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Your search keyword '"Buitrago-Pocasangre, Nicholas C."' showing total 3 results
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3 results on '"Buitrago-Pocasangre, Nicholas C."'

1. Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma

Author

Lu, Benjamin Y., Lucca, Liliana E., Lewis, Wesley, Wang, Jiping, Nogueira, Catarina V., Heer, Sebastian, Rayon-Estrada, Violeta, Axisa, Pierre-Paul, Reeves, Sarah M., Buitrago-Pocasangre, Nicholas C., Pham, Giang H., Kojima, Mina L., Wei, Wei, Aizenbud, Lilach, Bacchiocchi, Antonietta, Zhang, Lin, Walewski, Joseph J., Chiang, Veronica, Olino, Kelly, Clune, James, Halaban, Ruth, Kluger, Yuval, Coyle, Anthony J., Kisielow, Jan, Obermair, Franz-Josef, Kluger, Harriet M., and Hafler, David A.

Published
2025
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2. Circulating tumor-reactive KIR+CD8+T cells suppress anti-tumor immunity in patients with melanoma

Author

Lu, Benjamin Y., Lucca, Liliana E., Lewis, Wesley, Wang, Jiping, Nogueira, Catarina V., Heer, Sebastian, Rayon-Estrada, Violeta, Axisa, Pierre-Paul, Reeves, Sarah M., Buitrago-Pocasangre, Nicholas C., Pham, Giang H., Kojima, Mina L., Wei, Wei, Aizenbud, Lilach, Bacchiocchi, Antonietta, Zhang, Lin, Walewski, Joseph J., Chiang, Veronica, Olino, Kelly, Clune, James, Halaban, Ruth, Kluger, Yuval, Coyle, Anthony J., Kisielow, Jan, Obermair, Franz-Josef, Kluger, Harriet M., and Hafler, David A.

Abstract

Effective anti-tumor immunity is driven by cytotoxic CD8+T cells with specificity for tumor antigens. However, the factors that control successful tumor rejection are not well understood. Here we identify a subpopulation of CD8+T cells that are tumor-antigen-specific and can be identified by KIR expression but paradoxically impair anti-tumor immunity in patients with melanoma. These tumor-antigen-specific KIR+CD8+regulatory T cells target other tumor-antigen-specific CD8+T cells, can be detected in both the tumor and the blood, have a conserved transcriptional program and are associated with a poor overall survival. These findings broaden our understanding of the transcriptional and functional heterogeneity of human CD8+T cells and implicate KIR+CD8+regulatory T cells as a cellular mediator of immune evasion in human cancer.

Published
2025
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3. Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination

Author

Asashima, Hiromitsu, primary, Kim, Dongjoo, additional, Wang, Kaicheng, additional, Lele, Nikhil, additional, Buitrago-Pocasangre, Nicholas C., additional, Lutz, Rachel, additional, Cruz, Isabella, additional, Raddassi, Khadir, additional, Ruff, William E., additional, Racke, Michael K., additional, Wilson, JoDell E., additional, Givens, Tara S., additional, Grifoni, Alba, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Kleinstein, Steven H., additional, Montgomery, Ruth R., additional, Shaw, Albert C., additional, Li, Fangyong, additional, Fan, Rong, additional, Hafler, David A., additional, Tomayko, Mary M., additional, and Longbrake, Erin E., additional

Published
2023
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