Search

Your search keyword '"Bunin N"' showing total 281 results
Start Over Author "Bunin N"

Refine your results

more »

more »

more »

more »
281 results on '"Bunin N"'

1. Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency

Author

Dvorak, CC, Hassan, A, Slatter, MA, Hönig, M, Lankester, AC, Buckley, RH, Pulsipher, MA, Davis, JH, Güngör, T, Gabriel, M, Bleesing, JH, Bunin, N, Sedlacek, P, Connelly, JA, Crawford, DF, Notarangelo, LD, Pai, SY, Hassid, J, Veys, P, Gennery, AR, and Cowan, MJ

Subjects
Immunology, Allergy
Abstract

Background Patients with severe combined immunodeficiency disease who have matched sibling donors (MSDs) can proceed to hematopoietic cell transplantation (HCT) without conditioning chemotherapy. Objective We sought to determine whether the results of HCT without chemotherapy-based conditioning from matched unrelated donors (URDs), either from volunteer adults or umbilical cord blood, are comparable with those from MSDs.

Published
2014

13. Les races chevalines : avec une étude spéciale sur les chevaux russes /

Author

Simonov, L. N., Bunin, N. 1856-1912, Merder, Ivan Karlovich, 1832-1907, Samokysh, Mykola, 1860-1944, Imprimerie Lemercier et cie, Rougeron, Vignerot & Cie, Webster Family Library of Veterinary Medicine (archive.org), Simonov, L. N., Bunin, N. 1856-1912, Merder, Ivan Karlovich, 1832-1907, Samokysh, Mykola, 1860-1944, Imprimerie Lemercier et cie, and Rougeron, Vignerot & Cie

Subjects
Horse breeds, Horses, Russia
Published
1894

17. Outcomes and Challenges of Manufacturing Virus-Specific Cytotoxic T-lymphocytes Using IFN-gamma Cytokine Capture System

Author

Maryamchik, E., primary, Kadauke, S., additional, Flower, A., additional, Barrett, D., additional, Ayello, J., additional, Harrison, L., additional, Morris, E., additional, Struhahn, M., additional, O'Donnell, L., additional, Lee, D.A., additional, Abu-Arja, R., additional, Johnson, B., additional, Talano, J., additional, Cairo, M.S., additional, Bunin, N., additional, and Wang, Y., additional

Published
2020
Full Text
View/download PDF

19. Hematopoietic stem cell transplantation in patients with gain-of-function signal transducer and activator of transcription 1 mutations

Author

Leiding, JW, Okada, S, Hagin, D, Abinun, M, Shcherbina, A, Balashov, DN, Kim, VHD, Ovadia, A, Guthery, SL, Pulsipher, M, Lilic, D, Devlin, LA, Christie, S, Depner, M, Fuchs, S, van Royen-Kerkhof, A, Lindemans, C, Petrovic, A, Sullivan, KE, Bunin, N, Kilic, SS, Arpaci, F, de la Calle-Martin, O, Martinez-Martinez, L, Aldave, JC, Kobayashi, M, Ohkawa, T, Imai, K, Iguchi, A, Roifman, CM, Gennery, AR, Slatter, M, Ochs, HD, Morio, T, Torgerson, TR, Inborn Errors Working Party, European Soc Blood Marrow, and Primary Immune Deficiency

Subjects
surgical procedures, operative, hemophagocytic lymphohistiocytosis, gain of function, graft-versus-host disease, chronic mucocutaneous candidiasis, Hematopoietic stem cell transplantation, graft rejection, Janus kinase, signal transducer and activator of transcription
Abstract

Background: Gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 (STAT1) cause susceptibility to a range of infections, autoimmunity, immune dysregulation, and combined immunodeficiency. Disease manifestations can be mild or severe and life-threatening. Hematopoietic stem cell transplantation (HSCT) has been used in some patients with more severe symptoms to treat and cure the disorder. However, the outcome of HSCT for this disorder is not well established. Objective: We sought to aggregate the worldwide experience of HSCT in patients with GOF-STAT1 mutations and to assess outcomes, including donor engraftment, overall survival, graft-versus-host disease, and transplant-related complications. Methods: Data were collected from an international cohort of 15 patients with GOF-STAT1 mutations who had undergone HSCT-using a variety of conditioning regimens and donor sources. Retrospective data collection allowed the outcome of transplantation to be assessed. In vitro functional testing was performed to confirm that each of the identified STAT1 variants was in fact a GOF mutation. Results: Primary donor engraftment in this cohort of 15 patients with GOF-STAT1 mutations was 74%, and overall survival was only 40%. Secondary graft failure was common (50%), and posttransplantation event-free survival was poor (10% by 100 days). Asubset of patients had hemophagocytic lymphohistiocytosis before transplant, contributing to their poor outcomes. Conclusion: Our data indicate that HSCT for patients with GOF-STAT1 mutations is curative but has significant risk of secondary graft failure and death.

Published
2018

42. Outcome of unrelated donor bone marrow transplantation in 40 children with Hurler syndrome

Author

Peters, C, primary, Balthazor, M, additional, Shapiro, EG, additional, King, RJ, additional, Kollman, C, additional, Hegland, JD, additional, Henslee- Downey, J, additional, Trigg, ME, additional, Cowan, MJ, additional, Sanders, J, additional, Bunin, N, additional, Weinstein, H, additional, Lenarsky, C, additional, Falk, P, additional, Harris, R, additional, Bowen, T, additional, Williams, TE, additional, Grayson, GH, additional, Warkentin, P, additional, Sender, L, additional, Cool, VA, additional, Crittenden, M, additional, Packman, S, additional, Kaplan, P, additional, and Lockman, LA, additional

Published
1996
Full Text
View/download PDF

49. Fatal Pulmonary Microsporidiosis Due to Encephalitozoon cuniculi Following Allogeneic Bone Marrow Transplantation for Acute Myelogenous Leukemia.

Author

Orenstein, J. M., Russo, P., Didier, E. S., Bowers, C., Bunin, N., and Teachey, D. T.

Subjects
BONE marrow transplantation, ACUTE myeloid leukemia, NOSEMA cuniculi, HIV-positive persons, MICROSPORIDIOSIS, MYELOID leukemia
Abstract

Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of microsporidiosis have been reported during the past 20 years, in patients with HIV/AIDS, while only relatively rare cases have been described in immunocompetent individuals. However, microsporidia infections are being increasingly reported in patients following solid-organ transplanation, where the main symptom has been diarrhea. The authors report the first case of pulmonary microsporidial infection in an allogeneic bone marrow transplant recipient in the United States and only the second case in the world. The patient, with a history of Hodgkin disease followed by acute myelogenous leukemia received a T-cell-depleted graft, but succumbed to respiratory failure 63 days post transplantation. An open lung biopsy, taken just before death, was originally thought to show toxoplasmosis. The correct diagnosis of microsporidiosis was made postmortem by light and electron microscopy. DNA polymerase chain reaction analysis confirmed the diagnosis and furthermore revealed it to be the dog strain of the microsporidia species Encephalitozoon cuniculi . Although to date rarely diagnosed, microsporidial infection should also be considered in the differential diagnosis of, e.g., unexplained pulmonary infection in bone marrow transplant patients. [ABSTRACT FROM AUTHOR]

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results