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1. Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults

Author

Harker-Murray, Paul, Mauz-Körholz, Christine, Leblanc, Thierry, Mascarin, Maurizio, Michel, Gérard, Cooper, Stacy, Beishuizen, Auke, Leger, Kasey J., Amoroso, Loredana, Buffardi, Salvatore, Rigaud, Charlotte, Hoppe, Bradford S., Lisano, Julie, Francis, Stephen, Sacchi, Mariana, Cole, Peter D., Drachtman, Richard A., Kelly, Kara M., and Daw, Stephen

Published
2023
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2. FDG PET in response evaluation of bulky masses in paediatric Hodgkin’s lymphoma (HL) patients enrolled in the Italian AIEOP-LH2004 trial

Author

Lopci, Egesta, Mascarin, Maurizio, Piccardo, Arnoldo, Castello, Angelo, Elia, Caterina, Guerra, Luca, Borsatti, Eugenio, Sala, Alessandra, Todesco, Alessandra, Zucchetta, Pietro, Farruggia, Piero, Cistaro, Angelina, Buffardi, Salvatore, Bertolini, Patrizia, Bianchi, Maurizio, Moleti, Maria Luisa, Bunkheila, Feisal, Indolfi, Paolo, Fagioli, Franca, Garaventa, Alberto, Burnelli, Roberta, and AIEOP Hodgkin Lymphoma Study Group, Italy

Published
2019
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3. The prognostic value of biological markers in paediatric Hodgkin lymphoma

Author

Cesaro, Simone, Zaccaron, Ada, Bertolini, Patrizia, Consarino, Caterina, Iaria, Grazia, Pericoli, Roberta, Pierani, Paolo, Fedeli, Fausto, Cellini, Monica, De Santis, Raffaela, Porta, Fulvio, Caini, Mauro, Cosmi, Carlo, Mirra, Nadia, Civino, Adele, Sperlì, Domenico, Nespoli, Luigi, Caniglia, Maurizio, Perruccio, Katia, D'Angelo, Paolo, Passone, Eva, Caruso, Roberta, Scarzello, Giovanni, Rondelli, Roberto, Farruggia, Piero, Puccio, Giuseppe, Sala, Alessandra, Todesco, Alessandra, Buffardi, Salvatore, Garaventa, Alberto, Bottigliero, Gaetano, Bianchi, Maurizio, Zecca, Marco, Locatelli, Franco, Pession, Andrea, Pillon, Marta, Favre, Claudio, D'Amico, Salvatore, Provenzi, Massimo, Trizzino, Angela, Zanazzo, Giulio Andrea, Sau, Antonella, Santoro, Nicola, Murgia, Giulio, Casini, Tommaso, Mascarin, Maurizio, and Burnelli, Roberta

Published
2016
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4. Nivolumab, Brentuximab Vedotin, +/- Bendamustine For R/R Hodgkin Lymphoma in Children, Adolescents, and Young Adults

Author

Harker-Murray, Paul, primary, Mauz-Körholz, Christine, additional, Leblanc, Thierry M, additional, Mascarin, Maurizio, additional, Michel, Gérard, additional, Cooper, Stacy, additional, Beishuizen, Auke, additional, Leger, Kasey J., additional, Amoroso, Loredana, additional, Buffardi, Salvatore, additional, Rigaud, Charlotte, additional, Hoppe, Bradford S., additional, Lisano, Julie M, additional, Francis, Stephen, additional, Sacchi, Mariana, additional, Cole, Peter D., additional, Drachtman, Richard A., additional, Kelly, Kara M., additional, and Daw, Stephen, additional

Published
2022
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5. Prospective Evaluation of Different Methods for Volumetric Analysis on [18F]FDG PET/CT in Pediatric Hodgkin Lymphoma

Author

Lopci, Egesta, primary, Elia, Caterina, additional, Catalfamo, Barbara, additional, Burnelli, Roberta, additional, De Re, Valli, additional, Mussolin, Lara, additional, Piccardo, Arnoldo, additional, Cistaro, Angelina, additional, Borsatti, Eugenio, additional, Zucchetta, Pietro, additional, Bianchi, Maurizio, additional, Buffardi, Salvatore, additional, Farruggia, Piero, additional, Garaventa, Alberto, additional, Sala, Alessandra, additional, Vinti, Luciana, additional, Mauz-Koerholz, Christine, additional, and Mascarin, Maurizio, additional

Published
2022
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6. Quantitative Plasma Proteomics to Identify Candidate Biomarkers of Relapse in Pediatric/Adolescent Hodgkin Lymphoma

Author

Repetto, Ombretta, primary, Caggiari, Laura, additional, De Zorzi, Mariangela, additional, Elia, Caterina, additional, Mussolin, Lara, additional, Buffardi, Salvatore, additional, Pillon, Marta, additional, Muggeo, Paola, additional, Casini, Tommaso, additional, Steffan, Agostino, additional, Mauz-Körholz, Christine, additional, Mascarin, Maurizio, additional, and De Re, Valli, additional

Published
2022
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7. Phosphoproteomic Analysis Reveals a Different Proteomic Profile in Pediatric Patients With T-Cell Lymphoblastic Lymphoma or T-Cell Acute Lymphoblastic Leukemia

Author

Veltri, Giulia, primary, Lovisa, Federica, additional, Cortese, Giuliana, additional, Pillon, Marta, additional, Carraro, Elisa, additional, Cesaro, Simone, additional, Provenzi, Massimo, additional, Buffardi, Salvatore, additional, Francescato, Samuela, additional, Biffi, Alessandra, additional, Buldini, Barbara, additional, Conter, Valentino, additional, Serafin, Valentina, additional, and Mussolin, Lara, additional

Published
2022
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8. Brentuximab vedotin in the treatment of paediatric patients with relapsed or refractory Hodgkin's lymphoma: Results of a real‐life study

Author

Massano, Davide, primary, Carraro, Elisa, additional, Mussolin, Lara, additional, Buffardi, Salvatore, additional, Barat, Veronica, additional, Zama, Daniele, additional, Muggeo, Paola, additional, Vendemini, Francesca, additional, Sau, Antonella, additional, Moleti, Maria Luisa, additional, Verzegnassi, Federico, additional, D'Amico, Salvatore, additional, Casini, Tommaso, additional, Garaventa, Alberto, additional, Schiavello, Elisabetta, additional, Cellini, Monica, additional, Vinti, Luciana, additional, Farruggia, Piero, additional, Perruccio, Katia, additional, Cesaro, Simone, additional, De Santis, Raffaela, additional, Marinoni, Maddalena, additional, D'Alba, Irene, additional, Mura, Rosa Maria, additional, Burnelli, Roberta, additional, Mascarin, Maurizio, additional, and Pillon, Marta, additional

Published
2022
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9. Outcome of Children and Adolescents with Recurrent Classical Hodgkin Lymphoma: The Italian Experience

Author

Garaventa, Alberto, primary, Parodi, Stefano, additional, Guerrini, Giulia, additional, Farruggia, Piero, additional, Sala, Alessandra, additional, Pillon, Marta, additional, Buffardi, Salvatore, additional, Rossi, Francesca, additional, Bianchi, Maurizio, additional, Zecca, Marco, additional, Vinti, Luciana, additional, Facchini, Elena, additional, Casini, Tommaso, additional, Bernasconi, Sayla, additional, Amoroso, Loredana, additional, D’Amico, Salvatore, additional, Provenzi, Massimo, additional, De Santis, Raffaela, additional, Sau, Antonella, additional, Muggeo, Paola, additional, Mura, Rosa Maria, additional, Haupt, Riccardo, additional, Mascarin, Maurizio, additional, and Burnelli, Roberta, additional

Published
2022
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10. Brentuximab vedotin in combination with bendamustine in pediatric patients or young adults with relapsed or refractory Hodgkin lymphoma

Author

Vinti, Luciana, primary, Pagliara, Daria, additional, Buffardi, Salvatore, additional, Di Ruscio, Valentina, additional, Stocchi, Francesca, additional, Mariggiò, Elena, additional, Parasole, Rosanna, additional, De Matteo, Antonia, additional, Petruzziello, Fara, additional, Paganelli, Valeria, additional, De Vito, Rita, additional, Del Bufalo, Francesca, additional, Strocchio, Luisa, additional, and Locatelli, Franco, additional

Published
2022
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11. Non-Hodgkin Lymphoma in Children With an Associated Inherited Condition: A Retrospective Analysis of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)

Author

Aricò, Maurizio, Mussolin, Lara, Carraro, Elisa, Buffardi, Salvatore, Santoro, Nicola, DʼAngelo, Paolo, Lombardi, Alessandra, Pierani, Paolo, Giraldi, Eugenia, Mura, Rossella, Sala, Alessandra, Garaventa, Alberto, Tondo, Annalisa, Piglione, Matilde, Lo Nigro, Luca, Cesaro, Simone, Perruccio, Katia, Rosolen, Angelo, Basso, Giuseppe, and Pillon, Marta

Published
2015
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12. Long-term results of the AIEOP LNH-97 protocol for childhood lymphoblastic lymphoma

Author

Pillon, Marta, Aricò, Maurizio, Mussolin, Lara, Carraro, Elisa, Conter, Valentino, Sala, Alessandra, Buffardi, Salvatore, Garaventa, Alberto, DʼAngelo, Paolo, Lo Nigro, Luca, Santoro, Nicola, Piglione, Matilde, Lombardi, Alessandra, Porta, Fulvio, Cesaro, Simone, Moleti, Maria L., Casale, Fiorina, Mura, Rossella, dʼAmore, Emanuele S. G., Basso, Giuseppe, and Rosolen, Angelo

Published
2015
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13. Prognostic Role of Minimal Disseminated Disease and NOTCH1/FBXW7 Mutational Status in Children with Lymphoblastic Lymphoma: The AIEOP Experience

Author

Lovisa, Federica, primary, Gallingani, Ilaria, additional, Varotto, Elena, additional, Pasin, Cristiano, additional, Carraro, Elisa, additional, Michielotto, Barbara, additional, Garbin, Anna, additional, Damanti, Carlotta Caterina, additional, Pizzi, Marco, additional, d’Amore, Emanuele S. G., additional, Piglione, Matilde, additional, Muggeo, Paola, additional, Buffardi, Salvatore, additional, Vinti, Luciana, additional, Folsi, Veronica Maria, additional, Onofrillo, Daniela, additional, Biffi, Alessandra, additional, Buldini, Barbara, additional, Pillon, Marta, additional, and Mussolin, Lara, additional

Published
2021
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15. Pembrolizumab (pembro) in Children and Young Adults with High-Risk Classical Hodgkin Lymphoma (cHL) with Slow Early Response (SER) to Front-Line Chemotherapy (chemo): Updated Results from the Phase 2 Keynote-667 Study

Author

Mauz-Koerholz, Christine, Beishuizen, Auke, Vinti, Luciana, Ceraulo, Antony, Michel, Gerard, Cepelova, Michaela, Fagioli, Franca, Sabado Alvarez, Constantino, Ducassou, Stephane, Buffardi, Salvatore, Andión Catalan, Maitane, Hoppe, Brad, Keller, Frank, Kelly, Kara M., Roth, Lisa Giulino, Landman-Parker, Judith, Shen, Juan, Pillai, Pallavi, and Daw, Stephen

Published
2023
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17. Prospective Evaluation of Different Methods for Volumetric Analysis on [ 18 F]FDG PET/CT in Pediatric Hodgkin Lymphoma.

Author

Lopci, Egesta, Elia, Caterina, Catalfamo, Barbara, Burnelli, Roberta, De Re, Valli, Mussolin, Lara, Piccardo, Arnoldo, Cistaro, Angelina, Borsatti, Eugenio, Zucchetta, Pietro, Bianchi, Maurizio, Buffardi, Salvatore, Farruggia, Piero, Garaventa, Alberto, Sala, Alessandra, Vinti, Luciana, Mauz-Koerholz, Christine, and Mascarin, Maurizio

Subjects
VOLUMETRIC analysis, CHILDHOOD cancer, HODGKIN'S disease, EVALUATION methodology, ABSOLUTE value
Abstract

Rationale: Therapy response evaluation by 18F-fluorodeoxyglucose PET/CT (FDG PET) has become a powerful tool for the discrimination of responders from non-responders in pediatric Hodgkin lymphoma (HL). Recently, volumetric analyses have been regarded as a valuable tool for disease prognostication and biological characterization in cancer. Given the multitude of methods available for volumetric analysis in HL, the AIEOP Hodgkin Lymphoma Study Group has designed a prospective analysis of the Italian cohort enrolled in the EuroNet-PHL-C2 trial. Methods: Primarily, the study aimed to compare the different segmentation techniques used for volumetric assessment in HL patients at baseline (PET1) and during therapy: early (PET2) and late assessment (PET3). Overall, 50 patients and 150 scans were investigated for the current analysis. A dedicated software was used to semi-automatically delineate contours of the lesions by using different threshold methods. More specifically, four methods were applied: (1) fixed 41% threshold of the maximum standardized uptake value (SUVmax) within the respective lymphoma site (V41%), (2) fixed absolute SUV threshold of 2.5 (V2.5); (3) SUVmax(lesion)/SUVmean liver >1.5 (Vliver); (4) adaptive method (AM). All parameters obtained from the different methods were analyzed with respect to response. Results: Among the different methods investigated, the strongest correlation was observed between AM and Vliver (rho > 0.9; p < 0.001 for SUVmean, MTV and TLG at all scan timing), along with V2.5 and AM or Vliver (rho 0.98, p < 0.001 for TLG at baseline; rho > 0.9; p < 0.001 for SUVmean, MTV and TLG at PET2 and PET3, respectively). To determine the best segmentation method, we applied logistic regression and correlated different results with Deauville scores at late evaluation. Logistic regression demonstrated that MTV (metabolic tumor volume) and TLG (total lesion glycolysis) computation according to V2.5 and Vliver significantly correlated to response to treatment (p = 0.01 and 0.04 for MTV and 0.03 and 0.04 for TLG, respectively). SUVmean also resulted in significant correlation as absolute value or variation. Conclusions: The best correlation for volumetric analysis was documented for AM and Vliver, followed by V2.5. The volumetric analyses obtained from V2.5 and Vliver significantly correlated to response to therapy, proving to be preferred thresholds in our pediatric HL cohort. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

Author

Repetto, Ombretta, primary, Lovisa, Federica, additional, Elia, Caterina, additional, Enderle, Daniel, additional, Romanato, Filippo, additional, Buffardi, Salvatore, additional, Sala, Alessandra, additional, Pillon, Marta, additional, Steffan, Agostino, additional, Burnelli, Roberta, additional, Mussolin, Lara, additional, Mascarin, Maurizio, additional, and De Re, Valli, additional

Published
2021
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20. HL-032: Nivolumab and Brentuximab Vedotin (BV)–Based, Response-Adapted Treatment in Children, Adolescents, and Young Adults (CAYA) With Standard-Risk Relapsed/Refractory Classical Hodgkin Lymphoma (R/R cHL): Primary Analysis of the Standard-Risk Cohort of the Phase 2 CheckMate 744 Study

Author

Cole, Peter D., primary, Mauz-Körholz, Christine, additional, Mascarin, Maurizio, additional, Michel, Gérard, additional, Cooper, Stacy, additional, Beishuizen, Auke, additional, Leger, Kasey J., additional, Amoroso, Loredana, additional, Buffardi, Salvatore, additional, Rigaud, Charlotte, additional, Puhlmann, Markus, additional, Francis, Stephen, additional, Sacchi, Mariana, additional, Drachtman, Richard A., additional, Harker-Murray, Paul, additional, Leblanc, Thierry, additional, Daw, Stephen, additional, and Kelly, Kara M., additional

Published
2020
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21. Comparison of Hodgkin’s Lymphoma in Children and Adolescents. A Twenty Year Experience with MH’96 and LH2004 AIEOP (Italian Association of Pediatric Hematology and Oncology) Protocols

Author

Burnelli, Roberta, primary, Fiumana, Giulia, additional, Rondelli, Roberto, additional, Pillon, Marta, additional, Sala, Alessandra, additional, Garaventa, Alberto, additional, D’Amore, Emanuele S.G., additional, Sabattini, Elena, additional, Buffardi, Salvatore, additional, Bianchi, Maurizio, additional, Vinti, Luciana, additional, Zecca, Marco, additional, Muggeo, Paola, additional, Provenzi, Massimo, additional, Farruggia, Piero, additional, Rossi, Francesca, additional, D’Amico, Salvatore, additional, Facchini, Elena, additional, Bernasconi, Sayla, additional, De Santis, Raffaela, additional, Casini, Tommaso, additional, Porta, Fulvio, additional, D’Alba, Irene, additional, Mura, Rosamaria, additional, Verzegnassi, Federico, additional, Sau, Antonella, additional, Cesaro, Simone, additional, Perruccio, Katia, additional, Cellini, Monica, additional, Bertolini, Patrizia, additional, Sperlì, Domenico, additional, Pericoli, Roberta, additional, Galimberti, Daniela, additional, Civino, Adele, additional, and Mascarin, Maurizio, additional

Published
2020
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22. Nivolumab and brentuximab vedotin (BV)-based, response‐adapted treatment in children, adolescents, and young adults (CAYA) with standard-risk relapsed/refractory classical Hodgkin lymphoma (R/R cHL): Primary analysis.

Author

Cole, Peter D., primary, Mauz-Körholz, Christine, additional, Mascarin, Maurizio, additional, Michel, Gérard, additional, Cooper, Stacy, additional, Beishuizen, Auke, additional, Leger, Kasey J., additional, Amoroso, Loredana, additional, Buffardi, Salvatore, additional, Rigaud, Charlotte, additional, Puhlmann, Markus, additional, Francis, Stephen, additional, Sacchi, Mariana, additional, Drachtman, Richard A., additional, Harker-Murray, Paul David, additional, Leblanc, Thierry, additional, Daw, Stephen, additional, and Kelly, Kara M., additional

Published
2020
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24. Minimal residual disease analysis in childhood mature B‐cell leukaemia/lymphoma treated with AIEOP LNH‐97 protocol with/without anti‐CD20 administration

Author

Mussolin, Lara, primary, Lovisa, Federica, additional, Gallingani, Ilaria, additional, Cavallaro, Elena, additional, Carraro, Elisa, additional, Damanti, Carlotta C., additional, Vinti, Luciana, additional, Sala, Alessandra, additional, Micalizzi, Concetta, additional, Santoro, Nicola, additional, Piglione, Matilde, additional, Cellini, Monica, additional, Buffardi, Salvatore, additional, Buldini, Barbara, additional, D’Amore, Emanuele S. G., additional, Biffi, Alessandra, additional, and Pillon, Marta, additional

Published
2020
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25. Response-Adapted Treatment with Nivolumab and Brentuximab Vedotin (BV) in Children, Adolescents and Young Adults (CAYA) with Relapsed/Refractory Classical Hodgkin Lymphoma (R/R cHL): CheckMate 744 Subgroup Analyses

Author

Kelly, Kara M., primary, Daw, Stephen, additional, Mauz-Körholz, Christine, additional, Mascarin, Maurizio, additional, Michel, Gerard, additional, Cooper, Stacy, additional, Beishuizen, Auke, additional, Leger, Kasey J., additional, Garaventa, Alberto, additional, Buffardi, Salvatore, additional, Brugières, Laurence, additional, Harker-Murray, Paul, additional, Cole, Peter D., additional, Drachtman, Richard A., additional, Manley, Thomas, additional, Francis, Stephen, additional, Sacchi, Mariana, additional, and Leblanc, Thierry, additional

Published
2019
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26. Single center experience on efficacy and safety of Aprepitant for preventing chemotherapy-induced nausea and vomiting (CINV) in pediatric Hodgkin Lymphoma

Author

Giagnuolo, Giovanna, primary, Buffardi, Salvatore, additional, Rossi, Francesca, additional, Petruzziello, Fara, additional, Tortora, Chiara, additional, Buffardi, Isabella, additional, Marra, Nicoletta, additional, Beneduce, Giuliana, additional, Menna, Giuseppe, additional, and Parasole, Rosanna, additional

Published
2019
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27. A high definition picture of key genes and pathways mutated in pediatric follicular lymphoma

Author

Lovisa, Federica, primary, Binatti, Andrea, additional, Coppe, Alessandro, additional, Primerano, Simona, additional, Carraro, Elisa, additional, Pillon, Marta, additional, Pizzi, Marco, additional, Guzzardo, Vincenza, additional, Buffardi, Salvatore, additional, Porta, Fulvio, additional, Farruggia, Piero, additional, De Santis, Raffaela, additional, Bulian, Pietro, additional, Basso, Giuseppe, additional, Lazzari, Elena, additional, d’Amore, Emanuele S.G., additional, Bortoluzzi, Stefania, additional, and Mussolin, Lara, additional

Published
2019
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28. Response-Adapted Therapy with Nivolumab and Brentuximab Vedotin (BV), Followed By BV and Bendamustine for Suboptimal Response, in Children, Adolescents, and Young Adults with Standard-Risk Relapsed/Refractory Classical Hodgkin Lymphoma

Author

Harker-Murray, Paul, primary, Leblanc, Thierry, additional, Mascarin, Maurizio, additional, Mauz-Körholz, Christine, additional, Michel, Gerard, additional, Cooper, Stacy, additional, Beishuizen, Auke, additional, Leger, Kasey J., additional, Garaventa, Alberto, additional, Buffardi, Salvatore, additional, Brugieres, Laurence, additional, Kelly, Kara M., additional, Cole, Peter D., additional, Drachtman, Richard A., additional, Galderisi, Faith, additional, Sacchi, Mariana, additional, Jou, Ying-Ming, additional, and Daw, Stephen, additional

Published
2018
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29. Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience

Author

Farruggia, Piero, primary, Puccio, Giuseppe, additional, Locatelli, Francesco, additional, Vetro, Mariarita, additional, Pillon, Marta, additional, Trizzino, Angela, additional, Sala, Alessandra, additional, Buffardi, Salvatore, additional, Garaventa, Alberto, additional, Rossi, Francesca, additional, Bianchi, Maurizio, additional, Zecca, Marco, additional, Pession, Andrea, additional, Favre, Claudio, additional, D’Amico, Salvatore, additional, Provenzi, Massimo, additional, Zanazzo, Giulio Andrea, additional, Sau, Antonella, additional, Santoro, Nicola, additional, Mura, Rosamaria, additional, Elia, Caterina, additional, Casini, Tommaso, additional, Mascarin, Maurizio, additional, and Burnelli, Roberta, additional

Published
2018
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33. HLA-G+3027 polymorphism is associated with tumor relapse in pediatric Hodgkin's lymphoma

Author

De Re, Valli, primary, Caggiari, Laura, additional, Mussolin, Lara, additional, d’Amore, Emanuele Stefano, additional, Famengo, Barbara, additional, De Zorzi, Mariangela, additional, Martina, Lia, additional, Elia, Caterina, additional, Pillon, Marta, additional, Santoro, Nicola, additional, Muggeo, Paola, additional, Buffardi, Salvatore, additional, Bianchi, Maurizio, additional, Sala, Alessandra, additional, Farruggia, Piero, additional, Vinti, Luciana, additional, Carosella, Edgardo D., additional, Burnelli, Roberta, additional, and Mascarin, Maurizio, additional

Published
2017
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34. Classical pediatric Hodgkin lymphoma in very young patients: the Italian experience.

Author

Farruggia, Piero, Puccio, Giuseppe, Locatelli, Francesco, Vetro, Mariarita, Pillon, Marta, Trizzino, Angela, Sala, Alessandra, Buffardi, Salvatore, Garaventa, Alberto, Rossi, Francesca, Bianchi, Maurizio, Zecca, Marco, Pession, Andrea, Favre, Claudio, D'Amico, Salvatore, Provenzi, Massimo, Zanazzo, Giulio Andrea, Sau, Antonella, Santoro, Nicola, and Mura, Rosamaria

Subjects
HODGKIN'S disease, NATURAL history, FACTOR analysis, MULTIVARIATE analysis
Abstract

Many studies have reported a more favorable outcome in younger patients with Hodgkin lymphoma (HL). The aims of this study were to find an appropriate age cutoff able to identify low-risk children and to describe the natural history of 135 very young patients affected by classic HL (cHL). The best age cutoff was identified at 7 years of age. EFS (p =.0451) and PFS (p =.00921) were significantly better in the group of younger patients. The OS rate at 10 years was 97.0% in the younger group and 92.5% in the older one (p =.0448). However, age was not found to be an independent prognostic factor in multivariate analysis and the better prognosis in younger patients seems to be related to more favorable disease characteristics at presentation. [ABSTRACT FROM AUTHOR]

Published
2019
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35. Detection of prognostic factors in children and adolescents with Burkitt and Diffuse Large B-Cell Lymphoma treated with the AIEOP LNH-97 protocol

Author

Pillon, Marta, primary, Mussolin, Lara, additional, Carraro, Elisa, additional, Conter, Valentino, additional, Aricò, Maurizio, additional, Vinti, Luciana, additional, Garaventa, Alberto, additional, Piglione, Matilde, additional, Buffardi, Salvatore, additional, Sala, Alessandra, additional, Santoro, Nicola, additional, Lo Nigro, Luca, additional, Mura, Rossella, additional, Tondo, Annalisa, additional, Casale, Fiorina, additional, Farruggia, Piero, additional, Pierani, Paolo, additional, Cesaro, Simone, additional, d'Amore, Emanuele S. G., additional, and Basso, Giuseppe, additional

Published
2016
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36. FDG PET in response evaluation of bulky masses in paediatric Hodgkin’s lymphoma (HL) patients enrolled in the Italian AIEOP-LH2004 trial.

Author

AIEOP Hodgkin Lymphoma Study Group, Italy, Lopci, Egesta, Castello, Angelo, Cistaro, Angelina, Buffardi, Salvatore, Bertolini, Patrizia, Bianchi, Maurizio, Fagioli, Franca, Moleti, Maria Luisa, Bunkheila, Feisal, Indolfi, Paolo, Garaventa, Alberto, Burnelli, Roberta, Mascarin, Maurizio, Elia, Caterina, Piccardo, Arnoldo, Guerra, Luca, Borsatti, Eugenio, Sala, Alessandra, and Todesco, Alessandra

Subjects
HODGKIN'S disease in children, FLUORODEOXYGLUCOSE F18, POSITRON emission, PEDIATRICS, DATA analysis, CLINICAL trials
Abstract

Purpose: We present the results of an investigation of the role of FDG PET in response evaluation of bulky masses in paediatric patients with Hodgkin’s lymphoma (HL) enrolled in the Italian AIEOP-LH2004 trial.Methods: We analysed data derived from 703 patients (388 male, 315 female; mean age 13 years) with HL and enrolled in 41 different Italian centres from March 2004 to September 2012, all treated with the AIEOP-LH2004 protocol. The cohort comprised 309 patients with a bulky mass, of whom 263 were evaluated with FDG PET at baseline and after four cycles of chemotherapy. Responses were determined according to combined functional and morphological criteria. Patients were followed up for a mean period of 43 months and for each child we calculated time-to-progression (TTP) and relapse rates considering clinical monitoring, and instrumental and histological data as the reference standard. Statistical analyses were performed for FDG PET and morphological responses with respect to TTP. Multivariate analysis was used to define independent predictive factors.Results: Overall, response evaluation revealed 238 PET-negative patients (90.5%) and 25 PET-positive patients (9.5%), with a significant difference in TTP between these groups (mean TTP: 32.67 months for negative scans, 23.8 months for positive scans; p < 0.0001, log-rank test). In the same cohort, computed tomography showed a complete response (CR) in 85 patients (32.3%), progressive disease (PD) in 6 patients (2.3%), and a partial response (PR) in 165 patients (62.7%), with a significant difference in TTP between patients with CR and patients with PD (31.1 months and 7.9 months, respectively; p < 0.001, log-rank test). Similarly, there was a significant difference in relapse rates between PET-positive and PET-negative patients (p = 0000). In patients with PR, there was also a significant difference in TTP between PET-positive and PET-negative patients (24.6 months and 34.9 months, respectively; p < 0.0001). In the multivariate analysis with correction for multiple testing, only the PET result was an independent predictive factor in both the entire cohort of patients and the subgroup showing PR on CT (p < 0.01).Conclusion: After four cycles of chemotherapy, FDG PET response assessment in paediatric HL patients with a bulky mass is a good predictor of TTP and disease outcome. Moreover, in patients with a PR on CT, PET was able to differentiate those with a longer TTP. In paediatric HL patients with a bulky mass and in patients with a PR on CT, response on FDG PET was an independent predictive factor. [ABSTRACT FROM AUTHOR]

Published
2019
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37. The prognostic value of biological markers in paediatric Hodgkin lymphoma

Author

Farruggia, Piero, primary, Puccio, Giuseppe, additional, Sala, Alessandra, additional, Todesco, Alessandra, additional, Buffardi, Salvatore, additional, Garaventa, Alberto, additional, Bottigliero, Gaetano, additional, Bianchi, Maurizio, additional, Zecca, Marco, additional, Locatelli, Franco, additional, Pession, Andrea, additional, Pillon, Marta, additional, Favre, Claudio, additional, D'Amico, Salvatore, additional, Provenzi, Massimo, additional, Trizzino, Angela, additional, Zanazzo, Giulio Andrea, additional, Sau, Antonella, additional, Santoro, Nicola, additional, Murgia, Giulio, additional, Casini, Tommaso, additional, Mascarin, Maurizio, additional, Burnelli, Roberta, additional, Cesaro, Simone, additional, Zaccaron, Ada, additional, Bertolini, Patrizia, additional, Consarino, Caterina, additional, Iaria, Grazia, additional, Pericoli, Roberta, additional, Pierani, Paolo, additional, Fedeli, Fausto, additional, Cellini, Monica, additional, De Santis, Raffaela, additional, Porta, Fulvio, additional, Caini, Mauro, additional, Cosmi, Carlo, additional, Mirra, Nadia, additional, Civino, Adele, additional, Sperlì, Domenico, additional, Nespoli, Luigi, additional, Caniglia, Maurizio, additional, Perruccio, Katia, additional, D'Angelo, Paolo, additional, Passone, Eva, additional, Caruso, Roberta, additional, Scarzello, Giovanni, additional, and Rondelli, Roberto, additional

Published
2016
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41. Response-adapted therapy (tx) with nivolumab plus brentuximab vedotin (nivo + BV) without autologous hematopoietic cell transplantation (auto-HCT) in children, adolescents, and young adults (CAYA) with low-risk relapsed/refractory (R/R) classic...

Author

Harker-Murray, Paul David, Cole, Peter D., Hoppe, Bradford S., Hodgson, David C., Beishuizen, Auke, Garnier, Nathalie, Buffardi, Salvatore, Mascarin, Maurizio, Lissat, Andrej, Akyol, Alev, Crowe, Russell, Li, Ju, Drachtman, Richard A., Kelly, Kara M, Leblanc, Thierry, and Daw, Stephen

Published
2023
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42. Efficacy and safety of intrathecal liposomal cytarabine for the treatment of meningeal relapse in acute lymphoblastic leukemia: experience of two pediatric institutions

Author

Parasole, Rosanna, Menna, Giuseppe, Marra, Nicoletta, Petruzziello, Fara, Locatelli, Franco, Mangione, Argia, Misuraca, Aldo, Buffardi, Salvatore, Di Cesare-Merlone, Alessandra, Poggi, Vincenzo, Locatelli, Franco (ORCID:0000-0002-7976-3654), Parasole, Rosanna, Menna, Giuseppe, Marra, Nicoletta, Petruzziello, Fara, Locatelli, Franco, Mangione, Argia, Misuraca, Aldo, Buffardi, Salvatore, Di Cesare-Merlone, Alessandra, Poggi, Vincenzo, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

The treatment of meningeal relapse in acute lymphoblastic leukemia (ALL) remains a challenging clinical problem. Liposomal cytarabine (DepoCyte) permits to decrease frequency of lumbar punctures, without loss of efficacy, because intrathecal levels of the drug remain cytotoxic for up to 14 days. We investigated the efficacy and safety of intrathecal DepoCyte in six children with meningeal relapse, treated in two pediatric institutions. DepoCyte was well tolerated in all patients, who achieved complete clearance of blasts from the cerebrospinal fluid after the first three intrathecal drug administrations. Five of the six patients were concurrently treated with high-dose administration of systemic cytarabine, without additional neurological side effects. Our results suggest that DepoCyte is a valid option for children with ALL experiencing meningeal relapse; it deserves further investigation in intensive treatment regimens, taking into due consideration potential neurotoxicity.

Published
2008

43. Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate

Author

D’Angelo, Velia, primary, Ramaglia, Maria, additional, Iannotta, Adriana, additional, Francese, Matteo, additional, Pota, Elvira, additional, Affinita, Maria Carmen, additional, Pecoraro, Giulia, additional, Indolfi, Cristiana, additional, Di Martino, Martina, additional, Di Pinto, Daniela, additional, Buffardi, Salvatore, additional, Poggi, Vincenzo, additional, Indolfi, Paolo, additional, and Casale, Fiorina, additional

Published
2013
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46. Minimal Disseminated Disease Is An Independent Poor Prognosis Marker Among High Risk Burkitt's Lymphoma Patients .

Author

Mussolin, Lara, primary, Pillon, Marta, additional, Tridello, Gloria, additional, Boaro, Maria Paola, additional, d'Amore, Emanuele S, additional, Nigro, Luca Lo, additional, Buffardi, Salvatore, additional, Lombardi, Alessandra, additional, Sala, Alessandra, additional, Favre, Claudio, additional, Aricò, Maurizio, additional, and Rosolen, Angelo, additional

Published
2009
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47. Efficacy and safety of intrathecal liposomal cytarabine for the treatment of meningeal relapse in acute lymphoblastic leukemia: Experience of two pediatric institutions

Author

Parasole, Rosanna, primary, Menna, Giuseppe, additional, Marra, Nicoletta, additional, Petruzziello, Fara, additional, Locatelli, Franco, additional, Mangione, Argia, additional, Misuraca, Aldo, additional, Buffardi, Salvatore, additional, Di Cesare-Merlone, Alessandra, additional, and Poggi, Vincenzo, additional

Published
2008
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49. Fungal Infections in Children With Cancer

Author

Castagnola, Elio, primary, Cesaro, Simone, additional, Giacchino, Mareva, additional, Livadiotti, Susanna, additional, Tucci, Fabio, additional, Zanazzo, Giulio, additional, Caselli, Desirè, additional, Caviglia, Ilaria, additional, Parodi, Stefano, additional, Rondelli, Roberto, additional, Cornelli, Pier Emilo, additional, Mura, Rossella, additional, Santoro, Nicola, additional, Russo, Giovanna, additional, De Santis, Raffaella, additional, Buffardi, Salvatore, additional, Viscoli, Claudio, additional, Haupt, Riccardo, additional, and Rossi, Mario R., additional

Published
2006
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