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1. Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)—A prospective multicenter study

Author

Dähne, Theo, primary, Bauer, Wolfgang, additional, Essig, Andreas, additional, Schaaf, Bernhard, additional, Barten-Neiner, Grit, additional, Spinner, Christoph D., additional, Pletz, Mathias W., additional, Rohde, Gernot, additional, Rupp, Jan, additional, Witzenrath, Martin, additional, Panning, Marcus, additional, Fuchs, A., additional, Engelmannn, M., additional, Stolz, D., additional, Bauer, W., additional, Mücke, H.C., additional, Suttorp, N., additional, Witzenrath, M., additional, Schmager, S., additional, Schaaf, B., additional, Kremling, J., additional, Nickoleit-Bitzenberger, D., additional, Azzaui, H., additional, Hower, M., additional, Hempel, F., additional, Prebeg, K., additional, Popkirova, K., additional, Kolditz, M., additional, Rohde, G., additional, Bellinghausen, C., additional, Grünewaldt, A., additional, Panning, M., additional, Welte, T., additional, Fühner, T., additional, van't Klooster, M., additional, Barten-Neiner, G., additional, Kröner, W., additional, Unruh, Ol., additional, Adaskina, N., additional, Eberherdt, F., additional, Julius, C., additional, Illig, T., additional, Klopp, N., additional, Pletz, M., additional, Schleenvoigt, B.T., additional, Forstner, C., additional, Moeser, A., additional, Ankert, J., additional, Drömannn, D., additional, Parschke, P., additional, Franzen, K., additional, Rupp, J., additional, Käding, N., additional, Waldeck, F., additional, Spinner, C., additional, Erber, J., additional, Voit, F., additional, Schneider, J., additional, Heigener, D., additional, Hering, I., additional, Albrich, W., additional, Seneghini, M., additional, Rassouli, F., additional, Baldesberger, S., additional, Essig, A., additional, Stenger, S., additional, Wallner, M., additional, Burgmann, H., additional, Traby, L., additional, Schubert, L., additional, and Chen, R., additional

Published
2024
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2. Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)—A prospective multicenter study

Author

Fuchs, A., Engelmannn, M., Stolz, D., Bauer, W., Mücke, H.C., Suttorp, N., Witzenrath, M., Schmager, S., Schaaf, B., Kremling, J., Nickoleit-Bitzenberger, D., Azzaui, H., Hower, M., Hempel, F., Prebeg, K., Popkirova, K., Kolditz, M., Rohde, G., Bellinghausen, C., Grünewaldt, A., Panning, M., Welte, T., Fühner, T., van't Klooster, M., Barten-Neiner, G., Kröner, W., Unruh, Ol., Adaskina, N., Eberherdt, F., Julius, C., Illig, T., Klopp, N., Pletz, M., Schleenvoigt, B.T., Forstner, C., Moeser, A., Ankert, J., Drömannn, D., Parschke, P., Franzen, K., Rupp, J., Käding, N., Waldeck, F., Spinner, C., Erber, J., Voit, F., Schneider, J., Heigener, D., Hering, I., Albrich, W., Seneghini, M., Rassouli, F., Baldesberger, S., Essig, A., Stenger, S., Wallner, M., Burgmann, H., Traby, L., Schubert, L., Chen, R., Dähne, Theo, Bauer, Wolfgang, Essig, Andreas, Schaaf, Bernhard, Barten-Neiner, Grit, Spinner, Christoph D., Pletz, Mathias W., Rohde, Gernot, Rupp, Jan, Witzenrath, Martin, and Panning, Marcus

Published
2024
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4. AB1292 EFFECTS OF DMARD TREATMENT ON SARS-CoV-2 mRNA VACCINATION IN PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE: A MATCHED, PROSPECTIVE COHORT STUDY

Author

Simader, E., primary, Deimel, T., additional, Kartnig, F., additional, Tobudic, S., additional, Haslacher, H., additional, Karonitsch, T. M., additional, Mrak, D., additional, Nothnagl, T., additional, Perkmann, T., additional, Lechner-Radner, H., additional, Sautner, J., additional, Winkler, F., additional, Burgmann, H., additional, Aletaha, D., additional, Winkler, S., additional, Blüml, S., additional, and Mandl, P., additional

Published
2023
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5. Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study

Author

Pett, Sarah L, Kunisaki, Ken M, Wentworth, Deborah, Griffin, Timothy J, Kalomenidis, Ioannis, Nahra, Raquel, Montejano Sanchez, Rocio, Hodgson, Shane W, Ruxrungtham, Kiat, Dwyer, Dominic, Davey, Richard T, Wendt, Chris H, Lundgren, J, Jansson, P, Pearson, M, Aagaard, B, Hudson, F, Bennet, R, Pacciarini, F, Angus, B, Paton, N, Collaco Moraes, Y, Cooper, D, Pett, S, Emery, S, Courtney-Rogers, D, Robson, R, Gordin, F, Sanchez, A, Standridge, B, Vjecha, M, Moricz, A, Delfino, M, Belloso, W, Losso, M, Tillmann, K, Touloumi, G, Gioukari, V, Anagnostou, O, La Rosa, A, Saenz, M J, Lopez, P, Herrero, P, Portas, B, Avihingsanon, A, Ruxrungtham, K, Kaewon, P, Ubolyam, S, Brekke, K, Campbell, M, Denning, E, DuChene, A, Engen, N, George, M, Harrison, M, Neaton, J D, Nelson, R, Quan, S F, Schultz, T, Wentworth, D, Baxter, J, Brown, S, Hoover, M, Beigel, J, Davey, R T, Jr., Dewar, R, Gover, E, McConnell, R, Metcalf, J, Natarajan, V, Rehman, T, Voell, J, Dwyer, D E, Kok, J, Uyeki, T, Munroe, D, Paez, A, Bertrand, M, Temesgen, Z, Rizza, S, Wolfe, C, Carbonneau, J, Novak, R, Schwarber, M, Polenakovik, H, Clark, L, Patil, N, Riska, P, Omotosho, J, Faber, L, Markowitz, N, Glesby, M, Ham, K, Parenti, D, Simon, G, Baxter, J, Coburn, P, Freiberg, M, Koerbel, G, Dharan, N, Paez-Quinde, M, Gunter, J, Beilke, M, Lu, Z, Gunderson, E, Baker, J, Koletar, S, Harber, H, Hurt, C, Marcus, C, Allen, M, Cummins, S, Uslan, D, Bonam, T, Paez, A, Santiago, F, States, D, Gardner, E, DeHovitz, J, Holman, S, Watson, V, Nixon, D, Dwyer, D, Kabir, M, Pett, S, Kilkenny, F, Elliott, J, Garlick, J, McBride, J, Richmond, S, Barcan, L, Sanchez, M, Lopardo, G, Barcelona, L, Bonvehi, P, Temporiti, E R, Losso, M, Macias, L, Laplume, H, Daciuk, L, Warley, E, Tavella, S, Fernandez Cruz, E, Paño, J, Estrada, V, Lopetegui, P, Gimenez Julvez, T, Ryan, P, Sanz Moreno, J, Knobel, H, Soriano, V, Dalmau, D, Dockrell, D, Angus, B, Price, D, Newport, M, Chadwick, D, Østergaard, L, Yehdego, Y, Pedersen, C, Hergens, L, Joensen, Z, Aagaard, B, Kronborg, G, Collins, P, Nielsen, H, Gerstoft, J, Baadegaard, B, Koulouris, N, Antoniadou, A, Protopappas, K, Polixronopoulos, V, Diamantea, F, Sambatakou, H, Mariolis, I, Vassilopoulos, N, Gerogiannis, A, Pinedo Ramirez, Y, Cornelio Mauricio, E, Vega Bazalar, J, Castillo Cordova, R, Fãtkenhuerer, G, Thomas, E, Bergmann, F, Fõllmer, U, Rockstroh, J, Englehardt, A, Stephan, C, Thomas, E, Bogner, J, Brockmeyer, N, Klinker, H, Chetchotisakd, P, Jumpimai, T, Avihingsanon, A, Ruxrungtham, K, Clumeck, N, Kameya, K, Chu, M Y, Wu, T C, Horban, A, Bakowska, E, Burgmann, H, Tobudic, S, Maagaard, A, Wolff, M, and Allendes, G

Published
2018
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10. POS1243 ACCELERATED WANING OF PROTECTIVE IMMUNITY AFTER SARS-CoV-2 mRNA VACCINATION IN PATIENTS TREATED WITH BIOLOGICAL AND TARGETED SYNTHETIC DISEASE MODIFYING ANTIRHEUMATIC DRUGS

Author

Tobudic, S., primary, Simader, E., additional, Deimel, T., additional, Mandl, P., additional, Haslacher, H., additional, Perkmann, T., additional, Schneider, L., additional, Nothnagl, T., additional, Lechner-Radner, H., additional, Winkler, F., additional, Burgmann, H., additional, Stiasny, K., additional, Novacek, G., additional, Reinisch, W., additional, Aletaha, D., additional, Winkler, S., additional, and Blüml, S., additional

Published
2022
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11. AB1135 RESPONSE TO SARS-COV-2 VACCINATION IN SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE DEPENDS ON IMMUNOSUPPRESSIVE REGIMEN: A MATCHED, PROSPECTIVE COHORT STUDY

Author

Mandl, P., primary, Tobudic, S., additional, Haslacher, H., additional, Mrak, D., additional, Nothnagl, T., additional, Perkmann, T., additional, Radner, H., additional, Sautner, J., additional, Simader, E., additional, Winkler, F., additional, Burgmann, H., additional, Aletaha, D., additional, Winkler, S., additional, and Blüml, S., additional

Published
2022
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13. Every fifth published metagenome is not available to science

Author

Eckert, E, Di Cesare, A, Fontaneto, D, Berendonk, T, Burgmann, H, Cytryn, E, Fatta-Kassinos, D, Franzetti, A, Joakim Larsson, D, Manaia, C, Pruden, A, Singer, A, Udikovic-Kolic, N, Corno, G, Eckert E. M., Di Cesare A., Fontaneto D., Berendonk T. U., Burgmann H., Cytryn E., Fatta-Kassinos D., Franzetti A., Joakim Larsson D. G., Manaia C. M., Pruden A., Singer A. C., Udikovic-Kolic N., Corno G., Eckert, E, Di Cesare, A, Fontaneto, D, Berendonk, T, Burgmann, H, Cytryn, E, Fatta-Kassinos, D, Franzetti, A, Joakim Larsson, D, Manaia, C, Pruden, A, Singer, A, Udikovic-Kolic, N, Corno, G, Eckert E. M., Di Cesare A., Fontaneto D., Berendonk T. U., Burgmann H., Cytryn E., Fatta-Kassinos D., Franzetti A., Joakim Larsson D. G., Manaia C. M., Pruden A., Singer A. C., Udikovic-Kolic N., and Corno G.

Abstract

Have you ever sought to use metagenomic DNA sequences reported in scientific publications? Were you successful? Here, we reveal that metagenomes from no fewer than 20% of the papers found in our literature search, published between 2016 and 2019, were not deposited in a repository or were simply inaccessible. The proportion of inaccessible data within the literature has been increasing year-on-year. Noncompliance with Open Data is best predicted by the scientific discipline of the journal. The number of citations, journal type (e.g., Open Access or subscription journals), and publisher are not good predictors of data accessibility. However, many publications in high-impact factor journals do display a higher likelihood of accessible metagenomic data sets. Twenty-first century science demands compliance with the ethical standard of data sharing of metagenomes and DNA sequence data more broadly. Data accessibility must become one of the routine and mandatory components of manuscript submissions-a requirement that should be applicable across the increasing number of disciplines using metagenomics. Compliance must be ensured and reinforced by funders, publishers, editors, reviewers, and, ultimately, the authors.

Published
2020

16. Impfungen

Author

Burgmann, H., Breyer, S., Kummer, Friedrich, editor, Konietzko, Nikolaus, editor, and Medici, Tullio C., editor

Published
2000
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18. No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020

Author

Panning, Marcus, Wiener, Julius, Dreher, M., Cornelissen, Christian, Knüppel, W., Stolz, D., Suttorp, N., Bauer, W., Mikolajewska, A., Witzenrath, M., Pankow, W., Gläser, S., Rothe, Kathrin, Thiemig, D., Prediger, M., Schmager, S., Kolditz, M., Schulte-Hubbert, B., Langner, S., Rohde, G., Bellinghausen, C., Panning, M., Hoffmann, C., Schneider, Jochen, Welte, T., Freise, J., Barten, G., Kröner, W., Nawrocki, M., Naim, J., Illig, T., Klopp, N., Pletz, M., Kroegel, C., Pletz, Mathias W., Schleenvoigt, B., Forstner, C., Moeser, A., Drömann, D., Parschke, P., Franzen, K., Rupp, J., Käding, N., Wouters, M., Walraven, K., Rohde, Gernot, Braeken, D., Spinner, C., Zaruchas, A., Schaberg, D, Heigener, D., Hering, I., Albrich, W., Waldeck, F., Rassouli, F., Baldesberger, S., Rupp, Jan, Stenger, S., Wallner, M., Burgmann, H., Traby, L., Witzenrath, Martin, Spinner, Christoph D., and Members of the CAPNETZ study group

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Respiratory pathogens, Epidemiology, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Community-acquired pneumonia, Internal medicine, Correspondence, Pandemic, Medicine, 030212 general & internal medicine, skin and connective tissue diseases, Multiplex RT-PCR, SARS-CoV-2, business.industry, fungi, General Medicine, medicine.disease, respiratory tract diseases, Community acquired pneumonia, ddc, body regions, Pneumonia, Infectious Diseases, Cohort, Rhinovirus, business, Cohort study
Abstract

Purpose The first SARS-CoV-2 cases in Europe were reported in January 2020. Recently, concern arose on unrecognized infections before this date. For a better understanding of the pandemic, we retrospectively analyzed patient samples for SARS-CoV-2 from the prospective CAPNETZ study cohort. Methods We used nasopharyngeal swab samples from a cohort of well characterized patients with community acquired pneumonia of the CAPNETZ study group, recruited from different geographic regions across Germany, Austria, the Netherlands, and Switzerland between 02nd December 2019 and 28th April 2020. Multiplex real-time RT-PCR for a broad range of respiratory pathogens and SARS-CoV-2 real-time RT-PCR were performed on all samples. Results In our cohort, respiratory pathogens other than SARS-CoV-2 were detected in 21.5% (42/195) of patients with rhinovirus as the most frequently detected pathogen. The detection rate increased to 29.7% (58/195) when SARS-CoV-2 was included. No SARS-CoV-2 positive sample was detected before end of March 2020. Conclusions Respiratory viral pathogens accounted for a considerable number of positive results but no SARS-CoV-2 case was identified before the end of March 2020.

Published
2020

23. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Author

Venkatesan, S, Myles, PR, Bolton, KJ, Muthuri, SG, Al Khuwaitir, T, Anovadiya, AP, Azziz-Baumgartner, E, Bajjou, T, Bassetti, M, Beovic, B, Bertisch, B, Bonmarin, I, Booy, R, Borja-Aburto, VH, Burgmann, H, Cao, B, Carratala, J, Chinbayar, T, Cilloniz, C, Denholm, JT, Dominguez, SR, Duarte, PAD, Dubnov-Raz, G, Fanella, S, Gao, Z, Gerardin, P, Giannella, M, Gubbels, S, Herberg, J, Higuera Iglesias, AL, Hoeger, PH, Hu, XY, Islam, QT, Jimenez, MF, Keijzers, G, Khalili, H, Kusznierz, G, Kuzman, I, Langenegger, E, Lankarani, KB, Leo, Y-S, Libster, RP, Linko, R, Madanat, F, Maltezos, E, Mamun, A, Manabe, T, Metan, G, Mickiene, A, Mikic, D, Mohn, KG, Oliva, ME, Ozkan, M, Parekh, D, Paul, M, Rath, BA, Refaey, S, Rodriguez, AH, Sertogullarindan, B, Skret-Magierlo, J, Somer, A, Talarek, E, Tang, JW, To, K, Dat, T, Uyeki, TM, Vaudry, W, Vidmar, T, Zarogoulidis, P, Nguyen-Van-Tam, JS, Venkatesan, S, Myles, PR, Bolton, KJ, Muthuri, SG, Al Khuwaitir, T, Anovadiya, AP, Azziz-Baumgartner, E, Bajjou, T, Bassetti, M, Beovic, B, Bertisch, B, Bonmarin, I, Booy, R, Borja-Aburto, VH, Burgmann, H, Cao, B, Carratala, J, Chinbayar, T, Cilloniz, C, Denholm, JT, Dominguez, SR, Duarte, PAD, Dubnov-Raz, G, Fanella, S, Gao, Z, Gerardin, P, Giannella, M, Gubbels, S, Herberg, J, Higuera Iglesias, AL, Hoeger, PH, Hu, XY, Islam, QT, Jimenez, MF, Keijzers, G, Khalili, H, Kusznierz, G, Kuzman, I, Langenegger, E, Lankarani, KB, Leo, Y-S, Libster, RP, Linko, R, Madanat, F, Maltezos, E, Mamun, A, Manabe, T, Metan, G, Mickiene, A, Mikic, D, Mohn, KG, Oliva, ME, Ozkan, M, Parekh, D, Paul, M, Rath, BA, Refaey, S, Rodriguez, AH, Sertogullarindan, B, Skret-Magierlo, J, Somer, A, Talarek, E, Tang, JW, To, K, Dat, T, Uyeki, TM, Vaudry, W, Vidmar, T, Zarogoulidis, P, and Nguyen-Van-Tam, JS

Abstract

BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. RESULTS: We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78-.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. CONCLUSIONS: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment.

Published
2020

47. Research update for articles published in EJCI in 2015

Author

Al-Daghri, N.M. Batzel, J.J. Burgmann, H. Carbone, F. Charmandari, E. Chrousos, G.P. Distelmaier, K. Cvirn, G. Dullaart, R.P.F. Dumitrascu, D.L. Esteve-Pastor, M.A. Gervasini, G. Goliasch, G. Goswami, N. Gruppen, E.G. Hernández-Mijares, A. Kalantaridou, S.N. Krause, R. Latini, R. Makrigiannakis, A. Marín, F. Masson, S. Montecucco, F. Ndrepepa, G. Nicolaides, N.C. Novelli, D. Orasan, O.H. Qorbani, M. Ratzinger, F. Roessler, A. Sabico, S. Sciatti, E. Stefanaki, C. Stoner, L. Tabatabaei-Malazy, O. Tatar, E. Toz, H. Uslu, A. Victor, V.M. Vizzardi, E.

Published
2017

50. Afrikanischer Augenwurm als Erstmanifestation einer Loiasis

Author

Burgmann H, Graninger W, Stefan Winkler, Egger S, and E C Wiesinger

Subjects
biology, Nausea, business.industry, Meningism, General Medicine, biology.organism_classification, Microfilaria, Diethylcarbamazine, Serology, Methylprednisolone, Anesthesia, parasitic diseases, medicine, Eosinophilia, medicine.symptom, Loa loa, business, medicine.drug
Abstract

HISTORY AND CLINICAL FINDINGS A 23-year-old woman suddenly had the sensation of a foreign body in her right eye. On looking into the mirror she saw what looked like a moving worm-like structure in the lateral angle of the eye. The patient had visited Cameroon 2 years previously. TESTS On ophthalmological examination with a slit-lamp a transparent worm, 6-7 cm long, was seen. Laboratory tests showed an eosinophilia of 13%, C-reactive protein slightly raised to 1.25 mg/dl and IgG of 2100 mg/dl (IgE was normal at 33 U/ml). Giemsa staining of a whole-blood drop contained numerous microfilaria typical of Loa loa (2000/ml). Filaria serology with antigen of Dipetalonema vitae (Acanthocheilonema) gave a positive response. TREATMENT AND COURSE The worm was removed surgically and, after a test dose, diethylcarbamazine, 6 mg/kg daily), was administered. Although methylprednisolone (initially 20 mg daily) was given concurrently, a fever of 38,5 degrees C developed on the 4th day. At the same time, streaky cutaneous eruptions were noted over the left lower arm and left knee bond. These two signs, which were due to two adult worms, disappeared within 2 days. On the 5th day the patient complained of headache, nausea and sensitivity to light, and she had meningism. The symptoms were treated with paracetamol and diazepam and quickly improved. The patient was discharged after 3 weeks. Further treatment cycles with diethylcarbamazine are planned.

Published
2008

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