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2. Disposable versus Reusable Ureteroscopes: A Prospective Multicenter Randomized Comparison

Author

Bozzini G, Filippi B, Alriyalat S, Calori A, Besana U, Mueller A, Pushkar D, Romero-Otero J, Pastore A, Sighinolfi MC, Micali S, Buizza C, and Rocco B

Subjects
rirs, disposable ureteroscope, reusable ureteroscope, infection., Diseases of the genitourinary system. Urology, RC870-923
Abstract

Giorgio Bozzini,1 Beatrice Filippi,2 Sulieman Alriyalat,3 Alberto Calori,1 Umberto Besana,1 Alexander Mueller,4 Dmitri Pushkar,5 Javier Romero-Otero,6 Antonio Pastore,7 Maria Chiara Sighinolfi,2 Salvatore Micali,2 Carlo Buizza,1 Bernardo Rocco2 1Urology Department, ASST Valle Olona, Busto Arsizio, Varese, Italy; 2Urology Department, Policlinico of Modena, Modena, Italy; 3Urology Department, Al-Balqa Applied University, Al-Salt, Jordan; 4Department of Urology, University Hospital Zurich, Zurich, Switzerland; 5Urology Department First Moscow State Medical University, Moscow, Russia; 6Department of Urology, Hospital Universitario 12 de Octubre, Madrid, Spain; 7Urology Department, Università “La Sapienza”, Latina, ItalyCorrespondence: Beatrice FilippiUrology Department, Policlinico di Modena, Via del Pozzo, n. 71, Modena, 41125, ItalyTel +39 3403904011Email beatrice.filippi87@gmail.comPurpose: To compare reusable and disposable flexible ureteroscopes in terms of efficacy and safety for patients undergoing Retrograde Intrarenal Surgery (RIRS).Patients and Methods: Patients with a renal stone eligible for RIRS were enrolled in this multicenter, randomized, clinical trial study. Patients were randomized into two groups: group A (90 patients) underwent RIRS with a reusable flexible ureteroscope and group B (90 patients) were treated with a disposable one.Results: The patients’ demographics, stone features and pre-operative urine cultures were comparable between the groups. The Stone Free Rates (SFRs) were not significantly different (86.6% and 90.0% for group A and group B, respectively, p=0.11) and the mean cost for each procedure was comparable (2321 € in group A vs 2543 € in group B, p=0.09). However, the days of hospitalization and of antibiotic therapy were higher in group A (p ≤ 0.05). The overall complication rate in group A was 8.8% whilst in group B it was 3.3% (p ≤ 0.05); in particular, group A exhibited a greater number of major complications (Clavien score IIIa-V). The overall postoperative infection rate was 16.6% in group A and 3.3% in group B (p ≤ 0.05). Furthermore, none of the patients in group B developed urosepsis or had a positive blood culture, while 3 patients in group A did (p< 0.05).Conclusion: The use of disposable ureteroscopes is characterized by significantly lower post-operative complications and infection rates, while having comparable costs and SFRs vis à vis reusable ureteroscopes. Clinical Trial Registration Number: ISRCTN92289221.Keywords: RIRS, disposable ureteroscope, reusable ureteroscope, infection

Published
2021

3. Who is likely to vacillate in their COVID-19 vaccination decision? Free-riding intention and post-positive reluctance

Author

Caserotti, M, Gavaruzzi, T, Girardi, P, Tasso, A, Buizza, C, Candini, V, Zarbo, C, Chiarotti, F, Brescianini, S, Calamandrei, G, Starace, F, de Girolamo, G, Lotto, L, Caserotti M, Gavaruzzi T, Girardi P, Tasso A, Buizza C, Candini V, Zarbo C, Chiarotti F, Brescianini S, Calamandrei G, Starace F, de Girolamo G, Lotto L, Caserotti, M, Gavaruzzi, T, Girardi, P, Tasso, A, Buizza, C, Candini, V, Zarbo, C, Chiarotti, F, Brescianini, S, Calamandrei, G, Starace, F, de Girolamo, G, Lotto, L, Caserotti M, Gavaruzzi T, Girardi P, Tasso A, Buizza C, Candini V, Zarbo C, Chiarotti F, Brescianini S, Calamandrei G, Starace F, de Girolamo G, and Lotto L

Abstract

Despite the actual availability of COVID-19 vaccines to combat the pandemic, many people are still vacillating in their decision to vaccinate. In this study, we considered the effect of two relevant contextual issues on vaccination intention: the number of people infected with COVID-19 is increasing, and the pace of vaccination is gaining speed. Specifically, we hypothesized that having already contracted SARS-CoV-2 (post-positive reluctance) could lead people to underestimate the importance of vaccination. Moreover, as the number of vaccinated people increases, more hesitant people could fall into the free-riding intention category, benefitting from the immunity provided by others' vaccinations. Vaccine hesitancy becomes more critical as the vaccination campaign proceeds: at one point, it will be inevitable to deal with hesitant people. This study is part of a WHO Regional Office for Europe project and involved a representative sample of 5006 Italians interviewed in January–February 2021. In case of post-positive reluctance, both young age and female gender increase vaccine hesitancy, while a high level of education reduces free-riding intention. Considering post-positive reluctance and free riding, a protective effect on hesitancy is associated with negative affective states, adherence to protective behaviors, trust in health information sources, and resilience. In contrast, increased vaccine hesitancy is associated with a high level of conspiracy-mindedness and trust in media information sources. Recognizing and studying the post-positive reluctance and the phenomenon of free-riding people can help us to become more efficient in combatting the virus.

Published
2022

4. Psychological well-being during the COVID-19 pandemic in Italy assessed in a four-waves survey

Author

de Girolamo, G, Ferrari, C, Candini, V, Buizza, C, Calamandrei, G, Caserotti, M, Gavaruzzi, T, Girardi, P, Habersaat, K, Lotto, L, Scherzer, M, Starace, F, Tasso, A, Zamparini, M, Zarbo, C, de Girolamo G, Ferrari C, Candini V, Buizza C, Calamandrei G, Caserotti M, Gavaruzzi T, Girardi P, Habersaat KB, Lotto L, Scherzer M, Starace F, Tasso A, Zamparini M, Zarbo C, de Girolamo, G, Ferrari, C, Candini, V, Buizza, C, Calamandrei, G, Caserotti, M, Gavaruzzi, T, Girardi, P, Habersaat, K, Lotto, L, Scherzer, M, Starace, F, Tasso, A, Zamparini, M, Zarbo, C, de Girolamo G, Ferrari C, Candini V, Buizza C, Calamandrei G, Caserotti M, Gavaruzzi T, Girardi P, Habersaat KB, Lotto L, Scherzer M, Starace F, Tasso A, Zamparini M, and Zarbo C

Abstract

COVID-19 pandemic had a negative impact on the mental health and well-being (WB) of citizens. This cross-sectional study included 4 waves of data collection aimed at identifying profiles of individuals with different levels of WB. The study included a representative stratified sample of 10,013 respondents in Italy. The WHO 5-item well-being scale (WHO-5) was used for the assessment of WB. Different supervised machine learning approaches (multinomial logistic regression, partial least-square discriminant analysis—PLS-DA—, classification tree—CT—) were applied to identify individual characteristics with different WB scores, first in waves 1–2 and, subsequently, in waves 3 and 4. Forty-one percent of participants reported “Good WB”, 30% “Poor WB”, and 28% “Depression”. Findings carried out using multinomial logistic regression show that Resilience was the most important variable able for discriminating the WB across all waves. Through the PLS-DA, Increased Unhealthy Behaviours proved to be the more important feature in the first two waves, while Financial Situation gained most relevance in the last two. COVID-19 Perceived Risk was relevant, but less than the other variables, across all waves. Interestingly, using the CT we were able to establish a cut-off for Resilience (equal to 4.5) that discriminated good WB with a probability of 65% in wave 4. Concluding, we found that COVID-19 had negative implications for WB. Governments should support evidence-based strategies considering factors that influence WB (i.e., Resilience, Perceived Risk, Healthy Behaviours, and Financial Situation).

Published
2022

5. Treatment of ureteral stones with lithoevo device and vapor tunnel tool

Author

Perri, D., primary, Maltagliati, M., additional, Berti, L., additional, Buizza, C., additional, Besana, U., additional, Pacchetti, A., additional, Morini, E., additional, Micali, S., additional, Rocco, B., additional, Sighinolfi, M.C., additional, Sciorio, C., additional, Pastore, A.L., additional, Pushkar, D., additional, Govorov, A., additional, Romero-Otero, J., additional, and Bozzini, G., additional

Published
2022
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11. Treatment of ureteral stone with LithoEvo device and Vapor Tunnel tool

Author

Maltagliati, M., primary, Berti, L., additional, Besana, U., additional, Buizza, C., additional, Perri, D., additional, Micali, S., additional, Rocco, B., additional, Sighinolfi, M.C., additional, Sciorio, C., additional, Pastore, A.L., additional, Pushkar, D., additional, Govorov, A., additional, Romero Otero, J., additional, and Bozzini, G., additional

Published
2022
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17. Lesiones relacionadas con la vaina de acceso ureteral frente a infecciones postoperatorias. ¿Es siempre necesaria la inserción de la vaina de acceso? Estudio prospectivo aleatorizado para comprender las luces y sombras de esta práctica

Author

Bozzini, G., primary, Bevilacqua, L., additional, Besana, U., additional, Calori, A., additional, Pastore, A., additional, Romero Otero, J., additional, Macchi, A., additional, Broggini, P., additional, Breda, A., additional, Gozen, A., additional, Inzillo, R., additional, Puliatti, S., additional, Sighinolfi, M.C., additional, Rocco, B., additional, Liatsikos, E., additional, Muller, A., additional, and Buizza, C., additional

Published
2021
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28. Post-enucleation morcellation procedure: Lights and shadows

Author

Maltagliati, M., primary, Berti, L., additional, Buizza, C., additional, Rivolta, L., additional, Gastaldi, C., additional, Pedaci, G., additional, Malvestiti, G., additional, Autieri, G., additional, Sighinolfi, M.C., additional, Micali, S., additional, Rocco, B., additional, and Bozzini, G., additional

Published
2021
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29. Thulium-laser retrograde intra renal ablation of upper urinary tract transitional cell carcinoma: An ESUT Study

Author

Bozzini, G. Gastaldi, C. Besana, U. Calori, A. Casellato, S. Parma, P. Store, A.P. MacChi, A. Breda, A. Gozen, A. Skolarikos, A. Herrmann, T. Scoffone, C. Eissa, A. Sighinolfi, M.C. Rocco, B. Buizza, C. Liatsikos, E.

Abstract

BACKGROUND: Radical nephroureterectomy (RNU) is the gold standard treatment for upper urinary tract urothelial carcinoma (UTUC); however, patients presenting with small low-grade UTUC have been treated by flexible ureteroscopic laser ablation with good outcomes. Different types of laser have been discussed in the literature including Holmium and Neodymium lasers. We aimed to assess the safety and efficacy of Thulium laser (Tm:YAG) in the ureteroscopic ablation of UTUC. METHODS: A retrospective observational multicentre study of patients diagnosed with papillary UTUC between January 2015 and December 2016 was carried out. All patients underwent ureteroscopic biopsy of the UTUC followed by Tm:YAG ablation. Based on the histopathological grade of the tumor, patients were counseled to undergo either RNU (high-grade tumors) or conservative management and follow-up (low-grade tumor). RESULTS: RNU was performed in 31 patients, while the remaining 47 patients (undergone Tm:YAG ablation only) were followed up for a mean of 11.7 months with only 19.2% of patients showing upper tract recurrence and no patients showed postoperative ureteral strictures. Limitations include the short follow-up and retrospective nature of the study. CONCLUSIONS: On the short term, thulium Laser ablation of UTUC is safe and feasible especially in low-grade UTUC. © 2021 Minerva Urology and Nephrology. All rights reserved.

Published
2021

30. Margini e marginalità

Author

Bianchetti A., Rozzini R., Simeone D., Del Bono E., Tremolada A, Semeraro R., Gregorini G., Donato F., Magoni M., Triboldi A., Sileo C., Latronico N., Giannini A., Sergio Cattaneo, Frank Rasulo, Donati E., Tosi L., Di Stefano O., Pace S., Lucchi E., Palazzani L., Canobbio G., Pasini G., Rivoltella P. C., Amadini M., Buizza C., Mesa D., Angelini U., Bazoli F., Archetti M., Domenico S., Mesa, Diego, Buizza, Chiara, Diego Mesa (ORCID:0000-0003-0491-4988), Bianchetti A., Rozzini R., Simeone D., Del Bono E., Tremolada A, Semeraro R., Gregorini G., Donato F., Magoni M., Triboldi A., Sileo C., Latronico N., Giannini A., Sergio Cattaneo, Frank Rasulo, Donati E., Tosi L., Di Stefano O., Pace S., Lucchi E., Palazzani L., Canobbio G., Pasini G., Rivoltella P. C., Amadini M., Buizza C., Mesa D., Angelini U., Bazoli F., Archetti M., Domenico S., Mesa, Diego, Buizza, Chiara, and Diego Mesa (ORCID:0000-0003-0491-4988)

Abstract

Il contributo propone un'analisi dei cambiamenti delle forme di povertà e marginalità sociale indotti dall'emergenza Covid-19 nel contesto della città di Brescia

Published
2021

36. Stone related preoperative factors affecting postoperative PCNL Stone Free Rate (SFR)

Author

Gastaldi, C., primary, Bozzini, G., additional, Besana, U., additional, Broggini, P., additional, Bono, P., additional, Pedaci, G., additional, Puliatti, S., additional, Bevilacqua, L., additional, Ciarlariello, S., additional, Aydogan, T.B., additional, Sighinolfi, M.C., additional, Micali, S., additional, Rocco, B.M.C., additional, and Buizza, C., additional

Published
2020
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37. Ex vivo fluorescence confocal microscopy in the assessment of urothelial carcinoma grading in bladder and ureter: Our preliminary experience

Author

Puliatti, S., primary, Eissa, A., additional, Bevilacqua, L., additional, Morini, E., additional, Del Prete, C., additional, Ciarlariello, S., additional, Sighinolfi, M.C., additional, Spandri, V., additional, Azzoni, P., additional, Bertoni, L., additional, Reggiani Bonetti, L., additional, Bozzini, G., additional, Buizza, C., additional, Rocco, B., additional, Pellacani, G., additional, and Bianchi, G., additional

Published
2020
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48. Thulium laser en-bloc resection of bladder tumor (THUEB-BT): Tiger (thulium italian group established on research) study to compare laser and electrical en-bloc transurethral resection of bladder tumor

Author

Bozzini, G., primary, Maruccia, S., additional, Pastore, A., additional, Besana, U., additional, Parma, P., additional, Saredi, G., additional, Casellato, S., additional, Sighinolfi, M., additional, Puliatti, S., additional, Bevilacqua, L., additional, Rocco, B., additional, and Buizza, C., additional

Published
2019
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