasner, Scott E, additional, Hussain, Shazam M, additional, Churilov, Leonid, additional, Blackburn, Spiros, additional, Sundararajan, Sophia, additional, Hu, Yin C, additional, Herial, Nabeel, additional, Arenillas, Juan F, additional, Tsai, Jenny P, additional, Budzik, Ronald F, additional, Hicks, William, additional, Kozak, Osman, additional, Yan, Bernard, additional, Cordato, Dennis, additional, Manning, Nathan W, additional, Parsons, Mark, additional, Hanel, Ricardo A, additional, Aghaebrahim, Amin, additional, Wu, Teddy, additional, Cardona Portela, Pere, additional, Gandhi, Chirag D, additional, Al-Mufti, Fawaz, additional, Perez de la Ossa, Natalia, additional, Schaafsma, Joanna, additional, Blasco, Jordi, additional, Sangha, Navdeep, additional, Warach, Steven, additional, Kleinig, Timothy J, additional, Johns, Hannah, additional, Shaker, Faris, additional, Abdulrazzak, Mohammad A, additional, Ray, Abhishek, additional, Sunshine, Jeffery, additional, Opaskar, Amanda, additional, Duncan, Kelsey R, additional, Xiong, Wei, additional, Al-Shaibi, Faisal K, additional, Samaniego, Edgar A, additional, Nguyen, Thanh N, additional, Fifi, Johanna T, additional, Tjoumakaris, Stavropoula I, additional, Jabbour, Pascal, additional, Mendes Pereira, Vitor, additional, Lansberg, Maarten G, additional, Sila, Cathy, additional, Bambakidis, Nicholas C, additional, Davis, Stephen, additional, Wechsler, Lawrence, additional, Albers, Gregory W, additional, Grotta, James C, additional, Ribo, Marc, additional, Hassan, Ameer E, additional, Campbell, Bruce, additional, Hill, Michael D, additional, and Sarraj, Amrou, additional
Published: 2024
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5. Abstract WMP92: Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes After Acute Ischemic Stroke: An Analysis of the DAWN Trial

Author: Dohiem, Mohamed, primary, Jadhav, Ashutosh, additional, Aghaebrahim, Amin, additional, Frankel, Michael, additional, Jankowitz, Brian, additional, Budzik, Ronald, additional, Bonafe, Alain, additional, Bhuva, Parita, additional, Yavagal, Dileep R, additional, Hanel, Ricardo, additional, Hassan, Ameer E, additional, Ribo, Marc, additional, Cognard, Christophe, additional, Sila, Cathy, additional, Jenkins, Paul, additional, Morgan, Patricia M, additional, Smith, Wade, additional, Saver, Jeffrey, additional, Liebeskind, David S, additional, Jovin, Tudor, additional, Haussen, Diogo C, additional, and Nogueira, Raul G, additional
Published: 2024
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6. Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomised patients in the SWIFT trial

Author: Sheth, Sunil A, Jahan, Reza, Levy, Elad I, Jovin, Tudor G, Baxter, Blaise, Nogueira, Raul G, Clark, Wayne, Budzik, Ronald, Zaidat, Osama O, and Saver, Jeffrey L
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Clinical Trials and Supportive Activities, Stroke, Neurosciences, Brain Disorders, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Aged, 80 and over, Brain Ischemia, Female, Humans, Learning Curve, Male, Middle Aged, Prospective Studies, Stents, Survival Rate, Thrombectomy, SWIFT Trialists, Angiography, Intervention, Technique, Clinical sciences
Abstract: BackgroundIn light of recent positive trial data for endovascular therapy in acute ischemic stroke (AIS), stent retriever use by practitioners without prior experience with these devices may become more common.ObjectiveTo assess the safety and efficacy of thrombectomy for AIS using Solitaire for patients treated in the roll-in period of the Solitaire With the Intention For Thrombectomy (SWIFT) trial, which represented the first clinical use of the device for these interventionalists.MethodsProspectively collected demographic, clinical, and angiographic data on patients treated in the initial roll-in and subsequent randomized phases of the SWIFT study were collected and analyzed. Key statistical analyses were validated by an independent external statistician.ResultsPatients in the roll-in period achieved equivalently high rates of reperfusion (55%) compared with those treated with the device in the randomized phase (61%). Rates of adverse events were comparable (13% vs. 9%). Rates of good neurological outcome were equivalent between the roll-in and randomized patients treated with Solitaire (63% vs. 58%). Including the roll-in patients strengthened the conclusions of the study, that reperfusion rates without symptomatic hemorrhage with Solitaire were greater than with Merci (59% vs. 24%, p
Published: 2016

7. Collateral Circulation in Thrombectomy for Stroke After 6 to 24 Hours in the DAWN Trial

Author: Liebeskind, David S., Saber, Hamidreza, Xiang, Bin, Jadhav, Ashutosh P., Jovin, Tudor G., Haussen, Diogo C., Budzik, Ronald F., Bonafe, Alain, Bhuva, Parita, Yavagal, Dileep R., Hanel, Ricardo A., Ribo, Marc, Cognard, Christophe, Sila, Cathy, Hassan, Ameer E., Smith, Wade S., Saver, Jeffrey L., and Nogueira, Raul G.
Published: 2022
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8. Carotid I's, L's and T's: collaterals shape the outcome of intracranial carotid occlusion in acute ischemic stroke

Author: Liebeskind, David S, Flint, Alexander C, Budzik, Ronald F, Xiang, Bin, Smith, Wade S, Duckwiler, Gary R, and Nogueira, Raul G
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Neurosciences, Stroke, Adult, Aged, Aged, 80 and over, Brain Ischemia, Carotid Artery, Internal, Cerebral Arterial Diseases, Cerebrovascular Circulation, Clinical Trials as Topic, Collateral Circulation, Female, Humans, Male, Mechanical Thrombolysis, Middle Aged, Outcome Assessment, Health Care, Radiography, Thrombosis, Angiography, Blood Flow, Thrombectomy, MERCI and Multi-MERCI Investigators, Clinical sciences
Abstract: BackgroundCollaterals may affect revascularization, ischemic severity, and clinical outcomes in acute stroke owing to internal carotid artery (ICA) occlusion.ObjectiveTo examine the hypothesis that morphology of occlusive thrombus and collateral flow patterns may influence the outcome of ICA occlusions after mechanical thrombectomy.MethodsPooled analyses of ICA occlusions in the MERCI and Multi-MERCI trials employed central angiography review readings to categorize lesions as I, L, or T clots and functional lesions based on collateral flow patterns. Demographic variables, procedural details, and clinical outcomes were compared across ICA lesion types.ResultsA total of 72 subjects (mean age 67 years (SD 16), 51% female, median National Institutes of Health Stroke Scale 20 (range 8-35)) were included, with 90-day modified Rankin score ≤2 in 28% and 51% mortality. Clots were categorized as an I lesion in 9/72 (12.5%), L lesion in 12/72 (16.7%), and T lesion in 51/72 (70.8%). Based on collateral flow patterns, cases were categorized as having a functional I lesion in 7/72 (9.7%), functional L in 38/72 (52.8%), and functional T in only 27/72 (37.5%). Multivariate analyses showed that a functional T lesion, with insufficient collateral flow to ipsilateral anterior cerebral arteries via the contralateral ICA, was a strong predictor of both revascularization success and subsequent clinical outcomes.ConclusionsCollateral flow patterns distinguish the nature and impact of ICA occlusions on expected revascularization and subsequent clinical outcomes in acute ischemic stroke. The nomenclature of terminal ICA occlusions introduced here (carotid I's, L's, and T's) may enhance future endovascular trials targeting such proximal occlusions.Trial registration numberNCT00318071 (http://clinicaltrials.gov). MERCI was not registered because enrollment began before July 1, 2005.
Published: 2015

9. Predictors of Functional Dependence Despite Successful Revascularization in Large-Vessel Occlusion Strokes

Author: Shi, Zhong-Song, Liebeskind, David S, Xiang, Bin, Ge, Sijian Grace, Feng, Lei, Albers, Gregory W, Budzik, Ronald, Devlin, Thomas, Gupta, Rishi, Jansen, Olav, Jovin, Tudor G, Killer-Oberpfalzer, Monika, Lutsep, Helmi L, Macho, Juan, Nogueira, Raul G, Rymer, Marilyn, Smith, Wade S, Wahlgren, Nils, and Duckwiler, Gary R
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Clinical Trials and Supportive Activities, Stroke, Clinical Research, Brain Disorders, Aged, Aged, 80 and over, Brain Infarction, Brain Ischemia, Cerebral Revascularization, Clinical Trials as Topic, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic, Predictive Value of Tests, Recovery of Function, Severity of Illness Index, Thrombectomy, Thrombolytic Therapy, stroke, Multi MERCI, TREVO, and TREVO 2 Investigators, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract: Background and purposeHigh revascularization rates in large-vessel occlusion strokes treated by mechanical thrombectomy are not always associated with good clinical outcomes. We evaluated predictors of functional dependence despite successful revascularization among patients with acute ischemic stroke treated with thrombectomy.MethodsWe analyzed the pooled data from the Multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI), Thrombectomy Revascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO), and TREVO 2 trials. Successful revascularization was defined as thrombolysis in cerebral infarction score 2b or 3. Functional dependence was defined as a score of 3 to 6 on the modified Rankin Scale at 3 months. We assessed relationship of demographic, clinical, angiographic characteristics, and hemorrhage with functional dependence despite successful revascularization.ResultsTwo hundred and twenty-eight patients with successful revascularization had clinical outcome follow-up. The rates of functional dependence with endovascular success were 48.6% for Trevo thrombectomy and 58.0% for Merci thrombectomy. Age (odds ratio, 1.04; 95% confidence interval, 1.02-1.06 per 1-year increase), National Institutes of Health Stroke Scale score (odds ratio, 1.08; 95% confidence interval, 1.02-1.15 per 1-point increase), and symptom onset to endovascular treatment time (odds ratio, 1.11; 95% confidence interval, 1.01-1.22 per 30-minute delay) were predictors of functional dependence despite successful revascularization. Symptom onset to reperfusion time beyond 5 hours was associated with functional dependence. All subjects with symptomatic intracranial hemorrhage had functional dependence.ConclusionsOne half of patients with successful mechanical thrombectomy do not have good outcomes. Age, severe neurological deficits, and delayed endovascular treatment were associated with functional dependence despite successful revascularization. Our data support efforts to minimize delays to endovascular therapy in patients with acute ischemic stroke to improve outcomes.Clinical trial registration urlhttp://www.clinicaltrials.gov. Unique identifier: NCT00318071, NCT01088672, and NCT01270867.
Published: 2014

10. Endovascular Thrombectomy Treatment Effect in Direct vs Transferred Patients With Large Ischemic Strokes: A Prespecified Analysis of the SELECT2 Trial.

Author: Sarraj, Amrou, Hill, Michael D., Hussain, M. Shazam, Abraham, Michael G., Ortega-Gutierrez, Santiago, Chen, Michael, Kasner, Scott E., Churilov, Leonid, Pujara, Deep K., Johns, Hannah, Blackburn, Spiros, Sundararajan, Sophia, Hu, Yin C., Herial, Nabeel A., Budzik, Ronald F., Hicks, William J., Arenillas, Juan F., Tsai, Jenny P., Kozak, Osman, and Cordato, Dennis J.
Published: 2024
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11. Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles.

Author: Sarraj, Amrou, Hassan, Ameer E., Abraham, Michael G., Ortega-Gutierrez, Santiago, Kasner, Scott E., Hussain, Muhammad Shazam, Chen, Michael, Churilov, Leonid, Johns, Hannah, Sitton, Clark W., Yogendrakumar, Vignan, Ng, Felix C., Pujara, Deep K., Blackburn, Spiros, Sundararajan, Sophia, Hu, Yin C., Herial, Nabeel A., Arenillas, Juan F., Tsai, Jenny P., and Budzik, Ronald F.
Subjects: ENDOVASCULAR surgery, ISCHEMIC stroke, STROKE patients, TREATMENT effect heterogeneity, DIFFUSION magnetic resonance imaging, REPERFUSION injury, LACUNAR stroke
Abstract: Key Points: Question: Does the benefit from endovascular thrombectomy for patients with large ischemic strokes caused by large vessel occlusion vary by the extent of presenting ischemic injury? Findings: In an exploratory analysis of a randomized clinical trial that included 336 participants, while functional outcomes worsened as baseline ischemic core volumes increased, endovascular thrombectomy was associated with better clinical outcomes across a wide spectrum of ischemic changes and penumbra profiles on various imaging modalities compared with medical management. Meaning: Endovascular thrombectomy, compared with medical management, improved clinical outcomes across a wide spectrum of ischemic core volumes and penumbral profiles; however, large ischemic core volume is an important prognostic factor to consider when individualizing treatment decisions. Importance: Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of ischemic injury is uncertain. Objective: To describe the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and clinical outcomes and EVT treatment effect. Design, Setting, and Participants: An exploratory analysis of the SELECT2 trial, which randomized 352 adults (18-85 years) with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery (M1 segment) and large ischemic core to EVT vs medical management (MM), across 31 global centers between October 2019 and September 2022. Intervention: EVT vs MM. Main Outcomes and Measures: Primary outcome was functional outcome—90-day mRS score (0, no symptoms, to 6, death) assessed by adjusted generalized OR (aGenOR; values >1 represent more favorable outcomes). Benefit of EVT vs MM was assessed across levels of ischemic injury defined by noncontrast CT using ASPECTS score and by the volume of brain with severely reduced blood flow on CT perfusion or restricted diffusion on MRI. Results: Among 352 patients randomized, 336 were analyzed (median age, 67 years; 139 [41.4%] female); of these, 168 (50%) were randomized to EVT, and 2 additional crossover MM patients received EVT. In an ordinal analysis of mRS at 90 days, EVT improved functional outcomes compared with MM within ASPECTS categories of 3 (aGenOR, 1.71 [95% CI, 1.04-2.81]), 4 (aGenOR, 2.01 [95% CI, 1.19-3.40]), and 5 (aGenOR, 1.85 [95% CI, 1.22-2.79]). Across strata for CT perfusion/MRI ischemic core volumes, aGenOR for EVT vs MM was 1.63 (95% CI, 1.23-2.16) for volumes ≥70 mL, 1.41 (95% CI, 0.99-2.02) for ≥100 mL, and 1.47 (95% CI, 0.84-2.56) for ≥150 mL. In the EVT group, outcomes worsened as ASPECTS decreased (aGenOR, 0.91 [95% CI, 0.82-1.00] per 1-point decrease) and as CT perfusion/MRI ischemic core volume increased (aGenOR, 0.92 [95% CI, 0.89-0.95] per 10-mL increase). No heterogeneity of EVT treatment effect was observed with or without mismatch, although few patients without mismatch were enrolled. Conclusion and Relevance: In this exploratory analysis of a randomized clinical trial of patients with extensive ischemic stroke, EVT improved clinical outcomes across a wide spectrum of infarct volumes, although enrollment of patients with minimal penumbra volume was low. In EVT-treated patients, clinical outcomes worsened as presenting ischemic injury estimates increased. Trial Registration: ClinicalTrials.gov Identifier: NCT03876457 This exploratory analysis of the SELECT2 trial assesses the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and the association of mismatch with clinical outcomes and endovascular treatment effect in adult patients with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery and large ischemic core in 31 global centers between October 2019 and September 2022. [ABSTRACT FROM AUTHOR]
Published: 2024
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12. Serial ASPECTS in the DAWN Trial: Infarct Evolution and Clinical Impact

Author: Liebeskind, David S., Saber, Hamidreza, Bhuva, Parita, Xiang, Bin, Yoo, Albert J., Jadhav, Ashutosh P., Haussen, Diogo C., Budzik, Ronald F., Bonafe, Alain, Yavagal, Dileep R., Hanel, Ricardo A., Ribo, Marc, Cognard, Christophe, Sila, Cathy, Hassan, Ameer E., Smith, Wade S., Saver, Jeffrey L., Nogueira, Raul G., and Jovin, Tudor G.
Published: 2021
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13. Early Infarct Growth Rate Correlation With Endovascular Thrombectomy Clinical Outcomes: Analysis From the SELECT Study

Author: Sarraj, Amrou, Hassan, Ameer E., Grotta, James, Blackburn, Spiros, Day, Arthur, Abraham, Michael, Sitton, Clark, Dannenbaum, Mark, Cai, Chunyan, Pujara, Deep, Hicks, William, Vora, Nirav, Budzik, Ronald, Shaker, Faris, Arora, Ashish, Riascos, Roy F., Kamal, Haris, Martin-Schild, Sheryl, Lansberg, Maarten, Gupta, Rishi, and Albers, Gregory W.
Published: 2021
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14. Thrombectomy Outcomes With General vs Nongeneral Anesthesia

Author: Sarraj, Amrou, Albers, Gregory W., Mitchell, Peter J., Hassan, Ameer E., Abraham, Michael G., Blackburn, Spiros, Sharma, Gagan, Yassi, Nawaf, Kleinig, Timothy J., Shah, Darshan G., Wu, Teddy Y., Hussain, Muhammad Shazam, Tekle, Wondwoseen G., Gutierrez, Santiago Ortega, Aghaebrahim, Amin Nima, Haussen, Diogo C., Toth, Gabor, Pujara, Deep, Budzik, Ronald F., Hicks, William, Vora, Nirav, Edgell, Randall C., Slavin, Sabreena, Lechtenberg, Colleen G., Maali, Laith, Qureshi, Abid, Rosterman, Lee, Abdulrazzak, Mohammad Ammar, AlMaghrabi, Tareq, Shaker, Faris, Mir, Osman, Arora, Ashish, Martin-Schild, Sheryl, Sitton, Clark W., Churilov, Leonid, Gupta, Rishi, Lansberg, Maarten G., Nogueira, Raul G., Grotta, James C., Donnan, Geoffrey Alan, Davis, Stephen M., and Campbell, Bruce C. V.
Subjects: Neurology (clinical), Research Article
Abstract: Background and ObjectivesThe effect of anesthesia choice on endovascular thrombectomy (EVT) outcomes is unclear. Collateral status on perfusion imaging may help identify the optimal anesthesia choice.MethodsIn a pooled patient-level analysis of EXTEND-IA, EXTEND-IA TNK, EXTEND-IA TNK part II, and SELECT, EVT functional outcomes (modified Rankin Scale score distribution) were compared between general anesthesia (GA) vs non-GA in a propensity-matched sample. Furthermore, we evaluated the association of collateral flow on perfusion imaging, assessed by hypoperfusion intensity ratio (HIR) – Tmax > 10 seconds/Tmax > 6 seconds (good collaterals – HIR < 0.4, poor collaterals – HIR ≥ 0.4) on the association between anesthesia type and EVT outcomes.ResultsOf 725 treated with EVT, 299 (41%) received GA and 426 (59%) non-GA. The baseline characteristics differed in presentation National Institutes of Health Stroke Scale score (median [interquartile range] GA: 18 [13–22], non-GA: 16 [11–20],p< 0.001) and ischemic core volume (GA: 15.0 mL [3.2–38.0] vs non-GA: 9.0 mL [0.0–31.0],p< 0.001). In addition, GA was associated with longer last known well to arterial access (203 minutes [157–267] vs 186 minutes [138–252],p= 0.002), but similar procedural time (35.5 minutes [23–59] vs 34 minutes [22–54],p= 0.51). Of 182 matched pairs using propensity scores, baseline characteristics were similar. In the propensity score–matched pairs, GA was independently associated with worse functional outcomes (adjusted common odds ratio [adj. cOR]: 0.64, 95% CI: 0.44–0.93,p= 0.021) and higher neurologic worsening (GA: 14.9% vs non-GA: 8.9%, aOR: 2.10, 95% CI: 1.02–4.33,p= 0.045). Patients with poor collaterals had worse functional outcomes with GA (adj. cOR: 0.47, 95% CI: 0.29–0.76,p= 0.002), whereas no difference was observed in those with good collaterals (adj. cOR: 0.93, 95% CI: 0.50–1.74,p= 0.82),pinteraction: 0.07. No difference was observed in infarct growth overall and in patients with good collaterals, whereas patients with poor collaterals demonstrated larger infarct growth with GA with a significant interaction between collaterals and anesthesia type on infarct growth rate (pinteraction: 0.020).DiscussionGA was associated with worse functional outcomes after EVT, particularly in patients with poor collaterals in a propensity score–matched analysis from a pooled patient-level cohort from 3 randomized trials and 1 prospective cohort study. The confounding by indication may persist despite the doubly robust nature of the analysis. These findings have implications for randomized trials of GA vs non-GA and may be of utility for clinicians when making anesthesia type choice.Classification of EvidenceThis study provides Class III evidence that use of GA is associated with worse functional outcome in patients undergoing EVT.Trial Registration InformationEXTEND-IA: ClinicalTrials.gov (NCT01492725); EXTEND-IA TNK: ClinicalTrials.gov (NCT02388061); EXTEND-IA TNK part II: ClinicalTrials.gov (NCT03340493); and SELECT: ClinicalTrials.gov (NCT02446587).
Published: 2022

15. Benefit of Endovascular Thrombectomy by Mode of Onset: Secondary Analysis of the DAWN Trial

Author: Jadhav, Ashutosh P., Aghaebrahim, Amin, Jankowitz, Brian T., Haussen, Diogo C., Budzik, Ronald F., Bonafe, Alain, Bhuva, Parita, Yavagal, Dileep R., Hanel, Ricardo A., Hassan, Ameer E., Ribo, Marc, Cognard, Christophe, Sila, Cathy A., Zhang, Yanchang, Smith, Wade S., Saver, Jeffrey L., Liebeskind, David S., Nogueira, Raul G., and Jovin, Tudor G.
Published: 2019
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16. Noncontrast Computed Tomography Alberta Stroke Program Early CT Score May Modify Intra-Arterial Treatment Effect in DAWN

Author: Bhuva, Parita, Yoo, Albert J., Jadhav, Ashutosh P., Jovin, Tudor G., Haussen, Diogo C., Bonafe, Alain, Budzik, Ronald J., Yavagal, Dileep R., Hanel, Ricardo A., Hassan, Ameer E., Ribo, Marc, Cognard, Christophe, Sila, Cathy A., Morgan, Patricia M., Zhang, Yanchang, Shields, Ryan, Smith, Wade, Saver, Jeffrey L., Liebeskind, David S., and Nogueira, Raul G.
Published: 2019
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17. Trial of Endovascular Thrombectomy for Large Ischemic Strokes

Author: Sarraj, Amrou, primary, Hassan, Ameer E., additional, Abraham, Michael G., additional, Ortega-Gutierrez, Santiago, additional, Kasner, Scott E., additional, Hussain, M. Shazam, additional, Chen, Michael, additional, Blackburn, Spiros, additional, Sitton, Clark W., additional, Churilov, Leonid, additional, Sundararajan, Sophia, additional, Hu, Yin C., additional, Herial, Nabeel A., additional, Jabbour, Pascal, additional, Gibson, Daniel, additional, Wallace, Adam N., additional, Arenillas, Juan F., additional, Tsai, Jenny P., additional, Budzik, Ronald F., additional, Hicks, William J., additional, Kozak, Osman, additional, Yan, Bernard, additional, Cordato, Dennis J., additional, Manning, Nathan W., additional, Parsons, Mark W., additional, Hanel, Ricardo A., additional, Aghaebrahim, Amin N., additional, Wu, Teddy Y., additional, Cardona-Portela, Pere, additional, Pérez de la Ossa, Natalia, additional, Schaafsma, Joanna D., additional, Blasco, Jordi, additional, Sangha, Navdeep, additional, Warach, Steven, additional, Gandhi, Chirag D., additional, Kleinig, Timothy J., additional, Sahlein, Daniel, additional, Elijovich, Lucas, additional, Tekle, Wondwossen, additional, Samaniego, Edgar A., additional, Maali, Laith, additional, Abdulrazzak, M. Ammar, additional, Psychogios, Marios N., additional, Shuaib, Ashfaq, additional, Pujara, Deep K., additional, Shaker, Faris, additional, Johns, Hannah, additional, Sharma, Gagan, additional, Yogendrakumar, Vignan, additional, Ng, Felix C., additional, Rahbar, Mohammad H., additional, Cai, Chunyan, additional, Lavori, Philip, additional, Hamilton, Scott, additional, Nguyen, Thanh, additional, Fifi, Johanna T., additional, Davis, Stephen, additional, Wechsler, Lawrence, additional, Pereira, Vitor M., additional, Lansberg, Maarten G., additional, Hill, Michael D., additional, Grotta, James C., additional, Ribo, Marc, additional, Campbell, Bruce C., additional, and Albers, Gregory W., additional
Published: 2023
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18. Abstract Number ‐ 7: Final Angiographic, Clinical and Thrombus Composition Results of 1000 Patients in the EXCELLENT Registry

Author: Nogueira, Raul G, primary, Andersson, Tommy, additional, Yoo, Albert J, additional, Hanel, Ricardo A, additional, Zaidat, Osama O, additional, Hacke, Werner, additional, Jovin, Tudor, additional, Fiehler, Jens, additional, De Meyer, Simon F, additional, Brinjikji, Waleed, additional, Doyle, Karen, additional, Liebeskind, David S, additional, Haussen, Diogo, additional, Inoa, Violiza, additional, Humphries, William, additional, Woodward, Keith B, additional, Jabbour, Pascal M, additional, Francois, Olivier, additional, Bozorgchami, Hormozd, additional, Levy, Elad I, additional, Boor, Stephan, additional, Cohen, Jose, additional, Dashti, Shervin R, additional, Taqi, Muhammad A, additional, Budzik, Ronald F, additional, Schirmer, Clemens M, additional, Hussain, Shazam, additional, Estrade, Laurent, additional, De Leacy, Reade A, additional, Puri, Ajit S, additional, Chitale, Rohan V, additional, Brekenfeld, Caspar, additional, and Siddiqui, Adnan H, additional
Published: 2023
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19. Abstract WP7: Mstu Validation Of A Pre-reperfusion Map For Better Thrombectomy Outcomes

Author: Hake, Joshua, primary, Willis, Corbin, additional, Killedar, Amogh, additional, Shah, Sarthak, additional, Fuchs, Vadeem, additional, Hicks, William J, additional, Katz, Brian S, additional, Rai, Vivek, additional, Jennings, Nate, additional, Hill, Michelle, additional, Loochtan, Aaron, additional, Budzik, Ronald, additional, Pema, Peter J, additional, Alhajeri, Abdulnasser, additional, and Vora, Nirav, additional
Published: 2023
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20. Abstract 28: First Pass Outcomes And Associated Clot Characteristics: Secondary Analysis Of The Excellent Registry

Author: Andersson, Tommy, primary, Nogueira, Raul G, additional, Yoo, Albert J, additional, Hanel, Ricardo, additional, Zaidat, Osama O, additional, Hacke, Werner, additional, Jovin, Tudor, additional, Fiehler, Jens, additional, De Meyer, Simon F, additional, Brinjikji, Waleed, additional, Doyle, Karen, additional, Liebeskind, David S, additional, Haussen, Diogo C, additional, Inoa, Violiza, additional, Humphries, William E, additional, Woodward, Keith B, additional, Jabbour, Pascal M, additional, Francois, Olivier, additional, Bozorgchami, Hormozd, additional, Levy, Elad I, additional, Boor, Stephan, additional, Cohen, Jose, additional, Dashti, Shervin R, additional, Taqi, Muhammad A, additional, Budzik, Ronald F, additional, Schirmer, Clemens M, additional, Hussain, M. Shazam, additional, Estrade, Laurent, additional, De Leacy, Reade A, additional, Puri, Ajit S, additional, Chitale, Rohan V, additional, Brekenfeld, Caspar, additional, and Siddiqui, Adnan H, additional
Published: 2023
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21. Abstract 24: Primary Results Of The Preset For Occlusive Stroke Treatment (prost) Randomized Clinical Trial

Author: Nogueira, Raul G, primary, Hanel, Ricardo, additional, Klisch, Joachim, additional, Moehlenbruch, Markus, additional, Bozorgchami, Hormozd, additional, Samaniego, Edgar A, additional, Liebeskind, David S, additional, Lobsien, Donald, additional, Pielenz, Daniel, additional, Sauvageau, Eric, additional, Aghaebrahim, Amin N, additional, Clark, Wayne M, additional, Priest, Ryan, additional, Ortega-Gutierrez, Santiago, additional, Lopes, Demetrius, additional, Billingsley, Joshua, additional, Haussen, Diogo C, additional, Al-Bayati, Alhamza R, additional, Siddiqui, Adnan H, additional, Chen, Michael, additional, Schramm, Peter, additional, Narayanan, Sandra, additional, Roth, Christian, additional, Boeckh-Behrens, Tobias, additional, Hassan, Ameer E, additional, Fifi, Johanna T, additional, Budzik, Ronald, additional, Tarpley, Jason W, additional, Starke, Robert, additional, and Raz, Eytan, additional
Published: 2023
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22. Outcome in Direct Versus Transfer Patients in the DAWN Controlled Trial

Author: Aghaebrahim, Amin, Jadhav, Ashutosh P., Hanel, Ricardo, Sauvageau, Eric, Granja, Manuel F., Zhang, Yanchang, Haussen, Diogo C., Budzik, Ronald F., Bonafe, Alain, Bhuva, Parita, Ribo, Marc, Cognard, Christophe, Sila, Cathy, Yavagal, Dileep, Hassan, Ameer E., Smith, Wade S., Saver, Jeffrey, Liebeskind, David S., Nogueira, Raul G., and Jovin, Tudor G.
Published: 2019
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23. A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow–Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke)

Author: Savitz, Sean I., Yavagal, Dileep, Rappard, George, Likosky, William, Rutledge, Neal, Graffagnino, Carmelo, Alderazi, Yazan, Elder, Jennifer A., Chen, Peng R., Budzik, Ronald F., Jr, Tarrel, Ronald, Huang, David Y., and Hinson, James M., Jr
Published: 2019
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24. Delayed Functional Independence After Neurothrombectomy (DEFIANT) score: analysis of the Trevo Retriever Registry.

Author: Jadhav, Ashutosh P., Desai, Shashvat M., Gupta, Rishi, Baxter, Blaise W., Bartolini, Bruno, Krajina, Antonin, English, Joey D., Nogueira, Raul G., Liebeskind, David S., Veznedaroglu, Erol, and Budzik, Ronald F.
Subjects: STROKE, FUNCTIONAL status, AGE distribution, ACQUISITION of data, RESEARCH funding, ENDOVASCULAR surgery, HEMORRHAGE
Abstract: Background Chronological heterogeneity in neurological improvement after endovascular thrombectomy (EVT) for large vessel occlusion (LVO) stroke is commonly observed in clinical practice. Understanding the temporal progression of functional independence after EVT, especially delayed functional independence in patients who do not improve early, is essential for prognostication and rehabilitation. We aim to determine the incidence of early functional independence (EFI) and delayed functional independence (DFI), identify associated predictors after EVT, and develop the Delayed Functional Independence After Neurothrombectomy (DEFIANT) score. Methods Demographic, clinical, radiological, treatment, and procedural information were analyzed from the Trevo Registry (patients undergoing EVT due to anterior LVO using the Trevo stent retriever). Incidence and predictors of EFI (modified Rankin Scale (mRS) score 0-2 at discharge) and DFI (mRS score 0-2 at 90 days in non-EFI patients) were analyzed. Results A total of 1623 patients met study criteria. EFI was observed in 45% (730) of patients. Among surviving non-EFI patients (884), DFI was observed in 35% (308). Younger age (p=0.003), lower discharge National Institutes of Health Stroke Scale (NIHSS) score (p<0.0001), and absence of any hemorrhage (p=0.021) were independent predictors of DFI. After age 60, the probability of DFI declines significantly with 5 year age increments (approximately 7% decline for every 5 years; p(DFI)= 1.3559-0.0699, p for slope=0.001). The DEFIANT score is available online (https://bit.ly/ 3KZRVq5). Conclusion Approximately 45% of patients experience EFI. About one-third of non-early improvers experience DFI. Younger age, lower discharge NIHSS score, and absence of any hemorrhage were independent predictors of DFI among non-early improvers. [ABSTRACT FROM AUTHOR]
Published: 2023
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25. A Decade of Improvement in Door‐to‐Puncture Times for Mechanical Thrombectomy But Ongoing Stagnation in Prehospital Care

Author: Sun, Chung‐Huan, primary, Zaidat, Osama O., additional, Castonguay, Alicia C., additional, Veznedaroglu, Erol, additional, Budzik, Ronald F., additional, English, Joey, additional, Baxter, Blaise, additional, Nogueira, Raul G., additional, Krajina, Antonín, additional, Bartolini, Bruno, additional, Liebeskind, David S., additional, Smith, Wade, additional, Koenig, Matt, additional, Jenkins, Paul, additional, and Gupta, Rishi, additional
Published: 2023
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26. Delayed Functional Independence After Neurothrombectomy (DEFIANT) score: analysis of the Trevo Retriever Registry

Author: Jadhav, Ashutosh P, primary, Desai, Shashvat M, additional, Gupta, Rishi, additional, Baxter, Blaise W, additional, Bartolini, Bruno, additional, Krajina, Antonin, additional, English, Joey D, additional, Nogueira, Raul G, additional, Liebeskind, David S, additional, Veznedaroglu, Erol, additional, and Budzik, Ronald F, additional
Published: 2022
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27. Abstract P219: Effect Of Hypertension On Clinical Recovery After Stroke Thrombectomy

Author: Killedar, Amogh, primary, Hill, Michelle, additional, Pema, Peter, additional, Budzik, Ronald, additional, Alhajeri, Abdulnasser, additional, Koss, Adam, additional, Dedhia, Nikita, additional, Loochtan, Aaron, additional, Rai, Vivek, additional, Katz, Brian, additional, Hicks, William, additional, Raetzke, Brad, additional, and Vora, Nirav, additional
Published: 2022
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28. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Author: Nogueira, Raul G., Jadhav, Ashutosh P., Haussen, Diogo C., Bonafe, Alain, Budzik, Ronald F., Bhuva, Parita, Yavagal, Dileep R., Ribo, Marc, Cognard, Christophe, Hanel, Ricardo A., Sila, Cathy A., Hassan, Ameer E., Millan, Monica, Levy, Elad I., Mitchell, Peter, Chen, Michael, English, Joey D., Shah, Qaisar A., Silver, Frank L., Pereira, Vitor M., Mehta, Brijesh P., Baxter, Blaise W., Abraham, Michael G., Cardona, Pedro, Veznedaroglu, Erol, Hellinger, Frank R., Feng, Lei, Kirmani, Jawad F., Lopes, Demetrius K., Jankowitz, Brian T., Frankel, Michael R., Costalat, Vincent, Vora, Nirav A., Yoo, Albert J., Malik, Amer M., Furlan, Anthony J., Rubiera, Marta, Aghaebrahim, Amin, Olivot, Jean-Marc, Tekle, Wondwossen G., Shields, Ryan, Graves, Todd, Lewis, Roger J., Smith, Wade S., Liebeskind, David S., Saver, Jeffrey L., and Jovin, Tudor G.
Published: 2018
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29. Transcatheter Therapy for Tumors of the Spine

Author: Pema, Peter J., Budzik, Ronald F., and McGraw, J. Kevin, editor
Published: 2004
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30. Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient‐Level Analysis of EXTEND‐IA Trials and SELECT Prospective Cohort.

Author: Sarraj, Amrou, Pujara, Deep K., Churilov, Leonid, Sitton, Clark W., Ng, Felix, Hassan, Ameer E., Abraham, Michael G., Blackburn, Spiros L., Sharma, Gagan, Yassi, Nawaf, Kleinig, Timothy, Shah, Darshan, Wu, Teddy Y., Tekle, Wondwossen G., Budzik, Ronald F., Hicks, William J., Vora, Nirav, Edgell, Randall C., Haussen, Diogo, and Ortega‐Gutierrez, Santiago
Subjects: CEREBRAL edema, CEREBRAL infarction, REPERFUSION, CEREBRAL ischemia, ISCHEMIC stroke
Abstract: Objective: Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both infarct growth and edema are plausible mediators of clinical benefit with reperfusion. We aimed to quantify these mediators and their interrelationship. Methods: In a pooled, patient‐level analysis of the EXTEND‐IA trials and SELECT study, we used a mediation analysis framework to quantify infarct growth and cerebral edema (midline shift) mediation effect on successful reperfusion (modified Treatment in Cerebral Ischemia ≥ 2b) association with functional outcome (modified Rankin Scale distribution). Furthermore, we evaluated an additional pathway to the original hypothesis, where infarct growth mediated successful reperfusion effect on midline shift. Results: A total 542 of 665 (81.5%) eligible patients achieved successful reperfusion. Baseline clinical and imaging characteristics were largely similar between those achieving successful versus unsuccessful reperfusion. Median infarct growth was 12.3ml (interquartile range [IQR] = 1.8–48.4), and median midline shift was 0mm (IQR = 0–2.2). Of 249 (37%) demonstrating a midline shift of ≥1mm, median shift was 2.75mm (IQR = 1.89–4.21). Successful reperfusion was associated with reductions in both predefined mediators, infarct growth (β = −1.19, 95% confidence interval [CI] = −1.51 to −0.88, p < 0.001) and midline shift (adjusted odds ratio = 0.36, 95% CI = 0.23–0.57, p < 0.001). Successful reperfusion association with improved functional outcome (adjusted common odds ratio [acOR] = 2.68, 95% CI = 1.86–3.88, p < 0.001) became insignificant (acOR = 1.39, 95% CI = 0.95–2.04, p = 0.094) when infarct growth and midline shift were added to the regression model. Infarct growth and midline shift explained 45% and 34% of successful reperfusion effect, respectively. Analysis considering an alternative hypothesis demonstrated consistent results. Interpretation: In this mediation analysis from a pooled, patient‐level cohort, a significant proportion (~80%) of successful reperfusion effect on functional outcome was mediated through reduction in infarct growth and cerebral edema. Further studies are required to confirm our findings, detect additional mediators to explain successful reperfusion residual effect, and identify novel therapeutic targets to further enhance reperfusion benefits. ANN NEUROL 2023;93:793–804 [ABSTRACT FROM AUTHOR]
Published: 2023
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31. Abstract 42: The Effect Of Anesthesia On Thrombectomy Outcomes Is Modified By Collateral Flow: Pooled Patient Level Analysis From EXTEND-IA, EXTEND-IA TNK Part I And II, And SELECT

Author: Sarraj, Amrou, primary, Albers, Gregory, additional, Hassan, Ameer, additional, Abraham, Michael G, additional, Blackburn, Spiros, additional, Hussain, Muhammad, additional, Tekle, Wondwossen, additional, Ortega-Gutierrez, Santiago, additional, Aghaebrahim, Amin N, additional, Haussen, Diogo C, additional, Toth, Gabor, additional, Budzik, Ronald, additional, Pujara, Deep K, additional, Hicks, William J, additional, Vora, Nirav, additional, Edgell, Randall C, additional, Slavin, Sabreena, additional, Lechtenberg, Colleen G, additional, Maali, Laith N, additional, Qureshi, Abid Y, additional, Rosterman, Lee, additional, Aertker, Benjamin, additional, Abdulrazzak, Mohammad A, additional, Mir, Osman, additional, Parsha, Kaushik N, additional, Reddy, Sujan S, additional, Alenzi, Bader, additional, Cai, Chunyan, additional, Almaghrabi, Tareq S, additional, Shaker, Faris, additional, Kamal, Haris, additional, Arora, Ashish, additional, Yassi, Nawaf, additional, Sharma, Gagan J, additional, Kleinig, Timothy J, additional, Shah, Darshan, additional, Wu, Teddy Y, additional, Martin-schild, Sheryl B, additional, Day, Arthur L, additional, sitton, clark W, additional, Mitchell, Peter J, additional, Gupta, Rishi, additional, Lansberg, Maarten G, additional, Nogueira, Raul G, additional, Donnan, Geoffrey A, additional, Davis, Stephen, additional, Grotta, James C, additional, and Campbell, Bruce C, additional
Published: 2022
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32. Abstract 1122‐000176: Incidence and Predictors of Delayed Functional Independence in the TREVO Retriever Registry

Author: Desai, Shashvat M, primary, Jadhav, Ashutosh P, additional, Gupta, Rishi, additional, Baxter, Blaise W, additional, Bartolini, Bruno, additional, Krajina, Antonin, additional, English, Joey, additional, Nogueira, Raul G, additional, Liebeskind, David S, additional, Veznedaroglu, Erol, additional, and Budzik, Ronald F, additional
Published: 2021
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33. Abstract 1122‐000075: Optimization of Transport Protocols to Increase the Odds of Thrombectomy

Author: Killedar, Amogh, primary, Hill, Michelle, additional, Pema, Peter, additional, Budzik, Ronald, additional, Alhajeri, Abdulnasser, additional, Koss, Adam, additional, Dedhia, Nikita, additional, Loochtan, Aaron, additional, Rai, Vivek, additional, Katz, Brian, additional, Hicks, William, additional, Vora, Nirav, additional, and Raetzke, Brad, additional
Published: 2021
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34. Thrombectomy Outcomes With General vs Nongeneral Anesthesia: A Pooled Patient-Level Analysis From the EXTEND-IA Trials and SELECT Study.

Author: Sarraj, Amrou, Albers, Gregory W., Mitchell, Peter J., Hassan, Ameer E., Abraham, Michael G., Blackburn, Spiros, Sharma, Gagan, Yassi, Nawaf, Kleinig, Timothy J., Shah, Darshan G., Wu, Teddy Y., Hussain, Muhammad Shazam, Tekle, Wondwoseen G., Gutierrez, Santiago Ortega, Aghaebrahim, Amin Nima, Haussen, Diogo C., Toth, Gabor, Pujara, Deep, Budzik, Ronald F., and Hicks, William
Published: 2023
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35. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author: Hill, Michael D, primary, Goyal, Mayank, additional, Menon, Bijoy K, additional, Nogueira, Raul G, additional, McTaggart, Ryan A, additional, Demchuk, Andrew M, additional, Poppe, Alexandre Y, additional, Buck, Brian H, additional, Field, Thalia S, additional, Dowlatshahi, Dar, additional, van Adel, Brian A, additional, Swartz, Richard H, additional, Shah, Ruchir A, additional, Sauvageau, Eric, additional, Zerna, Charlotte, additional, Ospel, Johanna M, additional, Joshi, Manish, additional, Almekhlafi, Mohammed A, additional, Ryckborst, Karla J, additional, Lowerison, Mark W, additional, Heard, Kathy, additional, Garman, David, additional, Haussen, Diogo, additional, Cutting, Shawna M, additional, Coutts, Shelagh B, additional, Roy, Daniel, additional, Rempel, Jeremy L, additional, Rohr, Axel CR, additional, Iancu, Daniela, additional, Sahlas, Demetrios J, additional, Yu, Amy Y X, additional, Devlin, Thomas G, additional, Hanel, Ricardo A, additional, Puetz, Volker, additional, Silver, Frank L, additional, Campbell, Bruce C V, additional, Chapot, René, additional, Teitelbaum, Jeanne, additional, Mandzia, Jennifer L, additional, Kleinig, Timothy J, additional, Turkel-Parrella, David, additional, Heck, Donald, additional, Kelly, Michael E, additional, Bharatha, Aditya, additional, Bang, Oh Young, additional, Jadhav, Ashutosh, additional, Gupta, Rishi, additional, Frei, Donald F, additional, Tarpley, Jason W, additional, McDougall, Cameron G, additional, Holmin, Staffan, additional, Rha, Joung-Ho, additional, Puri, Ajit S, additional, Camden, Marie-Christine, additional, Thomalla, Götz, additional, Choe, Hana, additional, Phillips, Stephen J, additional, Schindler, Joseph L, additional, Thornton, John, additional, Nagel, Simon, additional, Heo, Ji Hoe, additional, Sohn, Sung-Il, additional, Psychogios, Marios-Nikos, additional, Budzik, Ronald F, additional, Starkman, Sidney, additional, Martin, Coleman O, additional, Burns, Paul A, additional, Murphy, Seán, additional, Lopez, George A, additional, English, Joey, additional, Tymianski, Michael, additional, Demchuk, Andrew, additional, Barber, Philip, additional, Smith, Eric, additional, Bal, Simerpreet, additional, Subramaniam, Suresh, additional, Peters, Steven, additional, Couillard, Phillippe, additional, Klein, Gary, additional, Stys, Peter, additional, Menon, Bijoy, additional, Coutts, Shelagh, additional, Almekhlafi, Mohammed, additional, Hill, Michael, additional, Wong, John, additional, Mitha, Alim, additional, Eesa, Muneer, additional, Morrish, William, additional, Alqatani, Saad, additional, Kashani, Nima, additional, Ospel, Johanna, additional, Venkatesan, Prasanna, additional, Teleg, Erika, additional, Sitaram, Amith, additional, Graham, Brett, additional, Van Gaal, Stephen, additional, Moussaddy, Aimen, additional, Chakraborty, Debabrata, additional, Maraj, Nicholas, additional, Loockey, Andrew, additional, Chen, Shuo, additional, Singh, Ravinder, additional, Alsultan, Abdulaziz, additional, Asuncion, Ria, additional, Tse, Dominic, additional, Doshi, Darshan, additional, Volny, Ondrej, additional, Ojha, Piyush, additional, Wadhwa, Ankur, additional, Marko, Martha, additional, Singh, Nishita, additional, Wasyliw, Sanchea, additional, Ryckborst, Karla, additional, Kenney, Carol, additional, Save, Supriya, additional, Jambula, Anitha, additional, Newcommon, Nancy, additional, Hull, Gavin, additional, Blackstock, Darcy, additional, Kiszczak, Sharon, additional, Zimmel, Leslie, additional, Wright, Michelle, additional, Jahraus, Cari, additional, Andersen, Linda, additional, Bohn, Shelly, additional, Paul, Joseph, additional, Zhang, Oiao, additional, Doram, Craig, additional, Lowerison, Mark, additional, Hanley, Andrea, additional, Campbell, Lori, additional, Ure, Ashley, additional, Taylor, Francis, additional, Hul, Dominic, additional, Wiebe, Samuel, additional, Saluzzi, Marina, additional, Blenkin, Nicole, additional, Frayne, Richard, additional, Buck, Brian, additional, Butcher, Kenneth, additional, Shuaib, Ashfaq, additional, Jeerakathil, Tom, additional, Jickling, Glen, additional, Emery, Derek, additional, Rempel, Jeremy, additional, Owen, Richard, additional, Ashforth, Robert, additional, Yeo, Tom, additional, Kotylak, Trevor, additional, O'Kelly, Cian, additional, Chow, Michael, additional, Siddiqui, Muzaffer, additional, Saqqur, Maher, additional, D'Souza, Atlantic, additional, Lloret, Mar, additional, Butt, Asif, additional, Nomani, Ali, additional, Kalashyan, Hayrapet, additional, Thirunavukkarasu, Sibi, additional, Jabs, Juline, additional, Fairall, Paige, additional, Piquette, Lori, additional, Phillips, Stephen, additional, Green, A. Laine, additional, Gubitz, Gordon, additional, Heidenreich, Jens, additional, Huynh, Thien, additional, Shankar, Jai, additional, Maloney, William, additional, Vandorpe, Robert, additional, Schmidt, Matthias, additional, Pickett, Gwynedd, additional, Weeks, Adrienne, additional, Jarrett, Judith, additional, MacDonald, Debbie, additional, Arsenault, Joanna, additional, Kinnear, Ruth, additional, Mandzia, Jennifer, additional, Mayich, Michael, additional, Boulton, Melfort, additional, Bullrich, Maria, additional, Fridman, Sebastian, additional, Kiwan, Ruba, additional, Lee, Donald, additional, Lownie, Stephen, additional, Khaw, Alexander, additional, Pandey, Sachin, additional, Sharma, Manas, additional, Sposato, Luciano, additional, Wade, Kevin, additional, Beauchamp, Beth, additional, Lambourn, Lindsay, additional, Amato-Marziali, Belinda, additional, Poppe, Alexandre, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Gioia, Laura, additional, Jacquin, Grégory, additional, Odier, Céline, additional, Stapf, Christian, additional, Raymond, Jean, additional, Weill, Alain, additional, Lapierre, Marlène, additional, Jadil, Nadia, additional, Jolteus, Judlène, additional, Angle, Mark, additional, Hannouche, Mathew, additional, Badawy, Mohamed, additional, Letourneau, Justin, additional, Cortes, Maria, additional, Linnell, Grant, additional, Tampieri, Donateela, additional, Vieira, Lucy, additional, Legault, Catherine, additional, Durcan, Liam, additional, Moore, Angela, additional, Cole, Erin, additional, Magnussen, Claire, additional, Salmon, Kristiana, additional, Khalil, Salma, additional, Desloges, Isabelle, additional, Waxman, Lindsay, additional, Abdon, Wynne, additional, Lai, Sonia, additional, Shamy, Michel, additional, Stotts, Grant, additional, Blacquiere, Dylan, additional, Lesiuk, Howard, additional, Quateen, Aiman, additional, Drake, Brian, additional, Dewar, Brian, additional, Daham, Zeinab, additional, Kelly, Michael, additional, Hunter, Gary, additional, Peeling, Lissa, additional, Whelan, Ruth, additional, Garner, Aaron, additional, Urroz, Lilian, additional, Maley, Sharleen, additional, Silver, Frank, additional, Casaubon, Leanne, additional, Pikula, Aleksandra, additional, Del Campo, Martin, additional, Schaafsma, Joanna, additional, Jaigobin, Cheryl, additional, Krings, Timo, additional, Pereira, Vitor, additional, Agid, Ronit, additional, Farb, Richard, additional, Kalman, Libby, additional, Cayley, Anne, additional, Williams, Janice, additional, Stewart, Tim, additional, Misquitta, Karen, additional, Selchen, Daniel, additional, Marotta, Thomas, additional, Sarma, Dipanka, additional, Montanera, Walter, additional, Spears, Juluan, additional, Saposnik, Gustavo, additional, Kostyrko, Pawel, additional, Li, Yangmei, additional, Parra-Farina, Carmen, additional, Bengzon Diestro, Jose Danilo, additional, Verreault, Steve, additional, Mackey, Ariane, additional, Audet, Marie-Eve, additional, Milot, Geneviève, additional, Lavoie, Pascale, additional, Gariépy, Jean-Luc, additional, Collard, Karine, additional, Haché, Annette, additional, Van Adel, Brian, additional, Sahlas, Demetrios, additional, Alshanbari, Ahmed, additional, Baldwin, Josephine, additional, Catanese, Luciana, additional, Chen, Bing, additional, De Sa Boasquevisque, Danielle, additional, Deshmukh, Aviraj, additional, Knapman, Jordan, additional, Lamers, Shana, additional, Larrazabal, Ramiro, additional, MacMillan, Susan, additional, Mai, Lauren, additional, Mattia, Alicia, additional, Nayar, Sumiti, additional, Ng, Kuan, additional, Oczkowski, Wieslaw, additional, Perera, Kanjana, additional, Shawawrah, Mays, additional, Shoamanesh, Ashkan, additional, Sobhi, Gita, additional, Syed, Nabeel, additional, Taher, Noran, additional, Vandervelde, Cheyanne, additional, Wang Pharm, Di, additional, Field, Thalia, additional, Teal, Philip, additional, Benavente, Oscar, additional, Wilson, Laura, additional, Mann, Sharanpal, additional, Yip, Samuel, additional, Murphy, Colleen, additional, Heran, Manraj, additional, Rohr, Axel, additional, Settecase, Fabio, additional, Redekop, Gary, additional, Haw, Charles, additional, Maclean, Genoveva, additional, Murray, Karina, additional, Chiu, Rosalin, additional, Flexman, Alana, additional, Strecha, Eilidh, additional, Gayton, Yolanda, additional, Yip, Judy, additional, Swartz, Richard, additional, Boulos, Mark, additional, Gladstone, David, additional, Yu, Amy, additional, Hopyan, Julia, additional, Khosravani, Houman, additional, Manosalva Alzate, Herbert, additional, Southwell, Alisia, additional, Kamra, Maneesha, additional, Lopes, Kaitlyn, additional, Kapoor, Arunima, additional, da Costa, Leodante, additional, Yang, Victor, additional, Dyer, Erin, additional, Shah, Ruchir, additional, Knowles, Brenda, additional, Nichols, Jennifer, additional, Patterson, Jennifer, additional, Cope, Krista, additional, Dickerson, Lee, additional, Barton, Katrina, additional, Gray, Kimberly, additional, Massengale, Ticey, additional, Miller, Melanie, additional, Simpson, Cindy, additional, Walker, Sabrina, additional, Tennyson-Yemm, Chlin, additional, Devlin, Thomas, additional, Frei, Donald, additional, Bellon, Richard, additional, Atchie, Benjamin, additional, Kaminsky, Ian, additional, Wilson, Duandelyn, additional, Schraeder, Nicolle, additional, Arias, Eric, additional, Kodis, Lisa, additional, Talley, Mark, additional, Edinger, Alex, additional, Talley, Tiffany, additional, Dempsey, Ita, additional, Williams, Laurie, additional, Williams, Scott, additional, Kupniewski, Sonny, additional, Fasbinder, Brad, additional, Snead, Joanna, additional, Mackenzie, Larami, additional, Weisman, Davi, additional, Kozak, Osman, additional, Shah, Qaisar, additional, Gzesh, Dan, additional, Kulandaivel, Kandan, additional, Khoury, John, additional, Klein, Brad, additional, Bussinger, Patricia, additional, Griffin, Lisa, additional, dePalmo, Ashley, additional, Oliva, Cynthia, additional, Jovin, Tudor, additional, Kenmuir, Cynthia, additional, Jankowitz, Brian, additional, Gross, Bradley, additional, Rocha, Marcelo, additional, Starr, Matthew, additional, Brown, Merritt, additional, Hawkes, Christine, additional, Shah, Kavit, additional, Tememe, Danoushka, additional, Walker, Gregory, additional, Patel, Pratit, additional, Klein, Bradley, additional, Ziayee, Habibullah, additional, Limaye, Kaustubh, additional, Baxendell, Lisa, additional, Gilchrist, Vicki, additional, Feineigle, Patricia, additional, Toseki Haibach, Kelsea, additional, Van Every, Cathy, additional, Desai, Shashyat, additional, Zulfiqar, Maryam, additional, Gibson, Linda, additional, Barrett, Sean, additional, Arcot, Karthikeyan, additional, DiCrescento, Steven, additional, Farkas, Jeffrey, additional, Filipowski, Gregory, additional, Frontera, Jennifer, additional, Joset, Danielle, additional, Liff, Jeremy, additional, Scher, Erica, additional, McDougall, Cameron, additional, Kelly, Cheryl, additional, Patel, Akshal, additional, Monteith, Stephen, additional, Atchaneeyasakul, Kunakorn, additional, Burgos, Adrian, additional, Chua, Janice Anne, additional, Gaines, Nathan, additional, Grunberg, Ileana, additional, Guzy, Judy, additional, Liu, Zuolu, additional, Maluste, Neil, additional, Ramirez, Lucas, additional, Sharma, Latisha, additional, Brown, Morry, additional, McDonald, Colin, additional, Calderon, Mateo, additional, Hargis, Mitch, additional, Roels, Christina, additional, Emmady, Prabhu, additional, Alvi, Talat, additional, McTaggart, Ryan, additional, Jayaraman, Mahesh, additional, Cutting, Shawna, additional, Smith, Wendy, additional, Foley, Susan, additional, Paolucci, Gino, additional, Has, Richard, additional, Quinn, Katie, additional, Fuller, Lindsey, additional, Brierley, Rebecca, additional, Watkins, Christina, additional, Demir, Nicole, additional, Lopez, George, additional, Vargas, Alejandro, additional, Osteraas, Nicholas, additional, Holtz, Becky, additional, Hanel, Ricardo, additional, Aghaebrahim, Amin, additional, Chmayssani, Mohamad, additional, Naval, Neeraj, additional, Day, Jason, additional, Dellorso, Scott, additional, Ludwig, Benjamin, additional, Schemmel, Derek, additional, Ebreo, Nancy, additional, Bell, Karen, additional, Lewis, Lanai, additional, Delucia, Marjorie, additional, Nogueira, Raul, additional, Frankel, Michael, additional, Bhatt, Nirav, additional, Bianchi, Nicolas, additional, Anderson, Aaron, additional, Belagaje, Samir, additional, Liberato, Bernardo, additional, Rangaraju, Srikant, additional, Al-Bayati, Alhamza, additional, Grossberg, Jonathan, additional, Craft, Leah, additional, Schindler, Kiva, additional, Schaad, Erin, additional, Schultz, Meagan, additional, Southerly, Lorretta, additional, Doppelheuer, Shannon, additional, Charlton, Jacquelyn, additional, Faggard, Jason, additional, Barbret, Zuzana, additional, DukSoo Han, Ethan, additional, Walters, Robin, additional, Dolia, Jaydevsinh, additional, El-Jamal, Sleiman, additional, Eby, Brendan, additional, Saleem, Yasir, additional, Pearl, Harrison, additional, Patel, Kishan, additional, Rahman, Haseeb, additional, Butt, Reema, additional, English, Stephen, additional, Puri, Ajit, additional, Howk, Mary, additional, Singh, Jasmeet, additional, Massari, Francesco, additional, DeMacedo Rodrigues, Katyucia, additional, Kuhn, Anna, additional, Barazangi, Nobl, additional, Telischak, Nick, additional, Kim, Warren, additional, Ross, Josh, additional, DeVole, Nata, additional, Redford, Jessica, additional, Ferreira, Milena, additional, Ponting, Katie, additional, Shen, Helen, additional, Bedenk, Ann, additional, Patel, Susila, additional, Fernandess, Julia, additional, Ke, Michael, additional, Spokoyny, Ilanit, additional, Gao, Billy, additional, Tong, David, additional, Chen, Charlene, additional, Wong, Christine, additional, Choe, Jessica, additional, Martin, Coleman, additional, Summers, Debbie, additional, Boutwell, Christine, additional, Olds, Karin, additional, Crandall, Suzanne, additional, Eatman, John, additional, Akhtar, Naveed, additional, Holloway, William, additional, Halpin, Jared, additional, Donegan, Brett, additional, Schindler, Joseph, additional, Hwang, David, additional, Gilmore, Emily, additional, Petersen, Nils, additional, Sheth, Kevin, additional, Brown, Stacy, additional, Beekman, Rachel, additional, George, Benjamin, additional, Kaddouh, Firas, additional, Falcone, Guido, additional, Wira, Charles, additional, Matouk, Charles, additional, Loomis, Caitlin, additional, Amin, Hardik, additional, Stretz, Hans Christoph, additional, Narula, Reshma, additional, Jasne, Adam, additional, Sansing, Lauren, additional, Agarwal, Tijil, additional, Jasak, Sara, additional, Fontaine, Briana, additional, King, Zachary, additional, Kuohn, Lindsey, additional, Orgass, Hailey, additional, Leary, Megan, additional, Nye, Joan, additional, Halbert, Kelsey, additional, Nystrom, Karin, additional, Neuschatz, Kaile, additional, Petrucci, Dawn, additional, Coppola, Anna, additional, Tarpley, Jason, additional, Joyce, Treasure, additional, Hou, Sam, additional, Umekubo, Mark, additional, Nakamura, Catrice, additional, Ovando, Renee, additional, Zuniga, Diana, additional, Nien, Yih Lin, additional, Basto, Fernando Mayor, additional, Arch, Allison, additional, Jong, Laura, additional, Conrad, William, additional, Abbott, Tara, additional, Yao, Jay, additional, Caganap, Scott, additional, Jordan, John, additional, Teitelbaum, George, additional, Darflinger, Robert, additional, Bain, Marianne, additional, Budzik, Ronald, additional, Czerniak, Jennifer, additional, Groezinger, Katherine, additional, Hicks II, William, additional, Kaskar, Omran, additional, Katz, Brian, additional, Loochtan, Aaron, additional, Pema, Peter, additional, Rai, Vivek, additional, Vora, Nirav, additional, Brown, Amanda, additional, Goodman, Diane, additional, Danenbergs, Barb, additional, Gossett, Monica, additional, Chung, Jong-Won, additional, Jeon, Pyoung, additional, Kim, Keon Ha, additional, Lim, Yun Jeong, additional, Nam, Hyo Suk, additional, Kim, Young Dae, additional, Park, HyungJong, additional, Hwang, In Gun, additional, Ha, Wooseok, additional, Choi, Jin Kyo, additional, Jeong, Kyungsun, additional, Park, Hee-Kwon, additional, Yoon, Cindy, additional, Kim, Bo-Kyung, additional, Kim, Chang-hyun, additional, Yoo, Joonsang, additional, Hong, Jeong-Ho, additional, Park, Hyungjong, additional, Kim, Sohyeon, additional, Choi, Moonkyung, additional, Bae, Hyoeun, additional, Lee, Jun Seok, additional, Lee, Jae-Joon, additional, Jun, Go-Eun, additional, Jeon, Sujeong, additional, Campbell, Bruce, additional, Mitchell, Peter, additional, Yassi, Nawaf, additional, Davis, Stephen, additional, Donnan, Geoffrey, additional, Parsons, Mark, additional, Yan, Bernard, additional, Dowling, Richard, additional, Bush, Steven, additional, Wu, Teddy, additional, Shah, Darshan, additional, Zhao, Henry, additional, Salvaris, Patrick, additional, Alemseged, Fana, additional, Ng, Felix, additional, Williams, Cameron, additional, Balabanski, Anna, additional, Dos Santos, Angela, additional, Ng, Jo-Lyn, additional, McDonald, Amy, additional, Jackson, David, additional, Tsoleridis, Jessica, additional, Pesavento, Lauren, additional, Kleinig, Timothy John, additional, Nurs, Roy Drew, additional, Cranefield, Jennifer, additional, Scroop, Rebecca, additional, Cagi, Lavenia, additional, Harvey, Jackson, additional, Waters, Michael, additional, Brennan, Robert, additional, O'Hare, Alan, additional, Power, Sarah, additional, Williams, David, additional, Boyle, Karl, additional, Moynihan, Barry, additional, Liddy, Ann-Marie, additional, Large, Margaret, additional, Cullen, Ailbhe, additional, Walsh, Roisin, additional, Martin, Emma, additional, Lynch, Julie, additional, McElroy, Sinéad, additional, Coveney, Sarah, additional, Deegan, Caroline, additional, Horgan, Gillian, additional, Kelly, Peter, additional, Laffan, Aoife, additional, Llamas-Osorio, Yudy, additional, Lynch, Catherine, additional, Mac Mahon, Peter, additional, Marnane, Michael, additional, McCabe, John, additional, Burns, Paul, additional, Tauro, Suzanne, additional, Cuddy, Sarah, additional, Rennie, Ian, additional, Smyth, Graham, additional, Flynn, Peter, additional, Wiggam, Ivan, additional, Kerr, Enda, additional, Gordon, Patricia, additional, Fearon, Patricia, additional, Roberts, Geralt, additional, Patterson, Cathy, additional, Adams, Karen, additional, Wells, Brian, additional, McFarland, Margaret, additional, Moreira, Tiago, additional, Sjöstrand, Christina, additional, Mazya, Michael, additional, Almqvist, Håkan, additional, Wahlgren, Nils, additional, Steinberg, Anna, additional, Cooray, Charith, additional, Eriksson, Einar, additional, Thorén, Magnus, additional, Keselman, Boris, additional, Ahmed, NIaz, additional, Holmberg, Åke, additional, Axelsson, Maria, additional, Berglund, Annika, additional, Golsari, Amir, additional, Hoppe, Julia, additional, Deb-Chatterji, Milani, additional, Cheng, Bastian, additional, Barrow, Ewgenia, additional, Schlemm, Eckhard, additional, Lettow, Iris, additional, Jensen, Märit, additional, Otto, Dagmar, additional, Jaramillo, Kirsten, additional, Appelbohm, Hannes, additional, Fiehler, Jens, additional, Bester, Maxim, additional, Schönfeld, Michael, additional, Brekenfeld, Caspar, additional, Holst, Brigitte, additional, Wortmann, Ginette, additional, Koch, Friederike, additional, Gerber, Johannes, additional, Abramyuk, Andrij, additional, Kaiser, Daniel, additional, Winzer, Simon, additional, Prakapenia, Alexandra, additional, Pallesen, Lars-Peder, additional, Siepmann, Timo, additional, Barlinn, Kristian, additional, Haase, Kathrin, additional, Sauer, Angela, additional, Liman, Jan, additional, Brehm, Alex, additional, Maus, Volker, additional, Hollstein, Nicole, additional, Reinke, Annika, additional, Neitz, Gustav, additional, Schnieder, Marlena, additional, Schwarz, Margret, additional, Ibrahim, Allam, additional, Müller, Julia, additional, Meister, Stefanie, additional, Bäumle, Berit, additional, Pilgram-Pastor, Sara, additional, Wallocha, Marta, additional, Stauder, Michael, additional, Celik, Ekin, additional, Stracke, Paul, additional, Müller, Nicole, additional, Weber, Ralph, additional, Velktamp, Roland, additional, Ringleb, Peter Arthur, additional, Heyse, Miriam, additional, Amiri, Hemasse, additional, Mundiyanapurath, Sibu, additional, Chen, Min, additional, Bevrle, Elisabeth, additional, Beck, Perdita, additional, Möhlenbruch, Markus alfred, additional, Potvin, Alphonse, additional, Harris, Cameron, additional, Wang, Chong, additional, Adams, Corey, additional, Mayor, Diana, additional, Garman, Dave, additional, Chau, Davis, additional, Wu, Jane, additional, Lunn, Janet, additional, Bermanis, Liat, additional, Teyes, Lucy, additional, Constant, Marc, additional, Galsim, Maria, additional, Helbin, Michael, additional, Leroux, Michelle, additional, Felix, Nicole, additional, Bendre, Nilima, additional, Cuthbert, Sandra, additional, Brokx, Steve, additional, Zhang, Yichuan, additional, Lingham, Trudy, additional, Kohli, Yatika, additional, Salter, Michael, additional, Liebeschuetz, Joseph, additional, Hofmann, Frieder, additional, Constant, John, additional, Soeder, Tom, additional, Snoke, Kara, additional, Bologa, Monica, additional, Stahl, Kimberly, additional, and Graziewicz, Maria, additional
Published: 2020
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36. sj-pdf-2-wso-10.1177_17474930211005740 - Supplemental material for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows

Author: Nogueira, Raul G, Haussen, Diogo C, Liebeskind, David S, Jovin, Tudor G, Rishi Gupta, Saver, Jeffrey L, Jadhav, Ashutosh P, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Mohammaden, Mahmoud H, Yanchang Zhang, Morgan, Patricia, Minyi Ji, Bartolini, Bruno, English, Joey, Albers, Gregory W, Mlynash, Michael, Lansberg, Maarten G, Frankel, Michael R, Vitor M Pereira, and Veznedaroglu, Erol
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-pdf-2-wso-10.1177_17474930211005740 for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows by Raul G Nogueira, Diogo C Haussen, David S Liebeskind, Tudor G Jovin, Rishi Gupta, Jeffrey L Saver, Ashutosh P Jadhav, Ronald F Budzik, Blaise Baxter, Antonin Krajina, Alain Bonafe, Ali Malek, Ana Paula Narata, Mahmoud H Mohammaden, Yanchang Zhang, Patricia Morgan, Minyi Ji, Bruno Bartolini, Joey English, Gregory W Albers, Michael Mlynash, Maarten G Lansberg, Michael R Frankel, Vitor M Pereira, Erol Veznedaroglu and for the Trevo Registry, SWIFT Prime, DEFUSE 3 and DAWN Trial Investigators in International Journal of Stroke
Published: 2021
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37. sj-pdf-1-wso-10.1177_17474930211005740 - Supplemental material for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows

Author: Nogueira, Raul G, Haussen, Diogo C, Liebeskind, David S, Jovin, Tudor G, Rishi Gupta, Saver, Jeffrey L, Jadhav, Ashutosh P, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Mohammaden, Mahmoud H, Yanchang Zhang, Morgan, Patricia, Minyi Ji, Bartolini, Bruno, English, Joey, Albers, Gregory W, Mlynash, Michael, Lansberg, Maarten G, Frankel, Michael R, Vitor M Pereira, and Veznedaroglu, Erol
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-pdf-1-wso-10.1177_17474930211005740 for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows by Raul G Nogueira, Diogo C Haussen, David S Liebeskind, Tudor G Jovin, Rishi Gupta, Jeffrey L Saver, Ashutosh P Jadhav, Ronald F Budzik, Blaise Baxter, Antonin Krajina, Alain Bonafe, Ali Malek, Ana Paula Narata, Mahmoud H Mohammaden, Yanchang Zhang, Patricia Morgan, Minyi Ji, Bruno Bartolini, Joey English, Gregory W Albers, Michael Mlynash, Maarten G Lansberg, Michael R Frankel, Vitor M Pereira, Erol Veznedaroglu and for the Trevo Registry, SWIFT Prime, DEFUSE 3 and DAWN Trial Investigators in International Journal of Stroke
Published: 2021
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38. SELECTion criteria for large core trials: dogma or data?

Author: Sarraj, Amrou Campbell, Bruce Ribo, Marc Hussain, Muhammad Shazam Chen, Michael Abraham, Michael G. Lansberg, Maarten G. Mendes Pereira, Vitor Blackburn, Spiros Sitton, Clark W. and Budzik, Ronald F. Perez de la Ossa, Natalia Arenillas, Juan F. Wu, Teddy Blasco, Jordi Mullen, Michael Schaafsma, Joanna Tsai, Jenny P. Sangha, Navdeep Kozak, Osman and Gibson, Daniel Warach, Steven Cordato, Dennis Manning, Nathan W. Kleinig, Timothy J. Olivot, Jean-Marc Elijovich, Lucas Tsivgoulis, Georgios Alexandrov, Andrei Jabbour, Pascal Yan, Bernard Kasner, Scott E. Arthur, Adam S. and Parsons, Mark Grotta, James C. Hassan, Ameer E. Albers, Gregory W. SELECT2 Investigators SELECT2 Steering Comm
Published: 2021

39. Clinical and Neuroimaging Outcomes of Direct Thrombectomy vs Bridging Therapy in Large Vessel Occlusion Analysis of the SELECT Cohort Study

Author: Sarraj, Amrou Grotta, James Albers, Gregory W. Hassan, Ameer E. Blackburn, Spiros Day, Arthur Sitton, Clark Abraham, Michael Cai, Chunyan Dannenbaum, Mark Pujara, Deep and Hicks, William Budzik, Ronald Vora, Nirav Arora, Ashish and Alenzi, Bader Tekle, Wondwossen G. Kamal, Haris Mir, Osman and Barreto, Andrew D. Lansberg, Maarten Gupta, Rishi and Martin-Schild, Sheryl Savitz, Sean Tsivgoulis, Georgios and SELECT Investigators
Abstract: Objective To evaluate the comparative safety and efficacy of direct endovascular thrombectomy (dEVT) compared to bridging therapy (BT; IV tissue plasminogen activator + EVT) and to assess whether BT potential benefit relates to stroke severity, size, and initial presentation to EVT vs non-EVT center. Methods In a prospective multicenter cohort study of imaging selection for endovascular thrombectomy (Optimizing Patient Selection for Endovascular Treatment in Acute Ischemic Stroke [SELECT]), patients with anterior circulation large vessel occlusion (LVO) presenting to EVT-capable centers within 4.5 hours from last known well were stratified into BT vs dEVT. The primary outcome was 90-day functional independence (modified Rankin Scale [mRS] score 0-2). Secondary outcomes included a shift across 90-day mRS grades, mortality, and symptomatic intracranial hemorrhage. We also performed subgroup analyses according to initial presentation to EVT-capable center (direct vs transfer), stroke severity, and baseline infarct core volume. Results We identified 226 LVOs (54% men, mean age 65.6 +/- 14.6 years, median NIH Stroke Scale [NIHSS] score 17, 28% received dEVT). Median time from arrival to groin puncture did not differ in patients with BT when presenting directly (dEVT 1.43 [interquartile range (IQR) 1.13-1.90] hours vs BT 1.58 [IQR 1.27-2.02] hours, p = 0.40) or transferred to EVT-capable centers (dEVT 1.17 [IQR 0.90-1.48] hours vs BT 1.27 [IQR 0.97-1.87] hours, p = 0.24). BT was associated with higher odds of 90-day functional independence (57% vs 44%, adjusted odds ratio [aOR] 2.02, 95% confidence interval [CI] 1.01-4.03, p = 0.046) and functional improvement (adjusted common OR 2.06, 95% CI 1.18-3.60, p = 0.011) and lower likelihood of 90-day mortality (11% vs 23%, aOR 0.20, 95% CI 0.07-0.58, p = 0.003). No differences in any other outcomes were detected. In subgroup analyses, patients with BT with baseline NIHSS scores = 15 (aOR 1.05, 95% CI 0.40-2.74, p = 0.92). Similarly, functional outcomes improvements with BT were detected in patients with core volume strata (ischemic core = 50 cm(3): aOR 0.41, 95% CI 0.01-16.02, p = 0.64) and transfer status (transferred: aOR 2.21, 95% CI 0.93-9.65, p = 0.29 vs direct to EVT center: aOR 1.84, 95% CI 0.80-4.23, p = 0.15). Conclusions BT appears to be associated with better clinical outcomes, especially with milder NIHSS scores, smaller presentation core volumes, and those who were “dripped and shipped.” We did not observe any potential benefit of BT in patients with more severe strokes.
Published: 2021

40. sj-pdf-1-wso-10.1177_17474930211006304 - Supplemental material for Influence of time to endovascular stroke treatment on outcomes in the early versus extended window paradigms

Author: Nogueira, Raul G, Jovin, Tudor G, Haussen, Diogo C, Rishi Gupta, Ashutov Jadhav, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Shields, Ryan, Yanchang Zhang, Morgan, Patricia, Bartolini, Bruno, English, Joey, Mohammaden, Mahmoud, Frankel, Michael R, Liebeskind, David S, and Veznedaroglu, Erol
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-pdf-1-wso-10.1177_17474930211006304 for Influence of time to endovascular stroke treatment on outcomes in the early versus extended window paradigms by Raul G Nogueira, Tudor G Jovin, Diogo C Haussen, Rishi Gupta, Ashutov Jadhav, Ronald F Budzik, Blaise Baxter, Antonin Krajina, Alain Bonafe, Ali Malek, Ana Paula Narata, Ryan Shields, Yanchang Zhang, Patricia Morgan, Bruno Bartolini, Joey English, Mahmoud Mohammaden, Michael R Frankel, David S Liebeskind, Erol Veznedaroglu and for the Trevo Registry and DAWN Trial Investigators in International Journal of Stroke
Published: 2021
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41. SELECTion criteria for large core trials: dogma or data?

Author: Sarraj, Amrou, primary, Campbell, Bruce, additional, Ribo, Marc, additional, Hussain, Muhammad Shazam, additional, Chen, Michael, additional, Abraham, Michael G, additional, Lansberg, Maarten G, additional, Mendes Pereira, Vitor, additional, Blackburn, Spiros, additional, Sitton, Clark W, additional, Budzik, Ronald F, additional, Pérez de la Ossa, Natalia, additional, Arenillas, Juan F, additional, Wu, Teddy, additional, Blasco, Jordi, additional, Mullen, Michael, additional, Schaafsma, Joanna, additional, Tsai, Jenny P, additional, Sangha, Navdeep, additional, Kozak, Osman, additional, Gibson, Daniel, additional, Warach, Steven, additional, Cordato, Dennis, additional, Manning, Nathan W, additional, Kleinig, Timothy J, additional, Olivot, Jean-Marc, additional, Elijovich, Lucas, additional, Tsivgoulis, Georgios, additional, Alexandrov, Andrei, additional, Jabbour, Pascal, additional, Yan, Bernard, additional, Kasner, Scott E, additional, Arthur, Adam S, additional, Parsons, Mark, additional, Grotta, James C, additional, Hassan, Ameer E, additional, and Albers, Gregory W, additional
Published: 2021
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42. Abstract P548: Multiple Attempts Complete Reperfusion versus Single Pass Successful Reperfusion: A Sub-Analysis From the Select Study

Author: Hassan, Ameer E, primary, Blackburn, Spiros, additional, Abraham, Michael G, additional, G Tekle, Wondwossen, additional, Vora, Nirav, additional, Dannenbaum, Mark, additional, Day, Arthur, additional, Dibas, Mahmoud, additional, Pujara, Deep, additional, Shaker, Faris, additional, Hellinger, Kevin, additional, Edgell, Randi, additional, Budzik, Ronald, additional, Gupta, Rishi, additional, and Sarraj, Amrou, additional
Published: 2021
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43. Abstract P14: Per Pass Clot Retrieval Technique: Interim Analysis of the Excellent Registry

Author: Siddiqui, Adnan H, primary, Waqas, Muhammad, additional, Andersson, Tommy, additional, De Meyers, Simon F, additional, Fiehler, Jens, additional, Hacke, Werner, additional, Hanel, Ricardo, additional, Jovin, Tudor, additional, Liebeskind, David S, additional, Yoo, Albert J, additional, Zaidat, Osama O, additional, Haussen, Diogo C, additional, Inoa, Violiza, additional, Woodward, Keith, additional, Humphries, William E, additional, Jabbour, Pascal M, additional, Francois, Olivier, additional, Dashti, Shervin R, additional, Bozorgchami, Hormozd, additional, Levy, Elad, additional, Budzik, Ronald, additional, Schirmer, Clemens, additional, Taqi, Muhammad A, additional, Estrade, Laurent, additional, De Leacy, Reade A, additional, Boor, Stephan, additional, Hussain, Shazam, additional, Puri, Ajit S, additional, and Nogueira, Raul G, additional
Published: 2021
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44. Abstract P137: Large Vessel Occlusion Prediction Scale Thresholds That Are Sensitive for DAWN Trial Participants

Author: Keenan, Kevin J, primary, Smith, Wade S, additional, Jadhav, Ashutosh P, additional, Haussen, Diogo C, additional, Budzik, Ronald F, additional, Bonafe, Alain, additional, Bhuva, Parita, additional, Yavagal, Dileep R, additional, Ribo, Marc, additional, Cognard, Christophe, additional, Hanel, Ricardo A, additional, Hassan, Ameer E, additional, Sila, Cathy A, additional, Saver, Jeffrey L, additional, Liebeskind, David S, additional, Jovin, Tudor G, additional, and Nogueira, Raul G, additional
Published: 2021
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45. POSITIVE: Perfusion imaging selection of ischemic stroke patients for endovascular therapy

Author: Mocco, J, primary, Siddiqui, Adnan H, additional, Fiorella, David, additional, Alexander, Michael J, additional, Arthur, Adam S, additional, Baxter, Blaise W, additional, Budzik, Ronald F, additional, Froehler, Michael T, additional, Hanel, Ricardo A, additional, Lena, Jonathan, additional, Persaud, Steven, additional, Puri, Ajit S, additional, Rai, Ansaar T, additional, Wintermark, Max, additional, Woodward, Keith, additional, Zhang, Xiangnan, additional, and Turk, Aquilla, additional
Published: 2021
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46. First pass effect in patients with large vessel occlusion strokes undergoing neurothrombectomy: insights from the Trevo Retriever Registry

Author: Jadhav, Ashutosh P, primary, Desai, Shashvat M, additional, Budzik, Ronald F, additional, Gupta, Rishi, additional, Baxter, Blaise, additional, English, Joey D, additional, Bartolini, Bruno Mario, additional, Krajina, Antonin, additional, Haussen, Diogo C, additional, Nogueira, Raul G, additional, Liebeskind, David, additional, and Veznedaroglu, Erol, additional
Published: 2021
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47. Endovascular therapy in the distal neurovascular territory: results of a large prospective registry

Author: Nogueira, Raul G, primary, Mohammaden, Mahmoud H, additional, Haussen, Diogo C, additional, Budzik, Ronald F, additional, Gupta, Rishi, additional, Krajina, Antonin, additional, English, Joey D, additional, Malek, Ali R, additional, Sarraj, Amrou, additional, Narata, Ana Paula, additional, Taqi, Muhammad Asif, additional, Frankel, Michael R, additional, Miller, Timothy Ryan, additional, Grobelny, Thomas, additional, Baxter, Blaise W, additional, Bartolini, Bruno Mario, additional, Jenkins, Paul, additional, Estrade, Laurent, additional, Liebeskind, David, additional, and Veznedaroglu, Erol, additional
Published: 2020
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48. Endovascular thrombectomy in patients with large core ischemic stroke: a cost-effectiveness analysis from the SELECT study

Author: Sarraj, Amrou, primary, Pizzo, Elena, additional, Lobotesis, Kyriakos, additional, Grotta, James C, additional, Hassan, Ameer E, additional, Abraham, Michael G, additional, Blackburn, Spiros, additional, Day, Arthur L, additional, Dannenbaum, Mark J, additional, Hicks, William, additional, Vora, Nirav A, additional, Budzik, Ronald F, additional, Sharrief, Anjail Z, additional, Martin-Schild, Sheryl, additional, Sitton, Clark W, additional, Pujara, Deep Kiritbhai, additional, Lansberg, Maarten G, additional, Gupta, Rishi, additional, Albers, Gregory W, additional, and Kunz, Wolfgang G, additional
Published: 2020
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49. Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

Author: Broderick, Joseph P., Palesch, Yuko Y., Demchuk, Andrew M., Yeatts, Sharon D., Khatri, Pooja, Hill, Michael D., Jauch, Edward C., Jovin, Tudor G., Yan, Bernard, Silver, Frank L., von Kummer, Rüdiger, Molina, Carlos A., Demaerschalk, Bart M., Budzik, Ronald, Clark, Wayne M., Zaidat, Osama O., Malisch, Tim W., Goyal, Mayank, Schonewille, Wouter J., Mazighi, Mikael, Engelter, Stefan T., Anderson, Craig, Spilker, Judith, Carrozzella, Janice, Ryckborst, Karla J., Janis, Scott L., Martin, Renée H., Foster, Lydia D., and Tomsick, Thomas A.
Published: 2013
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50. Clinical effectiveness of endovascular stroke treatment in the early and extended time windows.

Author: Nogueira, Raul G, Haussen, Diogo C, Liebeskind, David S, Jovin, Tudor G, Gupta, Rishi, Saver, Jeffrey L, Jadhav, Ashutosh P, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Mohammaden, Mahmoud H, Zhang, Yanchang, Morgan, Patricia, Ji, Minyi, Bartolini, Bruno, English, Joey, and Albers, Gregory W
Subjects: TISSUE plasminogen activator, CLINICAL trials, MEDICAL registries
Abstract: Background: The clinical efficacy of mechanical thrombectomy has been unequivocally demonstrated in multiple randomized clinical trials. However, these studies were performed in carefully selected centers and utilized strict inclusion criteria. Aim: We aimed to assess the clinical effectiveness of mechanical thrombectomy in a prospective registry. Methods: A total of 2008 patients from 76 sites across 12 countries were enrolled in a prospective open-label mechanical thrombectomy registry. Patients were categorized into the corresponding cohorts of the SWIFT-Prime, DAWN, and DEFUSE 3 trials according to the basic demographic and clinical criteria without considering specific parenchymal imaging findings. Baseline and outcome variables were compared across the corresponding groups. Results: As compared to the treated patients in the actual trials, registry-derived patients tended to be younger and had lower baseline ASPECTS. In addition, time to treatment was earlier and the use of intravenous tissue plasminogen activator (IV-tPA) and general anesthesia were higher in DAWN- and DEFUSE-3 registry derived patients versus their corresponding trials. Reperfusion rates were higher in the registry patients. The rates of 90-day good outcome (mRS0-2) in registry-derived patients were comparable to those of the patients treated in the corresponding randomized clinical trials (SWIFT-Prime, 64.5% vs. 60.2%; DAWN, 50.4% vs. 48.6%; Beyond-DAWN: 52.4% vs. 48.6%; DEFUSE 3, 52% vs. 44.6%, respectively; all P > 0.05). Registry-derived patients had significant less disability than the corresponding randomized clinical trial controls (ordinal modified Rankin Scale (mRS) shift odds ratio (OR), P < 0.05 for all). Conclusion: Our study provides favorable generalizability data for the safety and efficacy of thrombectomy in the "real-world" setting and supports that patients may be safely treated outside the constraints of randomized clinical trials. [ABSTRACT FROM AUTHOR]
Published: 2022
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