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10 results on '"Bullock, Daniel N."'

1. brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Author

Hayashi, Soichi, Caron, Bradley A., Heinsfeld, Anibal Sólon, Vinci-Booher, Sophia, McPherson, Brent, Bullock, Daniel N., Bertò, Giulia, Niso, Guiomar, Hanekamp, Sandra, Levitas, Daniel, Ray, Kimberly, MacKenzie, Anne, Avesani, Paolo, Kitchell, Lindsey, Leong, Josiah K., Nascimento-Silva, Filipi, Koudoro, Serge, Willis, Hanna, Jolly, Jasleen K., Pisner, Derek, Zuidema, Taylor R., Kurzawski, Jan W., Mikellidou, Kyriaki, Bussalb, Aurore, Chaumon, Maximilien, George, Nathalie, Rorden, Christopher, Victory, Conner, Bhatia, Dheeraj, Aydogan, Dogu Baran, Yeh, Fang-Cheng F., Delogu, Franco, Guaje, Javier, Veraart, Jelle, Fischer, Jeremy, Faskowitz, Joshua, Fabrega, Ricardo, Hunt, David, McKee, Shawn, Brown, Shawn T., Heyman, Stephanie, Iacovella, Vittorio, Mejia, Amanda F., Marinazzo, Daniele, Craddock, R. Cameron, Olivetti, Emanuale, Hanson, Jamie L., Garyfallidis, Eleftherios, Stanzione, Dan, Carson, James, Henschel, Robert, Hancock, David Y., Stewart, Craig A., Schnyer, David, Eke, Damian O., Poldrack, Russell A., Bollmann, Steffen, Stewart, Ashley, Bridge, Holly, Sani, Ilaria, Freiwald, Winrich A., Puce, Aina, Port, Nicholas L., and Pestilli, Franco

Published
2024
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2. brainlife.io: A decentralized and open source cloud platform to support neuroscience research

Author

Hayashi, Soichi, Caron, Bradley A., Heinsfeld, Anibal Sólon, Vinci-Booher, Sophia, McPherson, Brent, Bullock, Daniel N., Bertò, Giulia, Niso, Guiomar, Hanekamp, Sandra, Levitas, Daniel, Ray, Kimberly, MacKenzie, Anne, Kitchell, Lindsey, Leong, Josiah K., Nascimento-Silva, Filipi, Koudoro, Serge, Willis, Hanna, Jolly, Jasleen K., Pisner, Derek, Zuidema, Taylor R., Kurzawski, Jan W., Mikellidou, Kyriaki, Bussalb, Aurore, Rorden, Christopher, Victory, Conner, Bhatia, Dheeraj, Aydogan, Dogu Baran, Yeh, Fang-Cheng F., Delogu, Franco, Guaje, Javier, Veraart, Jelle, Bollman, Steffen, Stewart, Ashley, Fischer, Jeremy, Faskowitz, Joshua, Chaumon, Maximilien, Fabrega, Ricardo, Hunt, David, McKee, Shawn, Brown, Shawn T., Heyman, Stephanie, Iacovella, Vittorio, Mejia, Amanda F., Marinazzo, Daniele, Craddock, R. Cameron, Olivetti, Emanuele, Hanson, Jamie L., Avesani, Paolo, Garyfallidis, Eleftherios, Stanzione, Dan, Carson, James, Henschel, Robert, Hancock, David Y., Stewart, Craig A., Schnyer, David, Eke, Damian O., Poldrack, Russell A., George, Nathalie, Bridge, Holly, Sani, Ilaria, Freiwald, Winrich A., Puce, Aina, Port, Nicholas L., and Pestilli, Franco

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Quantitative Biology - Neurons and Cognition, Quantitative Biology - Quantitative Methods
Abstract

Neuroscience research has expanded dramatically over the past 30 years by advancing standardization and tool development to support rigor and transparency. Consequently, the complexity of the data pipeline has also increased, hindering access to FAIR (Findable, Accessible, Interoperabile, and Reusable) data analysis to portions of the worldwide research community. brainlife.io was developed to reduce these burdens and democratize modern neuroscience research across institutions and career levels. Using community software and hardware infrastructure, the platform provides open-source data standardization, management, visualization, and processing and simplifies the data pipeline. brainlife.io automatically tracks the provenance history of thousands of data objects, supporting simplicity, efficiency, and transparency in neuroscience research. Here brainlife.io's technology and data services are described and evaluated for validity, reliability, reproducibility, replicability, and scientific utility. Using data from 4 modalities and 3,200 participants, we demonstrate that brainlife.io's services produce outputs that adhere to best practices in modern neuroscience research.

Published
2023
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3. Author Correction: brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Author

Hayashi, Soichi, Caron, Bradley A., Heinsfeld, Anibal Sólon, Vinci-Booher, Sophia, McPherson, Brent, Bullock, Daniel N., Bertò, Giulia, Niso, Guiomar, Hanekamp, Sandra, Levitas, Daniel, Ray, Kimberly, MacKenzie, Anne, Avesani, Paolo, Kitchell, Lindsey, Leong, Josiah K., Nascimento-Silva, Filipi, Koudoro, Serge, Willis, Hanna, Jolly, Jasleen K., Pisner, Derek, Zuidema, Taylor R., Kurzawski, Jan W., Mikellidou, Kyriaki, Bussalb, Aurore, Chaumon, Maximilien, George, Nathalie, Rorden, Christopher, Victory, Conner, Bhatia, Dheeraj, Aydogan, Dogu Baran, Yeh, Fang-Cheng F., Delogu, Franco, Guaje, Javier, Veraart, Jelle, Fischer, Jeremy, Faskowitz, Joshua, Fabrega, Ricardo, Hunt, David, McKee, Shawn, Brown, Shawn T., Heyman, Stephanie, Iacovella, Vittorio, Mejia, Amanda F., Marinazzo, Daniele, Craddock, R. Cameron, Olivetti, Emanuale, Hanson, Jamie L., Garyfallidis, Eleftherios, Stanzione, Dan, Carson, James, Henschel, Robert, Hancock, David Y., Stewart, Craig A., Schnyer, David, Eke, Damian O., Poldrack, Russell A., Bollmann, Steffen, Stewart, Ashley, Bridge, Holly, Sani, Ilaria, Freiwald, Winrich A., Puce, Aina, Port, Nicholas L., and Pestilli, Franco

Published
2024
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9. brainlife.io : A decentralized and open source cloud platform to support neuroscience research.

Author

Hayashi S, Caron BA, Heinsfeld AS, Vinci-Booher S, McPherson B, Bullock DN, Bertò G, Niso G, Hanekamp S, Levitas D, Ray K, MacKenzie A, Kitchell L, Leong JK, Nascimento-Silva F, Koudoro S, Willis H, Jolly JK, Pisner D, Zuidema TR, Kurzawski JW, Mikellidou K, Bussalb A, Rorden C, Victory C, Bhatia D, Baran Aydogan D, Yeh FF, Delogu F, Guaje J, Veraart J, Bollman S, Stewart A, Fischer J, Faskowitz J, Chaumon M, Fabrega R, Hunt D, McKee S, Brown ST, Heyman S, Iacovella V, Mejia AF, Marinazzo D, Craddock RC, Olivetti E, Hanson JL, Avesani P, Garyfallidis E, Stanzione D, Carson J, Henschel R, Hancock DY, Stewart CA, Schnyer D, Eke DO, Poldrack RA, George N, Bridge H, Sani I, Freiwald WA, Puce A, Port NL, and Pestilli F

Abstract

Neuroscience research has expanded dramatically over the past 30 years by advancing standardization and tool development to support rigor and transparency. Consequently, the complexity of the data pipeline has also increased, hindering access to FAIR data analysis to portions of the worldwide research community. brainlife.io was developed to reduce these burdens and democratize modern neuroscience research across institutions and career levels. Using community software and hardware infrastructure, the platform provides open-source data standardization, management, visualization, and processing and simplifies the data pipeline. brainlife.io automatically tracks the provenance history of thousands of data objects, supporting simplicity, efficiency, and transparency in neuroscience research. Here brainlife.io's technology and data services are described and evaluated for validity, reliability, reproducibility, replicability, and scientific utility. Using data from 4 modalities and 3,200 participants, we demonstrate that brainlife.io's services produce outputs that adhere to best practices in modern neuroscience research., Competing Interests: Competing interests. The authors declare no competing financial interests.

Published
2023

10. The use of chemogenetic actuator ligands in nonhuman primate DREADDs-fMRI.

Author

Cushnie AK, Bullock DN, Manea AMG, Tang W, Zimmermann J, and Heilbronner SR

Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are engineered receptors that allow for genetically targeted, reversible manipulation of cellular activity via systemic drug administration. DREADD induced manipulations are initiated via the binding of an actuator ligand. Therefore, the use of DREADDs is contingent on the availability of actuator ligands. Actuator ligands low-dose clozapine (CLZ) and deschloroclozapine (DCZ) are highly selective for DREADDs, and, upon binding, induce physiological and behavioral changes in rodents and nonhuman primates (NHPs). Despite this reported specificity, both CLZ and DCZ have partial affinity for a variety of endogenous receptors and can induce dose-specific changes even in naïve animals. As such, this study aimed to examine the effects of CLZ and DCZ on resting-state functional connectivity (rs-FC) and intrinsic neural timescales (INTs) in naïve NHPs. In doing so, we evaluated whether CLZ and DCZ - in the absence of DREADDs - are inert by examining these ligands' effects on the intrinsic functional properties of the brain. Low-dose DCZ did not induce consistent changes in rs-FC or INTs prior to the expression of DREADDs; however, a high dose resulted in subject-specific changes in rs-FC and INTs. In contrast, CLZ administration induced consistent changes in rs-FC and INTs prior to DREADD expression in our subjects. Our results caution against the use of CLZ by explicitly demonstrating the impact of off-target effects that can confound experimental results. Altogether, these data endorse the use of low dose DCZ for future DREADD-based experiments., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Published
2022
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