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2. Relationship between childhood trauma and level of insight in schizophrenia: A path-analysis in the national FACE-SZ dataset

Author

Andrianarisoa, M.D., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Pignon, Baptiste, Lajnef, Mohamed, Godin, Ophélia, Geoffray, Marie-Maud, Rey, Romain, Mallet, Jasmina, Dubertret, Caroline, Roux, Paul, Passerieux, Christine, Marulaz, Laurent, Brunel, Lore, Dubreucq, Julien, Leignier, Sylvain, Capdevielle, Delphine, André, Myrtille, Aouizerate, Bruno, Misdrahi, David, Berna, Fabrice, Vidailhet, Pierre, Chereau, Isabelle, Llorca, Pierre-Michel, Fond, Guillaume, Lançon, Christophe, Leboyer, Marion, and Schürhoff, Franck

Published
2019
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3. A multi-dimensional approach to the relationship between insight and aggressiveness in schizophrenia: Findings from the FACE-SZ cohort

Author

Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, L., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Norton, J., Raffard, S., Rey, R., Schurhoff, F., and Bonnet, S.

Published
2019
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4. Centres Experts Schizophrénie, un outil pour le soin et la recherche : retour sur 10 ans d’expérience

Author

Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Coulon, N., Danion, J.M., D’Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Jarroir, M., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Godin, O., Boyer, L., Chereau, I., and Lancon, C.

Published
2019
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5. Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Author

Fond, G, Godin, O, Schürhoff, F, Berna, F, Bulzacka, E, Andrianarisoa, M, Brunel, L, Aouizerate, B, Capdevielle, D, Chereau, I, Coulon, N, D'Amato, T, Dubertret, C, Dubreucq, J, Faget, C, Lançon, C, Leignier, S, Mallet, J, Misdrahi, D, Passerieux, C, Rey, R, Schandrin, A, Urbach, M, Vidailhet, P, Leboyer, M, Boyer, L, and Llorca, PM

Published
2018
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6. Psychiatric disability as mediator of the neurocognition-functioning link in schizophrenia spectrum disorders: SEM analysis using the Evaluation of Cognitive Processes involved in Disability in Schizophrenia (ECPDS) scale

Author

Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Roux, Paul, Urbach, Mathieu, Fonteneau, Sandrine, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubreucq, Julien, Faget-Agius, Catherine, Fond, Guillaume, Leignier, Sylvain, Perier, Claire-Cécile, Richieri, Raphaëlle, Schneider, Priscille, Schürhoff, Franck, Tronche, Anne-Marie, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, and Brunet-Gouet, Eric

Published
2018
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7. Latent toxoplasma infection in real-world schizophrenia: Results from the national FACE-SZ cohort

Author

Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Coulon, N., Danion, J.M., D'Amato, T., Deloge, A., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Jarroir, M., Leignier, S., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Boyer, L., Godin, O., and Chereau, I.

Published
2018
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8. Influence of Venus and Mars in the cognitive sky of schizophrenia. Results from the first-step national FACE-SZ cohort

Author

Andrianarisoa, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Boyer, L., Godin, O., Llorca, P.M., Chereau, I., Lancon, C., Roux, P., and Schürhoff, F.

Published
2018
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10. Towards an improved access to psychiatric rehabilitation: availability and effectiveness at 1-year follow-up of psychoeducation, cognitive remediation therapy, cognitive behaviour therapy and social skills training in the FondaMental Advanced Centers of Expertise-Schizophrenia (FACE-SZ) national cohort

Author

Dubreucq, Julien, Ycart, B., Gabayet, F., Perier, C. C., Hamon, A., Llorca, P. M., Boyer, L., Godin, O., Bulzacka, E., Andrianarisoa, M., Aouizerate, B., Berna, F., Brunel, L., Capdevielle, D., Chereau, I., D’Amato, T., Dubertret, C., Faget, C., Mallet, J., Misdrahi, D., Passerieux, C., Rey, R., Richieri, R., Schandrin, A., Schürhoff, F., Urbach, M., Vidailhet, P., Giraud-Baro, E., Fond, G., and FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group

Published
2019
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11. Predictors of rapid high weight gain in schizophrenia: Longitudinal analysis of the French FACE-SZ cohort

Author

Andrianarisoa, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilain, J., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Godin, O., Boyer, L., Richieri, R., and Costagliola, D.

Published
2017
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12. Cigarette smoking and schizophrenia: a specific clinical and therapeutic profile? Results from the FACE-Schizophrenia cohort

Author

Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Mazer, N., Chereau, I., and Roux, P.

Published
2017
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13. Childhood trauma, depression and negative symptoms are independently associated with impaired quality of life in schizophrenia. Results from the national FACE-SZ cohort

Author

Andrianarisoa, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Boyer, L., Godin, O., Richieri, R., and Schürhoff, F.

Published
2017
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14. Birth by cesarean section and schizophrenia: results from the multicenter FACE-SZ data-set

Author

Fond, G., Bulzacka, E., Boyer, L., Llorca, P. M., Godin, O., Brunel, L., Andrianarisoa, M. G., Aouizerate, B., Berna, F., Capdevielle, D., Chereau, I., Denizot, H., Dorey, J. M., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Le Strat, Y., Micoulaud-Franchi, J. A., Misdrahi, D., Rey, R., Richieri, R., Roger, M., Passerieux, C., Schandrin, A., Urbach, M., Vidalhet, P., Schürhoff, F., Leboyer, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J. M., D’Amato, T., Deloge, A., Delorme, C., Denizot, H., De Pradier, M., Dorey, J. M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M. C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P. M., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, A. M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., and FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Group

Published
2017
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15. Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort

Author

Fond, G., Resseguier, N., Schürhoff, F., Godin, O., Andrianarisoa, M., Brunel, L., Bulzacka, E., Aouizerate, B., Berna, F., Capdevielle, D., Chereau, I., D’Amato, T., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Lançon, C., Llorca, P. M., Mallet, J., Misdrahi, D., Passerieux, C., Rey, R., Schandrin, A., Urbach, M., Vidailhet, P., Boyer, L., Leboyer, M., and the FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group

Published
2018
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16. Peripheral sub-inflammation is associated with antidepressant consumption in schizophrenia. Results from the multi-center FACE-SZ data set

Author

Fond, G., Godin, O., Brunel, L., Aouizerate, B., Berna, F., Bulzacka, E., Capdevielle, D., Chereau, I., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Le Strat, Y., Micoulaud-Franchi, J.A., Misdrahi, D., Rey, R., Richieri, R., Passerieux, C., Schandrin, A., Schürhoff, F., Tronche, A.M., Urbach, M., Vidalhet, P., Llorca, P.M., and Leboyer, M.

Published
2016
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17. Akathisia: prevalence and risk factors in a community-dwelling sample of patients with schizophrenia. Results from the FACE-SZ dataset

Author

Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., De Pradier, M., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilain, J., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Boyer, L., Chereau, I., and Lancon, C.

Published
2015
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18. Metabolic syndrome, abdominal obesity and hyperuricemia in schizophrenia: Results from the FACE-SZ cohort

Author

Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Depradier, M., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Godin, O., Gaman, A., Chereau, I., Richieri, R., Vidalhet, P., and Girerd, N.

Published
2015
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20. Nicotine dependence is associated with depression and childhood trauma in smokers with schizophrenia: results from the FACE-SZ dataset

Author

Rey, Romain, D’Amato, Thierry, Boyer, Laurent, Brunel, Lore, Aouizerate, Bruno, Berna, Fabrice, Capdevielle, Delphine, Chereau, Isabelle, Chesnoy-Servanin, Gabrielle, Denizot, Hélène, Dorey, Jean-Michel, Dubertret, Caroline, Dubreucq, Julien, Faget, Catherine, Gabayet, Franck, Lancon, Christophe, Mallet, Jasmina, Misdrahi, David, Passerieux, Christine, Schandrin, Aurélie, Schürhoff, Franck, Urbach, Mathieu, Vidailhet, Pierre, Llorca, Pierre-Michel, Fond, Guillaume, Andrianarisoa, M., Andrianarisoa, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D’Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilain, J., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., and The FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group

Published
2017
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21. Benzodiazepine long-term administration is associated with impaired attention/working memory in schizophrenia: results from the national multicentre FACE-SZ data set

Author

Fond, Guillaume, Berna, F., Boyer, L., Godin, O., Brunel, L., Andrianarisoa, M., Aouizerate, B., Capdevielle, D., Chereau, I., Danion, J. M., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Le Gloahec, T., Llorca, P. M., Mallet, J., Misdrahi, D., Rey, R., Richieri, R., Passerieux, C., Portalier, C., Roux, P., Vehier, A., Yazbek, H., Schürhoff, F., Bulzacka, E., Andrianarisoa, Méja, Aouizerate, Bruno, Berna, Fabrice, Blanc, Olivier, Brunel, Lore, Bulzacka, Ewa, Capdevielle, Delphine, Chéreau-Boudet, Isabelle, Chesnoy-Servanin, Gabrielle, Danion, Jean-Marie, D’Amato, Thierry, Deloge, Arnaud, Delorme, Claire, Denizot, Hélène, Dorey, Jean-Michel, Dubertret, Caroline, Dubreucq, Julien, Faget, Catherine, Fluttaz, Cécile, Fond, Guillaume, Fonteneau, Sandrine, Gabayet, Franck, Giraud-Baro, Elisabeth, Hardy-Baylé, Marie-Christine, Lacelle, Delphine, Lançon, Christophe, Laouamri, Hakim, Leboyer, Marion, Le Gloahec, Tifenn, Le Strat, Yann, Llorca, Pierre-Michel, Mallet, Jasmina, Metairie, Emeline, Misdrahi, David, Offerlin-Meyer, Isabelle, Passerieux, Christine, Peri, Pauline, Pires, Sylvie, Portalier, Céline, Rey, Romain, Roman, Céline, Sebilleau, Mathilde, Schandrin, Aurélie, Schurhoff, Franck, Tessier, Arnaud, Tronche, Anne-Marie, Urbach, Mathieu, Vaillant, Florence, Vehier, Aurélie, Vidailhet, Pierre, Vilà, Estelle, Yazbek, Hanan, Zinetti-Bertschy, Anna, and The FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group

Published
2017
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23. Psychiatric and psychological follow-up of undergraduate and postgraduate medical students: prevalence and associated factors. Results from the national BOURBON study. Running title: mental health and addictive behavior of medical students

Author

Fond, Guillaume, Bulzacka, E., Boucekine, M., Schürhoff, F., Berna, F., Godin, O., Aouizerate, B., Chereau, I., d'Amato, T., Dubertret, C., Dubreucq, J., Faget, C., Leignier, S., Lançon, C., Mallet, J., Misdrahi, D., Passerieux, C., Rey, R., Schandrin, A., Urbach, M., Vidailhet, P., Leboyer, M., Boyer, L., Llorca, P.M., Aix Marseille Université (AMU), Assistance Publique-Hôpitaux de Marseille (AP-HM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Hospitalier le Vinatier [Bron], Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Génétique moléculaire de la neurotransmission et des processus neurodégénératifs (LGMNPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Image Science for Interventional Techniques (ISIT), and Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS)-Clermont Université

Subjects
health services administration, health care facilities, manpower, and services, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, education, health care economics and organizations, psychological phenomena and processes
Abstract

International audience; Background. Physicians are at risk of burnout, anxiety and depression. Prevention is

Published
2019
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24. The 10-year findings from the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ): Review and recommendations for clinical practice

Author

Godin, O., Boyer, L., Chereau, I., Andrianarisoa, M., Aouizerate, Bruno, Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Coulon, N., Danion, J.M., D’Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Jarroir, M., Lacelle, D., Lancon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vila, E., Vidailhet, P., Yazbek, H., Zinetti-Bertschy, A., Fondation FondaMental [Créteil], Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Université de Strasbourg (UNISTRA), Institut Européen des membranes (IEM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS)-Clermont Université, Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)

Subjects
Expert centre, Inflammation, Treatment, Cognition, Depression, [SDV]Life Sciences [q-bio], Schizophrenia, Metabolic syndrome
Abstract

International audience; Objectives - The present article is a synthesis of the first 10 years of follow-up of the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ) cohort. Methods - More than 700 community-dwelling stabilized subjects have been recruited and evaluated to date. The mean age was 32 years with 75 % males, the mean illness duration was 11 years, the mean age at illness onset was 21 years, the mean duration of untreated psychosis was 1.5 years and 55 % were current daily tobacco smokers. Results - The major findings of the FACE-SZ cohort may be summarized as follows: the metabolic syndrome is twice more frequent in schizophrenia as compared to the general population and is not correctly assessed and treated; cognitive disturbances have been found in benzodiazepine consumers and in patients with chronic low-grade peripheral inflammation; major depressive disorder (MDD) is a common current comorbid condition in about 20% of the subjects at the evaluation. MDD is associated with impaired quality of life and with increased nicotine dependency in SZ daily tobacco smokers. Improving depression and negative symptoms may be the most effective strategies to improve quality of life in schizophrenia; the duration of untreated psychosis is much longer in cannabis smokers and in subjects with an age at illness onset

Published
2019
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25. Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset

Author

Andrianarisoa, M., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Boyer, L., Godin, O., Coulon, N., Richieri, R., Roux, P., and Schürhoff, F.

Published
2018
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26. Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort. SHORT COMMUNICATION Running title: peripheral inflammation is associated with ultraresistant schizophrenia

Author

Fond, Guillaume, Godin, O., Boyer, L., Berna, F., Andrianarisoa, M., Coulon, N., Brunel, L., Bulzacka, E., Aouizerate, Bruno, Capdevielle, D., Chereau, I., D’Amato, T., Dubertret, C., Dubreucq, J., Faget, C., Leignier, S., Lançon, C., Mallet, J., Misdrahi, D., Passerieux, C., Rey, R., Schandrin, A., Urbach, M., Vidailhet, P., Llorca, P., Schürhoff, F., Leboyer, M., Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Fondation FondaMental [Créteil], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18) (Inserm U955), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Strasbourg (UNISTRA), Université de Bordeaux (UB), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère], Centre Hospitalier Alpes Isère, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010), Assistance Publique-Hôpitaux de Marseille (AP-HM), Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), and Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique

Subjects
Inflammation, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Functioning, Resistant schizophrenia
Abstract

International audience; A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia. Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment, including recording of current treatment. Current psychotic symptomatology was evaluated by the Positive and Negative Syndrome scale for Schizophrenia (PANSS). UTRS was defined by current clozapine treatment + PANSS total score ≥ 70. Functioning was evaluated by the Global Assessment of Functioning scale. High sensitivity CRP (hs-CRP) was measured for each participant as a proxy to define peripheral low-grade inflammation. 609 stabilized community-dwelling SZ subjects (mean age = 32.5 years, 73.6% male gender) have been included. 60 (9.9%) patients were classified in the UTRS group. In multivariate analyses, UTRS has been associated independently with chronic peripheral inflammation (OR = 2.6 [1.2–5.7], p = 0.01), illness duration (0R = 1.1 [1.0–1.2], p = 0.02) and impaired functioning (OR = 0.9 [0.9–0.9], p = 0.0002) after adjustment for age, sex, current daily tobacco smoking, metabolic syndrome and antidepressant consumption. Peripheral low-grade inflammation is associated with UTRS. Future studies should explore if anti-inflammatory strategies are effective in UTRS with chronic low-grade peripheral inflammation.

Published
2018
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27. Latent toxoplasma infection in real-world schizophrenia: Results from the national FACE-SZ cohort

Author

Fond , G., Boyer , L., Schürhoff , F., Berna , F., Godin , O., Bulzacka , E., Andrianarisoa , M., Brunel , L., Aouizerate , B., Capdevielle , D., Chereau , I., Coulon , N., d'Amato , T., Dubertret , C., Dubreucq , J., Faget , C., Lançon , C., Leignier , S., Mallet , J., Misdrahi , D., Passerieux , C., Rey , R., Schandrin , A., Urbach , M., Vidailhet , P., Llorca , P., Leboyer , M., Bazin , N., Blanc , O., Chereau-Boudet , I., Chesnoy-Servanin , G., Danion , M., Deloge , A., Denizot , H., Dorey , M., Fluttaz , C., Fonteneau , S., Gabayet , F., Giraud-Baro , E., Jarroir , M., Lacelle , D., Laouamri , H., Le Gloahec , T., Le Strat , Y., Metairie , E., Offerlin-Meyer , I., Peri , P., Pires , S., Portalier , C., Ramet , L., Roman , C., Tessier , A., Tronche , A., Vaillant , F., Vehier , A., Vila , E., Yazbek , H., Zinetti-Bertschy , A., CHU Pontchaillou [Rennes], Fondation FondaMental [Créteil], Institut Mondor de Recherche Biomédicale ( IMRB ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Institut Européen des membranes ( IEM ), Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Chimie de Montpellier ( ENSCM ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), Université Montpellier 1 ( UM1 ), Institut d'Electronique et de Télécommunications de Rennes ( IETR ), Université de Nantes ( UN ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National des Sciences Appliquées - Rennes ( INSA Rennes ) -CentraleSupélec-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier le Vinatier [Bron], Departement de Psychiatrie, Hôpital de la Conception [CHU - APHM] ( LA CONCEPTION ), Génétique moléculaire de la neurotransmission et des processus neurodégénératifs ( LGMNPN ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), ONERA - The French Aerospace Lab ( Toulouse ), ONERA, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne ( NPsy-Sydo ), CHU Clermont-Ferrand-Université Clermont Auvergne ( UCA ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies ( FEMTO-ST ), Université de Technologie de Belfort-Montbeliard ( UTBM ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Département des maladies infectieuses, Institut de Veille Sanitaire (INVS), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Techniques of Informatics and Microelectronics for integrated systems Architecture ( TIMA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Centre Hospitalier d'Annecy, Centre hospitalier d'Annecy, IHU-LIRYC, and Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]

Subjects
[ SDV.NEU.PC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [ SCCO.NEUR ] Cognitive science/Neuroscience, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018
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28. Relationship between childhood trauma and level of insight in schizophrenia: A path-analysis in the national FACE-SZ dataset

Author

Pignon, Baptiste, primary, Lajnef, Mohamed, additional, Godin, Ophélia, additional, Geoffray, Marie-Maud, additional, Rey, Romain, additional, Mallet, Jasmina, additional, Dubertret, Caroline, additional, Roux, Paul, additional, Passerieux, Christine, additional, Marulaz, Laurent, additional, Brunel, Lore, additional, Dubreucq, Julien, additional, Leignier, Sylvain, additional, Capdevielle, Delphine, additional, André, Myrtille, additional, Aouizerate, Bruno, additional, Misdrahi, David, additional, Berna, Fabrice, additional, Vidailhet, Pierre, additional, Chereau, Isabelle, additional, Llorca, Pierre-Michel, additional, Fond, Guillaume, additional, Lançon, Christophe, additional, Leboyer, Marion, additional, Schürhoff, Franck, additional, Andrianarisoa, M.D., additional, Aouizerate, B., additional, Berna, F., additional, Blanc, O., additional, Brunel, L., additional, Bulzacka, E., additional, Capdevielle, D., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, Danion, Jm, additional, D'Amato, T., additional, Deloge, A., additional, Delorme, C., additional, Denizot, H., additional, Dorey, J.M., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Fluttaz, C., additional, Fond, G., additional, Fonteneau, S., additional, Gabayet, F., additional, Giraud-Baro, E., additional, Hardy-Bayle, M.C., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Leboyer, M., additional, Le Gloahec, T., additional, Le Strat, Y., additional, Llorca, P.M., additional, Mallet, J., additional, Metairie, E., additional, Misdrahi, D., additional, Offerlin-Meyer, I., additional, Passerieux, C., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Rey, R., additional, Roman, C., additional, Sebilleau, M., additional, Schandrin, A., additional, Schurhoff, F., additional, Tessier, A., additional, Tronche, Am, additional, Urbach, M., additional, Vaillant, F., additional, Vehier, A., additional, Vidailhet, P., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2019
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29. Centres Experts Schizophrénie, un outil pour le soin et la recherche : retour sur 10 ans d’expérience

Author

Schürhoff, F., primary, Fond, G., additional, Berna, F., additional, Bulzacka, E., additional, Godin, O., additional, Boyer, L., additional, Misdrahi, D., additional, Andrianarisoa, M., additional, Brunel, L., additional, Coulon, N., additional, Aouizerate, B., additional, Capdevielle, D., additional, Chereau, I., additional, D’Amato, T., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Gabayet, F., additional, Mallet, J., additional, Rey, R., additional, Lancon, C., additional, Passerieux, C., additional, Schandrin, A., additional, Urbach, M., additional, Vidailhet, P., additional, Leboyer, M., additional, Llorca, P.M., additional, Bazin, N., additional, Blanc, O., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, Danion, J.M., additional, Deloge, A., additional, Delorme, C., additional, Denizot, H., additional, Dorey, J.M., additional, Fluttaz, C., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Jarroir, M., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Le Gloahec, T., additional, Le Strat, Y., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Ramet, L., additional, Roman, C., additional, Schürhoff, F., additional, Tessier, A., additional, Tronche, A.M., additional, Vaillant, F., additional, Vehier, A., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2019
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30. A multi-dimensional approach to the relationship between insight and aggressiveness in schizophrenia: Findings from the FACE-SZ cohort

Author

Schandrin, A., primary, Norton, J., additional, Raffard, S., additional, Aouizerate, B., additional, Berna, F., additional, Brunel, L., additional, Chereau-Boudet, I., additional, D'Amato, T., additional, Denizot, H., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Fond, G., additional, Gabayet, F., additional, Llorca, P.M., additional, Mallet, J., additional, Misdrahi, D., additional, Passerieux, C., additional, Rey, R., additional, Schurhoff, F., additional, Urbach, M., additional, Bonnet, S., additional, Capdevielle, D., additional, Andrianarisoa, M., additional, Bazin, N., additional, Blanc, O., additional, Bulzacka, E., additional, Chesnoy-Servanin, G., additional, Danion, J.M., additional, Deloge, A., additional, Delorme, C., additional, Dorey, J.M., additional, Fluttaz, C., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Leboyer, M., additional, Le Gloahec, T., additional, Le Strat, Y., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Ramet, L., additional, Rey, L., additional, Roman, C., additional, Schandrin, A., additional, Schürhoff, F., additional, Tessier, A., additional, Tronche, A.M., additional, Vaillant, F., additional, Vehier, A., additional, Vidailhet, P., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2019
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31. Centres Experts Schizophrénie, un outil pour le soin et la recherche : retour sur 10 ans d’expérience

Author

Schürhoff, F., Fond, G., Berna, F., Bulzacka, E., Godin, O., Boyer, L., Misdrahi, D., Andrianarisoa, M., Brunel, L., Coulon, N., Aouizerate, B., Capdevielle, D., Chereau, I., D’Amato, T., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Mallet, J., Rey, R., Lancon, C., Passerieux, C., Schandrin, A., Urbach, M., Vidailhet, P., Leboyer, M., Llorca, P.M., Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Coulon, N., Danion, J.M., D’Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Jarroir, M., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, A.M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., and Zinetti-Bertschy, A.

Abstract

Le présent article propose de faire un retour sur les 10 ans d’expérience du réseau national des 10 centres experts schizophrénie Français, à travers une revue des principales publications scientifiques qui en sont issues.

Published
2024
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32. Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset

Author

Fond, G., primary, Boyer, L., additional, Andrianarisoa, M., additional, Godin, O., additional, Brunel, L., additional, Bulzacka, E., additional, Coulon, N., additional, Llorca, P.M., additional, Berna, F., additional, Aouizerate, B., additional, Capdevielle, D., additional, D'Amato, T., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Gabayet, F., additional, Mallet, J., additional, Misdrahi, D., additional, Rey, R., additional, Richieri, R., additional, Roux, P., additional, Passerieux, C., additional, Schandrin, A., additional, Tronche, A.M., additional, Vidailhet, P., additional, Leboyer, M., additional, Schürhoff, F., additional, Blanc, O., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, Danion, J.M., additional, Deloge, A., additional, Delorme, C., additional, Denizot, H., additional, Dorey, J.M., additional, Fluttaz, C., additional, Fond, G., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Hardy-Bayle, M.C., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Le Gloahec, T., additional, Le Strat, Y., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Roman, C., additional, Sebilleau, M., additional, Schurhoff, F., additional, Tessier, A., additional, Urbach, M., additional, Vaillant, F., additional, Vehier, A., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2018
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33. Predictors of rapid high weight gain in schizophrenia: Longitudinal analysis of the French FACE-SZ cohort

Author

Godin, O., primary, Leboyer, M., additional, Schürhoff, F., additional, Boyer, L., additional, Andrianarisoa, M., additional, Brunel, L., additional, Bulzacka, E., additional, Aouizerate, B., additional, Berna, F., additional, Capdevielle, D., additional, D'Amato, T., additional, Denizot, H., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Gabayet, F., additional, Llorca, P.M., additional, Mallet, J., additional, Misdrahi, D., additional, Passerieux, C., additional, Rey, R., additional, Richieri, R., additional, Schandrin, A., additional, Urbach, M., additional, Vidailhet, P., additional, Costagliola, D., additional, Fond, G., additional, Blanc, O., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, Danion, J.M., additional, Deloge, A., additional, Delorme, C., additional, Dorey, J.M., additional, Fluttaz, C., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Hardy-Bayle, M.C., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Le Gloahec, T., additional, Le Strat, Y., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Roman, C., additional, Sebilleau, M., additional, Tessier, A., additional, Tronche, A.M., additional, Vaillant, F., additional, Vehier, A., additional, Vilain, J., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2017
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34. Cigarette smoking and schizophrenia: a specific clinical and therapeutic profile? Results from the FACE-Schizophrenia cohort

Author

Mallet, J., primary, Le Strat, Y., additional, Schürhoff, F., additional, Mazer, N., additional, Portalier, C., additional, Andrianarisoa, M., additional, Aouizerate, B., additional, Berna, F., additional, Brunel, L., additional, Capdevielle, D., additional, Chereau, I., additional, D'Amato, T., additional, Denizot, H., additional, Dubreucq, J., additional, Faget, C., additional, Gabayet, F., additional, Lançon, C., additional, Llorca, P.M., additional, Misdrahi, D., additional, Rey, R., additional, Roux, P., additional, Schandrin, A., additional, Urbach, M., additional, Vidailhet, P., additional, Fond, G., additional, Dubertret, C., additional, Bazin, N., additional, Blanc, O., additional, Bulzacka, E., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, Danion, J.M., additional, Deloge, A., additional, Delorme, C., additional, Dorey, J.M., additional, Fluttaz, C., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Lacelle, D., additional, Laouamri, H., additional, Leboyer, M., additional, Le Gloahec, T., additional, Mallet, J., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Passerieux, C., additional, Peri, P., additional, Pires, S., additional, Ramet, L., additional, Roman, C., additional, Tessier, A., additional, Tronche, A.M., additional, Vaillant, F., additional, Vehier, A., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2017
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35. The World Health Organization (WHO) dataset for guiding suicide prevention policies: A 3-decade French national survey

Author

Godin, O., Gaman, A., Richieri, R., Vidalhet, P., Girerd, N., Aouizerate, B., Berna, F., Blanc, O., Bulzacka, E., Capdevielle, D., Chereau, I., Chesnoy-Servanin, G., Danion, M., d'Amato, T., Deloge, A., Delorme, C., Denizot, H., Depradier, M., Dorey, M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M., Lacelle, D., Lancon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, M., Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vila, E., Yazbek, H., Zinetti-Bertschy, A., de Chazeron, I., Pereira, B., Chéreau-Boudet, I., Durif, F., Lemaire, J., Brousse, B., Ulla, M., Derost, P., Debilly, B., Llorca, M., Fond, Guillaume, Zendjidjian, Xavier, Boucekine, Mohamed, Brunel, Lore, Llorca, Pierre-Michel, Boyer, Laurent, Fondation FondaMental [Créteil], Departement de Psychiatrie, Hôpital de la Conception [CHU - APHM] (LA CONCEPTION ), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Montpellier 1 (UM1), Centre Hospitalier le Vinatier [Bron], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Hopital Louis Mourier - AP-HP [Colombes], Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ONERA - The French Aerospace Lab [Toulouse], ONERA, Centre Hospitalier d'Annecy, Centre hospitalier d'Annecy, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Biostatistiques, Inferential, Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Université d'Auvergne - Clermont-Ferrand I (UdA), Assistance Publique - Hôpitaux de Marseille (APHM), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Laboratoire de l'intégration, du matériau au système (IMS), Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)

Subjects
Gerontology, Male, Suicide Prevention, medicine.medical_specialty, Time Factors, Adolescent, Databases, Factual, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Population, Poison control, World Health Organization, Suicide prevention, Sex Factors, Surveys and Questionnaires, Health care, Medicine, Humans, Mortality, education, Health policy, ComputingMilieux_MISCELLANEOUS, Aged, education.field_of_study, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, Mortality rate, Public health, Health Policy, [SCCO.NEUR]Cognitive science/Neuroscience, Age Factors, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Middle Aged, Psychiatry and Mental health, Clinical Psychology, Suicide, Health promotion, Socioeconomic Factors, Female, France, business, Demography
Abstract

Background Public health policies aim to prevent suicide in the general population. Assessing their effectiveness is required to further guide public health policies. The present article focuses on the French paradox. The French health care system was classified as the best in the world according the World Health Organization (WHO). However, suicide rates in France remain high compared to other European countries. The aim of the present article was to analyze (i) the evolution of suicide Age-Standardized Death (ASDRs) in France during the last three decades and the associations with socio-economic parameters and (ii) to understand which populations may specifically benefit from further targeted suicide prevention policies. Methods The database of the World Health Organization (WHO), freely available, was explored in April 2015. ASDRs were calculated each year by ratio between the number of deaths by suicide and the total population (per 100,000 inhabitants). Number of deaths by gender and age were also analyzed. Results Overall, ASDR suicide has decreased since 1987 in France (−32.8% between 1987 and 2010). However, France kept the same rank (10/26) when compared to other European countries between 1987 and 2010. The relative burden of suicide in all-causes mortality increased during the same period (+28.2%) while the total number of deaths by suicide increased only slightly (+3.9%). More specifically, the number of deaths by suicide increased substantially in [35–54] years old (+40%) and 75+ years old (+27%) males, and in [35–54] (+41%) years old females. Between 2000 and 2010, suicide rates significantly decreased when yearly mean income increased, and when general and psychiatric care beds decreased. Conclusion Although ASDR suicide has decreased in France since 1987, this decline is quite modest when considering its universal access to care, the prevention of depression and suicide public policies. Suicide prevention public policies should focus on evaluation and improvement of prevention and care in the [35–54] years old population, and in the males aged 75+.

Published
2015
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36. A National network of schizophrenia expert centres: An innovative tool to bridge the research-practice gap

Author

Brousse, Georges, Bendimerad, Patrick, De Chazeron, Ingrid, Llorca, Pierre, Perney, Pascal, Dematteis, Maurice, Schürhoff, F., Fond, G., Berna, F., Bulzacka, E., Vilain, J., Capdevielle, D., Misdrahi, D., Leboyer, M., Llorca, M., Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), Université Clermont Auvergne (UCA)-CHU Clermont-Ferrand, CH La Rochelle, Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques (CARRTEL), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de la Recherche Agronomique (INRA), Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation FondaMental [Créteil], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Montpellier 1 (UM1), CHU Strasbourg, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Bordeaux [Bordeaux], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), roussel, pascale, and CHU Clermont-Ferrand-Université Clermont Auvergne (UCA)

Subjects
[SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Schizophrenia (object-oriented programming), Network, Translational research, Guideline, Bridge (nautical), Expert centre, Translational Research, Biomedical, 03 medical and health sciences, Health services, 0302 clinical medicine, Nursing, Medicine, Web application, Humans, Set (psychology), Expert Testimony, ComputingMilieux_MISCELLANEOUS, Medical education, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 3. Good health, 030227 psychiatry, Patient Care Management, [SDV] Life Sciences [q-bio], Psychiatry and Mental health, Models, Organizational, Schizophrenia, Observational study, Interdisciplinary Communication, France, business, 030217 neurology & neurosurgery
Abstract

Schizophrenia is probably the most severe psychiatric disorder with much suffering for the patients and huge costs for the society. Efforts to provide optimal care by general practitioners and psychiatrists are undermined by the complexity of the disorder and difficulties in applying clinical practice guidelines and new research findings to the spectrum of cases seen in day-to-day practice. An innovative model of assessment aimed at improving global care of people with schizophrenia provided by the French national network of schizophrenia expert centres is being described. Each centre has established strong links to local health services and provides support to clinicians in delivering personalized care plans. A common set of assessment tools has been adopted by the ten centres spread over the whole French territory. A web application, e-schizo©has been created to record data in a common computerized medical file. This network offers systematic, comprehensive, longitudinal, and multi-dimensional assessments of cases including a medical workup and an exhaustive neuropsychological evaluation. This strategy offers an effective way to transfer knowledge and share expertise. This network is a great opportunity to improve the global patient care and is conceived as being an infrastructure for research from observational cohort to translational research.

Published
2015
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37. Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort.

Author

Fond, G., Godin, O., Boyer, L., Berna, F., Andrianarisoa, M., Coulon, N., Brunel, L., Bulzacka, E., Aouizerate, B., Capdevielle, D., Chereau, I., D'Amato, T., Dubertret, C., Dubreucq, J., Faget, C., Leignier, S., Lançon, C., Mallet, J., Misdrahi, D., and Passerieux, C.

Subjects
SCHIZOPHRENIA, INFLAMMATION, ANTIPSYCHOTIC agents, TOBACCO smoke, METABOLIC syndrome
Abstract

A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia. Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment, including recording of current treatment. Current psychotic symptomatology was evaluated by the Positive and Negative Syndrome scale for Schizophrenia (PANSS). UTRS was defined by current clozapine treatment + PANSS total score ≥ 70. Functioning was evaluated by the Global Assessment of Functioning scale. High sensitivity CRP (hs-CRP) was measured for each participant as a proxy to define peripheral low-grade inflammation. 609 stabilized community-dwelling SZ subjects (mean age = 32.5 years, 73.6% male gender) have been included. 60 (9.9%) patients were classified in the UTRS group. In multivariate analyses, UTRS has been associated independently with chronic peripheral inflammation (OR = 2.6 [1.2–5.7], p = 0.01), illness duration (0R = 1.1 [1.0–1.2], p = 0.02) and impaired functioning (OR = 0.9 [0.9–0.9], p = 0.0002) after adjustment for age, sex, current daily tobacco smoking, metabolic syndrome and antidepressant consumption. Peripheral low-grade inflammation is associated with UTRS. Future studies should explore if anti-inflammatory strategies are effective in UTRS with chronic low-grade peripheral inflammation. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Identifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations

Author

Van Os, J. Rutten, B.P. Myin-Germeys, I. Delespaul, P. Viechtbauer, W. Van Zelst, C. Bruggeman, R. Reininghaus, U. Morgan, C. Murray, R.M. Di Forti, M. McGuire, P. Valmaggia, L.R. Kempton, M.J. Gayer-Anderson, C. Hubbard, K. Beards, S. Stilo, S.A. Onyejiaka, A. Bourque, F. Modinos, G. Tognin, S. Calem, M. O'Donovan, M.C. Owen, M.J. Holmans, P. Williams, N. Craddock, N. Richards, A. Humphreys, I. Meyer-Lindenberg, A. Leweke, F.M. Tost, H. Akdeniz, C. Rohleder, C. Bumb, J.M. Schwarz, E. Alptekin, K. Üçok, A. Saka, M.C. Atbagoǧlu, E.C. Gülöksüz, S. Gumus-Akay, G. Cihan, B. Karadaǧ, H. Soygür, H. Cankurtaran, E.S. Ulusoy, S. Akdede, B. Binbay, T. Ayer, A. Noyan, H. Karadayi, G. Akturan, E. Ulaş, H. Arango, C. Parellada, M. Bernardo, M. Sanjuán, J. Bobes, J. Arrojo, M. Santos, J.L. Cuadrado, P. Solano, J.J.R. Carracedo, A. Bernardo, E.G. Roldán, L. López, G. Cabrera, B. Cruz, S. Mesa, E.M.D. Pouso, M. Jiménez, E. Sánchez, T. Rapado, M. González, E. Martínez, C. Sánchez, E. Olmeda, M.S. De Haan, L. Velthorst, E. Van Der Gaag, M. Selten, J.-P. Van Dam, D. Van Der Ven, E. Van Der Meer, F. Messchaert, E. Kraan, T. Burger, N. Leboyer, M. Szoke, A. Schürhoff, F. Llorca, P.-M. Jamain, S. Tortelli, A. Frijda, F. Vilain, J. Galliot, A.-M. Baudin, G. Ferchiou, A. Richard, J.-R. Bulzacka, E. Charpeaud, T. Tronche, A.-M. De Hert, M. Van Winkel, R. Decoster, J. Derom, C. Thiery, E. Stefanis, N.C. Sachs, G. Aschauer, H. Lasser, I. Winklbaur, B. Schlögelhofer, M. Riecher-Rössler, A. Borgwardt, S. Walter, A. Harrisberger, F. Smieskova, R. Rapp, C. Ittig, S. Soguel-Dit-Piquard, F. Studerus, E. Klosterkötter, J. Ruhrmann, S. Paruch, J. Julkowski, D. Hilboll, D. Sham, P.C. Cherny, S.S. Chen, E.Y.H. Campbell, D.D. Li, M. Romeo-Casabona, C.M. Cirión, A.E. Mora, A.U. Jones, P. Kirkbride, J. Cannon, M. Rujescu, D. Tarricone, I. Berardi, D. Bonora, E. Seri, M. Marcacci, T. Chiri, L. Chierzi, F. Storbini, V. Braca, M. Minenna, M.G. Donegani, I. Fioritti, A. La Barbera, D. La Cascia, C.E. Mulè, A. Sideli, L. Sartorio, R. Ferraro, L. Tripoli, G. Seminerio, F. Marinaro, A.M. McGorry, P. Nelson, B. Amminger, G.P. Pantelis, C. Menezes, P.R. Del-Ben, C.M. Tenan, S.H.G. Shuhama, R. Ruggeri, M. Tosato, S. Lasalvia, A. Bonetto, C. Ira, E. Nordentoft, M. Krebs, M.-O. Barrantes-Vidal, N. Cristóbal, P. Kwapil, T.R. Brietzke, E. Bressan, R.A. Gadelha, A. Maric, N.P. Andric, S. Mihaljevic, M. Mirjanic, T.

Abstract

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © 2014 The Author.

Published
2014

41. Akathisia: prevalence and risk factors in a community-dwelling sample of patients with schizophrenia. Results from the FACE-SZ dataset

Author

Berna, F., primary, Misdrahi, D., additional, Boyer, L., additional, Aouizerate, B., additional, Brunel, L., additional, Capdevielle, D., additional, Chereau, I., additional, Danion, J.M., additional, Dorey, J.M., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Gabayet, F., additional, Lancon, C., additional, Mallet, J., additional, Rey, R., additional, Passerieux, C., additional, Schandrin, A., additional, Schurhoff, F., additional, Tronche, A.M., additional, Urbach, M., additional, Vidailhet, P., additional, Llorca, P.M., additional, Fond, G., additional, Berna, F., additional, Blanc, O., additional, Bulzacka, E., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, D'Amato, T., additional, Deloge, A., additional, Delorme, C., additional, Denizot, H., additional, De Pradier, M., additional, Fluttaz, C., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Hardy-Bayle, M.C., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Leboyer, M., additional, Le Gloahec, T., additional, Le Strat, Y., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Roman, C., additional, Sebilleau, M., additional, Tessier, A., additional, Vaillant, F., additional, Vehier, A., additional, Vilain, J., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2015
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42. Metabolic syndrome, abdominal obesity and hyperuricemia in schizophrenia: Results from the FACE-SZ cohort

Author

Godin, O., primary, Leboyer, M., additional, Gaman, A., additional, Aouizerate, B., additional, Berna, F., additional, Brunel, L., additional, Capdevielle, D., additional, Chereau, I., additional, Dorey, J.M., additional, Dubertret, C., additional, Dubreucq, J., additional, Faget, C., additional, Gabayet, F., additional, Le Strat, Y., additional, Llorca, P.M., additional, Misdrahi, D., additional, Rey, R., additional, Richieri, R., additional, Passerieux, C., additional, Schandrin, A., additional, Schürhoff, F., additional, Urbach, M., additional, Vidalhet, P., additional, Girerd, N., additional, Fond, G., additional, Blanc, O., additional, Bulzacka, E., additional, Chereau-Boudet, I., additional, Chesnoy-Servanin, G., additional, Danion, J.M., additional, D'Amato, T., additional, Deloge, A., additional, Delorme, C., additional, Denizot, H., additional, Depradier, M., additional, Fluttaz, C., additional, Fonteneau, S., additional, Giraud-Baro, E., additional, Hardy-Bayle, M.C., additional, Lacelle, D., additional, Lançon, C., additional, Laouamri, H., additional, Le Gloahec, T., additional, Metairie, E., additional, Offerlin-Meyer, I., additional, Peri, P., additional, Pires, S., additional, Portalier, C., additional, Roman, C., additional, Sebilleau, M., additional, Tessier, A., additional, Tronche, A.M., additional, Vaillant, F., additional, Vehier, A., additional, Vidailhet, P., additional, Vilà, E., additional, Yazbek, H., additional, and Zinetti-Bertschy, A., additional

Published
2015
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47. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations

Author

Rosana Shuhama, Gonzalo López, Viviana Storbini, Tolga Binbay, Ma Soledad Olmeda, Maria Calem, Marina Mihaljevic, Christos Pantelis, Halis Ulaş, Eva Velthorst, Jeroen Decoster, J. Malte Bumb, Ruud van Winkel, E. Cem Atbasoglu, Wolfgang Viechtbauer, Mirella Ruggeri, Erich Studerus, Daniele La Barbera, Domenico Berardi, Anita Riecher-Rössler, Stefan Borgwardt, Elsje van der Ven, Charlotte Rapp, Desiree Hilboll, Mark van der Gaag, Chiara Bonetto, Marie-Odile Krebs, Silvia Tenan, Monika Schlögelhofer, Robin M. Murray, Caterina La Cascia, Philip McGuire, Simona A. Stilo, Desmond Campbell, Fabienne Harrisberger, Teresa Sánchez, Catherine Derom, Franck Schürhoff, Philippe Delespaul, Jose Luis Santos, Emilio Sánchez, Stephan Ruhrmann, Luigi Rocco Chiri, Sabrina Cruz, Handan Noyan, Dominika Julkowski, Celso Arango, Merete Nordentoft, Stacey S. Cherny, Anne-Marie Galliot, Daniella van Dam, María Pouso, Asier Urruela Mora, G. Paul Amminger, Enrique García Bernardo, Ahmet Ayer, Tijana Mirjanic, Andrei Szöke, Anna Walter, Antonio Lasalvia, Isla Humphreys, Flora Frijda, Lieuwe de Haan, Neus Barrantes-Vidal, Nigel Williams, Burçin Cihan, Matthew J. Kempton, Ceren Akdeniz, Tamar Kraan, Andrea Tortelli, Barnaby Nelson, Marta Di Forti, Angelo Fioritti, Pedro Cuadrado, Eylem Sahin Cankurtaran, Emanuel Schwarz, Andreas Meyer-Lindenberg, Ilaria Tarricone, Laura Ferraro, Dan Rujescu, Anne-Marie Tronche, Laura Roldan, Bibiana Cabrera, Alp Üçok, Craig Morgan, Julio Sanjuán, Mauro Braca, Julio Bobes, Eric Y.H. Chen, Michael Conlon O'Donovan, Peter Holmans, Harald N. Aschauer, Sarah Ittig, Covadonga Martínez, Iris Lasser, Emiliano González, Aitziber Emaldi Cirión, Rachele Sartorio, F. Seminerio, Rodrigo A. Bressan, Ulrich Reininghaus, Elisa Brietzke, François Bourque, G Tripoli, Inez Myin-Germeys, Aziz Ferchiou, Gemma Modinos, Grégoire Baudin, Fabienne Soguel-Dit-Piquard, Cristina Marta Del-Ben, Gabriele Sachs, Elçin Akturan, Manuel Arrojo, Thomas R. Kwapil, Alice Mulè, Eva Mª Díaz Mesa, Federico Chierzi, Köksal Alptekin, Floor J. van der Meer, Pak C. Sham, Jim van Os, Adanna Onyejiaka, Mara Parellada, Bart P. F. Rutten, Jeanne Vilain, Michael John Owen, Sarah Tosato, Haldan Soygür, A.M. Marinaro, Stefania Tognin, Evert Thiery, Cathrin Rohleder, Mary Cannon, Miaoxin Li, F. Markus Leweke, Marc De Hert, Marta Rapado, Maria Gabriella Minenna, Pierre-Michel Llorca, Alexander Richards, Stéphane Jamain, Elles Messchaert, Nadja P. Maric, Semra Ulusoy, Elisa Ira, Peter G. Jones, Paulo Rossi Menezes, Patrick D. McGorry, Bernadette Winklbaur, Stephanie Beards, Nadine Burger, Güvem Gümüş-Akay, Marion Leboyer, James B. Kirkbride, Sinan Guloksuz, Ary Gadelha, E. Bulzacka, Carlos M. Romeo-Casabona, Gülşah Karadayı, Jean-Paul Selten, José Juan Rodríguez Solano, Kathryn Hubbard, Estela Jiménez, Thomas Charpeaud, Nikos C. Stefanis, Lucia Sideli, Miguel Bernardo, Jean-Romain Richard, Ivonne Donegani, Marco Seri, Lucia Valmaggia, Julia Paruch, Catherine van Zelst, Meram Can Saka, Heike Tost, Renata Smieskova, Thomas Marcacci, Nicholas John Craddock, Berna Binnur Akdede, Joachim Klosterkötter, Richard Bruggeman, Charlotte Gayer-Anderson, Sanja Andric, Elena Bonora, Angel Carracedo, Hasan Karadağ, Paula Cristobal, ANS - Amsterdam Neuroscience, Adult Psychiatry, Graduate School, Perceptual and Cognitive Neuroscience (PCN), Maastricht Univ, Kings Coll London, Mondriaan Mental Hlth Trust, Univ Groningen, Cardiff Univ, Cent Inst Mental Hlth, Dokuz Eylul Univ, Istanbul Univ, Ankara Univ, Yale Univ, Middle E Tech Univ, Diskapi YB Res & Training Hosp, Turkish Federat Schizophrenia Assoc, Ataturk Training & Res Hosp, Manisa Mental Hlth Hosp, Univ Complutense, Univ Barcelona, Univ Valencia, Univ Oviedo, Univ Santiago de Compostela, Hosp Virgen de la Luz, Hosp Univ Infanta Leonor Hosp Virgen Torre, Hosp Clin Univ, Hosp Psiquiatr Conxo, Univ Amsterdam, Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Parnassia Psychiat Inst, Rivierduinen Psychiat Inst, Grp Hosp Mondor, Hop Henri Mondor, Univ Paris Est, Fdn Fondamental, CMP B CHU, Univ Auvergne, EPS Maison Blanche, UPC KU Leuven, UPC, Katholieke Univ Leuven, Assoc Sci Res Multiple Births, Univ Ghent, Univ Athens, Med Univ Vienna, Psychiat Univ Clin Basel, Univ Cologne, Univ Hong Kong, Univ Basque Country, Univ Zaragoza, Univ Cambridge, UCL, Royal Coll Surgeons Ireland, Univ Munich, Univ Bologna, Local Hlth Trust, Univ Palermo, P Giaccone Gen Hosp, Univ Melbourne, Universidade de São Paulo (USP), Univ Verona, Copenhagen Univ Hosp, Univ Paris 05, Univ Autonoma Barcelona, St Pere Claver Fundacio Sanitaria, Univ N Carolina, CIBERSAM, Universidade Federal de São Paulo (UNIFESP), Univ Belgrade, van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G, Cihan B, Karadağ H, Soygür H, Cankurtaran EŞ, Ulusoy S, Akdede B, Binbay T, Ayer A, Noyan H, Karadayı G, Akturan E, Ulaş H, Arango C, Parellada M, Bernardo M, Sanjuán J, Bobes J, Arrojo M, Santos JL, Cuadrado P, Rodríguez Solano JJ, Carracedo A, García Bernardo E, Roldán L, López G, Cabrera B, Cruz S, Díaz Mesa EM, Pouso M, Jiménez E, Sánchez T, Rapado M, González E, Martínez C, Sánchez E, Olmeda MS, de Haan L, Velthorst E, van der Gaag M, Selten JP, van Dam D, van der Ven E, van der Meer F, Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, Jamain S, Tortelli A, Frijda F, Vilain J, Galliot AM, Baudin G, Ferchiou A, Richard JR, Bulzacka E, Charpeaud T, Tronche AM, De Hert M, van Winkel R, Decoster J, Derom C, Thiery E, Stefanis NC, Sachs G, Aschauer H, Lasser I, Winklbaur B, Schlögelhofer M, Riecher-Rössler A, Borgwardt S, Walter A, Harrisberger F, Smieskova R, Rapp C, Ittig S, Soguel-dit-Piquard F, Studerus E, Klosterkötter J, Ruhrmann S, Paruch J, Julkowski D, Hilboll D, Sham PC, Cherny SS, Chen EY, Campbell DD, Li M, Romeo-Casabona CM, Emaldi Cirión A, Urruela Mora A, Jones P, Kirkbride J, Cannon M, Rujescu D, Tarricone I, Berardi D, Bonora E, Seri M, Marcacci T, Chiri L, Chierzi F, Storbini V, Braca M, Minenna MG, Donegani I, Fioritti A, La Barbera D, La Cascia CE, Mulè A, Sideli L, Sartorio R, Ferraro L, Tripoli G, Seminerio F, Marinaro AM, McGorry P, Nelson B, Amminger GP, Pantelis C, Menezes PR, Del-Ben CM, Gallo Tenan SH, Shuhama R, Ruggeri M, Tosato S, Lasalvia A, Bonetto C, Ira E, Nordentoft M, Krebs MO, Barrantes-Vidal N, Cristóbal P, Kwapil TR, Brietzke E, Bressan RA, Gadelha A, Maric NP, Andric S, Mihaljevic M, Mirjanic T, Clinical Psychology, EMGO+ - Mental Health, Van Os, J., Rutten, B., Myin Germeys, I., Delespaul, P., Viechtbauer, W., Van Zelst, C., Bruggeman, R., Reininghaus, U., Morgan, C., Murray, R., Di Forti, M., Mcguire, P., Valmaggia, L., Kempton, M., Gayer Anderson, C., Hubbard, K., Beards, S., Stilo, S., Onyejiaka, A., Bourque, F., Modinos, G., Tognin, S., Calem, M., O'Donovan, M., Owen, M., Holmans, P., Williams, N., Craddock, N., Richards, A., Humphreys, I., Meyer Lindenberg, A., Leweke, F., Tost, H., Akdeniz, C., Rohleder, C., Bumb, J., Schwarz, E., Alptekin, K., Üçok, A., Saka, M., Atbagoǧlu, E., Gülöksüz, S., Gumus Akay, G., Cihan, B., Karadaǧ, H., Soygür, H., Cankurtaran, E., Ulusoy, S., Akdede, B., Binbay, T., Ayer, A., Noyan, H., Karadayi, G., Akturan, E., Ulaş, H., Arango, C., Parellada, M., Bernardo, M., Sanjuán, J., Bobes, J., Arrojo, M., Santos, J., Cuadrado, P., Solano, J., Carracedo, A., Bernardo, E., Roldán, L., López, G., Cabrera, B., Cruz, S., Mesa, E., Pouso, M., Jiménez, E., Sánchez, T., Rapado, M., González, E., Martínez, C., Sánchez, E., Olmeda, M., De Haan, L., Velthorst, E., Van Der Gaag, M., Selten, J., Van Dam, D., Van Der Ven, E., Van Der Meer, F., Messchaert, E., Kraan, T., Burger, N., Leboyer, M., Szoke, A., Schürhoff, F., Llorca, P., Jamain, S., Tortelli, A., Frijda, F., Vilain, J., Galliot, A., Baudin, G., Ferchiou, A., Richard, J., Bulzacka, E., Charpeaud, T., Tronche, A., De Hert, M., Van Winkel, R., Decoster, J., Derom, C., Thiery, E., Stefanis, N., Sachs, G., Aschauer, H., Lasser, I., Winklbaur, B., Schlögelhofer, M., Riecher Rössler, A., Borgwardt, S., Walter, A., Harrisberger, F., Smieskova, R., Rapp, C., Ittig, S., Soguel Dit Piquard, F., Studerus, E., Klosterkötter, J., Ruhrmann, S., Paruch, J., Julkowski, D., Hilboll, D., Sham, P., Cherny, S., Chen, E., Campbell, D., Li, M., Romeo Casabona, C., Cirión, A., Mora, A., Jones, P., Kirkbride, J., Cannon, M., Rujescu, D., Tarricone, I., Berardi, D., Bonora, E., Seri, M., Marcacci, T., Chiri, L., Chierzi, F., Storbini, V., Braca, M., Minenna, M., Donegani, I., Fioritti, A., LA BARBERA, D., LA CASCIA, C., Mulè, A., Sideli, L., Sartorio, C., Ferraro, L., Tripoli, G., Seminerio, F., Marinaro, A., Mcgorry, P., Nelson, B., Amminger, G., Pantelis, C., Menezes, P., Del Ben, C., Tenan, S., Shuhama, R., Ruggeri, M., Tosato, S., Lasalvia, A., Bonetto, C., Ira, E., Nordentoft, M., Krebs, M., Barrantes Vidal, N., Cristóbal, P., Kwapil, T., Brietzke, E., Bressan, R., Gadelha, A., Maric, N., Andric, S., Mihaljevic, M., Mirjanic, T., Psychiatrie & Neuropsychologie, Promovendi MHN, and RS: MHeNs - R2 - Mental Health

Subjects
URBANICITY, Schizophrenia (object-oriented programming), CHILDHOOD, Genome-wide association study, VARIANTS, Social Environment, psychosi, 03 medical and health sciences, 0302 clinical medicine, PSYCHOSIS, epidemiology, gene-environment interaction, genetics, psychosis, schizophrenia, SDG 3 - Good Health and Well-being, RISK-FACTOR, Settore M-PSI/08 - Psicologia Clinica, Genetic variation, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, Gene, Settore MED/25 - Psichiatria, METAANALYSIS, Scale (chemistry), Psychosis, Genetic variants, Environment and Schizophrenia Invited, CANNABIS USE, 3. Good health, 030227 psychiatry, Psychiatry and Mental health, Evolutionary biology, Identification (biology), Schizophrenic Psychology, Population Risk, genetic, Psychology, FOLLOW-UP, 030217 neurology & neurosurgery, FUTURE-DIRECTIONS, Clinical psychology
Abstract

European Community Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci,South Limburg Mental H, NL-6200 MD Maastricht, Netherlands Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England Mondriaan Mental Hlth Trust, Maastricht, Heerlen, Netherlands Univ Groningen, Univ Med Ctr Groningen, Rob Giel Clin Res, Univ Ctr Psychiat, Groningen, Netherlands Kings Coll London, Inst Psychiat, Dept Hlth Serv & Populat Res, London WC2R 2LS, England Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England Cardiff Univ, MRC, Ctr Neuropsychiat Genet, Cardiff CF10 3AX, S Glam, Wales Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany Dokuz Eylul Univ, Sch Med, Dept Psychiat, Konak, Turkey Istanbul Univ, Istanbul Fac Med, Dept Psychiat, Psychot Disorders Res Unit, Istanbul, Turkey Ankara Univ, Sch Med, Dept Psychiat, Cebeci Hosp, TR-06100 Ankara, Turkey Ankara Univ, Brain Res Ctr, TR-06100 Ankara, Turkey Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Middle E Tech Univ, Dept Psychol, TR-06531 Ankara, Turkey Diskapi YB Res & Training Hosp, Ankara, Turkey Turkish Federat Schizophrenia Assoc, Ankara, Turkey Ataturk Training & Res Hosp, Psychiat Clin, Ankara, Turkey Manisa Mental Hlth Hosp, Manisa, Turkey Istanbul Univ, Expt Med Res Inst, Dept Adv Neurol Sci, Istanbul Fac Med, Istanbul, Turkey Univ Complutense, IiSGM CIBERSAM, Dept Child & Adolescent Psychiat, Hosp Gen Univ Gregorio Maranon,Sch Med, E-28040 Madrid, Spain Univ Barcelona, Dept Psychiat, Hosp Clin, IDIBAPS,Ctr Invest Biomed Red Salud Mental CIBERS, Barcelona, Spain Univ Valencia, Sch Med, Dept Psychiat, Ctr Invest Biomed Red Salud Mental CIBERSAM, Valencia, Spain Univ Oviedo, Sch Med, Dept Med,Psychiat Area, Ctr Invest Biomed Red Salud Mental CIBERSAM, Oviedo, Spain Univ Santiago de Compostela, Dept Mental Hlth & Drug Addit Assistance, Hlth Serv Galicia,Psychiat Genet Grp IDIS, Hosp Clin,Ctr Invest Biomedica Red Salud Mental C, Santiago de Compostela 15706, Spain Hosp Virgen de la Luz, Serv Psiquiat, Dept Psychiat, Cuenca, Spain Hosp Univ Infanta Leonor Hosp Virgen Torre, Villa de Vallecas Mental Hlth Ctr, Villa de Vallecas Mental Hlth Dept, Madrid, Spain Hosp Univ Infanta Leonor Hosp Virgen Torre, Puente de Vallecas Mental Hlth Dept, Ctr Salud Mental Puente Vallecas, Madrid, Spain Hosp Clin Univ, Fdn Publ Galega Med Xenomica, Santiago de Compostela, Spain Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon, Dept Psychiat, E-28040 Madrid, Spain Hosp Psiquiatr Conxo, Santiago de Compostela, Spain Univ Amsterdam, Acad Med Ctr, Early Psychosis Sect, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands Vrije Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands EMGO Inst Hlth & Care Res, Amsterdam, Netherlands Parnassia Psychiat Inst, Dept Psychosis Res, the Hague, Netherlands Rivierduinen Psychiat Inst, Leiden, Netherlands Grp Hosp Mondor, AP HP, Creteil, France Hop Henri Mondor, INSERM, U955, Equipe 15, F-94010 Creteil, France Univ Paris Est, Fac Med, Creteil, France Fdn Fondamental, Creteil, France CMP B CHU, F-63003 Clermont Ferrand 1, France Univ Auvergne, EA 7280, Clermont Ferrand, France EPS Maison Blanche, Paris, France UPC KU Leuven, Dept Neurosci, UPC, Kortenberg, Belgium UPC, Dept Neurosci, Res Grp Psychiat, Leuven, Belgium Katholieke Univ Leuven, Univ Hosp Gasthuisberg, Dept Human Genet, Leuven, Belgium Assoc Sci Res Multiple Births, Ghent, Belgium Univ Ghent, Dept Neurol, Ghent Univ Hosp, B-9000 Ghent, Belgium Univ Athens, Sch Med, Eginit Hosp, Athens 11528, Greece Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria Psychiat Univ Clin Basel, Ctr Gender Res & Early Detect, Basel, Switzerland Psychiat Univ Clin Basel, Diagnost & Crisis Intervent Ctr, Basel, Switzerland Univ Cologne, Dept Psychiat & Psychotherapy, D-50931 Cologne, Germany Univ Hong Kong, Li Ka Shing Fac Med, Ctr Genom Sci, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong, Li Ka Shing Fac Med, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China Univ Basque Country, Univ Deusto, Interuniv Chair Law & Human Genome Prov Govt Bisk, Bilbao, Bizkaia, Spain Univ Zaragoza, Zaragoza, Spain Univ Cambridge, Dept Psychiat, Cambridge, England UCL, Div Psychiat, London, England Royal Coll Surgeons Ireland, Beaumont Hosp, Educ & Res Ctr, Dept Psychiat, Dublin 9, Ireland Univ Munich, Dept Psychiat, Div Mol & Clin Neurobiol, Munich, Germany Univ Bologna, Alma Mater Studiorium, Psychiat Unit, Dept Med & Surg Sci, Bologna, Italy Univ Bologna, Alma Mater Studiorium, Genet Unit, Dept Med & Surg Sci, Bologna, Italy Local Hlth Trust, Dept Mental Hlth & Pathol Addict, Bologna, Italy Univ Palermo, Sect Psychiat, Dept Expt Biomed & Clin Neurosci, Palermo, Italy P Giaccone Gen Hosp, Unit Psychiat, Palermo, Italy Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia Univ Melbourne, Melbourne Neuropsychiat Ctr, Carlton, Vic, Australia Univ São Paulo, Fac Med, Dept Med Prevent, BR-01246903 São Paulo, Brazil Univ São Paulo, Nucleo Pesquina Saude Mental Populac, São Paulo, Brazil Univ São Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, BR-14049 Ribeirao Preto, Brazil Univ Verona, Sect Psychiat, Dept Publ Hlth & Community Med, I-37100 Verona, Italy Copenhagen Univ Hosp, Res Unit, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark Univ Paris 05, Fac Med, Serv Hosp Univ, Hop St Anne, Paris, France Univ Autonoma Barcelona, Dept Psicol Clin & Salut, E-08193 Barcelona, Spain St Pere Claver Fundacio Sanitaria, Dept Salut Mental, Barcelona, Spain Univ N Carolina, Dept Psychol, Greensboro, NC 27412 USA CIBERSAM, Spanish Mental Hlth Res Network, Barcelona, Spain Universidade Federal de São Paulo, Dept Psychiat, PRISMA Early Intervent Program, São Paulo, Brazil Univ Belgrade, Sch Med, Beograd, Serbia Universidade Federal de São Paulo, Dept Psychiat, PRISMA Early Intervent Program, São Paulo, Brazil European Community: HEALTH-F2-2009-241909 Web of Science

Published
2014
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48. Early and very early-onset schizophrenia compared with adult-onset schizophrenia: French FACE-SZ database.

Author

Coulon N, Godin O, Bulzacka E, Dubertret C, Mallet J, Fond G, Brunel L, Andrianarisoa M, Anderson G, Chereau I, Denizot H, Rey R, Dorey JM, Lançon C, Faget C, Roux P, Passerieux C, Dubreucq J, Leignier S, Capdevielle D, André M, Aouizerate B, Misdrahi D, Berna F, Vidailhet P, Leboyer M, and Schürhoff F

Subjects
Adult, Child, Databases, Factual statistics & numerical data, Female, France epidemiology, Humans, Male, Prognosis, Psychiatric Status Rating Scales, Schizophrenic Psychology, Age of Onset, Psychotic Disorders diagnosis, Psychotic Disorders epidemiology, Schizophrenia diagnosis, Schizophrenia epidemiology
Abstract

Objective: To compare the clinical symptomatology in patients with Early-Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551)., Method: In a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were assessed using standardized and extensive clinical and neuropsychological batteries: AOS with onset ≥ 18 years and EOS with onset < 18 years (including 22 VEOS < 13 years)., Results: The importance of better diagnosing EOS group, and in particularly VEOS, appeared in a longer DUP Duration of Untreated Psychosis (respectively, 2.6 years ± 4.1 and 8.1 years ± 5.7 vs. 1.0 years ± 2.5), more severe symptomatology (PANSS Positive And Negative Syndrome Scale scores), and lower educational level than the AOS group. In addition, the VEOS subgroup had a more frequent childhood history of learning disabilities and lower prevalence of right-handedness quotient than the AOS., Conclusion: The study demonstrates the existence of an increased gradient of clinical severity from AOS to VEOS. In order to improve the prognosis of the early forms of schizophrenia and to reduce the DUP, clinicians need to pay attention to the prodromal manifestations of the disease., (© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.)

Published
2020
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49. Validation and refinement of the clinical staging model in a French cohort of outpatient with schizophrenia (FACE-SZ).

Author

Godin O, Fond G, Bulzacka E, Schürhoff F, Boyer L, Myrtille A, Andrianarisoa M, Aouizerate B, Berna F, Capdevielle D, Chereau I, Dorey JM, Dubertret C, Dubreucq J, Faget C, Lancon C, Leignier S, Mallet J, Misdrahi D, Passerieux C, Rey R, Roux P, Vidailhet P, Costagliola D, Leboyer M, and Llorca PM

Subjects
Adult, Algorithms, Comorbidity, Female, France epidemiology, Humans, Machine Learning, Male, Medication Adherence psychology, Neuropsychological Tests, Outpatients psychology, Polypharmacy, Schizophrenic Psychology, Young Adult, Cognitive Dysfunction epidemiology, Depressive Disorder, Major epidemiology, Schizophrenia classification, Schizophrenia epidemiology
Abstract

Objective: Existing staging models have not been fully validated. Thus, after classifying patients with schizophrenia according to the staging model proposed by McGorry et al. (2010), we explored the validity of this staging model and its stability after one-year of follow-up., Method: Using unsupervised machine-learning algorithm, we classified 770 outpatients into 5 clinical stages, the highest being the most severe. Analyses of (co)variance were performed to compare each stage in regard to socio-demographics factors, clinical characteristics, co-morbidities, ongoing treatment and neuropsychological profiles., Results: The precision of clinical staging can be improved by sub-dividing intermediate stages (II and III). Clinical validators of class IV include the presence of concomitant major depressive episode (42.6% in stage IV versus 3.4% in stage IIa), more severe cognitive profile, lower adherence to medication and prescription of >3 psychotropic medications. Follow-up at one-year showed good stability of each stage., Conclusion: Clinical staging in schizophrenia could be improved by adding clinical elements such as mood symptoms and cognition to severity, relapses and global functioning. In terms of therapeutic strategies, attention needs to be paid on the factors associated with the more stages of schizophrenia such as treatment of comorbid depression, reduction of the number of concomitant psychotropic medications, improvement of treatment adherence, and prescription of cognitive remediation., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2019
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50. [The 10-year findings from the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ): Review and recommendations for clinical practice].

Author

Schürhoff F, Fond G, Berna F, Bulzacka E, Godin O, Boyer L, Misdrahi D, Andrianarisoa M, Brunel L, Coulon N, Aouizerate B, Capdevielle D, Chereau I, D'Amato T, Dubertret C, Dubreucq J, Faget C, Gabayet F, Mallet J, Rey R, Lancon C, Passerieux C, Schandrin A, Urbach M, Vidailhet P, Leboyer M, and Llorca PM

Subjects
Adult, Age of Onset, Antipsychotic Agents adverse effects, Antipsychotic Agents therapeutic use, Cognition Disorders complications, Cognition Disorders epidemiology, Depressive Disorder, Major complications, Depressive Disorder, Major epidemiology, Female, France, Humans, Male, Metabolic Syndrome complications, Metabolic Syndrome epidemiology, Patient Compliance, Quality of Life, Schizophrenia complications, Schizophrenia epidemiology, Schizophrenic Psychology, Smoking epidemiology, Psychiatry standards, Schizophrenia therapy
Abstract

Objectives: The present article is a synthesis of the first 10 years of follow-up of the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ) cohort., Methods: More than 700 community-dwelling stabilized subjects have been recruited and evaluated to date. The mean age was 32 years with 75 % males, the mean illness duration was 11 years, the mean age at illness onset was 21 years, the mean duration of untreated psychosis was 1.5 years and 55 % were current daily tobacco smokers., Results: The major findings of the FACE-SZ cohort may be summarized as follows: the metabolic syndrome is twice more frequent in schizophrenia as compared to the general population and is not correctly assessed and treated; cognitive disturbances have been found in benzodiazepine consumers and in patients with chronic low-grade peripheral inflammation; major depressive disorder (MDD) is a common current comorbid condition in about 20% of the subjects at the evaluation. MDD is associated with impaired quality of life and with increased nicotine dependency in SZ daily tobacco smokers. Improving depression and negative symptoms may be the most effective strategies to improve quality of life in schizophrenia; the duration of untreated psychosis is much longer in cannabis smokers and in subjects with an age at illness onset<19 years. Adherence to treatment is diminished in subjects who report a subjective negative feeling after treatment intake independent of objective side effects (extrapyramidal syndrome and weight gain). Akathisia has been found in 18% of the subjects and has been associated with antipsychotic polytherapy., Conclusions: In the light of these results, some recommendations for clinical care may be suggested. The early detection of schizophrenia should be specifically increased in adolescents and/or cannabis smokers. All patients should be administered a comprehensive neuropsychological evaluation at the beginning of the illness and after stabilization under treatment. Improving metabolic parameters and lifestyle (diet and physical activity) should be reinforced. The benefit/risk ratio of benzodiazepine and antipsychotic polytherapy should be regularly reevaluated and withdrawn as soon as possible. If MDD remains underdiagnosed and undertreated, improving depression may strongly improve the quality of life of SZ subjects. In the end, Cognitive Remediation Therapy and anti-inflammatory strategies should be more frequently included in therapeutic strategies., (Copyright © 2018. Published by Elsevier Masson SAS.)

Published
2019
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