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10. Topiramate-chitosan nanoparticles prevent morphine reinstatement with no memory impairment: Dopaminergic and glutamatergic molecular aspects in rats

Author

Milanesi, Laura Hautrive, primary, Rossato, Domenika Rubert, additional, Oliveira da Rosa, Jéssica Leandra, additional, D'avila, Lívia Ferraz, additional, Metz, Vinicia Garzella, additional, Wolf, Jéssica Fernanda, additional, Reis, Vanessa B., additional, de Andrade, Diego F., additional, Jank, Louise, additional, Beck, Ruy C.R., additional, da Silva, Cristiane de B., additional, and Burger, Marilise E., additional

Published
2021
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11. The continued need for animals to advance brain research

Author

Homberg, Judith R., primary, Adan, Roger A.H., additional, Alenina, Natalia, additional, Asiminas, Antonis, additional, Bader, Michael, additional, Beckers, Tom, additional, Begg, Denovan P., additional, Blokland, Arjan, additional, Burger, Marilise E., additional, van Dijk, Gertjan, additional, Eisel, Ulrich L.M., additional, Elgersma, Ype, additional, Englitz, Bernhard, additional, Fernandez-Ruiz, Antonio, additional, Fitzsimons, Carlos P., additional, van Dam, Anne-Marie, additional, Gass, Peter, additional, Grandjean, Joanes, additional, Havekes, Robbert, additional, Henckens, Marloes J.A.G., additional, Herden, Christiane, additional, Hut, Roelof A., additional, Jarrett, Wendy, additional, Jeffrey, Kate, additional, Jezova, Daniela, additional, Kalsbeek, Andries, additional, Kamermans, Maarten, additional, Kas, Martien J., additional, Kasri, Nael Nadif, additional, Kiliaan, Amanda J., additional, Kolk, Sharon M., additional, Korosi, Aniko, additional, Korte, S. Mechiel, additional, Kozicz, Tamas, additional, Kushner, Steven A., additional, Leech, Kirk, additional, Lesch, Klaus-Peter, additional, Lesscher, Heidi, additional, Lucassen, Paul J., additional, Luthi, Anita, additional, Ma, Liya, additional, Mallien, Anne S., additional, Meerlo, Peter, additional, Mejias, Jorge F., additional, Meye, Frank J., additional, Mitchell, Anna S., additional, Mul, Joram D., additional, Olcese, Umberto, additional, González, Azahara Oliva, additional, Olivier, Jocelien D.A., additional, Pasqualetti, Massimo, additional, Pennartz, Cyriel M.A., additional, Popik, Piotr, additional, Prickaerts, Jos, additional, de la Prida, Liset M., additional, Ribeiro, Sidarta, additional, Roozendaal, Benno, additional, Rossato, Janine I., additional, Salari, Ali-Akbar, additional, Schoemaker, Regien G., additional, Smit, August B., additional, Vanderschuren, Louk J.M.J., additional, Takeuchi, Tomonori, additional, van der Veen, Rixt, additional, Smidt, Marten P., additional, Vyazovskiy, Vladyslav V., additional, Wiesmann, Maximilian, additional, Wierenga, Corette J., additional, Williams, Bella, additional, Willuhn, Ingo, additional, Wöhr, Markus, additional, Wolvekamp, Monique, additional, van der Zee, Eddy A., additional, and Genzel, Lisa, additional

Published
2021
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12. The continued need for animals to advance brain research

Author

Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Published
2021

13. The continued need for animals to advance brain research

Author

Homberg, Judith R, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Homberg, Judith R, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Abstract

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

14. The continued need for animals to advance brain research

Author

Homberg, Judith R., Adan, Roger A. H., Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P., Blokland, Arjan, Burger, Marilise E., van Dijk, Gertjan, Eisel, Ulrich L. M., Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P., van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J. A. G., Herden, Christiane, Hut, Roelof A., Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J., Kasri, Nael Nadif, Kiliaan, Amanda J., Kolk, Sharon M., Korosi, Aniko, Korte, S. Mechiel, Kozicz, Tamas, Kushner, Steven A., Leech, Kirk, Leech, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J., Luthi, Anita, Ma, Liya, Mallien, Anne S., Meerlo, Peter, Mejias, Jorge F., Meye, Frank J., Mitchell, Anna S., Mul, Joram D., Olcese, Umberto, Gonzalez, Azahara Oliva, Oliver, Jocelien D. A., Pasqualetti, Massimo, Pennartz, CyrielM. A., Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M., Ribeiro, Sidarta, Roozendaal, Benn, Rossato, Janine I., Salari, Ali-Akbar, Schoemaker, Regien G., Smit, August B., Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P., V. Vyazovskiy, Vladyslav, Wiesmann, Maximilian, Wierenga, Corette J., Williams, Bella, Willuhn, Ingo, Woehr, Markus, Wolvekamp, Monique, van der Zee, Eddy A., Genzel, Lisa, Vanderschuren, Louk J. M. J., Homberg, Judith R., Adan, Roger A. H., Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P., Blokland, Arjan, Burger, Marilise E., van Dijk, Gertjan, Eisel, Ulrich L. M., Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P., van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J. A. G., Herden, Christiane, Hut, Roelof A., Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J., Kasri, Nael Nadif, Kiliaan, Amanda J., Kolk, Sharon M., Korosi, Aniko, Korte, S. Mechiel, Kozicz, Tamas, Kushner, Steven A., Leech, Kirk, Leech, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J., Luthi, Anita, Ma, Liya, Mallien, Anne S., Meerlo, Peter, Mejias, Jorge F., Meye, Frank J., Mitchell, Anna S., Mul, Joram D., Olcese, Umberto, Gonzalez, Azahara Oliva, Oliver, Jocelien D. A., Pasqualetti, Massimo, Pennartz, CyrielM. A., Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M., Ribeiro, Sidarta, Roozendaal, Benn, Rossato, Janine I., Salari, Ali-Akbar, Schoemaker, Regien G., Smit, August B., Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P., V. Vyazovskiy, Vladyslav, Wiesmann, Maximilian, Wierenga, Corette J., Williams, Bella, Willuhn, Ingo, Woehr, Markus, Wolvekamp, Monique, van der Zee, Eddy A., Genzel, Lisa, and Vanderschuren, Louk J. M. J.

Abstract

C Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

15. The continued need for animals to advance brain research

Author

TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa

Published
2021

17. Uncaria tomentosa improves cognition, memory and learning in middle-aged rats

Author

Castilhos, Lívia G., primary, Oliveira, Juliana S., additional, Adefegha, Stephen A., additional, Manzoni, Alessandra G., additional, Passos, Daniela F., additional, Assmann, Charles E., additional, Silveira, Leonardo L., additional, Trelles, Kelly B., additional, Kronbauer, Maikel, additional, Doleski, Pedro H., additional, Bremm, João M., additional, Braun, Josiane, additional, Abdalla, Fatima H., additional, Gonçalves, Jamile F., additional, Andrade, Cinthia M., additional, Cruz, Ivana B.M., additional, Burger, Marilise E., additional, and Leal, Daniela B.R., additional

Published
2020
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28. Hydrogels Containing Nanocapsules and Nanoemulsions of Tea Tree Oil Provide Antiedematogenic Effect and Improved Skin Wound Healing

Author

Flores, Fernanda C., primary, de Lima, Julia A., additional, da Silva, Cássia R., additional, Benvegnú, Dalila, additional, Ferreira, Juliano, additional, Burger, Marilise E., additional, Beck, Ruy C. R., additional, Rolim, Clarice M. B., additional, Rocha, Maria Isabel U. M., additional, da Veiga, Marcelo L., additional, and da Silva, Cristiane De B., additional

Published
2015
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29. Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats.

Author

Antoniazzi, Caren T. D., Metz, Vinícia G., Roversi, Karine, Freitas, Daniele L., Vey, Luciana T., Dias, Verônica T., Segat, Hecson J., Duarte, Marta M. M. F., and Burger, Marilise E.

Abstract

ABSTRACT Recent studies have shown that tactile stimulation (TS) in pups is able to prevent and/or minimize fear, anxiety behaviors, and addiction to psychostimulant drugs in adult rats. In these studies, animals have been exposed to handling from postnatal day (PND) 1-21. This study was designed to precisely establish which period of preweaning development has a greater influence of TS on neuronal development. After birth, male pups were exposed to TS from PND1-7, PND8-14, and PND15-21. In adulthood, the different periods of postnatal TS were assessed through behavioral, biochemical, and molecular assessments. Animals that received TS from PND8-14 showed lower anxiety-like symptoms, as observed by decreased anxiety index in elevated plus maze. This same TS period was able to improve rats' working memory by increasing the percentage of alternation rate in Y-maze, and induce better ability to cope with stressful situations, as showed in the defensive burying test by a reduced time of burying behavior. On the other hand, animals receiving TS in the first week of life showed longest cumulative burying time, which is directly related to increased anxiety-like behavior. Moreover, TS from PND8-14 showed lower corticosterone levels and better oxidative status, as observed by decreased lipid peroxidation and increased catalase activity in the hippocampus. Brain-derived neurotrophic factor (BDNF) immunocontent was increased in the hippocampus of animals receiving TS from PND8-14, while glucocorticoid receptors immunocontent was decreased in both TS1-7 and TS15-21, but not TS8-14. To the best of our knowledge, this study is the first to show TS can be more efficient if applied over a focused period of neonatal development (PND8-14) and this beneficial influence can be reflected on reduced emotionality and increased ability to address stressful situations in adulthood. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Aqueous extract of pecan nut shell (Carya illinoensis [Wangenh.] K. Koch) exerts protection against oxidative damage induced by cyclophosphamide in rat testis.

Author

Benvegnu DM, Barcelos RC, Roversi K, Boufleur N, Pase CS, Trevizol F, Segat HJ, Dias VT, Dolci GS, Antoniazzi CT, Reckziegel P, Lima F, de Lima LA, de Carvalho LM, da Silva Junior VA, and Burger ME

Subjects
Animals, Ascorbic Acid metabolism, Catalase metabolism, Cyclophosphamide adverse effects, L-Lactate Dehydrogenase metabolism, Lipid Peroxidation drug effects, Male, Models, Animal, Nuts, Phytotherapy, Plant Extracts therapeutic use, Rats, Rats, Wistar, Superoxide Dismutase metabolism, Testis drug effects, Carya, Cyclophosphamide pharmacology, Oxidative Stress drug effects, Plant Extracts pharmacology, Testis metabolism, Testis pathology
Abstract

This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE) on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy.

Published
2013
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