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Keywords: chronic lymphocytic leukemia; clonal haematopoiesis; composite lymphoma; mantle cell lymphoma EN chronic lymphocytic leukemia clonal haematopoiesis composite lymphoma mantle cell lymphoma 660 664 5 02/21/23 20230301 NES 230301 Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia in the Western world, accounting for 25% of adult leukaemias. To further determine which lymphoma population displaying these cytogenetic changes, we sort-purified CLL cells and MCL cells from peripheral blood by flow cytometry (Figure 2A) and performed FISH using relevant probes. Previous studies have demonstrated that CLL and MCL in composite lymphoma cases are clonally unrelated.[[3]] For example, in the largest CLL/MCL case series, using micro-dissected tissues, Hoeller et al.[3] reported that all their seven cases of composite CLL/MCL lymphomas lacked a clonal relatedness. In addition to our findings, somatic mutations that are frequently observed in clonal haematopoiesis have also been detected in CLL and angioimmunoblastic T-cell lymphoma.[[12], [15]] However, it is unclear how these pro-myeloid mutations contribute to lymphomagenesis and at which developmental stage the mutated precursor cells transform to lymphoma initiating cells. [Extracted from the article]