Search

Your search keyword '"Burkart, Kristin M."' showing total 250 results
Start Over Author "Burkart, Kristin M."
250 results on '"Burkart, Kristin M."'

4. Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids

Author

Sinha, Pratik, Furfaro, David, Cummings, Matthew J, Abrams, Darryl, Delucchi, Kevin, Maddali, Manoj V, He, June, Thompson, Alison, Murn, Michael, Fountain, John, Rosen, Amanda, Robbins-Juarez, Shelief Y, Adan, Matthew A, Satish, Tejus, Madhavan, Mahesh, Gupta, Aakriti, Lyashchenko, Alexander K, Agerstrand, Cara, Yip, Natalie H, Burkart, Kristin M, Beitler, Jeremy R, Baldwin, Matthew R, Calfee, Carolyn S, Brodie, Daniel, and O’Donnell, Max R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Infectious Diseases, Acute Respiratory Distress Syndrome, Emerging Infectious Diseases, Rare Diseases, Good Health and Well Being, Adrenal Cortex Hormones, Aged, COVID-19, Cohort Studies, Female, Humans, Latent Class Analysis, Male, Middle Aged, Respiratory Distress Syndrome, Retrospective Studies, COVID-19 Drug Treatment, ARDS, latent class analysis, phenotyping, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Rationale: Two distinct subphenotypes have been identified in acute respiratory distress syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus disease (COVID-19) is unknown. Objectives: To identify clinically relevant, novel subgroups in COVID-19-related ARDS and compare them with previously described ARDS subphenotypes. Methods: Eligible participants were adults with COVID-19 and ARDS at Columbia University Irving Medical Center. Latent class analysis was used to identify subgroups with baseline clinical, respiratory, and laboratory data serving as partitioning variables. A previously developed machine learning model was used to classify patients as the hypoinflammatory and hyperinflammatory subphenotypes. Baseline characteristics and clinical outcomes were compared between subgroups. Heterogeneity of treatment effect for corticosteroid use in subgroups was tested. Measurements and Main Results: From March 2, 2020, to April 30, 2020, 483 patients with COVID-19-related ARDS met study criteria. A two-class latent class analysis model best fit the population (P = 0.0075). Class 2 (23%) had higher proinflammatory markers, troponin, creatinine, and lactate, lower bicarbonate, and lower blood pressure than class 1 (77%). Ninety-day mortality was higher in class 2 versus class 1 (75% vs. 48%; P

Published
2021

5. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.

Author

Zhao, Xutong, Qiao, Dandi, Yang, Chaojie, Kasela, Silva, Kim, Wonji, Ma, Yanlin, Shrine, Nick, Batini, Chiara, Sofer, Tamar, Taliun, Sarah A Gagliano, Sakornsakolpat, Phuwanat, Balte, Pallavi P, Prokopenko, Dmitry, Yu, Bing, Lange, Leslie A, Dupuis, Josée, Cade, Brian E, Lee, Jiwon, Gharib, Sina A, Daya, Michelle, Laurie, Cecelia A, Ruczinski, Ingo, Cupples, L Adrienne, Loehr, Laura R, Bartz, Traci M, Morrison, Alanna C, Psaty, Bruce M, Vasan, Ramachandran S, Wilson, James G, Taylor, Kent D, Durda, Peter, Johnson, W Craig, Cornell, Elaine, Guo, Xiuqing, Liu, Yongmei, Tracy, Russell P, Ardlie, Kristin G, Aguet, François, VanDenBerg, David J, Papanicolaou, George J, Rotter, Jerome I, Barnes, Kathleen C, Jain, Deepti, Nickerson, Deborah A, Muzny, Donna M, Metcalf, Ginger A, Doddapaneni, Harshavardhan, Dugan-Perez, Shannon, Gupta, Namrata, Gabriel, Stacey, Rich, Stephen S, O'Connor, George T, Redline, Susan, Reed, Robert M, Laurie, Cathy C, Daviglus, Martha L, Preudhomme, Liana K, Burkart, Kristin M, Kaplan, Robert C, Wain, Louise V, Tobin, Martin D, London, Stephanie J, Lappalainen, Tuuli, Oelsner, Elizabeth C, Abecasis, Goncalo R, Silverman, Edwin K, Barr, R Graham, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lung Working Group, Cho, Michael H, and Manichaikul, Ani

Subjects
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lung Working Group, Lung, Humans, Pulmonary Disease, Chronic Obstructive, Genetic Predisposition to Disease, Intracellular Signaling Peptides and Proteins, Calcium-Binding Proteins, Small Ubiquitin-Related Modifier Proteins, Follow-Up Studies, Feasibility Studies, Polymorphism, Single Nucleotide, Adult, Aged, Aged, 80 and over, Middle Aged, African Americans, Female, Male, Protein Inhibitors of Activated STAT, Respiratory Physiological Phenomena, Genome-Wide Association Study, Genetic Loci, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Whole Genome Sequencing, and over, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive
Abstract

Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497 participants from population- and family-based studies, and 8499 individuals from COPD-enriched studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. We identify at genome-wide significance 10 known GWAS loci and 22 distinct, previously unreported loci, including two common variant signals from stratified analysis of African Americans. Four novel common variants within the regions of PIAS1, RGN (two variants) and FTO show evidence of replication in the UK Biobank (European ancestry n ~ 320,000), while colocalization analyses leveraging multi-omic data from GTEx and TOPMed identify potential molecular mechanisms underlying four of the 22 novel loci. Our study demonstrates the value of performing WGS analyses and multi-omic follow-up in cohorts of diverse ancestry.

Published
2020

6. Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study

Author

Oelsner, Elizabeth C, Balte, Pallavi P, Grams, Morgan E, Cassano, Patricia A, Jacobs, David R, Barr, R Graham, Burkart, Kristin M, Kalhan, Ravi, Kronmal, Richard, Loehr, Laura R, O'Connor, George T, Schwartz, Joseph E, Shlipak, Michael, Tracy, Russell P, Tsai, Michael Y, White, Wendy, and Yende, Sachin

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Lung, Chronic Obstructive Pulmonary Disease, Prevention, Asthma, Clinical Research, Cardiovascular, Respiratory, Good Health and Well Being, Aged, Albuminuria, Cohort Studies, Comorbidity, Female, Humans, Incidence, Male, Middle Aged, National Heart, Lung, and Blood Institute (U.S.), Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests, Risk Factors, United States, epidemiology, spirometry, asthma, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleChronic lower respiratory diseases (CLRDs), including chronic obstructive pulmonary disease (COPD) and asthma, are the fourth leading cause of death. Prior studies suggest that albuminuria, a biomarker of endothelial injury, is increased in patients with COPD.ObjectivesTo test whether albuminuria was associated with lung function decline and incident CLRDs.MethodsSix U.S. population-based cohorts were harmonized and pooled. Participants with prevalent clinical lung disease were excluded. Albuminuria (urine albumin-to-creatinine ratio) was measured in spot samples. Lung function was assessed by spirometry. Incident CLRD-related hospitalizations and deaths were classified via adjudication and/or administrative criteria. Mixed and proportional hazards models were used to test individual-level associations adjusted for age, height, weight, sex, race/ethnicity, education, birth year, cohort, smoking status, pack-years of smoking, renal function, hypertension, diabetes, and medications.Measurements and main resultsAmong 10,961 participants with preserved lung function, mean age at albuminuria measurement was 60 years, 51% were never-smokers, median albuminuria was 5.6 mg/g, and mean FEV1 decline was 31.5 ml/yr. For each SD increase in log-transformed albuminuria, there was 2.81% greater FEV1 decline (95% confidence interval [CI], 0.86-4.76%; P = 0.0047), 11.02% greater FEV1/FVC decline (95% CI, 4.43-17.62%; P = 0.0011), and 15% increased hazard of incident spirometry-defined moderate-to-severe COPD (95% CI, 2-31%, P = 0.0021). Each SD log-transformed albuminuria increased hazards of incident COPD-related hospitalization/mortality by 26% (95% CI, 18-34%, P

Published
2019

7. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Author

Wyss, Annah B, Sofer, Tamar, Lee, Mi Kyeong, Terzikhan, Natalie, Nguyen, Jennifer N, Lahousse, Lies, Latourelle, Jeanne C, Smith, Albert Vernon, Bartz, Traci M, Feitosa, Mary F, Gao, Wei, Ahluwalia, Tarunveer S, Tang, Wenbo, Oldmeadow, Christopher, Duan, Qing, de Jong, Kim, Wojczynski, Mary K, Wang, Xin-Qun, Noordam, Raymond, Hartwig, Fernando Pires, Jackson, Victoria E, Wang, Tianyuan, Obeidat, Ma'en, Hobbs, Brian D, Huan, Tianxiao, Gui, Hongsheng, Parker, Margaret M, Hu, Donglei, Mogil, Lauren S, Kichaev, Gleb, Jin, Jianping, Graff, Mariaelisa, Harris, Tamara B, Kalhan, Ravi, Heckbert, Susan R, Paternoster, Lavinia, Burkart, Kristin M, Liu, Yongmei, Holliday, Elizabeth G, Wilson, James G, Vonk, Judith M, Sanders, Jason L, Barr, R Graham, de Mutsert, Renée, Menezes, Ana Maria Baptista, Adams, Hieab HH, van den Berge, Maarten, Joehanes, Roby, Levin, Albert M, Liberto, Jennifer, Launer, Lenore J, Morrison, Alanna C, Sitlani, Colleen M, Celedón, Juan C, Kritchevsky, Stephen B, Scott, Rodney J, Christensen, Kaare, Rotter, Jerome I, Bonten, Tobias N, Wehrmeister, Fernando César, Bossé, Yohan, Xiao, Shujie, Oh, Sam, Franceschini, Nora, Brody, Jennifer A, Kaplan, Robert C, Lohman, Kurt, McEvoy, Mark, Province, Michael A, Rosendaal, Frits R, Taylor, Kent D, Nickle, David C, Williams, L Keoki, Burchard, Esteban G, Wheeler, Heather E, Sin, Don D, Gudnason, Vilmundur, North, Kari E, Fornage, Myriam, Psaty, Bruce M, Myers, Richard H, O'Connor, George, Hansen, Torben, Laurie, Cathy C, Cassano, Patricia A, Sung, Joohon, Kim, Woo Jin, Attia, John R, Lange, Leslie, Boezen, H Marike, Thyagarajan, Bharat, Rich, Stephen S, Mook-Kanamori, Dennis O, Horta, Bernardo Lessa, Uitterlinden, André G, Im, Hae Kyung, Cho, Michael H, Brusselle, Guy G, and Gharib, Sina A

Subjects
Lung, Humans, Lung Diseases, Pulmonary Disease, Chronic Obstructive, Genetic Predisposition to Disease, Vital Capacity, Forced Expiratory Volume, Regression Analysis, Sample Size, Smoking, Genomics, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Quantitative Trait Loci, African Continental Ancestry Group, Asian Americans, European Continental Ancestry Group, Hispanic Americans, Female, Male, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive
Abstract

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.

Published
2018

8. Teaching Fellows

Author

Cooper, Avraham Z., Burkart, Kristin M., McCallister, Jennifer W., Rounds, Sharon I.S., Series Editor, Dixon, Anne, Series Editor, Schnapp, Lynn M., Series Editor, Kritek, Patricia A., editor, and Richards, Jeremy B., editor

Published
2019
Full Text
View/download PDF

9. A Genome-Wide Association Study of Chronic Obstructive Pulmonary Disease in Hispanics

Author

Chen, Wei, Brehm, John M, Manichaikul, Ani, Cho, Michael H, Boutaoui, Nadia, Yan, Qi, Burkart, Kristin M, Enright, Paul L, Rotter, Jerome I, Petersen, Hans, Leng, Shuguang, Obeidat, Ma’en, Bossé, Yohan, Brandsma, Corry-Anke, Hao, Ke, Rich, Stephen S, Powell, Rhea, Avila, Lydiana, Soto-Quiros, Manuel, Silverman, Edwin K, Tesfaigzi, Yohannes, Barr, R Graham, and Celedón, Juan C

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Human Genome, Lung, Atherosclerosis, Prevention, Genetics, Clinical Research, Chronic Obstructive Pulmonary Disease, Aetiology, 2.1 Biological and endogenous factors, Respiratory, Adolescent, Adult, Aged, Child, Female, Forced Expiratory Volume, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Hispanic or Latino, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Retrospective Studies, United States, Young Adult, COPD, genome-wide association studies, Hispanics, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleGenome-wide association studies (GWAS) of chronic obstructive pulmonary disease (COPD) have identified disease-susceptibility loci, mostly in subjects of European descent.ObjectivesWe hypothesized that by studying Hispanic populations we would be able to identify unique loci that contribute to COPD pathogenesis in Hispanics but remain undetected in GWAS of non-Hispanic populations.MethodsWe conducted a metaanalysis of two GWAS of COPD in independent cohorts of Hispanics in Costa Rica and the United States (Multi-Ethnic Study of Atherosclerosis [MESA]). We performed a replication study of the top single-nucleotide polymorphisms in an independent Hispanic cohort in New Mexico (the Lovelace Smokers Cohort). We also attempted to replicate prior findings from genome-wide studies in non-Hispanic populations in Hispanic cohorts.Measurements and main resultsWe found no genome-wide significant association with COPD in our metaanalysis of Costa Rica and MESA. After combining the top results from this metaanalysis with those from our replication study in the Lovelace Smokers Cohort, we identified two single-nucleotide polymorphisms approaching genome-wide significance for an association with COPD. The first (rs858249, combined P value = 6.1 × 10(-8)) is near the genes KLHL7 and NUPL2 on chromosome 7. The second (rs286499, combined P value = 8.4 × 10(-8)) is located in an intron of DLG2. The two most significant single-nucleotide polymorphisms in FAM13A from a previous genome-wide study in non-Hispanics were associated with COPD in Hispanics.ConclusionsWe have identified two novel loci (in or near the genes KLHL7/NUPL2 and DLG2) that may play a role in COPD pathogenesis in Hispanic populations.

Published
2015

12. Teaching Fellows

Author

Cooper, Avraham Z., primary, Burkart, Kristin M., additional, and McCallister, Jennifer W., additional

Published
2019
Full Text
View/download PDF

14. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmüller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Couto Alves, Alexessander, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliövaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kähönen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimäki, Terho, Letort, Sébastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melén, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O’Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Göran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlünssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valérie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, André G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widén, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.

Published
2018
Full Text
View/download PDF

20. Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring

Author

Gilmore, Emily J., Gaspard, Nicolas, Choi, Huimahn A., Cohen, Emily, Burkart, Kristin M., Chong, David H., and Claassen, Jan

Subjects
Brain -- Analysis -- Health aspects, Seizures (Medicine) -- Risk factors, Medical research -- Analysis -- Health aspects, Medicine, Experimental -- Analysis -- Health aspects, Mortality -- Analysis, Shock -- Risk factors, Infection -- Risk factors, Epilepsy -- Risk factors, Health care industry
Abstract

Purpose Investigate the prevalence, risk factors and impact of continuous EEG (cEEG) abnormalities on mortality through the 1-year follow-up period in patients with severe sepsis. Methods Prospective, single-center, observational study of consecutive patients admitted with severe sepsis to the Medical ICU at an academic medical center. Results A total of 98 patients with 100 episodes of severe sepsis were included; 49 patients (50%) were female, median age was 60 (IQR 52-74), the median non-neuro APACHE II score was 23.5 (IQR 18-28) and median non-neuro SOFA score was 8 (IQR 6-11). Twenty-five episodes had periodic discharges (PD), of which 11 had nonconvulsive seizures (NCS). No patient had NCS without PD. Prior neurological history was associated with a higher risk of PD or NCS (45 vs. 17%; CI 1.53-10.43), while the non-neuro APACHE II, non-neuro SOFA, severity of cardiovascular shock and presence of sedation during cEEG were associated with a lower risk of PD or NCS. Clinical seizures before cEEG were associated with a higher risk of nonconvulsive status epilepticus (24 vs. 6%; CI 1.42-19.94) while the non-neuro APACHE II and non-neuro SOFA scores were associated with a lower risk. Lack of EEG reactivity was present in 28% of episodes. In the survival analysis, a lack of EEG reactivity was associated with higher 1-year mortality [mean survival time 3.3 (95% CI 1.8-4.9) vs. 7.5 (6.4-8.7) months; p = 0.002] but the presence of PD or NCS was not [mean survival time 3.3 (95% CI 1.8-4.9) vs. 7.5 (6.4-8.7) months; p = 0.592]. Lack of reactivity was more frequent in patients on continuous sedation during cEEG. In patients with available 1-year data (34% of the episodes), 82% had good functional outcome (mRS [less than or equal to] 3, n = 27). There were no significant predictors of functional outcome, late cognition, and no patient with complete follow-up data developed late seizure or new epilepsy. Conclusions NCS and PD are common in patients with severe sepsis and altered mental status. They were less frequent among the most severely sick patients and were not associated with outcome in this study. Lack of EEG reactivity was more frequent in patients on continuous sedation and was associated with mortality up to 1 year after discharge. Larger studies are needed to confirm these findings in a broader population and to further evaluate long-term cognitive outcome, risk of late seizure and epilepsy., Author(s): Emily J. Gilmore [sup.1], Nicolas Gaspard [sup.2] [sup.3], Huimahn A. Choi [sup.4], Emily Cohen [sup.5], Kristin M. Burkart [sup.6], David H. Chong [sup.6], Jan Claassen [sup.7], Lawrence J. Hirsch [...]

Published
2015
Full Text
View/download PDF

21. The Virtual Interview Experience: Perspectives of Pulmonary and Critical Care Fellowship Applicants

Author

Allam, J. Shirine, primary, Burkart, Kristin M., additional, Çoruh, Başak, additional, Lee, May, additional, Hinkle, Laura, additional, Kreider, Maryl, additional, Tatem, Geneva, additional, Witt, Chad, additional, Ashton, Rendell W., additional, Huie, Tristan, additional, Moulton, Bart, additional, Awerbuch, Elizabeth, additional, and Bosslet, Gabriel T., additional

Published
2022
Full Text
View/download PDF

22. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author

Loth, Daan W, Artigas, María Soler, Gharib, Sina A, Wain, Louise V, Franceschini, Nora, Koch, Beate, Pottinger, Tess D, Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P, James, Alan L, Huffman, Jennifer E, Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J, Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Kähönen, Mika, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M, de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K, Fall, Tove, Viñuela, Ana, Launer, Lenore J, Loehr, Laura R, Fornage, Myriam, Li, Guo, Wilk, Jemma B, Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B, North, Kari E, Rudnicka, Alicja R, Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F, Hastie, Nicholas D, Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A, Pietiläinen, Kirsi H, Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G, Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M, Wojczynski, Mary, Pouta, Anneli, Johansson, Åsa, Wild, Sarah H, Ingelsson, Erik, Rivadeneira, Fernando, Völzke, Henry, Hysi, Pirro G, Eiriksdottir, Gudny, Morrison, Alanna C, Rotter, Jerome I, Gao, Wei, Postma, Dirkje S, White, Wendy B, Rich, Stephen S, Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J, Psaty, Bruce M, Lohman, Kurt, Burchard, Esteban G, Uitterlinden, André G, Garcia, Melissa, Joubert, Bonnie R, McArdle, Wendy L, Musk, A Bill, Hansel, Nadia, Heckbert, Susan R, Zgaga, Lina, van Meurs, Joyce B J, Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L, Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T, Ripatti, Samuli, Scott, Rodney J, Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C, Starr, John M, Wijmenga, Cisca, Minster, Ryan L, Lederer, David J, Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P, Gläser, Sven, Hammond, Christopher J, Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B, Gudnason, Vilmundur, Hancock, Dana B, Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F, Wjst, Matthias, Kim, Woo Jin, Porteous, David J, Scotland, Generation, Smith, Blair H, Viljanen, Anne, Heliövaara, Markku, Attia, John R, Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H, Teumer, Alexander, Spector, Timothy D, Melén, Erik, Peters, Marjolein J, Lange, Leslie A, Barr, R Graham, Bracke, Ken R, Verhamme, Fien M, Sung, Joohon, Hiemstra, Pieter S, Cassano, Patricia A, Sood, Akshay, Hayward, Caroline, Dupuis, Josée, Hall, Ian P, Brusselle, Guy G, Tobin, Martin D, and London, Stephanie J

Published
2014
Full Text
View/download PDF

25. Replication and fine mapping of asthma-associated loci in individuals of African ancestry

Author

Kantor, David B., Palmer, Cameron D., Young, Taylor R., Meng, Yan, Gajdos, Zofia K., Lyon, Helen, Price, Alkes L., Pollack, Samuela, London, Stephanie J., Loehr, Laura R., Smith, Lewis J., Kumar, Rajesh, Jacobs Jr., David R., Petrini, Marcy F., O’Connor, George T., White, Wendy B., Papanicolaou, George, Burkart, Kristin M., Heckbert, Susan R., Barr, R. Graham, and Hirschhorn, Joel N.

Published
2013
Full Text
View/download PDF

26. Supervised Machine Learning Approach to Identify Early Predictors of Poor Outcome in Patients with COVID-19 Presenting to a Large Quaternary Care Hospital in New York City

Author

Zucker, Jason, primary, Gomez-Simmonds, Angela, additional, Purpura, Lawrence J., additional, Shoucri, Sherif, additional, LaSota, Elijah, additional, Morley, Nicholas E., additional, Sovic, Brit W., additional, Castellon, Marvin A., additional, Theodore, Deborah A., additional, Bartram, Logan L., additional, Miko, Benjamin A., additional, Scherer, Matthew L., additional, Meyers, Kathrine A., additional, Turner, William C., additional, Kelly, Maureen, additional, Pavlicova, Martina, additional, Basaraba, Cale N., additional, Baldwin, Matthew R., additional, Brodie, Daniel, additional, Burkart, Kristin M., additional, Bathon, Joan, additional, Uhlemann, Anne-Catrin, additional, Yin, Michael T., additional, Castor, Delivette, additional, and Sobieszczyk, Magdalena E., additional

Published
2021
Full Text
View/download PDF

29. Development of a National Academic Boot Camp to Improve Fellowship Readiness

Author

Drake, Matthew G., primary, Shah, Nirav G., additional, Lee, May, additional, Brady, Anna, additional, Connors, Geoffrey R., additional, Clark, Brendan J., additional, Kritek, Patricia A., additional, McCallister, Jennifer W., additional, Burkart, Kristin M., additional, Pedraza, Isabel, additional, Jamieson, Daniel, additional, Ingram, Jennifer L., additional, Lynch, Lauren, additional, Makani, Samir S., additional, Siegel-Gasiewski, Jennifer, additional, Larsson, Eileen M., additional, Zemanick, Edith T., additional, Liptzin, Deborah R., additional, Good, Ryan, additional, and Crotty Alexander, Laura E., additional

Published
2021
Full Text
View/download PDF

30. Balancing Demands: Determinants of Burnout Reported by Fellows in Pulmonary and Critical Care Medicine

Author

O’Toole, Jacqueline, primary, Zaeh, Sandra, additional, Eakin, Michelle N., additional, Adelman, Mark H., additional, Ashton, Rendell W., additional, Biddison, Lee Daugherty, additional, Bosslet, Gabriel T., additional, Burkart, Kristin M., additional, Doyle, Stephen T., additional, Khan, Malik M. Khurram S., additional, Lenz, Peter H., additional, McCallister, Jennifer W., additional, Rand, Cynthia S., additional, Riekert, Kristin A., additional, Soffler, Morgan I., additional, Winter, Gretchen R., additional, and Sharp, Michelle, additional

Published
2021
Full Text
View/download PDF

32. A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine

Author

Sharp, Michelle, primary, Burkart, Kristin M., additional, Adelman, Mark H., additional, Ashton, Rendell W., additional, Daugherty Biddison, Lee, additional, Bosslet, Gabriel T., additional, Doyle, Stephen T., additional, Eckmann, Thomas, additional, Khurram S. Khan, Malik M., additional, Lenz, Peter H., additional, McCallister, Jennifer W., additional, O’Toole, Jacqueline, additional, Rand, Cynthia S., additional, Riekert, Kristin A., additional, Soffler, Morgan I., additional, Winter, Gretchen R., additional, Zaeh, Sandra, additional, Eakin, Michelle N., additional, Arabelovic, Senada, additional, Baer, Alan, additional, Greene, Jerome L., additional, Baker, Matthew C., additional, Bloch, Donald, additional, Cohen, Philip, additional, Danielides, Stamatina J., additional, Danila, Maria, additional, Dellaripa, Paul F., additional, Lawrence Ford, Theresa, additional, Fox, Robert I., additional, Grader-Beck, Thomas, additional, Johr, Chadwick R., additional, Kassan, Stuart, additional, Katsumoto, Tamiko, additional, Kontzias, Apostolos, additional, Koons, Kirsten, additional, Kyttaris, Vasileios C., additional, Lewis, Janet, additional, Lieberman, Scott M., additional, McCoy, Sara S., additional, Niewold, Timothy, additional, Noaiseh, Ghaith, additional, Osborn, Thomas G., additional, Culpepper Pace, Schartess, additional, Peredo-Wende, Ruben, additional, Pillemer, Stanley, additional, Neal Roberts, W., additional, Rosenstein, Elliot, additional, Sachdev, Amit, additional, Sandorfi, Nora, additional, Segal, Barbara, additional, Siva, Chokkalingam, additional, Small, Daniel, additional, Spiera, Robert F., additional, Topilow, James, additional, Treadwell, Edward L., additional, Vivino, Frederick B., additional, Volkmann, Elizabeth, additional, Wallace, Daniel J., additional, Zashin, Scott, additional, Gupta Argula, Rahul, additional, Barney, Joseph, additional, Burger, Charles D., additional, Downey, Gregory P., additional, Gagermeier, James, additional, Helmers, Richard A., additional, Hewlett, Justin C., additional, Keith, Rebecca C., additional, Koslow, Matthew, additional, Kotloff, Robert, additional, Krishna, Rachana, additional, Luckhardt, Tracy R., additional, Robinson, Keith, additional, Ryu, Jay H., additional, Shifren, Adrian, additional, Staton, Gerald, additional, Swigris, Jeff, additional, Vassallo, Robert, additional, Veraldi, Kristen L., additional, Ward, Robert W., additional, Bromet, Evelyn J., additional, Dale, Jeanne, additional, Furlong, Judith A., additional, Neall, Kerry L., additional, Petruzzi, Lynn M., additional, Schafer, Sarah, additional, and Kukla, Heidi, additional

Published
2021
Full Text
View/download PDF

35. Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

Author

Wilk, Jemma B., Shrine, Nick R. G., Loehr, Laura R., Zhao, Jing Hua, Manichaikul, Ani, Lopez, Lorna M., Smith, Albert Vernon, Heckbert, Susan R., Smolonska, Joanna, Tang, Wenbo, Loth, Daan W., Curjuric, Ivan, Hui, Jennie, Cho, Michael H., Latourelle, Jeanne C., Henry, Amanda P., Aldrich, Melinda, Bakke, Per, Beaty, Terri H., Bentley, Amy R., Borecki, Ingrid B., Brusselle, Guy G., Burkart, Kristin M., Chen, Ting-hsu, Couper, David, Crapo, James D., Davies, Gail, Dupuis, Josée, Franceschini, Nora, Gulsvik, Amund, Hancock, Dana B., Harris, Tamara B., Hofman, Albert, Imboden, Medea, James, Alan L., Khaw, Kay-Tee, Lahousse, Lies, Launer, Lenore J., Litonjua, Augusto, Liu, Yongmei, Lohman, Kurt K., Lomas, David A., Lumley, Thomas, Marciante, Kristin D., McArdle, Wendy L., Meibohm, Bernd, Morrison, Alanna C., Musk, Arthur W., Myers, Richard H., North, Kari E., Postma, Dirkje S., Psaty, Bruce M., Rich, Stephen S., Rivadeneira, Fernando, Rochat, Thierry, Rotter, Jerome I., Artigas, María Soler, Starr, John M., Uitterlinden, André G., Wareham, Nicholas J., Wijmenga, Cisca, Zanen, Pieter, Province, Michael A., Silverman, Edwin K., Deary, Ian J., Palmer, Lyle J., Cassano, Patricia A., Gudnason, Vilmundur, Barr, Graham R., Loos, Ruth J. F., Strachan, David P., London, Stephanie J., Boezen, Marike H., Probst-Hensch, Nicole, Gharib, Sina A., Hall, Ian P., O’Connor, George T., Tobin, Martin D., and Stricker, Bruno H.

Published
2012
Full Text
View/download PDF

41. A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos

Author

Burkart, Kristin M., Sofer, Tamar, London, Stephanie J., Manichaikul, Ani, Hartwig, Fernando P., Yan, Qi, Avila, Lydiana, Chen, Wei, Thomas, Sonia Davis, Diaz, Alejandro A., Hall, Ian P., Horta, Bernardo L., Kaplan, Robert C., Laurie, Cathy C., Menezes, Ana M., Morrison, Jean V., Oelsner, Elizabeth C., Rastogi, Deepa, Rich, Stephen S., Soto-Quiros, Manuel, Stilp, Adrienne M., Tobin, Martin D., Wain, Louise V., Celedon, Juan C., and Barr, R. Graham

Subjects
Hispanic/Latino, genome-wide association, single nucleotide polymorphisms, lung function, chronic obstructive pulmonary disease, respiratory tract diseases
Abstract

Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry.Objectives: Perform a GWAS of COPD-phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. Methods: GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies.Measurements and Main Results: Among 11,822 Hispanic/Latino participants, we identified eight novel signals; three replicated in independent populations of European Ancestry. A novel locus for forced expiratory volume in one second (FEV1) in ZSWIM7 (rs4791658; p=4.99×10-9) replicated. A rare variant (MAF=0.002) in HAL (rs145174011) was associated with FEV1 to forced vital capacity (FEV1/FVC) (p=9.59×10-9) in a region previously identified for COPD-related phenotypes; it remained significant in conditional analyses but did not replicate. Admixture mapping identified a novel region, with a variant in AGMO (rs41331850), associated with Amerindian ancestry and FEV1, which replicated. A novel locus for FEV1 identified among ever smokers (rs291231; p=1.92×10-8) approached statistical significance for replication in admixed populations of African ancestry and a novel SNP for COPD in PDZD2 (rs7709630; p=1.56×10-8) regionally replicated. Additionally, loci previously identified for lung function in European samples were associated in Hispanic/Latino participants in HCHS/SOL at the genome-wide significance level.Conclusions: We identified novel signals for lung function and COPD in a Hispanic/Latino cohort. Including admixed populations when performing genetic studies may identify variants contributing togenetic etiologies of COPD.

Published
2018

42. Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Author

Jackson, Victoria E, Latourelle, Jeanne C, Wain, Louise V, Smith, Albert V, Grove, Megan L, Bartz, Traci M, Obeidat, Ma'en, Province, Michael A, Gao, Wei, Qaiser, Beenish, Porteous, David J, Cassano, Patricia A, Ahluwalia, Tarunveer S, Grarup, Niels, Li, Jin, Altmaier, Elisabeth, Marten, Jonathan, Harris, Sarah E, Manichaikul, Ani, Pottinger, Tess D, Li-Gao, Ruifang, Lind-Thomsen, Allan, Mahajan, Anubha, Lahousse, Lies, Imboden, Medea, Teumer, Alexander, Prins, Bram, Lyytikäinen, Leo-Pekka, Eiriksdottir, Gudny, Franceschini, Nora, Sitlani, Colleen M, Brody, Jennifer A, Bossé, Yohan, Timens, Wim, Kraja, Aldi, Loukola, Anu, Tang, Wenbo, Liu, Yongmei, Bork-Jensen, Jette, Justesen, Johanne M, Linneberg, Allan, Lange, Leslie A, Rawal, Rajesh, Karrasch, Stefan, Huffman, Jennifer E, Smith, Blair H, Davies, Gail, Burkart, Kristin M, Mychaleckyj, Josyf C, Bonten, Tobias N, Enroth, Stefan, Lind, Lars, Brusselle, Guy G, Kumar, Ashish, Stubbe, Beate, Kähönen, Mika, Wyss, Annah B, Psaty, Bruce M, Heckbert, Susan R, Hao, Ke, Rantanen, Taina, Kritchevsky, Stephen B, Lohman, Kurt, Skaaby, Tea, Pisinger, Charlotta, Hansen, Torben, Schulz, Holger, Polasek, Ozren, Campbell, Archie, Starr, John M, Rich, Stephen S, Mook-Kanamori, Dennis O, Johansson, Åsa, Ingelsson, Erik, Uitterlinden, André G, Weiss, Stefan, Raitakari, Olli T, Gudnason, Vilmundur, North, Kari E, Gharib, Sina A, Sin, Don D, Taylor, Kent D, O'Connor, George T, Kaprio, Jaakko, Harris, Tamara B, Pederson, Oluf, Vestergaard, Henrik, Wilson, James G, Strauch, Konstantin, Hayward, Caroline, Kerr, Shona, Deary, Ian J, Barr, R Graham, de Mutsert, Renée, Gyllensten, Ulf, Morris, Andrew P, Ikram, M Arfan, Probst-Hensch, Nicole, Gläser, Sven, Zeggini, Eleftheria, Lehtimäki, Terho, Strachan, David P, Dupuis, Josée, Morrison, Alanna C, Hall, Ian P, Tobin, Martin D, London, Stephanie J, Jackson, Victoria E, Latourelle, Jeanne C, Wain, Louise V, Smith, Albert V, Grove, Megan L, Bartz, Traci M, Obeidat, Ma'en, Province, Michael A, Gao, Wei, Qaiser, Beenish, Porteous, David J, Cassano, Patricia A, Ahluwalia, Tarunveer S, Grarup, Niels, Li, Jin, Altmaier, Elisabeth, Marten, Jonathan, Harris, Sarah E, Manichaikul, Ani, Pottinger, Tess D, Li-Gao, Ruifang, Lind-Thomsen, Allan, Mahajan, Anubha, Lahousse, Lies, Imboden, Medea, Teumer, Alexander, Prins, Bram, Lyytikäinen, Leo-Pekka, Eiriksdottir, Gudny, Franceschini, Nora, Sitlani, Colleen M, Brody, Jennifer A, Bossé, Yohan, Timens, Wim, Kraja, Aldi, Loukola, Anu, Tang, Wenbo, Liu, Yongmei, Bork-Jensen, Jette, Justesen, Johanne M, Linneberg, Allan, Lange, Leslie A, Rawal, Rajesh, Karrasch, Stefan, Huffman, Jennifer E, Smith, Blair H, Davies, Gail, Burkart, Kristin M, Mychaleckyj, Josyf C, Bonten, Tobias N, Enroth, Stefan, Lind, Lars, Brusselle, Guy G, Kumar, Ashish, Stubbe, Beate, Kähönen, Mika, Wyss, Annah B, Psaty, Bruce M, Heckbert, Susan R, Hao, Ke, Rantanen, Taina, Kritchevsky, Stephen B, Lohman, Kurt, Skaaby, Tea, Pisinger, Charlotta, Hansen, Torben, Schulz, Holger, Polasek, Ozren, Campbell, Archie, Starr, John M, Rich, Stephen S, Mook-Kanamori, Dennis O, Johansson, Åsa, Ingelsson, Erik, Uitterlinden, André G, Weiss, Stefan, Raitakari, Olli T, Gudnason, Vilmundur, North, Kari E, Gharib, Sina A, Sin, Don D, Taylor, Kent D, O'Connor, George T, Kaprio, Jaakko, Harris, Tamara B, Pederson, Oluf, Vestergaard, Henrik, Wilson, James G, Strauch, Konstantin, Hayward, Caroline, Kerr, Shona, Deary, Ian J, Barr, R Graham, de Mutsert, Renée, Gyllensten, Ulf, Morris, Andrew P, Ikram, M Arfan, Probst-Hensch, Nicole, Gläser, Sven, Zeggini, Eleftheria, Lehtimäki, Terho, Strachan, David P, Dupuis, Josée, Morrison, Alanna C, Hall, Ian P, Tobin, Martin D, and London, Stephanie J

Abstract

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P<2·8x10 -7) associations with six SNPs: a nonsynonymous variant in RPAP1, which is predicted to be damaging, three intronic SNPs ( SEC24C, CASC17 and UQCC1) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU. Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.

Published
2018
Full Text
View/download PDF

43. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C, Cookson, William O. C. M., Altmüller, Janine, Ang, Wei, Barr, R Graham, Beaty, Terri H, Becker, Allan B, Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I, Bouzigon, Emmanuelle, Brightling, Christopher E, Brossard, Myriam, Brusselle, Guy G, Burchard, Esteban G., Burkart, Kristin M, Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Da Silva Couto Alves, Alexessander, Curtin, John A, Custovic, Adnan, Daley, Denise, de Jongste, Johan C, Del-Rio-Navarro, Blanca E, Donohue, Kathleen M, Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G, Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A, Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A, Gilliland, Frank, Granell, Raquel, Graves, Penelope E, Heederik, Dick, Wouters, Inge M, Australian Asthma Genetics Consortium (AAGC) collaborators, One Health Chemisch, One Health Microbieel, dIRAS RA-I&I RA, dIRAS RA-2, Dep IRAS, Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C, Cookson, William O. C. M., Altmüller, Janine, Ang, Wei, Barr, R Graham, Beaty, Terri H, Becker, Allan B, Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I, Bouzigon, Emmanuelle, Brightling, Christopher E, Brossard, Myriam, Brusselle, Guy G, Burchard, Esteban G., Burkart, Kristin M, Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Da Silva Couto Alves, Alexessander, Curtin, John A, Custovic, Adnan, Daley, Denise, de Jongste, Johan C, Del-Rio-Navarro, Blanca E, Donohue, Kathleen M, Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G, Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A, Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A, Gilliland, Frank, Granell, Raquel, Graves, Penelope E, Heederik, Dick, Wouters, Inge M, and Australian Asthma Genetics Consortium (AAGC) collaborators

Published
2018

44. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Author

Wyss, Annah B., Sofer, Tamar, Lee, Mi Kyeong, Terzikhan, Natalie, Nguyen, Jennifer N., Lahousse, Lies, Latourelle, Jeanne C., Smith, Albert Vernon, Bartz, Traci M., Feitosa, Mary F., Gao, Wei, Ahluwalia, Tarunveer S., Tang, Wenbo, Oldmeadow, Christopher, Duan, Qing, de Jong, Kim, Wojczynski, Mary K., Wang, Xin-Qun, Noordam, Raymond, Hartwig, Fernando Pires, Jackson, Victoria E., Wang, Tianyuan, Obeidat, Ma'en, Hobbs, Brian D., Huan, Tianxiao, Gui, Hongsheng, Parker, Margaret M., Hu, Donglei, Mogil, Lauren S., Kichaev, Gleb, Jin, Jianping, Graff, Mariaelisa, Harris, Tamara B., Kalhan, Ravi, Heckbert, Susan R., Paternoster, Lavinia, Burkart, Kristin M., Liu, Yongmei, Holliday, Elizabeth G., Wilson, James G., Vonk, Judith M., Sanders, Jason L., Barr, R. Graham, de Mutsert, Renee, Baptista Menezes, Ana Maria, Adams, Hieab H. H., van den Berge, Maarten, Joehanes, Roby, Levin, Albert M., Liberto, Jennifer, Launer, Lenore J., Morrison, Alanna C., Sitlani, Colleen M., Celedon, Juan C., Kritchevsky, Stephen B., Scott, Rodney J., Christensen, Kaare, Rotter, Jerome I., Bonten, Tobias N., Wehrmeister, Fernando Cesar, Bosse, Yohan, Xiao, Shujie, Oh, Sam, Franceschini, Nora, Brody, Jennifer A., Kaplan, Robert C., Lohman, Kurt, McEvoy, Mark, Province, Michael A., Rosendaal, Frits R., Taylor, Kent D., Nickle, David C., Williams, L. Keoki, Burchard, Esteban G., Wheeler, Heather E., Sin, Don D., Gudnason, Vilmundur, North, Kari E., Fornage, Myriam, Psaty, Bruce M., Myers, Richard H., O'Connor, George, Hansen, Torben, Laurie, Cathy C., Cassano, Patricia A., Sung, Joohon, Kim, Woo Jin, Attia, John R., Lange, Leslie, Boezen, H. Marike, Thyagarajan, Bharat, Rich, Stephen S., Mook-Kanamori, Dennis O., Horta, Bernardo Lessa, Uitterlinden, Andre G., Im, Hae Kyung, Cho, Michael H., Brusselle, Guy G., Gharib, Sina A., Dupuis, Josee, Manichaikul, Ani, London, Stephanie J., Wyss, Annah B., Sofer, Tamar, Lee, Mi Kyeong, Terzikhan, Natalie, Nguyen, Jennifer N., Lahousse, Lies, Latourelle, Jeanne C., Smith, Albert Vernon, Bartz, Traci M., Feitosa, Mary F., Gao, Wei, Ahluwalia, Tarunveer S., Tang, Wenbo, Oldmeadow, Christopher, Duan, Qing, de Jong, Kim, Wojczynski, Mary K., Wang, Xin-Qun, Noordam, Raymond, Hartwig, Fernando Pires, Jackson, Victoria E., Wang, Tianyuan, Obeidat, Ma'en, Hobbs, Brian D., Huan, Tianxiao, Gui, Hongsheng, Parker, Margaret M., Hu, Donglei, Mogil, Lauren S., Kichaev, Gleb, Jin, Jianping, Graff, Mariaelisa, Harris, Tamara B., Kalhan, Ravi, Heckbert, Susan R., Paternoster, Lavinia, Burkart, Kristin M., Liu, Yongmei, Holliday, Elizabeth G., Wilson, James G., Vonk, Judith M., Sanders, Jason L., Barr, R. Graham, de Mutsert, Renee, Baptista Menezes, Ana Maria, Adams, Hieab H. H., van den Berge, Maarten, Joehanes, Roby, Levin, Albert M., Liberto, Jennifer, Launer, Lenore J., Morrison, Alanna C., Sitlani, Colleen M., Celedon, Juan C., Kritchevsky, Stephen B., Scott, Rodney J., Christensen, Kaare, Rotter, Jerome I., Bonten, Tobias N., Wehrmeister, Fernando Cesar, Bosse, Yohan, Xiao, Shujie, Oh, Sam, Franceschini, Nora, Brody, Jennifer A., Kaplan, Robert C., Lohman, Kurt, McEvoy, Mark, Province, Michael A., Rosendaal, Frits R., Taylor, Kent D., Nickle, David C., Williams, L. Keoki, Burchard, Esteban G., Wheeler, Heather E., Sin, Don D., Gudnason, Vilmundur, North, Kari E., Fornage, Myriam, Psaty, Bruce M., Myers, Richard H., O'Connor, George, Hansen, Torben, Laurie, Cathy C., Cassano, Patricia A., Sung, Joohon, Kim, Woo Jin, Attia, John R., Lange, Leslie, Boezen, H. Marike, Thyagarajan, Bharat, Rich, Stephen S., Mook-Kanamori, Dennis O., Horta, Bernardo Lessa, Uitterlinden, Andre G., Im, Hae Kyung, Cho, Michael H., Brusselle, Guy G., Gharib, Sina A., Dupuis, Josee, Manichaikul, Ani, and London, Stephanie J.

Published
2018

45. Response

Author

Ashton, Rendell W., primary, Burkart, Kristin M., additional, Lenz, Peter H., additional, Kumar, Sunita, additional, and McCallister, Jennifer W., additional

Published
2018
Full Text
View/download PDF

46. Multiethnic meta-analysis identifies new loci for pulmonary function

Author

Wyss, Annah B., primary, Sofer, Tamar, additional, Lee, Mi Kyeong, additional, Terzikhan, Natalie, additional, Nguyen, Jennifer N., additional, Lahousse, Lies, additional, Latourelle, Jeanne C., additional, Smith, Albert Vernon, additional, Bartz, Traci M., additional, Feitosa, Mary F., additional, Gao, Wei, additional, Ahluwalia, Tarunveer S., additional, Tang, Wenbo, additional, Oldmeadow, Christopher, additional, Duan, Qing, additional, Jong, Kim de, additional, Wojczynski, Mary K., additional, Wang, Xin-Qun, additional, Noordam, Raymond, additional, Hartwig, Fernando Pires, additional, Jackson, Victoria E., additional, Wang, Tianyuan, additional, Obeidat, Ma’en, additional, Hobbs, Brian D., additional, Huan, Tianxiao, additional, Kichaev, Gleb, additional, Jin, Jianping, additional, Graff, Mariaelisa, additional, Harris, Tamara B., additional, Kalhan, Ravi, additional, Heckbert, Susan R., additional, Paternoster, Lavinia, additional, Burkart, Kristin M., additional, Liu, Yongmei, additional, Holliday, Elizabeth G., additional, Wilson, James G., additional, Vonk, Judith M., additional, Sanders, Jason, additional, Barr, R. Graham, additional, Mutsert, Renée de, additional, Menezes, Ana Maria Baptista, additional, Adams, Hieab H. H., additional, Berge, Maarten van den, additional, Joehanes, Roby, additional, Launer, Lenore J., additional, Morrison, Alanna C., additional, Sitlani, Colleen M., additional, Celedón, Juan C., additional, Kritchevsky, Stephen B., additional, Scott, Rodney J., additional, Christensen, Kaare, additional, Rotter, Jerome I., additional, Bonten, Tobias N., additional, César Wehrmeister, Fernando, additional, Bossé, Yohan, additional, Franceschini, Nora, additional, Brody, Jennifer A., additional, Kaplan, Robert C., additional, Lohman, Kurt, additional, McEvoy, Mark, additional, Province, Michael A., additional, Rosendaal, Frits R., additional, Taylor, Kent D., additional, Nickle, David C., additional, North, Kari E., additional, Fornage, Myriam, additional, Psaty, Bruce M., additional, Myers, Richard H., additional, O’Connor, George, additional, Hansen, Torben, additional, Laurie, Cathy C., additional, Cassano, Pat, additional, Sung, Joohon, additional, Kim, Woo Jin, additional, Attia, John R., additional, Lange, Leslie, additional, Boezen, H. Marike, additional, Thyagarajan, Bharat, additional, Rich, Stephen S., additional, Mook-Kanamori, Dennis O., additional, Horta, Bernardo Lessa, additional, Uitterlinden, André G, additional, Sin, Don D., additional, Im, Hae Kyung, additional, Cho, Michael H., additional, Brusselle, Guy G., additional, Gharib, Sina A., additional, Dupuis, Josée, additional, Manichaikul, Ani, additional, and London, Stephanie J., additional

Published
2017
Full Text
View/download PDF

47. Meta-analysis of exome array data identifies six novel genetic loci for lung function

Author

Jackson, Victoria E, primary, Latourelle, Jeanne C, additional, Wain, Louise V, additional, Smith, Albert V., additional, Grove, Megan L., additional, Bartz, Traci M, additional, Obeidat, Maen, additional, Province, Michael A, additional, Gao, Wei, additional, Qaiser, Beenish, additional, Porteous, David J, additional, Cassano, Patricia A, additional, Ahluwalia, Tarunveer S., additional, Grarup, Niels, additional, Li, Jin, additional, Altmaier, Elisabeth, additional, Marten, Jonathan, additional, Harris, Sarah E, additional, Manichaikul, Ani, additional, Pottinger, Tess D, additional, Li-Gao, Ruifang, additional, Lind-Thomsen, Allan, additional, Mahajan, Anubha, additional, Lahousse, Lies, additional, Imboden, Medea, additional, Teumer, Alexander, additional, Prins, Bram, additional, Lyytikäinen, Leo-Pekka, additional, Eiriksdottir, Gudny, additional, Franceschini, Nora, additional, Sitlani, Colleen M, additional, Brody, Jennifer A, additional, Bossé, Yohan, additional, Timens, Wim, additional, Kraja, Aldi, additional, Loukola, Anu, additional, Tang, Wenbo, additional, Liu, Yongmei, additional, Bork-Jensen, Jette, additional, Justesen, Johanne M., additional, Linneberg, Allan, additional, Lange, Leslie A., additional, Rawal, Rajesh, additional, Karrasch, Stefan, additional, Huffman, Jennifer E, additional, Smith, Blair H, additional, Davies, Gail, additional, Burkart, Kristin M, additional, Mychaleckyj, Josyf C, additional, Bonten, Tobias N., additional, Enroth, Stefan, additional, Lind, Lars, additional, Brusselle, Guy G, additional, Kumar, Ashish, additional, Stubbe, Beate, additional, Kähönen, Mika, additional, Wyss, Annah B., additional, Psaty, Bruce M, additional, Heckbert, Susan R, additional, Hao, Ke, additional, Rantanen, Taina, additional, Kritchevsky, Stephen B, additional, Lohman, Kurt, additional, Skaaby, Tea, additional, Pisinger, Charlotta, additional, Hansen, Torben, additional, Schulz, Holger, additional, Polasek, Ozren, additional, Campbell, Archie, additional, Starr, John M, additional, Rich, Stephen S, additional, Mook-Kanamori, Dennis O., additional, Johansson, Åsa, additional, Ingelsson, Erik, additional, Uitterlinden, André G, additional, Weiss, Stefan, additional, Raitakari, Olli T., additional, Gudnason, Vilmundur, additional, North, Kari E., additional, Gharib, Sina A, additional, Sin, Don D, additional, Taylor, Kent D, additional, O’Connor, George T, additional, Kaprio, Jaakko, additional, Harris, Tamara B, additional, Pedersen, Oluf, additional, Vestergaard, Henrik, additional, Wilson, James G., additional, Strauch, Konstantin, additional, Hayward, Caroline, additional, Kerr, Shona, additional, Deary, Ian J, additional, Barr, R Graham, additional, de Mutsert, Renée, additional, Gyllensten, Ulf, additional, Morris, Andrew P, additional, Ikram, M. Arfan, additional, Probst-Hensch, Nicole M, additional, Gläser, Sven, additional, Zeggini, Eleftheria, additional, Lehtimäki, Terho, additional, Strachan, David P, additional, Dupuis, Josee, additional, Morrison, Alanna C., additional, Hall, Ian P, additional, Tobin, Martin D, additional, and London, Stephanie J, additional

Published
2017
Full Text
View/download PDF

48. Interventional Pulmonology Fellowship Accreditation Standards

Author

Mullon, John J., primary, Burkart, Kristin M., additional, Silvestri, Gerard, additional, Hogarth, D. Kyle, additional, Almeida, Francisco, additional, Berkowitz, David, additional, Eapen, George A., additional, Feller-Kopman, David, additional, Fessler, Henry E., additional, Folch, Erik, additional, Gillespie, Colin, additional, Haas, Andrew, additional, Islam, Shaheen U., additional, Lamb, Carla, additional, Levine, Stephanie M., additional, Majid, Adnan, additional, Maldonado, Fabien, additional, Musani, Ali I., additional, Piquette, Craig, additional, Ray, Cynthia, additional, Reddy, Chakravarthy B., additional, Rickman, Otis, additional, Simoff, Michael, additional, Wahidi, Momen M., additional, and Lee, Hans, additional

Published
2017
Full Text
View/download PDF

50. Preparing for Fellowship in Internal Medicine, with a Focus on Pulmonary and/or Critical Care Medicine – Major Principles and New Realities

Author

Miles, Matthew C., Lenz, Peter, McCallister, Jennifer, Burkart, Kristin M., Huebert, Candace, Moore, Jason, Hinkle, Laura, Short, Briana, Bagley, Brent, and Bosslet, Gabriel

Abstract

In this manuscript, the authors provide guidance for applicants to any subspecialty in the medical specialties matching program with a particular focus on those seeking a match into a Pulmonary and/or Critical Care Medicine training program. The PAIR-Match steps (preparation, application, interview, ranking, match) are used to discuss available literature that informs this process. Preparing a fellowship application is discussed in terms of personal career goals, and specific strategies are suggested that can help a candidate assess a program’s fit with those goals. In addition to review of recent data on virtual interviewing and interview questioning, the authors provide practical recommendations for candidates seeking to maximize their success in the current interview environment. Finally, key points about generating a rank order list are summarized. This resource will prove useful to any candidate pursuing medical subspecialty training in the current era

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results