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2. Vulnerability, Discrimination and Xenophobia. Brief 3. UNICEF Innocenti Research Brief 2022-03

Author

UNICEF Office of Research – Innocenti (Italy), UK Aid, Kingdom of the Netherlands, United Nations Children's Fund (UNICEF), Middle East and North Africa Regional Office (MENA), Aslanishvli, T., Fischer, R., Kaplan, J., Subrahmanian, R., Bueno, O., Gill, M., Hovil, L., and Genovese, I.

Abstract

This series of briefs draws on the findings of multi-country research based on first-hand migration experiences of 1,634 children and young people moving between Somalia, Ethiopia, Sudan and Egypt (available at www.unicef-irc.org/child-migration-hoa). The briefs highlight findings that can inform decision makers when designing child-sensitive solutions for children on the move (COM), in line with relevant objectives of the Global Compact for Safe, Orderly and Regular Migration (GCM). This third brief in the series presents vulnerability, discrimination and xenophobia. [For Brief 1, see ED620508. For Brief 2, see ED620510.]

Published
2022

3. Access to Basic Services. Brief 2. UNICEF Innocenti Research Brief 2022-02

Author

United Nations Children’s Fund (UNICEF) (Italy), Innocenti Research Centre, UK Aid, Kingdom of the Netherlands, United Nations Children's Fund (UNICEF), Middle East and North Africa Regional Office (MENA), Aslanishvli, T., Fischer, R., Kaplan, J., Subrahmanian, R., Bueno, O., Gill, M., Hovil, L., and Genovese, I.

Abstract

This series of briefs draws on the findings of multi-country research based on first-hand migration experiences of 1,634 children and young people moving between Somalia, Ethiopia, Sudan and Egypt1 (available at www.unicef-irc.org/child-migration-hoa). The briefs highlight findings that can inform decision makers when designing child-sensitive solutions for children on the move (COM), in line with relevant objectives of the Global Compact for Safe, Orderly and Regular Migration (GCM). This second brief presents access to basic services. [For Brief 1, see ED620508. For Brief 3, see ED620509.]

Published
2022

4. Strengthening Child Protection Systems and Ending Child Immigration Detention. Brief 1. UNICEF Innocenti Research Brief 2022-01

Author

UNICEF Office of Research – Innocenti (Italy), UK Aid, Kingdom of the Netherlands, United Nations Children's Fund (UNICEF), Middle East and North Africa Regional Office (MENA), Aslanishvli, T., Fischer, R., Kaplan, J., Subrahmanian, R., Bueno, O., Gill, M., Hovil, L., and Genovese, I.

Abstract

This series of briefs draws on the findings of multi-country research based on first-hand migration experiences of 1,634 children and young people moving between Somalia, Ethiopia, Sudan and Egypt1 (available at www.unicef-irc.org/child-migration-hoa). The briefs highlight findings that can inform decision makers when designing child-sensitive solutions for children on the move (COM), in line with relevant objectives of the Global Compact for Safe, Orderly and Regular Migration (GCM). This first brief in the series presents strengthening child protection systems and ending child immigration detention. [For Brief 2, see ED620510. For Brief 3, see ED620509.]

Published
2022

5. TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy

Author

Martín, M., Stecklein, S.R., Gluz, O., Villacampa, G., Monte-Millán, M., Nitz, U., Cobo, S., Christgen, M., Brasó-Maristany, F., Álvarez, E.L., Echavarría, I., Conte, B., Kuemmel, S., Bueno-Muiño, C., Jerez, Y., Kates, R., Cebollero, M., Kolberg-Liedtke, C., Bueno, O., García-Saenz, J.Á., Moreno, F., Grischke, E.-M., Forstbauer, H., Braun, M., Warm, M., Hackmann, J., Uleer, C., Aktas, B., Schumacher, C., Wuerstleins, R., Graeser, M., zu Eulenburg, C., Kreipe, H.H., Gómez, H., Massarrah, T., Herrero, B., Paré, L., Bohn, U., López-Tarruella, S., Vivancos, A., Sanfeliu, E., Parker, J.S., Perou, C.M., Villagrasa, P., Prat, A., Sharma, P., and Harbeck, N.

Published
2024
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6. Mass irradiation of adult Aedes mosquitoes using a coolable 3D printed canister

Author

Balestrino, Fabrizio, Bimbilé Somda, Nanwintoum Séverin, Samuel, M., Meletiou, Sotiris, Bueno, O., Wallner, Thomas, Yamada, Hanano, Mamaï, Wadaka, Vreysen, Marc J.B., Bouyer, Jérémy, Balestrino, Fabrizio, Bimbilé Somda, Nanwintoum Séverin, Samuel, M., Meletiou, Sotiris, Bueno, O., Wallner, Thomas, Yamada, Hanano, Mamaï, Wadaka, Vreysen, Marc J.B., and Bouyer, Jérémy

Abstract

In the last decade, the use of the sterile insect technique (SIT) to suppress mosquito vectors have rapidly expanded in many countries facing the complexities of scaling up production and procedures to sustain large-scale operational programs. While many solutions have been proposed to improve mass production, sex separation and field release procedures, relatively little attention has been devoted to effective mass sterilization of mosquitoes. Since irradiation of pupae en masse has proven difficult to standardise with several variables affecting dose response uniformity, the manipulation of adult mosquitoes appears to be the most promising method to achieve effective and reliable sterilization of large quantities of mosquitoes. A 3D-printed phase change material based coolable canister was developed which can compact, immobilize and hold around 100,000 adult mosquitoes during mass radio sterilization procedures. The mass irradiation and compaction treatments affected the survival and the flight ability of Aedes albopictus and Aedes aegypti adult males but the use of the proposed irradiation canister under chilled conditions (6.7–11.3 °C) significantly improved their quality and performance. The use of this cooled canister will facilitate adult mass irradiation procedures in self-contained irradiators in operational mosquito SIT programmes.

Published
2024

7. A non-type (D) linear isometry

Author

Bueno, O. and Svaiter, B. F.

Subjects
Mathematics - Functional Analysis, 47H05, 49J52, 47N10
Abstract

Previous constructions of non-type (D) maximal monotone operators were based on the non-type (D) operators introduced by Gossez, and the construction of such operators or the proof that they were non-type (D) were not straightforward. The aim of this paper is to present a very simple non-type (D) linear isometry.

Published
2012

8. The brain decade in debate: I. Neurobiology of learning and memory

Author

Baddeley, A., Bueno, O, Cahill, L., Fuster, J.M., Izquierdo, I., McGaugh, J.L., Morris, R.G.M., Nadel, L., Routtenberg, A., Xavier, G., and Da Cunha, C.

Subjects
memory, learning, hippocampus, prefrontal cortex, amygdala, memory systemslong-term potentiation, hippocampus, neuroscience, mechanisms, lesions, rat
Abstract

This article is a transcription of an electronic symposium in which some active researchers were invited by the Brazilian Society for Neuroscience and Behavior (SBNeC) to discuss the last decade's advances in neurobiology of learning and memory. The way different parts of the brain are recruited during the storage of different kinds of memory (e.g., short-term vs long-term memory, declarative vs procedural memory) and even the property of these divisions were discussed. It was pointed out that the brain does not really store memories, bur stores traces of information that are later used to create memories, not always expressing a completely veridical picture of the past experienced reality. To perform this process different parts of the brain act as important nodes of the neural network that encode, store and retrieve the information that will be used to create memories. Some of the brain regions are recognizably active during the activation of short-term working memory (e.g., prefrontal cortex), or the storage of information retrieved as long-term explicit memories (e.g., hippocampus and related cortical areas) or the modulation of the storage of memories related to emotional events (e.g., amygdala). This does not mean that there is a separate neural structure completely supporting the storage of each kind of memory but means that these memories critically depend on the functioning of these neural structures. The current view is that there is no sense in talking about hippocampus-based or amygdala-based memory since this implies that there is a one-to-one correspondence. The present question to be solved is how systems interact in memory. The pertinence of attributing a critical role to cellular processes like synaptic tagging and protein kinase A activation to explain the memory storage processes at the cellular level was also discussed.

Published
2000

9. 216P Relationship between regulatory T lymphocytes (Treg): Related genes and pathological response to neoadjuvant docetaxel-carboplatin in early-stage triple-negative breast cancer (TNBC)

Author

Martín Lozano, R., primary, Roche-Molina, M., additional, Alvarez, E., additional, Del Monte-Millan, M., additional, Jerez Gilarranz, Y., additional, Moreno Anton, F., additional, García Saenz, J.Á., additional, Echavarria Diaz-Guardamino, I., additional, Massarrah, T., additional, Cebollero, M., additional, Ballesteros Garcia, A.I., additional, Bohn Sarmiento, U., additional, Gomez Moreno, H.L., additional, Fuentes, H.A., additional, Herrero Lopez, B., additional, Gamez Casado, S., additional, Bueno Muiño, C., additional, Bueno, O., additional, Lopez-Tarruella Cobo, S., additional, and Martin Jimenez, M., additional

Published
2022
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10. 141MO Pathological response and early survival data according to TNBCtype4 classifier in operable triple-negative breast cancer (TNBC) treated with neoadjuvant carboplatin and docetaxel

Author

Echavarria Diaz-Guardamino, I., primary, Lopez-Tarruella Cobo, S., additional, Del Monte-Millan, M., additional, Alvarez, E., additional, Jerez, Y., additional, Moreno Anton, F., additional, García Saenz, J.Á., additional, Massarrah, T., additional, Ocaña, I., additional, Cebollero, M., additional, Ballesteros Garcia, A.I., additional, Bohn Sarmiento, U., additional, Gomez, H., additional, Fuentes, H.A., additional, Herrero Lopez, B., additional, Gamez Casado, S., additional, Bueno, O., additional, Jiménez-Santos, M.J., additional, Roche-Molina, M., additional, and Martin Jimenez, M., additional

Published
2022
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11. 261P Subtyping of residual disease (RD) following neoadjuvant chemotherapy (NACT) for triple negative breast cancer (TNBC): Evolution and prognostic impact

Author

Diaz-Guardamino, I. Echavarria, Lopez-Tarruella Cobo, S., Del Monte-Millan, M., Alvarez, E., Gilarranz, Y. Jerez, Anton, F. Moreno, Saenz, J.Á. García, Massarrah, T., Ocaña, I., Cebollero, M., Garcia, A.I. Ballesteros, Sarmiento, U. Bohn, Gomez, H., Rivera, H. Fuentes, Lopez, B. Herrero, Polo, C., Bueno, O., Rahimi, P., Muiño, C. Bueno, and Jimenez, M. Martin

Published
2024
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16. How do energy balance-related behaviors cluster in adolescents?

Author

Collese, Tatiana Sadalla, De Moraes, Augusto César Ferreira, Fernández-Alvira, Juan Miguel, Michels, Nathalie, De Henauw, Stefaan, Manios, Yannis, Androutsos, Odysseas, Kafatos, Anthony, Widhalm, Kurt, Galfo, Myriam, Beghin, Laurent, Sjöström, Michael, Pedrero-Chamizo, Raquel, Carvalho, Heráclito Barbosa, Moreno, Luis A., Moreno, L. A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Fernández Alvira, J., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Iglesia, I., Velasco, P., Bel, S., Gracia-Marco, L., Mouratidou, T., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Ligia Díaz, E., Romeo, J., Veses, A., Puertollano, M. Angeles, Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, null, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Gutiérrez, A., Ortega, F. B., Ruiz, J. R., Artero, E. G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D’Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Louisa Cook, T., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Sjöström, M., Hagströmer, M., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Hurtig Wennlöf, A., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Lilja Hallberg, M., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, Jara, Albers, Ulrike, Pedrero, Raquel, Palacios, Gonzalo, Meléndez, Agustín, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Ortiz, Juan Carlos, Fuentes, Francisco, Torres, Rosa María, Navarro, Paloma, Collese, Tatiana Sadalla, De Moraes, Augusto César Ferreira, Fernández-Alvira, Juan Miguel, Michels, Nathalie, De Henauw, Stefaan, Manios, Yanni, Androutsos, Odyssea, Kafatos, Anthony, Widhalm, Kurt, Galfo, Myriam, Beghin, Laurent, Sjöström, Michael, Pedrero-Chamizo, Raquel, Carvalho, Heráclito Barbosa, Moreno, Luis A., Moreno, L. A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Fernández Alvira, J., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Iglesia, I., Velasco, P., Bel, S., Gracia-Marco, L., Mouratidou, T., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Ligia Díaz, E., Romeo, J., Veses, A., Puertollano, M. Angele, Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Gutiérrez, A., Ortega, F. B., Ruiz, J. R., Artero, E. G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D’Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Louisa Cook, T., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Sjöström, M., Hagströmer, M., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Hurtig Wennlöf, A., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Lilja Hallberg, M., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, Jara, Albers, Ulrike, Pedrero, Raquel, Palacios, Gonzalo, Meléndez, Agustín, Benito, Pedro J., Lorente, Juan José Gómez, Cañada, David, Urzanqui, Alejandro, Ortiz, Juan Carlo, Fuentes, Francisco, Torres, Rosa María, Navarro, Paloma, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Inserm, Université de Lille, CHU Lille, and Lille Inflammation Research International Center - U 995 [LIRIC]

Subjects
Male, medicine.medical_specialty, Parental education, Health (social science), Adolescent, Healthy eating, Disease cluster, socioeconomic status, parental education, 03 medical and health sciences, Screen time, 0302 clinical medicine, energy balance-related behaviors, Surveys and Questionnaires, Environmental health, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Cluster Analysis, Humans, Socioeconomic statu, adolescents, Cluster analysi, 030212 general & internal medicine, Exercise, Socioeconomic status, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, 030505 public health, 4. Education, Public health, Public Health, Environmental and Occupational Health, Feeding Behavior, Sedentary behavior, Country of origin, Cross-Sectional Studies, Social Class, Adolescent Behavior, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Sedentary Behavior, Energy Metabolism, 0305 other medical science, Psychology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Brazil, Energy balance-related behavior
Abstract

International audience; OBJECTIVES: To delineate the clustering of energy balance-related behaviors in adolescents and investigate whether these behaviors are associated with the household socioeconomic status and parental education level. METHODS: Two cross-sectional studies assessed information on sedentary behavior, physical activity, sugar-sweetened beverages and fruit and vegetable consumption, and sleep duration by self-reported questionnaires in adolescents (12.5-17.5 years old) from Maringa/Brazil (BRACAH Study; n = 682) and ten European cities (HELENA Study; n = 1252) from nine different countries. Gender-specific cluster analyses were performed separately for each study, applying a combination of hierarchical and non-hierarchical methods. RESULTS: Girls showed equivalent behaviors: Sedentary; Active; Unhealthy Eating; Healthy Eating; while boys differed (Brazilian: Sedentary; Active; Healthy Eating; European: Sedentary; Healthy; Unhealthy Eating). In Brazil, we found no association between socioeconomic status and parental education. In European girls, the high socioeconomic status and both parents' university degree were associated with Healthy Eating. In European boys, the high socioeconomic status was associated with Unhealthy Eating, and the mothers' university degree was associated with the Healthy cluster. CONCLUSIONS: Adolescents show Sedentary behavior, regardless of their sex, country of origin, or socioeconomic condition.

Published
2018

17. Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14)

Author

Bahlis, NJ, Baz, R, Harrison, SJ, Quach, H, Ho, S-J, Vangsted, AJ, Plesner, T, Moreau, P, Gibbs, SD, Coppola, S, Yang, X, Al Masud, A, Ross, JA, Bueno, O, Kaufman, JL, Bahlis, NJ, Baz, R, Harrison, SJ, Quach, H, Ho, S-J, Vangsted, AJ, Plesner, T, Moreau, P, Gibbs, SD, Coppola, S, Yang, X, Al Masud, A, Ross, JA, Bueno, O, and Kaufman, JL

Abstract

PURPOSE: Venetoclax is an oral BCL-2 inhibitor with single-agent activity in patients with relapsed or refractory multiple myeloma (RRMM) with t(11;14) translocation. Venetoclax efficacy in RRMM may be potentiated through combination with agents including bortezomib, dexamethasone, and daratumumab. METHODS: This phase I study (NCT03314181) evaluated venetoclax with daratumumab and dexamethasone (VenDd) in patients with t(11;14) RRMM and VenDd with bortezomib (VenDVd) in cytogenetically unselected patients with RRMM. Primary objectives included expansion-phase dosing, safety, and overall response rate. Secondary objectives included further safety analysis, progression-free survival, duration of response, time to progression, and minimal residual disease negativity. RESULTS: Forty-eight patients were enrolled, 24 each in parts 1 (VenDd) and 2 (VenDVd). There was one dose-limiting toxicity in part 1 (grade 3 febrile neutropenia, 800 mg VenDd). Common adverse events with VenDd and VenDVd included diarrhea (63% and 54%) and nausea (50% and 50%); grade ≥ 3 adverse events were observed in 88% in the VenDd group and 71% in the VenDVd group. One treatment-emergent death occurred in part 2 (sepsis) in the context of progressive disease, with no other infection-related deaths on study with medians of 20.9 and 20.4 months of follow-up in parts 1 and 2, respectively. The overall response rate was 96% with VenDd (all very good partial response or better [≥ VGPR]) and 92% with VenDVd (79% ≥ VGPR). The 18-month progression-free survival rate was 90.5% (95% CI, 67.0 to 97.5) with VenDd and 66.7% (95% CI, 42.5 to 82.5) with VenDVd. CONCLUSION: VenDd and VenDVd produced a high rate of deep and durable responses in patients with RRMM. These results support continued evaluation of venetoclax with daratumumab regimens to treat RRMM, particularly in those with t(11;14).

Published
2021

20. Proteomic and Transcriptomic Approaches to Study Global Genome Expression in Rhizobium etli and Sinorhizobium meliloti

Author

Encarnación, S., Salazar, E., Martínez, G., Hernández, M., Reyes, A., Vargas, M. del C., Contreras, S., Elizalde, M., Noguez, R., Meneses, N., Bueno, O., Sánchez, R., Mora, Y., Mora, J., Dakora, Felix D., editor, Chimphango, Samson B. M., editor, Valentine, Alex J., editor, Elmerich, Claudine, editor, and Newton, William E., editor

Published
2008
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31. Cyprinid herpesvirus 3 evolves in vitro through an assemblage of haplotypes that alternatively become dominant or under-represented

Author

Klafack, S., Fiston-Lavier, A. S., Bergmann, S. M., Hammoumi, S., Schroder, L., Fuchs, W., Lusiastuti, A., Lee, P. Y., Heredia, S. V., Gosselin-Grenet, A. S., Avarre, Jean-Christophe, Amoyal, C., Amraoui, H., Bigourdan, A., Boujandir, I., Bueno, O., Cotteux, B., de San Nicolas, N., Delattre, R., Diouf, M. B., Dussaut, R., Gawron, K., Imbert, J. B., Mouilhi, H., Nifaut, E., Pages, A., Platon, L., Sanchez, S., Simon, L., Sobry, H., Souche, M., Taillefer, B., Guemgne, E. N., Sacchi, O., Diouf, A., Ouzerdine, A. L., Durand, F., Brooke, J., Cremaschi, J., Massaviol, M., Hamouma, M., Salma, M., Soulie, M., Delorme, Q., Virgoulay, T., Klein, Valentin, Antoine, Y., Berne, A., Gaal, C., and Master Student Consortium

Subjects
virus evolution, cell culture passages, haplotype sequence, Cyprinid herpesvirus 3
Abstract

Viruses are able to evolve in vitro by mutations after serial passages in cell cultures, which can lead to either a loss, or an increase, of virulence. Cyprinid herpesvirus 3 (CyHV-3), a 295-kb double-stranded DNA virus, is the etiological agent of the koi herpesvirus disease (KHVD). To assess the influence of serial passages, an isolate of CyHV-3 (KHV-T) was passaged 99 times onto common carp brain (CCB) cells, and virus virulence was evaluated during passages through the experimental infections of common carp. After 78 CCB passages, the isolate was much less virulent than the original form. A comparative genomic analysis of these three forms of KHV-T (P0, P78 and P99) revealed a limited number of variations. The largest one was a deletion of 1363 bp in the predicted ORF150, which was detected in P78, but not in P99. This unexpected finding was confirmed by conventional PCR and digital PCR. The results presented here primarily suggest that, CyHV-3 evolves, at least in vitro, through an assemblage of haplotypes that alternatively become dominant or under-represented.

Published
2019

38. PS1375 UPDATED SAFETY AND EFFICACY FROM A PHASE 2 STUDY OF VENETOCLAX PLUS CARFILZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA

Author

Costa, L., primary, Stadtmauer, E., additional, Davies, F., additional, Monohan, G., additional, Kovacsovics, T., additional, Burwick, N., additional, Jakubowiak, A., additional, Kaufman, J., additional, Hong, W.-J., additional, Freise, K., additional, Ross, J., additional, Pesko, J., additional, Munasinghe, W., additional, Gudipati, S., additional, Mudd, S., additional, Bueno, O., additional, and Kumar, S., additional

Published
2019
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42. Clustering of Multiple Lifestyle Behaviors and Health-related Fitness in European Adolescents

Author

Cuenca García, Magdalena, Huybrechts, Inge, Ruiz, Jonatan R., Ortega, Francisco B., Ottevaere, Charlene, González Gross, Marcela, Moreno, Luis A., Vicente Rodríguez, Germán, Molnár, Denés, Polito, Angela, Manios, Yannis, Plada, Maria, Vanhelst, Jeremy, Widhalm, Kurt, Sjöström, Michael, Kersting, Mathilde, Castillo, Manuel J., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Cuenca García M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, Cuenca García, Magdalena, Huybrechts, Inge, Ruiz, Jonatan R., Ortega, Francisco B., Ottevaere, Charlene, González Gross, Marcela, Moreno, Luis A., Vicente Rodríguez, Germán, Molnár, Dené, Polito, Angela, Manios, Yanni, Plada, Maria, Vanhelst, Jeremy, Widhalm, Kurt, Sjöström, Michael, Kersting, Mathilde, Castillo, Manuel J., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Cuenca García, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Subjects
Male, Gerontology, Adolescent, Physical activity, Medicine (miscellaneous), Motor Activity, Screen time, Surveys and Questionnaires, Intervention (counseling), Activities of Daily Living, Cluster Analysis, Humans, Students, Cluster analysis, Aerobic capacity, Analysis of Variance, Nutrition and Dietetics, Health related, Feeding Behavior, Healthy diet, Europe, HELENA study, Female, Homework, Analysis of variance, Sedentary Behavior, Psychology
Abstract

Objective To explore the clustering of different lifestyle behaviors and whether this clustering differs by gender, age, and health-related fitness. Design Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study. Setting Ten European cities. Participants A total of 2,084 adolescents (12.5–17.5 years). Main Outcome Measures Four lifestyle behaviors were assessed by self-administered questionnaires: moderate to vigorous physical activity, homework time, screen time, and diet. Health-related fitness components (aerobic capacity, strength, speed-agility, and body composition) were assessed. Analysis Hierarchical method and κ -means cluster analysis. Analysis of variance tests. Results Five clusters were identified: Healthy diet and Active, Healthy diet and Academic, Healthy diet and Inactive, Unhealthy diet and Screen user, and Unhealthy diet and Active. Younger adolescents were more active and followed a healthier diet than older adolescents. Older boys devoted more time to screen use, whereas older girls devoted more time to homework. Boys in the Healthy diet and Active cluster presented higher aerobic capacity and speed-agility, whereas girls presented higher aerobic capacity, strength, and speed-agility. Conclusions and Implications Clustering of different lifestyle behaviors is observed. Different healthy lifestyles do not always come together and clusters are associated with gender, age, and health-related fitness, but not with body composition. These differences need to be considered when developing intervention strategies for the prevention of unhealthy habits.

Published
2013

43. Cardiorespiratory fitness in males, and upper limbs muscular strength in females, are positively related with 25-hydroxyvitamin D plasma concentrations in European adolescents: the HELENA study

Author

Valtueña Santamaría, J., Gracia Marco, L., Huybrechts, I., Breidenassel, C., Ferrari, M., Gottrand, F., Dallongeville, J., Sioen, I., Gutierrez, A., Kersting, M., Kafatos, A., Manios, Y., Widhalm, K., Moreno, L. A., González Gross, M., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sáchez J, Kesting M, Sjostrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Gracia Marco L, Mouratidou T, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Kersting M, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D' Acapito P, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, Valtueña Santamaría, J., Gracia Marco, L., Huybrechts, I., Breidenassel, C., Ferrari, M., Gottrand, F., Dallongeville, J., Sioen, I., Gutierrez, A., Kersting, M., Kafatos, A., Manios, Y., Widhalm, K., Moreno, L. A., González Gross, M., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sáchez, J, Kesting, M, Sjostrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Gracia Marco, L, Mouratidou, T, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Kersting, M, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D' Acapito, P, Ferrari, M, Galfo, M, Donne, Cl, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Subjects
Male, medicine.medical_specialty, Adolescent, European Continental Ancestry Group, Physical fitness, Physical strength, White People, vitamin D deficiency, Upper Extremity, Cardiovascular Disease, Internal medicine, medicine, Vitamin D and neurology, Humans, Muscle Strength, Vitamin D, Adiposity, Cross-Sectional Studie, business.industry, Medicine (all), VO2 max, Cardiorespiratory fitness, General Medicine, Vitamin D Deficiency, medicine.disease, Obesity, Europe, Cross-Sectional Studies, Endocrinology, Cardiovascular Diseases, Physical Fitness, Physical Fitne, Body Composition, Exercise Test, Female, business, Body mass index, Human
Abstract

Background: High prevalence of vitamin D insufficiency (

Published
2013

44. Active relatives and health-related physical fitness in European adolescents: The HELENA Study

Author

Martín Matillas, Miguel, Ortega, Francisco B., Ruiz, Jonatan R., Martínez Gómez, David, Vicente Rodríguez, Germán, Marcos, Ascensión, Béghin, Laurent, Kafatos, Anthony, González Gross, Marcela, Zaccaria, Maria, Molnár, Dénes, de Henauw, Stefaan, Sjöström, Michael, Moreno, Luis A., Castillo, Manuel J., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Castelló S, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz LE, Romeo J, Veses A, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Hagströmer M, Hurtig Wennlöf A, Hallström L, Patterson E, Kwak L, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Thomas S, Allchurch E, Burgess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Martín Matillas, Miguel, Ortega, Francisco B., Ruiz, Jonatan R., Martínez Gómez, David, Vicente Rodríguez, Germán, Marcos, Ascensión, Béghin, Laurent, Kafatos, Anthony, González Gross, Marcela, Zaccaria, Maria, Molnár, Déne, de Henauw, Stefaan, Sjöström, Michael, Moreno, Luis A., Castillo, Manuel J., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Castelló, S, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, Le, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Hagströmer, M, Hurtig Wennlöf, A, Hallström, L, Patterson, E, Kwak, L, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.

Subjects
Adult, Male, Multi-stage fitness test, Adolescent, Friend, Movement, Physical fitness, Physical activity, Friends, Physical Therapy, Sports Therapy and Rehabilitation, Sister, Social Environment, Physical strength, Developmental psychology, Social support, Humans, Family, Orthopedics and Sports Medicine, Muscle Strength, Child, Exercise, Motor Skill, Analysis of Variance, business.industry, Social Support, Cardiorespiratory fitness, Lifestyle, Brother, Health-related fitness, Adolescence, Europe, Motor Skills, Physical Fitness, Sedentary Lifestyle, Physical Fitne, Female, Health-related fitne, Sedentary Behavior, business, Psychology, Human
Abstract

High physical fitness in childhood and adolescence is positively associated with favourable health-related outcomes. Our aim was to examine the relationship between relatives' (father, mother, brother, sister, and best friend) physical activity engagement and encouragement on adolescents' physical fitness. Adolescents were part of the HELENA study, a multi-centre study conducted in 10 cities from nine European countries in 2006-2008. Participants were 3288 adolescents (48% boys, 52% girls) aged 12.5-17.5 years with valid data on at least one of the three fitness variables studied: muscular strength (standing long jump), speed/agility (4×10 m shuttle run), and cardiorespiratory fitness (20 m shuttle run). The adolescents reported their relatives' physical activity engagement and encouragement. Analysis of covariance showed that relatives' physical activity engagement (father, mother, brother, and best friend) was positively related to cardiorespiratory fitness (P < 0.05); and mother's and sisters' physical activity engagement were positively associated with higher muscular strength in adolescents (P < 0.05). Furthermore, father's physical activity encouragement was positively linked to physical fitness (all fitness components) in adolescents (P < 0.05). Interventions aimed at improving physical fitness in young people might be more successful when family members, particularly mothers and fathers, are encouraged to engage in physical activity and support adolescents' physical activity. © 2012 Copyright Taylor and Francis Group, LLC.

Published
2012

45. Can differences in physical activity by socio-economic status in European adolescents be explained by differences in psychosocial correlates? A mediation analysis within the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study

Author

De Cocker, Katrien, Artero, Enrique G., De Henauw, Stefaan, Dietrich, Sabine, Gottrand, Frédéric, Béghin, Laurent, Hagströmer, Maria, Sjöström, Michael, Plada, Maria, Manios, Yannis, Mauro, Beatrice, Molnár, Dénes, Moreno, Luis A., Ottevaere, Charlene, Valtueña, Jara, Maes, Lea, De Bourdeaudhuij, Ilse, Moreno LA, Gottrand F, De Henauw S, Gonzalez Gross M, Gilbert C, Kafatos A, Libersa C, Sanchez J, Kersting M, Sjostrom M, Molnar D, Dallongeville J, Hall G, Maes L, Scalfi L, Melendez P, Fleta J, Casajus JA, Rodrıguez G, Tomas C, Mesana MI, Vicente Rodrıguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lazaro A, Bueno O, Leon JF, Garagorri JM, Bueno M, Lopez JP, Iglesia I, Velasco P, Bel S, Marcos A, Warnberg J, Nova E, Gomez S, Dıaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Torok K, Bokor S, Nagy E, Kovacs O, Repasi J, Codrington C, Plada M, Angeliki P, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutierrez A, Ortega FB, Ruiz JR, Artero EG, Romero VE, Pavon DJ, Chillon P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Consta O, Papadantonaki E, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagstromer M, Hallstrom L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlof AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sorensen S, Sanchez Molero J, Pico E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuan R, Lorente M, Sanchez MJ, Castello S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverken A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, Garcıa E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Borjesson I, Fernandez L, Smillie L, Wills J, Valtuena J, Jimenez Pavon D, Albers U, Pedrero R, Melendez A, Benito PJ, Lorente JJ, Canada D, Urzanqui A, Torres RM, Navarro P., VITAGLIONE, PAOLA, De Cocker, Katrien, Artero, Enrique G., De Henauw, Stefaan, Dietrich, Sabine, Gottrand, Frédéric, Béghin, Laurent, Hagströmer, Maria, Sjöström, Michael, Plada, Maria, Manios, Yanni, Mauro, Beatrice, Molnár, Déne, Moreno, Luis A., Ottevaere, Charlene, Valtueña, Jara, Maes, Lea, De Bourdeaudhuij, Ilse, Moreno, La, Gottrand, F, De Henauw, S, Gonzalez Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sanchez, J, Kersting, M, Sjostrom, M, Molnar, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Melendez, P, Fleta, J, Casajus, Ja, Rodrıguez, G, Tomas, C, Mesana, Mi, Vicente Rodrıguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lazaro, A, Bueno, O, Leon, Jf, Garagorri, Jm, Bueno, M, Lopez, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Warnberg, J, Nova, E, Gomez, S, Dıaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Torok, K, Bokor, S, Nagy, E, Kovacs, O, Repasi, J, Codrington, C, Plada, M, Angeliki, P, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutierrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavon, Dj, Chillon, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Galfo, M, Donne, Cl, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De, Vriendt, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Consta, O, Papadantonaki, E, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagstromer, M, Hallstrom, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlof, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sorensen, S, Sanchez Molero, J, Pico, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuan, R, Lorente, M, Sanchez, Mj, Castello, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverken, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, Garcıa, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Borjesson, I, Fernandez, L, Smillie, L, Wills, J, Valtuena, J, Jimenez Pavon, D, Albers, U, Pedrero, R, Melendez, A, Benito, Pj, Lorente, Jj, Canada, D, Urzanqui, A, Torres, Rm, and Navarro, P.

Subjects
Male, Adolescent, Cross-sectional study, Health Behavior, Psychological intervention, Medicine (miscellaneous), Intention, Socioeconomic Factor, Social class, Social support, Nutrition and Dietetic, Humans, Medicine, Social inequality, Child, Exercise, Life Style, Socioeconomic status, Cross-Sectional Studie, Self-efficacy, Nutrition and Dietetics, Family wealth, business.industry, Public Health, Environmental and Occupational Health, Awarene, Social Support, Awareness, Mediating effect, Self Efficacy, Adolescence, Social Cla, Europe, Cross-Sectional Studies, Social Class, Socioeconomic Factors, Female, Self Report, business, Psychosocial, Human, Demography
Abstract

ObjectiveSocio-economic status (SES) has been positively associated with physical activity (PA) levels in adolescents. In order to tackle these social inequalities, information is needed about the underlying mechanisms of this association. The present study aimed to investigate the potential mediating role of psychosocial correlates of PA on the relationship between SES and PA in European adolescents.DesignCross-sectional study testing the mediating role of psychosocial correlates in the SES–PA association using the product-of-coefficients test of MacKinnon.SettingTen European cities in nine different countries, the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study.SubjectsAdolescents (n 2780) aged 12·5–17·49 years self-reported on PA (moderate-to-vigorous intensity PA and total PA), SES indicators (education of the mother and Family Affluence Scale) and psychosocial correlates of PA (stage of change, attitudes, awareness, modelling, social support, self-efficacy, benefits, barriers and environmental correlates).ResultsSES (Family Affluence Scale) was significantly associated with moderate-to-vigorous intensity PA. According to single-mediator models, this association was significantly mediated by stage of change (t = 3·6, P ≤ 0·001), awareness (t = 2·7, 0·001 < P ≤ 0·01), modelling (t = 4·8, P ≤ 0·001), self-efficacy (t = 2·5, 0·01

Published
2012

46. Vitamin D status and physical activity interact to improve bone mass in adolescents. The HELENA Study

Author

Valtuena, J., Gracia Marco, L., Vicente Rodríguez, G., González Gross, M., Huybrechts, I., Rey López, J. P., Mouratidou, T., Sioen, I., Mesana, M. I., Díaz Martínez, A. E., Widhalm, K., Moreno, L. A., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sáchez J, Kesting M, Sjostrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Mouratidou T, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Kersting M, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, HurtigWennlöf A, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Gómez Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, Valtuena, J., Gracia Marco, L., Vicente Rodríguez, G., González Gross, M., Huybrechts, I., Rey López, J. P., Mouratidou, T., Sioen, I., Mesana, M. I., Díaz Martínez, A. E., Widhalm, K., Moreno, L. A., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sáchez, J, Kesting, M, Sjostrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Mouratidou, T, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Kersting, M, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Hurtigwennlöf, A, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Gómez Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Subjects
Male, musculoskeletal diseases, medicine.medical_specialty, Adolescent, Adolescent Nutritional Physiological Phenomena, Endocrinology, Diabetes and Metabolism, Physical fitness, Physical activity, chemistry.chemical_element, Motor Activity, Calcium, Bone and Bones, Absorptiometry, Photon, Bone Density, Risk Factors, Surveys and Questionnaires, Internal medicine, medicine, Vitamin D and neurology, Surveys and Questionnaire, Humans, Body Weights and Measures, Vitamin D, Bone, Child, Calcifediol, Cross-Sectional Studie, business.industry, Risk Factor, Body Weights and Measure, Physical fitne, Anthropometry, humanities, Cross-Sectional Studies, Endocrinology, chemistry, Body Composition, Lean body mass, Bone mineral content, Female, Season, Seasons, business, human activities, Bone and Bone, Human, Bone mass
Abstract

The effects of vitamin D concentrations on bone mineral content in adolescents are still unclear. Vitamin D and physical activity (PA) may interact to determine bone mineral content (BMC) in two possible directions; 25(OH)D sufficiency levels improve BMC only in active adolescents, or PA increases BMC in individuals with replete vitamin D levels. The effects of suboptimal 25-hydroxycholecalciferol (25(OH)D) concentrations on BMC in adolescents are still unclear. The main aim of this study was to evaluate the influence of 25(OH)D on BMC in adolescents, considering the effect of body composition, sex, age, Tanner stage, season, calcium and vitamin D intakes, physical fitness and PA. Serum 25(OH)D concentrations, anthropometric measurements, dual energy X-ray absorptiometry measurements, calcium and vitamin D intakes, PA and physical fitness were obtained in 100 Spanish adolescents (47 males), aged 12.5–17.5 years, within the framework of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. Relations were examined using ANCOVA and regression analyses including BMC as dependent variable. Linear regression of BMC suggested that 25(OH)D concentrations independently influenced total and leg BMC after controlling for age, sex, lean mass, seasonality and calcium intake (B = 0.328, p

Published
2012

47. Bone Mass and Bone Metabolism Markers during Adolescence: The HELENA Study

Author

Gracia Marco, L., Vicente Rodríguez, G., Valtueña, J., Rey López, J. P., Díaz Martínez, A. E., Mesana, M. I., Widhalm, K., Ruiz, J. R., González Gross, M., Castillo, M. J., Moreno, L. A., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Mae L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira J, Bueno G, Lázaro A, Bueno O, Léon JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marco LA, Marcos A, Wärnberg J, Nova E, Gómez S, Daíz EL, Romeo J, Veses A, Puergollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Garzón MJ, Sáinz AG, Porcel FB, Ruiz JR, Artero EG, Romero VE, Pavón DJ, Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrí L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallströöm L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Frederiksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Jiménez Pavón D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Gracia Marco, L., Vicente Rodríguez, G., Valtueña, J., Rey López, J. P., Díaz Martínez, A. E., Mesana, M. I., Widhalm, K., Ruiz, J. R., González Gross, M., Castillo, M. J., Moreno, L. A., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Mae, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, J, Bueno, G, Lázaro, A, Bueno, O, Léon, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marco, La, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Daíz, El, Romeo, J, Veses, A, Puergollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Garzón, Mj, Sáinz, Ag, Porcel, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavón, Dj, Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrí, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallströöm, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Frederiksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Jiménez Pavón, D, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Lorente, J. J.

Subjects
Male, musculoskeletal diseases, Aging, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Osteocalcin, chemistry.chemical_element, Growth, Calcium, Bone and Bones, Collagen Type I, Bone remodeling, Absorptiometry, Photon, Endocrinology, Internal medicine, medicine, Humans, Bone Resorption, Sex Characteristics, β-Isomerized C-telopeptide, Bone Development, Anthropometry, biology, business.industry, musculoskeletal, neural, and ocular physiology, Puberty, Biomarker, Organ Size, Sex Characteristic, musculoskeletal system, Calcium, Dietary, chemistry, Propeptide of type I procollagen, Pediatrics, Perinatology and Child Health, Body Composition, biology.protein, Bone mineral content, Female, business, Biomarkers, Bone and Bone, Human, Sex characteristics, Bone mass
Abstract

Background/Aims: The assessment of bone mineral content (BMC) and density (BMD) status in children and adolescents is important for health and the prevention of diseases. Bone metabolic activity could provide early information on bone mass development. Our aim was to describe bone mass and metabolism markers according to age and Tanner stage in adolescents. Methods: Spanish adolescents (n = 345; 168 males and 177 females) aged 12.5–17.5 years participated in this cross-sectional study. Body composition variables were measured by dual-energy X-ray absorptiometry. Serum osteocalcin (n = 101), aminoterminal propeptide of type I procollagen (n = 92) and β-isomerized C-telopeptides (β-CTX, n = 65) and urine samples (β-CTX; n = 237) were analyzed by electrochemiluminescence immunoassay. Results: Analysis of covariance showed that females had higher values for BMC and BMD in most of the regions. Both males and females had a significant decrease in bone markers while sexual maturation increases (all p < 0.05). Males had an increased bone turnover compared to females (all p < 0.05, except for urine β-CTX in Tanner ≤IV). Conclusion: Our results support the evidence of dimorphic site-specific bone accretion between sexes and show an increased bone turnover in males, suggesting higher metabolic activity.

Published
2010

48. Myrmecofauna (Hymenoptera: Formicidae) present in vineyards infested with Eurhizococcus brasiliensis(Hemiptera: Margarodidae) in southern Brazil

Author

NONDILLO, A., ARIOLI, C. J., WILD, A., BUENO, O. C., BOTTON, M., Aline Nondillo, Laboratório de Entomologia, Embrapa Uva e Vinho, 95.7000-000, Bento Gonçalves, Brazil, E-mail: odaircb@rc.unesp.br (O. C. B.), MARCOS BOTTON, CNPUV., E-mail: alinondillo@gmail.com.br (A. N.), E-mail: cristianoarioli@epagri.sc.gov.br (C. J. A.), Cristiano João Arioli, Empresa de Pesquisa Agropecuária e Extenção Rural de Santa Catarina, 89.560-000, Videira, Brazil, Alexander Wild, University of Texas, Austin, Texas 78666-4684, USA, E-mail: myrmecos.photo@gmail.com (A. W.), and Odair Correa Bueno, Instituto de Biociências, Centro de Estudos de Insetos Sociais, Universidade Estadual Paulista, 13.506-900, Rio Claro, Brazil

Subjects
Soil scale, Linepithema micans, Eurhizococcus Brasiliensis, Ant, FORMIGA, Survey
Abstract

Eurhizococcus brasiliensis (Wille) (Hemiptera: Margarodidae) is among the principal pests of Brazilian vineyards. Establishment and spread of this species in vineyards are associated with ants (Hymenoptera: Formicidae). This study determined the diversity of the ant fauna in E. brasiliensis infested vineyards in Rio Grande do Sul and Santa Catarina, the main grape-producing states in Brazil. Underground pitfall traps baited with a honey–water solution and sardines were used to sample ants in the spring–summer and fall–winter periods. Twenty-eight species of ants were identified in Rio Grande do Sul and 15 in Santa Catarina. Linepithema micans (Forel) (Hymenoptera: Formicidae) was the most requent and abundant species collected in vineyards in both states. Control strategies for ants associated with the spread of E. brasiliensis should focus on L. micans in vineyards. Key Words: survey; ant; soil scale; Linepithema micans A cochonilha de raízes pérola-da-terra Eurhizococcus brasiliensis (Wille) (Hemiptera: Margarodidae) é considerada uma das principais pragas da videira no Brasil. O estabelecimento e a dispersão da espécie nos parreirais estão associados à formigas (Hymenoptera: Formicidae). Neste trabalho, foi determinada a diversidade da fauna de formigas em parreirais infestados com a cochonilha nos Estados do Rio Grande do Sul e Santa Catarina, principais estados produtores de uva do Brasil. Armadilhas “pitfall” subterrâneas iscadas com solução aquosa de mel e sardinha foram colocadas no interior dos vinhedos entre os períodos da primavera/verão e outono/inverno. Vinte e oito espécies de formigas foram identificadas no Rio Grande do Sul e quinze em Santa Catarina. Linepithema micans (Forel) (Hymenoptera: Formicidae) foi a espécie com maior frequência e abundância nos parreirais amostrados em ambos estados amostrados. Estratégias de controle de formigas associadas à dispersão da pérola-da-terra devem ser direcionadas para esta espécie nos vinhedos. Palavras Chave: levantamento; formiga; cochonilha; Linepithema micans Made available in DSpace on 2017-12-05T23:17:08Z (GMT). No. of bitstreams: 1 024.100.03101.pdf: 474640 bytes, checksum: d587fb19d5998cd3d083aa17d095d43e (MD5) Previous issue date: 2017-12-04

Published
2017

49. Inflammation profile in overweight/obese adolescents in Europe: an analysis in relation to iron status

Author

Ferrari, M, Cuenca García, M., Valtueña, J., Moreno, L. A., Censi, L., González Gross, M., Androutsos, O., Gilbert, C. C., Huybrechts, I., Dallongeville, J., Sjöström, M., Molnar, D., De Henauw, S., Gómez Martínez, S., De Moraes, A. C. F., Kafatos, A., Widhalm, K., Leclercq, C., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sáchez J, Kesting M, Sjostrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Aurora Lázaro, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Kersting M, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Picker P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Cuenca Garcia M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Thomas S, Allchurch E, Burgess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Gómez Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, European Commission, Ministerio de Educación (España), Universidad Politécnica de Madrid, Sao Paulo Research Foundation, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ferrari, M, Cuenca García, M., Valtueña, J., Moreno, L. A., Censi, L., González Gross, M., Androutsos, O., Gilbert, C. C., Huybrechts, I., Dallongeville, J., Sjöström, M., Molnar, D., De Henauw, S., Gómez Martínez, S., De Moraes, A. C. F., Kafatos, A., Widhalm, K., Leclercq, C., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sáchez, J, Kesting, M, Sjostrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Aurora, Lázaro, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Kersting, M, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Picker, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Cuenca Garcia, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Galfo, M, Donne, Cl, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Gómez Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Subjects
Male, Cross-sectional study, Medicine (miscellaneous), Sex Factor, Overweight, Body Mass Index, Nutrition and Dietetic, Adiposity, Nutrition and Dietetics, biology, Anemia, Iron-Deficiency, Medicine (all), Transferrin, Iron Deficiencies, Orosomucoid, Europe, Nutritional Statu, C-Reactive Protein, Adipose Tissue, Female, Iron status, Dietary Proteins, medicine.symptom, Human, medicine.medical_specialty, Adolescent, Iron, Nutritional Status, Inflammation, Sex Factors, Internal medicine, Environmental health, medicine, Humans, Obesity, Cross-Sectional Studie, Ferritin, business.industry, Dietary Protein, C-reactive protein, nutritional and metabolic diseases, Biomarker, Anthropometry, medicine.disease, Diet, Endocrinology, Cross-Sectional Studies, Ferritins, biology.protein, business, Body mass index, Biomarkers
Abstract

On behalf of the HELENA Study Group., [Background/Objectives]: The objectives of this study were to investigate the relationship between inflammatory parameters (CRP, c-reactive protein; AGP, α1-acid glycoprotein), iron status indicators (SF, serum ferritin; sTfR, soluble transferrin receptor) and body mass index (BMI) z-score, fat-free mass (FFM) and fat mass (FM) in European adolescents. Differences in intake for some nutrients (total iron, haem and non-haem iron, vitamin C, calcium, proteins) were assessed according to BMI categories, and the association of nutrient intakes with BMI z-score, FM and FFM was evaluated., [Methods]: A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample., [Results]: Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7±0.3 and 1.4±0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1±0.2 and 1.0±0.1 mg/l in boys and girls, respectively) (P, [Conclusions]: The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency., The HELENA Study has taken place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005–007034). Additional support was obtained from the Spanish Ministry of Education (AGL2007-29784-E/ALI; AP-2005-3827; AP-2008-03806). Jara Valtueña was financially supported by the Universidad Politécnica de Madrid. Augusto César F. de Moraes was given scholarship from São Paulo Research Foundation – FAPESP (proc. 2011/11137-1 and 2011/20662-2). Luis A. Moreno was given scholarship of visiting professor from Brazilian government by Science without Borders Program by CNPq (National Counsel of Technological and Scientific Development) and CAPES (Coordination of Improvement of Higher Education Personnel) (proc. 007/2012).

Published
2015

50. Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents—the HELENA study

Author

Pérez de Heredia, Fátima, Gómez Martínez, Sonia, Díaz, Ligia Esperanza, Veses, Ana M., Nova, Esther, Wärnberg, Julia, Huybrechts, Inge, Vyncke, Krishna, Androutsos, Odysseas, Ferrari, Marika, Palacios, Gonzalo, Wastlund, Acki, Kovács, Éva, Gottrand, Frédéric, González Gross, Marcela, Castillo, Manuel J., Sjöstrom, Michael, Manios, Yannis, Kafatos, Anthony, Molnár, Denes, Widhalm, Kurt, Moreno, Luis A., Marcos, Ascensión, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Castelló S, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Gracia Marco LA, Mouratidou T, Marcos A, Nova E, Gómez Martínez S, Díaz LE, Romeo J, Veses A, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Roccaldo R, VITAGLIONE, PAOLA, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Hagströmer M, Hurtig Wennlöf A, Hallström L, Patterson E, Kwak L, Wärnberg J, Rizzo N, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Thomas S, Allchurch E, Burgess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Palacios G, Meléndez A, Benito PJ, Gómez Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., Pérez de Heredia, Fátima, Gómez Martínez, Sonia, Díaz, Ligia Esperanza, Veses, Ana M., Nova, Esther, Wärnberg, Julia, Huybrechts, Inge, Vyncke, Krishna, Androutsos, Odyssea, Ferrari, Marika, Palacios, Gonzalo, Wastlund, Acki, Kovács, Éva, Gottrand, Frédéric, González Gross, Marcela, Castillo, Manuel J., Sjöstrom, Michael, Manios, Yanni, Kafatos, Anthony, Molnár, Dene, Widhalm, Kurt, Moreno, Luis A., Marcos, Ascensión, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Castelló, S, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Gracia Marco, La, Mouratidou, T, Marcos, A, Nova, E, Gómez Martínez, S, Díaz, Le, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Roccaldo, R, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Hagströmer, M, Hurtig Wennlöf, A, Hallström, L, Patterson, E, Kwak, L, Wärnberg, J, Rizzo, N, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Palacios, G, Meléndez, A, Benito, Pj, Gómez Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Subjects
Male, medicine.medical_specialty, Adolescent, Neutrophils, RJ, Lymphocyte, RJ101, chemical and pharmacologic phenomena, Basophil, CD16, Adolescents, Monocytes, Immunophenotyping, Leukocyte Count, Sex Factors, Reference Values, immune system diseases, Internal medicine, White blood cell, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, hemic and lymphatic diseases, Leukocytes, medicine, Humans, Cytotoxic T cell, Lymphocytes, Sexual Maturation, 10. No inequality, Body mass index, 2. Zero hunger, Immune cell, business.industry, Immune cells, Puberty, Age Factors, hemic and immune systems, Basophils, 3. Good health, Eosinophils, Endocrinology, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Female, Sex, business, CD8, circulatory and respiratory physiology
Abstract

© 2015, Springer-Verlag Berlin Heidelberg. Percentiles 10th, 25th, 50th, 75th and 90th are presented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5–17.5 years, n = 405, 48.9 % boys), considering age, sex, puberty and body mass index (BMI). CD3+ (mature T cells), CD4+ (T helper), CD8+ (T cytotoxic), CD16+56+ (natural killer), CD19+ (B cells), CD3+CD45RA+, CD4+CD45RA+, CD8+CD45RA+ (naïve), CD3+CD45RO+, CD4+CD45RO+ and CD8+CD45RO+ (memory) lymphocytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3+CD45RO+ and CD4+CD45RO+ cell counts and CD3+/CD19+ ratio, and lower CD3+CD45RA+ and CD4+CD45RA+ counts than boys. Age was associated with higher neutrophil counts and CD3+/CD19+, and lower CD19+ counts; in boys, with lower CD3+CD45RA+, CD4+CD45RA+ and CD8+CD45RA+ counts as well; in girls, with higher WBC, CD3+CD45RO+ and CD4+CD45RO+ counts. Pubertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher basophil, CD3+CD45RO+ and CD4+CD45RO+ values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4+, CD3+CD45RO+ and CD4+CD45RO+ counts. Conclusion: Our study provides normative values for circulating immune cells in adolescents, highlighting the importance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations., As well as the financial support of the European Community 6th RTD Framework Programme (contract FOOD-CT-2005-007034)

Published
2015

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