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5. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

Author

Blanchard-Rohner, Geraldine, Sanchez, Carlos, Andre, Maya C., Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia A., Trück, Johannes, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Severi Conti, Alessia, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L’Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Lütolf Erni, Michaela, Kaiser, Daniela, Schwendener Scholl, Katharina, Peter Kuen, Hans, Hrup, Katja, Stritt, Janine, Bailey, Douggl G. N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Pachlopnik Schmid, Jana, Seiler, Michelle, Meyer Sauteur, Patrick, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.

Published
2024
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6. Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial

Author

Andre, Maya C., Sanchez, Carlos, Bressieux-Degueldre, Sabrina, Perez, Marie-Helene, Wütz, Daniela, Blanchard-Rohner, Geraldine, Grazioli, Serge, Schöbi, Nina, Trück, Johannes, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Conti, Alessia Severi, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L'Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Erni, Michaela Lütolf, Kaiser, Daniela, Scholl, Katharina Schwendener, Kuen, Hans Peter, Hrup, Katja, Stritt, Janine, Bailey, Douggl G.N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Schmid, Jana Pachlopnik, Seiler, Michelle, Sauteur, Patrick Meyer, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.

Published
2024
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10. Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use.

Author

Dao, Kim, Buettcher, Michael, Golhen, Klervi, Kost, Jonas, Schittny, Andreas, Duthaler, Urs, Atkinson, Andrew, Haefliger, David, Guidi, Monia, Bardinet, Carine, Chtioui, Haithem, Boulekbache, Abdelwahab, Buclin, Thierry, Huwyler, Jörg, Pfister, Marc, and Rothuizen, Laura E.

Subjects
*RESEARCH funding, *PHARMACEUTICAL chemistry, *TASTE, *PARASITIC diseases, *STATISTICAL sampling, *ORAL drug administration, *RANDOMIZED controlled trials, *DESCRIPTIVE statistics, *CROSSOVER trials, *BIOAVAILABILITY, *CONFIDENCE intervals, *ANTIPARASITIC agents, *ANTHELMINTICS, *CHILDREN
Abstract

Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, the only available oral formulation is tablets designed for adult patients. A patient‐friendly orodispersible tablet formulation designed for pediatric use (CHILD‐IVITAB) has been developed and is entering early phase clinical trials. To inform the pediatric program of CHILD‐IVITAB, 16 healthy adults were enrolled in a phase I, single‐center, open‐label, randomized, 2‐period, crossover, single‐dose trial which aimed to compare palatability, tolerability, and bioavailability and pharmacokinetics of CHILD‐IVITAB and their variability against the marketed ivermectin tablets (STROMECTOL) at a single dose of 12 mg in a fasting state. Palatability with CHILD‐IVITAB was considerably enhanced as compared to STROMECTOL. Both ivermectin formulations were well tolerated and safe. Relative bioavailability of CHILD‐IVITAB compared to STROMECTOL was estimated as the ratios of geometric means for Cmax, AUC 0‐∞, and AUC0‐last, which were 1.52 [90% CI: 1.13‐2.04], 1.27 [0.99‐1.62], and 1.29 [1.00‐1.66], respectively. Maximum drug concentrations occurred earlier with the CHILD‐IVITAB formulation, with a median Tmax at 3.0 h [range 2.0‐4.0 h] versus 4.0 h [range 2.0‐5.0 h] with STROMECTOL (P =.004). With CHILD‐IVITAB, variability in exposure was cut in half (coefficient of variation: 37% vs 70%) compared to STROMECTOL. Consistent with a more controlled absorption process, CHILD‐IVITAB was associated with reduced variability in drug exposure as compared to STROMECTOL. Together with a favorable palatability and tolerability profile, these findings motivate for further clinical studies to evaluate benefits of such a patient‐friendly ODT formulation in pediatric patients with a parasitic disease, including infants and young children <15 kg. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg.

Author

Golhen, Klervi, Buettcher, Michael, Huwyler, Jörg, van den Anker, John, Gotta, Verena, Dao, Kim, Rothuizen, Laura E., Kobylinski, Kevin, and Pfister, Marc

Subjects
*DRUG delivery systems, *IVERMECTIN, *ADULTS, *ABSORPTION
Abstract

The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15 kg. Simulations were performed to identify dosing with CHILD-IVITAB associated with similar exposure coverage in children ≥ 15 kg and < 15 kg as observed in adults receiving the reference formulation STROMECTOL®. A total of 448 ivermectin concentrations were available from 16 healthy adults. The absorption rate constant was 2.41 h−1 (CV 19%) for CHILD-IVITAB vs. 1.56 h−1 (CV 43%) for STROMECTOL®. Simulations indicated that 250 µg/kg of CHILD-IVITAB is associated with exposure coverage in children < 15 kg consistent with that observed in children ≥ 15 kg and adults receiving 200 µg/kg of STROMECTOL®. Performed analysis confirmed that CHILD-IVITAB is associated with faster and more controlled absorption than STROMECTOL®. Simulations indicate that 250 µg/kg of CHILD-IVITAB achieves equivalent ivermectin exposure coverage in children < 15 kg as seen in children ≥ 15 kg and adults. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Mycoplasma pneumoniae:delayed re-emergence after COVID-19 pandemic restrictions

Author

Meyer Sauteur, Patrick M., Beeton, Michael L., Pereyre, Sabine, Bébéar, Cécile, Gardette, Marie, Hénin, Nadège, Wagner, Noémie, Fischer, Adrien, Vitale, Alessandra, Lemaire, Baptiste, Greub, Gilbert, Brouillet, René, Zimmermann, Petra, Agyeman, Philipp KA, Aebi, Christoph, Buettcher, Michael, Hostettler, Marisa, Kottanattu, Lisa, Gaia, Valeria, Imkamp, Frank, Egli, Adrian, Berger, Christoph, Sidorov, Semjon, Osuna, Ester, Tilen, Romy, Niederer-Loher, Anita, Dollenmaier, Günter, Barbey, Florence, Heininger, Ulrich, Goldenberger, Daniel, Ivan, Branislav, Keller, Peter M., Papan, Cihan, Becker, Sören L., Forster, Johannes, MacKenzie, Colin R., Henrich, Birgit, Vermeulen, Melissa, Bossuyt, Nathalie, Matheeussen, Veerle, van Westreenen, Mireille, Vogel, Marius, van Rossum, Annemarie MC, Afshar, Baharak, Cottrell, Simon, Moore, Catherine, Uldum, Søren Anker, Emborg, Hanne Dorthe, Gullsby, Karolina, Laine, Miia, Meyer Sauteur, Patrick M., Beeton, Michael L., Pereyre, Sabine, Bébéar, Cécile, Gardette, Marie, Hénin, Nadège, Wagner, Noémie, Fischer, Adrien, Vitale, Alessandra, Lemaire, Baptiste, Greub, Gilbert, Brouillet, René, Zimmermann, Petra, Agyeman, Philipp KA, Aebi, Christoph, Buettcher, Michael, Hostettler, Marisa, Kottanattu, Lisa, Gaia, Valeria, Imkamp, Frank, Egli, Adrian, Berger, Christoph, Sidorov, Semjon, Osuna, Ester, Tilen, Romy, Niederer-Loher, Anita, Dollenmaier, Günter, Barbey, Florence, Heininger, Ulrich, Goldenberger, Daniel, Ivan, Branislav, Keller, Peter M., Papan, Cihan, Becker, Sören L., Forster, Johannes, MacKenzie, Colin R., Henrich, Birgit, Vermeulen, Melissa, Bossuyt, Nathalie, Matheeussen, Veerle, van Westreenen, Mireille, Vogel, Marius, van Rossum, Annemarie MC, Afshar, Baharak, Cottrell, Simon, Moore, Catherine, Uldum, Søren Anker, Emborg, Hanne Dorthe, Gullsby, Karolina, and Laine, Miia

Published
2024

13. Tularemia on the rise in Switzerland? A one health approach is needed!

Author

Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Albini, Sarah; https://orcid.org/0000-0002-9498-0243, Altpeter, Ekkehardt; https://orcid.org/0000-0001-9881-8801, Labutin, Anton; https://orcid.org/0000-0002-5706-2822, Guidi, Valeria; https://orcid.org/0000-0001-5553-3136, Tonolla, Mauro; https://orcid.org/0000-0002-8861-7763, Lienhard, Reto; https://orcid.org/0000-0003-3310-989X, Opota, Onya; https://orcid.org/0000-0002-5421-0607, Schmid, Patrizia, Wuethrich, Tsering, Schmidt, Kristina M, TULAR-CH working group, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Albini, Sarah; https://orcid.org/0000-0002-9498-0243, Altpeter, Ekkehardt; https://orcid.org/0000-0001-9881-8801, Labutin, Anton; https://orcid.org/0000-0002-5706-2822, Guidi, Valeria; https://orcid.org/0000-0001-5553-3136, Tonolla, Mauro; https://orcid.org/0000-0002-8861-7763, Lienhard, Reto; https://orcid.org/0000-0003-3310-989X, Opota, Onya; https://orcid.org/0000-0002-5421-0607, Schmid, Patrizia, Wuethrich, Tsering, Schmidt, Kristina M, and TULAR-CH working group

Abstract

In the last 10 years, an increase in tularemia cases has been observed in both humans and animals in Switzerland. In these, infection with Francisella tularensis, the causative agent of the zoonotic disease tularemia, can occur through arthropod vectors or contact to infected animals or exposure to contaminated environmental sources. Currently, we are only able to postulate potential aetiologies: (i) behavioral changes of humans with more exposure to endemic habitats of infected arthropod vectors; (ii) an increased rate of tularemia infected ticks; (iii) increasing number and geographical regions of tick biotopes; (iv) increasing and/or more diverse reservoir populations; (v) increasing presence of bacteria in the environment; (vi) raised awareness and increased testing among physicians; (vii) improved laboratory techniques including molecular testing. To approach these questions, a one-health strategy is necessary. A functioning collaboration between public health, human medicine, and diagnostic and veterinary units for the control of tularemia must be established. Furthermore, the public should be included within citizen-supported-science-projects.

Published
2024

14. Swiss consensus recommendations on urinary tract infections in children

Author

Buettcher, Michael, Trueck, Johannes, Niederer-Loher, Anita, Heininger, Ulrich, Agyeman, Philipp, Asner, Sandra, Berger, Christoph, Bielicki, Julia, Kahlert, Christian, Kottanattu, Lisa, Meyer Sauteur, Patrick M., Paioni, Paolo, Posfay-Barbe, Klara, Relly, Christa, Ritz, Nicole, Zimmermann, Petra, Zucol, Franziska, Gobet, Rita, Shavit, Sandra, Rudin, Christoph, Laube, Guido, von Vigier, Rodo, and Neuhaus, Thomas J.

Published
2021
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15. Pneumonia outbreaks due to re-emergence of Mycoplasma pneumoniae

Author

Meyer Sauteur, Patrick M, primary, Beeton, Michael L, additional, Pereyre, Sabine, additional, Bébéar, Cécile, additional, Gardette, Marie, additional, Hénin, Nadège, additional, Wagner, Noémie, additional, Fischer, Adrien, additional, Vitale, Alessandra, additional, Lemaire, Baptiste, additional, Greub, Gilbert, additional, Brouillet, René, additional, Opota, Onya, additional, Zimmermann, Petra, additional, Agyeman, Philipp K A, additional, Aebi, Christoph, additional, Buettcher, Michael, additional, Hostettler, Marisa, additional, Kottanattu, Lisa, additional, Gaia, Valeria, additional, Imkamp, Frank, additional, Egli, Adrian, additional, Berger, Christoph, additional, Sidorov, Semjon, additional, Osuna, Ester, additional, Tilen, Romy, additional, Niederer-Loher, Anita, additional, Dollenmaier, Günter, additional, Barbey, Florence, additional, Heininger, Ulrich, additional, Goldenberger, Daniel, additional, Ivan, Branislav, additional, Keller, Peter M, additional, Papan, Cihan, additional, Becker, Sören L, additional, Forster, Johannes, additional, MacKenzie, Colin R, additional, Henrich, Birgit, additional, Vermeulen, Melissa, additional, Bossuyt, Nathalie, additional, Matheeussen, Veerle, additional, van Westreenen, Mireille, additional, Vogel, Marius, additional, van Rossum, Annemarie MC, additional, Afshar, Baharak, additional, Cottrell, Simon, additional, Moore, Catherine, additional, Uldum, Søren Anker, additional, Emborg, Hanne-Dorthe, additional, Gullsby, Karolina, additional, Laine, Miia, additional, Peltola, Ville, additional, Heinonen, Santtu, additional, Døllner, Henrik, additional, Width, Frode Gran, additional, Christensen, Andreas, additional, Buonsenso, Danilo, additional, Rodrigues, Fernanda Maria Pereira, additional, Rodrigues, Jorge, additional, Tsantila, Katerina, additional, Matsas, Minos, additional, Kalogera, Eleni, additional, Petridou, Evangelia, additional, Kopsidas, Ioannis, additional, Keše, Darja, additional, Nir-Paz, Ran, additional, Elinav, Hila, additional, Michael-Gayego, Ayelet, additional, Oishi, Tomohiro, additional, Saraya, Takeshi, additional, Kenri, Tsuyoshi, additional, Wang, Pei, additional, Shen, Adong, additional, Cao, Bin, additional, Hsieh, Yu-Chia, additional, Wu, Tsung-Hua, additional, Maiwald, Matthias, additional, Loo, Liat Hui, additional, Sagar, Tanu, additional, Chaudhry, Rama, additional, Kociolek, Larry K, additional, Kies, Kami D, additional, Mainella, Jill, additional, Kapinos, Jessica, additional, Patel, Robin, additional, Rodríguez, Nadia, additional, Lorenz, David, additional, and Blakiston, Matthew R, additional

Published
2024
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17. Correction to: Swiss consensus recommendations on urinary tract infections in children

Author

Buettcher, Michael, Trueck, Johannes, Niederer-Loher, Anita, Heininger, Ulrich, Agyeman, Philipp, Asner, Sandra, Berger, Christoph, Bielicki, Julia, Kahlert, Christian, Kottanattu, Lisa, Meyer Sauteur, Patrick M., Paioni, Paolo, Posfay-Barbe, Klara, Relly, Christa, Ritz, Nicole, Zimmermann, Petra, Zucol, Franziska, Gobet, Rita, Shavit, Sandra, Rudin, Christoph, Laube, Guido, von Vigier, Rodo, and Neuhaus, Thomas J.

Published
2021
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18. Ongoing disruption of RSV epidemiology in children in Switzerland

Author

Meyer Sauteur, Patrick M., Aebi, Christoph, Barbey, Florence, Berger, Christoph, Bielicki, Julia A., Buettcher, Michael, Catho, Gaud, Croxatto, Antony, Deubzer-Raunhardt, Beate, Dumoulin, Alexis, Gebauer, Mathias U., Grimm, Mirjam, Heininger, Ulrich, Kahlert, Christian R., Kellner, Eva, Kottanattu, Lisa, Kawkby, Jasr, Laube, Guido F., Niederer-Loher, Anita, Plebani, Margherita, Posfay-Barbe, Klara M., Ritz, Nicole, Spigariol, Fabian, Trück, Johannes, Wagner, Noémie, Zimmermann, Petra, Zucol, Franziska, and Agyeman, Philipp K.A.

Published
2024
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19. The changing clinical presentation of COVID‐19 in children during the course of the pandemic.

Author

Wurm, Juliane, Uka, Anita, Bernet, Vera, Buettcher, Michael, Giannoni, Eric, Kottanattu, Lisa, Schöbi, Nina, Zemmouri, Abdelaziz, Ritz, Nicole, Zimmermann, Petra, Barbey, Florence, Cachat, François, Dülli, Livia, Fluri, Simon, Gebauer, Mathias, Grupe, Silke, Jochumsen, Ulla, Kellner, Eva, Kerr, Ute, and Laube, Guido

Subjects
COVID-19 pandemic, SYMPTOMS, SARS-CoV-2, SCHOOL children, SARS-CoV-2 Omicron variant
Abstract

Aim: To investigate the evolution of clinical symptoms of COVID‐19 in children throughout the pandemic. Methods: In this national prospective surveillance study, symptoms in children hospitalised with COVID‐19 were collected from all paediatric hospitals in Switzerland between March 2020 and March 2023. Data was analysed across four time periods, according to the predominantly circulating SARS‐CoV‐2 variant: T1 (wild‐type), T2 (Alpha), T3 (Delta) and T4 (Omicron), as well as by age group. Results: The study included 1323 children. The proportion of children admitted to an intensive care unit remained stable throughout the pandemic. However, the pattern and frequency of clinical manifestations changed over time. Respiratory symptoms were less prevalent during T1 (wild‐type), fever during T2 (Alpha) and rash during T4 (Omicron). In contrast, fever and neurological symptoms were more prevalent during T4 (Omicron). Newly described symptoms during T4 (Omicron) included conjunctivitis, laryngotracheitis and seizures. Fever was more prevalent among neonates and infants whereas respiratory symptoms were more common among infants. Gastrointestinal symptoms were more frequent among toddlers, while both toddlers and school‐aged children presented with neurological symptoms more often than other age groups. Conclusion: Continuous surveillance is required to detect changes in manifestations and there by be prepared for the optimal management of complications in children with COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions

Author

Meyer Sauteur, Patrick M, primary, Beeton, Michael L, additional, Pereyre, Sabine, additional, Bébéar, Cécile, additional, Gardette, Marie, additional, Hénin, Nadège, additional, Wagner, Noémie, additional, Fischer, Adrien, additional, Vitale, Alessandra, additional, Lemaire, Baptiste, additional, Greub, Gilbert, additional, Brouillet, René, additional, Zimmermann, Petra, additional, Agyeman, Philipp KA, additional, Aebi, Christoph, additional, Buettcher, Michael, additional, Hostettler, Marisa, additional, Kottanattu, Lisa, additional, Gaia, Valeria, additional, Imkamp, Frank, additional, Egli, Adrian, additional, Berger, Christoph, additional, Sidorov, Semjon, additional, Osuna, Ester, additional, Tilen, Romy, additional, Niederer-Loher, Anita, additional, Dollenmaier, Günter, additional, Barbey, Florence, additional, Heininger, Ulrich, additional, Goldenberger, Daniel, additional, Ivan, Branislav, additional, Keller, Peter M, additional, Papan, Cihan, additional, Becker, Sören L, additional, Forster, Johannes, additional, MacKenzie, Colin R, additional, Henrich, Birgit, additional, Vermeulen, Melissa, additional, Bossuyt, Nathalie, additional, Matheeussen, Veerle, additional, van Westreenen, Mireille, additional, Vogel, Marius, additional, van Rossum, Annemarie MC, additional, Afshar, Baharak, additional, Cottrell, Simon, additional, Moore, Catherine, additional, Uldum, Søren Anker, additional, Emborg, Hanne-Dorthe, additional, Gullsby, Karolina, additional, Laine, Miia, additional, Peltola, Ville, additional, Heinonen, Santtu, additional, Døllner, Henrik, additional, Width, Frode Gran, additional, Christensen, Andreas, additional, Buonsenso, Danilo, additional, Pereira Rodrigues, Fernanda Maria, additional, Rodrigues, Jorge, additional, Tsantila, Katerina, additional, Matsas, Minos, additional, Kalogera, Eleni, additional, Petridou, Evangelia, additional, Kopsidas, Ioannis, additional, Keše, Darja, additional, Nir-Paz, Ran, additional, Elinav, Hila, additional, Michael-Gayego, Ayelet, additional, Oishi, Tomohiro, additional, Saraya, Takeshi, additional, Kenri, Tsuyoshi, additional, Hsieh, Yu-Chia, additional, Wu, Tsung-Hua, additional, Maiwald, Matthias, additional, Loo, Liat Hui, additional, Sagar, Tanu, additional, Chaudhry, Rama, additional, Kociolek, Larry K, additional, Kies, Kami D, additional, Mainella, Jill, additional, Kapinos, Jessica, additional, Patel, Robin, additional, Rodríguez, Nadia, additional, Lorenz, David, additional, and Blakiston, Matthew R, additional

Published
2023
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22. Cardiac involvement in children with paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): data from a prospective nationwide surveillance study

Author

Uka, Anita, primary, Bressieux-Degueldre, Sabrina, additional, Buettcher, Michael, additional, Kottanattu, Lisa, additional, Plebani, Margerita, additional, Niederer-Loher, Anita, additional, Schöbi, Nina, additional, Hofer, Michael, additional, Tomasini, Julie, additional, Trück, Johannes, additional, Villiger, Reto, additional, Wagner, Noémie, additional, Wuetz, Daniela, additional, Ritz, Nicole, additional, and Zimmermann, Petra, additional

Published
2023
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24. Mycoplasma pneumoniae: gone forever?

Author

Meyer Sauteur, Patrick M, primary, Beeton, Michael L, additional, Pereyre, Sabine, additional, Bébéar, Cécile, additional, Gardette, Marie, additional, Hénin, Nadège, additional, Wagner, Noémie, additional, Fischer, Adrien, additional, Vitale, Alessandra, additional, Kessler, Julie, additional, Andreutti, Corinne, additional, Greub, Gilbert, additional, Zimmermann, Petra, additional, Agyeman, Philipp K A, additional, Aebi, Christoph, additional, Buettcher, Michael, additional, Hostettler, Marisa, additional, Kottanattu, Lisa, additional, Gaia, Valeria, additional, Imkamp, Frank, additional, Egli, Adrian, additional, Berger, Christoph, additional, Sidorov, Semjon, additional, Tilen, Romy, additional, Niederer-Loher, Anita, additional, Barbey, Florence, additional, Heininger, Ulrich, additional, Ivan, Branislav, additional, Papan, Cihan, additional, Becker, Sören L, additional, Forster, Johannes, additional, Kohns Vasconcelos, Malte, additional, Henrich, Birgit, additional, MacKenzie, Colin R, additional, Bossuyt, Nathalie, additional, Vermeulen, Melissa, additional, Matheeussen, Veerle, additional, van Westreenen, Mireille, additional, Verkaik, Nelianne J, additional, Vogel, Marius, additional, van Rossum, Annemarie M C, additional, Afshar, Baharak, additional, Uldum, Søren Anker, additional, Emborg, Hanne-Dorthe, additional, Gullsby, Karolina, additional, Laine, Miia, additional, Peltola, Ville, additional, Heinonen, Santtu, additional, Døllner, Henrik, additional, Width, Frode Gran, additional, Christensen, Andreas, additional, Buonsenso, Danilo, additional, Rodrigues, Fernanda M P, additional, Rodrigues, Jorge, additional, Tsantila, Katerina, additional, Matsas, Minos, additional, Kalogera, Eleni, additional, Petridou, Evangelia, additional, Kopsidas, Ioannis, additional, Keše, Darja, additional, Nir-Paz, Ran, additional, Elinav, Hila, additional, Michael-Gayego, Ayelet, additional, Oishi, Tomohiro, additional, Saraya, Takeshi, additional, Hsieh, Yu-Chia, additional, Wu, Tsung Hua, additional, Maiwald, Matthias, additional, Loo, Liat Hui, additional, Sagar, Tanu, additional, Chaudhry, Rama, additional, Kociolek, Larry K, additional, Rodríguez, Nadia, additional, Lorenz, David, additional, and Blakiston, Matthew R, additional

Published
2023
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27. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial

Author

Welzel, Tatjana, primary, Atkinson, Andrew, additional, Schöbi, Nina, additional, Andre, Maya C, additional, Bailey, Douggl G N, additional, Blanchard-Rohner, Geraldine, additional, Buettcher, Michael, additional, Grazioli, Serge, additional, Koehler, Henrik, additional, Perez, Marie-Helene, additional, Trück, Johannes, additional, Vanoni, Federica, additional, Zimmermann, Petra, additional, Sanchez, Carlos, additional, Bielicki, Julia A, additional, Schlapbach, Luregn J, additional, Bieri, Andreas, additional, Gysi, Spyridoula, additional, Janz, Indra, additional, Donner, Birgit, additional, Hammer, Jürg, additional, Heininger, Ulrich, additional, Kohns Vasconcelos, Malte, additional, Mettauer, Nicole, additional, Meyer, Alexandra, additional, Reppucci, Diana, additional, Schlaeppi, Chloé, additional, Trachsel, Daniel, additional, Vaezipour, Nina, additional, von Kalckreuth, Clemens, additional, Woerner, Andreas, additional, Zutter, Andreas, additional, Kottanattu, Lisa, additional, Mazzara, Calogero, additional, Severi Conti, Alessia, additional, Aebi, Christoph, additional, Agyeman, Philipp K A, additional, Duppenthaler, Andrea, additional, Glöckler, Martin, additional, Pallivathukal, Sabine, additional, Riedel, Thomas, additional, Cudré-Cung, Hong-Phuc, additional, Pavlovic, Mladen, additional, Bordessoule, Alice, additional, L'Huillier, Arnaud G, additional, Martin, Anne-Laure, additional, Polito, Angelo, additional, Rohr, Marie, additional, Rodriguez, Maria Isabel, additional, Wagner, Noemie, additional, Chanez, Vivianne, additional, Bressieux-Degueldre, Sabrina, additional, Ferry, Thomas, additional, Hofer, Michael, additional, Longchamp, David, additional, Natterer, Julia, additional, Oppenheim, Rebecca, additional, Donas, Alex, additional, Germann, Sara, additional, Hrup, Katja, additional, Kaiser, Daniela, additional, Kuen, Hans Peter, additional, Lütolf Erni, Michaela, additional, Schwendener Scholl, Katharina, additional, Stritt, Janine, additional, Wechselberger, Katharina, additional, Beck, Ingrid, additional, Birkenmaier, André, additional, Flade, Martin, additional, Rogdo, Bjarte, additional, Iglowstein, Ivo, additional, Lorenz, Philip, additional, Wachinger, Tanja, additional, Zöhrer, Konstanze, additional, Brotschi, Barbara, additional, Meyer Sauteur, Patrick M, additional, Pachlopnik Schmid, Jana, additional, Prader, Seraina, additional, Seiler, Michelle, additional, Weber, Kathrin, additional, Wütz, Daniela, additional, Whittaker, Elizabeth, additional, and Faust, Saul N, additional

Published
2023
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29. Vaccine Hesitancy in Central Switzerland: Identifying and Characterizing Undervaccinated Children in a Pediatric Emergency Department

Author

Ménétrey, Anika, Landolt, Markus A; https://orcid.org/0000-0003-0760-5558, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Neuhaus, Thomas J, Simma, Leopold; https://orcid.org/0000-0003-3032-2759, Ménétrey, Anika, Landolt, Markus A; https://orcid.org/0000-0003-0760-5558, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Neuhaus, Thomas J, and Simma, Leopold; https://orcid.org/0000-0003-3032-2759

Published
2023

30. Cardiac involvement in children with paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): data from a prospective nationwide surveillance study

Author

Uka, Anita, Bressieux-Degueldre, Sabrina, Buettcher, Michael, Kottanattu, Lisa, Plebani, Margerita, Niederer-Loher, Anita, Schöbi, Nina, Hofer, Michael, Tomasini, Julie, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Villiger, Reto, Wagner, Noémie, Wuetz, Daniela, Ritz, Nicole, Zimmermann, Petra, Uka, Anita, Bressieux-Degueldre, Sabrina, Buettcher, Michael, Kottanattu, Lisa, Plebani, Margerita, Niederer-Loher, Anita, Schöbi, Nina, Hofer, Michael, Tomasini, Julie, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Villiger, Reto, Wagner, Noémie, Wuetz, Daniela, Ritz, Nicole, and Zimmermann, Petra

Abstract

BACKGROUND Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) may occur 4 to 8 weeks after SARS-CoV-2 infection. The acute presentation of PIMS-TS has been well described, but data on longer-term outcomes, particularly cardiac, is scarce. METHODS This prospective nationwide surveillance study included children and adolescents less than 18 years of age who were hospitalised with PIMS-TS in Switzerland between March 2020 and March 2022. Data was collected from all 29 paediatric hospitals through the Swiss Paediatric Surveillance Unit (SPSU) during hospitalisation and approximately six weeks after discharge. The data was analysed after categorising the participants into three groups based on their admission status to the intensive care unit (ICU) (non-ICU, ICU-moderate) and the requirement for invasive ventilatory and/or inotropic support (ICU-severe). RESULTS Overall, 204 children were included of whom 194 (95.1%) had follow-up data recorded. Median age was 9.0 years (interquartile range [IQR] 6.0-11.5) and 142 (69.6%) were male. In total, 105/204 (51.5%) required ICU admission, of whom 55/105 (52.4%) received inotropic support and 14/105 (13.3%) mechanical ventilation (ICU-severe group). Echocardiography was performed in 201/204 (98.5%) children; 132 (64.7%) had a cardiac abnormality including left ventricular systolic dysfunction (73 [36.3%]), a coronary artery abnormality (45 [22.4%]), pericardial effusion (50 [24.9%]) and mitral valve regurgitation (60 [29.9%]). Left ventricular systolic dysfunction was present at admission in 62/201 (30.8%) children and appeared during hospitalisation in 11 (5.5%) children. A coronary artery abnormality was detected at admission in 29/201 (14.2%) children and developed during hospitalisation or at follow-up in 13 (6.5%) and 3 (1.5%) children, respectively. None of the children had left ventricular systolic dysfunction at follow-up, but a coronary abnormality and pericardial effusion were

Published
2023

31. Mycoplasma pneumoniae beyond the COVID-19 pandemic: where is it?

Author

Sauteur, Patrick M Meyer, primary, Chalker, Victoria J, additional, Berger, Christoph, additional, Nir-Paz, Ran, additional, Beeton, Michael L, additional, Pereyre, Sabine, additional, Bébéar, Cécile, additional, Wagner, Noémie, additional, Andreutti, Corinne, additional, Greub, Gilbert, additional, Agyeman, Philipp K A, additional, Aebi, Christoph, additional, Buettcher, Michael, additional, Kottanattu, Lisa, additional, Gaia, Valeria, additional, Imkamp, Frank, additional, Zbinden, Reinhard, additional, Sidorov, Semjon, additional, Niederer-Loher, Anita, additional, Barbey, Florence, additional, Egli, Adrian, additional, Heininger, Ulrich, additional, Schlaeppi, Chloé, additional, Papan, Cihan, additional, Kohns Vasconcelos, Malte, additional, Henrich, Birgit, additional, Mackenzie, Colin, additional, Dumke, Roger, additional, Schneider, Gerlinde, additional, Bossuyt, Nathalie, additional, Vermeulen, Melissa, additional, Loens, Katherine, additional, van Westreenen, Mireille, additional, Verkaik, Nelianne J, additional, van Rossum, Annemarie M C, additional, Day, Jessica, additional, Afshar, Baharak, additional, Peltola, Ville, additional, Heinonen, Santtu, additional, Renko, Marjo, additional, Tapiainen, Terhi, additional, Døllner, Henrik, additional, Rodrigues, Fernanda, additional, Matsas, Minos, additional, Kalogera, Eleni, additional, Petridou, Evangelia, additional, Kopsidas, Ioannis, additional, Zaoutis, Theoklis E, additional, Keše, Darja, additional, Elinav, Hila, additional, Michael-Gayego, Ayelet, additional, Namkoong, Ho, additional, Hsieh, Yu-Chia, additional, Maiwald, Matthias, additional, Loo, Liat Hui, additional, Chaudhry, Rama, additional, Kociolek, Larry K, additional, Rodríguez, Nadia, additional, Lorenz, David, additional, and Blakiston, Matthew, additional

Published
2022
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32. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial

Author

Welzel, Tatjana, Atkinson, Andrew, Schöbi, Nina, Andre, Maya C, Bailey, Douggl G N, Blanchard-Rohner, Geraldine, Buettcher, Michael, Grazioli, Serge, Koehler, Henrik, Perez, Marie-Helene, Trück, Johannes, Vanoni, Federica, Zimmermann, Petra, Sanchez, Carlos, Bielicki, Julia A, Schlapbach, Luregn J, and University of Zurich

Subjects
Coronavirus, Zurich, MISC, 10036 Medical Clinic, own, 610 Medicine & health, 610 Medizin und Gesundheit, RCT, COVID, PIMS
Abstract

BACKGROUND The emergence of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) led to the widespread use of anti-inflammatory treatments in the absence of evidence from randomised controlled trials (RCTs). We aimed to assess the effectiveness of intravenous methylprednisolone compared with intravenous immunoglobulins. METHODS This is an open-label, multicentre, two-arm RCT done at ten hospitals in Switzerland in children younger than 18 years hospitalised with PIMS-TS (defined as age

Published
2023
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35. Prise en charge mdicale des rfugis mineurs d039Ukraine

Author

Jger, Fabienne N., primary, Berger, Christoph, additional, Buettcher, Michael, additional, Depallens, Sarah, additional, Heininger, Ulrich, additional, Heller, Yvon, additional, Kohns Vasconcelos, Malte, additional, Leforestier, Bodil, additional, Pellaud, Nicole, additional, Relly, Christa, additional, Trck, Johannes, additional, von Overbeck Ottino, Saskia, additional, Bernhard-Stirnemann, Sara, additional, Wagner, Nomie, additional, and Ritz, Nicole, additional

Published
2022
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36. Junge Flchtlinge optimal versorgen

Author

Jger, Fabienne N., primary, Berger, Christoph, additional, Buettcher, Michael, additional, Depallens, Sarah, additional, Heininger, Ulrich, additional, Heller, Yvon, additional, Kohns Vasconcelos, Malte, additional, Leforestier, Bodil, additional, Pellaud, Nicole, additional, Relly, Christa, additional, Trck, Johannes, additional, von Overbeck Ottino, Saskia, additional, Bernhard-Stirnemann, Sara, additional, Wagner, Nomie, additional, and Ritz, Nicole, additional

Published
2022
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37. Pneumonia outbreaks due to re-emergence of Mycoplasma pneumoniae

Author

Pereyre, Sabine, Bébéar, Cécile, Gardette, Marie, Hénin, Nadège, Wagner, Noémie, Fischer, Adrien, Vitale, Alessandra, Lemaire, Baptiste, Greub, Gilbert, Brouillet, René, Opota, Onya, Zimmermann, Petra, Agyeman, Philipp K A, Aebi, Christoph, Buettcher, Michael, Hostettler, Marisa, Kottanattu, Lisa, Gaia, Valeria, Imkamp, Frank, Egli, Adrian, Berger, Christoph, Sidorov, Semjon, Osuna, Ester, Tilen, Romy, Niederer-Loher, Anita, Dollenmaier, Günter, Barbey, Florence, Heininger, Ulrich, Goldenberger, Daniel, Ivan, Branislav, Keller, Peter M, Papan, Cihan, Becker, Sören L, Forster, Johannes, MacKenzie, Colin R, Henrich, Birgit, Vermeulen, Melissa, Bossuyt, Nathalie, Matheeussen, Veerle, van Westreenen, Mireille, Vogel, Marius, van Rossum, Annemarie MC, Afshar, Baharak, Cottrell, Simon, Moore, Catherine, Uldum, Søren Anker, Emborg, Hanne-Dorthe, Gullsby, Karolina, Laine, Miia, Peltola, Ville, Heinonen, Santtu, Døllner, Henrik, Width, Frode Gran, Christensen, Andreas, Buonsenso, Danilo, Rodrigues, Fernanda Maria Pereira, Rodrigues, Jorge, Tsantila, Katerina, Matsas, Minos, Kalogera, Eleni, Petridou, Evangelia, Kopsidas, Ioannis, Keše, Darja, Nir-Paz, Ran, Elinav, Hila, Michael-Gayego, Ayelet, Oishi, Tomohiro, Saraya, Takeshi, Kenri, Tsuyoshi, Wang, Pei, Shen, Adong, Cao, Bin, Hsieh, Yu-Chia, Wu, Tsung-Hua, Maiwald, Matthias, Loo, Liat Hui, Sagar, Tanu, Chaudhry, Rama, Kociolek, Larry K, Kies, Kami D, Mainella, Jill, Kapinos, Jessica, Patel, Robin, Rodríguez, Nadia, Lorenz, David, Blakiston, Matthew R, Meyer Sauteur, Patrick M, and Beeton, Michael L

Published
2024
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38. Multicenter Randomized Trial of Methylprednisolone vs. Intravenous Immunoglobulins to Treat the Pediatric Inflammatory Multisystem Syndrome—Temporally Associated With SARS-CoV-2 (PIMS-TS): Protocol of the Swissped RECOVERY Trial

Author

Welzel, Tatjana, Schöbi, Nina, André, Maya C., Bailey, Douggl G. N., Blanchard-Rohner, Geraldine, Buettcher, Michael, Grazioli, Serge, Koehler, Henrik, Perez, Marie-Helene, Trück, Johannes, Vanoni, Federica, Zimmermann, Petra, Atkinson, Andrew, Sanchez, Carlos, Whittaker, Elizabeth, Faust, Saul N., Bielicki, Julia A., and Schlapbach, Luregn J.

Subjects
hemic and lymphatic diseases, Pediatrics, Perinatology and Child Health, 610 Medicine & health
Abstract

IntroductionIn 2020, a new disease entitled Pediatric Inflammatory Multisystem Syndrome temporally associated with COVID-19 (PIMS-TS), or Multisystem Inflammatory Syndrome in Children (MIS-C), emerged, with thousands of children affected globally. There is no available evidence based on randomized controlled trials (RCT) to date on the two most commonly used immunomodulatory treatments, intravenous immunoglobulins (IVIG) and corticosteroids. Therefore, the Swissped RECOVERY trial was conducted to assess whether intravenous (IV) methylprednisolone shortens hospital length of stay compared with IVIG.Methods and AnalysisSwissped RECOVERY is an ongoing investigator-initiated, open-label, multicenter two-arm RCT in children and adolescents SignificanceCurrently, robust trial evidence for the treatment of PIMS-TS is lacking, with a controversy surrounding the use of corticosteroids vs. IVIG. This trial will provide evidence for the effectiveness and safety of these two treatments.Ethics and DisseminationThe study protocol, which was designed based on the U.K. RECOVERY trial, the patient information and consent forms, and other study-specific study documents were approved by the local ethics committees (Project ID: 2021-00362).Registration DetailsThe study is registered on the Swiss National Clinical Trials Portal (SNCTP000004720) and Clinicaltrials.gov (NCT 04826588).

Published
2022
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39. Understanding efficacy-safety balance of biologics in moderate-to-severe pediatric psoriasis

Author

Golhen, Klervi, Winskill, Carolyn, Theiler, Martin; https://orcid.org/0000-0001-7160-3958, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Yeh, Yu-Hsin, Zhang, Nancy, Welzel, Tatjana, Pfister, Marc, Golhen, Klervi, Winskill, Carolyn, Theiler, Martin; https://orcid.org/0000-0001-7160-3958, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Yeh, Yu-Hsin, Zhang, Nancy, Welzel, Tatjana, and Pfister, Marc

Abstract

BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory skin disease affecting both adults and children. To better understand the efficacy-safety profile of biologics in children with moderate-to-severe psoriasis, this study aimed to analyze efficacy and safety data of randomized controlled trials (RCTs) performed in pediatric psoriasis and to compare efficacy outcomes in children with those in adults. METHODS: RCTs investigating biologics in children with moderate-to-severe psoriasis were identified in a systematic literature review. PASI75/90 treatment responses at weeks 11/12 were analyzed comparing biologics with control arms. Serious adverse events (SAEs) were analyzed at the end of each study. Efficacy data from RCTs in adults with psoriasis were selected for the same biologics. Risk ratios (RR) of selected RCTs were pooled together in a statistical random effects model using the inverse variance method. RESULTS: For children, there were 1 etanercept, 2 secukinumab, 1 ixekizumab and 1 ustekinumab placebo-controlled RCTs and 1 adalimumab RCT using methotrexate as reference arm at weeks 11/12. For adults, out of 263 RCTs, 7 adalimumab and 15 etanercept (TNF inhibitors) and 4 ixekizumab and 12 ustekinumab (IL-17 and IL-12/23 inhibitors) RCTs reported PASI75/90 efficacy responses at weeks 11/12. Regarding efficacy, all biologics showed improved PASI responses over control arms. RRs ranges were 2.02-7.45 in PASI75 and 4.10-14.50 in PASI90. The highest PASI75 responses were seen for ustekinumab 0.375 mg/kg (RR = 7.25, 95% CI 2.83-18.58) and ustekinumab 0.75 mg/kg (RR = 7.45, 95% CI 2.91-19.06) in the CADMUS study. The highest PASI90 response was seen for ixekizumab (RR = 14.50, 95% CI 4.82-43.58) in the IXORA-PEDS study. SAE incidences in pediatric and adult arms with biologics were 0 to 3% except for a pediatric arm with adalimumab 0.40 mg/kg (8%). For adults, pooled RR also showed improved PASI responses over placebo for all biologics, with highest PASI75

Published
2022

40. The kinetic profiles of copeptin and mid regional proadrenomedullin (MR-proADM) in pediatric lower respiratory tract infections

Author

Baumann, Philipp; https://orcid.org/0000-0002-1244-8131, Fuchs, Aline, Gotta, Verena, Ritz, Nicole, Baer, Gurli, Bonhoeffer, Jessica M, Buettcher, Michael, Heininger, Ulrich, Szinnai, Gabor, Bonhoeffer, Jan, Baumann, Philipp; https://orcid.org/0000-0002-1244-8131, Fuchs, Aline, Gotta, Verena, Ritz, Nicole, Baer, Gurli, Bonhoeffer, Jessica M, Buettcher, Michael, Heininger, Ulrich, Szinnai, Gabor, and Bonhoeffer, Jan

Abstract

BACKGROUND Kinetics of copeptin and mid regional proadrenomedullin (MR-proADM) during febrile pediatric lower respiratory tract infections (LRTI) are unknown. We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical and laboratory factors on those biomarkers. METHODS This is a retrospective post-hoc analysis of a randomized controlled trial, evaluating procalcitonin guidance for antibiotic treatment of LRTI (ProPAED-study). In 175 pediatric patients presenting to the emergency department plasma copeptin and MR-proADM concentrations were determined on day 1, 3, and 5. Their association with clinical characteristics and other inflammatory biomarkers were tested by non-linear mixed effect modelling. RESULTS Median copeptin and MR-proADM values were elevated on day 1 and decreased during on day 3 and 5 (-26%; -34%, respectively). The initial concentrations of MR-proADM at inclusion were higher in patients receiving antibiotics intravenously compared to oral administration (difference 0.62 pmol/L, 95%CI 0.44;1.42, p<0.001). Intensive care unit (ICU) admission was associated with a daily increase of MR-proADM (increase/day 1.03 pmol/L, 95%CI 0.43;1.50, p<0.001). Positive blood culture in patients with antibiotic treatment and negative results on nasopharyngeal aspirates, or negative blood culture were associated with a decreasing MR-proADM (decrease/day -0.85 pmol/L, 95%CI -0.45;-1.44), p<0.001). CONCLUSION Elevated MR-proADM and increases thereof were associated with ICU admission suggesting the potential as a prognostic factor for severe pediatric LRTI. MR-proADM might only bear limited value for decision making on stopping antibiotics due to its slow decrease. Copeptin had no added value in our setting.

Published
2022

41. Hospital outcomes of community-acquired COVID-19 versus influenza: Insights from the Swiss hospital-based surveillance of influenza and COVID-19

Author

Fröhlich, Georg Marcus, De Kraker, Marlieke E A, Abbas, Mohamed, Keiser, Olivia, Thiabaud, Amaury, Roelens, Maroussia, Cusini, Alexia, Flury, Domenica, Schreiber, Peter W, Buettcher, Michael, Corti, Natascia, Vuichard-Gysin, Danielle, Troillet, Nicolas, Sauser, Julien, Gaudenz, Roman, Damonti, Lauro, Balmelli, Carlo, Iten, Anne, Widmer, Andreas, Harbarth, Stephan, Sommerstein, Rami, Fröhlich, Georg Marcus, De Kraker, Marlieke E A, Abbas, Mohamed, Keiser, Olivia, Thiabaud, Amaury, Roelens, Maroussia, Cusini, Alexia, Flury, Domenica, Schreiber, Peter W, Buettcher, Michael, Corti, Natascia, Vuichard-Gysin, Danielle, Troillet, Nicolas, Sauser, Julien, Gaudenz, Roman, Damonti, Lauro, Balmelli, Carlo, Iten, Anne, Widmer, Andreas, Harbarth, Stephan, and Sommerstein, Rami

Abstract

BackgroundSince the onset of the COVID-19 pandemic, the disease has frequently been compared with seasonal influenza, but this comparison is based on little empirical data.AimThis study compares in-hospital outcomes for patients with community-acquired COVID-19 and patients with community-acquired influenza in Switzerland.MethodsThis retrospective multi-centre cohort study includes patients > 18 years admitted for COVID-19 or influenza A/B infection determined by RT-PCR. Primary and secondary outcomes were in-hospital mortality and intensive care unit (ICU) admission for patients with COVID-19 or influenza. We used Cox regression (cause-specific and Fine-Gray subdistribution hazard models) to account for time-dependency and competing events with inverse probability weighting to adjust for confounders.ResultsIn 2020, 2,843 patients with COVID-19 from 14 centres were included. Between 2018 and 2020, 1,381 patients with influenza from seven centres were included; 1,722 (61%) of the patients with COVID-19 and 666 (48%) of the patients with influenza were male (p < 0.001). The patients with COVID-19 were younger (median 67 years; interquartile range (IQR): 54-78) than the patients with influenza (median 74 years; IQR: 61-84) (p < 0.001). A larger percentage of patients with COVID-19 (12.8%) than patients with influenza (4.4%) died in hospital (p < 0.001). The final adjusted subdistribution hazard ratio for mortality was 3.01 (95% CI: 2.22-4.09; p < 0.001) for COVID-19 compared with influenza and 2.44 (95% CI: 2.00-3.00, p < 0.001) for ICU admission.ConclusionCommunity-acquired COVID-19 was associated with worse outcomes compared with community-acquired influenza, as the hazards of ICU admission and in-hospital death were about two-fold to three-fold higher.

Published
2022

42. Paediatric refugees from Ukraine: guidance for health care providers

Author

Jaeger, Fabienne N; https://orcid.org/0000-0002-8441-3907, Berger, Christoph; https://orcid.org/0000-0002-2373-8804, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Depallens, Sarah; https://orcid.org/0000-0002-7074-1985, Heininger, Ulrich; https://orcid.org/0000-0001-8901-6778, Heller, Yvon, Kohns Vasconcelos, Malte; https://orcid.org/0000-0002-6207-9442, Leforestier, Bodil, Pellaud, Nicole; https://orcid.org/0000-0001-8561-7146, Relly, Christa, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, von Overbeck Ottino, Saskia; https://orcid.org/0000-0001-9235-7602, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Ritz, Nicole; https://orcid.org/0000-0002-1498-1685, Jaeger, Fabienne N; https://orcid.org/0000-0002-8441-3907, Berger, Christoph; https://orcid.org/0000-0002-2373-8804, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Depallens, Sarah; https://orcid.org/0000-0002-7074-1985, Heininger, Ulrich; https://orcid.org/0000-0001-8901-6778, Heller, Yvon, Kohns Vasconcelos, Malte; https://orcid.org/0000-0002-6207-9442, Leforestier, Bodil, Pellaud, Nicole; https://orcid.org/0000-0001-8561-7146, Relly, Christa, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, von Overbeck Ottino, Saskia; https://orcid.org/0000-0001-9235-7602, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, and Ritz, Nicole; https://orcid.org/0000-0002-1498-1685

Abstract

BACKGROUND: With the invasion of Ukraine by the Russian Army in February 2022, refugees, the majority of whom are women and children, started fleeing the war to neighbouring countries. Even before the current escalation, the conflict in the eastern part of Ukraine has led to the internal displacement of more than 200,000 children, and many others have experienced attacks, e.g. on schools. This inevitably leads to limitations in health care delivery. During transit, overcrowding, poor shelter and vulnerability may further put refugees at increased risk for infectious diseases. This consensus document aims to provide information and guidance regarding health issues that paediatricians and general practitioners may face when caring for Ukrainian children. METHODS: Members of the Migrant Health Reference Group of Paediatrics Switzerland and the Paediatric Infectious Disease Group in Switzerland developed this recommendation between March and April 2022 in a modified Delphi process. RESULTS: A total of 50 recommendations were agreed on with a ≥80% consensus. These include the following topics: i) general aspects, including interpreter services, urgent health needs, personal history and general check-ups; ii) mental health, including how to search for signs of psychological distress without going into traumatic details; iii) vaccinations, including recommendations for evaluation and catch-up; iv) screening for tuberculosis, human immunodeficiency virus, and hepatitis B and C; and v) providing age-appropriate preventive and health service information. CONCLUSION: This document provides current evidence and guidance when caring for paediatric refugees from Ukraine. The recommendations focus on Switzerland but may well be used in other countries. These are based on current evidence and may need to be adapted to individual situations and once further evidence becomes available.

Published
2022

43. Swiss recommendations on perioperative antimicrobial prophylaxis in children

Author

Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi, Christoph; https://orcid.org/0000-0003-3554-7949, Bielicki, Julia; https://orcid.org/0000-0002-3902-5489, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, Berger, Christoph; https://orcid.org/0000-0002-2373-8804, Paioni, Paolo; https://orcid.org/0000-0002-3904-1606, Aebi, Christoph; https://orcid.org/0000-0003-3554-7949, Bielicki, Julia; https://orcid.org/0000-0002-3902-5489, Buettcher, Michael; https://orcid.org/0000-0001-6086-6162, Crisinel, Pierre Alex; https://orcid.org/0000-0002-1967-8255, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Wagner, Noémie; https://orcid.org/0000-0001-9133-9752, and Berger, Christoph; https://orcid.org/0000-0002-2373-8804

Abstract

Infection following surgical procedures leads to significant morbidity and mortality in all age groups. Sterile techniques, antibiotic prophylaxis and improved postoperative wound care have contributed to the decline of surgical site infections since the early days of surgery. Recommendations on the use of perioperative antimicrobial prophylaxis exist for adults, but are rare for the paediatric population. Here, we provide a standardised approach to the effective use of antimicrobial agents for the prevention of surgical site infections in children contributing to a targeted and rational perioperative use of antibiotics in Switzerland.

Published
2022

44. Paediatric refugees from Ukraine: guidance for health care providers

Author

Jaeger, Fabienne N., primary, Berger, Christoph, additional, Buettcher, Michael, additional, Depallens, Sarah, additional, Heininger, Ulrich, additional, Heller, Yvon, additional, Kohns Vasconcelos, Malte, additional, Leforestier, Bodil, additional, Pellaud, Nicole, additional, Relly, Christa, additional, Trück, Johannes, additional, Von Overbeck Ottino, Saskia, additional, Wagner, Noémie, additional, and Ritz, Nicole, additional

Published
2022
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46. Swiss recommendations on perioperative antimicrobial prophylaxis in children

Author

Paioni, Paolo, Aebi, Christoph, Bielicki, Julia, Buettcher, Michael, Crisinel, Pierre Alex, Kahlert, Christian R, Wagner, Noémie, Berger, Christoph, Paediatric Infectious Disease Group of Switzerland (PIGS), and University of Zurich

Subjects
History, Sociology and Political Science, General Mathematics, 610 Medicine & health, 2700 General Medicine, Anti-Bacterial Agents/therapeutic use, Anti-Infective Agents/therapeutic use, Antibiotic Prophylaxis/methods, Child, Humans, Surgical Wound Infection/epidemiology, Surgical Wound Infection/prevention & control, Switzerland, Anti-Infective Agents, Surgical Wound Infection, General Materials Science, General Environmental Science, Planning and Development, Multidisciplinary, Geography, Communication, Econometrics and Finance, Mechanical Engineering, General Medicine, General Chemistry, Antibiotic Prophylaxis, General Economics, Anti-Bacterial Agents, 10036 Medical Clinic, Political Science and International Relations, General Earth and Planetary Sciences
Abstract

Infection following surgical procedures leads to significant morbidity and mortality in all age groups. Sterile techniques, antibiotic prophylaxis and improved postoperative wound care have contributed to the decline of surgical site infections since the early days of surgery. Recommendations on the use of perioperative antimicrobial prophylaxis exist for adults, but are rare for the paediatric population. Here, we provide a standardised approach to the effective use of antimicrobial agents for the prevention of surgical site infections in children contributing to a targeted and rational perioperative use of antibiotics in Switzerland.

Published
2022
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48. Hospital outcomes of community-acquired COVID-19 versus influenza: Insights from the Swiss hospital-based surveillance of influenza and COVID-19

Author

Fröhlich, Georg Marcus, primary, De Kraker, Marlieke E. A., additional, Abbas, Mohamed, additional, Keiser, Olivia, additional, Thiabaud, Amaury, additional, Roelens, Maroussia, additional, Cusini, Alexia, additional, Flury, Domenica, additional, Schreiber, Peter W., additional, Buettcher, Michael, additional, Corti, Natascia, additional, Vuichard-Gysin, Danielle, additional, Troillet, Nicolas, additional, Sauser, Julien, additional, Gaudenz, Roman, additional, Damonti, Lauro, additional, Balmelli, Carlo, additional, Iten, Anne, additional, Widmer, Andreas, additional, Harbarth, Stephan, additional, and Sommerstein, Rami, additional

Published
2022
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49. Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions

Author

Pereyre, Sabine, Bébéar, Cécile, Gardette, Marie, Hénin, Nadège, Wagner, Noémie, Fischer, Adrien, Vitale, Alessandra, Lemaire, Baptiste, Greub, Gilbert, Brouillet, René, Zimmermann, Petra, Agyeman, Philipp KA, Aebi, Christoph, Buettcher, Michael, Hostettler, Marisa, Kottanattu, Lisa, Gaia, Valeria, Imkamp, Frank, Egli, Adrian, Berger, Christoph, Sidorov, Semjon, Osuna, Ester, Tilen, Romy, Niederer-Loher, Anita, Dollenmaier, Günter, Barbey, Florence, Heininger, Ulrich, Goldenberger, Daniel, Ivan, Branislav, Keller, Peter M, Papan, Cihan, Becker, Sören L, Forster, Johannes, MacKenzie, Colin R, Henrich, Birgit, Vermeulen, Melissa, Bossuyt, Nathalie, Matheeussen, Veerle, van Westreenen, Mireille, Vogel, Marius, van Rossum, Annemarie MC, Afshar, Baharak, Cottrell, Simon, Moore, Catherine, Uldum, Søren Anker, Emborg, Hanne-Dorthe, Gullsby, Karolina, Laine, Miia, Peltola, Ville, Heinonen, Santtu, Døllner, Henrik, Width, Frode Gran, Christensen, Andreas, Buonsenso, Danilo, Pereira Rodrigues, Fernanda Maria, Rodrigues, Jorge, Tsantila, Katerina, Matsas, Minos, Kalogera, Eleni, Petridou, Evangelia, Kopsidas, Ioannis, Keše, Darja, Nir-Paz, Ran, Elinav, Hila, Michael-Gayego, Ayelet, Oishi, Tomohiro, Saraya, Takeshi, Kenri, Tsuyoshi, Hsieh, Yu-Chia, Wu, Tsung-Hua, Maiwald, Matthias, Loo, Liat Hui, Sagar, Tanu, Chaudhry, Rama, Kociolek, Larry K, Kies, Kami D, Mainella, Jill, Kapinos, Jessica, Patel, Robin, Rodríguez, Nadia, Lorenz, David, Blakiston, Matthew R, Meyer Sauteur, Patrick M, and Beeton, Michael L

Published
2024
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