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2. Reduced antibody activity against SARS-CoV-2 B.1.617.2 delta virus in serum of mRNA-vaccinated individuals receiving tumor necrosis factor-α inhibitors

Author

Chen, Rita E., Gorman, Matthew J., Zhu, Daniel Y., Carreño, Juan Manuel, Yuan, Dansu, VanBlargan, Laura A., Burdess, Samantha, Lauffenburger, Douglas A., Kim, Wooseob, Turner, Jackson S., Droit, Lindsay, Handley, Scott A., Chahin, Salim, Deepak, Parakkal, O’Halloran, Jane A., Paley, Michael A., Presti, Rachel M., Wu, Gregory F., Krammer, Florian, Alter, Galit, Ellebedy, Ali H., Kim, Alfred H.J., and Diamond, Michael S.

Published
2021
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3. Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB–CD8+ memory T cells and accumulation of type 2 memory T cells

Author

Terekhova, Marina, primary, Swain, Amanda, additional, Bohacova, Pavla, additional, Aladyeva, Ekaterina, additional, Arthur, Laura, additional, Laha, Anwesha, additional, Mogilenko, Denis A., additional, Burdess, Samantha, additional, Sukhov, Vladimir, additional, Kleverov, Denis, additional, Echalar, Barbora, additional, Tsurinov, Petr, additional, Chernyatchik, Roman, additional, Husarcikova, Kamila, additional, and Artyomov, Maxim N., additional

Published
2024
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6. Su1481: IMPACT OF IMMUNOSUPPRESSIVE THERAPIES ON ANTIBODY DECAY FOLLOWING MRNA VACCINATION TO SARS-COV-2 IN A PROSPECTIVE COHORT OF PATIENTS WITH CHRONIC INFLAMMATORY DISEASES

Author

Deepak, Parakkal, primary, Kim, Wooseob, additional, Paley, Michael, additional, Yang, Monica, additional, Burdess, Samantha, additional, Carvidi, Alexander B., additional, Demissie, Emanuel, additional, El-Qunni, Alia A., additional, Haile, Alem, additional, Huang, Katherine, additional, Escudero, Guadalupe Oliva, additional, McMorrow, Lily E., additional, Paez, Diana, additional, Pawar, Niti, additional, Perantie, Dana C., additional, Schriefer, Rebecca E., additional, Sides, Shannon E., additional, Thapa, Mahima, additional, Gergely, Maté, additional, Akuse, Sewuese E., additional, Klebert, Michael, additional, Mitchell, Lynne, additional, Nix, Billy D., additional, Graf, Jonathan, additional, Taylor, Kimberly E., additional, Chahin, Salim, additional, Ciorba, Matthew A., additional, Katz, Patricia, additional, Matloubian, Mehrdad, additional, O'Halloran, Jane A., additional, Presti, Rachel M., additional, Wu, Gregory F., additional, Gensler, Lianne S., additional, Nakamura, Mary C., additional, Ellebedy, Ali H., additional, and Kim, Alfred H., additional

Published
2022
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7. Reduced antibody activity against SARS-CoV-2 B.1.617.2 Delta virus in serum of mRNA-vaccinated patients receiving TNF-α inhibitors

Author

Chen, Rita E., primary, Gorman, Matthew J., additional, Zhu, Daniel Y., additional, Carreño, Juan Manuel, additional, Yuan, Dansu, additional, VanBlargan, Laura A., additional, Burdess, Samantha, additional, Lauffenburger, Douglas A., additional, Kim, Wooseob, additional, Turner, Jackson S., additional, Droit, Lindsay, additional, Handley, Scott A., additional, Chahin, Salim, additional, Deepak, Parakkal, additional, O’Halloran, Jane A., additional, Paley, Michael, additional, Presti, Rachel M., additional, Wu, Gregory F., additional, Krammer, Florian, additional, Alter, Galit, additional, Ellebedy, Ali H., additional, Kim, Alfred H. J., additional, and Diamond, Michael S., additional

Published
2021
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8. -Itaconate confers tolerance to late NLRP3 inflammasome activation

Author

Bambouskova, Monika, primary, Potuckova, Lucie, additional, Paulenda, Tomas, additional, Kerndl, Martina, additional, Mogilenko, Denis A., additional, Lizotte, Kate, additional, Swain, Amanda, additional, Hayes, Sebastian, additional, Sheldon, Ryan D., additional, Kim, Hyeryun, additional, Kapadnis, Unnati, additional, Ellis, Abigail E., additional, Isaguirre, Christine, additional, Burdess, Samantha, additional, Laha, Anwesha, additional, Amarasinghe, Gaya K., additional, Chubukov, Victor, additional, Roddy, Thomas P., additional, Diamond, Michael S., additional, Jones, Russell J., additional, Simons, Donald M., additional, and Artyomov, Maxim N., additional

Published
2021
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9. Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Author

Mogilenko, Denis A., primary, Shpynov, Oleg, additional, Andhey, Prabhakar Sairam, additional, Arthur, Laura, additional, Swain, Amanda, additional, Esaulova, Ekaterina, additional, Brioschi, Simone, additional, Shchukina, Irina, additional, Kerndl, Martina, additional, Bambouskova, Monika, additional, Yao, Zhangting, additional, Laha, Anwesha, additional, Zaitsev, Konstantin, additional, Burdess, Samantha, additional, Gillfilan, Susan, additional, Stewart, Sheila A., additional, Colonna, Marco, additional, and Artyomov, Maxim N., additional

Published
2021
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11. Itaconate confers tolerance to late NLRP3 inflammasome activation

Author

Bambouskova, Monika, Potuckova, Lucie, Paulenda, Tomas, Kerndl, Martina, Mogilenko, Denis A., Lizotte, Kate, Swain, Amanda, Hayes, Sebastian, Sheldon, Ryan D., Kim, Hyeryun, Kapadnis, Unnati, Ellis, Abigail E., Isaguirre, Christine, Burdess, Samantha, Laha, Anwesha, Amarasinghe, Gaya K., Chubukov, Victor, Roddy, Thomas P., Diamond, Michael S., Jones, Russell G., Simons, Donald M., and Artyomov, Maxim N.

Abstract

Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconate is a key regulator of the signal 2 of NLR family pyrin domain containing 3 (NLRP3) inflammasome activation after long lipopolysaccharide (LPS) priming, which establishes tolerance to late NLRP3 inflammasome activation. We show that itaconate acts synergistically with inducible nitric oxide synthase (iNOS) and that the ability of various TLR ligands to establish NLRP3 inflammasome tolerance depends on the pattern of co-expression of IRG1 and iNOS. Mechanistically, itaconate accumulation upon prolonged inflammatory stimulation prevents full caspase-1 activation and processing of gasdermin D, which we demonstrate to be post-translationally modified by endogenous itaconate. Altogether, our data demonstrate that metabolic rewiring in inflammatory macrophages establishes tolerance to NLRP3 inflammasome activation that, if uncontrolled, can result in pyroptotic cell death and tissue damage.

Published
2021
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13. Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK + CD8 + T Cells as Conserved Hallmark of Inflammaging.

Author

Mogilenko DA, Shpynov O, Andhey PS, Arthur L, Swain A, Esaulova E, Brioschi S, Shchukina I, Kerndl M, Bambouskova M, Yao Z, Laha A, Zaitsev K, Burdess S, Gillfilan S, Stewart SA, Colonna M, and Artyomov MN

Subjects
Animals, Cells, Cultured, Clone Cells, Cytotoxicity, Immunologic, Female, Gene Expression Profiling, Granzymes metabolism, Humans, Immunologic Memory, Mice, Mice, Inbred C57BL, Sequence Analysis, RNA, Single-Cell Analysis, Transcriptome, Aging physiology, CD8-Positive T-Lymphocytes physiology, Immune System physiology, Inflammation immunology, Receptors, Antigen, B-Cell genetics, Receptors, Antigen, T-Cell genetics
Abstract

Systematic understanding of immune aging on a whole-body scale is currently lacking. We characterized age-associated alterations in immune cells across multiple mouse organs using single-cell RNA and antigen receptor sequencing and flow cytometry-based validation. We defined organ-specific and common immune alterations and identified a subpopulation of age-associated granzyme K (GZMK)-expressing CD8 + T (Taa) cells that are distinct from T effector memory (Tem) cells. Taa cells were highly clonal, had specific epigenetic and transcriptional signatures, developed in response to an aged host environment, and expressed markers of exhaustion and tissue homing. Activated Taa cells were the primary source of GZMK, which enhanced inflammatory functions of non-immune cells. In humans, proportions of the circulating GZMK + CD8 + T cell population that shares transcriptional and epigenetic signatures with mouse Taa cells increased during healthy aging. These results identify GZMK + Taa cells as a potential target to address age-associated dysfunctions of the immune system., Competing Interests: Declaration of Interests The authors declare no competing interests., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2021
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