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819 results on '"Burke, Kathleen A."'

1. Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment.

Author

Nuttall, Barrett, Acar, Melih, Burke, Kathleen, White, Rafael, Udriste, Maria, Sharma, Shringi, Dougherty, Brian, Stetson, Daniel, Jenkins, David, Mortlock, Andrew, Forcina, Alessandra, Munugalavadla, Veerendra, Flinn, Ian, Roschewski, Mark, Patel, Manish, Reagan, Patrick, Saba, Nakhle, Collins, Graham, Arkenau, Hendrik-Tobias, and De Vos, Sven

Subjects
Humans, Circulating Tumor DNA, Neoplasm Recurrence, Local, Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse, Antineoplastic Combined Chemotherapy Protocols, Biomarkers
Abstract

PURPOSE: Novel targeted and immunotherapies have improved outcomes in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), but toxicities limit widespread use. The selective Bruton tyrosine kinase (BTK) inhibitor acalabrutinib has activity in patients with R/R DLBCL but durable responses are uncommon. STAT3 inhibition has demonstrated clinical activity in DLBCL. PATIENTS AND METHODS: Final results of the phase I study of acalabrutinib plus STAT3 inhibitor (danvatirsen; AZD9150) in patients with R/R DLBCL are reported. Danvatirsen 200 mg intravenous infusion [Days 1, 3, 5 (Cycle 1); weekly infusions starting Day 8, Cycle 1] was administered in combination with oral acalabrutinib 100 mg twice daily until progressive disease (PD) or unacceptable toxicity. Primary endpoints were safety and tolerability. Secondary endpoints included efficacy, pharmacokinetics, and immunogenicity. RESULTS: Seventeen patients received combination treatment. One dose-limiting toxicity (Grade 3 liver transaminase) occurred in 1 patient. The most common reason for treatment discontinuation was PD (65%). In evaluable patients (n = 17), objective response rate was 24%; median duration of response was 1.9 months. All responders with available DLBCL cell-of-origin data were either activated B-cell or nongerminal center B-cell like subtype. Genetic subtype did not correlate with response. Baseline and longitudinal plasma cell-free DNA (cfDNA) concentrations were mostly higher in nonresponding patients. cfDNA changes were generally concordant with imaging. Pretreatment circulating B-cell levels were higher in responders versus nonresponders. CONCLUSIONS: Targeting both STAT3 and BTK in combination is safe and tolerable but efficacy is limited in R/R DLBCL. Results support evaluation of circulating tumor DNA as a biomarker for clinical response.

Published
2023

7. Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Author

Yoshizawa, Takuya, Ali, Rustam, Jiou, Jenny, Fung, Ho Yee Joyce, Burke, Kathleen A, Kim, Seung Joong, Lin, Yuan, Peeples, William B, Saltzberg, Daniel, Soniat, Michael, Baumhardt, Jordan M, Oldenbourg, Rudolf, Sali, Andrej, Fawzi, Nicolas L, Rosen, Michael K, and Chook, Yuh Min

Subjects
Biochemistry and Cell Biology, Biological Sciences, Active Transport, Cell Nucleus, Binding Sites, Frontotemporal Lobar Degeneration, Humans, Karyopherins, Light, Liquid-Liquid Extraction, Macromolecular Substances, Magnetic Resonance Spectroscopy, Mutation, Nephelometry and Turbidimetry, Nuclear Localization Signals, Protein Binding, Protein Domains, RNA, RNA-Binding Protein FUS, Scattering, Radiation, Temperature, beta Karyopherins, FUS, PY-NLS, RNA granule, amyotrophic lateral sclerosis, biomolecular condensate, intrinsically disordered protein, karyopherin-β2, liquid-liquid phase separation, low-complexity sequences, transportin-1, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolution are poorly understood. The RNA-binding protein fused in sarcoma (FUS) undergoes LLPS in vitro and associates with condensates in cells. We show that the importin karyopherin-β2/transportin-1 inhibits LLPS of FUS. This activity depends on tight binding of karyopherin-β2 to the C-terminal proline-tyrosine nuclear localization signal (PY-NLS) of FUS. Nuclear magnetic resonance (NMR) analyses reveal weak interactions of karyopherin-β2 with sequence elements and structural domains distributed throughout the entirety of FUS. Biochemical analyses demonstrate that most of these same regions also contribute to LLPS of FUS. The data lead to a model where high-affinity binding of karyopherin-β2 to the FUS PY-NLS tethers the proteins together, allowing multiple, distributed weak intermolecular contacts to disrupt FUS self-association, blocking LLPS. Karyopherin-β2 may act analogously to control condensates in diverse cellular contexts.

Published
2018

9. 620 Multimodal real world data reveals immunogenomic drivers of acquired and primary resistance to immune checkpoint blockade

Author

Keddar, Mohamed Reda, primary, Pro, Sebastian Carrasco, additional, Burke, Kathleen, additional, Rabbie, Roy, additional, Stewart, Ana, additional, Cobbold, Mark, additional, Stewart, Ross, additional, Sidders, Benjamin, additional, Khosla, Sajan, additional, Hammond, Scott, additional, Palmer, Douglas C, additional, Dry, Jonathan R, additional, and Miller, Martin L, additional

Published
2023
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11. Supplementary Data 1 from Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment

Author

Roschewski, Mark, primary, Patel, Manish R., primary, Reagan, Patrick M., primary, Saba, Nakhle S., primary, Collins, Graham P., primary, Arkenau, Hendrik-Tobias, primary, de Vos, Sven, primary, Nuttall, Barrett, primary, Acar, Melih, primary, Burke, Kathleen, primary, White, Rafael D., primary, Udriste, Maria, primary, Sharma, Shringi, primary, Dougherty, Brian, primary, Stetson, Daniel, primary, Jenkins, David, primary, Mortlock, Andrew, primary, Forcina, Alessandra, primary, Munugalavadla, Veerendra, primary, and Flinn, Ian, primary

Published
2023
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12. Data from Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment

Author

Roschewski, Mark, primary, Patel, Manish R., primary, Reagan, Patrick M., primary, Saba, Nakhle S., primary, Collins, Graham P., primary, Arkenau, Hendrik-Tobias, primary, de Vos, Sven, primary, Nuttall, Barrett, primary, Acar, Melih, primary, Burke, Kathleen, primary, White, Rafael D., primary, Udriste, Maria, primary, Sharma, Shringi, primary, Dougherty, Brian, primary, Stetson, Daniel, primary, Jenkins, David, primary, Mortlock, Andrew, primary, Forcina, Alessandra, primary, Munugalavadla, Veerendra, primary, and Flinn, Ian, primary

Published
2023
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14. Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment

Author

Roschewski, Mark, primary, Patel, Manish R., additional, Reagan, Patrick M., additional, Saba, Nakhle S., additional, Collins, Graham P., additional, Arkenau, Hendrik-Tobias, additional, de Vos, Sven, additional, Nuttall, Barrett, additional, Acar, Melih, additional, Burke, Kathleen, additional, White, Rafael D., additional, Udriste, Maria, additional, Sharma, Shringi, additional, Dougherty, Brian, additional, Stetson, Daniel, additional, Jenkins, David, additional, Mortlock, Andrew, additional, Forcina, Alessandra, additional, Munugalavadla, Veerendra, additional, and Flinn, Ian, additional

Published
2023
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22. Supplementary Tables from HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

Author

Xu, Xiaowei, primary, De Angelis, Carmine, primary, Burke, Kathleen A., primary, Nardone, Agostina, primary, Hu, Huizhong, primary, Qin, Lanfang, primary, Veeraraghavan, Jamunarani, primary, Sethunath, Vidyalakshmi, primary, Heiser, Laura M., primary, Wang, Nicholas, primary, Ng, Charlotte K.Y., primary, Chen, Edward S., primary, Renwick, Alexander, primary, Wang, Tao, primary, Nanda, Sarmistha, primary, Shea, Martin, primary, Mitchell, Tamika, primary, Rajendran, Mahitha, primary, Waters, Ian, primary, Zabransky, Daniel J., primary, Scott, Kenneth L., primary, Gutierrez, Carolina, primary, Nagi, Chandandeep, primary, Geyer, Felipe C., primary, Chamness, Gary C., primary, Park, Ben H., primary, Shaw, Chad A., primary, Hilsenbeck, Susan G., primary, Rimawi, Mothaffar F., primary, Gray, Joe W., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, Osborne, C. Kent, primary, and Schiff, Rachel, primary

Published
2023
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24. Supplementary information from HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

Author

Xu, Xiaowei, primary, De Angelis, Carmine, primary, Burke, Kathleen A., primary, Nardone, Agostina, primary, Hu, Huizhong, primary, Qin, Lanfang, primary, Veeraraghavan, Jamunarani, primary, Sethunath, Vidyalakshmi, primary, Heiser, Laura M., primary, Wang, Nicholas, primary, Ng, Charlotte K.Y., primary, Chen, Edward S., primary, Renwick, Alexander, primary, Wang, Tao, primary, Nanda, Sarmistha, primary, Shea, Martin, primary, Mitchell, Tamika, primary, Rajendran, Mahitha, primary, Waters, Ian, primary, Zabransky, Daniel J., primary, Scott, Kenneth L., primary, Gutierrez, Carolina, primary, Nagi, Chandandeep, primary, Geyer, Felipe C., primary, Chamness, Gary C., primary, Park, Ben H., primary, Shaw, Chad A., primary, Hilsenbeck, Susan G., primary, Rimawi, Mothaffar F., primary, Gray, Joe W., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, Osborne, C. Kent, primary, and Schiff, Rachel, primary

Published
2023
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25. Figure S3 from AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Author

Balachander, Srividya B., primary, Criscione, Steven W., primary, Byth, Kate F., primary, Cidado, Justin, primary, Adam, Ammar, primary, Lewis, Paula, primary, Macintyre, Terry, primary, Wen, Shenghua, primary, Lawson, Deborah, primary, Burke, Kathleen, primary, Lubinski, Tristan, primary, Tyner, Jeffrey W., primary, Kurtz, Stephen E., primary, McWeeney, Shannon K., primary, Varnes, Jeffrey, primary, Diebold, R. Bruce, primary, Gero, Thomas, primary, Ioannidis, Stephanos, primary, Hennessy, Edward J., primary, McCoull, William, primary, Saeh, Jamal C., primary, Tabatabai, Areya, primary, Tavana, Omid, primary, Su, Nancy, primary, Schuller, Alwin, primary, Garnett, Mathew J., primary, Jaaks, Patricia, primary, Coker, Elizabeth A., primary, Gregory, Gareth P., primary, Newbold, Andrea, primary, Johnstone, Ricky W., primary, Gangl, Eric, primary, Wild, Martin, primary, Zinda, Michael, primary, Secrist, J. Paul, primary, Davies, Barry R., primary, Fawell, Stephen E., primary, and Gibbons, Francis D., primary

Published
2023
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28. Supplementary Methods from The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas

Author

Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, Geyer, Felipe C., primary, Burke, Kathleen A., primary, Pareja, Fresia, primary, Eberle, Carey A., primary, Lim, Raymond S., primary, Natrajan, Rachael, primary, Riaz, Nadeem, primary, Mariani, Odette, primary, Norton, Larry, primary, Vincent-Salomon, Anne, primary, Wen, Y. Hannah, primary, Weigelt, Britta, primary, and Reis-Filho, Jorge S., primary

Published
2023
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29. Supplementary Table S6 from The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas

Author

Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, Geyer, Felipe C., primary, Burke, Kathleen A., primary, Pareja, Fresia, primary, Eberle, Carey A., primary, Lim, Raymond S., primary, Natrajan, Rachael, primary, Riaz, Nadeem, primary, Mariani, Odette, primary, Norton, Larry, primary, Vincent-Salomon, Anne, primary, Wen, Y. Hannah, primary, Weigelt, Britta, primary, and Reis-Filho, Jorge S., primary

Published
2023
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30. Supplementary Figures and Tables from IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Author

Chiang, Sarah, primary, Weigelt, Britta, primary, Wen, Huei-Chi, primary, Pareja, Fresia, primary, Raghavendra, Ashwini, primary, Martelotto, Luciano G., primary, Burke, Kathleen A., primary, Basili, Thais, primary, Li, Anqi, primary, Geyer, Felipe C., primary, Piscuoglio, Salvatore, primary, Ng, Charlotte K.Y., primary, Jungbluth, Achim A., primary, Balss, Jörg, primary, Pusch, Stefan, primary, Baker, Gabrielle M., primary, Cole, Kimberly S., primary, von Deimling, Andreas, primary, Batten, Julie M., primary, Marotti, Jonathan D., primary, Soh, Hwei-Choo, primary, McCalip, Benjamin L., primary, Serrano, Jonathan, primary, Lim, Raymond S., primary, Siziopikou, Kalliopi P., primary, Lu, Song, primary, Liu, Xiaolong, primary, Hammour, Tarek, primary, Brogi, Edi, primary, Snuderl, Matija, primary, Iafrate, A. John, primary, Reis-Filho, Jorge S., primary, and Schnitt, Stuart J., primary

Published
2023
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31. Supplementary Figure S4 from The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas

Author

Ng, Charlotte K.Y., primary, Piscuoglio, Salvatore, primary, Geyer, Felipe C., primary, Burke, Kathleen A., primary, Pareja, Fresia, primary, Eberle, Carey A., primary, Lim, Raymond S., primary, Natrajan, Rachael, primary, Riaz, Nadeem, primary, Mariani, Odette, primary, Norton, Larry, primary, Vincent-Salomon, Anne, primary, Wen, Y. Hannah, primary, Weigelt, Britta, primary, and Reis-Filho, Jorge S., primary

Published
2023
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32. Data from IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Author

Chiang, Sarah, primary, Weigelt, Britta, primary, Wen, Huei-Chi, primary, Pareja, Fresia, primary, Raghavendra, Ashwini, primary, Martelotto, Luciano G., primary, Burke, Kathleen A., primary, Basili, Thais, primary, Li, Anqi, primary, Geyer, Felipe C., primary, Piscuoglio, Salvatore, primary, Ng, Charlotte K.Y., primary, Jungbluth, Achim A., primary, Balss, Jörg, primary, Pusch, Stefan, primary, Baker, Gabrielle M., primary, Cole, Kimberly S., primary, von Deimling, Andreas, primary, Batten, Julie M., primary, Marotti, Jonathan D., primary, Soh, Hwei-Choo, primary, McCalip, Benjamin L., primary, Serrano, Jonathan, primary, Lim, Raymond S., primary, Siziopikou, Kalliopi P., primary, Lu, Song, primary, Liu, Xiaolong, primary, Hammour, Tarek, primary, Brogi, Edi, primary, Snuderl, Matija, primary, Iafrate, A. John, primary, Reis-Filho, Jorge S., primary, and Schnitt, Stuart J., primary

Published
2023
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33. Supplementary Figure Legends from IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Author

Chiang, Sarah, primary, Weigelt, Britta, primary, Wen, Huei-Chi, primary, Pareja, Fresia, primary, Raghavendra, Ashwini, primary, Martelotto, Luciano G., primary, Burke, Kathleen A., primary, Basili, Thais, primary, Li, Anqi, primary, Geyer, Felipe C., primary, Piscuoglio, Salvatore, primary, Ng, Charlotte K.Y., primary, Jungbluth, Achim A., primary, Balss, Jörg, primary, Pusch, Stefan, primary, Baker, Gabrielle M., primary, Cole, Kimberly S., primary, von Deimling, Andreas, primary, Batten, Julie M., primary, Marotti, Jonathan D., primary, Soh, Hwei-Choo, primary, McCalip, Benjamin L., primary, Serrano, Jonathan, primary, Lim, Raymond S., primary, Siziopikou, Kalliopi P., primary, Lu, Song, primary, Liu, Xiaolong, primary, Hammour, Tarek, primary, Brogi, Edi, primary, Snuderl, Matija, primary, Iafrate, A. John, primary, Reis-Filho, Jorge S., primary, and Schnitt, Stuart J., primary

Published
2023
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34. Supplementary Materials and Methods from IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Author

Chiang, Sarah, primary, Weigelt, Britta, primary, Wen, Huei-Chi, primary, Pareja, Fresia, primary, Raghavendra, Ashwini, primary, Martelotto, Luciano G., primary, Burke, Kathleen A., primary, Basili, Thais, primary, Li, Anqi, primary, Geyer, Felipe C., primary, Piscuoglio, Salvatore, primary, Ng, Charlotte K.Y., primary, Jungbluth, Achim A., primary, Balss, Jörg, primary, Pusch, Stefan, primary, Baker, Gabrielle M., primary, Cole, Kimberly S., primary, von Deimling, Andreas, primary, Batten, Julie M., primary, Marotti, Jonathan D., primary, Soh, Hwei-Choo, primary, McCalip, Benjamin L., primary, Serrano, Jonathan, primary, Lim, Raymond S., primary, Siziopikou, Kalliopi P., primary, Lu, Song, primary, Liu, Xiaolong, primary, Hammour, Tarek, primary, Brogi, Edi, primary, Snuderl, Matija, primary, Iafrate, A. John, primary, Reis-Filho, Jorge S., primary, and Schnitt, Stuart J., primary

Published
2023
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35. Supplementary Figures from HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

Author

Xu, Xiaowei, primary, De Angelis, Carmine, primary, Burke, Kathleen A., primary, Nardone, Agostina, primary, Hu, Huizhong, primary, Qin, Lanfang, primary, Veeraraghavan, Jamunarani, primary, Sethunath, Vidyalakshmi, primary, Heiser, Laura M., primary, Wang, Nicholas, primary, Ng, Charlotte K.Y., primary, Chen, Edward S., primary, Renwick, Alexander, primary, Wang, Tao, primary, Nanda, Sarmistha, primary, Shea, Martin, primary, Mitchell, Tamika, primary, Rajendran, Mahitha, primary, Waters, Ian, primary, Zabransky, Daniel J., primary, Scott, Kenneth L., primary, Gutierrez, Carolina, primary, Nagi, Chandandeep, primary, Geyer, Felipe C., primary, Chamness, Gary C., primary, Park, Ben H., primary, Shaw, Chad A., primary, Hilsenbeck, Susan G., primary, Rimawi, Mothaffar F., primary, Gray, Joe W., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, Osborne, C. Kent, primary, and Schiff, Rachel, primary

Published
2023
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38. Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

Author

Geyer, Felipe C, Berman, Samuel H, Marchiò, Caterina, Burke, Kathleen A, Guerini-Rocco, Elena, Piscuoglio, Salvatore, Ng, Charlotte KY, Pareja, Fresia, Wen, Hannah Y, Hodi, Zoltan, Schnitt, Stuart J, Rakha, Emad A, Ellis, Ian O, Norton, Larry, Weigelt, Britta, and Reis-Filho, Jorge S

Published
2017
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48. Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer

Author

Fusco, Nicola, Geyer, Felipe C, De Filippo, Maria R, Martelotto, Luciano G, Ng, Charlotte K Y, Piscuoglio, Salvatore, Guerini-Rocco, Elena, Schultheis, Anne M, Fuhrmann, Laetitia, Wang, Lu, Jungbluth, Achim A, Burke, Kathleen A, Lim, Raymond S, Vincent-Salomon, Anne, Bamba, Masamichi, Moritani, Suzuko, Badve, Sunil S, Ichihara, Shu, Ellis, Ian O, Reis-Filho, Jorge S, and Weigelt, Britta

Published
2016
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49. Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer

Author

Rimawi, Mothaffar F., De Angelis, Carmine, Contreras, Alejandro, Pareja, Fresia, Geyer, Felipe C., Burke, Kathleen A., Herrera, Sabrina, Wang, Tao, Mayer, Ingrid A., Forero, Andres, Nanda, Rita, Goetz, Matthew P., Chang, Jenny C., Krop, Ian E., Wolff, Antonio C., Pavlick, Anne C., Fuqua, Suzanne A. W., Gutierrez, Carolina, Hilsenbeck, Susan G., Li, Marilyn M., Weigelt, Britta, Reis-Filho, Jorge S., Kent Osborne, C., and Schiff, Rachel

Published
2017
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